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TDMS Study 05033-01 Pathology Tables

NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97
Route: DOSED FEED                                                                                                 Time: 14:51:15




       Facility:  TSI Mason Research

       Chemical CAS #:  117-39-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 1| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 2| 1| 6| 9| 3| 2| 9| 1| 7| 3| 2| 3| 2| 4| 2| 8| 0| 6| 6| 2| 3| 8| 3| 6|             
                                           | 1| 4| 8| 4| 1| 2| 5| 1| 3| 2| 1| 9| 1| 4| 1| 3| 7| 6| 6| 6| 9| 2| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Parasite Metazoan                    |                1                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Parasite Metazoan                    |                   1           X  1                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +  +     +  +  +  M  +  +  +  +  +  +        +  M  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 1  2  1        2  2     1     1  2     1  1  1  1  2        1  1  1  1   |             
      Clear Cell Focus                     |                                                                          |             
      Developmental Malformation           |                         2                                   2            |             
      Eosinophilic Focus                   |                                                    2                     |             
      Fatty Change                         |       2                    3        4     3                          2   |             
      Inflammation, Chronic, Granulomatous |                   1     1                 2     1                        |             
      Inflammation, Chronic                |    1                                                                     |             
      Inflammation, Chronic Active         |                                                             1            |             
      Mixed Cell Focus                     |                                                 3                        |             
      Necrosis, Coagulative                |    1                                                                     |             
      Pigmentation                         |                                     1                                    |             
      Bile Duct, Hyperplasia               | 1              1        1        1  2                       1  1  1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic, Granulomatous |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Atrophy                              | 1  1  1           1                 1  1           1        1     1      |             
      Inflammation, Chronic                | 1  1  1        1  1                                1        1            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                         +                 +        +                 +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Acanthosis                           |                                                                          |             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |                1                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Inflammation, Chronic Active         |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 1| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 2| 1| 6| 9| 3| 2| 9| 1| 7| 3| 2| 3| 2| 4| 2| 8| 0| 6| 6| 2| 3| 8| 3| 6|             
                                           | 1| 4| 8| 4| 1| 2| 5| 1| 3| 2| 1| 9| 1| 4| 1| 3| 7| 6| 6| 6| 9| 2| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                           4                              |             
      Mucosa, Dilatation                   |                         1                                                |             
      Muscularis, Developmental            |                                                                          |             
          Malformation                     |    2                                                                     |             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  | +  +                    +     +  +  +        +  +  +           +         |             
      Inflammation, Chronic                |    1                                            1                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Cardiomyopathy                       | 2  1  2        2  2     1  1  1  2     1     2  1  1        2  1  2  1   |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active, Necrotizing      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Angiectasis                          |    1  2        1  2     1     1  1     1        1  2        1        1   |             
      Congestion                           |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia                          |       1                          1           2     1           1         |             
      Necrosis, Coagulative                |                            3                                             |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |    1  1        1        1     2                 1           1  1  1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Angiectasis                          |    1           1  2                                                  1   |             
      Hyperplasia                          |                                                             1            |             
      Necrosis, Coagulative                |                            3                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Ectopic Tissue                       |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +  +     +  +  +  +  +  +  +  M  +  +        M  M  +  M   |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Pars Distalis, Angiectasis           |    2                             2           2                           |             
      Pars Distalis, Cyst                  | 2  2                    1  1        2  2           1        3  2         |             
      Pars Distalis, Hemorrhage            |                   2                                                      |             
      Pars Distalis, Hyperplasia           | 1                 2                    1           1           1         |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Angiectasis         |                                           2                              |             
      Pars Nervosa, Angiectasis            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  | 1  1           1  1     1  1  1     1  1  1  1  1  1        1  2  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 1| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 2| 1| 6| 9| 3| 2| 9| 1| 7| 3| 2| 3| 2| 4| 2| 8| 0| 6| 6| 2| 3| 8| 3| 6|             
                                           | 1| 4| 8| 4| 1| 2| 5| 1| 3| 2| 1| 9| 1| 4| 1| 3| 7| 6| 6| 6| 9| 2| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicle, Cyst                       |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                   +              +  +     +        +                 +   |             
      Abscess                              |                                                                          |             
      Cyst                                 |                   3                                                      |             
      Hyperplasia                          |                   2                                                      |             
      Inflammation, Chronic                |                                           1        1                 1   |             
      Inflammation, Chronic Active         |                                     4                                    |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Cyst                                 | 4                                      3                                 |             
      Periovarian Tissue, Cyst             |                               2     2                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Hydrometra                           |    1                                                           2     1   |             
      Endometrium, Hyperplasia             | 2                                   1                                    |             
      Lumen, Exudate                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                         +                 +        +                 +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |             
          Cell                             |                                                                          |             
      Mediastinal, Hemorrhage              |                                              1              1            |             
      Mediastinal, Pigmentation            |                                                             1            |             
      Pancreatic, Hemorrhage               |                            3                                             |             
      Renal, Hemorrhage                    |                                                 1                        |             
      Renal, Infiltration Cellular         |                                                 2                        |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Renal, Pigmentation                  |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  M   |             
      Ectasia                              |    2                    1     2                                2         |             
      Hemorrhage                           |    4  2        3  1              3     3                       1         |             
      Hyperplasia, Plasma Cell             | 2                                   2                                    |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                         +                 +        +                 +   |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                         1                 1        1                 2   |             
      Pigmentation                         |                         1                 1        1                 1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Depletion Lymphoid                   |                                     3     2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 1| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 2| 1| 6| 9| 3| 2| 9| 1| 7| 3| 2| 3| 2| 4| 2| 8| 0| 6| 6| 2| 3| 8| 3| 6|             
                                           | 1| 4| 8| 4| 1| 2| 5| 1| 3| 2| 1| 9| 1| 4| 1| 3| 7| 6| 6| 6| 9| 2| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                2                                                         |             
      Thrombosis                           |                                                                          |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +                    +                 +        +                 M   |             
      Depletion Lymphoid                   |                                           3        2                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +        +        +  +        +  +  +  +  +  +        +  +  +  +   |             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |                         2           2  2  2        2                 2   |             
                                            __________________________________________________________________________|             
   Skin                                    |       +                 +                 +  +     +                 +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                         +                 +        +                 +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Hydrocephalus                        |       2                                         2                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Crystals                             |                                           3                              |             
      Hemorrhage                           |                                           2                       1      |             
      Infiltration Cellular, Histiocyte    | 1  1           1        1     1        1  3  1     1                 1   |             
      Inflammation, Chronic                |                   1                                                      |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Mineralization               |    1  1        1                 1  1              1                     |             
                                            __________________________________________________________________________|             
   Nose                                    |                         +                 +                          +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                   +                             +   |             
      Cataract                             |    3                                   4                                 |             
      Synechia                             |                                                                          |             
      Retina, Degeneration                 |    4                                   3                                 |             
      Sclera, Mineralization               |    2                                                                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  A  +   |             
      Nephropathy                          | 3  1  3        3  1     1  2  2  2  1  3  1  3  2  1        2  3     2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 1| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 2| 1| 6| 9| 3| 2| 9| 1| 7| 3| 2| 3| 2| 4| 2| 8| 0| 6| 6| 2| 3| 8| 3| 6|             
                                           | 1| 4| 8| 4| 1| 2| 5| 1| 3| 2| 1| 9| 1| 4| 1| 3| 7| 6| 6| 6| 9| 2| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Collecting Tubule, Mineralization    |                                                                          |             
      Renal Tubule, Hyperplasia            | 1                                                                        |             
      Transitional Epithelium, Hyperplasia | 2                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +     +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Subserosa, Mineralization            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 4| 1| 7| 7| 6| 1| 4| 7| 6| 1| 4| 4| 7| 7| 6| 7| 1| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 3| 9| 6| 9| 3| 3| 7| 9| 6| 2| 2| 9| 6| 2| 3| 2| 6| 2| 9| 2| 3| 2| 2| 6|             
                                           | 8| 2| 1| 4| 1| 1| 2| 2| 1| 4| 4| 5| 3| 6| 2| 1| 9| 0| 4| 3| 9| 2| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Parasite Metazoan                    |                1                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Parasite Metazoan                    | 2                 1                                   1           1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Parasite Metazoan                    |                                                 1                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +           +  +  +        +  +        M  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    2           2  2  1        2  1              1  2  1     1  2  1  1   |             
      Clear Cell Focus                     |                                  2           3              3            |             
      Developmental Malformation           |                X                                                         |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                      4           1        3        1                     |             
      Inflammation, Chronic, Granulomatous |                               1                       1              1   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mixed Cell Focus                     |                1                                                         |             
      Necrosis, Coagulative                |                               1                                          |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Hyperplasia               | 3  1           1  1                          1                       1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +  +                           |             
      Inflammation, Chronic, Granulomatous |                                              3                           |             
      Necrosis, Coagulative                |                                           4  1                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Atrophy                              |                   1           1           1     3  2              2      |             
      Inflammation, Chronic                |                   1           1                 1  1              1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                  +        M                              |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +              +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Acanthosis                           |                      1                                                   |             
      Edema                                |                                                                          |             
      Erosion                              |                      1                                                   |             
      Hyperkeratosis                       |                      1                                                   |             
      Hyperplasia, Basal Cell              |    1                 1                                                   |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic Active         |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 4| 1| 7| 7| 6| 1| 4| 7| 6| 1| 4| 4| 7| 7| 6| 7| 1| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 3| 9| 6| 9| 3| 3| 7| 9| 6| 2| 2| 9| 6| 2| 3| 2| 6| 2| 9| 2| 3| 2| 2| 6|             
                                           | 8| 2| 1| 4| 1| 1| 2| 2| 1| 4| 4| 5| 3| 6| 2| 1| 9| 0| 4| 3| 9| 2| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Dilatation                   |    2                                               1              1      |             
      Muscularis, Developmental            |                                                                          |             
          Malformation                     |                                                                          |             
      Muscularis, Mineralization           |                2                                                         |             
                                            __________________________________________________________________________|             
   Tongue                                  | +  +           +                          M  +  +     +     +  +  +      |             
      Inflammation, Chronic                |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Cardiomyopathy                       | 2  2           2  2  3        2  1           2  2  2  2     2  1  1  2   |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active, Necrotizing      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Angiectasis                          |                1  2              2           3     2  1     1            |             
      Congestion                           |                                                                          |             
      Degeneration, Fatty                  |                                           3                              |             
      Hyperplasia                          |    1              1                             1     1        2     2   |             
      Necrosis, Coagulative                |                                                                          |             
      Thrombosis                           |                                              3                           |             
      Vacuolization Cytoplasmic            | 1  1           2                          3  2        1     1  2  1  1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +           +  +  +        +  +           +  +  +  +     +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                              1                           |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Ectopic Tissue                       |                X                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M           +  +  +        M  M        +  +  +  +  +     +  +  +  I   |             
      Cyst                                 |                                              1                           |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Pars Distalis, Angiectasis           |    2           3  2           2                       1                  |             
      Pars Distalis, Cyst                  | 3  2           1  2              1           3  1           2  2  2  1   |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                2                 2        1  1     2           2     2   |             
      Pars Distalis, Pigmentation          |                                           1                              |             
      Pars Intermedia, Angiectasis         |                                                 3                        |             
      Pars Nervosa, Angiectasis            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                4  1  1                       1  1  1        2  1     1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 4| 1| 7| 7| 6| 1| 4| 7| 6| 1| 4| 4| 7| 7| 6| 7| 1| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 3| 9| 6| 9| 3| 3| 7| 9| 6| 2| 2| 9| 6| 2| 3| 2| 6| 2| 9| 2| 3| 2| 2| 6|             
                                           | 8| 2| 1| 4| 1| 1| 2| 2| 1| 4| 4| 5| 3| 6| 2| 1| 9| 0| 4| 3| 9| 2| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicle, Cyst                       |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +                             M           +           +                  |             
      Abscess                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                           1                              |             
      Inflammation, Chronic Active         | 3                                                     3                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Periovarian Tissue, Cyst             | 1                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Hydrometra                           |    3                 1                             1           1         |             
      Endometrium, Hyperplasia             |                               1              1                           |             
      Lumen, Exudate                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                  +        +                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +  M  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |             
          Cell                             |                                                                          |             
      Mediastinal, Hemorrhage              |                                  1                 1                     |             
      Mediastinal, Pigmentation            |                                  1                                       |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Infiltration Cellular         |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +           +  M  +        +  +        M  +  +  +  +     +  +  +  +   |             
      Ectasia                              | 2                                               2  1                     |             
      Hemorrhage                           |    2           3     1        3              1        2     1  1  1  3   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                  +        +                              |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                  1                                       |             
      Pigmentation                         |                                  1                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Depletion Lymphoid                   |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 4| 1| 7| 7| 6| 1| 4| 7| 6| 1| 4| 4| 7| 7| 6| 7| 1| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 3| 9| 6| 9| 3| 3| 7| 9| 6| 2| 2| 9| 6| 2| 3| 2| 6| 2| 9| 2| 3| 2| 2| 6|             
                                           | 8| 2| 1| 4| 1| 1| 2| 2| 1| 4| 4| 5| 3| 6| 2| 1| 9| 0| 4| 3| 9| 2| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                                          |             
      Thrombosis                           |                                                                          |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                  +        +                              |             
      Depletion Lymphoid                   |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +           +     +        +  +        +     +  +        +  +         |             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |                                  2        2                              |             
                                            __________________________________________________________________________|             
   Skin                                    |                   +              +        +                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                  +        +                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Hydrocephalus                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Crystals                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                1         |             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               1                                          |             
      Artery, Mineralization               |    1           1  1  1        1              1  1  1           1  1      |             
                                            __________________________________________________________________________|             
   Nose                                    |                                  +        +                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +           +  +  +        +           +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Cataract                             |                                                                      4   |             
      Synechia                             |                                                                      4   |             
      Retina, Degeneration                 |                                                                      4   |             
      Sclera, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Nephropathy                          | 2  3           2  2  3        3  1           2  3  1  2     2  2  3  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 4| 1| 7| 7| 6| 1| 4| 7| 6| 1| 4| 4| 7| 7| 6| 7| 1| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 3| 9| 6| 9| 3| 3| 7| 9| 6| 2| 2| 9| 6| 2| 3| 2| 6| 2| 9| 2| 3| 2| 2| 6|             
                                           | 8| 2| 1| 4| 1| 1| 2| 2| 1| 4| 4| 5| 3| 6| 2| 1| 9| 0| 4| 3| 9| 2| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Collecting Tubule, Mineralization    |                      1                                                   |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +           +  +  +        +  +        +  +  +  +  +     +  +  +  +   |             
      Subserosa, Mineralization            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6|              |            |
                                           | 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Parasite Metazoan                    |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Parasite Metazoan                    |                                  1                    X                  |      9  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  48        |
      Parasite Metazoan                    |                                     1     1     1     2                  |      5  1.2|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Angiectasis                          |                                                 2                        |      1  2.0|
      Basophilic Focus                     | 1              2     1        1     1     1  1  1  2  1                  |     40  1.3|
      Clear Cell Focus                     |    1                                                                     |      4  2.3|
      Developmental Malformation           |                                                                          |      3  2.0|
      Eosinophilic Focus                   | 1                                      2                                 |      3  1.7|
      Fatty Change                         |       2           3              3        1           1                  |     14  2.4|
      Inflammation, Chronic, Granulomatous |                      1                 1  1  1        1                  |     12  1.1|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                 1                        |      2  1.0|
      Mixed Cell Focus                     |                                        3  4                              |      4  2.8|
      Necrosis, Coagulative                |       1                                         1                        |      4  1.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                1                             1     1                     |     17  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Inflammation, Chronic, Granulomatous |                                                                          |      1  3.0|
      Necrosis, Coagulative                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Atrophy                              |    1              1           1     1  1     1                           |     21  1.2|
      Inflammation, Chronic                |    1  1                       1     1  1                                 |     17  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                        +  +                              |   7        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  49        |
      Acanthosis                           |    2              2                                                      |      3  1.7|
      Edema                                |    2                                                                     |      1  2.0|
      Erosion                              |                                                                          |      1  1.0|
      Hyperkeratosis                       |    2              2                                                      |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6|              |            |
                                           | 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Basal Cell              |                   2                                                      |      4  1.3|
      Inflammation, Chronic Active         |    2              2                                                      |      3  2.0|
      Ulcer                                |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Inflammation, Chronic Active         |                   2                                                      |      3  1.3|
      Ulcer                                |                                                                          |      1  4.0|
      Mucosa, Dilatation                   |    1                             1                                       |      6  1.2|
      Muscularis, Developmental            |                                                                          |            |
          Malformation                     |                                                                          |      1  2.0|
      Muscularis, Mineralization           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  | +  +           +              +  +        +  +  +  +  +                  |  29        |
      Inflammation, Chronic                | 1              1                                1  1                     |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Cardiomyopathy                       | 2  1  1        2  2  2        1  1  2  2  1  2  2  1  2                  |     47  1.6|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active, Necrotizing      |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Angiectasis                          | 1              1     2              2     1  1  1  1  1                  |     28  1.4|
      Congestion                           |       4                                                                  |      1  4.0|
      Degeneration, Fatty                  |                                                                          |      1  3.0|
      Hyperplasia                          |                1                    1  1     2        1                  |     16  1.3|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            | 1  1  3        2  2  1           2           2  1                        |     28  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  49        |
      Angiectasis                          |    1                                                                     |      5  1.2|
      Hyperplasia                          |                                     1                                    |      3  1.0|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +                 +     +  +  +  +  +  +                  |  44        |
      Ectopic Tissue                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +  +  +        +  +  +  +  +  +  +  +  M                  |  40        |
      Cyst                                 |                                                                          |      1  1.0|
      Hyperplasia                          |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6|              |            |
                                           | 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Angiectasis           | 3     3              2        2                 2     4                  |     14  2.3|
      Pars Distalis, Cyst                  |                2     2        2           1     1     2                  |     26  1.8|
      Pars Distalis, Hemorrhage            |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           | 2     1        2     2                    1     2                        |     18  1.6|
      Pars Distalis, Pigmentation          |                                                                          |      1  1.0|
      Pars Intermedia, Angiectasis         |                      1           2           2                           |      5  2.0|
      Pars Nervosa, Angiectasis            |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Ultimobranchial Cyst                 |                      1                                                   |      1  1.0|
      C-Cell, Hyperplasia                  | 1  1  1        2  1  1              1  2  1  2  1  1  1                  |     38  1.2|
      Follicle, Cyst                       |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +           +                 +  +  +                              |  14        |
      Abscess                              |                   2                                                      |      1  2.0|
      Cyst                                 |       2           4                                                      |      3  3.0|
      Hyperplasia                          |                   3                                                      |      2  2.5|
      Inflammation, Chronic                |       1                                   1                              |      6  1.0|
      Inflammation, Chronic Active         |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Cyst                                 |                      2                                                   |      3  3.0|
      Periovarian Tissue, Cyst             |                   2                             2                        |      5  1.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Hydrometra                           |       1                          2           2  2                        |     11  1.5|
      Endometrium, Hyperplasia             |       1                          2                                       |      6  1.3|
      Lumen, Exudate                       |                                              4        4                  |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                        +  +                              |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +  +        +  +  +  +  +  +  +  M  +                  |  48        |
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |            |
          Cell                             |                                                 3                        |      1  3.0|
      Mediastinal, Hemorrhage              |       1              1                 2  1                              |      8  1.1|
      Mediastinal, Pigmentation            |                                                                          |      2  1.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  3.0|
      Renal, Hemorrhage                    | 2                                                                        |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6|              |            |
                                           | 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Infiltration Cellular         |                                                                          |      1  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       | 3                                                                        |      1  3.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +        +  +  +        +  +  +  +  +  +  +  M  +                  |  46        |
      Ectasia                              |                      3        1     1  1                                 |     11  1.6|
      Hemorrhage                           | 2     1                       1     1           4                        |     22  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.0|
      Pigmentation                         |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +                                +  +                              |   9        |
      Hemorrhage                           |       4                                                                  |      1  4.0|
      Infiltration Cellular, Histiocyte    |       2                                1  1                              |      8  1.3|
      Pigmentation                         |       1                                1  1                              |      8  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Depletion Lymphoid                   |                                        2           2                     |      5  2.6|
      Pigmentation                         |                                                                          |      1  2.0|
      Thrombosis                           |                                  3                                       |      1  3.0|
      Capsule, Hyperplasia                 |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                        +  +                              |   8        |
      Depletion Lymphoid                   |                                        2  3                              |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +              +  +  +           +     +  +     +  +  +                  |  36        |
      Hyperplasia, Cystic                  | 4                                                                        |      1  4.0|
      Hyperplasia                          | 4                 3                    3  3        3                     |     13  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                        +  +                              |  11        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                        +  +                              |   8        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Hydrocephalus                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Crystals                             |                                                                          |      1  3.0|
      Hemorrhage                           |                                  1                 1                     |      4  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6|              |            |
                                           | 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Histiocyte    | 1              1              1                                          |     14  1.1|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                                           1                              |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                              1                           |      2  1.0|
      Artery, Mineralization               | 1                 1  1        1  1  1     1     1                        |     24  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                        +  +                              |   7        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                            +                        |   6        |
      Cataract                             |    3                                            3                        |      5  3.4|
      Synechia                             |                                                                          |      1  4.0|
      Retina, Degeneration                 |    4                                            3                        |      5  3.6|
      Sclera, Mineralization               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                      +                          +                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  49        |
      Nephropathy                          | 3  4  2        4  4  1        2  1  2  2  2  2  1  3  1                  |     48  2.1|
      Collecting Tubule, Mineralization    |                                                                          |      1  1.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |    2           2  1              2              2     2                  |      7  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +  +  +        +  +  +  +  +  +  +  +  +                  |  50        |
      Subserosa, Mineralization            |                                              1                           |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 6| 7| 6| 6| 4| 5| 7| 6| 6| 6| 5| 7| 7| 4| 1| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 2| 6| 2| 8| 1| 0| 0| 0| 6| 9| 2| 8| 2| 1| 1| 2| 2| 6| 9| 6| 2| 2| 2| 4| 6|             
                                           | 9| 8| 5| 0| 3| 4| 3| 3| 4| 7| 3| 0| 6| 2| 5| 8| 5| 4| 1| 4| 9| 9| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.1% LF                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +     +  +     +        +  +  +                              |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +     +  +     +        +  +  +                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +     +  +     +        +  +  +                              |             
      Lymphoid Tissue, Hypoplasia          |                   3                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +     +  +     +        +  +  +                              |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +     +  +     +        +  +  +                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
      Autolysis                            |                                              2                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
