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TDMS Study 05040-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            HYDROQUINONE


NTP Experiment-Test: 05040-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 11:58:38




       Facility:  American Biogenics Corp.

       Chemical CAS #:  000123319

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05040-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 11:58:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          65           65           65                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           7           11            6                                                  
    Dead                                              11            5            9                                                  
    Accident                                                                     4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           39           36                                                  
  Animals Examined Microscopically                    55           55           55                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (50)         (12)         (48)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Mucosa, Hyperplasia, Focal                                                 1 (2%)                                             
   Intestine Large, Cecum                             (52)         (13)         (53)                                                
      Colon, Serosa, Inflammation, Chronic                          1 (8%)                                                          
   Intestine Small, Duodenum                          (52)         (15)         (51)                                                
      Muscularis, Inflammation, Acute                               1 (7%)                                                          
      Serosa, Ileum, Jejunum, Inflammation, Chronic                 1 (7%)                                                          
   Intestine Small, Ileum                             (49)         (14)         (52)                                                
      Amyloid Deposition                               1 (2%)                    1 (2%)                                             
   Intestine Small, Jejunum                           (52)         (12)         (52)                                                
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                                                       
   Liver                                              (55)         (55)         (55)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Angiectasis                                      1 (2%)       2 (4%)                                                          
      Basophilic Focus                                 2 (4%)       6 (11%)      3 (5%)                                             
      Congestion                                       1 (2%)                                                                       
      Cyst                                                          1 (2%)       1 (2%)                                             
      Eosinophilic Focus                               3 (5%)       3 (5%)       2 (4%)                                             
      Fatty Change                                     4 (7%)       2 (4%)                                                          
      Focal Cellular Change                                                      1 (2%)                                             
      Hematopoietic Cell Proliferation                 3 (5%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Inflammation, Chronic                            5 (9%)       4 (7%)       5 (9%)                                             
      Inflammation, Focal, Granulomatous               1 (2%)                                                                       
      Mixed Cell Focus                                 1 (2%)                                                                       
      Necrosis                                         3 (5%)       2 (4%)       2 (4%)                                             
      Biliary Tract, Inflammation, Chronic             1 (2%)                                                                       
      Kupffer Cell, Hyperplasia                        1 (2%)                                                                       
   Mesentery                                          (19)         (12)         (4)                                                 
      Inflammation, Chronic                            2 (11%)      1 (8%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05040-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 11:58:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Suppurative                        1 (5%)       1 (8%)                                                          
      Necrosis, Focal                                               1 (8%)                                                          
      Fat, Hemorrhage, Focal                           1 (5%)                                                                       
      Fat, Necrosis, Focal                            11 (58%)      6 (50%)      2 (50%)                                            
      Fat, Lymphatic, Hemorrhage, Focal                1 (5%)                                                                       
      Perivascular, Inflammation, Chronic              1 (5%)                                                                       
   Pancreas                                           (54)         (16)         (53)                                                
      Inflammation, Chronic                            1 (2%)       3 (19%)      1 (2%)                                             
      Inflammation, Subacute                           1 (2%)                                                                       
      Duct, Ectasia                                    1 (2%)       1 (6%)                                                          
   Salivary Glands                                    (54)         (54)         (54)                                                
      Inflammation, Chronic                           25 (46%)     34 (63%)     33 (61%)                                            
   Stomach, Glandular                                 (53)         (16)         (55)                                                
      Erosion, Focal                                                1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (55)         (17)         (55)                                                
      Cardiomyopathy                                   1 (2%)                                                                       
      Hemorrhage                                                    1 (6%)                                                          
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Atrioventricular Valve, Inflammation,                                                                                         
          Subacute                                     1 (2%)                                                                       
      Atrium, Thrombosis                               1 (2%)       1 (6%)                                                          
      Coronary Artery, Inflammation, Chronic                        1 (6%)       1 (2%)                                             
      Epicardium, Inflammation, Chronic                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (55)         (13)         (55)                                                
