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TDMS Study 05037-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                PENTACHLOROANISOLE                                  DATE: 09/05/94       
EXPERIMENT: 05037 TEST: 04                                                                                     TIME: 06:24:43       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NOI-ES-28024          ROUTE: GAVAGE                                                                      NTP C#: 56520        
PATHOLOGIST: T. MAKOVEC                      S. EUSTIS                                                         CAS: 1825-21-4       
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Southern Research Inst                                PENTACHLOROANISOLE                                  DATE: 09/05/94      
EXPERIMENT: 05037 TEST: 04                                                                                     TIME: 06:24:43      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NOI-ES-28024          ROUTE: GAVAGE                                                                      NTP C#: 56520       
PATHOLOGIST: T. MAKOVEC                      S. EUSTIS                                                         CAS: 1825-21-4      
 
 
 
 
 
                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                PENTACHLOROANISOLE                                  DATE: 09/05/94       
EXPERIMENT: 05037 TEST: 04                                                                                     TIME: 06:24:43       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NOI-ES-28024          ROUTE: GAVAGE                                                                      NTP C#: 56520        
PATHOLOGIST: T. MAKOVEC                      S. EUSTIS                                                         CAS: 1825-21-4       
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                       IN THE ANALYSIS OF THE STUDY OF PENTACHLOROANISOLE
 
              ====================================================================================================
 
                                                           MALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma Benign
                             Liver                         Hemangiosarcoma
                             Lung                          Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
                             All Organs                    Hemangiosarcoma
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
 
                                                           FEMALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             All Organs                    Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
                                                            NOS, or Undifferentiated Cell Type
                                                           Malignant Tumors
 
              ====================================================================================================
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE   1
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Gland: Non-medullary, Non-cortical                                                                                       |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       0/50 (0%)       2/49 (4%)      |     0/50 (0%)       0/50 (0%)       0/49 (0%)      |
|ADJUSTED (b)           |     11.5%            0.0%            6.9%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     2/30 (7%)       0/27 (0%)       1/27 (4%)      |     0/24 (0%)       0/25 (0%)       0/15 (0%)      |
|FIRST INCIDENCE (DAYS) |      589             ---             715           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.245N        P=0.069N        P=0.370N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.185N        P=0.084N        P=0.303N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.226N        P=0.063N        P=0.344N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.228N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.059N        P=0.349N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       4/50 (8%)       7/48 (15%)     |     0/50 (0%)       1/49 (2%)       0/48 (0%)      |
|ADJUSTED (b)           |      0.0%           11.4%           23.3%          |      0.0%            2.9%            0.0%          |
|TERMINAL (d)           |     0/30 (0%)       1/27 (4%)       5/27 (19%)     |     0/24 (0%)       0/25 (0%)       0/15 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             691             691           |      ---             564             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.005 **      P=0.067         P=0.007 **     |     P=0.707         P=0.484           (e)          |
|INCIDENTAL TUMOR       |     P=0.003 **      P=0.125         P=0.007 **     |     P=0.726         P=0.473           (e)          |
|LOGISTIC REGRESSION    |     P=0.004 **      P=0.069         P=0.007 **     |     P=0.730         P=0.499           (e)          |
|COCHRAN-ARMITAGE       |     P=0.005 **                                     |     P=0.725                                        |
|FISHER EXACT           |                     P=0.059         P=0.005 **     |                     P=0.495           (e)          |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE   2
