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TDMS Study 05044-02 Pathology Tables

NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  106-87-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 2| 6| 2| 2| 9| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 2| 3| 9| 3| 1|             
                                           | 9| 1| 9| 9| 9| 9| 4| 9| 9| 3| 0| 0| 0| 0| 9| 4| 0| 0| 0| 0| 1| 1| 7| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Chronic Active         |                3                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Necrosis, Coagulative                |                   4                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2                                       |             
      Cyst                                 |             X                                                            |             
      Degeneration, Cystic                 |          2                                                               |             
      Erythrophagocytosis                  |                                                             3            |             
      Hematopoietic Cell Proliferation     |                   1                                                      |             
      Hepatodiaphragmatic Nodule           |                                                                      X   |             
      Inclusion Body Intracytoplasmic      |                      1                                                   |             
      Necrosis, Coagulative, Multifocal    |                2                                                         |             
      Serosa, Fibrosis, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +        +              +                 +            |             
      Inflammation, Chronic                |                2                                                         |             
      Inflammation, Subacute               |                                                             2            |             
      Necrosis                             |                            3                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                            3                                             |             
      Acinus, Atrophy                      | 1              3              4                             3            |             
      Duct, Ectasia                        |                               4                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                              1                           |             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |                                              1                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |             1                 1  1                                   2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 2| 6| 2| 2| 9| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 2| 3| 9| 3| 1|             
                                           | 9| 1| 9| 9| 9| 9| 4| 9| 9| 3| 0| 0| 0| 0| 9| 4| 0| 0| 0| 0| 1| 1| 7| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |             +                                                            |             
      Aorta, Inflammation, Chronic Active  |             2                                                            |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Valve, Bacterium                     |                                                                          |             
      Valve, Inflammation, Subacute        |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 2  2  3  2  2  2  1  2  2  2  2  3  2  2  3  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                   2                                2  2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |          1                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                      3   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Nodular  |                3                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Hyperplasia, Nodular       |       3     1  1              2     3        2                    2  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       4           4     4                 4                              |             
      Cyst                                 |    X  X  X  X     X     X                 X     X        X               |             
      Hyperplasia, Tubular                 |                                           3                              |             
      Bilateral, Atrophy                   |                                                                          |             
      Bilateral, Cyst                      |                      X                                                   |             
      Bilateral, Hyperplasia, Tubular      |                                        3                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 4  3  4  3  4  2  1  4  4  3  4  1  4     2     4  4  4  2  2  4  2  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis, Multifocal   |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 2| 6| 2| 2| 9| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 2| 3| 9| 3| 1|             
                                           | 9| 1| 9| 9| 9| 9| 4| 9| 9| 3| 0| 0| 0| 0| 9| 4| 0| 0| 0| 0| 1| 1| 7| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sternal, Myelofibrosis, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +     +                 +                                    |             
      Amyloid Deposition                   |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                          3               |             
      Hematopoietic Cell Proliferation     |                            1                                            2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inguinal, Hyperplasia, Cystic        |                               4        3                                 |             
      Inguinal, Inflammation, Chronic      |                            1                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      1                                      2        1   |             
      Edema                                |                               4                                          |             
      Hyperkeratosis                       |                                                                      1   |             
      Inflammation, Necrotizing            |                                                                      1   |             
      Parasite Metazoan                    |                                                             X            |             
      Back, Acanthosis                     |                                                             1            |             
      Back, Parasite Metazoan              |                                                             X            |             
      Scapula, Acanthosis                  |                               1     1                       2            |             
      Scapula, Hyperkeratosis              |                                     1                                    |             
      Scapula, Inflammation, Chronic       |                1              1                                          |             
      Scapula, Inflammation, Necrotizing   |                                                             3            |             
      Scapula, Parasite Metazoan           |                                                             X            |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
      Subcutaneous Tissue, Necrosis,       |                                                                          |             
          Multifocal                       |                            3                                             |             
      Subcutaneous Tissue, Scapula,        |                                                                          |             
          Necrosis, Multifocal             |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
      Abdominal, Inflammation, Acute       |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multifocal               |                                                                          |             
      Mineralization, Multifocal           |    1  1  1     1  1  1        1  1  1     1     1     1                 1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 2| 6| 2| 2| 9| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 2| 3| 9| 3| 1|             
                                           | 9| 1| 9| 9| 9| 9| 4| 9| 9| 3| 0| 0| 0| 0| 9| 4| 0| 0| 0| 0| 1| 1| 7| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hypothalamus, Compression            |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Diffuse                  |                                                                          |             
      Hemorrhage, Multifocal               |                                                             1            |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                         2|             
      Interstitium, Inflammation, Chronic  |                                                                         2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                            1                                             |             
      Thrombosis                           |                X                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 5| 0| 5| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 6| 3| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 3| 6| 9| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 9| 9| 3| 6| 3| 0|             
                                           | 1| 1| 1| 1| 1| 1| 4| 4| 3| 1| 2| 5| 5| 2| 2| 7| 2| 2| 2| 8| 2| 2| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                          4               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                          2               |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |                                                    2                     |             
      Erythrophagocytosis                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inclusion Body Intracytoplasmic      |                                  1                                       |             
      Necrosis, Coagulative, Multifocal    |                                                          2               |             
      Serosa, Fibrosis, Focal              |                                                    1                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             3  1              4                                4     3   |             
      Erosion                              |                                                                3         |             
      Hyperkeratosis                       |                1                                                         |             
      Inflammation, Chronic Active         |                                                                      2   |             
      Ulcer                                |                               2                 1                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 5| 0| 5| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 6| 3| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 3| 6| 9| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 9| 9| 3| 6| 3| 0|             
                                           | 1| 1| 1| 1| 1| 1| 4| 4| 3| 1| 2| 5| 5| 2| 2| 7| 2| 2| 2| 8| 2| 2| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Valve, Bacterium                     |                                                             X            |             
      Valve, Inflammation, Subacute        |                                                             4            |             
      Valve, Thrombosis                    |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2     2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                                                                1        2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |          1                                      1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Nodular  | 3                          3                             3               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |          X                                                               |             
      Follicle, Hyperplasia, Nodular       | 2        1     2           2                       1  1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                         +|             
      Duct, Dilatation                     |                                                                         2|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          4                 4           4                 4        4      |             
      Cyst                                 | X  X     X        X     X  X                       X     X  X  X  X      |             
      Hyperplasia, Tubular                 |                                                                          |             
      Bilateral, Atrophy                   |                         4        4                             4         |             
      Bilateral, Cyst                      |                X                       X                                X|             
      Bilateral, Hyperplasia, Tubular      |                         2        2                             2         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   3                                                      |             
      Endometrium, Hyperplasia, Cystic     | 4     3  3  4  4        4  4  4  1  3  2  3  2  4  3  4  2  2  2     4  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                             +            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis, Multifocal   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 5| 0| 5| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 6| 3| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 3| 6| 9| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 9| 9| 3| 6| 3| 0|             
                                           | 1| 1| 1| 1| 1| 1| 4| 4| 3| 1| 2| 5| 5| 2| 2| 7| 2| 2| 2| 8| 2| 2| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sternal, Myelofibrosis, Multifocal   |                                                 1                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +                       +                    +               |             
      Amyloid Deposition                   |                                                          3               |             
      Sinus, Ectasia                       |                                                          3               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                         3|             
      Hematopoietic Cell Proliferation     |                                                          2               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Cystic        | 1                                2                                       |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 1                                                                        |             
      Edema                                |                                                                         3|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
      Back, Acanthosis                     |                                                                          |             
      Back, Parasite Metazoan              |                                                                          |             
      Scapula, Acanthosis                  |    1                                                                     |             
      Scapula, Hyperkeratosis              |                                                                          |             