      Degeneration, Diffuse                                                      1 (2%)                                             
      Degeneration, Focal                              2 (4%)                                                                       
      Hematopoietic Cell Proliferation                                           4 (7%)                                             
      Hyperplasia, Focal                               3 (5%)                    2 (4%)                                             
   Adrenal Gland, Medulla                             (51)         (11)         (52)                                                
      Hyperplasia, Focal                               1 (2%)                                                                       
   Pituitary Gland                                    (52)         (29)         (52)                                                
      Pars Distalis, Angiectasis                       1 (2%)       2 (7%)       4 (8%)                                             
      Pars Distalis, Hyperplasia, Focal               13 (25%)      4 (14%)     13 (25%)                                            
   Thyroid Gland                                      (55)         (55)         (55)                                                
      Inflammation, Chronic                            3 (5%)       4 (7%)       9 (16%)                                            
      Polyarteritis                                                 1 (2%)                                                          
      Follicle, Cyst                                                             1 (2%)                                             
      Follicular Cell, Hyperplasia                    13 (24%)     47 (85%)     45 (82%)                                            
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05040-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 11:58:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (55)         (53)         (54)                                                
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                            12 (22%)     12 (23%)     14 (26%)                                            
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
      Artery, Periovarian Tissue, Inflammation,                                                                                     
           Chronic                                                  1 (2%)                                                          
      Periovarian Tissue, Inflammation, Chronic        5 (9%)       5 (9%)       4 (7%)                                             
      Periovarian Tissue, Inflammation, Subacute       1 (2%)                                                                       
      Periovarian Tissue, Necrosis                                  1 (2%)                                                          
      Serosa, Hyperplasia, Papillary                                             1 (2%)                                             
   Uterus                                             (54)         (29)         (55)                                                
      Hydrometra                                       2 (4%)                    2 (4%)                                             
      Inflammation, Chronic                                         1 (3%)                                                          
      Endometrium, Hemorrhage                          1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                37 (69%)     18 (62%)     31 (56%)                                            
      Endometrium, Inflammation, Suppurative           2 (4%)                                                                       
      Myometrium, Hyperplasia                                                    1 (2%)                                             
      Submucosa, Angiectasis                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (55)         (16)         (54)                                                
      Hyperplasia                                                                1 (2%)                                             
   Lymph Node                                         (55)         (22)         (54)                                                
      Hyperplasia, Plasma Cell                                      1 (5%)       1 (2%)                                             
      Axillary, Hyperplasia, Lymphoid                  1 (2%)                                                                       
      Axillary, Hyperplasia, Plasma Cell                            1 (5%)       1 (2%)                                             
      Deep Cervical, Hyperplasia, Plasma Cell          1 (2%)                                                                       
      Iliac, Hematopoietic Cell Proliferation                       1 (5%)                                                          
      Inguinal, Hematopoietic Cell Proliferation       1 (2%)                                                                       
      Mediastinal, Hematopoietic Cell Proliferation    1 (2%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid                            2 (9%)                                                          
      Mediastinal, Hyperplasia, Plasma Cell                                      1 (2%)                                             
      Mediastinal, Inflammation, Suppurative           1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05040-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 11:58:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Renal, Hemorrhage                                             1 (5%)                                                          
   Lymph Node, Mandibular                             (50)         (16)         (49)                                                
      Hyperplasia, Lymphoid                            2 (4%)       1 (6%)       1 (2%)                                             
      Hyperplasia, Lymphoid, Plasma Cell               1 (2%)                                                                       
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
   Lymph Node, Mesenteric                             (52)         (17)         (52)                                                
      Congestion                                       1 (2%)                    2 (4%)                                             
      Cyst                                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       1 (6%)                                                          
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Lymphoid                                         2 (12%)      2 (4%)                                             
      Hyperplasia, Lymphoid, Plasma Cell               1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
   Spleen                                             (55)         (22)         (55)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Fibrosis                                                      1 (5%)                                                          
      Hematopoietic Cell Proliferation                 7 (13%)      2 (9%)       4 (7%)                                             
      Hyperplasia, Lymphoid                                         1 (5%)       1 (2%)                                             
      Pigmentation, Hemosiderin                                     1 (5%)                                                          
   Thymus                                             (44)         (13)         (47)                                                
