National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1269

TDMS Study 05043-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE


NTP Experiment-Test: 05043-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 17:45:27




       Facility:  TSI Mason Research

       Chemical CAS #:  137-09-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05043-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .0125 G/     .025G/KG                                               
                                                   72VF         KG 72LF       72HF                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          13           12           16                                                  
    Dead                                               7            6            2                                                  
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           32           31                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (9)          (14)         (9)                                                 
      Adenocarcinoma                                   1 (11%)                                                                      
   Intestine Large, Rectum                            (8)          (11)         (7)                                                 
   Liver                                              (50)         (30)         (50)                                                
   Mesentery                                          (6)          (5)          (4)                                                 
      Hemangiosarcoma                                  1 (17%)                                                                      
   Pancreas                                           (49)         (13)         (50)                                                
      Acinus, Adenoma                                               1 (8%)                                                          
   Stomach, Forestomach                               (50)         (14)         (50)                                                
   Stomach, Glandular                                 (48)         (13)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (13)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (15)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Medulla, Osteosarcoma, Metastatic, Uncertain                                                                                  
          Primary Site                                 1 (2%)                                                                       
   Adrenal Gland, Medulla                             (47)         (15)         (48)                                                
      Pheochromocytoma Benign                          2 (4%)       1 (7%)       3 (6%)                                             
   Islets, Pancreatic                                 (49)         (14)         (50)                                                
      Adenoma                                                       1 (7%)                                                          
      Carcinoma                                                     1 (7%)                                                          
   Pituitary Gland                                    (50)         (50)         (50)                                                
      Pars Distalis, Adenoma                          22 (44%)     26 (52%)     25 (50%)                                            
                                                             Page   2                                                               
NTP Experiment-Test: 05043-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .0125 G/     .025G/KG                                               
                                                   72VF         KG 72LF       72HF                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Carcinoma                         2 (4%)                    3 (6%)                                             
   Thyroid Gland                                      (50)         (12)         (50)                                                
      Bilateral, C-Cell, Adenoma                                                 1 (2%)                                             
      C-Cell, Adenoma                                  7 (14%)                   6 (12%)                                            
      C-Cell, Carcinoma                                2 (4%)       1 (8%)       3 (6%)                                             
      Follicular Cell, Adenoma                                                   2 (4%)                                             
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (12)         (17)         (9)                                                 
      Adenoma                                          1 (8%)       1 (6%)       1 (11%)                                            
      Adenoma, Moderate                                1 (8%)                                                                       
      Carcinoma                                        1 (8%)       5 (29%)      1 (11%)                                            
   Ovary                                              (49)         (15)         (49)                                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
   Uterus                                             (50)         (15)         (50)                                                
      Polyp Stromal                                   12 (24%)      4 (27%)      9 (18%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (49)         (49)         (50)                                                
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                1 (2%)                                                                       
   Lymph Node, Mandibular                             (44)         (10)         (46)                                                
   Lymph Node, Mesenteric                             (49)         (49)         (50)                                                
   Spleen                                             (50)         (20)         (50)                                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
   Thymus                                             (7)          (11)         (8)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (27)         (29)         (19)                                                
      Carcinoma                                        3 (11%)                                                                      
      Fibroadenoma                                    12 (44%)     16 (55%)     11 (58%)                                            
      Fibroadenoma, Multiple                           5 (19%)      5 (17%)      2 (11%)                                            
   Skin                                               (12)         (13)         (9)                                                 
                                                             Page   3                                                               
NTP Experiment-Test: 05043-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .0125 G/     .025G/KG                                               
                                                   72VF         KG 72LF       72HF                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Basal Cell Adenoma                                                         1 (11%)                                            
      Sebaceous Gland, Adenoma                                                   1 (11%)                                            
      Subcutaneous Tissue, Fibroma                     1 (8%)       1 (8%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                3 (25%)                                                                      
      Subcutaneous Tissue, Sarcoma, Multiple                        1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)                                                 
      Abdominal, Sarcoma                                                         1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (50)                                                
      Carcinoma, Metastatic                                                      2 (4%)                                             
      Cerebrum, Carcinoma, Deep Invasion,                                                                                           
          Metastatic, Pituitary Gland                  1 (2%)                                                                       
      Pons, Glioma NOS                                              1 (9%)                                                          
   Spinal Cord                                                     (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (17)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (6%)                                                          
      Carcinoma, Metastatic, Thyroid Gland                          1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
   Urinary Bladder                                    (49)         (49)         (50)                                                
      Papilloma                                                     1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            13 (26%)      7 (14%)     11 (22%)                                            
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05043-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .0125 G/     .025G/KG                                               
                                                   72VF         KG 72LF       72HF                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Mesothelioma Malignant                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 05043-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .0125 G/     .025G/KG                                               
                                                   72VF         KG 72LF       72HF                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          41          47                                                   
     Total Primary Neoplasms                           91          74          83                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 32          38          39                                                   
     Total Benign Neoplasms                            65          58          62                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          13          19                                                   
     Total Malignant Neoplasms                         26          15          21                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           1           2                                                   
     Total Metastatic Neoplasm                          5           1           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05043-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .0125 G/     .025G/KG                                               
                                                   72 VM        KG 72LM      72HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                  9           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          15           11           19                                                  
    Dead                                              12           16           15                                                  
    Accident                                                        1                                                               
    Gavage Death                                                    1                                                               
  Survivors                                                                                                                         
    Dead                                               1                                                                            
    Terminal Sacrifice                                23           20           16                                                  
    Terminal Sacrifice                                              1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (11)         (19)         (21)                                                
