National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1273

TDMS Study 05043-01 Pathology Tables

NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97
Route: GAVAGE                                                                                                     Time: 09:17:22




       Facility:  TSI Mason Research

       Chemical CAS #:  137-09-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|             
                                           | 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |          X  X  X        X  X  X     X  X  X     X  X        X  X  X      |             
      Clear Cell Focus                     |          X  X                                                            |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         | 4              2     3     3     2  1  1           3                     |             
      Granuloma                            |          3                                                               |             
      Hepatodiaphragmatic Nodule           |    X     X                             X                                 |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                               2  2                                       |             
      Mixed Cell Focus                     |                                                 X                        |             
      Bile Duct, Hyperplasia               | 3        3  2           1        2  1  1  1        3           1     1   |             
      Centrilobular, Inflammation, Acute   |                                                          3               |             
      Centrilobular, Necrosis              |                3                                                         |             
      Midzonal, Necrosis                   |                                                                          |             
      Sinusoid, Embolus Bacterial          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +        +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                   3  3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                           2        1                     |             
      Acinus, Hyperplasia, Focal           |                               2                                          |             
      Serosa, Neovascularization, Diffuse  |                                                          3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +                 +     +  +        +                 +           +  +|             
      Embolus Bacterial                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Ulcer                                |                            2                                            2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  M  +     +  +  +  +  +  M  +  +     +  +     +  +  +  +  +  +|             
      Embolus Bacterial                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1                       1  2                             1     1      |             
      Interstitium, Embolus Bacterial      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|             
                                           | 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Degeneration                         | 3                                      3        2        2     2         |             
      Embolus Bacterial                    |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                             2            |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     M  +  +     +  +  +  +  M  +  +  +     +  +     +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                           2                    2     2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +     +  +  +     +  +  +  +     +  +     +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  M  +     M  M  +  +  +  +  M  M     M  +     M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
      Pars Distalis, Angiectasis           |                                                                3         |             
      Pars Distalis, Cyst                  |                                                                X     X   |             
      Pars Distalis, Embolus Bacterial     |                                                                          |             
      Pars Distalis, Hemorrhage            | 2                                         3                              |             
      Pars Distalis, Hyperplasia, Focal    |                                                                         1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Embolus Bacterial                    |                                                                          |             
      C-Cell, Hyperplasia                  |    3     1                                      1  2        2     3      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                      +     +                    +        +  +           +|             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +     +  +  +  +  M  +  +  +     +  +     +  +  +  +  +  +|             
      Cyst                                 |                                                                   X      |             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                      +                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Cervix, Hyperplasia, Cystic          |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                     +                                    |             
      Inflammation, Suppurative            |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|             
                                           | 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pancreatic, Pigmentation             |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +     +  +  +  +  +  M  +  +     +  +     +  +  +  +  +  +|             
      Congestion                           |             3                                                            |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Pigmentation, Hemosiderin            |                                           2        2                     |             
      Pigmentation                         |    2           2        2     1  2  3  2        1           2  2  2  1  2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Embolus Bacterial                    |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                          3  2            |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Thrombosis                           | X                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  |                      +     +                             +              M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +           +     +  +  +  +  +  +           +        +  +     +  +  +|             
      Hyperplasia, Cystic                  |                            3     4                                       |             
      Hyperplasia                          |                         4                                   2            |             
                                            __________________________________________________________________________|             
   Skin                                    |                      +     +                             +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                      +     +                             +              +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Embolus Bacterial                    |                                                                          |             
      Cerebrum, Perivascular, Inflammation |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Adenomatosis                         |                                     2                                   2|             
      Congestion                           |                3                    2  3                                 |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic, Focal         |                            2                                             |             
      Inflammation, Granulomatous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|             
                                           | 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                             2            |             
      Capillary, Embolus Bacterial         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                      +     +                             +              +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                 +                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                 +  +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Congestion                           |                3                                                         |             
      Nephropathy                          | 2  2     1  2              4  3  2  3     2     1  1        1     1  1  4|             
      Capillary, Embolus Bacterial         |                                                                          |             
      Cortex, Cyst                         |                            X                                      X      |             
      Renal Tubule, Hyperplasia, Focal     |                                                                         1|             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |             3                                                            |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Inflammation, Chronic                |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|             
                                           | 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  M  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                                            A     +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                                            A     +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                                            A     +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +                                            A     +         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                                            A     +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +                                            A     +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     | X  X     X     X  X     X  X     X  X  X  X  X  X  X  X     X  X  X  X   |             
      Clear Cell Focus                     | X                                                                        |             
      Eosinophilic Focus                   |                                     2                                    |             
      Fatty Change                         |    1                       2                 3        2        2        4|             
      Granuloma                            |                                                                          |             
      Hepatodiaphragmatic Nodule           |          X                             X                                 |             
      Inflammation, Chronic                |             2                                                        2   |             
      Inflammation, Granulomatous          |          2                                                               |             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               |          1     1  1     2        3  4     1  2  2     2     1     2      |             
      Centrilobular, Inflammation, Acute   |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Midzonal, Necrosis                   |                                                          4               |             
      Sinusoid, Embolus Bacterial          |                                                          3               |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis, Focal                 |          3                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Acinus, Atrophy                      |          4                                      4                    2   |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Serosa, Neovascularization, Diffuse  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +  +                 +  +  +                 +  +  +  +      |             
      Embolus Bacterial                    |                                                          3               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus Bacterial                    |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1                       1        1     3     1  2  1                  |             
      Interstitium, Embolus Bacterial      |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|             
                                           | 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         | 3                 2     3                       3           2           4|             
      Embolus Bacterial                    |                                                          3               |             
      Hyperplasia, Focal                   |                                        3                    1            |             
      Hyperplasia                          |          2                                                               |             
      Necrosis                             |                                                                         3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                2                                   2                 3   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             4            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  M  +     +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                        X                                 |             
      Pars Distalis, Embolus Bacterial     |                                                          2               |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                1                                            2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus Bacterial                    |                                                          3               |             
      C-Cell, Hyperplasia                  |    3                                         1     1                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                          +               |             
      Necrosis                             |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |             +                                            +     +         |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Follicle, Cyst                       |                X                                                         |             
                                            __________________________________________________________________________|             
   Oviduct                                 |             +                                                  +         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Hyperplasia, Cystic          |                                                       3                  |             
      Endometrium, Hyperplasia, Cystic     |                                     4                                    |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|             
                                           | 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                                            A     +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Mediastinal, Congestion              |                                           3                              |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                4                          3                              |             
      Pancreatic, Pigmentation             |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  M  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                         4                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Congestion                           |             3                                                            |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pigmentation                         |    1              2     2  1     1     1  2     2  2  2     2     1  2  2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus Bacterial                    |                                                          3               |             
      Fibrosis                             |                                     3                                    |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                                                          4               |             
      Pigmentation, Hemosiderin            |                                           4                          4   |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +                                            A     +         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +        +                    +  +        +           +     +  +  +   |             
      Hyperplasia, Cystic                  |                                                                   4      |             
      Hyperplasia                          |             3                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    |             +                                            +  +  +         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +                                            +     +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus Bacterial                    |                                                          3               |             
      Cerebrum, Perivascular, Inflammation |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |                                                                          |             
      Congestion                           |                                           3                    4         |             
      Inflammation, Acute                  |                   1                                                      |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|             
                                           | 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Capillary, Embolus Bacterial         |                                                          3               |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                                            +     +         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |             2                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Nephropathy                          |    2     1  2  1  2     2  4                 2  2  2  2                  |             
      Capillary, Embolus Bacterial         |                                                          4               |             
      Cortex, Cyst                         |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                          +               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 4| 7| 7| 4| 2| 4| 7|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3|                                            |            |
                                           | 9| 6| 6| 0| 6| 6| 2| 6| 2| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +     +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +                 +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                    +                                                   |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                 +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                    +                                                   |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +     +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +     +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                    +                                                   |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                    +                                                   |   8        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +     +     +                                             |  50        |
      Angiectasis, Focal                   |                2                                                         |      1  2.0|
      Basophilic Focus                     |       X        X           X                                             |     36     |
      Clear Cell Focus                     |                                                                          |      3     |
      Eosinophilic Focus                   |                                                                          |      1  2.0|
      Fatty Change                         |                                                                          |     14  2.4|
      Granuloma                            |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      5     |
      Inflammation, Chronic                |    2                                                                     |      3  2.0|
      Inflammation, Granulomatous          |             1                                                            |      4  1.8|
      Mixed Cell Focus                     |                                                                          |      1     |
      Bile Duct, Hyperplasia               |       1        2                                                         |     25  1.8|
      Centrilobular, Inflammation, Acute   |                                                                          |      1  3.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Midzonal, Necrosis                   |                                                                          |      1  4.0|