      Ectopic Parathyroid Gland                                                  2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (52)         (20)         (53)                                                
      Hyperplasia                                      9 (17%)      1 (5%)       5 (9%)                                             
      Hyperplasia, Cystic                              1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Duct, Ectasia                                    1 (2%)                                                                       
   Skin                                               (55)         (16)         (55)                                                
      Ulcer                                            2 (4%)                    4 (7%)                                             
      Abdominal, Subcutaneous Tissue, Abscess                       1 (6%)                                                          
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                               1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (55)         (16)         (55)                                                
      Fibrous Osteodystrophy                           5 (9%)                    3 (5%)                                             
      Joint, Tarsal, Hyperostosis                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05040-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 11:58:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (55)         (16)         (55)                                                
      Atrophy                                                                    1 (2%)                                             
      Hemorrhage, Focal                                                          1 (2%)                                             
      Mineralization                                   5 (9%)                    3 (5%)                                             
      Cerebrum, Hemorrhage                                          1 (6%)                                                          
      Cerebrum, Inflammation, Chronic, Focal           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (55)         (55)         (55)                                                
      Atelectasis                                                                1 (2%)                                             
      Congestion                                       1 (2%)                    3 (5%)                                             
      Hemorrhage, Focal                                1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       1 (2%)       5 (9%)                                             
      Metaplasia, Osseous                                                        1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              1 (2%)                                                          
      Alveolus, Hyperplasia, Macrophage                             1 (2%)       2 (4%)                                             
      Artery, Hypertrophy                                                        1 (2%)                                             
      Artery, Capillary, Vein, Leukocytosis                                      1 (2%)                                             
      Peribronchiolar, Inflammation, Chronic                                     1 (2%)                                             
      Perivascular, Inflammation, Chronic              2 (4%)                    2 (4%)                                             
   Nose                                               (54)         (16)         (55)                                                
      Inflammation, Acute                                                        1 (2%)                                             
      Mucosa, Inflammation, Chronic                    1 (2%)                                                                       
      Nasolacrimal Duct, Foreign Body                  1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic                      1 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (5)                                                 
      Conjunctiva, Retrobulbar, Inflammation                                     1 (20%)                                            
   Lacrimal Gland                                                               (2)                                                 
      Inflammation, Chronic                                                      1 (50%)                                            
      Extraorbital, Inflammation, Chronic                                        1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (55)         (16)         (55)                                                
      Amyloid Deposition                               2 (4%)                    2 (4%)                                             
      Glomerulosclerosis                               1 (2%)                                                                       
      Inflammation, Chronic                           35 (64%)      8 (50%)     34 (62%)                                            
      Metaplasia, Focal, Osseous                                                 1 (2%)                                             
      Nephropathy                                                                1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05040-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 11:58:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50 MG/KG     100MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Cortex, Fibrosis, Focal                                                    1 (2%)                                             
      Cortex, Metaplasia, Osseous                      1 (2%)                                                                       
      Cortex, Necrosis, Focal                          1 (2%)                                                                       
      Renal Tubule, Pigmentation, Hemosiderin          1 (2%)                                                                       
   Urinary Bladder                                    (53)         (15)         (54)                                                
      Cytomegaly                                       1 (2%)                                                                       
      Muscularis, Submucosa, Inflammation                                        1 (2%)                                             
      Submucosa, Inflammation, Chronic                28 (53%)      4 (27%)     33 (61%)                                            
      Submucosa, Inflammation, Chronic, Hemorrhagic                              1 (2%)                                             
      Subserosa, Inflammation, Chronic                              1 (7%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05040-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 11:58:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          65           65           65                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          12           10            5                                                  
    Dead                                              10            7           14                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           37           36                                                  
  Wrong Sex                                                         1                                                               
  Animals Examined Microscopically                    55           54           55                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (44)         (11)         (48)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