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            6.6%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/30 (0%)       1/27 (4%)       0/28 (0%)      |     0/24 (0%)       0/25 (0%)       0/16 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             715             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.657         P=0.235           (e)          |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.668         P=0.292           (e)          |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.662         P=0.253           (e)          |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.669                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.247           (e)          |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       0/23 (0%)       1/50 (2%)      |     2/50 (4%)       0/25 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |      3.0%            0.0%            3.6%          |      8.3%            0.0%            6.3%          |
|TERMINAL (d)           |     0/30 (0%)       0/0             1/28 (4%)      |     2/24 (8%)       0/0             1/16 (6%)      |
|FIRST INCIDENCE (DAYS) |      710             ---             729 (T)       |      729 (T)         ---             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.633         P=0.494N        P=0.742        |     P=0.524N          (e)           P=0.642N       |
|INCIDENTAL TUMOR       |     P=0.647         P=0.379N        P=0.753        |     P=0.524N          (e)           P=0.642N       |
|LOGISTIC REGRESSION    |     P=0.640         P=0.669N        P=0.755        |     P=0.524N          (e)           P=0.642N       |
|COCHRAN-ARMITAGE       |     P=0.654                                        |     P=0.372N                                       |
|FISHER EXACT           |                     P=0.685N        P=0.753N       |                     P=0.441N        P=0.500N       |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE   3
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       6/50 (12%)      4/50 (8%)      |     3/50 (6%)       0/50 (0%)       4/50 (8%)      |
|ADJUSTED (b)           |      6.1%           19.4%           13.2%          |     10.7%            0.0%           20.9%          |
|TERMINAL (d)           |     1/30 (3%)       4/27 (15%)      3/28 (11%)     |     2/24 (8%)       0/25 (0%)       3/16 (19%)     |
|FIRST INCIDENCE (DAYS) |      705             701             701           |      576             ---             499           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.264         P=0.126         P=0.312        |     P=0.276         P=0.124N        P=0.325        |
|INCIDENTAL TUMOR       |     P=0.261         P=0.188         P=0.317        |     P=0.315         P=0.125N        P=0.372        |
|LOGISTIC REGRESSION    |     P=0.264         P=0.160         P=0.318        |     P=0.355         P=0.126N        P=0.432        |
|COCHRAN-ARMITAGE       |     P=0.290                                        |     P=0.406                                        |
|FISHER EXACT           |                     P=0.134         P=0.339        |                     P=0.121N        P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      0.0%            6.7%            0.0%          |
|TERMINAL (d)           |     0/30 (0%)       0/27 (0%)       0/28 (0%)      |     0/24 (0%)       0/25 (0%)       0/16 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      ---             598             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.617         P=0.223           (e)          |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.619N        P=0.190           (e)          |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.660         P=0.235           (e)          |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.669                                        |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.247           (e)          |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE   4
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       6/50 (12%)      4/50 (8%)      |     3/50 (6%)       2/50 (4%)       4/50 (8%)      |
|ADJUSTED (b)           |      6.1%           19.4%           13.2%          |     10.7%            6.7%           20.9%          |
|TERMINAL (d)           |     1/30 (3%)       4/27 (15%)      3/28 (11%)     |     2/24 (8%)       0/25 (0%)       3/16 (19%)     |
|FIRST INCIDENCE (DAYS) |      705             701             701           |      576             598             499           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.264         P=0.126         P=0.312        |     P=0.279         P=0.516N        P=0.325        |
|INCIDENTAL TUMOR       |     P=0.261         P=0.188         P=0.317        |     P=0.360         P=0.547N        P=0.372        |
|LOGISTIC REGRESSION    |     P=0.264         P=0.160         P=0.318        |     P=0.366         P=0.512N        P=0.432        |
|COCHRAN-ARMITAGE       |     P=0.290                                        |     P=0.417                                        |
|FISHER EXACT           |                     P=0.134         P=0.339        |                     P=0.500N        P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       8/50 (16%)     10/50 (20%)     |     0/50 (0%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |      5.7%           20.0%           29.9%          |      0.0%            0.0%            6.3%          |
|TERMINAL (d)           |     0/30 (0%)       1/27 (4%)       6/28 (21%)     |     0/24 (0%)       0/25 (0%)       1/16 (6%)      |