      Sinusoid, Embolus Bacterial          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                 +                                                   |   6        |
      Inflammation, Chronic                |    3                                                                     |      1  3.0|
      Fat, Necrosis, Focal                 |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +     +     +                                             |  49        |
      Acinus, Atrophy                      |                                                                          |      5  2.6|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  2.0|
      Serosa, Neovascularization, Diffuse  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +           +        +                                                   |  21        |
      Embolus Bacterial                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +     +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +     +     +                                             |  50        |
      Ulcer                                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +     +     +                                             |  48        |
      Embolus Bacterial                    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 4| 7| 7| 4| 2| 4| 7|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3|                                            |            |
                                           | 9| 6| 6| 0| 6| 6| 2| 6| 2| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +     +     +                                             |  50        |
      Cardiomyopathy                       |    1                       1                                             |     16  1.3|
      Interstitium, Embolus Bacterial      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +     +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +     +     +                                             |  50        |
      Degeneration                         |             2                                                            |     12  2.6|
      Embolus Bacterial                    |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |    2                                                                     |      3  2.0|
      Hyperplasia                          |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +        +     +                                             |  47        |
      Hyperplasia, Focal                   |                                                                          |      3  2.3|
      Hyperplasia                          |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +     +     +                                             |  49        |
      Hyperplasia                          |             2                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +     M  +     +     +                                             |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +     +     +                                             |  50        |
      Cyst                                 |       X                                                                  |      3     |
      Pars Distalis, Angiectasis           |                2                                                         |      2  2.5|
      Pars Distalis, Cyst                  |                                                                          |      3     |
      Pars Distalis, Embolus Bacterial     |                                                                          |      1  2.0|
      Pars Distalis, Hemorrhage            |                                                                          |      2  2.5|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +     +     +                                             |  50        |
      Embolus Bacterial                    |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  |    3                                                                     |     10  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +                 +                                                   |  12        |
      Inflammation, Suppurative            |    3                                                                     |      1  3.0|
      Duct, Cyst                           |    X                                                                     |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 4| 7| 7| 4| 2| 4| 7|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3|                                            |            |
                                           | 9| 6| 6| 0| 6| 6| 2| 6| 2| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +     +     +                                             |  49        |
      Cyst                                 |                                                                          |      1     |
      Follicle, Cyst                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +     +     +                                             |  50        |
      Cervix, Hyperplasia, Cystic          |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |       3                                                                  |      2  3.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                    +                                                   |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +     +     +                                             |  49        |
      Mediastinal, Congestion              |                                                                          |      1  3.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                3                                                         |      3  3.3|
      Pancreatic, Pigmentation             |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +     M  M     +     +                                             |  44        |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +     +     +                                             |  49        |
      Congestion                           |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      2  2.0|
      Pigmentation                         |    2  2     3  2           2                                             |     32  1.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +     +     +                                             |  50        |
      Embolus Bacterial                    |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Necrosis                             |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                                                                          |      2  4.0|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                    +                                                   |   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                    +     +                                             |  27        |
      Hyperplasia, Cystic                  |                            4                                             |      4  3.8|
      Hyperplasia                          |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                    +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 4| 7| 7| 4| 2| 4| 7|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3|                                            |            |
                                           | 9| 6| 6| 0| 6| 6| 2| 6| 2| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                    +                                                   |   9        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +     +     +                                             |  50        |
      Embolus Bacterial                    |                                                                          |      1  3.0|
      Cerebrum, Perivascular, Inflammation |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +     +     +                                             |  50        |
      Adenomatosis                         |                                                                          |      2  2.0|
      Congestion                           |                                                                          |      5  3.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |             1                                                            |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Capillary, Embolus Bacterial         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                    +                                                   |   9        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +     +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +     +     +                                             |  50        |
      Congestion                           |                                                                          |      1  3.0|
      Nephropathy                          |    2  1     3  2           2                                             |     31  2.0|
      Capillary, Embolus Bacterial         |                                                                          |      1  4.0|
      Cortex, Cyst                         |                                                                          |      2     |
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 4| 7| 7| 4| 2| 4| 7|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3|                                            |            |
                                           | 9| 6| 6| 0| 6| 6| 2| 6| 2| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +     +     +                                             |  49        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4| 4| 7| 6| 5| 4| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 5| 5| 2| 5| 0| 9| 4| 8| 3| 3| 1| 5| 4|             
                                           | 1| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 3| 0| 2| 2| 4| 4| 0| 0| 2| 2| 4| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .0125 G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +                             +           +  +              M|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                             +           +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                             +           +  +        +     +|             
      Mucosa, Pigmentation                 |                                                                   4      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +                             +           +  +              +|             
      Parasite Metazoan                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
      Lamina Propria, Pigmentation         | 4  4  4  4  4  4  3  4  4     4  4  3     3     3  3  4  4  4  4  4     4|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Liver                                   |       +     +                 +  +  +     +     +  +  +  +     +  +     +|             
      Basophilic Focus                     |       X                          X        X     X  X     X     X        X|             
      Congestion                           |             4                             2                              |             
      Fatty Change                         |       1     1                    3                             1  4      |             
      Hematopoietic Cell Proliferation     |                                                       1                  |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                  X                                       |             
      Inflammation, Granulomatous          |                                                                3         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Bile Duct, Hyperplasia               |       1                             1                    2        1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Fat, Necrosis, Focal                 |                               4                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Stomach                                 |             +                       +     +           +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +                       +     +           +  +        +     +|             
      Pigmentation                         |                                                                          |             
      Ulcer                                |                                                                   4      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +                       +     +           +  +              +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +                    +        +           +  +              +|             
      Cardiomyopathy                       |             2                                                            |             
      Ventricle, Fibrosis                  |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +     +                             +           +  +              +|             
      Capsule, Degeneration                |       3                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +     +                             +           +  +              +|             
      Congestion                           |                                                                          |             
      Degeneration                         |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4| 4| 7| 6| 5| 4| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 5| 5| 2| 5| 0| 9| 4| 8| 3| 3| 1| 5| 4|             
                                           | 1| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 3| 0| 2| 2| 4| 4| 0| 0| 2| 2| 4| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .0125 G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +     +                             +           +  +              +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +                       +     +           +  +              +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                           X                              |             
      Pars Distalis, Hyperplasia, Focal    |                                                                2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +                             +           +  +              +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |             +                       +     +           +  +              M|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +     +                       +           +  +              +|             
      Follicle, Cyst                       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                           +           +  +              +|             
                                            __________________________________________________________________________|             
   Uterus                                  |    +        +  +                 +        +           +  +              +|             
      Hydrometra                           |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
      Lumbar, Cyst                         |                                                                          |             
      Pancreatic, Pigmentation             | 4  4  4  4     3  3  4  4     4  4  4              4  4  4  4  4  4     4|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             M                             +           M  +              M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
      Congestion                           |                                                                          |             
      Pigmentation                         | 2  3  1  2     2     2        2  2              2     2        4  3      |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +                       +     +     +  +  +  +        +     +|             
      Hematopoietic Cell Proliferation     |                                                    4  4                  |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +                             +           +  M              +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +           M     +  +        +  +  +     +        +  +  +  +  +  +     +|             
      Hyperplasia, Cystic                  |                                                       3                  |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |             +  +                          +           +  +              +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4| 4| 7| 6| 5| 4| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 5| 5| 2| 5| 0| 9| 4| 8| 3| 3| 1| 5| 4|             
                                           | 1| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 3| 0| 2| 2| 4| 4| 0| 0| 2| 2| 4| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .0125 G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +                             +           +  +              +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +  +                          +     +     +  +        +     +|             
      Congestion                           |             3  2                          3     3                        |             
      Hemorrhage, Focal                    |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Trachea                                 |             +                             +           +  +              +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                      +               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
      Inflammation, Chronic                |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
      Nephropathy                          | 1  1  2  1     1  2  1  1     1  1              2  1           2  4      |             
      Papilla, Necrosis, Diffuse           |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                                                 2                        |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 3  3  3  2  3  3  3  3  3     2  2  2     2     3     2  3  3  3  4     3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
      Submucosa, Inflammation,             |                                                                          |             
          Granulomatous                    |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 1| 5| 4| 3| 3| 3| 3| 9|             
                                           | 2| 2| 2| 2| 0| 2| 2| 8| 0| 0| 2| 2| 2| 2| 0| 2| 6| 7| 2| 2| 2| 2| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .0125 G/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +     +                             +     A  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                      +                             A     A               |             
      Mucosa, Pigmentation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +     +                             A     A  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                      +                             +     A               |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lamina Propria, Pigmentation         | 4  3  4        4  4  3        4  4  4  4     4  4  4     2  4  4  4  4  4|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                      +                             A     A               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                      +                             A     +               |             
                                            __________________________________________________________________________|             
   Liver                                   |                +     +              +        +  +  +     +           +   |             
      Basophilic Focus                     |                X                    X        X                       X   |             
      Congestion                           |                                                                          |             
      Fatty Change                         |                1     3                             4     2               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage, Multifocal               |                                              3                           |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Multifocal                 |                                                                      3   |             
      Bile Duct, Hyperplasia               |                                                 2  1                 2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +                                                              +   |             
      Fat, Necrosis, Focal                 |    4  4                                                              4   |             
                                            __________________________________________________________________________|             
   Pancreas                                |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Stomach                                 |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                      +                             +     +               |             
      Pigmentation                         |                                                                          |             
      Ulcer                                |                                                    1                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                      +                             +     +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                      +                             +     +               |             
      Cardiomyopathy                       |                                                    3                     |             
      Ventricle, Fibrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                      +                          +  +     +               |             