   Intestine Small, Ileum                             (48)         (10)         (47)                                                
      Amyloid Deposition                               1 (2%)                                                                       
      Mucosa, Necrosis                                                           1 (2%)                                             
      Peyer's Patch, Hyperplasia, Lymphoid                                       1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (13)         (45)                                                
      Diverticulum                                                  1 (8%)                                                          
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Mucosa, Inflammation, Suppurative                             1 (8%)                                                          
   Liver                                              (55)         (54)         (55)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Anisokaryosis                                                 2 (4%)      12 (22%)                                            
      Autolysis                                                     1 (2%)                                                          
      Basophilic Focus                                 2 (4%)       5 (9%)      11 (20%)                                            
      Clear Cell Focus                                              2 (4%)                                                          
      Cyst                                             1 (2%)       1 (2%)       1 (2%)                                             
      Cytomegaly                                                                 3 (5%)                                             
      Eosinophilic Focus                               2 (4%)       3 (6%)       4 (7%)                                             
      Fatty Change                                                               3 (5%)                                             
      Focal Cellular Change                                         1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Hyperplasia, Re Cell                                                       1 (2%)                                             
      Infarct                                          1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Mixed Cell Focus                                 2 (4%)                    1 (2%)                                             
      Necrosis                                         4 (7%)       2 (4%)       2 (4%)                                             
      Necrosis, Focal                                  1 (2%)                                                                       
      Syncytial Alteration                             5 (9%)       3 (6%)      25 (45%)                                            
      Thrombosis                                       1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05040-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 11:58:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Degeneration, Ballooning                                    1 (2%)                                             
      Sinusoid, Dilatation, Focal                                                1 (2%)                                             
   Mesentery                                          (6)          (4)          (5)                                                 
      Hemorrhage                                       1 (17%)                                                                      
      Inflammation, Acute                              1 (17%)                   1 (20%)                                            
      Inflammation, Chronic                                         1 (25%)      1 (20%)                                            
      Inflammation, Suppurative                                     1 (25%)                                                         
      Fat, Inflammation, Chronic                                                 1 (20%)                                            
      Fat, Necrosis, Focal                             3 (50%)                   1 (20%)                                            
   Pancreas                                           (54)         (15)         (53)                                                
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hemorrhage, Focal                                1 (2%)                                                                       
      Inflammation, Chronic                                                      2 (4%)                                             
      Acinus, Vacuolization Cytoplasmic                                          1 (2%)                                             
      Serosa, Inflammation, Acute                                                1 (2%)                                             
   Salivary Glands                                    (55)         (16)         (55)                                                
      Concretion, Chronic                                                        1 (2%)                                             
      Degeneration, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic                           30 (55%)      8 (50%)     31 (56%)                                            
   Stomach, Forestomach                               (55)         (15)         (53)                                                
      Acanthosis                                                                 1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
   Stomach, Glandular                                 (55)         (15)         (55)                                                
      Ulcer                                            1 (2%)                    1 (2%)                                             
   Tooth                                              (6)          (1)          (2)                                                 
      Peridontal Tissue, Inflammation, Suppurative     2 (33%)                   1 (50%)                                            
      Peridontal Tissue, Pulp, Abscess                 1 (17%)                                                                      
      Pulp, Abscess                                    2 (33%)                   1 (50%)                                            
      Pulp, Necrosis                                   1 (17%)      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (55)         (17)         (55)                                                
      Cardiomyopathy                                                             1 (2%)                                             
      Inflammation, Acute                              1 (2%)       1 (6%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Atrium Left, Thrombosis                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (55)         (53)         (54)                                                
      Subcapsular, Hyperplasia                         1 (2%)                                                                       
   Adrenal Gland, Cortex                              (55)         (52)         (54)                                                
      Degeneration, Focal                              5 (9%)       1 (2%)                                                          
      Ectopic Tissue                                   1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05040-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 11:58:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia, Focal                               9 (16%)      2 (4%)       6 (11%)                                            