|FIRST INCIDENCE (DAYS) |      701             682             612           |      ---             ---             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.014 *       P=0.069         P=0.015 *      |     P=0.211           (e)           P=0.419        |
|INCIDENTAL TUMOR       |     P=0.010 *       P=0.185         P=0.017 *      |     P=0.211           (e)           P=0.419        |
|LOGISTIC REGRESSION    |     P=0.008 **      P=0.051         P=0.015 *      |     P=0.211           (e)           P=0.419        |
|COCHRAN-ARMITAGE       |     P=0.014 *                                      |     P=0.269                                        |
|FISHER EXACT           |                     P=0.046 *       P=0.014 *      |                       (e)           P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE   5
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    20/50 (40%)     24/50 (48%)     14/50 (28%)     |     8/50 (16%)      8/50 (16%)     12/50 (24%)     |
|ADJUSTED (b)           |     51.5%           65.6%           44.2%          |     28.2%           29.7%           53.4%          |
|TERMINAL (d)           |    12/30 (40%)     15/27 (56%)     11/28 (39%)     |     5/24 (21%)      7/25 (28%)      7/16 (44%)     |
|FIRST INCIDENCE (DAYS) |      424             651             596           |      477             438             381           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.207N        P=0.244         P=0.213N       |     P=0.046 *       P=0.591N        P=0.065        |
|INCIDENTAL TUMOR       |     P=0.154N        P=0.368         P=0.170N       |     P=0.100         P=0.600         P=0.140        |
|LOGISTIC REGRESSION    |     P=0.126N        P=0.356         P=0.142N       |     P=0.097         P=0.569         P=0.124        |
|COCHRAN-ARMITAGE       |     P=0.129N                                       |     P=0.185                                        |
|FISHER EXACT           |                     P=0.273         P=0.146N       |                     P=0.607N        P=0.227        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     9/50 (18%)     16/50 (32%)     12/50 (24%)     |     4/50 (8%)       2/50 (4%)       2/50 (4%)      |
|ADJUSTED (b)           |     23.1%           38.8%           29.2%          |     13.5%            7.7%           12.5%          |
|TERMINAL (d)           |     2/30 (7%)       5/27 (19%)      2/28 (7%)      |     2/24 (8%)       1/25 (4%)       2/16 (13%)     |
|FIRST INCIDENCE (DAYS) |      599             676             596           |      410             704             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.262         P=0.125         P=0.294        |     P=0.378N        P=0.335N        P=0.498N       |
|INCIDENTAL TUMOR       |     P=0.366         P=0.305         P=0.433        |     P=0.281N        P=0.380N        P=0.406N       |
|LOGISTIC REGRESSION    |     P=0.291         P=0.222         P=0.345        |     P=0.303N        P=0.349N        P=0.387N       |
|COCHRAN-ARMITAGE       |     P=0.281                                        |     P=0.252N                                       |
|FISHER EXACT           |                     P=0.083         P=0.312        |                     P=0.339N        P=0.339N       |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE   6
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     9/50 (18%)     16/50 (32%)     12/50 (24%)     |     4/50 (8%)       2/50 (4%)       3/50 (6%)      |
|ADJUSTED (b)           |     23.1%           38.8%           29.2%          |     13.5%            7.7%           16.7%          |
|TERMINAL (d)           |     2/30 (7%)       5/27 (19%)      2/28 (7%)      |     2/24 (8%)       1/25 (4%)       2/16 (13%)     |
|FIRST INCIDENCE (DAYS) |      599             676             596           |      410             704             702           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.262         P=0.125         P=0.294        |     P=0.569N        P=0.335N        P=0.636        |
|INCIDENTAL TUMOR       |     P=0.366         P=0.305         P=0.433        |     P=0.429N        P=0.380N        P=0.542N       |
|LOGISTIC REGRESSION    |     P=0.291         P=0.222         P=0.345        |     P=0.487N        P=0.349N        P=0.567N       |
|COCHRAN-ARMITAGE       |     P=0.281                                        |     P=0.417N                                       |
|FISHER EXACT           |                     P=0.083         P=0.312        |                     P=0.339N        P=0.500N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    26/50 (52%)     34/50 (68%)     24/50 (48%)     |    11/50 (22%)     10/50 (20%)     14/50 (28%)     |
|ADJUSTED (b)           |     60.1%           78.4%           58.8%          |     37.1%           36.1%           63.8%          |
|TERMINAL (d)           |    13/30 (43%)     18/27 (67%)     12/28 (43%)     |     7/24 (29%)      8/25 (32%)      9/16 (56%)     |
|FIRST INCIDENCE (DAYS) |      424             651             596           |      410             438             381           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.508N        P=0.122         P=0.523N       |     P=0.067         P=0.479N        P=0.082        |
|INCIDENTAL TUMOR       |     P=0.329N        P=0.244         P=0.342N       |     P=0.151         P=0.520N        P=0.178        |