      Scapula, Inflammation, Chronic       |                                                                          |             
      Scapula, Inflammation, Necrotizing   |    1                                                                     |             
      Scapula, Parasite Metazoan           |          X                                                               |             
      Subcutaneous Tissue, Fibrosis        |                                           2                              |             
      Subcutaneous Tissue, Necrosis,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Subcutaneous Tissue, Scapula,        |                                                                          |             
          Necrosis, Multifocal             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Abdominal, Inflammation, Acute       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multifocal               |                      1                                                   |             
      Mineralization, Multifocal           |       1  1  1  1              1     1     1  1  1  1  1  1     1  1  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 5| 0| 5| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 6| 3| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 3| 6| 9| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 9| 9| 3| 6| 3| 0|             
                                           | 1| 1| 1| 1| 1| 1| 4| 4| 3| 1| 2| 5| 5| 2| 2| 7| 2| 2| 2| 8| 2| 2| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hypothalamus, Compression            |                                  4                             3         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Diffuse                  |                                              3                    2      |             
      Hemorrhage, Multifocal               |                      2                                      3            |             
      Alveolar Epithelium, Hyperplasia     |                                                 2                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 8| 9| 9| 8| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  48        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      2  2.0|
      Erythrophagocytosis                  |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Inclusion Body Intracytoplasmic      |                                                                          |      2  1.0|
      Necrosis, Coagulative, Multifocal    |                                                                          |      2  2.0|
      Serosa, Fibrosis, Focal              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                                                                          |      4  2.8|
      Duct, Ectasia                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
      Acanthosis                           |                                                                          |      6  2.7|
      Erosion                              |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      2  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 8| 9| 9| 8| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      6  1.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Ulcer                                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Inflammation, Chronic Active  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Valve, Bacterium                     |                                                                          |      1     |
      Valve, Inflammation, Subacute        |                                                                          |      1  4.0|
      Valve, Thrombosis                    |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
      Capsule, Hyperplasia                 |                                                                          |     49  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Hyperplasia, Nodular                 |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Hyperplasia, Nodular                 |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  49        |
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
      Follicle, Cyst                       |                                                                          |      1     |
      Follicle, Hyperplasia, Nodular       |                                                                          |     14  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
      Duct, Dilatation                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Atrophy                              |                                                                          |      9  4.0|
      Cyst                                 |                                                                          |     20     |
      Hyperplasia, Tubular                 |                                                                          |      1  3.0|
      Bilateral, Atrophy                   |                                                                          |      3  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 8| 9| 9| 8| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Cyst                      |                                                                          |      4     |
      Bilateral, Hyperplasia, Tubular      |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     44  3.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Femoral, Myelofibrosis, Multifocal   |                                                                          |      1  2.0|
      Sternal, Myelofibrosis, Multifocal   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  48        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   6        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Sinus, Ectasia                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Depletion Lymphoid                   |                                                                          |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  44        |
      Inguinal, Hyperplasia, Cystic        |                                                                          |      4  2.5|
      Inguinal, Inflammation, Chronic      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Acanthosis                           |                                                                          |      4  1.3|
      Edema                                |                                                                          |      2  3.5|
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Inflammation, Necrotizing            |                                                                          |      1  1.0|
      Parasite Metazoan                    |                                                                          |      1     |
      Back, Acanthosis                     |                                                                          |      1  1.0|
      Back, Parasite Metazoan              |                                                                          |      1     |
      Scapula, Acanthosis                  |                                                                          |      4  1.3|
      Scapula, Hyperkeratosis              |                                                                          |      1  1.0|
      Scapula, Inflammation, Chronic       |                                                                          |      2  1.0|
      Scapula, Inflammation, Necrotizing   |                                                                          |      2  2.0|
      Scapula, Parasite Metazoan           |                                                                          |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 8| 9| 9| 8| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
      Subcutaneous Tissue, Necrosis,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Subcutaneous Tissue, Scapula,        |                                                                          |            |
          Necrosis, Multifocal             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Abdominal, Inflammation, Acute       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Hemorrhage, Multifocal               |                                                                          |      1  1.0|
      Mineralization, Multifocal           |                                                                          |     28  1.0|
      Hypothalamus, Compression            |                                                                          |      3  3.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion, Diffuse                  |                                                                          |      2  2.5|
      Hemorrhage, Multifocal               |                                                                          |      3  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  43        |
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Inflammation, Necrotizing            |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 2| 0| 9| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 1| 3| 0| 3| 3| 0| 0| 3| 3| 4|             
                                           | 7| 9| 8| 6| 9| 9| 6| 9| 9| 9| 9| 1| 9| 0| 0| 5| 0| 9| 0| 0| 4| 9| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Inclusion Body Intracytoplasmic      |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Thrombosis                           |                         X                                                |             
      Centrilobular, Degeneration, Hydropic|                                                                3         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                         +            |             
      Necrosis                             |                   3                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       1     1                                                            |             
      Duct, Ectasia                        |                   4                                                      |             
      Duct, Mineralization, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +                                                                  |             
      Aorta, Mineralization                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                3         |             
      Atrium Left, Thrombosis              |                                                                X         |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                            1                                             |             
      Valve, Bacterium                     | X     X  X                                                               |             
      Valve, Inflammation, Subacute        | 3        4                                                               |             
      Valve, Thrombosis                    | X     X  X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 1  2  2  1  3  2  2  2  2  1  3  2  3  2  3  2  3  2  3  3  2  2  3  3  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 2| 0| 9| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 1| 3| 0| 3| 3| 0| 0| 3| 3| 4|             
                                           | 7| 9| 8| 6| 9| 9| 6| 9| 9| 9| 9| 1| 9| 0| 0| 5| 0| 9| 0| 0| 4| 9| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Nodular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1                                         1      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Nodular  |                                     2                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Hyperplasia, Nodular       |                   2  2     3           1                    2        1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |                            4                 4                           |             
      Cyst                                 |       X     X  X     X        X  X  X     X  X        X        X         |             
      Hyperplasia, Tubular                 |    2                          3  4                                1      |             
      Necrosis, Acute                      |                   3                                                      |             
      Thrombosis                           |                                                                   X      |             
      Bilateral, Atrophy                   |    4  4     4  4  4  4  4     4  4  4  4  4     4  4  4  4  4  4  4  4   |             
      Bilateral, Cyst                      |    X                                   X        X        X  X            |             
      Bilateral, Hyperplasia, Tubular      |       2     1        2  1           2  1  3     1     2  2  2  2     1   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |    1  3     1     4     1  2  2  3  2  3  4  1  3  2  2  2     2  2  1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis, Multifocal   |                                                                          |             
      Femoral, Thrombosis                  |                                                                          |             
      Sternal, Myelofibrosis, Multifocal   |       2                                            1     2  2     2  1   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                    +           +         |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                1         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 2     2     3                                               2  4        3|             
      Hyperplasia, Lymphoid                |                                                       3                  |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 2| 0| 9| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 1| 3| 0| 3| 3| 0| 0| 3| 3| 4|             
                                           | 7| 9| 8| 6| 9| 9| 6| 9| 9| 9| 9| 1| 9| 0| 0| 5| 0| 9| 0| 0| 4| 9| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Inguinal, Hyperplasia, Cystic        |                2                                   1                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Back, Hyperkeratosis                 |       1                                                                  |             
      Scapula, Acanthosis                  |             1  1  1  1  1  1  1     1  2  1     1  1     1     1     1   |             
      Scapula, Hyperkeratosis              |       1     1  1  1              1     1     1     1     1  1     1  1  1|             
      Scapula, Inflammation, Chronic       |                                                 1                        |             
      Scapula, Inflammation, Necrotizing   |                                        1                                 |             
      Sebaceous Gland, Scapula, Hyperplasia|                                                                          |             
      Subcutaneous Tissue, Necrosis,       |                                                                          |             
          Multifocal                       |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |             1  1  1  1     1  1  1  1  1  1     1  1  1  1     1  1  1   |             
      Hypothalamus, Compression            |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Diffuse                  |          4                                                               |             
      Hemorrhage, Multifocal               | 2                                                                        |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Inflammation, Subacute       | 3                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 4| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 0| 3| 2| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 5| 5| 5|             
                                           | 1| 1| 1| 6| 9| 1| 2| 1| 1| 1| 1| 2| 5| 7| 2| 2| 2| 2| 2| 2| 7| 2| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Basophilic Focus                     |                      3                                                   |             