      Capsule, Degeneration                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                      +                          +  +     +               |             
      Congestion                           |                                                          3               |             
      Degeneration                         |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 1| 5| 4| 3| 3| 3| 3| 9|             
                                           | 2| 2| 2| 2| 0| 2| 2| 8| 0| 0| 2| 2| 2| 2| 0| 2| 6| 7| 2| 2| 2| 2| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .0125 G/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                      +                          +  +     +               |             
      Congestion                           |                                                          3               |             
      Hyperplasia, Focal                   |                                                 2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                    +                             +     +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                      +                             +     M               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                    2                     |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    1                          2        2                    1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                      +                             +     +               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +     +           +  +                             +     M           +   |             
      Inflammation, Chronic                |                   2                                                      |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +              +                             +     +               |             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                          +               |             
                                            __________________________________________________________________________|             
   Uterus                                  |                      +                             +     +               |             
      Hydrometra                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +        +  +  +  +     +  +  +     +  M  +  +  +  +|             
      Lumbar, Cyst                         |                                                                          |             
      Pancreatic, Pigmentation             |    4           4  4           4  4  4  4     4  3              4  4  4   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +        +  +  +  +     +  +  +     +  M  +  +  +  +|             
      Congestion                           |                                                                          |             
      Pigmentation                         | 2     2        3     3        2  1  3  2     2                       2   |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +     +                          +  +     +           +   |             
      Hematopoietic Cell Proliferation     |                                                                      4   |             
                                            __________________________________________________________________________|             
   Thymus                                  |                      +                          +  +     +               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +        +  +  M                 +     +     +     M     +  +      |             
      Hyperplasia, Cystic                  |                   4                                                      |             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Skin                                    |                      +                             +     +               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 1| 5| 4| 3| 3| 3| 3| 9|             
                                           | 2| 2| 2| 2| 0| 2| 2| 8| 0| 0| 2| 2| 2| 2| 0| 2| 6| 7| 2| 2| 2| 2| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .0125 G/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                      +                             +     +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                    +                             +     +               |             
      Congestion                           |                                                          4               |             
      Hemorrhage, Focal                    | 3                                                                        |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 2                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Trachea                                 |                      +                             +     +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +              +                 +  +  +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Nephropathy                          | 2  1  2        2  2           1  1  2  2     4  1  1        1  2  1  1  2|             
      Papilla, Necrosis, Diffuse           |                                                          4               |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 3  3  3        3  2  2        3  3  3  3     4  3  3        3  3  2  3  4|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Submucosa, Inflammation,             |                                                                          |             
          Granulomatous                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9|                                            |            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 0| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    .0125 G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +        +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +        +  +  +                                             |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +        +  +  +                                             |  11        |
      Mucosa, Pigmentation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +        +  +  +                                             |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +        +  +  +                                             |  11        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lamina Propria, Pigmentation         | 4  4  4  4  3  4  4  3  4  3                                             |     50  3.8|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +        +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +        +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +  +  +  +  +  +                                             |  30        |
      Basophilic Focus                     | X        X  X  X  X     X  X                                             |     19     |
      Congestion                           |                                                                          |      2  3.0|
      Fatty Change                         | 3                    3     2                                             |     12  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hemorrhage, Multifocal               |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           | X                    X                                                   |      3     |
      Inflammation, Granulomatous          | 2                                                                        |      2  2.5|
      Mixed Cell Focus                     |          X                                                               |      1     |
      Necrosis, Multifocal                 |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |          1        1  2                                                   |     10  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   5        |
      Fat, Necrosis, Focal                 | 4                                                                        |      5  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +           +        +  +  +                                             |  13        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +        +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +        +  +  +                                             |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +        +  +  +                                             |  14        |
      Pigmentation                         |                      1                                                   |      1  1.0|
      Ulcer                                |                      4                                                   |      3  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +        +  +  +                                             |  13        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +        +  +  +                                             |  13        |
      Cardiomyopathy                       |                                                                          |      2  2.5|
      Ventricle, Fibrosis                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9|                                            |            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 0| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    .0125 G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +  +        +  +  +                                             |  15        |
      Capsule, Degeneration                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  +        +  +  +                                             |  15        |
      Congestion                           |                                                                          |      1  3.0|
      Degeneration                         |                                                                          |      2  2.5|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +  +        +  +  +                                             |  15        |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +        +  +  +                                             |  14        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +        +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Angiectasis           |       3                    2                                             |      3  2.3|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |    3                 2                                                   |      7  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +        +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +        +  M  +     +  +  +                                             |  17        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |             +        +  +  +                                             |  15        |
      Follicle, Cyst                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |             +              +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |             +        +  +  +                                             |  15        |
      Hydrometra                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +        +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Lumbar, Cyst                         |                X                                                         |      1     |
      Pancreatic, Pigmentation             | 4  4  4  4     4                                                         |     35  3.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  +        +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Congestion                           |                            3                                             |      1  3.0|
      Pigmentation                         | 2                 1     3  2                                             |     26  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9|                                            |            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 0| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    .0125 G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |             +  +     +  +  +                                             |  20        |
      Hematopoietic Cell Proliferation     |                4                                                         |      4  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |             M        +  +  +                                             |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +           +        +  +  +                                             |  29        |
      Hyperplasia, Cystic                  | 4                    2  2                                                |      5  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |             +        +  +  +                                             |  13        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +        +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +        +  M  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                      +                                                   |   1        |
      Hemorrhage                           |                      4                                                   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +     +        +  +  +                                             |  17        |
      Congestion                           |       3     3                                                            |      7  3.0|
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |             +        +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +        +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Nephropathy                          | 3  1  2  2     1  1  1  1                                                |     39  1.6|
      Papilla, Necrosis, Diffuse           |                                                                          |      1  4.0|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 4  3  3  3  3  2  3  3  2  3                                             |     48  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9|                                            |            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 0| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    .0125 G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Submucosa, Inflammation,             |                                                                          |            |
          Granulomatous                    |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|             
                                           | 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +           +           +        +                 +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +           +        +                                +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +           +        +                 +              +     +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +           +        +                                +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lamina Propria, Inflammation, Acute  |                                                                          |             
      Lamina Propria, Pigmentation         | 4  4  4  3  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4     3|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +           +                                         +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +           +                                         +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Basophilic Focus                     | X  X  X        X  X  X  X     X  X  X  X  X  X  X  X     X  X  X        X|             
      Clear Cell Focus                     |       X                                                  X     X         |             
      Fatty Change                         |                         2                                         4      |             
      Hematocyst                           |                                                                X         |             
      Hepatodiaphragmatic Nodule           |          X                    X                          X               |             
      Inflammation, Granulomatous          |    1  2                          2                 2           2         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               |    1     4  3  1  1  1        1  2              1  1  2  1     2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +              +                                                |             
      Inflammation, Chronic                |                         3                                                |             
      Fat, Necrosis, Focal                 |          4                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Acinus, Atrophy                      |                3                             2                           |             
      Acinus, Hyperplasia, Focal           |                               2                                          |             
      Acinus, Hypertrophy, Focal           |                                                                          |             
      Artery, Inflammation, Chronic Active |       4                                                                  |             
      Duct, Cyst                           |                                  X                                       |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +  +        +     +  +  +  +  +  +        +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Acanthosis                           |       4                             2                                    |             
      Pigmentation                         |    2  4                             2                                    |             
      Ulcer                                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Edema                                |                                                                          |             
      Erosion, Focal                       |                         3                                                |             
      Hyperplasia, Focal                   |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|             
                                           | 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Cardiomyopathy                       |    2  3                          2     1  1              2     1        2|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Congestion                           |             3                                                            |             
      Degeneration, Focal                  |                                                                          |             
      Degeneration                         |             3                                2                           |             
      Hyperplasia, Focal                   |                2                                                         |             
      Hyperplasia                          |                                              2                           |             
      Hypertrophy                          |                                                                1         |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                          1               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  M     +  M  M  +  +  +  +  M  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           |                               4                       2                  |             
      Pars Distalis, Cyst                  |                         X                                                |             
      Pars Distalis, Hyperplasia, Focal    |          3                                   2  1                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      C-Cell, Hyperplasia                  |                                                             2            |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                         +                    +                    +     +|             
      Inflammation, Suppurative            |                                              1                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                         +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Endometriosis                        |                                                                          |             
      Hydrometra                           |    2                                                                     |             
      Endometrium, Hyperplasia, Cystic     |    4     3                    3                                          |             
      Lumen, Hemorrhage                    |                                                                          |             
      Wall, Necrosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|             
                                           | 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +           +                                         +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Mediastinal, Congestion              |                         2                                                |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                   3      |             
      Pancreatic, Pigmentation             | 4  4  4  4     4  4  2              4     4     4  4  4  4  4  4  4     3|             