      Angiectasis                          | 2           1                                                            |             
      Basophilic Focus                     | 2  2  2  2     2           1  2     2        1  2           2  2  2      |             
      Clear Cell Focus                     |                               1                             1            |             
      Cytoplasmic Alteration               |          2                                                               |             
      Degeneration                         |                                                                          |             
      Fatty Change                         |                   3  2           4     3  3  1                       3   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic, Granulomatous | 1        1  2     2           1        2     1              1     1      |             
      Inflammation, Chronic Active         |                      1                                                   |             
      Mixed Cell Focus                     |             3                                               2  2         |             
      Necrosis, Coagulative                |                                                 3                        |             
      Pigmentation                         |                                                                   1      |             
      Bile Duct, Hyperplasia               |             2        1     1     2  1     2                    1         |             
      Serosa, Fibrosis                     |                                                                          |             
      Serosa, Hemorrhage                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          M                    +                                          |             
      Fibrosis                             |                               3                                          |             
      Inflammation, Chronic, Granulomatous |                                                                          |             
      Inflammation, Chronic                |                               3                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                               3                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
      Atrophy                              |    1           1                 2           1                 1  1      |             
      Cytoplasmic Alteration               |                                                                   1      |             
      Inflammation, Chronic                | 1  1           1  1                 1                       1  1  1      |             
      Pigmentation                         |                1                                                         |             
      Artery, Perivascular, Inflammation,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 6| 7| 6| 6| 4| 5| 7| 6| 6| 6| 5| 7| 7| 4| 1| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 2| 6| 2| 8| 1| 0| 0| 0| 6| 9| 2| 8| 2| 1| 1| 2| 2| 6| 9| 6| 2| 2| 2| 4| 6|             
                                           | 9| 8| 5| 0| 3| 4| 3| 3| 4| 7| 3| 0| 6| 2| 5| 8| 5| 4| 1| 4| 9| 9| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.1% LF                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Chronic, Necrotizing            |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +     +  +     +        +  +  +                              |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
      Acanthosis                           |                   2              1                                   2   |             
      Edema                                |                                        4                                 |             
      Hyperkeratosis                       |                   2                                                  2   |             
      Hyperplasia, Basal Cell              |                                  2                                   2   |             
      Inflammation, Acute                  |                                                                      4   |             
      Inflammation, Chronic Active         |                   4              2     3                                 |             
      Necrosis, Coagulative                |                   2                                                      |             
      Ulcer                                |                                        4                                 |             
      Artery, Muscularis, Mineralization   |                                                 1                        |             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
      Edema                                |                                        4                                 |             
      Inflammation, Chronic Active         |                                        3                                 |             
      Artery, Mineralization               | 1                                               1                        |             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  | +  +  +  +     M  +  +     +  +  +        +  +  +           +  +  +  +   |             
      Hemorrhage                           |                                                 1                        |             
      Inflammation, Chronic                |                            1                                             |             
      Arteriole, Necrosis, Fibrinoid       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +     +  +     +        +  +  +                              |             
      Cardiomyopathy                       |             1     1  1     2        2  2                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +        +     +  +     +        +  +  +                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +     +  +     +        +  +  +                              |             
      Angiectasis                          |             2        1                                                   |             
      Atrophy                              |                                                                          |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |                   2        1           1  2                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +     +  +     +        +  +  +                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +           +     +  +     +        +  +  +                              |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +     +  +  M  +  +  +  M  +           +  M  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
      Pars Distalis, Angiectasis           |                3                 4              2              2         |             
      Pars Distalis, Cyst                  |       3                    1     4        2  1                 1  1      |             
      Pars Distalis, Hyperplasia           |          1                 2  1  1              2              2  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 6| 7| 6| 6| 4| 5| 7| 6| 6| 6| 5| 7| 7| 4| 1| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 2| 6| 2| 8| 1| 0| 0| 0| 6| 9| 2| 8| 2| 1| 1| 2| 2| 6| 9| 6| 2| 2| 2| 4| 6|             
                                           | 9| 8| 5| 0| 3| 4| 3| 3| 4| 7| 3| 0| 6| 2| 5| 8| 5| 4| 1| 4| 9| 9| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.1% LF                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Angiectasis         |          4     3                                                     1   |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Nervosa, Angiectasis            |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +           +  +  +  +   |             
      C-Cell, Hyperplasia                  | 1  1  2  2  2  2  1  1     1  1     1  2  1     1           1  1  1  1   |             
      Follicular Cell, Hyperplasia         |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |             +     +  +     +           +  +                 +            |             
      Abscess                              |                                                             4            |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |             1     2  1     2           2  1                              |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +     +  +     +        +  +  +                              |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
      Hydrometra                           | 1                             3           2     1              2         |             
      Inflammation, Chronic                |                               1                             1            |             
      Pigmentation                         |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Cervix, Inflammation, Chronic        |                                                                          |             
      Endometrium, Hyperplasia             |                                                                2  1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +     +  +     +        +  +  +                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +  +  +     +     +  +  +  +                              |             
      Mediastinal, Hemorrhage              |          3                                                               |             
      Mediastinal, Pigmentation            |          2                                                               |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                  2                                       |             
      Renal, Pigmentation                  |                                  1                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +  +  +  +     +        +  +  +                              |             
      Congestion                           |                                                                          |             
      Ectasia                              |                1                       3                                 |             
      Hemorrhage                           |                3                       2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 6| 7| 6| 6| 4| 5| 7| 6| 6| 6| 5| 7| 7| 4| 1| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 2| 6| 2| 8| 1| 0| 0| 0| 6| 9| 2| 8| 2| 1| 1| 2| 2| 6| 9| 6| 2| 2| 2| 4| 6|             
                                           | 9| 8| 5| 0| 3| 4| 3| 3| 4| 7| 3| 0| 6| 2| 5| 8| 5| 4| 1| 4| 9| 9| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.1% LF                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +     +  +     +     +  +  +  +                              |             
      Infiltration Cellular, Histiocyte    |             2     2  1     2     2  1  1  1                              |             
      Pigmentation                         |             1     1  1     1     2  1  1  1                              |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +  +  +     +     +  +  +  +  +                    +      |             
      Depletion Lymphoid                   |             1  1  2  1                    3                              |             
      Fibrosis                             |          3                                                               |             
      Hematopoietic Cell Proliferation     |                   3                                                      |             
      Inflammation, Chronic, Granulomatous |          4                                                               |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             M     +  +     +     +  +  M  +                              |             
      Depletion Lymphoid                   |                   3  1     2     3        2                              |             
      Hemorrhage                           |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +  +     +  +     +        +  +  +  +              +  +         |             
      Galactocele                          |    4                                                                     |             
      Hyperplasia                          |    2        2     2  2     2        3  3  4                 3            |             
                                            __________________________________________________________________________|             
   Skin                                    |                +  +  +     +     +  +  +  +     +                        |             
      Inflammation, Chronic                |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +        +     +  +     +        +  +  +                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +     +  +     +     +  +  +  +                              |             
      Hydrocephalus                        |                                                                          |             
      Meninges, Hemorrhage                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +  +  +  +  +     +        +  +  +                       +      |             
      Hemorrhage                           |          1                                1                              |             
      Infiltration Cellular, Histiocyte    |             1                       1  1  1                              |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Mineralization               |             1  1                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    |             +     +  +     +        +  +  +                              |             
      Congestion                           |                                                                          |             
      Lumen, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +     +  +     +        +  +  +                              |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 6| 7| 6| 6| 4| 5| 7| 6| 6| 6| 5| 7| 7| 4| 1| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 2| 6| 2| 8| 1| 0| 0| 0| 6| 9| 2| 8| 2| 1| 1| 2| 2| 6| 9| 6| 2| 2| 2| 4| 6|             
                                           | 9| 8| 5| 0| 3| 4| 3| 3| 4| 7| 3| 0| 6| 2| 5| 8| 5| 4| 1| 4| 9| 9| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.1% LF                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +     I  I                                I           +            |             
      Cataract                             |       4                                                                  |             
      Synechia                             |       4                                                     4            |             
      Cornea, Fibrosis                     |                                                             3            |             
      Retina, Degeneration                 |       3                                                     3            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                               +            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                             2            |             
      Inflammation, Chronic                |             1                                                            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          | 3  2  2  1  2  1  2  3     2  2  1  3  1  1  3  2           3  2  1  4   |             
      Artery, Fibrosis                     |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Degeneration, Hyaline           |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                                                             1        1   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                           4                              |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                   1  2        1                                      3   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +           +  +  +  +   |             
      Inflammation, Chronic                |                                        1                       1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 1| 7| 4| 7| 7| 7| 6| 4| 7| 7| 1| 6| 5| 7| 7| 7| 7| 4| 1| 7| 5| 4| 1|             
                             DAY ON TEST   | 9| 2| 9| 2| 9| 2| 2| 2| 8| 6| 3| 2| 9| 8| 4| 2| 2| 3| 2| 6| 9| 2| 4| 6| 9|             
                                           | 1| 3| 1| 5| 7| 3| 3| 9| 3| 4| 1| 4| 1| 7| 3| 3| 3| 1| 4| 6| 1| 1| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    0.1% LF                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +                             +                       +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                             +                       +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                             +                       +      |             
      Lymphoid Tissue, Hypoplasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                             +                       +      |             
      Parasite Metazoan                    |                                                                   1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +                             +                       +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +  +  +  +  +  +     +  +     +  +  +  +  +  +        +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +  +  +  +  +  +     +  +     +  +  +  +  +  +        +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +  +  +  +  +  +     +  +     +  +  +  +  +  +        +  +      |             
      Serosa, Fibrosis                     |                2                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +  +  +  +  +  +     +  +     +  M  +  +  +  +        +  +      |             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +     +  +  +  +  +  +     +  +     +  +  +  +  +  +        +  +      |             
      Angiectasis                          |                   1                             2                        |             
      Basophilic Focus                     |    3     2  1  2  2  1  2     1  2     2     1  1  2  2        2         |             
      Clear Cell Focus                     |          2                                         1                     |             
      Cytoplasmic Alteration               |    1                                                  1                  |             
      Degeneration                         |                                                                          |             
      Fatty Change                         |                                           2                       2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                   3      |             
      Hepatodiaphragmatic Nodule           |                X                                               X         |             
      Inflammation, Chronic, Granulomatous |                   2           1  2           1        1        1         |             
      Inflammation, Chronic Active         |                               1                                          |             
      Mixed Cell Focus                     |                         1                                                |             
      Necrosis, Coagulative                |                               1                                          |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Hyperplasia               |             1        1  1                          1  1                  |             
      Serosa, Fibrosis                     |                                              1                           |             
      Serosa, Hemorrhage                   |                                              1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                      +     +                  |             
      Fibrosis                             |          3                                      2     3                  |             
      Inflammation, Chronic, Granulomatous |                                                 2                        |             
      Inflammation, Chronic                |          3                                            3                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                       1                  |             
      Necrosis, Coagulative                |          3                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +  +  +  +  +  +     +  +     +  +  +  +  +  +        +  +      |             
      Atrophy                              |          1           1  1     1  1     3  1  2     1              2      |             
      Cytoplasmic Alteration               |             1                                                            |             
      Inflammation, Chronic                |                      1  1     1  1     1     1  1  1           1         |             
      Pigmentation                         |                                                                          |             
      Artery, Perivascular, Inflammation,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 1| 7| 4| 7| 7| 7| 6| 4| 7| 7| 1| 6| 5| 7| 7| 7| 7| 4| 1| 7| 5| 4| 1|             
                             DAY ON TEST   | 9| 2| 9| 2| 9| 2| 2| 2| 8| 6| 3| 2| 9| 8| 4| 2| 2| 3| 2| 6| 9| 2| 4| 6| 9|             
                                           | 1| 3| 1| 5| 7| 3| 3| 9| 3| 4| 1| 4| 1| 7| 3| 3| 3| 1| 4| 6| 1| 1| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    0.1% LF                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Chronic, Necrotizing            |                      2                                                   |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +                             +                       +      |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +  +  +  +  +  +     +  +     +  +  +  +  +  +        +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +  +  +  +  +  +     +  +     +  +  +  +  +  +        +  +      |             
      Acanthosis                           |                                                                          |             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Ulcer                                |                                                                          |             
      Artery, Muscularis, Mineralization   |                                                                          |             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +  +  +  +  +  +     +  +     +  +  +  +  +  +        +  +      |             
      Edema                                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |    +     +  +  +  +  +  M     +  +     M  +  +  +  +  +        +  +      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |    1                          1           1  1                           |             
      Arteriole, Necrosis, Fibrinoid       |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +  +                          +                       +      |             
      Cardiomyopathy                       |             2                             2                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +                             +                       +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +                             +                       +      |             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |             1                             3                       2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +                             +                       +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +                             +           +           +      |             
      Hyperplasia                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     M  +  +  +  +  M     M  +     +  M  +  +  +  +        +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +  +  +  +  +     +  +     +  +  +  +  +  +        +  +      |             
      Pars Distalis, Angiectasis           |                   2     2     3        1  2        3              4      |             
      Pars Distalis, Cyst                  |          2  2     2     2     3                 2  3           2  2      |             
      Pars Distalis, Hyperplasia           |          3  2  1  2  2  2     2  2        1  2     1           3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 1| 7| 4| 7| 7| 7| 6| 4| 7| 7| 1| 6| 5| 7| 7| 7| 7| 4| 1| 7| 5| 4| 1|             
                             DAY ON TEST   | 9| 2| 9| 2| 9| 2| 2| 2| 8| 6| 3| 2| 9| 8| 4| 2| 2| 3| 2| 6| 9| 2| 4| 6| 9|             
                                           | 1| 3| 1| 5| 7| 3| 3| 9| 3| 4| 1| 4| 1| 7| 3| 3| 3| 1| 4| 6| 1| 1| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    0.1% LF                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Pigmentation          |                1  2                                                      |             
      Pars Intermedia, Angiectasis         |                                  1     1     4                           |             
      Pars Intermedia, Cyst                |          2                                                               |             
      Pars Nervosa, Angiectasis            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +        +  +  +  +  +     +        +  +     +  +              +      |             
      C-Cell, Hyperplasia                  |    1           3  1     1     1        1        1  1              2      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |             +     +              +        +                    +  +      |             
      Abscess                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |             2                                                            |             
      Inflammation, Chronic                |                   1                                               1      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +           +                 +     +     +        +  +      |             
      Periovarian Tissue, Cyst             |                         3                       4     3                  |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +     +  +  +  +  +  +     +  +     +  +  +  +  +  +        +  +      |             
      Hydrometra                           |                      2                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation                         |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Cervix, Inflammation, Chronic        |                                                                          |             
      Endometrium, Hyperplasia             |                   1           1                 1                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                             +                       +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +        +              +  +     +  +              +      |             
      Mediastinal, Hemorrhage              |             4                             4                              |             
      Mediastinal, Pigmentation            |                                                                          |             
      Renal, Ectasia                       |                3                                2                        |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                 3                        |             
      Renal, Pigmentation                  |                2                                3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +  +           +              +  +                       +      |             
      Congestion                           |                                                                          |             
      Ectasia                              |          2              3              2                                 |             
      Hemorrhage                           |          4                             2                          1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 1| 7| 4| 7| 7| 7| 6| 4| 7| 7| 1| 6| 5| 7| 7| 7| 7| 4| 1| 7| 5| 4| 1|             
                             DAY ON TEST   | 9| 2| 9| 2| 9| 2| 2| 2| 8| 6| 3| 2| 9| 8| 4| 2| 2| 3| 2| 6| 9| 2| 4| 6| 9|             
                                           | 1| 3| 1| 5| 7| 3| 3| 9| 3| 4| 1| 4| 1| 7| 3| 3| 3| 1| 4| 6| 1| 1| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    0.1% LF                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |                                           1                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +                             +                       +      |             
      Infiltration Cellular, Histiocyte    |             1                             2                       2      |             
      Pigmentation                         |             1                             1                       2      |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +     +              +        +     +  +              +      |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Inflammation, Chronic, Granulomatous |                   3                                                      |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +                             +                       +      |             
      Depletion Lymphoid                   |                                           2                              |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +  +  +  +     +     +        +  +  +  +  +           +  +      |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |    3        2  4              3           2     4                 3      |             
                                            __________________________________________________________________________|             
   Skin                                    |             +                             +  +                    +      |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +                             +                       +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +                             +        +              +      |             
      Hydrocephalus                        |                                                                          |             
      Meninges, Hemorrhage                 |                                                    2                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                    +                     |             
      Hemorrhage                           |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +           +              +  +                       +      |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                         1                                                |             
      Alveolar Epithelium, Hyperplasia     |                         1                                                |             
      Artery, Mineralization               |             1                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                             +                       +      |             
      Congestion                           |                                                                   4      |             
      Lumen, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +                             +                       +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 1| 7| 4| 7| 7| 7| 6| 4| 7| 7| 1| 6| 5| 7| 7| 7| 7| 4| 1| 7| 5| 4| 1|             
                             DAY ON TEST   | 9| 2| 9| 2| 9| 2| 2| 2| 8| 6| 3| 2| 9| 8| 4| 2| 2| 3| 2| 6| 9| 2| 4| 6| 9|             
                                           | 1| 3| 1| 5| 7| 3| 3| 9| 3| 4| 1| 4| 1| 7| 3| 3| 3| 1| 4| 6| 1| 1| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    0.1% LF                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Eye                                     |          +           +  +                          +           I         |             
      Cataract                             |                                                    4                     |             
      Synechia                             |                                                                          |             
      Cornea, Fibrosis                     |          2                                                               |             
      Retina, Degeneration                 |          2           4                             3                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
      Hemorrhage                           |          1                                                               |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |          2                                                               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +  +  +  +  +  +     +  +     +  +  +  +  +  +        +  +      |             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                   3      |             
      Inflammation, Chronic                |    2                                                                     |             
      Nephropathy                          |    4     3  2  3  2  4  2     2  2     2  2  2  3  2  3        2  2      |             
      Artery, Fibrosis                     |                      2                                                   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Degeneration, Hyaline           |                                                                   4      |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                                  1           1                           |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                                                          |             
      Renal Tubule, Hyperplasia            |                                  1                                       |             
      Transitional Epithelium, Hyperplasia |          1           2           1                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +  +  +  +  +  +     +  +     +  +  +  +  +  +        +  +      |             
      Inflammation, Chronic                |          1                    1                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6|              |            |
                                           | 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    0.1% LF                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +                             +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +                             A                                 |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +                             A                                 |  11        |
      Lymphoid Tissue, Hypoplasia          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +                             A                                 |  11        |
      Parasite Metazoan                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +                             A                                 |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +        +     +  +     +  +  +  +  +  A     +     +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +     +  +     +  +  +  +  A  A     +     +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +        +     +  +     +  +  +  +  A  A     +     +  +                  |  48        |
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +        +     +  +     +  +  +  +  A  A     +     +  +                  |  47        |
      Autolysis                            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +     +  +     +  +  +  +  +  +     +     +  +                  |  50        |
      Angiectasis                          |                                              2                           |      5  1.6|
      Basophilic Focus                     | 1              1  1     2     2  1  2        2     2  2                  |     38  1.7|
      Clear Cell Focus                     |                                                                          |      4  1.3|
      Cytoplasmic Alteration               |                1                                                         |      4  1.3|
      Degeneration                         |                                        4                                 |      1  4.0|
      Fatty Change                         |          3                 3                          1                  |     12  2.5|
      Hematopoietic Cell Proliferation     |                                                    1                     |      1  1.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                       X                  |      3     |
      Inflammation, Chronic, Granulomatous |                1                                      1                  |     17  1.3|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Mixed Cell Focus                     |                2                    1              3                     |      7  2.0|
      Necrosis, Coagulative                |                            1                       1  1                  |      5  1.4|
      Pigmentation                         |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                                              1        1                  |     14  1.2|
      Serosa, Fibrosis                     |                                                                          |      1  1.0|
      Serosa, Hemorrhage                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                 +                                                      |   6        |
      Fibrosis                             | 3                 2                                                      |      6  2.7|
      Inflammation, Chronic, Granulomatous |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      3  3.0|
      Inflammation, Chronic Active         | 3                 3                                                      |      2  3.0|
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis, Coagulative                | 2                                                                        |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +     +  +     +  +  +  +  +  A     +     +  +                  |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6|              |            |
                                           | 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    0.1% LF                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              | 1        1              1  2        1                                    |     21  1.3|
      Cytoplasmic Alteration               |                                                                          |      2  1.0|
      Inflammation, Chronic                | 1              1  1     1     1                                          |     22  1.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Artery, Perivascular, Inflammation,  |                                                                          |            |
           Chronic, Necrotizing            |                                                                          |      1  2.0|
      Duct, Dilatation                     |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +                             +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +        +     +  +     +  +  +  +  +  +     +     +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +     +  +     +  +  +  +  +  +     +     +  +                  |  50        |
      Acanthosis                           |                                                                          |      3  1.7|
      Edema                                |                                                                          |      1  4.0|
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Hyperplasia, Basal Cell              |                                                                          |      2  2.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  4.0|
      Artery, Muscularis, Mineralization   |                                                                          |      1  1.0|
      Muscularis, Mineralization           |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +        +     +  +     +  +  +  +  +  A     +     +  +                  |  49        |
      Edema                                |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Artery, Mineralization               |                   2                                                      |      3  1.3|
      Muscularis, Mineralization           |                   2                                1                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  | +        +     +  +     +  M  +  +  +  +     +     +  +                  |  43        |
      Hemorrhage                           |                                                    2                     |      2  1.5|
      Inflammation, Chronic                |                                              1        1                  |      7  1.0|
      Arteriole, Necrosis, Fibrinoid       |                                              1                           |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +                             +                                 |  13        |
      Cardiomyopathy                       |                                        2                                 |      9  1.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +                 +           +                                 |  14        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +                 +           +                                 |  13        |
      Angiectasis                          |                                                                          |      2  1.5|
      Atrophy                              |          2                                                               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6|              |            |
                                           | 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    0.1% LF                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         |          2                                                               |      1  2.0|
      Vacuolization Cytoplasmic            |                            2                                             |      8  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +                 +           +                                 |  13        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +        +              +     A                                 |  15        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +        +     M  +     +  +  +  +  +  M     M     +  +                  |  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +     +  +     +  +  +  +  +  M     +     +  +                  |  49        |
      Pars Distalis, Angiectasis           |                                                                          |     11  2.5|
      Pars Distalis, Cyst                  | 1                       3  1        4        2                           |     21  2.1|
      Pars Distalis, Hyperplasia           | 2                       3  3  1                                          |     23  1.8|
      Pars Distalis, Pigmentation          |                1                                                         |      3  1.3|
      Pars Intermedia, Angiectasis         |                                                                          |      6  2.3|
      Pars Intermedia, Cyst                |                   1                                                      |      2  1.5|
      Pars Nervosa, Angiectasis            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +        +     +  +     +  +  +  +     +     +     +  +                  |  43        |
      C-Cell, Hyperplasia                  | 1        2     1  1     1  1  1  2                 1  1                  |     37  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          +     +  +     +     +  +     +                                 |  20        |