      Hypertrophy, Focal                               1 (2%)                    1 (2%)                                             
      Spindle Cell, Subcapsular, Proliferation                      1 (2%)                                                          
   Adrenal Gland, Medulla                             (54)         (52)         (54)                                                
      Hyperplasia, Focal                               1 (2%)       3 (6%)       1 (2%)                                             
   Pituitary Gland                                    (50)         (14)         (50)                                                
      Pars Distalis, Hyperplasia, Focal                3 (6%)       1 (7%)       5 (10%)                                            
   Thyroid Gland                                      (55)         (53)         (54)                                                
      Inflammation, Chronic                                         1 (2%)       2 (4%)                                             
      Inflammation, Suppurative                                     1 (2%)                                                          
      Follicle, Cyst, Multiple                         1 (2%)                                                                       
      Follicle, Inflammation, Acute                                              1 (2%)                                             
      Follicular Cell, Hyperplasia                     5 (9%)      15 (28%)     19 (35%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (54)         (17)         (54)                                                
      Inflammation, Chronic                            1 (2%)                    3 (6%)                                             
   Preputial Gland                                    (11)         (9)          (7)                                                 
      Inflammation, Chronic                            5 (45%)      3 (33%)      2 (29%)                                            
      Inflammation, Suppurative                        5 (45%)      6 (67%)      4 (57%)                                            
      Duct, Ectasia                                    1 (9%)       1 (11%)      1 (14%)                                            
   Prostate                                           (55)         (17)         (55)                                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                            6 (11%)      1 (6%)       9 (16%)                                            
      Inflammation, Chronic Active                     3 (5%)                                                                       
      Inflammation, Suppurative                        1 (2%)       1 (6%)                                                          
      Serosa, Inflammation, Acute                                                1 (2%)                                             
   Seminal Vesicle                                    (55)         (17)         (55)                                                
      Dilatation                                       1 (2%)                                                                       
      Inflammation, Chronic                            2 (4%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Serosa, Inflammation, Acute                                                1 (2%)                                             
   Testes                                             (55)         (18)         (55)                                                
      Atrophy                                          2 (4%)                    1 (2%)                                             
      Germinal Epithelium, Degeneration                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05040-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 11:58:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (55)         (29)         (55)                                                
      Congestion                                                    1 (3%)                                                          
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Hyperplasia, Lymphoid, Plasma Cell                            1 (3%)                                                          
      Hyperplasia, Plasma Cell                         1 (2%)       1 (3%)                                                          
      Inflammation, Acute                                                        1 (2%)                                             
      Axillary, Hyperplasia, Lymphoid                  1 (2%)                                                                       
      Axillary, Hyperplasia, Plasma Cell               1 (2%)                    1 (2%)                                             
      Iliac, Hematopoietic Cell Proliferation                       1 (3%)                                                          
      Iliac, Hyperplasia                                            1 (3%)                                                          
      Iliac, Hyperplasia, Lymphoid                     1 (2%)                                                                       
      Iliac, Hyperplasia, Plasma Cell                  1 (2%)       1 (3%)                                                          
      Inguinal, Cyst                                   1 (2%)                                                                       
      Inguinal, Hyperplasia, Lymphoid                               1 (3%)                                                          
      Lumbar, Congestion                               1 (2%)                                                                       
      Lumbar, Hyperplasia, Lymphoid                    1 (2%)                                                                       
      Mediastinal, Hyperplasia                         1 (2%)                                                                       
      Pancreatic, Congestion                           1 (2%)                                                                       
      Popliteal, Hyperplasia, Lymphoid                 1 (2%)                                                                       
      Popliteal, Hyperplasia, Plasma Cell              1 (2%)                                                                       
      Renal, Hyperplasia, Lymphoid                     1 (2%)                                                                       
      Renal, Hyperplasia, Plasma Cell                  1 (2%)                                                                       
   Lymph Node, Mandibular                             (52)         (17)         (51)                                                
      Congestion                                       2 (4%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Hyperplasia, Plasma Cell                                                   5 (10%)                                            
   Lymph Node, Mesenteric                             (54)         (23)         (50)                                                
      Congestion                                      11 (20%)      6 (26%)     10 (20%)                                            
      Hematopoietic Cell Proliferation                 1 (2%)       1 (4%)       1 (2%)                                             
      Hyperplasia, Lymphoid                            3 (6%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
   Spleen                                             (55)         (52)         (54)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Hematopoietic Cell Proliferation                10 (18%)     14 (27%)      6 (11%)                                            