      Renal, Congestion                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Pigmentation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Pigmentation                         | 4  4  4  3  2  4  4  4  3     4  4  4  4  4  4  4  3  4  4  3  4  3      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hematopoietic Cell Proliferation     |                                                                   4      |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +  +           +                                         +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +  +  +     +           +  +  +     +  +              +     +|             
      Hyperplasia, Cystic                  |                                        4                                 |             
                                            __________________________________________________________________________|             
   Skin                                    |             +           +                    +                    +     +|             
      Face, Abscess                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                         +                                         +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Adenomatosis                         |                                                             2            |             
      Congestion                           |                                                                         3|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +           +                                         M     +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                         2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
      Lens, Mineralization                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|             
                                           | 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Nephropathy                          | 2  2  1        3  4  1        2  3  2  2  1  2  1  2     1  3  2         |             
      Renal Tubule, Hyperplasia, Focal     |                2                    1                                    |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 4  3  4  4  4  4  4  4  3     4  4  4  4  4  4  4  4  3  4  3  4  4     4|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|             
                                           | 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .025G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                           +                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                           +                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                           +                              |             
      Parasite Metazoan                    |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                           M                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Lamina Propria, Inflammation, Acute  |                                                    4                     |             
      Lamina Propria, Pigmentation         | 4  4  4        4  4  4  4     4  4  4     1  4  4  3        4  4  3  3  4|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                           +                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                  M        +                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Basophilic Focus                     | X  X  X        X  X     X     X  X  X        X  X           X  X     X  X|             
      Clear Cell Focus                     | X                                                                        |             
      Fatty Change                         |                   3                             2  2              4      |             
      Hematocyst                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X                    X                                    |             
      Inflammation, Granulomatous          |                               1  3           2              1        1   |             
      Mixed Cell Focus                     |                                                             X            |             
      Necrosis, Focal                      |                                  2                                       |             
      Bile Duct, Hyperplasia               | 1  2           2  1  2        2  1  1           1  1        2     1     2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Acinus, Atrophy                      |    1                                1                                    |             
      Acinus, Hyperplasia, Focal           |       3              3                                            2      |             
      Acinus, Hypertrophy, Focal           |                                  2                                       |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Duct, Cyst                           |                                                                          |             
      Duct, Hyperplasia                    |                                  3                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +              +        +     +     +                       +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Acanthosis                           |       2        3                                   3                     |             
      Pigmentation                         |       1        2        2                 1                       1      |             
      Ulcer                                |                      1                                            4      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +  +  +     +  +  +     +  +  M  +        +  +  +  +  +|             
      Edema                                |                                                                   3      |             
      Erosion, Focal                       |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|             
                                           | 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .025G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Cardiomyopathy                       | 2     1           2     1     2                                2         |             
      Inflammation, Chronic                |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Degeneration, Focal                  |                               2                                          |             
      Degeneration                         |                                  4                             4         |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +     +  +  +     +  +  +  M        +  +  +  M  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +  +  +  M     +  +  +     M  +  M  M        +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                X                                                         |             
      Pars Distalis, Hyperplasia, Focal    |                                                                1     3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Hyperplasia         | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                           +  +                       +   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Endometriosis                        |                                                                          |             
      Hydrometra                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                      2   |             
      Lumen, Hemorrhage                    | 3                                                                        |             
      Wall, Necrosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|             
                                           | 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .025G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                           +                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pancreatic, Pigmentation             | 4              4        4     4              4  4  4        4  4  4  4  4|             
      Renal, Congestion                    |                                                                         4|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +           +  +  +     M  +  +     +  +  +  +        +  +  +  +   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Pigmentation                         | 4              4  3  2  3     4  4           4  4  3        4  4  3  4  4|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                      3   |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                      +  +                 M                 +  +         |             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                                     +     +                              |             
      Face, Abscess                        |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                           +                              |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Adenomatosis                         |                                                                          |             
      Congestion                           |                   2                                                      |             
      Interstitium, Inflammation, Chronic  |                                                                   3      |             
                                            __________________________________________________________________________|             
   Nose                                    |                                           +                              |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                            +                        |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Lens, Mineralization                 |    3                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|             
                                           | 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .025G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Nephropathy                          | 2  3  4        3  3  4  1     4  2  3        3  2  4        4  1  3  2  1|             
      Renal Tubule, Hyperplasia, Focal     |                               2                    1              1      |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 4  3  4        4  4  4  4     4  4  4        4  4  3        4  4  3  3  4|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5|                                            |            |
                                           | 1| 1| 1| 3| 0| 1| 1| 6| 8| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                      +  +                                                |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                      +  +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                      +  +                                                |   9        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                      +  +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +                                                |  50        |
      Lamina Propria, Inflammation, Acute  |                                                                          |      1  4.0|
      Lamina Propria, Pigmentation         | 4  4  4  4     3  4  3  4                                                |     50  3.8|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                      +  +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                      +  +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Basophilic Focus                     | X  X  X        X  X     X                                                |     40     |
      Clear Cell Focus                     |    X                                                                     |      5     |
      Fatty Change                         |          3           2  2                                                |      9  2.7|
      Hematocyst                           |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                                                                          |      5     |
      Inflammation, Granulomatous          |                                                                          |     10  1.7|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |          3                                                               |     27  1.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                    +                                                   |   4        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 | 3                                                                        |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +                                                |  50        |
      Inflammation, Chronic, Diffuse       |          4                                                               |      1  4.0|
      Acinus, Atrophy                      |                                                                          |      4  1.8|
      Acinus, Hyperplasia, Focal           |    3                                                                     |      5  2.6|
      Acinus, Hypertrophy, Focal           |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
      Duct, Cyst                           |                                                                          |      1     |
      Duct, Hyperplasia                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +        +  +  +  +                                                |  28        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +                                                |  50        |
      Acanthosis                           |    3                    2                                                |      7  2.7|
      Pigmentation                         |    1                                                                     |      9  1.8|
      Ulcer                                |                                                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5|                                            |            |
                                           | 1| 1| 1| 3| 0| 1| 1| 6| 8| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +                                                |  49        |
      Edema                                |                                                                          |      1  3.0|
      Erosion, Focal                       |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +                                                |  49        |
      Cardiomyopathy                       |    1     2     2                                                         |     17  1.7|
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +                                                |  50        |
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Focal                  |                                                                          |      1  2.0|
      Degeneration                         |                3                                                         |      5  3.2|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia                          |          2                                                               |      2  2.0|
      Hypertrophy                          |                                                                          |      1  1.0|
      Necrosis                             |                      3                                                   |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +                                                |  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  +  +  M                                                |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +                                                |  50        |
      Cyst                                 | X                                                                        |      1     |
      Pars Distalis, Angiectasis           |                                                                          |      2  3.0|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
      C-Cell, Hyperplasia                  |                2                                                         |      2  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                      +  +                                                |   9        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5|                                            |            |
                                           | 1| 1| 1| 3| 0| 1| 1| 6| 8| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +     +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                      +  +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Endometriosis                        | 4                                                                        |      1  4.0|
      Hydrometra                           |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                3                                                         |      5  3.0|
      Lumen, Hemorrhage                    |                                                                          |      1  3.0|
      Wall, Necrosis                       |          4                                                               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                      +  +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +                                                |  50        |
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                         3                                                |      2  3.0|
      Pancreatic, Pigmentation             | 4  4     4     3                                                         |     33  3.9|
      Renal, Congestion                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +     +  +  +  +                                                |  46        |
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +                                                |  50        |
      Pigmentation                         | 3  4  4  4     4  4  4  1                                                |     45  3.6|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                      +  +                                                |   8        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +           +     +  +                                                |  19        |
      Hyperplasia, Cystic                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                      +  +                                                |   9        |
      Face, Abscess                        |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                      +  +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5|                                            |            |
                                           | 1| 1| 1| 3| 0| 1| 1| 6| 8| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +                                                |  50        |
      Adenomatosis                         |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      2  2.5|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                      +  +                                                |   6        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   3        |
      Lens, Mineralization                 |                4                                                         |      2  3.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Nephropathy                          | 1  3  3  3     2  1     3                                                |     42  2.4|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      5  1.4|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 4  4  4  4     4  4  4  4                                                |     49  3.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|             
                                           | 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +                 +  +                                +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +                 +  +                                +        +  A  +|             
      Parasite Metazoan                    |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                 +  +                                M        +  +  +|             
      Parasite Metazoan                    |    X                                                              3  2   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +                 +  +                                +        +  +  +|             
      Parasite Metazoan                    |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +                 +  +                                +        +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +                 +  +                                +        +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                X  X                    X           X        X        X   |             
      Clear Cell Focus                     |                                                                X         |             
      Congestion                           |                                                                          |             
      Fatty Change                         |    3  2              2  3           4                 2  4        2  4  3|             
      Fibrosis, Focal                      |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  2        3  3  3        2  3     3     3  2  2  2  2  3  2  3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +           +     +                 +        +         |             
      Fat, Necrosis, Focal                 |                4              4     3                 3        3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      | 2              2                 2     3                 2               |             
      Acinus, Hyperplasia, Focal           | 3                             3                                          |             