      Abscess                              |          3                                                               |      2  3.5|
      Cyst                                 |                2  3                                                      |      2  2.5|
      Hyperplasia                          |                               3                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                         1     1                                          |     10  1.3|
      Inflammation, Chronic Active         |                   2              2                                       |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +              +           M  +                                 |  17        |
      Periovarian Tissue, Cyst             |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +        +     +  +     +  +  +  +  +  +     +     +  +                  |  50        |
      Hydrometra                           | 1                       2                             1                  |      9  1.7|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Pigmentation                         |                         1                                                |      1  1.0|
      Cervix, Cyst                         |                               2                                          |      1  2.0|
      Cervix, Inflammation, Chronic        |                               1                                          |      1  1.0|
      Endometrium, Hyperplasia             |                            1                 1                           |      7  1.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6|              |            |
                                           | 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    0.1% LF                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +                             A                                 |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +     +  +        +        +  +                                 |  25        |
      Mediastinal, Hemorrhage              |                                                                          |      3  3.7|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
      Renal, Ectasia                       |                                                                          |      2  2.5|
      Renal, Hemorrhage                    |                   1                                                      |      1  1.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                   2                                                      |      3  2.3|
      Renal, Pigmentation                  |                   2                                                      |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +     +           +        +  +                                 |  19        |
      Congestion                           |                                     1                                    |      1  1.0|
      Ectasia                              |                                                                          |      5  2.2|
      Hemorrhage                           |                1                                                         |      6  2.2|
      Infiltration Cellular, Histiocyte    |                2                       1                                 |      2  1.5|
      Pigmentation                         |                                        1                                 |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +        +                    +                                 |  14        |
      Infiltration Cellular, Histiocyte    |          1        1                    1                                 |     14  1.4|
      Pigmentation                         |          1        1                    1                                 |     14  1.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +                 +           +                                 |  23        |
      Depletion Lymphoid                   |                                                                          |      5  1.6|
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Inflammation, Chronic, Granulomatous |                                                                          |      2  3.5|
      Thrombosis                           |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +                             M                                 |  10        |
      Depletion Lymphoid                   |          2                                                               |      7  2.1|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +        +              +     +  +  +  +     +     +  +                  |  36        |
      Galactocele                          |                                                                          |      1  4.0|
      Hyperplasia                          |          2                    4        2           3                     |     20  2.8|
                                            __________________________________________________________________________|____________|
   Skin                                    |          +                             +                                 |  15        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +                             +                                 |  13        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6|              |            |
                                           | 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    0.1% LF                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +     +                       +                                 |  15        |
      Hydrocephalus                        |          2                                                               |      1  2.0|
      Meninges, Hemorrhage                 |                2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                +                                                         |   2        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +        +        +        +  +                                 |  20        |
      Hemorrhage                           |                                        1                                 |      3  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      5  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Artery, Mineralization               |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +                             +                                 |  12        |
      Congestion                           |                                                                          |      1  4.0|
      Lumen, Inflammation, Acute           |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +                             +                                 |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     | I        +     +           I                                             |   8        |
      Cataract                             |                                                                          |      2  4.0|
      Synechia                             |                2                                                         |      3  3.3|
      Cornea, Fibrosis                     |                                                                          |      2  2.5|
      Retina, Degeneration                 |                2                                                         |      6  2.8|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   4        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |          1                                                               |      3  1.3|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +     +  +     +  +  +  +  +  A     +     +  +                  |  49        |
      Autolysis                            |                                     3                                    |      1  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Nephropathy                          | 2        2     3  3     2  2  2  1           4     3  2                  |     48  2.3|
      Artery, Fibrosis                     |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6|              |            |
                                           | 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    0.1% LF                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Degeneration, Hyaline           |                                                                          |      1  4.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Inflammation, Acute             |                                                                          |      4  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Pigmentation                    |                                                                          |      1  4.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |          2                                   1                           |      9  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +     +  +     +  +  +  +  +  +     +     +  +                  |  49        |
      Inflammation, Chronic                |                                                                          |      4  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 1| 7| 6| 4| 1| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 3| 9| 1| 0| 2| 2| 2| 6| 6| 9| 2| 6| 6| 9| 2| 2| 2| 0| 6| 2| 2| 2| 2| 6|             
                                           | 4| 1| 1| 8| 7| 9| 4| 5| 6| 4| 1| 3| 6| 4| 1| 4| 4| 9| 9| 0| 3| 4| 4| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0% MF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                      +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                      +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                      +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                      +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                      +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +  +  +           +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +           +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                       1                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +           +  +        +  +  +  M  +  +  +  +  +   |             
      Epithelium, Pigmentation             |                1     2           1              2              2  1  1   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  M           +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                       4                  |             
      Epithelium, Pigmentation             |          1                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +           +  +        +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |          2                                                               |             
      Basophilic Focus                     | 1  1        2  1  2  2           2  2                 1  1  2  2  1  2   |             
      Clear Cell Focus                     |                                                                          |             
      Cyst Multilocular                    |                                                                          |             
      Degeneration                         |                                                                          |             
      Fatty Change                         |          1  1  1                                   2                     |             
      Granuloma                            |                                                                          |             
      Hemorrhage                           |                                                                      2   |             
      Hepatodiaphragmatic Nodule           |                                                 1                        |             
      Inflammation, Acute                  |                                                                      1   |             
      Inflammation, Chronic, Granulomatous |                      1           2           1  1              1         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                      1   |             
      Mixed Cell Focus                     |                                              1                           |             
      Necrosis, Coagulative                |                                                                      1   |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Hyperplasia               |          2        1                 1                 1                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Fibrosis                             |                                              4                           |             
      Inflammation, Chronic, Granulomatous |                                                                          |             
      Mineralization                       |                                              2                           |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +           +  +        +  +  +  +  +  +  +  +  +   |             
      Atrophy                              |          1     1                                   1     1     2         |             
      Cytoplasmic Alteration               | 1  1                                                                     |             
      Inflammation, Chronic                |             1  1                                                     1   |             
      Artery, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                      +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +           +  +        +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 1| 7| 6| 4| 1| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 3| 9| 1| 0| 2| 2| 2| 6| 6| 9| 2| 6| 6| 9| 2| 2| 2| 0| 6| 2| 2| 2| 2| 6|             
                                           | 4| 1| 1| 8| 7| 9| 4| 5| 6| 4| 1| 3| 6| 4| 1| 4| 4| 9| 9| 0| 3| 4| 4| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0% MF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +           +  +        +  +  +  +  +  +  +  +  +   |             
      Acanthosis                           |          1  2                                      1                     |             
      Hyperkeratosis                       |             3                                                            |             
      Hyperplasia, Basal Cell              |          1                                         1  1                  |             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |             4                                                            |             
      Artery, Mineralization               |                                                                          |             
      Muscularis, Mineralization           |                                     1           1                        |             
      Submucosa, Mineralization            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +           +  +        +  +  +  +  +  +  +  +  +   |             
      Artery, Mineralization               |    2                                                                     |             
      Epithelium, Pigmentation             |                1                                1              1         |             
      Mucosa, Dilatation                   |          1  2                                2  2  1                     |             
      Muscularis, Mineralization           |    2                                1                 1                  |             
                                            __________________________________________________________________________|             
   Tongue                                  | +  +     +  M  +  +  +           +  +        +  +  +  M  +  +  +  +      |             
      Hemorrhage                           |                                                                   2      |             
      Inflammation, Chronic                |                1  1  1           1                          1            |             
      Arteriole, Necrosis, Fibrinoid       |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                      +   |             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +                                         +  +              +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +                                         +  +              +   |             
      Angiectasis                          |                                                                      1   |             
      Congestion                           |                                                       2                  |             
      Hyperplasia                          |                                                                      1   |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +                                         +  +              +   |             
      Angiectasis                          |          4                                                               |             
      Hyperplasia                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                     +                                +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     M  +  M  +  +           +  +        +  +  M  M  +  +  +  +  +   |             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +           +  +        +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Angiectasis           | 2        2  2                                3                           |             
      Pars Distalis, Cyst                  |    2              2              2                    2     2  2         |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Hyperplasia           | 2           2     2                          2        2        1         |             
      Pars Distalis, Infiltration Cellular,|                                                                          |             
           Histiocyte                      | 1                                                                        |             
      Pars Distalis, Pigmentation          | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 1| 7| 6| 4| 1| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 3| 9| 1| 0| 2| 2| 2| 6| 6| 9| 2| 6| 6| 9| 2| 2| 2| 0| 6| 2| 2| 2| 2| 6|             
                                           | 4| 1| 1| 8| 7| 9| 4| 5| 6| 4| 1| 3| 6| 4| 1| 4| 4| 9| 9| 0| 3| 4| 4| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0% MF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Angiectasis         |          2  1                                                            |             
      Pars Intermedia, Cyst                |                   1              X                                1      |             
      Pars Intermedia, Pigmentation        |                                                                          |             
      Pars Nervosa, Cyst                   |    1                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +           +  +        +  +  +  +  +  +  +  +  +   |             
      C-Cell, Hyperplasia                  | 1        1  1  1  1  1           1  1        2  1  2  3  1  2  1  1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +           +                                +                       +   |             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  | 3                                                                        |             
      Inflammation, Chronic                |                                                                      1   |             
      Inflammation, Chronic Active         |                                              4                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M     M  +  M  M  M           M  M        +  M  M  M  M  M  +  M  +   |             
      Congestion                           |                                                                          |             
      Periovarian Tissue, Cyst             | 3           4                                4                 4         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +           +  +        +  +  +  +  +  +  +  +  +   |             
      Cyst                                 |                   3                                   2                  |             
      Hydrometra                           |          3                                                           3   |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Hyperplasia             | 1        2           2                             1                     |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                      +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +     +                             +     +           +  +  +   |             
      Mediastinal, Hemorrhage              |                                              3                           |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                   2      |             
      Pancreatic, Pigmentation             |                                                                   2      |             
      Renal, Hemorrhage                    |                                                                   1      |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                   2      |             
      Renal, Pigmentation                  |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                              +     +           +     +   |             
      Hemorrhage                           |                                              2                 3         |             
      Infiltration Cellular, Histiocyte    |                                                                2         |             
      Necrosis, Coagulative                |                                                    1                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +     +                                   +                 +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 1| 7| 6| 4| 1| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 3| 9| 1| 0| 2| 2| 2| 6| 6| 9| 2| 6| 6| 9| 2| 2| 2| 0| 6| 2| 2| 2| 2| 6|             
                                           | 4| 1| 1| 8| 7| 9| 4| 5| 6| 4| 1| 3| 6| 4| 1| 4| 4| 9| 9| 0| 3| 4| 4| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0% MF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                          |             
      Ectasia                              |          2                                                               |             
      Hemorrhage                           |                2                                                         |             
      Infiltration Cellular, Histiocyte    |                1                                   1                 2   |             
      Pigmentation                         |                1                                                     1   |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +                          +        +     +  +  +     +     +   |             
      Depletion Lymphoid                   |                                                       3                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                3         |             
      Inflammation, Chronic, Granulomatous |                                                                3         |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                      +   |             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +        +  +     +              +                    +  +  +     +   |             
      Galactocele                          |    2                                                                     |             
      Hyperplasia                          |    3           3                                                     1   |             
                                            __________________________________________________________________________|             
   Skin                                    |                                     +                                +   |             
      Inflammation, Acute, Necrotizing     |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                     +                                +   |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +                                         +  +  +     +  +   |             
      Foreign Body                         |             1                                                            |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                          1        2      |             
      Inflammation, Chronic Active         |             2                                                            |             
      Leukocytosis                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                   2      |             
      Artery, Mineralization               |                                                             1            |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                      +   |             
      Glands, Inflammation, Acute          |                                                                      1   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 1| 7| 6| 4| 1| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 3| 9| 1| 0| 2| 2| 2| 6| 6| 9| 2| 6| 6| 9| 2| 2| 2| 0| 6| 2| 2| 2| 2| 6|             
                                           | 4| 1| 1| 8| 7| 9| 4| 5| 6| 4| 1| 3| 6| 4| 1| 4| 4| 9| 9| 0| 3| 4| 4| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0% MF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
      Cataract                             |                                  4                                       |             
      Synechia                             |                                  4                                       |             
      Retina, Degeneration                 |                                  4                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +           +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                       2                  |             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          | 2  2     2  4  3  2  1           2  2        2  2  3  3  2  3  2  2  1   |             
      Artery, Thrombosis                   |                                                                          |             
      Papilla, Necrosis, Coagulative       |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                                                          |             
      Renal Tubule, Hyperplasia, Cystic    |             3                                                            |             
      Renal Tubule, Hyperplasia            |             1     2                             2                        |             
      Transitional Epithelium, Hyperplasia |          2     2                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +           +  +        +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 1|             
                             DAY ON TEST   | 3| 2| 2| 6| 2| 2| 2| 9| 3| 2| 2| 2| 2| 6| 6| 2| 3| 2| 0| 6| 2| 2| 2| 0| 9|             
                                           | 1| 9| 4| 4| 4| 4| 4| 1| 1| 9| 4| 4| 5| 6| 6| 4| 1| 5| 3| 4| 3| 9| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0% MF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                       +              +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                  +                    +              +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                  +                    +              +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                       +              +   |             
      Parasite Metazoan                    |                                                                      1   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                       +              +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +     +  +  +  +   |             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +     +  +  +  +   |             
      Epithelium, Pigmentation             |    1  1                 1        1           2     1  1     2  1     1   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +     +  +  +  +   |             
      Autolysis                            |                                                                          |             
      Epithelium, Pigmentation             |       1                                                     1            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +     +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 2  1  1     2  1  1     1  1  1  1  2        1  2  2        2  2  1  1   |             
      Clear Cell Focus                     |       1           1                                         1            |             
      Cyst Multilocular                    |                                     3                                    |             
      Degeneration                         |                                     2                                    |             
      Fatty Change                         |             1                                         2     1            |             
      Granuloma                            |                1                                                         |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                            X                 X                 X         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic, Granulomatous | 1  1              1           1                             1            |             
      Inflammation, Chronic                |                                                                      1   |             
      Inflammation, Chronic Active         |                                                                          |             
      Mixed Cell Focus                     |                   2                 4                          2         |             
      Necrosis, Coagulative                | 1                                                                    1   |             
      Pigmentation                         |    1                                                                     |             
      Bile Duct, Hyperplasia               |       1        1                 1  1        1  1              1     1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic, Granulomatous |                                                                          |             
      Mineralization                       |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +     +  +  +  +   |             
      Atrophy                              |    2        1           1  1  1     1        1  1     2     1  1  2      |             
      Cytoplasmic Alteration               | 1  2                                                                     |             
      Inflammation, Chronic                |    1  1     1  1        1     1  1  1        1  1  1  1     1  1  1      |             
      Artery, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                       +              +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 1|             
                             DAY ON TEST   | 3| 2| 2| 6| 2| 2| 2| 9| 3| 2| 2| 2| 2| 6| 6| 2| 3| 2| 0| 6| 2| 2| 2| 0| 9|             
                                           | 1| 9| 4| 4| 4| 4| 4| 1| 1| 9| 4| 4| 5| 6| 6| 4| 1| 5| 3| 4| 3| 9| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0% MF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +     +  +  +  +   |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Muscularis, Mineralization           |                                                                          |             
      Submucosa, Mineralization            | 1                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +     +  +  +  +   |             
      Artery, Mineralization               |                                                                          |             
      Epithelium, Pigmentation             |    1        2                                               2     2      |             
      Mucosa, Dilatation                   |                                                                          |             
      Muscularis, Mineralization           | 3                                                              2         |             
                                            __________________________________________________________________________|             
   Tongue                                  | +  +  +     +  +  +     +  +  +  +  +        +  +  M  +     +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                | 1              1        1                    1              1            |             
      Arteriole, Necrosis, Fibrinoid       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                       +              +   |             
      Cardiomyopathy                       |                                                       1              1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +                 +                                M  +              +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +                 +                                   +              +   |             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Hyperplasia                          | 1                                                                        |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +                 +                                   +              +   |             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                       +              +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +     M  M  +  M  +        M  +  +  +     +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +     +  +  +  +   |             
      Pars Distalis, Angiectasis           |             3           3        1              2              2         |             
      Pars Distalis, Cyst                  |       1        2  4        2  1     1              2        1  2         |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Hyperplasia           |       1           2           3  3  2        2  2  1        2            |             
      Pars Distalis, Infiltration Cellular,|                                                                          |             
           Histiocyte                      |                                                                          |             
      Pars Distalis, Pigmentation          |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 1|             
                             DAY ON TEST   | 3| 2| 2| 6| 2| 2| 2| 9| 3| 2| 2| 2| 2| 6| 6| 2| 3| 2| 0| 6| 2| 2| 2| 0| 9|             
                                           | 1| 9| 4| 4| 4| 4| 4| 1| 1| 9| 4| 4| 5| 6| 6| 4| 1| 5| 3| 4| 3| 9| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0% MF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Angiectasis         |                         3                             1                  |             
      Pars Intermedia, Cyst                |                                  2                 1           2  1      |             
      Pars Intermedia, Pigmentation        |                                                                          |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +  +  +        +  +  +           +  +  +  +     +  +  +  +   |             
      C-Cell, Hyperplasia                  |    1  1     2  1  1        1  1  1           1  1  1  1     2  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +                 +                 +                 +        +     +   |             
      Cyst                                 |                   3                                                      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                   1                                   2                  |             
      Inflammation, Chronic Active         | 3                                                                    3   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M  M     M  M  M     M  M  M  +  M        M  M  M  +     +  M  M  +   |             
      Congestion                           |                                                                          |             
      Periovarian Tissue, Cyst             | 4                                3                          2            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +     +  +  +  +   |             
      Cyst                                 |                2                                                         |             
      Hydrometra                           |                                                       3                  |             
      Inflammation, Chronic Active         |                               1                                          |             
      Endometrium, Hyperplasia             | 1                                               2                 2      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                       +              +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +                 +              +   |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                       +              +   |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +                 +              +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 1|             
                             DAY ON TEST   | 3| 2| 2| 6| 2| 2| 2| 9| 3| 2| 2| 2| 2| 6| 6| 2| 3| 2| 0| 6| 2| 2| 2| 0| 9|             
                                           | 1| 9| 4| 4| 4| 4| 4| 1| 1| 9| 4| 4| 5| 6| 6| 4| 1| 5| 3| 4| 3| 9| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0% MF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                          |             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                     2                 1              2   |             
      Pigmentation                         |                                     1                 1              1   |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +                                      +        +              +   |             
      Depletion Lymphoid                   |                                                       2                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                | 3  4                                                                     |             
      Inflammation, Chronic, Granulomatous | 3  3                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                       +              +   |             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +           +     +                             +     +        +  +  +   |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          | 2           3     3                             3     2              2   |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                       +              +   |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                       +              +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                       +              +   |             
      Hydrocephalus                        |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +                          +              +        +        +     +   |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                              1                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                              2                           |             
      Artery, Mineralization               |                               1                       1                  |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                       +              +   |             
      Glands, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                       +              +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 1|             
                             DAY ON TEST   | 3| 2| 2| 6| 2| 2| 2| 9| 3| 2| 2| 2| 2| 6| 6| 2| 3| 2| 0| 6| 2| 2| 2| 0| 9|             
                                           | 1| 9| 4| 4| 4| 4| 4| 1| 1| 9| 4| 4| 5| 6| 6| 4| 1| 5| 3| 4| 3| 9| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0% MF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                       +           +            |             
      Cataract                             |                         3                                   4            |             
      Synechia                             |                         3                                   4            |             
      Retina, Degeneration                 |                         4                       2           4            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +     +  +  +  +   |             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          | 3  1  2     2  2  3     2  2  2  2  1        2  2  2  2     2  2  3  1   |             
      Artery, Thrombosis                   |                                                                          |             
      Papilla, Necrosis, Coagulative       |                2                                                         |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                                                          |             
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                            2     2                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4|              |            |
                             DAY ON TEST   | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4|              |            |
                                           | 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    1.0% MF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                         +  +           +                 +               |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                         +  +           +                 +               |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                         +  +           +                 +               |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                         +  +           +                 +               |   7        |
      Parasite Metazoan                    |                                                          1               |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                         +  +           +                 +               |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +     +  +     +  +  +  +  +  +        +        +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +     +  +     +  +  +  +  +  +        +        +               |  50        |
      Autolysis                            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +     +  +     +  +  +  +  +  +        +        +               |  49        |
      Epithelium, Pigmentation             |       2        1                                                         |     19  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +     +  +     +  +  +  +  +  +        +        +               |  49        |
      Autolysis                            |                                                                          |      1  4.0|
      Epithelium, Pigmentation             |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +     +  +     +  +  +  +  +  +        +        +               |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     | 1     2  1     1           1  2  1  1           1                        |     41  1.4|
      Clear Cell Focus                     |       1                                                                  |      4  1.0|
      Cyst Multilocular                    |                                                                          |      1  3.0|
      Degeneration                         |                                                                          |      1  2.0|
      Fatty Change                         |                1  2     2           2  4                                 |     12  1.7|