|LOGISTIC REGRESSION    |     P=0.360N        P=0.115         P=0.403N       |     P=0.151         P=0.544N        P=0.187        |
|COCHRAN-ARMITAGE       |     P=0.381N                                       |     P=0.277                                        |
|FISHER EXACT           |                     P=0.076         P=0.421N       |                     P=0.500N        P=0.322        |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE   7
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    26/50 (52%)     34/50 (68%)     24/50 (48%)     |    11/50 (22%)     10/50 (20%)     15/50 (30%)     |
|ADJUSTED (b)           |     60.1%           78.4%           58.8%          |     37.1%           36.1%           65.5%          |
|TERMINAL (d)           |    13/30 (43%)     18/27 (67%)     12/28 (43%)     |     7/24 (29%)      8/25 (32%)      9/16 (56%)     |
|FIRST INCIDENCE (DAYS) |      424             651             596           |      410             438             381           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.508N        P=0.122         P=0.523N       |     P=0.042 *       P=0.479N        P=0.053        |
|INCIDENTAL TUMOR       |     P=0.329N        P=0.244         P=0.342N       |     P=0.108         P=0.520N        P=0.133        |
|LOGISTIC REGRESSION    |     P=0.360N        P=0.115         P=0.403N       |     P=0.099         P=0.544N        P=0.126        |
|COCHRAN-ARMITAGE       |     P=0.381N                                       |     P=0.206                                        |
|FISHER EXACT           |                     P=0.076         P=0.421N       |                     P=0.500N        P=0.247        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/50 (14%)      7/32 (22%)      4/50 (8%)      |     2/50 (4%)       1/27 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |     22.0%           40.2%           13.4%          |      7.9%           50.0%            6.3%          |
|TERMINAL (d)           |     6/30 (20%)      3/9 (33%)       3/28 (11%)     |     1/24 (4%)       1/2 (50%)       1/16 (6%)      |
|FIRST INCIDENCE (DAYS) |      691             682             705           |      704             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.282N        P=0.125         P=0.300N       |     P=0.534N        P=0.598         P=0.623N       |
|INCIDENTAL TUMOR       |     P=0.263N        P=0.215         P=0.293N       |     P=0.486N        P=0.546         P=0.553N       |
|LOGISTIC REGRESSION    |     P=0.257N        P=0.231         P=0.287N       |     P=0.513N        P=0.387         P=0.599N       |
|COCHRAN-ARMITAGE       |     P=0.233N                                       |     P=0.387N                                       |
|FISHER EXACT           |                     P=0.264         P=0.262N       |                     P=0.720N        P=0.500N       |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE   8
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/50 (12%)      5/32 (16%)      5/50 (10%)     |     0/50 (0%)       1/27 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |     18.7%           45.7%           17.9%          |      0.0%            3.6%            4.2%          |
|TERMINAL (d)           |     5/30 (17%)      4/9 (44%)       5/28 (18%)     |     0/24 (0%)       0/2 (0%)        0/16 (0%)      |
|FIRST INCIDENCE (DAYS) |      691             691             729 (T)       |      ---             661             677           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.494N        P=0.149         P=0.548N       |     P=0.294         P=0.480         P=0.469        |
|INCIDENTAL TUMOR       |     P=0.490N        P=0.194         P=0.545N       |     P=0.425         P=0.433         P=0.571        |
|LOGISTIC REGRESSION    |     P=0.483N        P=0.324         P=0.541N       |     P=0.314         P=0.273         P=0.474        |
|COCHRAN-ARMITAGE       |     P=0.439N                                       |     P=0.344                                        |
|FISHER EXACT           |                     P=0.438         P=0.500N       |                     P=0.351         P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    11/50 (22%)     12/32 (38%)      8/50 (16%)     |     2/50 (4%)       2/27 (7%)       2/50 (4%)      |
|ADJUSTED (b)           |     33.4%           80.5%           27.3%          |      7.9%           51.8%           10.2%          |
|TERMINAL (d)           |     9/30 (30%)      7/9 (78%)       7/28 (25%)     |     1/24 (4%)       1/2 (50%)       1/16 (6%)      |
|FIRST INCIDENCE (DAYS) |      691             682             705           |      704             661             677           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.348N        P=0.013 *       P=0.361N       |     P=0.448         P=0.321         P=0.579        |
|INCIDENTAL TUMOR       |     P=0.329N        P=0.030 *       P=0.352N       |     P=0.562         P=0.250         P=0.690        |
|LOGISTIC REGRESSION    |     P=0.318N        P=0.066         P=0.344N       |     P=0.479         P=0.102         P=0.611        |
|COCHRAN-ARMITAGE       |     P=0.278N                                       |     P=0.593N                                       |
|FISHER EXACT           |                     P=0.102         P=0.306N       |                     P=0.439         P=0.691N       |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE   9
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     1/50 (2%)       0/50 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      4.2%            0.0%           12.5%          |
