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TDMS Study 05043-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE


NTP Experiment-Test: 05043-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 19:00:01




       Facility:  TSI Mason Research

       Chemical CAS #:  137-09-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05043-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 19:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      .019 G/      .038 /G                                                
                                                   72VF         KG 72LF      KG 72HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          11           12           20                                                  
    Dead                                               5            7            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           31           28                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (43)         (10)         (45)                                                
   Intestine Large, Cecum                             (49)         (11)         (50)                                                
   Intestine Small, Ileum                             (49)         (11)         (49)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hemangioma                                                    1 (2%)                                                          
      Hepatocellular Carcinoma                         1 (2%)       4 (8%)                                                          
      Hepatocellular Adenoma                           3 (6%)       3 (6%)       3 (6%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Mesentery                                          (7)          (4)          (4)                                                 
      Histiocytic Sarcoma                                           1 (25%)                                                         
   Pancreas                                           (50)         (14)         (49)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Salivary Glands                                    (49)         (11)         (49)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (20)         (50)                                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)       2 (10%)      3 (6%)                                             
   Stomach, Glandular                                 (49)         (15)         (50)                                                
      Squamous Cell Carcinoma, Deep Invasion           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (12)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05043-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 19:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      .019 G/      .038 /G                                                
                                                   72VF         KG 72LF      KG 72HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (14)         (50)                                                
   Adrenal Gland, Medulla                             (46)         (12)         (44)                                                
      Pheochromocytoma Benign                                       1 (8%)                                                          
   Pituitary Gland                                    (46)         (13)         (44)                                                
      Pars Distalis, Adenoma                           7 (15%)      3 (23%)      4 (9%)                                             
   Thyroid Gland                                      (50)         (13)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)                                                              
      Fibrosarcoma                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (48)         (25)         (44)                                                
      Cystadenoma, Papillary                           1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Luteoma                                                       1 (4%)       1 (2%)                                             
      Teratoma                                                      1 (4%)                                                          
   Uterus                                             (50)         (26)         (49)                                                
      Hemangioma                                                                 1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Endometrium, Polyp Stromal                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (12)         (50)                                                
   Lymph Node                                         (47)         (27)         (49)                                                
      Axillary, Histiocytic Sarcoma                    1 (2%)                                                                       
      Inguinal, Histiocytic Sarcoma                    1 (2%)                                                                       
      Lumbar, Histiocytic Sarcoma                      1 (2%)       1 (4%)                                                          
      Mandibular, Histiocytic Sarcoma                  1 (2%)                                                                       
      Mediastinal, Histiocytic Sarcoma                 1 (2%)                                                                       
      Renal, Histiocytic Sarcoma                       1 (2%)       1 (4%)                                                          
   Lymph Node, Mesenteric                             (46)         (23)         (46)                                                
      Histiocytic Sarcoma                              1 (2%)       1 (4%)                                                          
   Spleen                                             (50)         (24)         (50)                                                
      Hemangiosarcoma                                               1 (4%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (33)         (10)         (39)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05043-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 19:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      .019 G/      .038 /G                                                
                                                   72VF         KG 72LF      KG 72HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (36)         (10)         (37)                                                
      Carcinoma                                        1 (3%)       2 (20%)                                                         
   Skin                                               (50)         (31)         (49)                                                
      Fibrosarcoma                                                  1 (3%)       1 (2%)                                             
      Fibrosarcoma, Multiple                                        1 (3%)                                                          
      Subcutaneous Tissue, Sarcoma                                  1 (3%)                                                          
      Vulva, Squamous Cell Carcinoma, Noninvasive                   1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (3)          (1)                                                              
      Head, Sarcoma                                    1 (33%)                                                                      
      Hindlimb, Rhabdomyoma                            1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (20)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (5%)       3 (6%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       4 (20%)                                                         
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Mediastinum, Hemangioma                                                    1 (2%)                                             
   Nose                                               (45)         (11)         (46)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (1)          (1)                                                 
      Adenoma                                          1 (50%)      1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (39)         (50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Renal Tubule, Carcinoma                                       1 (3%)                                                          
   Urinary Bladder                                    (47)         (10)         (47)                                                
                                                             Page   4                                                               
NTP Experiment-Test: 05043-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 19:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      .019 G/      .038 /G                                                
                                                   72VF         KG 72LF      KG 72HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Lymphoma Malignant Histiocytic                                3 (6%)                                                          
      Lymphoma Malignant Lymphocytic                   5 (10%)      2 (4%)       1 (2%)                                             
      Lymphoma Malignant Mixed                         4 (8%)       4 (8%)       5 (10%)                                            
      Lymphoma Malignant Undifferentiated Cell         3 (6%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05043-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 19:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      .019 G/      .038 /G                                                