      Serosa, Sarcoma, Metastatic                                                1 (5%)                                             
   Intestine Small, Duodenum                          (47)         (50)         (50)                                                
   Liver                                              (50)         (31)         (50)                                                
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Mesentery                                          (7)          (8)          (4)                                                 
   Pancreas                                           (50)         (22)         (50)                                                
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
      Acinus, Adenoma                                  1 (2%)                    3 (6%)                                             
      Acinus, Adenoma, Multiple                                     1 (5%)                                                          
   Stomach, Forestomach                               (49)         (23)         (50)                                                
   Stomach, Glandular                                 (49)         (23)         (50)                                                
   Tongue                                                                       (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (22)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
   Adrenal Gland, Medulla                             (49)         (50)         (50)                                                
      Pheochromocytoma Malignant                       7 (14%)      2 (4%)       3 (6%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05043-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .0125 G/     .025G/KG                                               
                                                   72 VM        KG 72LM      72HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign                          8 (16%)      7 (14%)      7 (14%)                                            
      Bilateral, Pheochromocytoma Benign               2 (4%)       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (22)         (50)                                                
      Adenoma                                          3 (6%)       3 (14%)      2 (4%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (50)         (50)         (49)                                                
      Pars Distalis, Adenoma                          23 (46%)     17 (34%)     14 (29%)                                            
      Pars Distalis, Carcinoma                         1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (20)         (50)                                                
      Bilateral, C-Cell, Carcinoma                     1 (2%)                                                                       
      C-Cell, Adenoma                                  4 (8%)       4 (20%)      2 (4%)                                             
      C-Cell, Adenoma, Mild                                                      1 (2%)                                             
      C-Cell, Carcinoma                                1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (20)         (50)                                                
      Serosa, Sarcoma, Metastatic, Uncertain                                                                                        
          Primary Site                                                           1 (2%)                                             
   Preputial Gland                                    (17)         (24)         (26)                                                
      Adenoma                                          1 (6%)       2 (8%)       2 (8%)                                             
      Carcinoma                                        2 (12%)      3 (13%)      2 (8%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (4%)                                             
   Prostate                                           (49)         (19)         (50)                                                
      Adenoma                                          2 (4%)                    1 (2%)                                             
   Seminal Vesicle                                    (50)         (25)         (50)                                                
   Testes                                             (50)         (50)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           25 (50%)     25 (50%)     35 (70%)                                            
      Interstitial Cell, Adenoma                      17 (34%)     17 (34%)     11 (22%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (11)         (20)         (21)                                                
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (5%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
   Lymph Node, Mandibular                             (49)         (14)         (47)                                                
   Lymph Node, Mesenteric                             (49)         (49)         (50)                                                
   Spleen                                             (50)         (29)         (50)                                                
      Hemangiosarcoma                                               1 (3%)                                                          
      Sarcoma                                          1 (2%)       2 (7%)       1 (2%)                                             
                                                             Page   8                                                               
NTP Experiment-Test: 05043-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .0125 G/     .025G/KG                                               
                                                   72 VM        KG 72LM      72HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
      Sarcoma, Poorly Differentiated                   1 (2%)                                                                       
   Thymus                                             (17)         (17)         (24)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (9)          (10)         (12)                                                
      Fibroadenoma                                     4 (44%)                                                                      
   Skin                                               (20)         (26)         (28)                                                
      Basal Cell Adenoma                               1 (5%)       1 (4%)       1 (4%)                                             
      Keratoacanthoma                                  2 (10%)                   3 (11%)                                            
      Keratoacanthoma, Multiple                                                  1 (4%)                                             
      Squamous Cell Carcinoma                          1 (5%)                    1 (4%)                                             
      Squamous Cell Papilloma                                       1 (4%)       1 (4%)                                             
      Trichoepithelioma                                             1 (4%)                                                          
      Sebaceous Gland, Carcinoma                       1 (5%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (5%)                    1 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (5%)       1 (4%)       1 (4%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (5%)                                                                       
      Subcutaneous Tissue, Sarcoma, Metastatic,                                                                                     
           Uncertain Primary Site                                                1 (4%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                                  1 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (2)                                                 
      Abdominal, Sarcoma                                                         1 (50%)                                            
      Hindlimb, Sarcoma, Metastatic, Uncertain                                                                                      
          Primary Site                                                           1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (20)         (50)                                                
      Astrocytoma Malignant                                                      1 (2%)                                             
      Glioma NOS                                                    1 (5%)                                                          
      Granular Cell Tumor Benign                                                 1 (2%)                                             
      Squamous Cell Carcinoma, Early Invasion,                                                                                      
           Metastatic, Zymbal's Gland                               1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05043-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .0125 G/     .025G/KG                                               
                                                   72 VM        KG 72LM      72HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (30)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    3 (6%)                                             
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                             1 (3%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Nose                                               (12)         (21)         (21)                                                
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (5%)                                             
      Nares, Squamous Cell Papilloma                                1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (1)          (2)                                                 
      Carcinoma                                        1 (100%)     1 (100%)     1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)                                                
      Sarcoma, Metastatic                                                        1 (2%)                                             
      Renal Tubule, Adenoma                                                      1 (2%)                                             
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
      Transitional Epithelium, Carcinoma                                         1 (2%)                                             
   Urinary Bladder                                    (50)         (48)         (50)                                                
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                             7 (14%)      4 (8%)       5 (10%)                                            
      Mesothelioma Malignant                           2 (4%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05043-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .0125 G/     .025G/KG                                               
                                                   72 VM        KG 72LM      72HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          46          49                                                   
     Total Primary Neoplasms                          126         100         112                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          45          48                                                   
     Total Benign Neoplasms                            96          81          91                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          16          18                                                   
     Total Malignant Neoplasms                         30          18          21                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2           2                                                   
     Total Metastatic Neoplasm                                      2          13                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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