|TERMINAL (d)           |     0/30 (0%)       0/27 (0%)       0/28 (0%)      |     1/24 (4%)       0/25 (0%)       2/16 (13%)     |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      729 (T)         ---             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.255         P=0.492N        P=0.358        |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.255         P=0.492N        P=0.358        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.255         P=0.492N        P=0.358        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.360                                        |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.500N        P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     1/50 (2%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      3.4%            6.0%            0.0%          |
|TERMINAL (d)           |     0/30 (0%)       0/27 (0%)       0/28 (0%)      |     0/24 (0%)       0/25 (0%)       0/16 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      675             583             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.420N        P=0.468         P=0.538N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.330N        P=0.429         P=0.429N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.362N        P=0.501         P=0.526N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.360N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.500         P=0.500N       |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE  10
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     1/45 (2%)       0/36 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |                                                    |      5.0%            0.0%           12.5%          |
|TERMINAL (d)           |                                                    |     1/20 (5%)       0/11 (0%)       2/16 (13%)     |
|FIRST INCIDENCE (DAYS) |                                                    |      729 (T)         ---             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.304         P=0.619N        P=0.421        |
|INCIDENTAL TUMOR       |                                                    |     P=0.304         P=0.619N        P=0.421        |
|LOGISTIC REGRESSION    |                                                    |     P=0.304         P=0.619N        P=0.421        |
|COCHRAN-ARMITAGE       |                                                    |     P=0.396                                        |
|FISHER EXACT           |                                                    |                     P=0.556N        P=0.540        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/44 (0%)       0/50 (0%)       0/47 (0%)      |     7/47 (15%)      5/49 (10%)      3/50 (6%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     26.5%           20.0%           18.8%          |
|TERMINAL (d)           |     0/27 (0%)       0/27 (0%)       0/25 (0%)      |     4/22 (18%)      5/25 (20%)      3/16 (19%)     |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      674             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.224N        P=0.324N        P=0.300N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.163N        P=0.366N        P=0.200N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.178N        P=0.358N        P=0.232N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.101N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.350N        P=0.134N       |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE  11
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            7.4%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/30 (0%)       2/27 (7%)       0/28 (0%)      |     0/24 (0%)       0/25 (0%)       0/16 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             729 (T)         ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.652         P=0.215           (e)          |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.652         P=0.215           (e)          |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.652         P=0.215           (e)          |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.669                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.247           (e)          |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     2/50 (4%)       1/50 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      6.0%            2.7%            0.0%          |
|TERMINAL (d)           |     0/30 (0%)       0/27 (0%)       0/28 (0%)      |     0/24 (0%)       0/25 (0%)       0/16 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      410             549             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.176N        P=0.509N        P=0.298N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.114N        P=0.554N        P=0.164N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.134N        P=0.492N        P=0.227N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.142N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.500N        P=0.247N       |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE  12
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       1/50 (2%)       5/50 (10%)     |     2/50 (4%)       3/50 (6%)       0/50 (0%)      |
|ADJUSTED (b)           |      9.2%            3.1%           14.9%          |      8.0%           10.5%            0.0%          |