      Granuloma                            |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |          X                                                               |      5  1.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic, Granulomatous |                                                                          |     10  1.1|
      Inflammation, Chronic                | 1                                   2                                    |      3  1.3|
      Inflammation, Chronic Active         |                            1                                             |      2  1.0|
      Mixed Cell Focus                     |                                                                          |      4  2.3|
      Necrosis, Coagulative                | 1                 1                                                      |      5  1.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                1  1              1     1        1                        |     17  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +        M                                                      |   2        |
      Fibrosis                             |                                                                          |      1  4.0|
      Inflammation, Chronic, Granulomatous |          4                                                               |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Pigmentation                         |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +     +  +     +  +  +  +  +  +        +        +               |  50        |
      Atrophy                              | 2                       2        1     1                                 |     21  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4|              |            |
                             DAY ON TEST   | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4|              |            |
                                           | 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    1.0% MF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Cytoplasmic Alteration               |                                                                          |      4  1.3|
      Inflammation, Chronic                | 1        1              1        1                                       |     22  1.0|
      Artery, Hyperplasia                  | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                         +  +           +                 +               |   7        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +     +  +     +  +  +  +  +  +        +        +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +     +  +     +  +  +  +  +  +        +        +               |  50        |
      Acanthosis                           |                                                                          |      3  1.3|
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Hyperplasia, Basal Cell              |                                                                          |      3  1.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Necrotizing                      |                                                                          |      1  4.0|
      Artery, Mineralization               |                1                                                         |      1  1.0|
      Muscularis, Mineralization           |                1                                                         |      3  1.0|
      Submucosa, Mineralization            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +     +  +     +  +  +  +  +  +        +        +               |  50        |
      Artery, Mineralization               |                                                                          |      1  2.0|
      Epithelium, Pigmentation             |                                                 1                        |      8  1.4|
      Mucosa, Dilatation                   |                                                                          |      5  1.6|
      Muscularis, Mineralization           | 1                                                                        |      6  1.7|
                                            __________________________________________________________________________|____________|
   Tongue                                  | +     +  +     M  M     +  +  +  +  M  +        +        +               |  43        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |          1                       1                                       |     12  1.0|
      Arteriole, Necrosis, Fibrinoid       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                         +  +           +                 +               |   7        |
      Cardiomyopathy                       |                            1                                             |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                   +     +  +           +                 +               |  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                   +     +  +           +                 +               |  13        |
      Angiectasis                          |                         1                                                |      2  1.0|
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  1.0|
      Vacuolization Cytoplasmic            |                   1     3              4                                 |      3  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                         +  +           +                 +               |  12        |
      Angiectasis                          |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                         +  +           +                 +               |   8        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4|              |            |
                             DAY ON TEST   | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4|              |            |
                                           | 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    1.0% MF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M     +  M     +  M     +  M  +  M  +  +        +        M               |  36        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +     +  +     +  +  +  +  +  +        +        +               |  50        |
      Pars Distalis, Angiectasis           |                   1              4  2                                    |     12  2.3|
      Pars Distalis, Cyst                  | 1     4        3        1     2  2     2        2                        |     23  2.0|
      Pars Distalis, Cyst, Multiple        |                                                          X               |      1     |
      Pars Distalis, Hyperplasia           | 1        2              1                                                |     18  1.8|
      Pars Distalis, Infiltration Cellular,|                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Pars Distalis, Pigmentation          |                   1                                                      |      3  1.7|
      Pars Intermedia, Angiectasis         |                                                                          |      4  1.8|
      Pars Intermedia, Cyst                |                                                                          |      7  1.3|
      Pars Intermedia, Pigmentation        |                   1                                                      |      1  1.0|
      Pars Nervosa, Cyst                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +     +  +     +  +  +  +  +  +        +        +               |  47        |
      C-Cell, Hyperplasia                  | 1     1        1  1           1  1  1           1                        |     40  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                   +     +  +           +                 M               |  14        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                            1                                             |      4  1.3|
      Inflammation, Chronic Active         |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | M     M  M     +  M     +  +  M  M  M  +        M        +               |  15        |
      Congestion                           |                2                                                         |      1  2.0|
      Periovarian Tissue, Cyst             |                         3  2                                             |      9  3.2|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +     +  +     +  +  +  +  +  +        +        +               |  50        |
      Cyst                                 |                                                                          |      3  2.3|
      Hydrometra                           | 3                          1                                             |      5  2.6|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Endometrium, Hyperplasia             |       1                                                                  |      8  1.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                         +  +           +                 +               |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +        +     +  +     +     +                 +               |  17        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4|              |            |
                             DAY ON TEST   | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4|              |            |
                                           | 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    1.0% MF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hemorrhage              |          1                                               2               |      3  2.0|
      Mediastinal, Pigmentation            |          2                                                               |      1  2.0|
      Pancreatic, Ectasia                  |          3                                                               |      1  3.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |          2                                                               |      2  2.0|
      Pancreatic, Pigmentation             |          1                                                               |      2  1.5|
      Renal, Hemorrhage                    |          2                                                               |      2  1.5|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |          2                                                               |      2  2.0|
      Renal, Pigmentation                  |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                         M  +     +     +                 +               |  10        |
      Hemorrhage                           |                                  4                                       |      3  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +              +  +           +                 +               |  12        |
      Angiectasis                          |                                                          4               |      1  4.0|
      Ectasia                              |                                                                          |      1  2.0|
      Hemorrhage                           |          1                                                               |      2  1.5|
      Infiltration Cellular, Histiocyte    |          1              1              1                 1               |     10  1.3|
      Pigmentation                         |          1              1              1                                 |      8  1.0|
      Thrombosis                           |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                 +     +  +           +                 +               |  20        |
      Depletion Lymphoid                   |                         2              2                                 |      4  2.3|
      Hematopoietic Cell Proliferation     |                                                          2               |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  3.3|
      Inflammation, Chronic, Granulomatous |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                         +  +           +                 +               |   7        |
      Depletion Lymphoid                   |                                                          2               |      1  2.0|
      Hemorrhage                           |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +        +        +  M        +  +        +        +               |  24        |
      Galactocele                          |                                                                          |      1  2.0|
      Hyperplasia                          |                2        2              3                 2               |     13  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    |                         +  +           +                 +               |   8        |
      Inflammation, Acute, Necrotizing     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                         +  +           +                 +               |   7        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4|              |            |
                             DAY ON TEST   | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4|              |            |
                                           | 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    1.0% MF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                         +  +           +                 +               |   8        |
      Hydrocephalus                        |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +        +     +  +        +  +                 +               |  20        |
      Foreign Body                         |                                                                          |      1  1.0|
      Hemorrhage                           |                   2        2                                             |      2  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      3  1.3|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Leukocytosis                         |                                                          3               |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
      Artery, Mineralization               |          1                             1                 1               |      6  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                         +  +           +                 +               |   7        |
      Glands, Inflammation, Acute          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                         +  +           +                 +               |   7        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +              I              +                                 |   6        |
      Cataract                             |                                                                          |      3  3.7|
      Synechia                             |                                                                          |      3  3.7|
      Retina, Degeneration                 |                                                                          |      4  3.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   2        |
      Hemorrhage                           |          1                                                               |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +     +  +     +  +  +  +  +  +        +        +               |  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Inflammation, Chronic                | 2                                                                        |      1  2.0|
      Nephropathy                          | 3     3  2     1  2     2  1  2  3  2  1        2        1               |     50  2.1|
      Artery, Thrombosis                   | 2                                                                        |      1  2.0|
      Papilla, Necrosis, Coagulative       |                                                                          |      1  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Pigmentation                    |                   2                                                      |      1  2.0|
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia            |                                                                          |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4|              |            |
                             DAY ON TEST   | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4|              |            |
                                           | 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|              |      A     |
    1.0% MF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Transitional Epithelium, Hyperplasia |                                  2                                       |      5  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +     +  +     +  +  +  +  +  +        +        +               |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|             
                                           | 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    4.0% HF                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M     +     +  +     +  +  +  +  +  +  M  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +     +  +     +  +     +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +     +  +     +  +     +  +  +  +  +  +  +  +  +  +  +      |             
      Necrosis, Acute, Coagulative         |                                                                          |             
      Parasite Metazoan                    |                                     X        1                    1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +     +  +     +  +     +  +  +  +  +  +  +  +  +  +  +      |             
      Parasite Metazoan                    |                                                 1                 1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +     +  +     +  +     +  +  +  +  +  +  +  +  +  +  +      |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +     +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +     +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +      |             
      Epithelium, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +     +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +      |             
      Epithelium, Pigmentation             | 2  2              1  2        2        2  2  1  2  2  2  2  2  2  2      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +     +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +      |             
      Epithelium, Pigmentation             | 2  2              1                    2  1        1           2         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Basophilic Focus                     | 1  1        1     1  1        1  1  1  1  1  1  1  1  1  1  1  1  1      |             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                                    3                     |             
      Developmental Malformation           | X                                                     X                  |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                            3                       1        1            |             
      Fibrosis, Focal                      |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic, Granulomatous |                   1                 1                       1            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |       1     1                 1           1                              |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |       1     1                                                            |             
      Bile Duct, Cyst Multilocular         |                                                                          |             
      Bile Duct, Hyperplasia               |    1  1           1                 1              2  1  1        1      |             
      Centrilobular, Necrosis, Coagulative |                                  3                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Atrophy                              | 2     1              1                    1  1     1                     |             
      Cytoplasmic Alteration               |                                                                          |             
      Ectopic Liver                        |                            X                                             |             
      Inflammation, Chronic                | 1     1              1        1           1  1     1                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +                          +  +                                    |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Acanthosis                           |                            2              1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|             
                                           | 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    4.0% HF                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                            2                                             |             
      Hyperplasia, Basal Cell              |                                                                   2      |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                            4                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Pigmentation             | 2  2        1     1  2        2     1  2  1  1  2  1  2  2  2  2  2      |             
      Mucosa, Dilatation                   |                                           1                              |             
      Muscularis, Mineralization           |                                              1     1                     |             
                                            __________________________________________________________________________|             
   Tongue                                  | +  +  +     +     +  +     +  +  +  +  +     +     +  +     +  +  +      |             
      Inflammation, Chronic                |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Cardiomyopathy                       | 4  2  1     1     1  1     2  1  2  1  2  1  1  1  2  2  1  1  1  2      |             
      Atrium Left, Thrombosis              |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
      Coronary Artery, Necrosis, Fibrinoid |                                                                          |             
      Epicardium, Fibrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Angiectasis                          |    1        1     1        1  1     1  2  1  1        1        1         |             
      Hyperplasia                          | 1                          1  1              2  1           1     1      |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            | 1           1              2  1        1  1  1  1           2     1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia                          |                                     1                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +     +  +     +  +     +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +     +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +      |             
      Angiectasis                          |       1                                                                  |             
      Hyperplasia                          |                                                                          |             
      Pars Distalis, Angiectasis           |                      3                 1     2                 2  1      |             
      Pars Distalis, Cyst                  | 1  1  1     4     1  3     2           1  1  1     3     3     2  2      |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Hyperplasia           | 1     1           1  1     2                          2  2     1  2      |             
      Pars Intermedia, Angiectasis         |    3              2           1                 1                        |             
      Pars Intermedia, Cyst                |                                                    1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|             
                                           | 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    4.0% HF                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Ultimobranchial Cyst                 |                                                             1            |             
      C-Cell, Hyperplasia                  |    1        1     1  2     1  1     1  1  1  1     1     1  1  1  1      |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +                    +  +  +  +                                    |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                                     1                                    |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +      |             
      Cyst                                 |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hydrometra                           |       1              1                       2  2              3  3      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                    2                     |             
      Metaplasia, Squamous                 |                                                                          |             
      Endometrium, Hyperplasia             |       1                                                           2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +                          +  +                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  M      |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                                          |             
      Lumbar, Pigmentation                 |                                                                          |             
      Mediastinal, Depletion Lymphoid      |                                  4                                       |             
      Mediastinal, Hemorrhage              |                                  1  1                    1               |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Necrosis, Coagulative   |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hemorrhage               |                                           1                              |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Pigmentation             |                                           2                              |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |    3                                                                     |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +     +  +     +  +  +  M  +  M  +  +  +  +  +  +  +  M      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|             
                                           | 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    4.0% HF                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ectasia                              |             1                                2           2               |             
      Hemorrhage                           | 2                 1  4                 3     1     2  1                  |             
      Infiltration Cellular, Histiocyte    |                                                                1         |             
      Pigmentation                         |                                                                1         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                             A  +                                    |             
      Ectasia                              |    3                                                                     |             
      Infiltration Cellular, Histiocyte    |    2                                1                                    |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |    1                                1                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Depletion Lymphoid                   |                            2     3  1              3     4        1      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic, Granulomatous |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +                          +  M                                    |             
      Depletion Lymphoid                   |       3                          3                                       |             
      Necrosis, Coagulative                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +                    +  +  +  +     +     +     +        +         |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |       1                    2  2  1  2                                    |             
                                            __________________________________________________________________________|             
   Skin                                    |       +                          +  +                                    |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +                       +     +                          +         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hemorrhage                           |                               1     1                                    |             
      Hydrocephalus                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hemorrhage                           |                                     1                                    |             
      Infiltration Cellular, Histiocyte    |       1                                   1     1  1  1           1      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|             
                                           | 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    4.0% HF                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                 2                        |             
      Artery, Mineralization               |                                     1     1  1                 1  1      |             
                                            __________________________________________________________________________|             
   Nose                                    |       +                          A  +                                    |             
      Capillary, Submucosa, Thrombosis     |                                                                          |             
      Glands, Inflammation, Acute          |                                     1                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                             +                                       |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Congestion                           |                                                                          |             
      Nephropathy                          | 3  3        2     2  3     4  3     2  2  2  2  3  2  2  1  2  2  2      |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|             
                                           | 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    4.0% HF                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Necrosis, Acute, Coagulative         |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Parasite Metazoan                    |                                                       1                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     M        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Epithelium, Pigmentation             |                                              1                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Epithelium, Pigmentation             |    2     1              1     1  1           1  2              2     1   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Epithelium, Pigmentation             | 1                 1     1        1  2                 2        2     1   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Basophilic Focus                     | 1  1              1           1  1        1  1        1        1  1      |             
      Clear Cell Focus                     |                               1              1                           |             
      Cyst                                 |                                     2                                    |             
      Cytoplasmic Alteration               |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |                                  2                                       |             
      Fatty Change                         |                                                 1                    1   |             
      Fibrosis, Focal                      | 2                                                                        |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic, Granulomatous |    1                                                           1  1      |             
      Inflammation, Chronic                |          1                                1                              |             
      Inflammation, Chronic Active         |                                                                          |             
      Mixed Cell Focus                     |                                                                1         |             
      Necrosis, Coagulative                |          1                       1                                       |             
      Bile Duct, Cyst Multilocular         | X                                                                        |             
      Bile Duct, Hyperplasia               |          1                          1     1                          1   |             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Atrophy                              |                               1     3     1                          1   |             
      Cytoplasmic Alteration               |                                                 1                 2      |             
      Ectopic Liver                        |                                                                          |             
      Inflammation, Chronic                |                               1           1        1              1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                   +     +           +     +           +              +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Acanthosis                           |    2                                      2     3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|             
                                           | 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    4.0% HF                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |    2                                            2  1                     |             
      Hyperplasia, Basal Cell              |    2                                            2  1                     |             
      Inflammation, Chronic Active         |                                                 4                        |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Cyst Epithelial Inclusion            |                               3                                          |             
      Inflammation, Chronic Active         |                                     2                                    |             
      Epithelium, Pigmentation             | 1  2     1        2     1     2  2           2        2        2     1   |             
      Mucosa, Dilatation                   | 1                                               2                 1      |             
      Muscularis, Mineralization           | 1                                                                        |             
                                            __________________________________________________________________________|             
   Tongue                                  | +  +     +        +           +  +  +     +  +  +     +        +         |             
      Inflammation, Chronic                |    1     1                                   1                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Cardiomyopathy                       | 1  1     1        1     1     1  1        2  4  2  1  1        2  2      |             
      Atrium Left, Thrombosis              |                                           4                              |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                               4                                          |             
      Coronary Artery, Necrosis, Fibrinoid |                                                                          |             
      Epicardium, Fibrosis                 |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Angiectasis                          | 1  1     1        2           2  1           2        1        1         |             
      Hyperplasia                          |                               1                 1  2              3      |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            | 1        1              2                 1     1  1              1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Hyperplasia                          | 2                                         2                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     M        +     +     +  +  M     M  M  M  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Pars Distalis, Angiectasis           |    1                                         1                           |             
      Pars Distalis, Cyst                  | 2  4                          3           1        2           2         |             
      Pars Distalis, Cyst, Multiple        |                                     3                                    |             
      Pars Distalis, Hyperplasia           | 1                             1                                          |             
      Pars Intermedia, Angiectasis         |          3                                      3                        |             
      Pars Intermedia, Cyst                | 1                       1                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|             
                                           | 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    4.0% HF                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Ultimobranchial Cyst                 |                                     1                                    |             
      C-Cell, Hyperplasia                  | 1  1     1        1           1     1        1  1              1  1  1   |             
      Follicle, Cyst                       |    2                                                  2              2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |          +              +           +     +                              |             
      Abscess                              |          4                                                               |             
      Inflammation, Chronic                |                         2                 1                              |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Cyst                                 |                                              2                           |             
      Periovarian Tissue, Cyst             |    3     1              X                 3                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Hydrometra                           |    3              2                 2                                3   |             
      Inflammation, Acute                  |                                           2                              |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Endometrium, Hyperplasia             |    2              1                                            2     2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                   +     +           +     +           +              +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                                          |             
      Lumbar, Pigmentation                 |                                                                          |             
      Mediastinal, Depletion Lymphoid      |                                                                          |             
      Mediastinal, Hemorrhage              | 2                                                  2                     |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Necrosis, Coagulative   |                                     4                                    |             
      Mediastinal, Pigmentation            |                                                    2                     |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +        +     M     +  +  +     +  +  +  +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|             
                                           | 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    4.0% HF                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |    1     2                       3        2                              |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +     M                 +           +              +   |             
      Ectasia                              |                                                                          |             
      Infiltration Cellular, Histiocyte    |                   2                       1           1              1   |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |                   1                       1           1              1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Depletion Lymphoid                   |                         2                          3                 4   |             
      Hematopoietic Cell Proliferation     |                         3                                                |             
      Inflammation, Chronic, Granulomatous |    2                                                                     |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                   +     +           +     M           +              +   |             
      Depletion Lymphoid                   |                   3     2                             3                  |             
      Necrosis, Coagulative                |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          +        +     +           +     +           +        +     +   |             
      Galactocele                          |                   3                                                      |             
      Hyperplasia                          |                   2                 2     2           2              2   |             
                                            __________________________________________________________________________|             
   Skin                                    |                   +     +           +     +           +              +   |             
      Subcutaneous Tissue, Edema           |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                   +     +        +  +     +           +              +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +     +                       +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                       2                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                   +      |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Hemorrhage                           |                                           2                              |             
      Infiltration Cellular, Histiocyte    | 1        1              1     1           2                       1      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                           2                              |             
      Inflammation, Chronic Active         |                                                                      2   |             
      Pigmentation                         |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|             
                                           | 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    4.0% HF                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Mineralization               |    1     1        1           1                 1     1           1      |             
                                            __________________________________________________________________________|             