      Inclusion Body Intracytoplasmic      |                         1                             1                  |             
      Necrosis, Coagulative, Multifocal    |                                     2                                    |             
      Thrombosis                           |                                                                          |             
      Centrilobular, Degeneration, Hydropic|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +        +      |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A      |             
      Acinus, Atrophy                      |                            4                             3               |             
      Duct, Ectasia                        |                            4           4                                 |             
      Duct, Mineralization, Multifocal     |                                        2                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Cardiomyopathy                       |                                                                          |             
      Atrium Left, Thrombosis              |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Valve, Bacterium                     |                                                                          |             
      Valve, Inflammation, Subacute        |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Capsule, Hyperplasia                 | 2  2  3  2  2  3  2  3  3  3  3  2  2  2  3  2  4  2  2  2  1  2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 4| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 0| 3| 2| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 5| 5| 5|             
                                           | 1| 1| 1| 6| 9| 1| 2| 1| 1| 1| 1| 2| 5| 7| 2| 2| 2| 2| 2| 2| 7| 2| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Nodular                 | 2              2                                         2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Follicle, Hyperplasia, Nodular       | 2              1              2              1  1  1     1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Atrophy                              |          4  4        4           4     4  4  4     4     4               |             
      Cyst                                 | X  X  X  X  X        X     X           X  X        X  X                  |             
      Hyperplasia, Tubular                 | 2  1           1  1        1     2        3  3        1  1     1         |             
      Necrosis, Acute                      |                                  4                                       |             
      Thrombosis                           | X                                                                        |             
      Bilateral, Atrophy                   | 4  4  4        4  4     4  4  4                 4     4        4  4      |             
      Bilateral, Cyst                      |                                                                          |             
      Bilateral, Hyperplasia, Tubular      |       1  1           2  1     4                 1  2                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +      |             
      Endometrium, Hyperplasia, Cystic     | 2  1     2  2  3     3     2  3  2     1  2  2  2  2        4     1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Femoral, Myelofibrosis, Multifocal   | 1     1                                                                  |             
      Femoral, Thrombosis                  |          X                                                               |             
      Sternal, Myelofibrosis, Multifocal   |             2  2     2     1                    1  1                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +                                    |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Depletion Lymphoid                   |                                        3                    3            |             
      Hematopoietic Cell Proliferation     |                                     2                                    |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Thrombosis                           |          X                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 4| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 0| 3| 2| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 5| 5| 5|             
                                           | 1| 1| 1| 6| 9| 1| 2| 1| 1| 1| 1| 2| 5| 7| 2| 2| 2| 2| 2| 2| 7| 2| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  M      |             
      Inguinal, Hyperplasia, Cystic        |             2     1                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Back, Hyperkeratosis                 |                                                                          |             
      Scapula, Acanthosis                  | 1  1  1  1  1     1        1  1           1  1  1  1  1     1  1  2      |             
      Scapula, Hyperkeratosis              | 1  1     1  1     1        1     1  1           1  1        1  1  1      |             
      Scapula, Inflammation, Chronic       |                   1                                                      |             
      Scapula, Inflammation, Necrotizing   |    1                                      1                 1     2      |             
      Sebaceous Gland, Scapula, Hyperplasia|                                                    2                     |             
      Subcutaneous Tissue, Necrosis,       |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Mineralization, Multifocal           | 1  1  1     1  1     1  1  1  1  1        1  1  1  1  1  1  1  1         |             
      Hypothalamus, Compression            |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Congestion, Diffuse                  |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                        2                                 |             
      Artery, Inflammation, Subacute       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 5| 5| 5| 5| 5| 5| 2|                                            |            |
                                           | 8| 9| 1| 8| 9| 8| 8| 8| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +                    +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +                    +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +                    +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +                    +                                             |  50        |
      Basophilic Focus                     |                                                                          |      1  3.0|
      Inclusion Body Intracytoplasmic      |                                                                          |      2  1.0|
      Necrosis, Coagulative, Multifocal    |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
      Centrilobular, Degeneration, Hydropic|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +                    +                                             |  49        |
      Acinus, Atrophy                      |       1                                                                  |      5  2.0|
      Duct, Ectasia                        |                            4                                             |      4  4.0|
      Duct, Mineralization, Multifocal     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +                    +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +                    +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |       +                    +                                             |  50        |
      Cardiomyopathy                       |                                                                          |      1  3.0|
      Atrium Left, Thrombosis              |                                                                          |      1     |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  1.0|
      Valve, Bacterium                     |                                                                          |      3     |
      Valve, Inflammation, Subacute        |                                                                          |      2  3.5|
      Valve, Thrombosis                    |                                                                          |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 5| 5| 5| 5| 5| 5| 2|                                            |            |
                                           | 8| 9| 1| 8| 9| 8| 8| 8| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +                    +                                             |  50        |
      Capsule, Hyperplasia                 |       1                    2                                             |     50  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +                    +                                             |  50        |
      Hyperplasia, Nodular                 |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +                    +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +                    +                                             |  50        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       M                    M                                             |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +                    M                                             |  48        |
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +                    +                                             |  49        |
      Follicle, Hyperplasia, Nodular       |                                                                          |     13  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +                    +                                             |  49        |
      Atrophy                              |                                                                          |     11  4.0|
      Cyst                                 |                                                                          |     22     |
      Hyperplasia, Tubular                 |                                                                          |     15  1.8|
      Necrosis, Acute                      |                                                                          |      2  3.5|
      Thrombosis                           |                                                                          |      2     |
      Bilateral, Atrophy                   |                                                                          |     32  4.0|
      Bilateral, Cyst                      |                                                                          |      5     |
      Bilateral, Hyperplasia, Tubular      |                                                                          |     20  1.7|
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +                    +                                             |  49        |
      Endometrium, Hyperplasia, Cystic     |                            3                                             |     36  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +                    +                                             |  50        |
      Femoral, Myelofibrosis, Multifocal   |                                                                          |      2  1.0|
      Femoral, Thrombosis                  |                                                                          |      1     |
      Sternal, Myelofibrosis, Multifocal   |                                                                          |     12  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                    I                                             |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +                    I                                             |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +                                                                  |   4        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 5| 5| 5| 5| 5| 5| 2|                                            |            |
                                           | 8| 9| 1| 8| 9| 8| 8| 8| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +                    +                                             |  50        |
      Depletion Lymphoid                   |       2                    3                                             |      4  2.8|
      Hematopoietic Cell Proliferation     |                                                                          |      7  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +                    M                                             |  45        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +                    M                                             |  41        |
      Inguinal, Hyperplasia, Cystic        |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    |       +                    +                                             |  50        |
      Back, Hyperkeratosis                 |                                                                          |      1  1.0|
      Scapula, Acanthosis                  |                                                                          |     31  1.1|
      Scapula, Hyperkeratosis              |                            1                                             |     27  1.0|
      Scapula, Inflammation, Chronic       |                                                                          |      2  1.0|
      Scapula, Inflammation, Necrotizing   |                                                                          |      5  1.2|
      Sebaceous Gland, Scapula, Hyperplasia|                                                                          |      1  2.0|
      Subcutaneous Tissue, Necrosis,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +                    +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +                    +                                             |  50        |
      Mineralization, Multifocal           |                            1                                             |     36  1.0|
      Hypothalamus, Compression            |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +                    +                                             |  50        |
      Congestion, Diffuse                  |                                                                          |      1  4.0|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Artery, Inflammation, Subacute       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +                    +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 5| 5| 5| 5| 5| 5| 2|                                            |            |
                                           | 8| 9| 1| 8| 9| 8| 8| 8| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       M                    +                                             |  46        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +                    +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 6| 0| 7| 5| 7| 7| 7| 4| 4| 0| 5| 5| 7|             
                             DAY ON TEST   | 0| 7| 2| 0| 6| 2| 2| 2| 8| 0| 3| 7| 8| 0| 3| 7| 3| 1| 3| 9| 6| 4| 8| 7| 0|             
                                           | 2| 9| 9| 0| 6| 9| 9| 9| 4| 5| 0| 9| 9| 3| 0| 2| 0| 9| 0| 5| 4| 5| 4| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                         2|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                  1                                   1   |             
      Inclusion Body Intracytoplasmic      |                                           1                              |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                            1                    1  1                    1|             
      Necrosis, Coagulative, Multifocal    |                                                                   2     2|             
      Necrosis, Caseous, Multifocal        |          2                                                               |             