|TERMINAL (d)           |     1/30 (3%)       0/27 (0%)       2/28 (7%)      |     1/24 (4%)       2/25 (8%)       0/16 (0%)      |
|FIRST INCIDENCE (DAYS) |      710             716             612           |      705             549             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.240         P=0.310N        P=0.324        |     P=0.289N        P=0.506         P=0.330N       |
|INCIDENTAL TUMOR       |     P=0.297         P=0.166N        P=0.395        |     P=0.239N        P=0.469         P=0.241N       |
|LOGISTIC REGRESSION    |     P=0.265         P=0.276N        P=0.357        |     P=0.241N        P=0.480         P=0.295N       |
|COCHRAN-ARMITAGE       |     P=0.264                                        |     P=0.202N                                       |
|FISHER EXACT           |                     P=0.309N        P=0.357        |                     P=0.500         P=0.247N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       1/50 (2%)       1/50 (2%)      |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            3.7%            2.1%          |      0.0%            8.0%            0.0%          |
|TERMINAL (d)           |     0/30 (0%)       1/27 (4%)       0/28 (0%)      |     0/24 (0%)       2/25 (8%)       0/16 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             729 (T)         596           |      ---             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.330         P=0.479         P=0.509        |     P=0.592         P=0.246           (e)          |
|INCIDENTAL TUMOR       |     P=0.446         P=0.479         P=0.662        |     P=0.592         P=0.246           (e)          |
|LOGISTIC REGRESSION    |     P=0.311         P=0.479         P=0.456        |     P=0.592         P=0.246           (e)          |
|COCHRAN-ARMITAGE       |     P=0.331                                        |     P=0.669                                        |
|FISHER EXACT           |                     P=0.500         P=0.500        |                     P=0.247           (e)          |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE  13
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       1/50 (2%)       0/50 (0%)      |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            3.7%            0.0%          |      0.0%            8.0%            0.0%          |
|TERMINAL (d)           |     0/30 (0%)       1/27 (4%)       0/28 (0%)      |     0/24 (0%)       2/25 (8%)       0/16 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             729 (T)         ---           |      ---             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.718         P=0.479           (e)          |     P=0.592         P=0.246           (e)          |
|INCIDENTAL TUMOR       |     P=0.718         P=0.479           (e)          |     P=0.592         P=0.246           (e)          |
|LOGISTIC REGRESSION    |     P=0.718         P=0.479           (e)          |     P=0.592         P=0.246           (e)          |
|COCHRAN-ARMITAGE       |     P=0.731                                        |     P=0.669                                        |
|FISHER EXACT           |                     P=0.500           (e)          |                     P=0.247           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     0/50 (0%)       2/50 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |                                                    |      0.0%            6.0%            3.6%          |
|TERMINAL (d)           |                                                    |     0/24 (0%)       0/25 (0%)       0/16 (0%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      ---             583             612           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.305         P=0.218         P=0.461        |
|INCIDENTAL TUMOR       |                                                    |     P=0.358         P=0.202         P=0.500        |
|LOGISTIC REGRESSION    |                                                    |     P=0.365         P=0.240         P=0.500        |
|COCHRAN-ARMITAGE       |                                                    |     P=0.360                                        |
|FISHER EXACT           |                                                    |                     P=0.247         P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE  14
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       2/50 (4%)       0/50 (0%)      |     1/50 (2%)       1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |      3.3%            7.4%            0.0%          |      3.2%            4.0%            3.2%          |
|TERMINAL (d)           |     1/30 (3%)       2/27 (7%)       0/28 (0%)      |     0/24 (0%)       1/25 (4%)       0/16 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         729 (T)         ---           |      674             729 (T)         576           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.381N        P=0.463         P=0.514N       |     P=0.564         P=0.750         P=0.709        |
|INCIDENTAL TUMOR       |     P=0.381N        P=0.463         P=0.514N       |     P=0.633N        P=0.728         P=0.721N       |
|LOGISTIC REGRESSION    |     P=0.381N        P=0.463         P=0.514N       |     P=0.618         P=0.752         P=0.760        |
|COCHRAN-ARMITAGE       |     P=0.360N                                       |     P=0.640                                        |