   Nose                                    |                   +     +           +     +           +              +   |             
      Capillary, Submucosa, Thrombosis     |                                                                          |             
      Glands, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
      Cataract                             |                                                       2                  |             
      Retina, Degeneration                 |                                                       3                  |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                   +                  |             
      Inflammation, Chronic                |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Congestion                           |                                           2                              |             
      Nephropathy                          | 3  2     3        2     1     3  3  2     1  3  4  2  2        1  2  1   |             
      Renal Tubule, Hyperplasia            |                               1                                          |             
      Transitional Epithelium, Hyperplasia |                                                                   2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +        +     +     +  +  +     +  +  +  +  +        +  +  +   |             
      Hemorrhage                           |                                                                   4      |             
      Inflammation, Acute                  |                                                                   3      |             
      Transitional Epithelium, Hyperplasia |                                                                   2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4|              |            |
                             DAY ON TEST   | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6|              |            |
                                           | 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    4.0% HF                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +     +  +  +  +        +  +  +  +  +  +                        |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  48        |
      Necrosis, Acute, Coagulative         |                                  2                                       |      1  2.0|
      Parasite Metazoan                    |                      1                                                   |      4  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  48        |
      Parasite Metazoan                    |                                           1  1                           |      5  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  47        |
      Parasite Metazoan                    |          1                                1                              |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  49        |
      Epithelium, Pigmentation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  49        |
      Epithelium, Pigmentation             |    1  2        2  2  2  1                    1  1                        |     32  1.6|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  49        |
      Epithelium, Pigmentation             |                   1     1           1     1     1                        |     20  1.4|
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
      Basophilic Focus                     |    1  1        1  1  1  1           1     1  1  1  1                     |     39  1.0|
      Clear Cell Focus                     |                                                                          |      2  1.0|
      Cyst                                 |                                        4                                 |      2  3.0|
      Cytoplasmic Alteration               |                                                                          |      1  3.0|
      Developmental Malformation           |                                                                          |      2     |
      Eosinophilic Focus                   |       1                                   4                              |      3  2.3|
      Fatty Change                         |                                  1           1                           |      7  1.3|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Infarct                              |                                        4                                 |      1  4.0|
      Inflammation, Chronic, Granulomatous |                      2                             1                     |      8  1.1|
      Inflammation, Chronic                |                                     1                                    |      3  1.0|
      Inflammation, Chronic Active         |       1                 1              1                                 |      7  1.0|
      Mixed Cell Focus                     |                                                                          |      1  1.0|
      Necrosis, Coagulative                |    1                    1        3     1                                 |      8  1.3|
      Bile Duct, Cyst Multilocular         |                                                                          |      1     |
      Bile Duct, Hyperplasia               |          1                       2     2                                 |     15  1.2|
      Centrilobular, Necrosis, Coagulative |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
      Atrophy                              |          3           1  1        1  1                                    |     15  1.3|
      Cytoplasmic Alteration               |                                                                          |      2  1.5|
      Ectopic Liver                        |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4|              |            |
                             DAY ON TEST   | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6|              |            |
                                           | 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    4.0% HF                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |    2              1  1  1                       1  1                     |     17  1.1|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                  +  +                                    |  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +     +  +  +  +        +  +  +  +  +     +                     |  47        |
      Acanthosis                           |                                        2  2                              |      7  2.0|
      Edema                                |                                           4                              |      1  4.0|
      Hyperkeratosis                       |          2                             2  2                              |      7  1.9|
      Hyperplasia, Basal Cell              |                                        1                                 |      5  1.6|
      Inflammation, Chronic Active         |                                           2                              |      2  3.0|
      Ulcer                                |                                  2                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Epithelium, Pigmentation             |    1  2        2  2  1  2           2        2  1  2                     |     38  1.7|
      Mucosa, Dilatation                   |                                                                          |      4  1.3|
      Muscularis, Mineralization           |    1                                                                     |      4  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |    +  +        +  +                 +  +  +  +  +  +                     |  39        |
      Inflammation, Chronic                |    1                                            1                        |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
      Cardiomyopathy                       |    2  2  2     2  2  2  1           1  1  1  1  1  2                     |     47  1.5|
      Atrium Left, Thrombosis              |                                                                          |      1  4.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      1  4.0|
      Coronary Artery, Necrosis, Fibrinoid |    2                                                                     |      1  2.0|
      Epicardium, Fibrosis                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
      Angiectasis                          |    2           2     1              1        1     2                     |     26  1.3|
      Hyperplasia                          |                   2     1                 1     2                        |     15  1.4|
      Necrosis, Coagulative                |                                  2                                       |      1  2.0|
      Vacuolization Cytoplasmic            |    1     1        1  1                    1  1  1                        |     24  1.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
      Hyperplasia                          |                                              2                           |      4  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +     +  +  +  +        M  +  +  +  +  +  +                     |  43        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4|              |            |
                             DAY ON TEST   | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6|              |            |
                                           | 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    4.0% HF                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  49        |
      Angiectasis                          |                                                                          |      1  1.0|
      Hyperplasia                          |          1              1                                                |      2  1.0|
      Pars Distalis, Angiectasis           |                   1                                                      |      8  1.5|
      Pars Distalis, Cyst                  |    1  2  2                       2     1  1     1  2                     |     28  1.9|
      Pars Distalis, Cyst, Multiple        |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |    2              2                                                      |     13  1.5|
      Pars Intermedia, Angiectasis         |                                                                          |      6  2.2|
      Pars Intermedia, Cyst                |          2                       1              1                        |      6  1.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
      Ultimobranchial Cyst                 |                   X                                                      |      3  1.0|
      C-Cell, Hyperplasia                  |    1     1     1  1  1              1  1  1  1  1  1                     |     37  1.0|
      Follicle, Cyst                       |                                              1                           |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                         +        +  +                                    |  12        |
      Abscess                              |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                     1                                    |      4  1.3|
      Inflammation, Chronic Active         |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +     +  +  +  +        +  +  +  +  +  M  +                     |  48        |
      Cyst                                 |                                                    2                     |      2  2.0|
      Periovarian Tissue, Cyst             |                                                    4                     |      5  2.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
      Hydrometra                           |                                  2     4     2  3                        |     14  2.4|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |                                        3                                 |      1  3.0|
      Endometrium, Hyperplasia             |                      2                                                   |      7  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                  +  +                                    |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  49        |
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |                                        1                                 |      1  1.0|
      Lumbar, Pigmentation                 |                                        1                                 |      1  1.0|
      Mediastinal, Depletion Lymphoid      |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4|              |            |
                             DAY ON TEST   | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6|              |            |
                                           | 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    4.0% HF                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hemorrhage              |    3                                2                                    |      7  1.7|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                           2                              |      1  2.0|
      Mediastinal, Necrosis, Coagulative   |                                                                          |      1  4.0|
      Mediastinal, Pigmentation            |                                           2                              |      2  2.0|
      Pancreatic, Ectasia                  |    2                                                                     |      1  2.0|
      Pancreatic, Hemorrhage               |    2                                                                     |      2  1.5|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |    2                                            2                        |      2  2.0|
      Pancreatic, Pigmentation             |    2                                            2                        |      3  2.0|
      Renal, Hemorrhage                    |    2           3                          1                              |      3  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |    2           3                          2                              |      4  2.5|
      Renal, Pigmentation                  |    2           3                          2                              |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  46        |
      Ectasia                              |                                  1     2  1                              |      6  1.5|
      Hemorrhage                           |    1  2           1                 1           2  2                     |     17  1.8|
      Infiltration Cellular, Histiocyte    |                   1                                                      |      2  1.0|
      Pigmentation                         |                   1                                                      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +                       +  +                                    |   9        |
      Ectasia                              |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                     1                                    |      7  1.3|
      Necrosis, Coagulative                |          4                                                               |      1  4.0|
      Pigmentation                         |                                     1                                    |      7  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
      Depletion Lymphoid                   |                                                                          |      9  2.6|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Inflammation, Chronic, Granulomatous |                                                                          |      1  2.0|
      Necrosis                             |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          M                       +  +                                    |   9        |
      Depletion Lymphoid                   |                                  4  3                                    |      7  3.0|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                      +  +        +  +              +                     |  22        |
      Galactocele                          |                                                                          |      1  3.0|
      Hyperplasia                          |                         2        1  2                                    |     13  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                  +  +                                    |  11        |
      Subcutaneous Tissue, Edema           |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4|              |            |
                             DAY ON TEST   | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6|              |            |
                                           | 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    4.0% HF                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                   +              +  +                                    |  14        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
      Hemorrhage                           |                                                                          |      2  1.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                  +                                       |   2        |
      Hemorrhage                           |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
      Hemorrhage                           |                                  1  1                                    |      4  1.3|
      Infiltration Cellular, Histiocyte    |       1  1        1     1        1        1                              |     18  1.1|
      Inflammation, Acute                  |    1                                                                     |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Artery, Mineralization               |          1        1                                                      |     14  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                  +  +                                    |  10        |
      Capillary, Submucosa, Thrombosis     |                                  2                                       |      1  2.0|
      Glands, Inflammation, Acute          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +  +                              |   5        |
      Cataract                             |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                           3                              |      2  3.0|
      Sclera, Metaplasia, Osseous          |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Nephropathy                          |    3  3  1     2  4  4  2        1  1  2  4  3  3  2                     |     48  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4|              |            |
                             DAY ON TEST   | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6|              |            |
                                           | 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    4.0% HF                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |    1     2                       2                                       |      4  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +     +  +  +  +        +  +  +  +  +  +  +                     |  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|             
                             DAY ON TEST   | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|             
                                           | 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  A     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  A     +|             
      Parasite Metazoan                    |                                                                1         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  A     +|             
      Parasite Metazoan                    |                1                 1                          2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  A     +|             
      Parasite Metazoan                    |                                  1                    1                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  A     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +     +        +  +  +  +  M  +  +  +  +     +  +  A     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  M  +     +  +  A     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  A  +     +        +  +  +  +  +  +  +  +  +     +  +  A     +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Basophilic Focus                     |       1        1                                            1           1|             
      Clear Cell Focus                     |       1        1              2                             1            |             
      Congestion                           |                                           2                              |             
      Cytoplasmic Alteration               |                      2                             2                     |             
      Degeneration, Cystic                 |                                                                          |             
      Degeneration                         |                      1                                                   |             
      Eosinophilic Focus                   |                1                             2                          1|             
      Fatty Change                         |             3                             2                              |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                           2                              |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Focal                   |                                                 3                        |             
      Inflammation, Chronic                |       1                       1  2           1                          1|             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |             3                                      2                     |             
      Bile Duct, Hyperplasia               |    2  2  1  1  1              2  2  3  2     1  3     1     1  2  2     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +        +                 +                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Coagulative                |    3                                                                     |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Atrophy                              |                               1  2  2  1     1              1  1  1     3|             
      Inflammation, Chronic                |       1     1  1     1        1  2           1  1     1     1  1        2|             
      Pigmentation                         |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  M  +  +  +     +        +  +  +  +  +  +     M                     |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +     +        +  +  +  +  +  M  +  +  +     +  +  +     +|             
      Hyperplasia, Basal Cell              |                               1                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|             
                             DAY ON TEST   | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|             
                                           | 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Muscularis, Mineralization           |       2                                                                  |             
      Submucosa, Fibrosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |    +  +     M  +     +        +  +     +  +  +  +  +  +     M  +  +     +|             
      Metaplasia, Osseous                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
      Aorta, Mineralization                |                                                    1                     |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Cardiomyopathy                       |    1  1  1  1  2     1        3  2  3  3  1  2  2  1  2     2  2  2     3|             
      Thrombosis                           |             3                                                            |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Angiectasis                          |                                                             1            |             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                    3                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |       2  1                    1                 2                        |             
      Vacuolization Cytoplasmic            |    2     1  2        1                 1  2  1  2  3           1         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |    3                                2           1     3        1         |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +     +        +  +  +  +  M  +  +  +  +     +  +  M     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  A  M  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Pars Distalis, Angiectasis           |                                                 2                        |             
      Pars Distalis, Cyst                  |       2                                   1        1                     |             
      Pars Distalis, Hyperplasia           |    1  2              2           2        1  1  2                        |             
      Pars Intermedia, Cyst                |    1                          1                 1           1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Inflammation, Acute                  |                                                                          |             
      Ultimobranchial Cyst                 |                      1                                                   |             
      C-Cell, Hyperplasia                  |    2  1                       2     1                 2     1  1         |             
      Follicle, Pigmentation               |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|             
                             DAY ON TEST   | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|             
                                           | 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                        +  +                              |             
      Adventitia, Inflammation, Chronic    |                                                                          |             
          Active                           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     M  +        +                    +                              |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |    2        2        2                    1                              |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +     +        M  +  +  +  +  +  +  +  +     +  +  +     +|             
      Inflammation, Chronic Active         |    1        1        1                 4                    2  1  2     3|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Atrophy                              |    2  2        3              3  3  3        2  2  2  2     2  3        2|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Necrosis, Coagulative                |                                                                3         |             
      Interstitial Cell, Hyperplasia       |    1  1     1  1                    1     1  1  1           1  1         |             
      Seminiferous Tubule, Atrophy         |    3  4     4  4              4  4  2        4  4  4  4     4  4  3     4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +        +                    +                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Lumbar, Ectasia                      |                                                                          |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Mediastinal, Hemorrhage              |             2                                                            |             
      Mediastinal, Pigmentation            |             2                                                            |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Hyperplasia, Plasma Cell |       2                                                                  |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                               2        2                                 |             
      Pancreatic, Pigmentation             |                               2        1                                 |             
      Renal, Ectasia                       |                      4                                                   |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  M  +  M  +     +        +  +  +  +  +  +  +  M  +     +  +  +     +|             
      Angiectasis                          |                                                             3            |             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                 3     2     4           3|             
      Hyperplasia, Plasma Cell             |                3                       2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +        +        +  M  +  M  +     M  +           M  +      |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|             
                             DAY ON TEST   | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|             
                                           | 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                               2                                          |             
      Infiltration Cellular, Histiocyte    |       2     2        2                    1                              |             
      Pigmentation                         |       1     1        1                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |                                        3        4  3           2  3      |             
      Fibrosis                             |                                        2           2                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                     2                 2                  |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  M  +           +           M  +  +  +  M  +  M                     |             
      Depletion Lymphoid                   |                      2                 3  3     3                        |             
      Hemorrhage                           |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M     M  +        +                    M     +                       +|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |             2        2                          1                        |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +        +                 +  +     +                       +|             
      Acanthosis                           |                                                 2                        |             
      Cyst Epithelial Inclusion            |                                        X                                X|             
      Hyperkeratosis                       |                                                 4                        |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +                             +                              |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Hemorrhage                           |                                                                   4      |             
      Cerebellum, Infarct                  |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Hemorrhage                           |                                                       1           2      |             
      Infiltration Cellular, Histiocyte    |       1              1           1  1  1     1     1  1        1  1      |             
      Necrosis, Coagulative                |                                                                          |             
      Artery, Mineralization               |    1  1        1     1        1        1     1  1              1  1     1|             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +     +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|             
                             DAY ON TEST   | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|             
                                           | 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Glands, Inflammation, Acute          |                               1  1                                1      |             
      Lumen, Inflammation, Acute           |    1                                                  2                  |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Chronic                         |          1                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       M                                                                  |             
      Cornea, Fibrosis                     |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Nephropathy                          |    2  4     2  4     3        4  4  2  3  1  2  3  3  3     2  2  2     3|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Epithelium, Pigmentation        |             3                                                            |             
      Renal Tubule, Hyperplasia            |                                                                         2|             
      Transitional Epithelium, Hyperplasia |       2        1              2  1              1                       2|             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |                                                    1                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +     +        +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Calculus Micro Observation Only      |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|             
                                           | 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Parasite Metazoan                    |                                                 1                 1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Parasite Metazoan                    |          1                                   1                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  M   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Basophilic Focus                     |                   1  1                       1     1                     |             
      Clear Cell Focus                     |    1              1  1                                                   |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration, Cystic                 |    1  1           1  1        1                 1                        |             
      Degeneration                         |                                                    1  1                  |             
      Eosinophilic Focus                   |                               2                 1  1  1                  |             
      Fatty Change                         |                                                          1               |             
      Fibrosis                             | 1                 2                                                      |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X                                                      |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                | 1  1  1           1  1        1              1  1  1  1  1               |             
      Mixed Cell Focus                     |                               X                                          |             
      Necrosis, Coagulative                |       2                                               2              1   |             
      Bile Duct, Hyperplasia               | 1  2  1  3        1  1        1  3           1  2  1  1  2     2  1  2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                              +      |             
      Inflammation, Chronic                |    3                                                                     |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |                                                                   1      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Atrophy                              |       1           1           1  2              4                    3   |             
      Inflammation, Chronic                | 1  1  1  1        1  1        1              1  2  1     1     1         |             
      Pigmentation                         |                                                                   3      |             
      Duct, Dilatation                     |                               1                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Hyperplasia, Basal Cell              |                                                                      2   |             
      Inflammation, Chronic Active         |                                                          3               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|             
                                           | 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                          3               |             
      Muscularis, Mineralization           |                                                                          |             
      Submucosa, Fibrosis                  |                                                                      3   |             
                                            __________________________________________________________________________|             
   Tongue                                  | +  +  +  +        +  +        +  +           M  +  +  +  +     +  +  +   |             
      Metaplasia, Osseous                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Cardiomyopathy                       | 2  2  2           2  2        2  3           2  2  2  2  3     3  2  3   |             
      Thrombosis                           |                                              3        3                  |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Angiectasis                          | 1                             1                 2  2              1      |             
      Atrophy                              |                                                                      3   |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                       1                  |             
      Hyperplasia                          |                                                    1                     |             
      Vacuolization Cytoplasmic            |          1        1                                      1     1         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Angiectasis                          |                                                    2              1      |             
      Atrophy                              |                                                                      3   |             
      Hyperplasia                          |       1           1           2  1           2  2  2  2        2  2      |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  M   |             
      Pars Distalis, Angiectasis           |                   1                                                      |             
      Pars Distalis, Cyst                  |                      2                                         1         |             
      Pars Distalis, Hyperplasia           | 2  1  1           1           2                                2         |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Ultimobranchial Cyst                 |                      X                                                   |             
      C-Cell, Hyperplasia                  | 1                    1        1  1           1                 1         |             
      Follicle, Pigmentation               |                                  1                                       |             
      Follicular Cell, Hyperplasia         |                                                    2              1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|             
                                           | 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Adventitia, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                       +                             +     +   |             
      Cyst                                 |                                                                4         |             
      Inflammation, Chronic                |          2                       2                                   3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Inflammation, Chronic Active         | 1  2                          2                 2     1  2           1   |             
      Epithelium, Hyperplasia              |                               2                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Atrophy                              | 2     2           2  2        2  2           3  2  2  3  2     2     3   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Necrosis, Coagulative                |                                                                          |             
      Interstitial Cell, Hyperplasia       | 1  1  1  1        1  1           1           1           1     1  1  1   |             
      Seminiferous Tubule, Atrophy         | 4  2  3  3        4  4        4  3           4  4  4  4        4  4  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +        +  M        +  +           +  +  +  +  +     +  +  +   |             
      Lumbar, Ectasia                      |    2                                                                     |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Mediastinal, Hemorrhage              |       2           2                             2                        |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hemorrhage               |                                  4              1                        |             
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |       2                                                                  |             
      Pancreatic, Pigmentation             |       2                                                                  |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hemorrhage                    |                                  3                                       |             
      Renal, Hyperplasia, Plasma Cell      |                                                          2               |             
      Renal, Pigmentation                  |    2  2                                                              2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +        +  M        +  +           +  +  +  +  +     +  +  +   |             
      Angiectasis                          |                                                                          |             
      Ectasia                              |          2        2                                                      |             
      Hemorrhage                           |    3              2              3                 3                     |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +                    +  +              +        +        +      |             
      Hemorrhage                           |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|             
                                           | 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular, Histiocyte    |       2  1                                               2        2      |             
      Pigmentation                         |       2  1                                               1        1      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |          3                       3                                       |             
      Fibrosis                             |                                                 3              2         |             