      Acinus, Hyperplasia                  |                   3                                                      |             
      Acinus, Vacuolization Cytoplasmic    |                                              3                           |             
      Artery, Hypertrophy                  |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Artery, Thrombosis                   |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                         3|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +  +  +           +  +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                     3                                    |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|             
                                           | 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     2        1     1  1     3  3  3  3     1  1  3  2  1  2  3  2  2  2|             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                     4                                    |             
      Vacuolization Cytoplasmic            |                               1              1                          4|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                 2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                                                                          |             
      Pars Distalis, Cyst                  |       X                                                                  |             
      Pars Distalis, Hyperplasia, Focal    |       2              2                 3                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +           +     +  +           +                    +        +  +  +|             
      Inflammation, Chronic                |    3           2                    2                    2           2  2|             
      Duct, Cyst                           |                X                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Suppurative            | 3                       2     4                          3        3  3  4|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                                         2|             
      Seminiferous Tubule, Degeneration    | 4                                   4                       3            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +                 +  +                                M        +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              | 4                                                                       4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|             
                                           | 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             | 4     4                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                          3              3|             
      Pigmentation, Hemosiderin            |                                                                2         |             
      Pigmentation                         | 1                 1           1  1     2     2     2        1        2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                              4                           |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Endothelium, Hyperplasia             | 4                                                                        |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +                 +  +                                +        +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M                 M  +                             +  +     +  M  M  M|             
      Hyperplasia, Cystic                  |                                                          3               |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +                 +  +     +        +           +     +        +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +                 +  +                                +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lateral Ventricle, Hemorrhage        |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3                 3  3                                2        3  4   |             
      Inflammation, Chronic                |    2                                                                     |             
      Inflammation, Granulomatous          |                   2                             2           2  2         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +                 +  +                                +        +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                      2                                   2              3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|             
                                           | 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +  +                                            +  +|             
      Cataract                             |                         4                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                               +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Nephropathy                          | 3     2        3  2  1  1     4  3  2  4     3  4  4  3  1  4  3  1     2|             
      Capsule, Developmental Malformation  |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Wall, Inflammation, Suppurative      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|             
                                           | 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                             A              +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                             A              +               |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                           A              +               |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                           A              +               |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                             A              +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                           A              +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Basophilic Focus                     |    X  X              X        X  X           X  X     X     X  X         |             
      Clear Cell Focus                     | X  X  X                       X  X              X  X        X            |             
      Congestion                           |                                        3                                 |             
      Fatty Change                         | 3  2     2  4                 2        2  3        3  2  2        2      |             
      Fibrosis, Focal                      |                                        3                                 |             
      Hepatodiaphragmatic Nodule           |    X                                   X              X                  |             
      Inflammation, Chronic                |                                                                          |             
      Bile Duct, Hyperplasia               | 3  3  3  1     1     3        2  2  2        1  3  2  2  2  2  2  2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic                |                                                                3         |             
      Acinus, Atrophy                      | 2                                                           1            |             
      Acinus, Hyperplasia, Focal           |                                        3                                 |             
      Acinus, Hyperplasia                  |          2        3           3                                          |             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
      Artery, Hypertrophy                  |       4                                4                                 |             
      Artery, Inflammation, Chronic        |                                                                4         |             
      Artery, Thrombosis                   |                                                                X         |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +        +     +  +  +  +     +  +  +        +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +      |             
      Serosa, Inflammation, Acute          |          4                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +      |             
      Acanthosis                           |          4           1                                                   |             
      Ulcer                                |             4                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +      |             
      Mineralization                       |                3                                                         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|             
                                           | 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Cardiomyopathy                       | 2  1  2  3  1  4  2           3  2  1  1  2  3  4  1           4  1      |             
      Fibrosis                             |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Cyst                                 |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |          3                                                               |             
      Vacuolization Cytoplasmic            |                      3           1                          1            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  M  +  +  +      |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Pars Distalis, Angiectasis, Focal    |                                                                          |             
      Pars Distalis, Cyst                  | X                                                                        |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      C-Cell, Hyperplasia                  |                                              2                    1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +           A     +                    +              +               |             
      Inflammation, Chronic                |    3                 3                                   2               |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  M  +  +  +      |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Suppurative            |    3     3  2  4     3                    2        1              3      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Dilatation                           |                4                                                         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Interstitial Cell, Hyperplasia       |          1                                                               |             
      Seminiferous Tubule, Degeneration    |          2                                   4                 4  4      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                           +              +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Mediastinal, Congestion              |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|             
                                           | 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Pigmentation            |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pigmentation                         | 1           2                 2        1     2              1     1      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Fibrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                4                                            4            |             
      Endothelium, Hyperplasia             |                                                             4            |             
      Red Pulp, Atrophy                    |                   3                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  |                      +              +  +  +              +     +         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                           +              M  +            |             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |                                                             4            |             
                                            __________________________________________________________________________|             
   Skin                                    |          +                       +        +        +     +  +  +         |             
      Cyst Epithelial Inclusion            |                                                    X                     |             
      Hyperkeratosis                       |          4                                                               |             
      Subcutaneous Tissue, Hemorrhage      |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                           +              +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Lateral Ventricle, Hemorrhage        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Congestion                           |                                        4  3        3                     |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          | 1     2                       2                 2           1     1      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                              2                           |             
      Interstitium, Inflammation, Chronic  |                      3                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    |                                           A              +               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|             
                                           | 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Cataract                             |                      4                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Congestion                           |                                        3  2        3                     |             
      Necrosis, Focal                      |                                                                          |             
      Nephropathy                          | 3  4  4  4  4  4  4  4        3  4  3  2  1  4  4  2  3  1  4  4  4      |             
      Capsule, Developmental Malformation  |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                  3                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Wall, Inflammation, Suppurative      |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5|                                            |            |
                                           | 1| 0| 5| 2| 4| 6| 7| 6| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +                                                               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +                                                               |  11        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +                                                               |  11        |
      Parasite Metazoan                    |    X                                                                     |      4  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +                                                               |  11        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +     +  +  +  +                                                |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  A  +  +                                                               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +                                                               |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Basophilic Focus                     | X  X  X        X  X                                                      |     21     |
      Clear Cell Focus                     |                   X                                                      |     10     |
      Congestion                           |                         3                                                |      2  3.0|
      Fatty Change                         | 2  2  1              4  2                                                |     26  2.6|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                      X                                                   |      4     |
      Inflammation, Chronic                |       1                                                                  |      1  1.0|
      Bile Duct, Hyperplasia               | 3  1           3  3  2  3                                                |     40  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   7        |
      Fat, Necrosis, Focal                 |                                                                          |      5  3.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +                                                |  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                2                                                         |      8  2.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      3  3.0|
      Acinus, Hyperplasia                  |                      2                                                   |      5  2.6|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  3.0|
      Artery, Hypertrophy                  |                                                                          |      2  4.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
      Artery, Thrombosis                   |                                                                          |      1     |
      Serosa, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +        +                                                      |  40        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +                                                |  49        |
      Serosa, Inflammation, Acute          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +                                                |  49        |
      Acanthosis                           |    3                                                                     |      4  2.8|
      Ulcer                                |                      4                                                   |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5|                                            |            |
                                           | 1| 0| 5| 2| 4| 6| 7| 6| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +                                                |  49        |
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis                             |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Cardiomyopathy                       | 2     1        1        4                                                |     40  2.1|
      Fibrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +                                                |  50        |
      Cyst                                 |                   X                                                      |      1     |
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      2  3.5|
      Vacuolization Cytoplasmic            |          1                                                               |      7  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +                                                |  49        |
      Hyperplasia, Focal                   |                   2                                                      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +                                                |  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +                                                |  50        |
      Pars Distalis, Angiectasis, Focal    |       3                                                                  |      1  3.0|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
      C-Cell, Hyperplasia                  |                   2                                                      |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +                                                               |  17        |
      Inflammation, Chronic                | 2                                                                        |     10  2.3|
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +                                                |  49        |
      Hyperplasia, Focal                   |    2                                                                     |      1  2.0|
      Inflammation, Suppurative            | 1     2  2        3                                                      |     19  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5|                                            |            |
                                           | 1| 0| 5| 2| 4| 6| 7| 6| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +                                                |  50        |
      Dilatation                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Interstitial Cell, Hyperplasia       |                                                                          |      2  1.5|
      Seminiferous Tubule, Degeneration    |                                                                          |      7  3.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +                                                               |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +                                                |  50        |
      Mediastinal, Congestion              | 2                       3                                                |      5  3.4|
      Mediastinal, Pigmentation            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +     +  +  +  +                                                |  49        |