      Thrombosis                           |                                                                   X      |             
      Sinusoid, Centrilobular, Dilatation  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                +               |             
      Inflammation, Chronic                |                         2                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Inflammation, Chronic                |    3                                                                     |             
      Inflammation, Granulomatous          |                                                                          |             
      Acinus, Atrophy                      |       1                             1                                   1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Multifocal, Subacute   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Bacterium                     |                                                                          |             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
      Aorta, Thrombosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 6| 0| 7| 5| 7| 7| 7| 4| 4| 0| 5| 5| 7|             
                             DAY ON TEST   | 0| 7| 2| 0| 6| 2| 2| 2| 8| 0| 3| 7| 8| 0| 3| 7| 3| 1| 3| 9| 6| 4| 8| 7| 0|             
                                           | 2| 9| 9| 0| 6| 9| 9| 9| 4| 5| 0| 9| 9| 3| 0| 2| 0| 9| 0| 5| 4| 5| 4| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |          1                 1                                             |             
      Myocardium, Inflammation, Focal,     |                                                                          |             
           Subacute                        |                                                                         2|             
      Valve, Bacterium                     |                                                                          |             
      Valve, Thrombosis                    |                                                                         X|             
      Vein, Thrombosis                     |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Capsule, Hyperplasia      |                                                                          |             
      Capsule, Hyperplasia                 | 2  1  2  3  2  4  4  2  2  3  2  3  3  1  2  3  2  2  1  2  3  1  2  2  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       1                                                                  |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Nodular  |                                                                         1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                                                                     |             
      Follicle, Hyperplasia, Nodular       |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       4        4  4           4  4              4        4               |             
      Congestion                           |                                                                          |             
      Cyst                                 |       X     X  X        X  X  X  X                                X  X  X|             
      Hyperplasia, Tubular                 |    2  3     3  1  1                             1     3  3  2            |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bilateral, Atrophy                   | 4        4  4           4  4        4     4  4        4     4     4  4  3|             
      Bilateral, Cyst                      |          X                          X           X     X                  |             
      Bilateral, Hyperplasia, Tubular      | 1        2              2  3        2     3  2                    1     3|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     | 1  1  2     1  2     3  2  2  2  4  3     2     1  4  3  1        2     2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 6| 0| 7| 5| 7| 7| 7| 4| 4| 0| 5| 5| 7|             
                             DAY ON TEST   | 0| 7| 2| 0| 6| 2| 2| 2| 8| 0| 3| 7| 8| 0| 3| 7| 3| 1| 3| 9| 6| 4| 8| 7| 0|             
                                           | 2| 9| 9| 0| 6| 9| 9| 9| 4| 5| 0| 9| 9| 3| 0| 2| 0| 9| 0| 5| 4| 5| 4| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Mononuclear Cell                |                                  2                                       |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Polymorphonuclear               |                                                    1                     |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Polymorphonuclear               |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                    +  +  +                                         +|             
      Hematopoietic Cell Proliferation     |    2                                                                     |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                         2|             
      Depletion Lymphoid                   |                                        3                    3  2         |             
      Hematopoietic Cell Proliferation     | 3  1  4  4  2  3           4     3        1                       4  4  3|             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  M  M  +  +  +  M  +  +  +  M  +  +  +  M  +  M  M  +  +  +  M  M|             
      Ectopic Thyroid                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +|             
      Inguinal, Hyperplasia, Cystic        |                                  3                 2                     |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                   1  1                             1                     |             
      Hyperkeratosis                       |                      1                             1     1               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Necrotizing            |       3                    3                                             |             
      Back, Acanthosis                     |                      1              1                 2                  |             
      Back, Hyperkeratosis                 |                      1              1                       1            |             
      Back, Inflammation, Necrotizing      |             1                                         3                 2|             
      Scapula, Acanthosis                  |    2  2  1  1  1  1  1  1  2  2     1     3  2  2  2  1     1     1     1|             
      Scapula, Hyperkeratosis              | 2     1  1  1     1  1  1     1     1     1  1        1     1           2|             
      Scapula, Inflammation, Necrotizing   | 2  2     1     3           3  3           3  1     2              1      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Humerus, Proliferation               |                                                       4                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                             +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 6| 0| 7| 5| 7| 7| 7| 4| 4| 0| 5| 5| 7|             
                             DAY ON TEST   | 0| 7| 2| 0| 6| 2| 2| 2| 8| 0| 3| 7| 8| 0| 3| 7| 3| 1| 3| 9| 6| 4| 8| 7| 0|             
                                           | 2| 9| 9| 0| 6| 9| 9| 9| 4| 5| 0| 9| 9| 3| 0| 2| 0| 9| 0| 5| 4| 5| 4| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           | 1  1  1  1  1           1  1  1  1  1        1        1           1  1   |             
      Hypothalamus, Compression            |                         4                          4                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Diffuse                  |                                                                2         |             
      Hemorrhage, Focal                    |                                                                1         |             
      Hemorrhage, Multifocal               |          2                                                           1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation, Subacute               |                         2                          2                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Inflammation, Multifocal, Subacute   |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Renal Tubule, Bacterium              |                                                                          |             
      Renal Tubule, Casts Protein,         |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Wall, Inflammation, Chronic          |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 5| 7| 0| 7| 4| 4| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 4| 6|             
                             DAY ON TEST   | 6| 3| 4| 3| 3| 2| 9| 2| 0| 2| 5| 3| 6| 3| 3| 8| 2| 2| 3| 6| 9| 7| 3| 9| 0|             
                                           | 9| 1| 8| 1| 0| 4| 4| 6| 4| 5| 2| 6| 6| 1| 2| 3| 6| 6| 2| 6| 8| 7| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis                          |                                                    3                     |             
      Cyst                                 |                                        X  X                              |             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Inclusion Body Intracytoplasmic      |    3                                                                     |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                      1                                      2            |             
      Necrosis, Coagulative, Multifocal    |       2                                                        3         |             
      Necrosis, Caseous, Multifocal        |                                                                          |             
      Thrombosis                           |       X           X                                X           X         |             
      Sinusoid, Centrilobular, Dilatation  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |       X                                                                  |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                                        3                                 |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Multifocal, Subacute   |                      2                                      1            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                    2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                     +                                   +|             
      Aorta, Bacterium                     |                                                                         X|             
      Aorta, Inflammation, Chronic Active  |                                     2                                    |             
      Aorta, Thrombosis                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 5| 7| 0| 7| 4| 4| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 4| 6|             
                             DAY ON TEST   | 6| 3| 4| 3| 3| 2| 9| 2| 0| 2| 5| 3| 6| 3| 3| 8| 2| 2| 3| 6| 9| 7| 3| 9| 0|             
                                           | 9| 1| 8| 1| 0| 4| 4| 6| 4| 5| 2| 6| 6| 1| 2| 3| 6| 6| 2| 6| 8| 7| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                 1                        |             
      Myocardium, Inflammation, Focal,     |                                                                          |             
           Subacute                        |                                                                          |             
      Valve, Bacterium                     |                                                             X            |             
      Valve, Thrombosis                    |                                                             X            |             
      Vein, Thrombosis                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Capsule, Hyperplasia      | 2                                                                        |             
      Capsule, Hyperplasia                 |    4  3  3  4  2  2  2        2  2  2  2  4  2  2  2  3  3  3  2  3  3  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Nodular                 |                                     1                                    |             
      Inflammation, Subacute               |                      1                                      2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        1                    1            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Nodular  |                                        1                    3  1         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Follicle, Hyperplasia, Nodular       |          2     3                             3  1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      4           4     4  4     4     4                  |             
      Congestion                           |                                                                      3   |             
      Cyst                                 |                   X  X                       X  X  X                    X|             
      Hyperplasia, Tubular                 |       3     3        2           1     2        4     2              2   |             
      Infiltration Cellular, Lymphocyte    |                4                                                         |             
      Thrombosis                           |                X                                                         |             
      Bilateral, Atrophy                   | 4  4  4  4  4     4        4  4     4        4     4     4  4  4     4  4|             
      Bilateral, Cyst                      | X        X  X                       X     X              X               |             
      Bilateral, Hyperplasia, Tubular      |          3        2        3  2     3     2  2     1     3  2  2        3|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     | 1     2  2  2     2  3     2  1     3  3  4  1  2  1  1     2  1  4  2  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 5| 7| 0| 7| 4| 4| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 4| 6|             
                             DAY ON TEST   | 6| 3| 4| 3| 3| 2| 9| 2| 0| 2| 5| 3| 6| 3| 3| 8| 2| 2| 3| 6| 9| 7| 3| 9| 0|             
                                           | 9| 1| 8| 1| 0| 4| 4| 6| 4| 5| 2| 6| 6| 1| 2| 3| 6| 6| 2| 6| 8| 7| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                       4                  |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Mononuclear Cell                |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Polymorphonuclear               |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Polymorphonuclear               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                         +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                         2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                         2|             
      Depletion Lymphoid                   |                         2                                                |             
      Hematopoietic Cell Proliferation     |       2     2  3  2  4     2  3  4           4  4  2     2  4  3  3     2|             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Ectopic Thyroid                      |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +|             
      Inguinal, Hyperplasia, Cystic        |                                                             2            |             
      Inguinal, Inflammation, Chronic      |                                                                         2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |       1                             1                                    |             
      Hyperkeratosis                       |       1        1                                                         |             
      Inflammation, Chronic                | 2              1                    2                                    |             
      Inflammation, Necrotizing            |             3        2                       3                          4|             