|FISHER EXACT           |                     P=0.500         P=0.500N       |                     P=0.753N        P=0.753N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       8/50 (16%)     10/50 (20%)     |     5/50 (10%)      3/50 (6%)       3/50 (6%)      |
|ADJUSTED (b)           |     11.6%           20.0%           29.9%          |     17.8%           10.5%           18.8%          |
|TERMINAL (d)           |     1/30 (3%)       1/27 (4%)       6/28 (21%)     |     3/24 (13%)      2/25 (8%)       3/16 (19%)     |
|FIRST INCIDENCE (DAYS) |      701             682             612           |      410             549             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.056         P=0.215         P=0.068        |     P=0.451N        P=0.349N        P=0.569N       |
|INCIDENTAL TUMOR       |     P=0.052         P=0.478         P=0.079        |     P=0.379N        P=0.376N        P=0.476N       |
|LOGISTIC REGRESSION    |     P=0.043 *       P=0.416         P=0.071        |     P=0.348N        P=0.370N        P=0.443N       |
|COCHRAN-ARMITAGE       |     P=0.060                                        |     P=0.283N                                       |
|FISHER EXACT           |                     P=0.178         P=0.074        |                     P=0.357N        P=0.357N       |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE  15
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)     10/50 (20%)     10/50 (20%)     |     6/50 (12%)      4/50 (8%)       4/50 (8%)      |
|ADJUSTED (b)           |     14.7%           26.2%           29.9%          |     20.4%           14.4%           21.4%          |
|TERMINAL (d)           |     2/30 (7%)       3/27 (11%)      6/28 (21%)     |     3/24 (13%)      3/25 (12%)      3/16 (19%)     |
|FIRST INCIDENCE (DAYS) |      701             682             612           |      410             549             576           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.103         P=0.155         P=0.116        |     P=0.496N        P=0.370N        P=0.591N       |
|INCIDENTAL TUMOR       |     P=0.105         P=0.347         P=0.136        |     P=0.391N        P=0.406N        P=0.455N       |
|LOGISTIC REGRESSION    |     P=0.091         P=0.159         P=0.124        |     P=0.374N        P=0.389N        P=0.447N       |
|COCHRAN-ARMITAGE       |     P=0.114                                        |     P=0.303N                                       |
|FISHER EXACT           |                     P=0.131         P=0.131        |                     P=0.370N        P=0.370N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       6/50 (12%)      9/50 (18%)     |     8/50 (16%)      9/50 (18%)     12/50 (24%)     |
|ADJUSTED (b)           |     11.1%           16.8%           22.7%          |     27.9%           27.8%           52.3%          |
|TERMINAL (d)           |     2/30 (7%)       2/27 (7%)       3/28 (11%)     |     5/24 (21%)      4/25 (16%)      6/16 (38%)     |
|FIRST INCIDENCE (DAYS) |      491             592             467           |      477             472             583           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.088         P=0.374         P=0.118        |     P=0.060         P=0.490         P=0.065        |
|INCIDENTAL TUMOR       |     P=0.097         P=0.278         P=0.108        |     P=0.155         P=0.435         P=0.157        |
|LOGISTIC REGRESSION    |     P=0.067         P=0.325         P=0.092        |     P=0.105         P=0.475         P=0.103        |
|COCHRAN-ARMITAGE       |     P=0.088                                        |     P=0.188                                        |
|FISHER EXACT           |                     P=0.370         P=0.117        |                     P=0.500         P=0.227        |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE  16
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       6/50 (12%)      8/50 (16%)     |     7/50 (14%)      9/50 (18%)     12/50 (24%)     |
|ADJUSTED (b)           |     11.1%           16.8%           20.9%          |     26.2%           27.8%           52.3%          |
|TERMINAL (d)           |     2/30 (7%)       2/27 (7%)       3/28 (11%)     |     5/24 (21%)      4/25 (16%)      6/16 (38%)     |
|FIRST INCIDENCE (DAYS) |      491             592             467           |      674             472             583           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.137         P=0.374         P=0.175        |     P=0.033 *       P=0.391         P=0.036 *      |
|INCIDENTAL TUMOR       |     P=0.131         P=0.278         P=0.140        |     P=0.090         P=0.328         P=0.085        |
|LOGISTIC REGRESSION    |     P=0.114         P=0.325         P=0.149        |     P=0.057         P=0.360         P=0.049 *      |
|COCHRAN-ARMITAGE       |     P=0.141                                        |     P=0.124                                        |
|FISHER EXACT           |                     P=0.370         P=0.178        |                     P=0.393         P=0.154        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            6.6%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/30 (0%)       1/27 (4%)       0/28 (0%)      |     0/24 (0%)       0/25 (0%)       0/16 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             715             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.657         P=0.235           (e)          |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.668         P=0.292           (e)          |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.662         P=0.253           (e)          |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.669                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.247           (e)          |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE  17