      Hyperplasia, Plasma Cell             |       3                                                                  |      3  3.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +                                                |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Pigmentation                         |       2        1  1  1                                                   |     20  1.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Fibrosis                             |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                                                                          |      2  4.0|
      Endothelium, Hyperplasia             |                                                                          |      2  4.0|
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +              +                                                |  17        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +     +                                                         |   9        |
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  M  +                                                               |  20        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                                                               |  13        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Lateral Ventricle, Hemorrhage        |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5|                                            |            |
                                           | 1| 0| 5| 2| 4| 6| 7| 6| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +                                                |  50        |
      Congestion                           | 3  3                    3                                                |     12  3.1|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                   1                                                      |     11  1.6|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +                                                               |  12        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
      Cataract                             |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Congestion                           |                         3                                                |      4  2.8|
      Necrosis, Focal                      |          4                                                               |      1  4.0|
      Nephropathy                          | 1     2  3     2  4  4  3                                                |     47  3.0|
      Capsule, Developmental Malformation  |                         X                                                |      1     |
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +                                                |  50        |
      Wall, Inflammation, Suppurative      |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|             
                                           | 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +           +                 +  +  +        +     +               |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +        +  +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +        +  +                 +  +  +        +     +               |             
      Parasite Metazoan                    | X                                   X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +           +                 +  +  +        +     +               |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Lamina Propria, Pigmentation         | 2  4  3        4  1  4  4     3  4  4  4  4  4  4  3     4  4  4  4  4   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +           +  +  +  +        +     +        +      |             
      Basophilic Focus                     |       X        X                                                         |             
      Congestion                           |                                                                          |             
      Fatty Change                         | 2     3              3              3  4  4        2     3               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X           X                    X                             X      |             
      Bile Duct, Hyperplasia               |    2  3        3     3              2              2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +        +   |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Fat, Necrosis, Focal                 |                                                             4        4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +           +  +              +  +  +        +     +     +         |             
      Acinus, Atrophy                      |                                        2                                 |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Artery, Media, Hyperplasia           |                                                                          |             
      Duct, Ectasia, Multifocal            |                      3                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +           +                 +  +  +        +     +               |             
      Acanthosis                           |       2                                                                  |             
      Pigmentation, Focal                  |                                                                          |             
      Pigmentation                         |                                                                          |             
      Ulcer                                |    4                                   4           4                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +           +                 +  +  +        +     +               |             
      Muscularis, Inflammation, Chronic    |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +           +                 +  +  +        +     +               |             
      Cardiomyopathy                       |       2                             1              1                     |             
      Inflammation, Chronic                | 2                 2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|             
                                           | 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Artery, Myocardium, Inflammation,    |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Degeneration                         |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                   1      |             
      Hypertrophy                          |                                                             1            |             
      Vacuolization Cytoplasmic, Diffuse   |                                     2                                    |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Vacuolization Cytoplasmic            |    2           1  3     1              1                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +        +  +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     M           M                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Pars Distalis, Angiectasis, Focal    |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                2        2                          3        3  3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +           +                 +  +  +        +     +               |             
      C-Cell, Hyperplasia                  |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +           +                 +  +  +  +  +  +     +               |             
      Inflammation, Chronic                |                                           2              2               |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +           +                 +  +  +        +     +               |             
      Inflammation, Chronic                |                                     1                                    |             
      Inflammation, Suppurative            |                   2                    4                                 |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +           +     +           +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Interstitial Cell, Hyperplasia       | 2                                      1                 2               |             
      Seminiferous Tubule, Degeneration    |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|             
                                           | 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Pigmentation            |    1                                                                     |             
      Pancreatic, Pigmentation             |                      4        4  4  4     3  4  4           4     4  4   |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +           +     +           +  +  +        M     M               |             
      Hyperplasia, Plasma Cell             |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +     +  +  +  +  +  +  M  +     +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                      4           1  2  4     2           4  2  4  3  2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +           +  +  +        +  +  +  +  +  +  +     +               |             
      Congestion                           |                                     3                                    |             
      Ectopic Tissue                       |                   X                                                      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Re Cell                 |                                              3                           |             
      Pigmentation, Hemosiderin            |                                        4                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +           +                 +  +  M        +     +               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +        +  +           +     M  M  M        M     +               |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Focal, Granulomatous   |                               4                                          |             
      Duct, Cyst                           |                               X                                          |             
      Duct, Hemorrhage, Chronic            |                3                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +           +                 +  +  +        +     +        +      |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Head, Inflammation, Acute            |                                                                   3      |             
      Subcutaneous Tissue, Hemorrhage      |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +           +                 +  +  +        +     +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +           +                 +  +  +        +     +               |             
      Pons, Hemorrhage                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +           +                 +  +  +     +  +     +               |             
      Congestion                           | 3                                   3  3        3  3     3               |             
      Hemorrhage                           |                   3                                                      |             
      Inflammation, Granulomatous          |                                                                          |             
      Alveolus, Inflammation, Acute        |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +           +                 +  +  +        +     +               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                   2                                3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|             
                                           | 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Sinus, Inflammation, Chronic         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +           +                 +  +  +        +     +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Nephropathy                          |    4  2        4  1  2  3     3  3  4  4  1  2  3  2     2  3  4  4  2   |             
      Artery, Pelvis, Inflammation, Chronic|                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                               1                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |    3           3                 3  3  3        3           3  3  3  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Concretion                           |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|             
                             DAY ON TEST   | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|             
                                           | 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .0125 G/                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +                             M        +        +     +     M|             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +                             +        +        +     +     A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +                             +        +        +     +     A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +                             +        +        +     +     A|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +                             +        +        +     +     A|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
      Lamina Propria, Pigmentation         | 4  3  3  3  3  4  4  3  3     4  4  4  4  4  2  3  3        2     3     1|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +                             +        +        +     +     A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +                             +        +        +     +     A|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +        +  +     +  +     +  +        +        +     +     A|             
      Basophilic Focus                     |                                  X                                       |             
      Congestion                           |                                                                          |             
      Fatty Change                         |    1  3     4        3  1                          2                     |             
      Hematopoietic Cell Proliferation     |                                                             1            |             
      Hepatodiaphragmatic Nodule           |    X                                                                     |             
      Bile Duct, Hyperplasia               |    1     2           1  1     2        2  2        2        1     3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +        +     +     +                                          |             
      Artery, Inflammation, Chronic        |          4                                                               |             
      Fat, Necrosis, Focal                 |                               4                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +                    +        +        +        +     +     M|             
      Acinus, Atrophy                      |             3                                                            |             
      Artery, Inflammation, Chronic        |          4                                                               |             
      Artery, Media, Hyperplasia           |                                  4                                       |             
      Duct, Ectasia, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +                             +        +        +     +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +                             +        +        +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +                             +        +        +     +     +|             
      Acanthosis                           |                                                                          |             
      Pigmentation, Focal                  |                                                    3                     |             
      Pigmentation                         |                                                                   2      |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +                             +        +        +     +     +|             
      Muscularis, Inflammation, Chronic    |          3                                                               |             
      Serosa, Inflammation, Chronic        |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +                             +        +        +     +     +|             
      Cardiomyopathy                       | 3  2        2                                      2              2      |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|             
                             DAY ON TEST   | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|             
                                           | 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .0125 G/                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Artery, Myocardium, Inflammation,    |                                                                          |             
           Chronic                         |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
      Degeneration                         |                4                                                         |             
      Hyperplasia, Focal                   |                         4     2                                   2      |             
      Hypertrophy, Focal                   |                                                                          |             
      Hypertrophy                          |    1                    1                                   1            |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Vacuolization Cytoplasmic            |                      1           1           1  1           1            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
      Hyperplasia, Focal                   |                   2                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +                    +        +        +        +     +     M|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  M  M                             M        +        +     +     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
      Pars Distalis, Angiectasis, Focal    |                                              3                           |             
      Pars Distalis, Hyperplasia, Focal    |       1  2              2                                         3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +                 +           +        +        +     +     A|             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +  +           +                 +        +        +     +     M|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +           +                 +        +        +     +     +|             
      Inflammation, Chronic                |          2                                         2                     |             
      Inflammation, Suppurative            |                         3                                                |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +                             +        +        +     +     +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                    3              2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  +  +  +     +                 +  +        +        +     +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Degeneration    |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +                             +        +        +     +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mediastinal, Congestion              |          3                          4                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|             
                             DAY ON TEST   | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|             
                                           | 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .0125 G/                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Pigmentation            |       3                                   3                              |             
      Pancreatic, Pigmentation             |    3                    4     4           4  4              4            |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       M  +  M                             +        +        +     +     +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |    3  3  3        2  3  2                    2     4        3            |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +                 +        +  +     +  +        +     +     +|             
      Congestion                           |                                                 4                        |             
      Ectopic Tissue                       |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                             4            |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +                             +        +        +     +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  M                             M        +                    M|             
      Hyperplasia, Cystic                  |                                                    3                     |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Duct, Cyst                           |                                                                          |             
      Duct, Hemorrhage, Chronic            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +  +                 +     +        +        +     +     +|             
      Cyst Epithelial Inclusion            |                   X                                                      |             