      Back, Acanthosis                     |                                                    2              2      |             
      Back, Hyperkeratosis                 |                                                    1                     |             
      Back, Inflammation, Necrotizing      |                                                    1              3      |             
      Scapula, Acanthosis                  | 1  2  2  2  1  3  1  1        1  1  1  2  2  2  1     1  1  1  2  2  1  3|             
      Scapula, Hyperkeratosis              | 1        1     1  1  1     1  1  1  1           1        1  1  1     1  1|             
      Scapula, Inflammation, Necrotizing   |                                           1  3                 2  1     3|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Humerus, Proliferation               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 5| 7| 0| 7| 4| 4| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 4| 6|             
                             DAY ON TEST   | 6| 3| 4| 3| 3| 2| 9| 2| 0| 2| 5| 3| 6| 3| 3| 8| 2| 2| 3| 6| 9| 7| 3| 9| 0|             
                                           | 9| 1| 8| 1| 0| 4| 4| 6| 4| 5| 2| 6| 6| 1| 2| 3| 6| 6| 2| 6| 8| 7| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |    1  1  1                 1           1  1     1     1     1     1      |             
      Hypothalamus, Compression            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Diffuse                  |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  I  +  +  I  +  +  +  +  +  +  I  +  +  I  M  +|             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                2                                                         |             
      Inflammation, Multifocal, Subacute   |                                                             2            |             
      Inflammation, Necrotizing            |                4                                                         |             
      Renal Tubule, Bacterium              |                X                                                         |             
      Renal Tubule, Casts Protein,         |                                                                          |             
          Multifocal                       |                                  1                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Wall, Inflammation, Chronic          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 9| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.3|
      Inclusion Body Intracytoplasmic      |                                                                          |      2  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      6  1.2|
      Necrosis, Coagulative, Multifocal    |                                                                          |      4  2.3|
      Necrosis, Caseous, Multifocal        |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      5     |
      Sinusoid, Centrilobular, Dilatation  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Ectopic Tissue                       |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Inflammation, Multifocal, Subacute   |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Aorta, Bacterium                     |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 9| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Aorta, Inflammation, Chronic Active  |                                                                          |      1  2.0|
      Aorta, Thrombosis                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  1.0|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      3  1.0|
      Myocardium, Inflammation, Focal,     |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
      Valve, Bacterium                     |                                                                          |      1     |
      Valve, Thrombosis                    |                                                                          |      2     |
      Vein, Thrombosis                     |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
      Bilateral, Capsule, Hyperplasia      |                                                                          |      1  2.0|
      Capsule, Hyperplasia                 |                                                                          |     47  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia, Nodular                 |                                                                          |      1  1.0|
      Inflammation, Subacute               |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  47        |
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Cyst                                 |                                                                          |      1     |
      Follicle, Hyperplasia, Nodular       |                                                                          |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  49        |
      Atrophy                              |                                                                          |     13  4.0|
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |     16     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 9| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Tubular                 |                                                                          |     17  2.2|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1     |
      Bilateral, Atrophy                   |                                                                          |     29  4.0|
      Bilateral, Cyst                      |                                                                          |     10     |
      Bilateral, Hyperplasia, Tubular      |                                                                          |     21  2.2|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  49        |
      Endometrium, Hyperplasia, Cystic     |                                                                          |     38  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  47        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  4.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Mononuclear Cell                |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Polymorphonuclear               |                                                                          |      1  1.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Polymorphonuclear               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  47        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   6        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Amyloid Deposition                   |                                                                          |      2  2.0|
      Depletion Lymphoid                   |                                                                          |      4  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |     28  2.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  33        |
      Ectopic Thyroid                      |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  41        |
      Inguinal, Hyperplasia, Cystic        |                                                                          |      3  2.3|
      Inguinal, Inflammation, Chronic      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Acanthosis                           |                                                                          |      5  1.0|
      Hyperkeratosis                       |                                                                          |      5  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 9| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      3  1.7|
      Inflammation, Necrotizing            |                                                                          |      6  3.0|
      Back, Acanthosis                     |                                                                          |      5  1.6|
      Back, Hyperkeratosis                 |                                                                          |      4  1.0|
      Back, Inflammation, Necrotizing      |                                                                          |      5  2.0|
      Scapula, Acanthosis                  |                                                                          |     41  1.5|
      Scapula, Hyperkeratosis              |                                                                          |     29  1.1|
      Scapula, Inflammation, Necrotizing   |                                                                          |     15  2.1|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  49        |
      Humerus, Proliferation               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Mineralization, Multifocal           |                                                                          |     24  1.0|
      Hypothalamus, Compression            |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion, Diffuse                  |                                                                          |      1  2.0|
      Hemorrhage, Focal                    |                                                                          |      1  1.0|
      Hemorrhage, Multifocal               |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  42        |
      Inflammation, Subacute               |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      1  2.0|
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
      Renal Tubule, Bacterium              |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 9| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Casts Protein,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  48        |
      Wall, Inflammation, Chronic          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 5| 1| 5| 5| 5| 4| 3| 5| 5|             
                             DAY ON TEST   | 3| 0| 7| 4| 7| 3| 5| 4| 6| 9| 9| 3| 5| 7| 6| 6| 4| 8| 9| 9| 9| 7| 8| 9| 5|             
                                           | 2| 3| 4| 9| 6| 5| 8| 1| 2| 3| 3| 5| 0| 8| 2| 4| 1| 6| 3| 3| 3| 4| 8| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Basophilic Focus                     |                                  2                                       |             
      Hematopoietic Cell Proliferation     |                                  2           3                           |             
      Inclusion Body Intracytoplasmic      |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       | 1              1                    3                                    |             
      Necrosis, Coagulative, Multifocal    |                         3  1     2                 1           1  3      |             
      Thrombosis                           |                                                                X         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                                          |             
      Acinus, Atrophy                      |                                                                         1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               1                          3               |             
      Inflammation, Chronic Active         |                                                          2               |             
      Ulcer                                |                                                       1              1  1|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                            1                 2                           |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Gingiva, Abscess                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                           +        +                     |             
      Aorta, Bacterium                     |                                           X        X                     |             
      Aorta, Inflammation, Chronic Active  |                                           4        4                     |             
      Aorta, Thrombosis                    |                                           X        X                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Focal,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 5| 1| 5| 5| 5| 4| 3| 5| 5|             
                             DAY ON TEST   | 3| 0| 7| 4| 7| 3| 5| 4| 6| 9| 9| 3| 5| 7| 6| 6| 4| 8| 9| 9| 9| 7| 8| 9| 5|             
                                           | 2| 3| 4| 9| 6| 5| 8| 1| 2| 3| 3| 5| 0| 8| 2| 4| 1| 6| 3| 3| 3| 4| 8| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
           Subacute                        |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Hyperplasia               |                                     3                                    |             
      Capsule, Hyperplasia                 | 2  2  2  2  1  2  2  3  1  2  3  1        2  2  2  2  2  2  2  2  2     2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                   X                                                      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Nodular                 |                                        2                             1   |             
      Inflammation, Chronic                |                2                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  I  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Nodular  |                            2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                4     4     4     4           4           4  4            |             
      Cyst                                 |                   X  X  X  X        X  X  X                          X  X|             
      Hemorrhage                           |                                                                   4      |             
      Hyperplasia, Tubular                 | 3           3  3  2           4  2  2                 2           1  2   |             
      Bilateral, Atrophy                   | 4  4  4  3  4     4     4     4     4  4  2     4  4  4        4  4  4  4|             
      Bilateral, Cyst                      | 2                             X                 X           X            |             
      Bilateral, Hyperplasia, Tubular      |                                        3     2  2           2  1        2|             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Subacute                        |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Fibrosis                |                            2                                             |             
      Endometrium, Hyperplasia, Cystic     |    2  1     2              3  2           2              4     2  3  2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis, Multifocal   |                            3                                            1|             
      Femoral, Necrosis, Caseous           |                                                                          |             
      Sternal, Myelofibrosis, Multifocal   |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 5| 1| 5| 5| 5| 4| 3| 5| 5|             
                             DAY ON TEST   | 3| 0| 7| 4| 7| 3| 5| 4| 6| 9| 9| 3| 5| 7| 6| 6| 4| 8| 9| 9| 9| 7| 8| 9| 5|             
                                           | 2| 3| 4| 9| 6| 5| 8| 1| 2| 3| 3| 5| 0| 8| 2| 4| 1| 6| 3| 3| 3| 4| 8| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +                                   +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                     4                                   1|             
      Sinus, Ectasia                       |                                                                         3|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                             2            |             
      Depletion Lymphoid                   | 3                                                                        |             
      Hematopoietic Cell Proliferation     |    4     4  4  4  1     3  2     3  4  4     4  4        4  2     3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  M  +  M  +  M  M  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  M  M  +  +  +  +  +  +  M|             