      Hematopoietic Cell Proliferation     |                                                       3                  |             
      Infarct                              |                                                                          |             
      Necrosis, Coagulative                |                                                                2         |             
      Pigmentation                         |                                                 3                        |             
                                            __________________________________________________________________________|             
   Thymus                                  |                   +              +                                       |             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +                                               +               |             
      Galactocele                          |    2                                                                     |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +                                                     +         |             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +                                               +               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Cerebellum, Infarct                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Hemorrhage                           |       1                                                                  |             
      Infiltration Cellular, Histiocyte    | 1     1           1  1           1                       1     2  1      |             
      Necrosis, Coagulative                |                                  1                                       |             
      Artery, Mineralization               | 1  1  1              1        1  1           1  1  1  1  1     1     1   |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +           +  +        +              +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|             
                             DAY ON TEST   | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|             
                                           | 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Glands, Inflammation, Acute          |    1                 1        2              1     1                 1   |             
      Lumen, Inflammation, Acute           |                                                                          |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Fibrosis                     |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
      Hyperplasia                          |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Congestion                           |                                                                          |             
      Cyst                                 |                      2                                               3   |             
      Nephropathy                          | 2  3  4  2        4  4        4  3           3  3  2  2  2     3  3  2   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Epithelium, Pigmentation        |          3                       2                                3      |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia |       2           1  2        1  1                             1         |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +        +  +        +  +           +  +  +  +  +     +  +  +   |             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4|              |            |
                             DAY ON TEST   | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6|              |            |
                                           | 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  49        |
      Parasite Metazoan                    |                         1                                                |      4  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  49        |
      Parasite Metazoan                    |                                  1  2              2  1                  |      9  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  49        |
      Parasite Metazoan                    |                               1                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Basophilic Focus                     |                1  X           1  1  1  1  1        1                     |     16  1.0|
      Clear Cell Focus                     |                                                                          |      7  1.1|
      Congestion                           |                                                                          |      1  2.0|
      Cytoplasmic Alteration               |                                                                          |      2  2.0|
      Degeneration, Cystic                 |                                                                          |      6  1.0|
      Degeneration                         |                                                    1                     |      4  1.0|
      Eosinophilic Focus                   |                                  2  3                                    |      9  1.6|
      Fatty Change                         |       3              3                                                   |      5  2.4|
      Fibrosis                             |                                                                          |      2  1.5|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                  X                                       |      2     |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Inflammation, Chronic                | 1  1           1              1  1  1              1  1                  |     24  1.0|
      Mixed Cell Focus                     | 2                                                  2                     |      3  2.0|
      Necrosis, Coagulative                |                                     1                 1                  |      7  1.7|
      Bile Duct, Hyperplasia               | 1  2  1  3     2  2     2     2  1  2  2  1        2  1                  |     46  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +           +                                       |   7        |
      Inflammation, Chronic                |                                  1                                       |      2  2.0|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Atrophy                              | 2  1     2     2        1     2     1  2                                 |     23  1.7|
      Inflammation, Chronic                | 1  1           1        1     2  1  1  2                                 |     32  1.2|
      Pigmentation                         |                                                                          |      1  3.0|
      Duct, Dilatation                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +           +  +                 +           +                  |  16        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4|              |            |
                             DAY ON TEST   | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6|              |            |
                                           | 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  49        |
      Hyperplasia, Basal Cell              |                      1                                                   |      3  1.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Muscularis, Mineralization           |                                                                          |      1  2.0|
      Submucosa, Fibrosis                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  45        |
      Metaplasia, Osseous                  |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Cardiomyopathy                       | 2  2  2  2     2  3  2  2     3  2  3  3           2  2                  |     48  2.1|
      Thrombosis                           |                         4        4     4                                 |      6  3.5|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Angiectasis                          |                                                                          |      6  1.3|
      Atrophy                              |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |    1           1                 1  1                 1                  |     10  1.2|
      Vacuolization Cytoplasmic            | 1  1  2  1     1  1  2  1           1  2  1           1                  |     26  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Angiectasis                          |                                                                          |      2  1.5|
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia                          |                1     2  2        1     2           1  1                  |     22  1.7|
      Necrosis, Coagulative                |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +     +  +  +  +        +  +  +  +        +  +                  |  47        |
      Hyperplasia                          |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +     M  +  +  +     +  +  +  M  M        +  +                  |  43        |
      Hyperplasia                          |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +     +  M  +  +  +        +  +                  |  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4|              |            |
                             DAY ON TEST   | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6|              |            |
                                           | 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Angiectasis           |                                                                          |      2  1.5|
      Pars Distalis, Cyst                  |          X        X                                                      |      7  1.4|
      Pars Distalis, Hyperplasia           | 2              1  1     1                          1                     |     18  1.4|
      Pars Intermedia, Cyst                |          1                          1                                    |      6  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Inflammation, Acute                  |                                  3                                       |      1  3.0|
      Ultimobranchial Cyst                 |                                                                          |      2  1.0|
      C-Cell, Hyperplasia                  |       1           1  1  1                                                |     17  1.2|
      Follicle, Pigmentation               |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   2        |
      Adventitia, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +           +  +                 +           +                  |  13        |
      Cyst                                 |                                                                          |      1  4.0|
      Inflammation, Chronic                |          2           3  2                 3           3                  |     12  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  49        |
      Inflammation, Chronic Active         | 2  1     2           1  1     2  1        3        2  2                  |     25  1.7|
      Epithelium, Hyperplasia              |                                                    2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Atrophy                              | 2     3  3     3  2  2  2     2  3                 3                     |     36  2.4|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       | 1  1     1     1  1  1  1     1     1  1           1  1                  |     34  1.0|
      Seminiferous Tubule, Atrophy         | 4  4  4  4     4  4  3  3     4  4  4  3           4  3                  |     44  3.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +           +  +                 +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  49        |
      Lumbar, Ectasia                      |                                                                          |      1  2.0|
      Lumbar, Hemorrhage                   |          3                                                               |      1  3.0|
      Mediastinal, Hemorrhage              | 2                       3                                                |      6  2.2|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4|              |            |
                             DAY ON TEST   | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6|              |            |
                                           | 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Ectasia                  | 2                                                                        |      1  2.0|
      Pancreatic, Hemorrhage               |          3                                                               |      3  2.7|
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      3  2.0|
      Pancreatic, Pigmentation             |                                                                          |      3  1.7|
      Renal, Ectasia                       |                                                                          |      1  4.0|
      Renal, Hemorrhage                    | 1  2  1                          1                                       |      5  1.6|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  2.0|
      Renal, Pigmentation                  | 2  1                             2                                       |      6  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  46        |
      Angiectasis                          |                                                                          |      1  3.0|
      Ectasia                              |                                                    2                     |      3  2.0|
      Hemorrhage                           |       2                 3           1     3                              |     12  2.7|
      Hyperplasia, Plasma Cell             |                                                    4                     |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +              +                             +                  |  22        |
      Hemorrhage                           |          3              1                                                |      3  1.7|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 2                       2                             2                  |     11  1.8|
      Pigmentation                         | 1                                                     1                  |      9  1.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Congestion                           | 4                                                                        |      1  4.0|
      Depletion Lymphoid                   | 3        3                                                               |      9  3.0|
      Fibrosis                             | 4                    3                                                   |      6  2.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      2  2.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +           +  +                 +           M                  |  14        |
      Depletion Lymphoid                   |          3              3                 3                              |      7  2.9|
      Hemorrhage                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +     +           +  M        +        +           +                  |  13        |
      Galactocele                          |                                                                          |      1  2.0|
      Hyperplasia                          |          2           2                    2           2                  |      7  1.9|
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +     +     +  +           +     +        +  +                  |  20        |
      Acanthosis                           |                                                                          |      1  2.0|
      Cyst Epithelial Inclusion            |                                                                          |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4|              |            |
                             DAY ON TEST   | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6|              |            |
                                           | 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Subcutaneous Tissue, Abscess         |                                                    4                     |      1  4.0|
      Subcutaneous Tissue, Edema           |                         2                                                |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +           +  +                 +           +                  |  10        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Hemorrhage                           |                      1                                                   |      2  2.5|
      Cerebellum, Infarct                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Hemorrhage                           |                   1                                                      |      4  1.3|
      Infiltration Cellular, Histiocyte    | 1  1  1  2     1        1     1  1  1  1  1        1  1                  |     31  1.1|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
      Artery, Mineralization               | 1  1     1     1  1  1  1     1     1     1                              |     34  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +        +  +  +     +  +  +  +  +        +  +                  |  44        |
      Glands, Inflammation, Acute          |                                  1                 1                     |     11  1.1|
      Lumen, Inflammation, Acute           |                                                                          |      2  1.5|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    I  +              +                    I                              |   2        |
      Cornea, Fibrosis                     |                      3                                                   |      1  3.0|
      Retina, Degeneration                 |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Congestion                           |                         2                 1                              |      2  1.5|
      Cyst                                 |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4|              |            |
                             DAY ON TEST   | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6|              |            |
                                           | 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy                          | 3  3     2     3  4  2  2     3  3  3  3  2        4  2                  |     48  2.8|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Epithelium, Pigmentation        |       2                                                                  |      5  2.6|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |    1                                               2                     |     14  1.4|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +     +  +  +  +  +        +  +                  |  50        |
      Calculus Micro Observation Only      |                                        X                                 |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|             
                             DAY ON TEST   | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|             
                                           | 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.1% LM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                        +     +  +  +           +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                        +     +  +  +           +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                        +     +  +  +           +  A      |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                        +     +  +  +           +  +      |             
      Parasite Metazoan                    |                                        1     1                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                        +     +  +  +           +  A      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +              +  +  +  +     +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +              +  +  +  A     +  +  +  +     +  +  M        +  +  A      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +              +  +  +  A     +  +  +  +     +  +  +        +  M  +      |             
      Necrosis, Coagulative                |                                                                          |             
      Epithelium, Pigmentation             |                                                    1                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +              +  +  +  A     +  +  +  +     +  +  M        +  +  A      |             
                                            __________________________________________________________________________|             
   Liver                                   | +              +  +  +  +     +  +  +  +     +  +  +        +  +  +      |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 1              1     1        1  1                          1            |             
      Clear Cell Focus                     | 1              1                 2                          1            |             
      Cytoplasmic Alteration               |                   1                                                      |             
      Degeneration, Cystic                 | 1              1                                                         |             
      Degeneration                         |                   1                 1                                    |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                               1     2           3  1                     |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                | 1              1  1  1        1  1     1                    1            |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                         1              2        1              3         |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 2              2  1  1  1     1  1  1  1     2  3  2        1  2  1      |             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +           +            |             
      Fibrosis                             |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +              +  +  +  +     +  +  +  +     +  +  +        +  +  +      |             
      Atrophy                              | 1              1     1        1  1     1           1        1            |             
      Cytoplasmic Alteration               |                                                                2         |             
      Ectopic Liver                        |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 1              1     1        1  1     1           1        1            |             
      Artery, Fibrosis                     |                                                                          |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Necrotizing                     |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|             
                             DAY ON TEST   | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|             
                                           | 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.1% LM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                        +     +  +  +           +  +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +              +  +  +  +     +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +              +  +  +  +     +  +  +  +     +  +  +        +  +  +      |             
      Acanthosis                           |                                                    1                     |             
      Hyperkeratosis                       |                                                    1                     |             
      Hyperplasia, Basal Cell              |                                                    1                     |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +              +  +  +  +     +  +  +  +     +  +  +        +  +  +      |             
      Inflammation, Chronic Active         |                               1                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  | +              +  +  +  +     +  +  +  +     +  +  +        M  +  +      |             
      Hemorrhage                           |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                        +     +  +  +        +  +  +      |             
      Cardiomyopathy                       |                                        2     2  2  3           1  3      |             
      Cytomegaly                           |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                        +     +  +  +           +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                        +     +  +  +           +  +      |             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Necrosis, Coagulative                |                                                                1         |             
      Vacuolization Cytoplasmic            |                                        1     1  2              2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                        +     +  +  +           +  +      |             
      Hyperplasia                          |                                        1     1                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                        +     +  +  +           +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +              +  M  +  +     +  +  +  +     M  +  +        +  +  +      |             
      Hyperplasia                          |                                  1                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +              +  +  +  +     +  +  +  +     +  +  +        +  +  +      |             
      Autolysis                            |                                                                   2      |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Autolysis             |                                                                          |             
      Pars Distalis, Cyst                  |                   1                             2                        |             
      Pars Distalis, Hyperplasia           | 3                 2  1              2  1                       1         |             
      Pars Distalis, Necrosis              |                                                    4                     |             
      Pars Distalis, Pigmentation          |                               2  1                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|             
                             DAY ON TEST   | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|             
                                           | 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.1% LM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Angiectasis         |                               4                 3                        |             
      Pars Intermedia, Cyst                | 1                 2                          1                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                         +              +     +  +  +           +  +      |             
      Congestion                           |                         1                                                |             
      C-Cell, Hyperplasia                  |                                                                1  2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                        +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                         +        +  +  +     +  +  +        +  +  +      |             
      Abscess                              |                                     4                                    |             
      Inflammation, Chronic                |                         2        2     2     3  2  2        2  3  3      |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                                  +     +     +  +  +           +  +      |             
      Hemorrhage                           |                                  1                                       |             
      Inflammation, Acute                  |                                        2                                 |             
      Inflammation, Chronic Active         |                                  4           3     2              2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                      +              +  +     +  +  +           +  +      |             
      Atrophy                              |                      3              3                          3         |             
                                            __________________________________________________________________________|             
   Testes                                  | +              +  +  +        +     +  +     +  +  +        +  +  +      |             
      Infarct                              |                                                                          |             
      Interstitial Cell, Hyperplasia       | 1                 1  1              1  1     1  1           1     1      |             
      Seminiferous Tubule, Atrophy         | 4              4  4  4        4     3  2     2  4           4  4  1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                        +     +  +  +           +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +           +  +     +  +  +        +  +  +      |             
      Angiectasis                          |                                                                          |             
      Inguinal, Ectasia                    |                                              4                           |             
      Lumbar, Ectasia                      |                                        2     4                           |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                                          |             
      Lumbar, Inflammation, Acute          |                                        2                                 |             
      Lumbar, Pigmentation                 |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                                 2                        |             
      Mediastinal, Pigmentation            |                                                 3                        |             
      Pancreatic, Hemorrhage               |                                     1                                    |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                     2           2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|             
                             DAY ON TEST   | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|             
                                           | 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.1% LM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Pigmentation             |                                                 1                        |             
      Renal, Ectasia                       |                                        3     4                           |             
      Renal, Fibrosis                      |                                              2                           |             
      Renal, Hemorrhage                    |                                              1                           |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                              2                 1         |             
      Renal, Pigmentation                  |                                              1                 1         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                         +              +     +  +  +        +  +  +      |             
      Congestion                           |                         1                                                |             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                         +              M     +  +  +           +  +      |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                         1                    1  2  1           1         |             
      Pigmentation                         |                                              1  1  1           1         |             
                                            __________________________________________________________________________|             
   Spleen                                  |                      +  +           +  +     +  +  +           +  +      |             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |                                                    2           3  4      |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                        2        3                        |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                        +     +  M  +           M  +      |             
      Depletion Lymphoid                   |                                        3     1     2                     |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                        +     +  M  +           +  +      |             
      Abscess                              |                                                                          |             
      Galactocele                          |                                                                2         |             
      Hyperplasia                          |                                        2     2     2           2  1      |             
      Pigmentation                         |                                        1                       2         |             
                                            __________________________________________________________________________|             
   Skin                                    |                                              +  +  +        +  +  +      |             
      Cyst Epithelial Inclusion            |                                                             X            |             
      Hyperkeratosis                       |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                        +     +  +  +           +  +      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
      Hindlimb, Mineralization             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                         +              +     +  +  +           +  +      |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|             
                             DAY ON TEST   | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|             
                                           | 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.1% LM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                   +     +           +  +     +  +  +        +  +  +      |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                             1            |             
      Infiltration Cellular, Histiocyte    |                   1                          1                    1      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Mineralization               |                   1     1              1           1                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +              +  +  +  +     +  +  +  +     +  +  +        +  +  +      |             
      Foreign Body                         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Glands, Inflammation, Acute          |                   1  1        1     2                                    |             
      Lumen, Hemorrhage                    |                                                                          |             
      Lumen, Inflammation, Acute           |                                                                          |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Acute                           |                         2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                        +     +  +  +           +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Fibrosis                     |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +              +  +  +  +     +  +  +  +     +  +  +        +  +  +      |             
      Autolysis                            |                                                                          |             
      Cyst                                 |                                                             1            |             
      Hemorrhage                           |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 3              3  2  3  2     3  4  2  2     2  2  3        3  4  2      |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Necrotizing                     | 3                                                                        |             
      Interstitial Tissue, Proximal        |                                                                          |             
          Convoluted Renal Tubule,         |                                                                          |             
          Inflammation, Acute              |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Mineralization                  |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis                        |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Epithelium, Pigmentation        |                                                 2                        |             
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|             
                             DAY ON TEST   | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|             
                                           | 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.1% LM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Transitional Epithelium, Hyperplasia | 1                                1                          2  2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +              +  +  +  +     +  +  +  +     +  +  +        +  +  +      |             
      Inflammation, Chronic                |                                                                          |             
      Submucosa, Hemorrhage                |                                                                          |             
      Subserosa, Mineralization            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|             
                                           | 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1% LM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                     +  +  +           +              +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +                    +  +  +           A              +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +                    +  +  +           A              +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +                    +  +  +           A              +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +                    +  +  +           A              +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +     A     +  +     +   |             
      Necrosis, Coagulative                |                                        2                                 |             
      Epithelium, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +     +  +  +  +  +  A  +  +  +  +  +  +     A     +  +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +     +   |             
      Angiectasis                          |                               2                                          |             
      Basophilic Focus                     | 1     1  1           1     1                                1  1         |             
      Clear Cell Focus                     |                                     2                       2  3         |             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration, Cystic                 |                            2  2                                      1   |             
      Degeneration                         |                                                                          |             
      Eosinophilic Focus                   |                            1  1                             1  2         |             
      Fatty Change                         |                                  2  2     2                              |             
      Hemorrhage                           |                                     1     2                              |             
      Hepatodiaphragmatic Nodule           |                      X                                                   |             
      Hyperplasia, Focal                   |                            2                                             |             
      Inflammation, Chronic                |       1  1     1  1  1  1     1     1        1        1     1  1         |             
      Mixed Cell Focus                     |                               2                                2         |             
      Necrosis, Coagulative                |                      1           2     1                                 |             
      Thrombosis                           |                                                                      3   |             
      Bile Duct, Hyperplasia               | 2     1  1     1  1  2  1  2  1  3  1  2  1  1  3     2     2  1     3   |             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                     +              +   |             
      Fibrosis                             |                                                                          |             
      Necrosis, Coagulative                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +     +   |             
      Atrophy                              | 1     1  2     1  2  1  1  1  1     1  1  2                              |             
      Cytoplasmic Alteration               |                                                                          |             
      Ectopic Liver                        |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 1     1  1     1  1  1  1           1                       1  1         |             
      Artery, Fibrosis                     |                         3     4                                          |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Necrotizing                     |                                                             4            |             
      Duct, Dilatation                     |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|             
                                           | 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1% LM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Perivascular, Inflammation, Chronic  |                         2     2                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                            +        +  +  +           +              +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +     M  +  +  +  +  +  +  +  +  +  +  +     +     +  +     +   |             
      Acanthosis                           |                      2                    2                          1   |             
      Hyperkeratosis                       |                      2                                                   |             
      Hyperplasia, Basal Cell              |                                           2                          1   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +     +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +     M   |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +     +              +  +  +  +  +  +        +              +   |             
      Cardiomyopathy                       |          2                    2  2  2        2        1              1   |             
      Cytomegaly                           |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +     +  +  +           +              +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +     +  +  +           +              +   |             