      Head, Inflammation, Acute            |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +                             +        +              +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +                             +        +        +     +     +|             
      Pons, Hemorrhage                     |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +                    +  +  +  +  +  +  +        +     +     +|             
      Congestion                           | 4  4  3     3                    3  3        4  4                 3     4|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Granulomatous          | 2                                                                        |             
      Alveolus, Inflammation, Acute        |                                                                          |             
      Perivascular, Inflammation, Chronic  |             3                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +           +                 +        +        +     +     +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|             
                             DAY ON TEST   | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|             
                                           | 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .0125 G/                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Sinus, Inflammation, Chronic         |             2                                                     2      |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +                             +        +        +     +     A|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +           +        +                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     A|             
      Nephropathy                          | 4  3  3  2     2  2  3  2     4  4  1  2  2  4  4  3        2     4      |             
      Artery, Pelvis, Inflammation, Chronic|          3                                                               |             
      Renal Tubule, Hyperplasia, Focal     |                               2                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 3  3     3     2  3  3  4     3  2     3           3        2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  A  +        +     +     +|             
      Concretion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0|                                            |            |
                                           | 3| 8| 3| 8| 0| 3| 3| 3| 4| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +           +  +                                             |  18        |
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Suppurative                     |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +  +           +  +                                             |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  +           +  A                                             |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +           +  A                                             |  19        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  +           +  +                                             |  19        |
      Parasite Metazoan                    |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lamina Propria, Pigmentation         | 4  3  3  3  3  4  4  4  4  3                                             |     50  3.4|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  +           +  A                                             |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +           +  A                                             |  18        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +     +  +           +  +                                             |  31        |
      Basophilic Focus                     |    X     X                                                               |      5     |
      Congestion                           |    3                    4                                                |      2  3.5|
      Fatty Change                         |          2  3           2  3                                             |     18  2.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      5     |
      Bile Duct, Hyperplasia               |    2     2  2           2                                                |     20  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                    +                                             |   8        |
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
      Fat, Necrosis, Focal                 |       4                    3                                             |      5  3.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  +           +  +                                             |  22        |
      Acinus, Atrophy                      |          2                                                               |      3  2.3|
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
      Artery, Media, Hyperplasia           |                                                                          |      1  4.0|
      Duct, Ectasia, Multifocal            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +           +  +                                             |  20        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +  +           +  +                                             |  23        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +           +  +                                             |  23        |
      Acanthosis                           |                                                                          |      1  2.0|
      Pigmentation, Focal                  |                                                                          |      1  3.0|
      Pigmentation                         |       3                                                                  |      2  2.5|
      Ulcer                                |                                                                          |      3  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +           +  +                                             |  23        |
      Muscularis, Inflammation, Chronic    |                                                                          |      1  3.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0|                                            |            |
                                           | 3| 8| 3| 8| 0| 3| 3| 3| 4| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +           +  +                                             |  22        |
      Cardiomyopathy                       |             2           3                                                |     10  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Artery, Myocardium, Inflammation,    |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Degeneration                         |                                                                          |      1  4.0|
      Hyperplasia, Focal                   |                   2     2                                                |      5  2.4|
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
      Hypertrophy                          |                                                                          |      4  1.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |          2                                                               |      1  2.0|
      Vacuolization Cytoplasmic            |    2        1                                                            |     12  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Focal                   |                2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +           +  +                                             |  22        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +  +           +  M                                             |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Angiectasis, Focal    |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |                         3                                                |     10  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +           +  +                                             |  20        |
      C-Cell, Hyperplasia                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +  +           +  +                                             |  20        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +  +           +  +                                             |  24        |
      Inflammation, Chronic                |                                                                          |      4  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |          M  +           +  +                                             |  19        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                         2                                                |      5  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0|                                            |            |
                                           | 3| 8| 3| 8| 0| 3| 3| 3| 4| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +  +  +        +  +                                             |  25        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Interstitial Cell, Hyperplasia       |                   2                                                      |      4  1.8|
      Seminiferous Tubule, Degeneration    |                4                                                         |      3  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +           +  +                                             |  20        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lumbar, Hyperplasia, Lymphoid        |       3                                                                  |      1  3.0|
      Mediastinal, Congestion              |                                                                          |      2  3.5|
      Mediastinal, Pigmentation            |                                                                          |      3  2.3|
      Pancreatic, Pigmentation             | 4  2  3        3     4  4                                                |     22  3.7|
      Renal, Pigmentation                  |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          M  M           M  +                                             |  14        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia, Lymphoid                |             3                                                            |      1  3.0|
      Pigmentation                         |    4     2           3                                                   |     22  2.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +           +  +                                             |  29        |
      Congestion                           |                                                                          |      2  3.5|
      Ectopic Tissue                       |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  M           M  +                                             |  17        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +  M           M  M                                             |  10        |
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  4.0|
      Duct, Cyst                           |                                                                          |      1     |
      Duct, Hemorrhage, Chronic            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +  +        +  +  +                                             |  26        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Head, Inflammation, Acute            |                                                                          |      1  3.0|
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +           +  +                                             |  19        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0|                                            |            |
                                           | 3| 8| 3| 8| 0| 3| 3| 3| 4| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +           +  +                                             |  20        |
      Pons, Hemorrhage                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +  +  +        +  +                                             |  30        |
      Congestion                           |    3     4  3  3        4  4                                             |     22  3.4|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Alveolus, Inflammation, Acute        |             3                                                            |      1  3.0|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +           +  +                                             |  21        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |             2                                                            |      4  2.3|
      Sinus, Inflammation, Chronic         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  +           +  +                                             |  19        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Nephropathy                          | 3  4  2  3  1  4  2  4  3                                                |     46  2.8|
      Artery, Pelvis, Inflammation, Chronic|                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      2  1.5|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 3  3           3  2  2                                                   |     27  2.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Concretion                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|             
                                           | 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +                             +        +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +                             +        +  +           +  +   |             
      Colon, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +                             +        +  +           +  +   |             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +                             M        +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Lamina Propria, Pigmentation         | 4  4  4  3  4     4  4  4        3  4  4  4  3  3  4  3     3  4  4  3   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +                             +        +  +     +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +                             +        +  +           +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Basophilic Focus                     |    X  X              X  X        X     X     X  X           X            |             
      Clear Cell Focus                     |                      X              X        X              X            |             
      Congestion                           |                                                                          |             
      Fatty Change                         |          2                                            2        3  2  2   |             
      Hepatodiaphragmatic Nodule           |                                                 X                        |             
      Inflammation, Acute, Focal           |                                                                          |             
      Necrosis                             |                                           2                              |             
      Bile Duct, Hyperplasia               | 3  3  1           2  2           3  3  1  3  3  2  1  1     2  2  2      |             
      Centrilobular, Degeneration          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +        +           +                           |             
      Artery, Inflammation, Acute          |                                  4                                       |             
      Fat, Necrosis, Focal                 |                         3        2           3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic                | 2                                                                        |             
      Acinus, Atrophy                      |                                        2        2                        |             
      Acinus, Hyperplasia, Focal           |                                        2                    2            |             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Hypertrophy                  |                                                 4                        |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +     +     +           +  +  +  +  +  +  +     +     +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Acanthosis                           |       2                             2                                    |             
      Pigmentation                         |                                     3                                    |             
      Ulcer                                |          4                                            2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Mineralization                       |             3                                                            |             
      Necrosis                             |                                           4                              |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                  +                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|             
                                           | 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Cardiomyopathy                       | 2  2  1  3           2              3  3  2  2  2  1           2  2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Hyperplasia, Focal                   | 2  2                                2                                    |             
      Hypertrophy, Focal                   |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                  1                                3      |             
      Vacuolization Cytoplasmic            |    1     4                                            1        3         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Hyperplasia, Focal                   |             3                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Hyperplasia                          |                   3                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  M     +  M  +  +   |             
      Hyperplasia                          |             3                                                            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +        +  +  +  +  +  +  M  +     +  +  +  +   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    2                 2                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +                          +  +     +  +  +           +  +   |             
      Inflammation, Chronic                | 3                                                                        |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                                              3  3  2  4           2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Seminiferous Tubule, Degeneration    |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +                             +        +  +           +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Mediastinal, Congestion              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|             
                                           | 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Cyst                    |                      X                                                   |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Cyst                     |                                                                          |             
      Pancreatic, Pigmentation             |          4  4     4  4  4                 4  4                           |             
      Renal, Congestion                    |             4                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +     +        +  +  +  +  +  +  +  M     +  +  M  +   |             
      Hyperplasia, Plasma Cell             | 4                                3                             4         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Congestion                           |                                                                          |             
      Necrosis, Focal                      |                                                             3            |             
      Pigmentation                         | 4  4  3  4  4     4  4  4        4  2  4  4  4  4  4  3        2     4   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Cyst                                 |                                           X                              |             
      Fibrosis                             |                   2                                                      |             
      Hyperplasia, Nodular                 |                                                                          |             
      Pigmentation, Hemosiderin            |                                                       4                  |             
      Endothelium, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +        +                    +        M  +           +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  M                             +        +  M           +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +           +                 +  +     +  +           +  +   |             
      Hyperkeratosis                       |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +                             +           +           +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Adenomatosis                         |                                                                          |             
