National Toxicology Program

National Toxicology Program
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TDMS Study 05040-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: American Biogenics                                        DATE: 09/05/94   
EXP: 05040                      HYDROQUINONE                   TIME: 12:08:41   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 55834B   
CONT:                                                          CAS: 000123319   
PATHOLOGIST: S. WYAND                        S. EUSTIS                          
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REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: American Biogenics                                        DATE: 09/05/94  
EXP: 05040                      HYDROQUINONE                   TIME: 12:08:41  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 55834B  
CONT:                                                          CAS: 000123319  
PATHOLOGIST: S. WYAND                        S. EUSTIS                         

                                   HYDROQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 65     UNCENSORED DEATHS 22     CENSORED DEATHS 10   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      330   347   408   421   537   555   604   605   630   635                 |
 |      648   649   662   681   682   683   684   691   694   698                 |
 |      701   709                                                                 |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 50 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 64     UNCENSORED DEATHS 17     CENSORED DEATHS 10   TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      218   368   441   465   479   547   596   648   652   654                 |
 |      654   656   662   684   688   691   701                                   |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 65     UNCENSORED DEATHS 19     CENSORED DEATHS 10   TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      330   481   526   563   575   625   634   635   642   649                 |
 |      655   657   661   663   680   681   682   690   697                       |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |                                                                                |
 ==================================================================================

                                   HYDROQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0  96.9  93.8  93.8  92.0  86.5  77.3  60.7      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |50 MG/KG   |   100.0 100.0  98.4  98.4  96.9  91.6  91.6  87.8  76.6  69.1      |
 |           |                                                                    |
 |           |                                                                    |
 |100MG/KG   |   100.0 100.0 100.0  98.5  98.5  96.6  94.8  91.2  74.8  65.6      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          50 MG/KG         100MG/KG      |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       60.7%            69.1%            65.6%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.649N         P=0.494N         P=0.719N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       602.5            576.7            617.2         |
 |NATURAL DEATHS (C)      |       (25.4)           (33.4)           (20.8)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       644.5            646.2            654.6         |
 |(STANDARD ERROR)        |       (14.9)           (15.7)           (13.5)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                   HYDROQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 65     UNCENSORED DEATHS 18     CENSORED DEATHS 10   TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      293   372   406   431   469   495   540   558   583   596                 |
 |      631   637   652   664   676   691   693   696                             |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 50 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 65     UNCENSORED DEATHS 16     CENSORED DEATHS 10   TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      409   440   534   561   606   616   630   640   660   668                 |
 |      668   680   683   717   721   729                                         |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 65     UNCENSORED DEATHS 15     CENSORED DEATHS 14   TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      136   389   548   561   622   641   644   652   656   672                 |
 |      686   700   702   721   729                                               |
 |  CENSORED DEATHS                                                               |
 |      14    15    15    15    457   457   457   457   457   457                 |
 |      457   457   457   457                                                     |
 |                                                                                |
 ==================================================================================

                                   HYDROQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0  98.5  95.4  92.0  88.3  82.8  75.4  68.1      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |50 MG/KG   |   100.0 100.0 100.0 100.0  98.5  96.9  95.1  93.3  84.1  71.3      |
 |           |                                                                    |
 |           |                                                                    |
 |100MG/KG   |   100.0  98.4  98.4  98.4  96.7  96.7  96.7  92.8  82.9  71.1      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          50 MG/KG         100MG/KG      |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       68.1%            71.3%            71.1%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.638N         P=0.690N         P=0.714N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       560.2            622.6            603.9         |
 |NATURAL DEATHS (C)      |       (29.1)           (23.6)           (40.1)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       643.8            664.6            617.7         |
 |(STANDARD ERROR)        |       (15.8)           (13.7)           (24.8)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                            HYDROQUINONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        50 MG/KG         = 2
                                                        100MG/KG         = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                  2                 1
      |                                    2                 1 1  2                 3
      |                                                        1  2      1   2
      |                                                                             3       3
   95 +                                                                  1 1 2    2         3    3
      |                                                                    1      2 2        1
      |                                                                                      1  13 3
      |                                                                             2          2   3       3
P  90 +                                                                                        21      21
E     |                                                                                                    33
R     |                                                                                                2      2
C     |                                                                                                 1  13322
E  85 +                                                                                                    11
N     |                                                                                                      33
T     |                                                                                                     1 13
      |
S  80 +
U     |                                                                                                       12 1
R     |                                                                                                          1  1
V     |                                                                                                          2  2
I  75 +                                                                                                          3  22
V     |
A     |
L     |                                                                                                              2 2
   70 +                                                                                                             11
      |                                                                                                             33 2    2
      |                                                                                                              11
      |                                                                                                               3     3
   65 +                                                                                                               11
      |
      |                                                                                                                11
      |                                                                                                                 1   1
   60 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 11 obs hidden.

                                                            HYDROQUINONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        50 MG/KG         = 2
                                                        100MG/KG         = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                     3                       1                  2
      |                       3                       1            1  3  2   2
      |                                                            1    1    2               2
      |                                                               3                        3
   95 +                                                                 1   1                2 3 2
      |                                                                     1     1              2      2
P     |                                                                           1   1          3        3
E     |                                                                                                 223  3
R  90 +                                                                               1       1          2 2
C     |                                                                                       1 1
E     |                                                                                                    2 2
N     |                                                                                         1   1        2 3 2
T  85 +                                                                                             1  1
      |                                                                                                          22
S     |                                                                                                1    1  3  3
U     |                                                                                                           3 3
R  80 +                                                                                                           2 2
V     |                                                                                                     1  1    3 3
I     |                                                                                                        1 1    33
V     |                                                                                                             2    2
A  75 +                                                                                                          1 1   3 3
L     |                                                                                                            1 1   2  2
      |                                                                                                                  3  3
      |                                                                                                                     2
   70 +                                                                                                              11
      |
      |                                                                                                               1     1
      |
   65 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 5 obs hidden.

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