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
   Thymus                                             (39)         (10)         (42)                                                
      Amyloid Deposition                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (55)         (33)         (55)                                                
      Acanthosis                                       2 (4%)       3 (9%)       2 (4%)                                             
      Alopecia                                                                   1 (2%)                                             
      Atrophy                                          2 (4%)       3 (9%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       1 (3%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05040-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 11:58:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Ulcer                                            5 (9%)       6 (18%)     14 (25%)                                            
      Artery, Subcutaneous Tissue, Inflammation,                                                                                    
           Chronic                                     1 (2%)                                                                       
      Dermis, Fibrosis                                 1 (2%)                                                                       
      Dermis, Inflammation, Chronic                    1 (2%)       1 (3%)       2 (4%)                                             
      Dermis, Dorsal, Atrophy                                                    1 (2%)                                             
      Prepuce, Inflammation, Chronic                   2 (4%)                                                                       
      Prepuce, Inflammation, Suppurative                            1 (3%)                                                          
      Subcutaneous Tissue, Edema                       2 (4%)                                                                       
      Subcutaneous Tissue, Hemorrhage                  1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic       1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Subacute      1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                  1 (2%)       1 (3%)                                                          
      Tail, Dermis, Inflammation                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (54)         (32)         (55)                                                
      Hyperostosis                                                  5 (16%)                                                         
      Joint, Tarsal, Hyperostosis                     10 (19%)     10 (31%)      7 (13%)                                            
   Skeletal Muscle                                    (3)                                                                           
      Abdominal, Fibrosis                              1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (55)         (17)         (55)                                                
      Cyst Epithelial Inclusion                                     1 (6%)                                                          
      Mineralization                                   2 (4%)                    3 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (55)         (31)         (55)                                                
      Congestion                                                    4 (13%)                                                         
      Hemorrhage                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              1 (3%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Atypical                    1 (3%)                                                          
      Alveolus, Hyperplasia, Macrophage                1 (2%)       1 (3%)       2 (4%)                                             
      Vein, Leukocytosis                                            1 (3%)                                                          
   Nose                                               (55)         (17)         (55)                                                
      Lumen, Turbinate, Inflammation, Suppurative      2 (4%)                    1 (2%)                                             
      Mucosa, Inflammation, Chronic                                              1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic         2 (4%)                    3 (5%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05040-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 11:58:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50 MG/KG     100MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Lacrimal Gland                                                  (1)          (1)                                                 
      Extraorbital, Inflammation, Chronic                                        1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (55)         (17)         (55)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Calculus Micro Observation Only                  2 (4%)                                                                       
      Cyst, Multiple                                   1 (2%)                                                                       
      Cytoplasmic Alteration                                        1 (6%)                                                          
      Glomerulosclerosis                               3 (5%)                    1 (2%)                                             
      Inflammation, Chronic                           45 (82%)     11 (65%)     44 (80%)                                            
      Inflammation, Suppurative                        1 (2%)       1 (6%)                                                          
      Nephropathy                                      1 (2%)       1 (6%)       1 (2%)                                             
      Cortex, Infarct                                  1 (2%)                                                                       
      Renal Tubule, Mineralization                                               2 (4%)                                             
   Urethra                                            (3)                       (2)                                                 
      Distal, Concretion                                                         1 (50%)                                            
      Distal, Inflammation, Chronic                    1 (33%)                                                                      
      Distal, Inflammation, Suppurative                                          1 (50%)                                            
      Proximal, Inflammation, Suppurative              2 (67%)                   1 (50%)                                            
   Urinary Bladder                                    (54)         (15)         (55)                                                
      Muscularis, Hemorrhage                                                     1 (2%)                                             
      Perivascular, Inflammation, Chronic              2 (4%)                                                                       
      Submucosa, Inflammation, Chronic                15 (28%)      2 (13%)     13 (24%)                                            
      Wall, Inflammation, Subacute                     1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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