      Cervical, Atypia Cytologic           |                                                          3               |             
      Inguinal, Hyperplasia, Cystic        |    3  1                    2                             2  2            |             
      Inguinal, Inflammation, Acute        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Acanthosis                           |                      1                                            2      |             
      Hyperkeratosis                       |                      1                                            1      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Necrotizing            |                                  3                    2                  |             
      Back, Acanthosis                     |                   2              2                                       |             
      Back, Hyperkeratosis                 |                                                                          |             
      Back, Inflammation, Necrotizing      |                                  3                                       |             
      Scapula, Abscess                     |                                                             3        3   |             
      Scapula, Acanthosis                  | 1  2  3  1     1     2  2  3  1     2  2     2  3  1  2  2  2  1     2  2|             
      Scapula, Hyperkeratosis              | 1        1           2  1  1  1              1     1     2     1     1  2|             
      Scapula, Inflammation, Necrotizing   | 2     3           4  3     1     2  2           3     4     2        3  3|             
      Subcutaneous Tissue, Fibrosis        |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           | 1                 1  1        1  1     1     1  1           1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 5| 1| 5| 5| 5| 4| 3| 5| 5|             
                             DAY ON TEST   | 3| 0| 7| 4| 7| 3| 5| 4| 6| 9| 9| 3| 5| 7| 6| 6| 4| 8| 9| 9| 9| 7| 8| 9| 5|             
                                           | 2| 3| 4| 9| 6| 5| 8| 1| 2| 3| 3| 5| 0| 8| 2| 4| 1| 6| 3| 3| 3| 4| 8| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multifocal               |                                           3        1                     |             
      Inflammation, Focal, Suppurative     |                                     2                                    |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                     2                                    |             
      Artery, Inflammation, Subacute       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Inflammation, Acute          |                            2                                             |             
      Nerve, Nares, Inflammation, Subacute |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Necrotizing            |             1                                                            |             
      Inflammation, Subacute               |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Multifocal, Subacute   |                                     2        2                           |             
      Inflammation, Necrotizing            |                                                                          |             
      Renal Tubule, Bacterium              |                                                                          |             
      Renal Tubule, Casts Protein,         |                                                                          |             
          Multifocal                       |                                              2                           |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                                              1                           |             
      Renal Tubule, Necrosis, Coagulative, |                                                                          |             
           Multifocal                      |                                                                   2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 5| 5| 4| 5| 0| 5| 5| 5| 4| 5| 4| 5|             
                             DAY ON TEST   | 8| 7| 4| 9| 5| 7| 7| 1| 9| 4| 0| 5| 2| 9| 9| 9| 2| 0| 9| 7| 7| 3| 9| 9| 9|             
                                           | 7| 9| 4| 3| 8| 9| 9| 9| 9| 4| 7| 0| 3| 3| 3| 9| 3| 2| 3| 8| 9| 1| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                 4                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                 4                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                   2      |             
      Basophilic Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inclusion Body Intracytoplasmic      |                                                       1                  |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |    2                                                              1      |             
      Necrosis, Coagulative, Multifocal    | 2                    2                                                   |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           | 4                                                                        |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
      Inflammation, Acute                  |    2                                                     1               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                             +            |             
      Gingiva, Abscess                     |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Bacterium                     |                                                                          |             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
      Aorta, Thrombosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Focal,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 5| 5| 4| 5| 0| 5| 5| 5| 4| 5| 4| 5|             
                             DAY ON TEST   | 8| 7| 4| 9| 5| 7| 7| 1| 9| 4| 0| 5| 2| 9| 9| 9| 2| 0| 9| 7| 7| 3| 9| 9| 9|             
                                           | 7| 9| 4| 3| 8| 9| 9| 9| 9| 4| 7| 0| 3| 3| 3| 9| 3| 2| 3| 8| 9| 1| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
           Subacute                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Hyperplasia               |                                                                          |             
      Capsule, Hyperplasia                 | 3  2  2  2  3  3  2  2  2  1  2  1  2  3  2  2  2  1  2  1  2  3  2  4  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Hyperplasia, Nodular  |       1                                                              1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4                                                                     |             
      Cyst                                 |       X                    X        X  X        X        X        X      |             
      Hemorrhage                           |                                     3                                    |             
      Hyperplasia, Tubular                 |                1                    4                    2               |             
      Bilateral, Atrophy                   | 4     4  4  4  4  4  4  4  4  4  4  4        4  4     4  4  4  4  4  4  4|             
      Bilateral, Cyst                      |    X              X                       X                 X  X        X|             
      Bilateral, Hyperplasia, Tubular      | 2  2  2     1     3     4  2  1  3           1  2     2     2     2     2|             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Subacute                        |    4                                                                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    4                                                                     |             
      Endometrium, Fibrosis                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 1     1           4  2     2     1     1  2                       2     1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis, Multifocal   |                                                                          |             
      Femoral, Necrosis, Caseous           |                                                          4               |             
      Sternal, Myelofibrosis, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 5| 5| 4| 5| 0| 5| 5| 5| 4| 5| 4| 5|             
                             DAY ON TEST   | 8| 7| 4| 9| 5| 7| 7| 1| 9| 4| 0| 5| 2| 9| 9| 9| 2| 0| 9| 7| 7| 3| 9| 9| 9|             
                                           | 7| 9| 4| 3| 8| 9| 9| 9| 9| 4| 7| 0| 3| 3| 3| 9| 3| 2| 3| 8| 9| 1| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Polymorphonuclear                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +                 +           +  +                                 |             
      Hematopoietic Cell Proliferation     |                                     2                                    |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |    3                                                                     |             
      Sinus, Ectasia                       |                                     4                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                   1      |             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 3  4  3  4  4  3  2        3        3        4  2        2  4  2  3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  M  +  M  +  M  +  M  +  +  +  M  +  +  +  M  +  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  I  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Cervical, Atypia Cytologic           |                                                                          |             
      Inguinal, Hyperplasia, Cystic        |       2  1        2                                   4                  |             
      Inguinal, Inflammation, Acute        |                                                 2                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                             3            |             
      Acanthosis                           |       1  1                                                               |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                             3            |             
      Inflammation, Necrotizing            |    3  3  3  3                                                            |             
      Back, Acanthosis                     |                                        1              1                  |             
      Back, Hyperkeratosis                 |       1                                               1                  |             
      Back, Inflammation, Necrotizing      |                                                                          |             
      Scapula, Abscess                     |                                                                          |             
      Scapula, Acanthosis                  | 2  2  2  2  2     3     2  1  1  2        2  1        2  1     3     1   |             
      Scapula, Hyperkeratosis              | 2           1           1  1  1        1     1           1               |             
      Scapula, Inflammation, Necrotizing   |    3              2                                   3        2         |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           | 1              1        1     1  1     1  1           1  1  1  1        1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 5| 5| 4| 5| 0| 5| 5| 5| 4| 5| 4| 5|             
                             DAY ON TEST   | 8| 7| 4| 9| 5| 7| 7| 1| 9| 4| 0| 5| 2| 9| 9| 9| 2| 0| 9| 7| 7| 3| 9| 9| 9|             
                                           | 7| 9| 4| 3| 8| 9| 9| 9| 9| 4| 7| 0| 3| 3| 3| 9| 3| 2| 3| 8| 9| 1| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multifocal               |                                                                          |             
      Inflammation, Focal, Suppurative     |    3                                                                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                         1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Artery, Inflammation, Subacute       |                                                                         2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Inflammation, Acute          |                                                                          |             
      Nerve, Nares, Inflammation, Subacute |                         3                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                   1                                                      |             
      Inflammation, Necrotizing            |                                                                          |             
      Inflammation, Subacute               |    3                    3                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Multifocal, Subacute   |                                                                          |             
      Inflammation, Necrotizing            |                                                             4            |             
      Renal Tubule, Bacterium              |                                                             X            |             
      Renal Tubule, Casts Protein,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Renal Tubule, Necrosis, Coagulative, |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 9| 9| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Inclusion Body Intracytoplasmic      |                                                                          |      1  1.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      5  1.6|
      Necrosis, Coagulative, Multifocal    |                                                                          |      8  1.9|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Hypoplasia                           |                                                                          |      1  4.0|
      Acinus, Atrophy                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Necrosis, Coagulative                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Acanthosis                           |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Gingiva, Abscess                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 9| 9| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Aorta, Bacterium                     |                                                                          |      2     |
      Aorta, Inflammation, Chronic Active  |                                                                          |      2  4.0|
      Aorta, Thrombosis                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Myocardium, Inflammation, Focal,     |                                                                          |            |
           Subacute                        |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
      Bilateral, Hyperplasia               |                                                                          |      1  3.0|
      Capsule, Hyperplasia                 |                                                                          |     47  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  49        |
      Ectopic Tissue                       |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Nodular                 |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  45        |
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Atrophy                              |                                                                          |      8  4.0|
      Cyst                                 |                                                                          |     16     |
      Hemorrhage                           |                                                                          |      2  3.5|
      Hyperplasia, Tubular                 |                                                                          |     13  2.4|