      Angiectasis                          |                                                                          |             
      Congestion                           |                               2           1                              |             
      Hyperplasia                          |                                                                          |             
      Necrosis, Coagulative                |                                        1                                 |             
      Vacuolization Cytoplasmic            |                                     2  2                             1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +     +  +  +           +              +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                                +  +  +  +           +              +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +     M  +  +  +  +  +  +  +  +  +  +  +     M     +  +     +   |             
      Hyperplasia                          |          2                    1                                2         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     I  +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +     +   |             
      Autolysis                            |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Autolysis             |                                                       3                  |             
      Pars Distalis, Cyst                  |                      1        1                                      2   |             
      Pars Distalis, Hyperplasia           |                2  1              2  1     2  1  1              2     2   |             
      Pars Distalis, Necrosis              |                                                                          |             
      Pars Distalis, Pigmentation          |                            2                                1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|             
                                           | 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1% LM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                   1        1           1                       1     1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +                       +     +  +  +           +              +   |             
      Congestion                           |                                                                          |             
      C-Cell, Hyperplasia                  |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                           +                              |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                     +  +  +           +              +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +              +        +  +  +  M           +     +        +   |             
      Abscess                              |       4  2              4                                                |             
      Inflammation, Chronic                |          2              2        2  2                 2     2        2   |             
      Duct, Dilatation                     |                                                             4            |             
                                            __________________________________________________________________________|             
   Prostate                                | +                                   +  +  +           +              +   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 4                                   3  3  1                              |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +           +     +        +  +  +           +     +        +   |             
      Atrophy                              |          3           3                                                   |             
                                            __________________________________________________________________________|             
   Testes                                  |       +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +     +   |             
      Infarct                              |                                  4                                       |             
      Interstitial Cell, Hyperplasia       |       1        1        1  1     1  2     1  1        1     1  1     1   |             
      Seminiferous Tubule, Atrophy         |       4  4     4     4  4  4  4  4  2  1     4  4     1     3  4     3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                     +  +  +           +              +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +           +     +  +  +  +  +  +     +     +              +   |             
      Angiectasis                          |                                                                          |             
      Inguinal, Ectasia                    |                                                                          |             
      Lumbar, Ectasia                      | 2                                                                        |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       | 1                                                                        |             
      Lumbar, Inflammation, Acute          |                                                                          |             
      Lumbar, Pigmentation                 |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                  4                                       |             
      Mediastinal, Pigmentation            |       1                       1        1                                 |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|             
                                           | 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1% LM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Fibrosis                      |                                                                          |             
      Renal, Hemorrhage                    |          1                                                               |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       | 2                                                                        |             
      Renal, Pigmentation                  |          2                 1                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                      +              +  +  +           +              +   |             
      Congestion                           |                                                                          |             
      Ectasia                              |                      4                                                   |             
      Hemorrhage                           |                      1                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +  +  +           +              +   |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                     1  2              1              1   |             
      Pigmentation                         |                                     1  1              1              1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +                          +     +  +  +  +     +     +              +   |             
      Congestion                           |                                           3           3                  |             
      Depletion Lymphoid                   |                            3     3     3        3     2              2   |             
      Fibrosis                             |                            4                    2                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                  +  +  +  +           +              +   |             
      Depletion Lymphoid                   |                                  4                    3                  |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +                             +     M  +  +           M              M   |             
      Abscess                              | 4                                                                        |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          | 3                                      2  1                              |             
      Pigmentation                         |                                        1                                 |             
                                            __________________________________________________________________________|             
   Skin                                    |                                  +  +  +  +  +        +        +     +   |             
      Cyst Epithelial Inclusion            |                                                                X         |             
      Hyperkeratosis                       |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                     +  +  +           +              +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
      Hindlimb, Mineralization             |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +                             +  +  +           +              +   |             
      Hemorrhage                           |       1                                   2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|             
                                           | 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1% LM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +              +  +  +  +  +  +  +           +              +   |             
      Congestion                           |                                                       3                  |             
      Hemorrhage                           |                                  1        2                              |             
      Infiltration Cellular, Histiocyte    |          1                 1  1  1  1     1                          1   |             
      Alveolar Epithelium, Hyperplasia     |                         1                                                |             
      Artery, Mineralization               |          1                 1                                         1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +     +  +  +  +  +  +  +  +  +  +     +     +     +  +     +   |             
      Foreign Body                         |                                                                          |             
      Metaplasia, Squamous                 |                      3                                                   |             
      Glands, Inflammation, Acute          |          1                                                     1     1   |             
      Lumen, Hemorrhage                    |                                                                      3   |             
      Lumen, Inflammation, Acute           |                      2                                                   |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                     +  +  +           +              +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +        +     +                       +     +   |             
      Cornea, Fibrosis                     |                                        3                                 |             
      Cornea, Inflammation, Chronic        |                                                                          |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +     +   |             
      Autolysis                            |                                                 2                        |             
      Cyst                                 |          1                    1                 2              1         |             
      Hemorrhage                           |                               2                                          |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 4     3  4     3  2  2  2  3  4  2  1  2  2  3  3     1     4  4     2   |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Necrotizing                     |                                                                          |             
      Interstitial Tissue, Proximal        |                                                                          |             
          Convoluted Renal Tubule,         |                                                                          |             
          Inflammation, Acute              |                                                             2            |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Mineralization                  |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis                        |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Epithelium, Pigmentation        |                                        2                                 |             
      Renal Tubule, Hyperplasia, Cystic    |          2                                                               |             
      Renal Tubule, Hyperplasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|             
                                           | 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1% LM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                 1              2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +     M  +  +  +  +  +  +  +  +  +  +  +     +     +  +     +   |             
      Inflammation, Chronic                |                         1                                                |             
      Submucosa, Hemorrhage                |                                           1                              |             
      Subserosa, Mineralization            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6|              |            |
                                           | 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.1% LM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +                                                               |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +                                                               |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +                                                               |  11        |
      Parasite Metazoan                    |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +                                                               |  12        |
      Parasite Metazoan                    |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +                                                               |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  47        |
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Epithelium, Pigmentation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +     +  +  +  +  +  A  +     +  +  +  +                  |  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Angiectasis                          |                                        2                                 |      2  2.0|
      Basophilic Focus                     |                         1     1                 1  1                     |     17  1.0|
      Clear Cell Focus                     | 1              3     X                                                   |     10  1.8|
      Cytoplasmic Alteration               |                                                 2  2                     |      3  1.7|
      Degeneration, Cystic                 |                                                                          |      5  1.4|
      Degeneration                         |                                                                          |      2  1.0|
      Eosinophilic Focus                   | 2                                                                        |      5  1.4|
      Fatty Change                         |    1  1        3                       3              2                  |     12  1.9|
      Hemorrhage                           |                      1              2                                    |      4  1.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hyperplasia, Focal                   |                               3                                          |      2  2.5|
      Inflammation, Chronic                | 1  1  1              1  1     1  1           1  1  1                     |     30  1.0|
      Mixed Cell Focus                     | 2                    1                                                   |      4  1.8|
      Necrosis, Coagulative                |       2                                                                  |      8  1.6|
      Thrombosis                           |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               | 1  1  1        2     1  1  2  1  1     2     1  1  1  1                  |     48  1.5|
      Centrilobular, Necrosis, Coagulative |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   6        |
      Fibrosis                             |                                     4                                    |      1  4.0|
      Necrosis, Coagulative                |                                     4                                    |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Atrophy                              | 1                       1  2        1  1              1                  |     26  1.2|
      Cytoplasmic Alteration               |                               1                                          |      2  1.5|
      Ectopic Liver                        |                                                 X                        |      1     |
      Hyperplasia                          |    2                       2                 1                           |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6|              |            |
                                           | 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.1% LM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                | 1  1  1        1     1  1           1  1     1     1                     |     28  1.0|
      Artery, Fibrosis                     |                                  3                                       |      3  3.3|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Necrotizing                     |                                                                          |      1  4.0|
      Duct, Dilatation                     |                                                                          |      1  1.0|
      Perivascular, Inflammation, Chronic  |                                  2                                       |      3  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +     +                                                         |  14        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  49        |
      Acanthosis                           |                                                 1     1                  |      6  1.3|
      Hyperkeratosis                       |                                                 2                        |      3  1.7|
      Hyperplasia, Basal Cell              |                1     1     1           1        1     1                  |      9  1.1|
      Inflammation, Acute                  |                                     2                                    |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Necrosis, Coagulative                |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  48        |
      Hemorrhage                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                     +                                    |  18        |
      Cardiomyopathy                       |                                     3                                    |     14  2.0|
      Cytomegaly                           |                                     4                                    |      1  4.0|
      Thrombosis                           |                                     X                                    |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +     +           +     +                                       |  18        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +     +           +     +                                       |  18        |
      Angiectasis                          |                                  2                                       |      1  2.0|
      Congestion                           |                            2                                             |      3  1.7|
      Hyperplasia                          |    2           2                                                         |      2  2.0|
      Necrosis, Coagulative                |                                                                          |      2  1.0|
      Vacuolization Cytoplasmic            |    2           3           1     2                                       |     12  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +     +           +     +                                       |  18        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +                                                               |  15        |
      Hyperplasia                          | 1                                                                        |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6|              |            |
                                           | 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.1% LM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  45        |
      Hyperplasia                          |                         2              2                                 |      6  1.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  49        |
      Autolysis                            |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |                      2                                                   |      1  2.0|
      Pars Distalis, Autolysis             |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                                     1                                    |      6  1.3|
      Pars Distalis, Hyperplasia           | 2              2        1     4  2  1  2     2     1                     |     24  1.7|
      Pars Distalis, Necrosis              |                                                                          |      1  4.0|
      Pars Distalis, Pigmentation          |                1                                                         |      5  1.4|
      Pars Intermedia, Angiectasis         |                                                                          |      2  3.5|
      Pars Intermedia, Cyst                |          1                 1                                             |     10  1.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +              +                       +                        |  17        |
      Congestion                           |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +                                                               |  13        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +                                      +     +                  |  22        |
      Abscess                              |                                                 3                        |      5  3.4|
      Inflammation, Chronic                |          3                                      2     3                  |     19  2.3|
      Duct, Dilatation                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |          +                                                               |  14        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |          1                                                               |      9  2.6|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +  +     +                    +        +                           |  22        |
      Atrophy                              |       3        3                    3        2                           |      9  2.9|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  46        |
      Infarct                              |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       | 1     1  2     1     1  1  1  1  1  1        1  1  1  1                  |     35  1.1|
      Seminiferous Tubule, Atrophy         | 4  4  4  2     4     3  3  4  3  4  3  3     4  4  4  4                  |     44  3.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +                                                               |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  95                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6|              |            |
                                           | 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.1% LM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +     +           +        +           +     +                  |  29        |
      Angiectasis                          |                                     1                                    |      1  1.0|
      Inguinal, Ectasia                    |                                                                          |      1  4.0|
      Lumbar, Ectasia                      |                                                                          |      3  2.7|
      Lumbar, Hemorrhage                   |       3                                                                  |      1  3.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |                                                                          |      1  1.0|
      Lumbar, Inflammation, Acute          |                                                                          |      1  2.0|
      Lumbar, Pigmentation                 |       2                                                                  |      1  2.0|
      Mediastinal, Ectasia                 |                1           3                                             |      2  2.0|
      Mediastinal, Hemorrhage              |          1                          2                                    |      4  2.3|
      Mediastinal, Pigmentation            |                                                 1                        |      5  1.4|
      Pancreatic, Hemorrhage               |                                     2                                    |      2  1.5|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                2                    2                                    |      5  2.0|
      Pancreatic, Pigmentation             |                1                                                         |      2  1.0|
      Renal, Ectasia                       |                                                                          |      2  3.5|
      Renal, Fibrosis                      |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |       3        2                                                         |      4  1.8|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                2                                                         |      4  1.8|
      Renal, Pigmentation                  |       2        2                                                         |      6  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +     +                    +                 +                  |  18        |
      Congestion                           |                                                                          |      1  1.0|
      Ectasia                              |                                                                          |      1  4.0|
      Hemorrhage                           |                1                    3                                    |      4  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +     +                                      +                  |  14        |
      Hemorrhage                           |                1                                                         |      1  1.0|
      Infiltration Cellular, Histiocyte    |          1                                                               |     10  1.2|
      Pigmentation                         |          1                                                               |      9  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +     +        +  +  +        +              +                  |  25        |
      Congestion                           |                                                                          |      2  3.0|
      Depletion Lymphoid                   |          4     3              1        3              4                  |     14  2.9|
      Fibrosis                             |                3              2                       1                  |      5  2.4|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       M  +                                                               |  11        |
      Depletion Lymphoid                   |                                                                          |      5  2.6|
      Hemorrhage                           |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6|              |            |
                                           | 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.1% LM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +                                                               |  10        |
      Abscess                              |                                                                          |      1  4.0|
      Galactocele                          |                                                                          |      1  2.0|
      Hyperplasia                          |          1                                                               |      9  1.8|
      Pigmentation                         |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +                 +     +                                       |  18        |
      Cyst Epithelial Inclusion            |       X                                                                  |      3     |
      Hyperkeratosis                       |                                  3                                       |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +                                                               |  12        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Hindlimb, Mineralization             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +                                                               |  15        |
      Hemorrhage                           |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +     +     +              +  +     +  +     +                  |  28        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |          2     1                                      1                  |      6  1.3|
      Infiltration Cellular, Histiocyte    |          1     1     1              1  1     1  1     1                  |     18  1.0|
      Alveolar Epithelium, Hyperplasia     |                2     1                                1                  |      4  1.3|
      Artery, Mineralization               |          1                          1  1     1  1     1                  |     13  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +     +  +  +  +  +  +  +        +  +  +                  |  48        |
      Foreign Body                         |                               1                                          |      1  1.0|
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
      Glands, Inflammation, Acute          |                         1  1     1                 1                     |     11  1.1|
      Lumen, Hemorrhage                    |                                                                          |      1  3.0|
      Lumen, Inflammation, Acute           |                               1                 1                        |      3  1.3|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +                                                               |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6|              |            |
                                           | 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.1% LM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +  +                    +        +              I                  |   9        |
      Cornea, Fibrosis                     |                                                                          |      1  3.0|
      Cornea, Inflammation, Chronic        |          2                                                               |      1  2.0|
      Sclera, Metaplasia, Osseous          |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Autolysis                            |                                     2                                    |      2  2.0|
      Cyst                                 |                         2                                                |      6  1.3|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydronephrosis                       | 2                                                                        |      1  2.0|
      Nephropathy                          | 4  3  3  2     3     3  4  2  3  2  3  2     2  3  3  3                  |     50  2.7|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Necrotizing                     |                                                                          |      1  3.0|
      Interstitial Tissue, Proximal        |                                                                          |            |
          Convoluted Renal Tubule,         |                                                                          |            |
          Inflammation, Acute              |                                                                          |      1  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Mineralization                  |       1                                                                  |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis                        |       2                                                                  |      1  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Epithelium, Pigmentation        |                                                                          |      2  2.0|
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                       2                  |      1  2.0|
      Transitional Epithelium, Hyperplasia |                      1              1           2                        |      9  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +     +  +  +  +  +  +  +     +  +  +  +                  |  49        |
      Inflammation, Chronic                |                         1                                                |      2  1.0|
      Submucosa, Hemorrhage                |                                                                          |      1  1.0|
      Subserosa, Mineralization            |    1                                                                     |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|             
                             DAY ON TEST   | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|             
                                           | 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0% MM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +        M                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +        +                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +        +                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +        +                                                         |             
      Parasite Metazoan                    |       1                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +        +                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +              +  +  +        +  +  +  +        +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +              +  +  +        +  +  +  +        +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  +  +        +              +  +  +        +  +  +  +        +     +  +|             
      Epithelium, Pigmentation             |    1  1                             2           1  2           1     1   |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +              +  +  +        +  +  +  +        +     +  +|             
      Autolysis                            | 3                                                                        |             
      Epithelium, Pigmentation             |       2                                                                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +              +  +  +        +  +  +  +        +     +  +|             
      Angiectasis                          | 1                                                                        |             
      Basophilic Focus                     | 2                             1                    1           1     1  1|             
      Clear Cell Focus                     |       1                       1     1                          1         |             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration, Cystic                 | 2                                                                    1   |             
      Degeneration                         |                                                                          |             
      Eosinophilic Focus                   | 2                                                              1     3   |             
      Fatty Change                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                | 1  1  1                          1  1           1              1         |             
      Mixed Cell Focus                     |                               2                                          |             
      Mixed Cell Focus, Multiple           |                                                                          |             
      Necrosis, Coagulative                |       1                          1           1                 1         |             
      Thrombosis                           |                                                       X                  |             
      Bile Duct, Hyperplasia               | 1  1  1        3              1  2  1        3  1  1  2        1     2  1|             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +                  |             
      Fibrosis                             |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +              +  +  +        +  +  +  +        +     +  +|             
      Atrophy                              | 2                                1  1        1                       2  1|             
      Cyst                                 |                4                                                         |             
      Fibrosis                             |    2                             2                                       |             
      Hyperplasia                          |                                                                1        2|             
      Inflammation, Chronic                | 2     1                          2  1        1                       3  2|             
      Necrosis, Coagulative                |                                                                      3   |             
      Pigmentation                         |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|             
                             DAY ON TEST   | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|             
                                           | 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0% MM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                2                                                         |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Necrotizing                     |    4                                                                     |             
      Serosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +        +                                                         |             
      Parotid Gland, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +              +  +  +        +  +  +  +        +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +              +  +  +        +  +  +  +        +     +  +|             
      Acanthosis                           |                                                                         2|             
      Hyperkeratosis                       |                                                                         2|             
      Hyperplasia, Basal Cell              |    1                                1                                   2|             
      Mineralization                       |    1                                                                     |             
      Ulcer                                |                                                                          |             
      Muscularis, Pigmentation             |                                                       1                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +              +  +  +        +  +  +  +        +     +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Epithelium, Pigmentation             |                                                                          |             
      Mucosa, Mineralization               |    3                             4                                       |             
      Muscularis, Mineralization           |    3                                                                     |             
                                            __________________________________________________________________________|             
   Tongue                                  | +  +  +        +              +  +  +        +  +  +  +        +     +  +|             
      Artery, Mineralization               |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                                                                     |             
      Aorta, Mineralization                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Heart                                   |       +        +                                                        +|             
      Cardiomyopathy                       |       2        2                                                        3|             
      Metaplasia, Osseous                  |                                                                         1|             
      Thrombosis                           |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +        +                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +        +                                                         |             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            |                1                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +        +                                                         |             
      Hyperplasia                          |                1                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +        +                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M        M              +  +  +        +  +  +  +        +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|             
                             DAY ON TEST   | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|             
                                           | 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0% MM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |    3                             1                             1        3|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +              +  +  +        +  +  +  +        +     +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Autolysis             |                                                                          |             
      Pars Distalis, Congestion            |                                                                          |             
      Pars Distalis, Cyst                  |                2                                                         |             
      Pars Distalis, Hyperplasia           |                1                    2              1  1        1     1  3|             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Crystals            |                                                                          |             