                                                   72VF         KG 72LF      KG 72HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            24          29          17                                                   
     Total Primary Neoplasms                           34          41          26                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 14          12          13                                                   
     Total Benign Neoplasms                            15          14          18                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              15          21           8                                                   
     Total Malignant Neoplasms                         19          27           8                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05043-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 19:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      .019 G/      .038 G/                                                
                                                   72VM         KG 72LM      KG 72HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           11           12                                                  
    Dead                                               6            6            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           33           36                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (14)         (44)                                                
   Intestine Small, Duodenum                          (47)         (49)         (48)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Intestine Small, Ileum                             (45)         (13)         (48)                                                
   Intestine Small, Jejunum                           (46)         (14)         (48)                                                
   Liver                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                                            1 (2%)                                             
      Hemangiosarcoma, Metastatic                      1 (2%)                                                                       
      Hepatocellular Carcinoma                         5 (10%)      5 (10%)      3 (6%)                                             
      Hepatocellular Carcinoma, Multiple                            1 (2%)                                                          
      Hepatocellular Adenoma                          11 (22%)     14 (28%)      5 (10%)                                            
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Mesentery                                          (3)          (3)                                                              
   Pancreas                                           (50)         (16)         (50)                                                
   Stomach, Forestomach                               (50)         (23)         (50)                                                
      Squamous Cell Papilloma                          2 (4%)       1 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (15)         (50)                                                
      Carcinoma, Metastatic, Uncertain Primary Site                              1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (15)         (49)                                                
      Pheochromocytoma Benign                          2 (4%)                    2 (4%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05043-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 19:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      .019 G/      .038 G/                                                
                                                   72VM         KG 72LM      KG 72HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (49)         (15)         (49)                                                
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Testes                                             (50)         (16)         (50)                                                
      Interstitial Cell, Adenoma                                                 2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (15)         (50)                                                
      Hemangiosarcoma, Metastatic                                   1 (7%)                                                          
   Lymph Node                                         (44)         (36)         (49)                                                
      Mandibular, Carcinoma, Metastatic, Harderian                                                                                  
          Gland                                                     1 (3%)                                                          
      Mediastinal, Histiocytic Sarcoma                 1 (2%)                                                                       
   Lymph Node, Mesenteric                             (44)         (32)         (49)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (50)         (19)         (50)                                                
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                  2 (4%)       1 (5%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (29)         (11)         (31)                                                
      Thymoma Benign                                   1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (29)         (50)                                                
      Carcinoma, Metastatic, Uncertain Primary Site                              1 (2%)                                             
      Fibrosarcoma                                     1 (2%)       3 (10%)      4 (8%)                                             
      Fibrosarcoma, Multiple                           1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma, Poorly                                                                                          
          Differentiated                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05043-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 19:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      .019 G/      .038 G/                                                
                                                   72VM         KG 72LM      KG 72HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)          (1)                                                 
      Hemangiosarcoma                                                            1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (19)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)       2 (11%)      7 (14%)                                            
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (5%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (5%)                                                          
      Carcinoma, Metastatic, Harderian Gland           1 (2%)       1 (5%)                                                          
      Carcinoma, Metastatic, Uncertain Primary Site                              1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Schwannoma Malignant                                                       1 (100%)                                           
   Harderian Gland                                    (2)          (1)          (1)                                                 
      Adenoma                                          1 (50%)                   1 (100%)                                           
      Carcinoma                                        1 (50%)      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (48)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
      Renal Tubule, Adenoma                                                      3 (6%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Lymphoma Malignant Lymphocytic                   3 (6%)       2 (4%)       3 (6%)                                             
      Lymphoma Malignant Mixed                         1 (2%)       1 (2%)                                                          
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05043-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 19:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      .019 G/      .038 G/                                                
                                                   72VM         KG 72LM      KG 72HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Undifferentiated Cell         1 (2%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page  10                                                               
NTP Experiment-Test: 05043-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 19:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      .019 G/      .038 G/                                                
                                                   72VM         KG 72LM      KG 72HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            30          27          31                                                   
     Total Primary Neoplasms                           41          35          39                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 17          15          20                                                   
     Total Benign Neoplasms                            21          18          23                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          15          16                                                   
     Total Malignant Neoplasms                         20          17          16                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           2           3                                                   
     Total Metastatic Neoplasm                          5           4           5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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