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma or Osteoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            6.6%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/30 (0%)       1/27 (4%)       0/28 (0%)      |     0/24 (0%)       0/25 (0%)       0/16 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             715             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.657         P=0.235           (e)          |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.668         P=0.292           (e)          |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.662         P=0.253           (e)          |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.669                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.247           (e)          |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    29/50 (58%)     36/50 (72%)     25/50 (50%)     |    21/50 (42%)     19/50 (38%)     18/50 (36%)     |
|ADJUSTED (b)           |     70.2%           85.2%           70.9%          |     62.7%           67.1%           72.2%          |
|TERMINAL (d)           |    18/30 (60%)     21/27 (78%)     18/28 (64%)     |    12/24 (50%)     16/25 (64%)     10/16 (63%)     |
|FIRST INCIDENCE (DAYS) |      424             651             596           |      477             438             381           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.388N        P=0.124         P=0.402N       |     P=0.304         P=0.407N        P=0.344        |
|INCIDENTAL TUMOR       |     P=0.278N        P=0.220         P=0.307N       |     P=0.515N        P=0.482N        P=0.508N       |
|LOGISTIC REGRESSION    |     P=0.236N        P=0.185         P=0.272N       |     P=0.544N        P=0.511N        P=0.568N       |
|COCHRAN-ARMITAGE       |     P=0.237N                                       |     P=0.304N                                       |
|FISHER EXACT           |                     P=0.104         P=0.274N       |                     P=0.419N        P=0.341N       |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE  18
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         20 MG/KG        40 MG/KG      |      VEHICLE         20 MG/KG        40 MG/KG      |
|                       |      15 SSAC         15 SSAC         15 SSAC       |      15 SSAC         15 SSAC         15 SSAC       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    21/50 (42%)     30/50 (60%)     35/50 (70%)     |    19/50 (38%)     20/50 (40%)     23/50 (46%)     |
|ADJUSTED (b)           |     50.3%           64.2%           74.2%          |     57.8%           58.3%           81.3%          |
|TERMINAL (d)           |    10/30 (33%)     11/27 (41%)     16/28 (57%)     |    11/24 (46%)     11/25 (44%)     11/16 (69%)     |
|FIRST INCIDENCE (DAYS) |      491             592             467           |       81             472             571           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.013 *       P=0.112         P=0.015 *      |     P=0.038 *       P=0.498         P=0.040 *      |
|INCIDENTAL TUMOR       |     P=0.005 **      P=0.224         P=0.006 **     |     P=0.140         P=0.405         P=0.145        |
|LOGISTIC REGRESSION    |     P=0.007 **      P=0.067         P=0.005 **     |     P=0.099         P=0.453         P=0.068        |
|COCHRAN-ARMITAGE       |     P=0.003 **                                     |     P=0.239                                        |
|FISHER EXACT           |                     P=0.055         P=0.004 **     |                     P=0.500         P=0.272        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    38/50 (76%)     47/50 (94%)     46/50 (92%)     |    32/50 (64%)     31/50 (62%)     30/50 (60%)     |
|ADJUSTED (b)           |     80.8%           94.0%           95.8%          |     86.0%           83.5%           93.6%          |
|TERMINAL (d)           |    21/30 (70%)     24/27 (89%)     26/28 (93%)     |    19/24 (79%)     19/25 (76%)     14/16 (88%)     |
|FIRST INCIDENCE (DAYS) |      424             592             467           |       81             438             381           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.071         P=0.102         P=0.085        |     P=0.128         P=0.498N        P=0.132        |
|INCIDENTAL TUMOR       |     P=0.020 *       P=0.068         P=0.035 *      |     P=0.511         P=0.567         P=0.533        |
|LOGISTIC REGRESSION    |     P=0.018 *       P=0.023 *       P=0.035 *      |     P=0.374         P=0.587N        P=0.339        |
|COCHRAN-ARMITAGE       |     P=0.012 *                                      |     P=0.379N                                       |
|FISHER EXACT           |                     P=0.011 *       P=0.027 *      |                     P=0.500N        P=0.418N       |
|=================================================================================================================================|
 
         DATE: 09/05/94                     EXPERIMENT: 05037 TEST: 04                                                 PAGE  19
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).