      Bilateral, Atrophy                   |                                                                          |     39  3.9|
      Bilateral, Cyst                      |                                                                          |     10  2.0|
      Bilateral, Hyperplasia, Tubular      |                                                                          |     21  2.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Subacute                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 9| 9| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Endometrium, Fibrosis                |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     21  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Femoral, Myelofibrosis, Multifocal   |                                                                          |      2  2.0|
      Femoral, Necrosis, Caseous           |                                                                          |      1  4.0|
      Sternal, Myelofibrosis, Multifocal   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Renal, Infiltration Cellular,        |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  48        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   7        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      3  2.7|
      Sinus, Ectasia                       |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Amyloid Deposition                   |                                                                          |      2  1.5|
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |     30  3.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  33        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  39        |
      Cervical, Atypia Cytologic           |                                                                          |      1  3.0|
      Inguinal, Hyperplasia, Cystic        |                                                                          |      9  2.1|
      Inguinal, Inflammation, Acute        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Abscess                              |                                                                          |      1  3.0|
      Acanthosis                           |                                                                          |      4  1.3|
      Hyperkeratosis                       |                                                                          |      2  1.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Necrotizing            |                                                                          |      6  2.8|
      Back, Acanthosis                     |                                                                          |      4  1.5|
      Back, Hyperkeratosis                 |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 9| 9| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Back, Inflammation, Necrotizing      |                                                                          |      1  3.0|
      Scapula, Abscess                     |                                                                          |      2  3.0|
      Scapula, Acanthosis                  |                                                                          |     36  1.8|
      Scapula, Hyperkeratosis              |                                                                          |     20  1.2|
      Scapula, Inflammation, Necrotizing   |                                                                          |     16  2.6|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Mineralization, Multifocal           |                                                                          |     24  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Hemorrhage, Multifocal               |                                                                          |      2  2.0|
      Inflammation, Focal, Suppurative     |                                                                          |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Artery, Inflammation, Subacute       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Glands, Inflammation, Acute          |                                                                          |      1  2.0|
      Nerve, Nares, Inflammation, Subacute |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  45        |
      Hyperplasia, Nodular                 |                                                                          |      1  1.0|
      Inflammation, Necrotizing            |                                                                          |      1  1.0|
      Inflammation, Subacute               |                                                                          |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Inflammation, Multifocal, Subacute   |                                                                          |      2  2.0|
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
      Renal Tubule, Bacterium              |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 9| 9| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Casts Protein,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Renal Tubule, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Renal Tubule, Necrosis, Coagulative, |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Inflammation, Acute                  |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7|             
                                           | 9| 5| 7| 9| 9| 9| 9| 9| 9| 9| 4| 0| 8| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X        X                                                      |             
      Cytomegaly, Multifocal               |                                                 2                        |             
      Inclusion Body Intracytoplasmic      |             2                                                            |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                 1                        |             
      Necrosis, Coagulative, Multifocal    |                                                                         2|             
      Thrombosis                           |             X           X                                X              X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Inflammation, Chronic                |                                                                2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                                                             1            |             
      Acinus, Atrophy                      |                               2                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        | 2                                                                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                  1                                       |             
      Hyperkeratosis                       |                                  1                                       |             
      Ulcer                                |          1              1                 1                              |             
      Lamina Propria, Infiltration         |                                                                          |             
          Cellular, Focal, Histiocyte      |                      2                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
      Serosa, Granuloma                    |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
      Peridontal Tissue, Molar, Abscess    |                                                                          |             
      Pulp, Molar, Inflammation, Chronic   |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7|             
                                           | 9| 5| 7| 9| 9| 9| 9| 9| 9| 9| 4| 0| 8| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Chronic                          | 1                                                                        |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                                                          |             
      Myocardium, Mineralization,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Pericardium, Ectopic Thyroid         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 3  2  2  3  2  3  2  2  2  2  2  2  2  2  2  3  2  3  2  3  3  2  2  2  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                               2  2     1  1  2  1     1     2     2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1        1  2        1  1     2           1     1      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Pars Distalis, Hyperplasia, Nodular  |                                  1                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Hyperplasia, Nodular       |          1     3  2        1           1        1  1                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                 +                    +     +        +  +         |             
      Abscess                              |       4                 3                    3                 3         |             
      Inflammation, Chronic                |                                                             3            |             
      Duct, Dilatation                     |                                                    4                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |             +                                                            |             
      Polychromasia                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Thrombosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7|             
                                           | 9| 5| 7| 9| 9| 9| 9| 9| 9| 9| 4| 0| 8| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             1                                                            |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                | 1                                                                        |             
      Infiltration Cellular, Histiocyte    |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |    3                                                                     |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |             2           2                                                |             
      Thrombosis                           |                                                                          |             
      Subcapsular, Infiltration Cellular,  |                                                                          |             
           Multifocal, Histiocyte          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  I  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  +  M  M  M  M  M  M  +  M  M  M  M  M  M  M  +  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                            1                                             |             
      Back, Parasite Metazoan              |                                                                          |             
      Scapula, Acanthosis                  |                                                          1               |             
      Scapula, Hyperkeratosis              |                                                                          |             
      Scapula, Inflammation, Necrotizing   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Proliferation               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multifocal               |                                                                          |             
      Mineralization, Multifocal           |       1        1                          1  1  1              1  1  1  1|             
      Hypothalamus, Compression            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Diffuse                  |                               3     2                                    |             
      Hemorrhage, Focal                    |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7|             
                                           | 9| 5| 7| 9| 9| 9| 9| 9| 9| 9| 4| 0| 8| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Focal, Suppurative     |                                           1                              |             
      Bronchiole, Edema, Diffuse           |                                     2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +|             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       | X                                                                        |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Necrotizing            |                                                                         2|             
      Fat, Infiltration Cellular, Focal,   |                                                                          |             
           Histiocyte                      |                      2                                                   |             
      Glomerulus, Inflammation,            |                                                                          |             
          Proliferative                    |             3                                                            |             
      Renal Tubule, Bacterium              |                                                                         X|             
      Renal Tubule, Casts Protein,         |                                                                          |             
          Multifocal                       |             3                                                            |             
      Renal Tubule, Cyst                   |                                                 2                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 4| 7| 7| 7| 7| 7| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 0| 3| 3|             
                                           | 1| 1| 1| 1| 1| 2| 1| 9| 1| 1| 1| 1| 2| 2| 2| 5| 5| 2| 2| 2| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                      X               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X                                                      |             
      Cytomegaly, Multifocal               |                                           1                              |             
      Inclusion Body Intracytoplasmic      |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Thrombosis                           |                X     X                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                         1                                                |             
      Hyperkeratosis                       |                         1                                                |             
      Ulcer                                |                                                                          |             
      Lamina Propria, Infiltration         |                                                                          |             
          Cellular, Focal, Histiocyte      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                      2                                                   |             
      Serosa, Granuloma                    |       3                                                                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +              +                                      +|             
      Peridontal Tissue, Molar, Abscess    |                   3                                                      |             
      Pulp, Molar, Inflammation, Chronic   |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 4| 7| 7| 7| 7| 7| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 0| 3| 3|             
                                           | 1| 1| 1| 1| 1| 2| 1| 9| 1| 1| 1| 1| 2| 2| 2| 5| 5| 2| 2| 2| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Chronic                          |                                                                          |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                1                                                         |             