      Congestion                           |       4                                3                          3      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Alveolar Epithelium, Pigmentation    |                                                       2                  |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +                             +        M  +           +  +   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|             
                                           | 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Mucosa, Pigmentation                 |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +  +                          M                     |             
      Cataract                             |                         3                                                |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Cyst                                 | X                                                                        |             
      Nephropathy                          | 4  4  2  4  4     4  4  4        3  4  4  2  4  4  3  4     4  3  3  3   |             
      Renal Tubule, Hyperplasia, Focal     |             2                                   1     1                  |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 3  3     3  3     3  3  3        3  4  3     4  3  3  4     3  3  3      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Concretion                           |             3                                                            |             
      Mucosa, Hyperplasia, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|             
                             DAY ON TEST   | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|             
                                           | 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .025G/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +        +        +           +  +     +  +  +  +     +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +        +        +           +  +     +  +  +  +               |             
      Colon, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +        +        +           +  +     +  +  +  +     +         |             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +        +        +           +  +     +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Lamina Propria, Pigmentation         | 4  4  4  4     3  4  4  3  4  3  4  4  4  3  4  3  4  2  4  4  3  3      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +        +        +              A        +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +        +        +              +        +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Basophilic Focus                     | X              X  X  X              X        X              X            |             
      Clear Cell Focus                     |                X  X                                                      |             
      Congestion                           |                         3           3  4                    3            |             
      Fatty Change                         |                   2        2           2  2     1  2  3           1      |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Acute, Focal           |                                                                   2      |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               | 3  3  3  2     2     2  1  2  2  1     2     1  1  2  2  2  2  1  3      |             
      Centrilobular, Degeneration          |                                                       3                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Artery, Inflammation, Acute          |                                                                          |             
      Fat, Necrosis, Focal                 |                   4                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                                              3                           |             
      Acinus, Hyperplasia, Focal           | 3                                                              4         |             
      Acinus, Hyperplasia                  |                                  3                          3            |             
      Artery, Hypertrophy                  |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +     +  +     +  +           +  +     +  +  +  +     +         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Acanthosis                           |                               2                                          |             
      Pigmentation                         |          1                             1                 1  2            |             
      Ulcer                                |          3                                                  4  4         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|             
                             DAY ON TEST   | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|             
                                           | 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .025G/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Cardiomyopathy                       | 1  2     2     2  2  1        2  1     2  3        3     2  3     2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia, Focal                   |                                     2     3                              |             
      Hypertrophy, Focal                   |                                                                          |             
      Hypertrophy                          |                                                                1         |             
      Metaplasia, Osseous                  |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Vacuolization Cytoplasmic            |    1  1        1              2  1  1                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia, Focal                   |    2                 1        2                             3            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     M  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    3                       2                                2  2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +           +     +           +  +     +  +  +  +        +      |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Cyst                           |                      X                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Subacute               |                                                          2               |             
      Inflammation, Suppurative            | 3        2           2                    3                       2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Seminiferous Tubule, Degeneration    |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +        +        +           +  M     +  +  +  +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Mediastinal, Congestion              |                3                                3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|             
                             DAY ON TEST   | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|             
                                           | 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .025G/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Cyst                    |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                    3                     |             
      Mediastinal, Pigmentation            |                2                                                         |             
      Pancreatic, Cyst                     |                X                                                         |             
      Pancreatic, Pigmentation             | 4  4     4           4     4     4                 4           4  4      |             
      Renal, Congestion                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia, Plasma Cell             |                      4                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Congestion                           |          4                                                               |             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation                         | 4  3     3     1     4  2  2  4  2  1     4  4  4  4     4  4     3      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Nodular                 |                               4                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Endothelium, Hyperplasia             |                                                                   4      |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +        +     +  +           +  +     +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          +        +        M           M  M     M  M  M  +        +      |             
      Hyperplasia                          |                                                                   3      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +        +        +           +  +  +  +  +  +  +  +            |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +        +        +           +  +     +  +  +  +               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Adenomatosis                         |                         3                                                |             
      Congestion                           |                         3  3        3  4  3     4  3  3     3  4         |             
      Hemorrhage                           |          3                                                               |             
      Inflammation, Granulomatous          |                      2                                                   |             
      Alveolar Epithelium, Pigmentation    |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                       2                  |             
                                            __________________________________________________________________________|             
   Nose                                    |          +        +        +           +  +     +  +  +  +               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|             
                             DAY ON TEST   | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|             
                                           | 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .025G/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Mucosa, Pigmentation                 |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                                  |             
      Cataract                             |                                                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |       3                                                                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 4  4  4  3     4  2  4  2  3  4  4  4  2  2  4  2  3  2  2  4  4  4      |             
      Renal Tubule, Hyperplasia, Focal     |                               2                                2         |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 3  3  4  3     3  2  3     4  4  3  3  3     3  3           3  3  3      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Concretion                           |                                                                          |             
      Mucosa, Hyperplasia, Focal           |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 5| 5| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5|                                            |            |
                                           | 4| 4| 5| 5| 6| 2| 6| 2| 2| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +     +  +  +  +                                                |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +     +  +  +  +                                                |  22        |
      Colon, Parasite Metazoan             |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +  +  +  +                                                |  22        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +     +  +  +  +                                                |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +                                                |  50        |
      Lamina Propria, Pigmentation         | 4  4  4  4     4  4  4  3                                                |     50  3.7|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +     +  +  +  +                                                |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +     +  +  +  +                                                |  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Basophilic Focus                     |    X                                                                     |     17     |
      Clear Cell Focus                     | X                                                                        |      7     |
      Congestion                           |                                                                          |      4  3.3|
      Fatty Change                         |                2  2  3  2                                                |     17  2.1|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 2  2  2        1     1  2                                                |     41  2.0|
      Centrilobular, Degeneration          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Artery, Inflammation, Acute          |                                                                          |      1  4.0|
      Fat, Necrosis, Focal                 |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +                                                |  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      3  2.3|
      Acinus, Hyperplasia, Focal           |                                                                          |      4  2.8|
      Acinus, Hyperplasia                  |                                                                          |      2  3.0|
      Artery, Hypertrophy                  |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic        |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +     +  +  +  +                                                |  37        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +                                                |  50        |
      Acanthosis                           |                2                                                         |      4  2.0|
      Pigmentation                         |                2                                                         |      6  1.7|
      Ulcer                                |                         2                                                |      6  3.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 5| 5| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5|                                            |            |
                                           | 4| 4| 5| 5| 6| 2| 6| 2| 2| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Cardiomyopathy                       | 2     2              2                                                   |     30  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +                                                |  50        |
      Hyperplasia, Focal                   |                                                                          |      5  2.2|
      Hypertrophy, Focal                   |                   1                                                      |      1  1.0|
      Hypertrophy                          |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |    2                                                                     |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            | 1     2                                                                  |     12  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +                                                |  50        |
      Hyperplasia, Focal                   |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +                                                |  50        |
      Hyperplasia                          |                      3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  +  +  +                                                |  44        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +                                                |  49        |
      Pars Distalis, Cyst                  |          X                                                               |      1     |
      Pars Distalis, Hyperplasia, Focal    |    3                 2                                                   |      8  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
      C-Cell, Hyperplasia                  | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +     +  +  +  +                                                |  26        |
      Inflammation, Chronic                |                2  1     2                                                |      4  2.0|
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 5| 5| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5|                                            |            |
                                           | 4| 4| 5| 5| 6| 2| 6| 2| 2| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                      2                                                   |     11  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Seminiferous Tubule, Degeneration    |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +     +  +  +  +                                                |  21        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +                                                |  50        |
      Mediastinal, Congestion              |                4                                                         |      3  3.3|
      Mediastinal, Cyst                    |                                                                          |      1     |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
      Pancreatic, Cyst                     |                                                                          |      1     |
      Pancreatic, Pigmentation             | 4  4  4        4        4                                                |     21  4.0|
      Renal, Congestion                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +                                                |  47        |
      Hyperplasia, Plasma Cell             |                                                                          |      4  3.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +                                                |  50        |
      Congestion                           |                                                                          |      1  4.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Pigmentation                         | 4  4  3  4     4     2  4                                                |     42  3.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Cyst                                 |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia, Nodular                 |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  4.0|
      Endothelium, Hyperplasia             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +     +  +  +  +                                                |  24        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                M  +  M  +                                                |  12        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |          +     +  +  +  +                                                |  28        |
      Hyperkeratosis                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +  +  +                                                |  20        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05043-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:17:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 5| 5| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5|                                            |            |
                                           | 4| 4| 5| 5| 6| 2| 6| 2| 2| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +                                                |  50        |
      Adenomatosis                         |                                                                          |      1  3.0|
      Congestion                           |    3           4     2                                                   |     16  3.3|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Alveolar Epithelium, Pigmentation    |                                                                          |      1  2.0|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +     +  +  +  +                                                |  21        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +                                                |  50        |
      Mucosa, Pigmentation                 |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cataract                             |                                                                          |      1  3.0|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Cyst                                 |                                                                          |      1     |
      Nephropathy                          | 4  4  3  2     3  2  2  2                                                |     50  3.3|
      Renal Tubule, Hyperplasia, Focal     | 2                                                                        |      6  1.7|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 3  3  4  4     3  2  3  3                                                |     42  3.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +                                                |  50        |
      Concretion                           |                                                                          |      1  3.0|
      Mucosa, Hyperplasia, Focal           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.