      Pars Intermedia, Cyst                |                1                                1                    1   |             
      Pars Intermedia, Ectopic Tissue      |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
      Pars Nervosa, Ectopic Tissue         |                                                                          |             
      Pars Nervosa, Hyperplasia            |                                                                          |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +        +                    +                          +         |             
      C-Cell, Hyperplasia                  |    1                                1                                    |             
      Follicle, Pigmentation               |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +        +                                      +                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +        +              +                                +         |             
      Abscess                              |                                                                3         |             
      Inflammation, Chronic                |       3        2                                               2         |             
                                            __________________________________________________________________________|             
   Prostate                                |       +        +                                                         |             
      Inflammation, Chronic Active         |       1                                                                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +        +                 +           +  +                    +   |             
      Atrophy                              | 3                                2           1  2                    3   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +        +              +  +  +        +  +  +  +        +     +  +|             
      Interstitial Cell, Hyperplasia       | 1  2  2        2              1     1        1     2           1     1  1|             
      Seminiferous Tubule, Atrophy         |    2  3        2              4  4  3        4  4  4           4     4  4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +        +                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +                                      +        +     +  +|             
      Artery, Pancreatic, Thrombosis       |                                                                          |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|             
                             DAY ON TEST   | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|             
                                           | 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0% MM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Ectasia                 |                                                                2         |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                1                                                         |             
      Mediastinal, Pigmentation            |                1                                                         |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                       1                  |             
      Pancreatic, Pigmentation             |                                                       2                  |             
      Renal, Ectasia                       |    3                                                                     |             
      Renal, Hemorrhage                    | 3  4                                                                     |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       | 2                                                                        |             
      Renal, Pigmentation                  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +        +                                                         |             
      Ectasia                              |       2                                                                  |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +                                                     +   |             
      Ectasia                              |                                                                      2   |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2  1        1                                                     1   |             
      Pigmentation                         |       1        1                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +              +  +           +  +  +  +        +     +   |             
      Congestion                           |                                  4                                       |             
      Depletion Lymphoid                   |    2           2                             2        3                  |             
      Fibrosis                             |                                  3           3     3           2         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                               1                                          |             
      Pigmentation                         |                                                                          |             
      Thrombosis                           |                                  4                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +        +                                                         |             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +        +                                                         |             
      Hyperplasia                          |       1        2                                                         |             
      Pigmentation                         |       1        1                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    |       +        +                    +                 +                 +|             
      Acanthosis                           |                                                                          |             
      Fibrosis                             |                                                       2                  |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|             
                             DAY ON TEST   | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|             
                                           | 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0% MM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +        +                                               +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +        +                                                         |             
      Cerebrum, Degeneration, Focal        |                2                                                         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +              +                       +              +   |             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |    1                          1                       1                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    2                                                                     |             
      Artery, Mineralization               | 1  1                                                                     |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +              +  +  +        +  +  +  +        +     +   |             
      Metaplasia, Squamous                 |                                                                          |             
      Glands, Inflammation, Acute          | 1                                                              1         |             
      Lumen, Inflammation, Acute           |                                     1                                    |             
      Mucosa, Congestion                   |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +        +                                                         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +  +                       +  I                                       |             
      Artery, Mineralization               |    1                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +              +  +  +        +  +  +  +        +     +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 3  4  2        3              3  4  2        3  2  2  2        4     2  4|             
      Collecting Tubule, Mineralization    |    3                                                                     |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|             
                             DAY ON TEST   | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|             
                                           | 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0% MM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Mineralization                  |    3                             3                                       |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Epithelium, Pigmentation        |                                                                          |             
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia | 2  1                                                           2        2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +              +  +  +        +  +  +  +        +     +  +|             
      Inflammation, Chronic                |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Subserosa, Mineralization            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|             
                                           | 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0% MM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                        +  +              +           +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +                                +  A              +           +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +                                +  A              +           +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                        +  A              +           +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                        +  A              +           +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +     +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +     +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +     +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +  +   |             
      Epithelium, Pigmentation             |          2                    2  1           1                           |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    M  +  +     M  +  +        M  +  +  +  A  M  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                                          |             
      Epithelium, Pigmentation             |          1                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                        2                                 |             
      Basophilic Focus                     |       2  1                       1                 1        1     1      |             
      Clear Cell Focus                     |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration, Cystic                 |       1        1              1                                1  1      |             
      Degeneration                         |                                                             1            |             
      Eosinophilic Focus                   |                                                             1  1  1      |             
      Fatty Change                         |                   1                                   3  3               |             
      Hemorrhage                           |                               3                    3                     |             
      Inflammation, Chronic                |    1           1  1  1        1           1     1  1        1     1      |             
      Mixed Cell Focus                     |                   1                                            3         |             
      Mixed Cell Focus, Multiple           |                                                                          |             
      Necrosis, Coagulative                |    2           2                    2              3                     |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |       2  1     1  1  1        1  1  1  1  1  2  1  1  3     1  2  1  1   |             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +           +                                                      |             
      Fibrosis                             |                   2                                                      |             
      Mineralization                       |                   1                                                      |             
      Necrosis, Coagulative                |                   3                                                      |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Atrophy                              |       2  1        1           2           1     2     1  1  1  1  1      |             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                               2                                          |             
      Inflammation, Chronic                |    2  1  1        1           1           1  1  1  1  1  1  1  1  1      |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|             
                                           | 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0% MM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Necrotizing                     |                4                                                         |             
      Serosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                        +  +              +           +   |             
      Parotid Gland, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                          3               |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |       2        1                                   1     1               |             
      Mineralization                       |                                  2                                       |             
      Ulcer                                |                                                                          |             
      Muscularis, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |                                                          1               |             
      Necrosis, Coagulative                |                                                          1               |             
      Epithelium, Pigmentation             |                                                    1                     |             
      Mucosa, Mineralization               |                                                                          |             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |    +  M  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Artery, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +                                +  +        +     +           +   |             
      Cardiomyopathy                       |       3                                2  3        3     2           2   |             
      Metaplasia, Osseous                  |                                                                          |             
      Thrombosis                           |       4                                4           4                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +     +                    +  +  +        +     +           +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +     +                    +  +  +        +     +           +   |             
      Angiectasis                          |    2                                                     2               |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Necrosis, Coagulative                |                                     1                                    |             
      Vacuolization Cytoplasmic            |                                     2  1                 3           2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +     +                    +  +  +        +     +           +   |             
      Hyperplasia                          |                                        1                 1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                        +  +              +        +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  +     +  +  +        M  +  +  +  +  +  +  +  +  +  +  +  +  I   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|             
                                           | 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0% MM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Angiectasis           |                                                       3                  |             
      Pars Distalis, Autolysis             |                                           3                              |             
      Pars Distalis, Congestion            |                                                          2               |             
      Pars Distalis, Cyst                  |                                                                   2      |             
      Pars Distalis, Hyperplasia           |    2  2        2  2                                   3     1            |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Angiectasis         |                                              3     3                     |             
      Pars Intermedia, Crystals            |                                                       4                  |             
      Pars Intermedia, Cyst                |          1        1              3  1                 3           3  1   |             
      Pars Intermedia, Ectopic Tissue      |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
      Pars Nervosa, Ectopic Tissue         |                                                                          |             
      Pars Nervosa, Hyperplasia            |                                                                   2      |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +                       +  +  +  +              +           +   |             
      C-Cell, Hyperplasia                  |          1                                                               |             
      Follicle, Pigmentation               |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                        +  +              +           +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                       +     +  +              +           +   |             
      Abscess                              |                                  4                                       |             
      Inflammation, Chronic                |                                        2  2              2           2   |             
                                            __________________________________________________________________________|             
   Prostate                                |                                        +  +              +           +   |             
      Inflammation, Chronic Active         |                                        4  1              2           1   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                      +                 +  +              +        +  +   |             
      Atrophy                              |                      2                                            3      |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +     +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Interstitial Cell, Hyperplasia       |    2  1  1     1  1  1        1     1  2  1  1     1  1  1     1     1   |             
      Seminiferous Tubule, Atrophy         |    3  3  4     4  4  4           4  4     2  4     4  4  3  4  4  4  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                        +  +              +           +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +                       +        +  +  +           +  +        +   |             
      Artery, Pancreatic, Thrombosis       |                               2                                          |             
      Lumbar, Hemorrhage                   |                                        1                                 |             
      Lumbar, Hyperplasia, Plasma Cell     |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|             
                                           | 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0% MM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Ectasia                 |                                        2                                 |             
      Mediastinal, Hemorrhage              |                                        2                 3               |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hemorrhage               |                               2                          2               |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                        2                                 |             
      Pancreatic, Pigmentation             |                               1        1                                 |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hemorrhage                    |    2                                   2                                 |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +                                +  +  +           +           +   |             
      Ectasia                              |                                              4                           |             
      Hemorrhage                           |                                        2     2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +                       +        +  +              +           +   |             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                               1        2                 2               |             
      Infiltration Cellular, Histiocyte    |                               1        1  1              1           2   |             
      Pigmentation                         |                                        1  1              1           2   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +     +     +           +  +  +  +  +  +  +  +  +     +  +  +   |             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |       3        2                    3     2                          3   |             
      Fibrosis                             |                4                 1           3                 2         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                                   3      |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +                                +  +              +           +   |             
      Congestion                           |                                           3                              |             
      Depletion Lymphoid                   |                                        3                 3           3   |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                        +  +              +  +  +  +  +   |             
      Hyperplasia                          |                                        2  2              1           2   |             
      Pigmentation                         |                                        1                                 |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +                    +        +  +              +           +   |             
      Acanthosis                           |    3                                                                     |             
      Fibrosis                             |                                                                          |             
      Hyperkeratosis                       |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|             
                                           | 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0% MM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                        +  +              +           +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                        +  +              +           +   |             
      Cerebrum, Degeneration, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                 +                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +                       +  +     +  +           +  +  +  +  +  +   |             
      Congestion                           |                                           4                              |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                       1  2  1        1   |             
      Infiltration Cellular, Histiocyte    |    1  1                       1        2  1           1  1  1     1  1   |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |                                        1                                 |             
      Alveolar Epithelium, Hyperplasia     |                               1                                          |             
      Artery, Mineralization               |       1                          1     1              1  1           1   |             
      Bronchiole, Epithelium, Hyperplasia  |                                                       1                  |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Metaplasia, Squamous                 |          1                       2                                       |             
      Glands, Inflammation, Acute          |                               1                                          |             
      Lumen, Inflammation, Acute           |          1        2              2        4  1                           |             
      Mucosa, Congestion                   |                                           4                              |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                        +  +              +           +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +           +                        |             
                                            __________________________________________________________________________|             
   Eye                                     |       I        I                                                         |             
      Artery, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          |    4  4  3     4  4  2        3  3  3  3  2  3  3  4  3  3  3  2  3  2   |             
      Collecting Tubule, Mineralization    |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 109                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|             
                                           | 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0% MM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Mineralization                  |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Epithelium, Pigmentation        |                                                                          |             
      Renal Tubule, Hyperplasia, Cystic    |                1                                                         |             
      Renal Tubule, Hyperplasia            |    1                                                                     |             
      Transitional Epithelium, Hyperplasia |    1  1  2     2  1           1        2                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                   1      |             
      Artery, Mineralization               |                                                                          |             
      Subserosa, Mineralization            |                               1                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 110                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1|              |            |
                             DAY ON TEST   | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9|              |            |
                                           | 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    1.0% MM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +              +           +  +     +  +                     |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +     +              +           +  +     +  +                     |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +     +              +           +  +     +  +                     |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +              +           +  +     +  +                     |  11        |
      Parasite Metazoan                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +              +           +  +     +  M                     |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +                     |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +     +  +  M  +  +                     |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +                     |  48        |
      Epithelium, Pigmentation             | 2                 1           2              2                           |     15  1.5|
      Peyer's Patch, Hyperplasia           |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | M  +  M     +  +  +  +  +  +  +  +     +  +  +  +  +                     |  43        |
      Autolysis                            |                                                                          |      1  3.0|
      Epithelium, Pigmentation             |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +                     |  50        |
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     | 1  1              1           1              1  1                        |     18  1.1|
      Clear Cell Focus                     |                1                                                         |      5  1.0|
      Cytoplasmic Alteration               |                      2                                                   |      1  2.0|
      Degeneration, Cystic                 |                1  1                                                      |      9  1.1|
      Degeneration                         |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                1                                                         |      7  1.4|
      Fatty Change                         |                                           1     1                        |      5  1.8|
      Hemorrhage                           |                                  2                                       |      3  2.7|
      Inflammation, Chronic                |    1  1     1  1  2     1  1  1  1                                       |     26  1.0|
      Mixed Cell Focus                     |    1                                                                     |      4  1.8|
      Mixed Cell Focus, Multiple           | 3                                                                        |      1  3.0|
      Necrosis, Coagulative                | 1                                                                        |      9  1.6|
      Thrombosis                           |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 2  1  1     1  2     1  1  1  1  1     2  2  2  1  2                     |     47  1.4|
      Centrilobular, Necrosis, Coagulative |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                    +                        |   5        |
      Fibrosis                             |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +                     |  50        |
      Atrophy                              |    1        1  2           2  1  2                                       |     23  1.3|
      Cyst                                 |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 111                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1|              |            |
                             DAY ON TEST   | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9|              |            |
                                           | 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    1.0% MM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      2  2.0|
      Hyperplasia                          |                                                                          |      3  1.7|
      Inflammation, Chronic                |    1           1  1  1  1  1  1  1        1                              |     30  1.2|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      2  1.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Necrotizing                     |                                                                          |      2  4.0|
      Serosa, Hyperplasia                  |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +              +           +  +     +  +                     |  12        |
      Parotid Gland, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +                     |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +     +  +     +  +  +  +  +                     |  49        |
      Acanthosis                           |                                              3                           |      2  2.5|
      Hyperkeratosis                       |                                              3                           |      2  2.5|
      Hyperplasia, Basal Cell              |                                              2                           |      8  1.4|
      Mineralization                       |                   1                                                      |      3  1.3|
      Ulcer                                |                                              4                           |      1  4.0|
      Muscularis, Pigmentation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +     +  +     +  +  +  +  +                     |  49        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
      Epithelium, Pigmentation             |                1              1                                          |      3  1.0|
      Mucosa, Mineralization               |                                              2                           |      3  3.0|
      Muscularis, Mineralization           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  | +  +  +     +  +  +  +  +  +  M  +     M  +  +  +  +                     |  47        |
      Artery, Mineralization               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +           +     +        +           +  +     +  +                     |  18        |
      Cardiomyopathy                       | 2           2              2           2        2  3                     |     15  2.3|
      Metaplasia, Osseous                  | 2                                                                        |      2  1.5|
      Thrombosis                           |                                        2                                 |      5  3.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +        +              +     +     +  +     +  +                     |  21        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 112                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1|              |            |
                             DAY ON TEST   | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9|              |            |
                                           | 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    1.0% MM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +        +              +     +     +  +     +  +                     |  21        |
      Angiectasis                          |                                                                          |      2  2.0|
      Hemorrhage                           |             4                                                            |      1  4.0|
      Hyperplasia                          | 1                                                                        |      1  1.0|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                        1        2  2                     |      8  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +        +              +     +     +  +     +  +                     |  21        |
      Hyperplasia                          |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +              +           +  +     +  +                     |  13        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     I  +  +  +  +  M  +  +     +  +  +  +  +                     |  43        |
      Hyperplasia                          |                      2                       3                           |      6  2.2|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +                     |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Autolysis             |             2                                                            |      2  2.5|
      Pars Distalis, Congestion            |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                        2  2                              |      4  2.0|
      Pars Distalis, Hyperplasia           |                      1        2           2     2                        |     17  1.7|
      Pars Distalis, Pigmentation          |                                  1                                       |      1  1.0|
      Pars Intermedia, Angiectasis         |                               2                                          |      3  2.7|
      Pars Intermedia, Crystals            |                                                                          |      1  4.0|
      Pars Intermedia, Cyst                |                                  2     2  1  1                           |     14  1.6|
      Pars Intermedia, Ectopic Tissue      |                            2                                             |      1  2.0|
      Pars Intermedia, Hyperplasia         |                               1                                          |      1  1.0|
      Pars Nervosa, Ectopic Tissue         |                            2                                             |      1  2.0|
      Pars Nervosa, Hyperplasia            |                                                                          |      1  2.0|
      Rathke's Cleft, Cyst                 |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +     +  +  +        +           +  +  +  +  +                     |  22        |
      C-Cell, Hyperplasia                  |                2  1                          2                           |      6  1.3|
      Follicle, Pigmentation               |                                           1                              |      1  1.0|
      Follicular Cell, Hyperplasia         |                                        1                                 |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |             +                                +                           |   2        |
                                            __________________________________________________________________________|____________|
   Epididymis                              |             +              +           +  +     +  +                     |  13        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +     +              +  +        +  +     +  +                     |  19        |
      Abscess                              |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 113                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN                                         Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 14:51:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1|              |            |
                             DAY ON TEST   | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9|              |            |
                                           | 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    1.0% MM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |       1     1              1           2        2  2                     |     13  1.8|
                                            __________________________________________________________________________|____________|
   Prostate                                |             +              +           +  +     +  +                     |  12        |
      Inflammation, Chronic Active         |             1              2           3  3        1                     |     10  1.9|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +     +     +  +     +           +  +     +  +                     |  23        |
      Atrophy                              | 3                    3                                                   |      9  2.4|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +     +  +     +  +  +  +  +     +  +  +  +  +                     |  48        |
      Interstitial Cell, Hyperplasia       | 1  1  1     1  1     1  1  1  1  1     1  1  1     1                     |     41  1.1|
      Seminiferous Tubule, Atrophy         | 4  4  3        4     4  3  4  4  4     2  3  4  3  1                     |     43  3.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +              +           +  +     +  +                     |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +     +              +  +        +  +     +  +                     |  26        |
      Artery, Pancreatic, Thrombosis       |                                                                          |      1  2.0|
      Lumbar, Hemorrhage                   |                                                                          |      1  1.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  4.0|
      Mediastinal, Ectasia                 | 2                                                                        |      3  2.0|
      Mediastinal, Hemorrhage              |             2                                                            |      3  2.3|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Mediastinal, Pigmentation            |                            1                                             |      2  1.0|
      Pancreatic, Hemorrhage               |                                                                          |      2  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      2  1.5|
      Pancreatic, Pigmentation             |                                                                          |      3  1.3|
      Renal, Ectasia                       | 2                                                                        |      2  2.5|
      Renal, Hemorrhage                    |       2                                                                  |      5  2.6|
      Renal, Hyperplasia, Lymphoid         |       3                                                                  |      1  3.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                           1                              |      2  1.5|
      Renal, Pigmentation                  | 2                                         1                              |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +              +  +        +  +     +  +                     |  15        |
      Ectasia                              |                               4                                          |      3  3.3|
      Hemorrhage                           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +              +           +  +     +  +                     |  17        |
      Ectasia                              |                                                                          |      1  2.0|
      Hemorrhage                           |                            2                                             |      4  1.8|
      Infiltration Cellular, Histiocyte    |                            2           1  1     1                        |     14  1.3|
      Pigmentation                         |                            1           1  1     1                        |     10  1.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +     +        +           +  +  +  +  +                     |  38        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 114                                                               
NTP Experiment-Test: 05033-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             QUERCETIN