      Myocardium, Mineralization,          |                                                                          |             
          Multifocal                       |       1                                                                  |             
      Pericardium, Ectopic Thyroid         |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |    3  2  2  2  1     2  2     2  2  2  2  2     2     2  2  3  2     2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 | 2           1        2  1  2     2  2  1  2        3  3  2  3  2     3  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1        1              1     1  2  1  2  2        1  2     1  1     2  2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +  +  +  +  +  M  +|             
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Hyperplasia, Nodular       |    1  2                                   2                    1     4   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +              +                    +                 +               |             
      Abscess                              |                   3                    3                                 |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Dilatation                     |    4              3                                      3               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                         +|             
      Dilatation                           |                                                                         4|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Polychromasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Thrombosis                  |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 4| 7| 7| 7| 7| 7| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 0| 3| 3|             
                                           | 1| 1| 1| 1| 1| 2| 1| 9| 1| 1| 1| 1| 2| 2| 2| 5| 5| 2| 2| 2| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +     +                                               +         |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                | 1                                                                        |             
      Sinus, Ectasia                       | 4     4                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                              3  3                 3      |             
      Fibrosis, Focal                      |                                                                         3|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Thrombosis                           |                X                                                         |             
      Subcapsular, Infiltration Cellular,  |                                                                          |             
           Multifocal, Histiocyte          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  M  M  M  +  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                        4                                 |             
      Inflammation, Chronic                |                                                                          |             
      Back, Parasite Metazoan              |                                                                      X   |             
      Scapula, Acanthosis                  |                                                                          |             
      Scapula, Hyperkeratosis              |          1                                                               |             
      Scapula, Inflammation, Necrotizing   |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Proliferation               |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multifocal               |                                                                1         |             
      Mineralization, Multifocal           | 1     1     1  2  1        1  1  1     1              1        1        2|             
      Hypothalamus, Compression            |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Diffuse                  |                                                 3                        |             
      Hemorrhage, Focal                    |             1  1                                                         |             
      Hemorrhage, Multifocal               |                                                       2           2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 4| 7| 7| 7| 7| 7| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 0| 3| 3|             
                                           | 1| 1| 1| 1| 1| 2| 1| 9| 1| 1| 1| 1| 2| 2| 2| 5| 5| 2| 2| 2| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Bronchiole, Edema, Diffuse           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  +  M  +  +  M  +  M  +  +  +  +  M  I  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                         2                 3                              |             
      Inflammation, Chronic, Focal         |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Hemorrhage, Multifocal               |    1                                                                     |             
      Hydronephrosis                       |                   4                                                      |             
      Inflammation, Necrotizing            |                                                                          |             
      Fat, Infiltration Cellular, Focal,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Glomerulus, Inflammation,            |                                                                          |             
          Proliferative                    |                                                                          |             
      Renal Tubule, Bacterium              |                                                                          |             
      Renal Tubule, Casts Protein,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Renal Tubule, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 8| 9| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Cyst                                 |                                                                          |      3     |
      Cytomegaly, Multifocal               |                                                                          |      2  1.5|
      Inclusion Body Intracytoplasmic      |                                                                          |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Necrosis, Coagulative, Multifocal    |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      6     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  49        |
      Hyperplasia, Nodular                 |                                                                          |      1  1.0|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Acanthosis                           |                                                                          |      2  1.0|
      Hyperkeratosis                       |                                                                          |      2  1.0|
      Ulcer                                |                                                                          |      3  1.0|
      Lamina Propria, Infiltration         |                                                                          |            |
          Cellular, Focal, Histiocyte      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Inflammation, Necrotizing            |                                                                          |      1  2.0|
      Serosa, Granuloma                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
      Peridontal Tissue, Molar, Abscess    |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 8| 9| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Pulp, Molar, Inflammation, Chronic   |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  1.0|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Myocardium, Mineralization,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Pericardium, Ectopic Thyroid         |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
      Capsule, Hyperplasia                 |                                                                          |     44  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Hyperplasia, Nodular                 |                                                                          |     27  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  48        |
      Hyperplasia                          |                                                                          |     22  1.4|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  43        |
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
      Follicle, Hyperplasia, Nodular       |                                                                          |     12  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  10        |
      Abscess                              |                                                                          |      6  3.2|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Duct, Dilatation                     |                                                                          |      4  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 8| 9| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Dilatation                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
      Infarct                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Polychromasia                        |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
      Femoral, Thrombosis                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   5        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  1.0|
      Sinus, Ectasia                       |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
      Depletion Lymphoid                   |                                                                          |      4  3.0|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Thrombosis                           |                                                                          |      1     |
      Subcapsular, Infiltration Cellular,  |                                                                          |            |
           Multifocal, Histiocyte          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  40        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Abscess                              |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Back, Parasite Metazoan              |                                                                          |      1     |
      Scapula, Acanthosis                  |                                                                          |      1  1.0|
      Scapula, Hyperkeratosis              |                                                                          |      1  1.0|
      Scapula, Inflammation, Necrotizing   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 8| 9| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Cranium, Proliferation               |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Hemorrhage, Multifocal               |                                                                          |      1  1.0|
      Mineralization, Multifocal           |                                                                          |     21  1.1|
      Hypothalamus, Compression            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion, Diffuse                  |                                                                          |      3  2.7|
      Hemorrhage, Focal                    |                                                                          |      2  1.0|
      Hemorrhage, Multifocal               |                                                                          |      2  2.0|
      Inflammation, Focal, Suppurative     |                                                                          |      1  1.0|
      Bronchiole, Edema, Diffuse           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  39        |
      Hyperplasia, Nodular                 |                                                                          |      2  2.5|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Ectopic Tissue                       |                                                                          |      1     |
      Hemorrhage, Multifocal               |                                                                          |      1  1.0|
      Hydronephrosis                       |                                                                          |      1  4.0|
      Inflammation, Necrotizing            |                                                                          |      1  2.0|
      Fat, Infiltration Cellular, Focal,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Glomerulus, Inflammation,            |                                                                          |            |
          Proliferative                    |                                                                          |      1  3.0|
      Renal Tubule, Bacterium              |                                                                          |      1     |
      Renal Tubule, Casts Protein,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Renal Tubule, Cyst                   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 8| 9| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Thrombosis                           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 0| 6| 7| 6| 5| 7| 7| 7| 6| 7| 5| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 9| 1| 2| 2| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 3| 5| 3| 2| 8|             
                                           | 9| 9| 9| 9| 9| 4| 4| 9| 9| 0| 0| 0| 0| 0| 4| 0| 8| 0| 0| 0| 0| 3| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Parasite Metazoan                    |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X        X              X               |             
      Inclusion Body Intracytoplasmic      |                                                                          |             
      Necrosis, Coagulative, Focal         |                                                                3         |             
      Necrosis, Coagulative, Multifocal    |                               2                                          |             
      Thrombosis                           |          X                    X                                          |             
      Vein, Dilatation, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |             1                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                +        +                                                |             
      Peridontal Tissue, Incisor,          |                                                                          |             
          Inflammation, Chronic            |                2                                                         |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Chronic            |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                         +|             
      Renal Artery, Inflammation, Chronic  |                                                                         3|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Thrombosis                   |                                                                         X|             
      Atrium Left, Dilatation              |                                                                          |             
      Atrium Left, Thrombosis              |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                   2     2|             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 0| 6| 7| 6| 5| 7| 7| 7| 6| 7| 5| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 9| 1| 2| 2| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 3| 5| 3| 2| 8|             
                                           | 9| 9| 9| 9| 9| 4| 4| 9| 9| 0| 0| 0| 0| 0| 4| 0| 8| 0| 0| 0| 0| 3| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Myocardium, Inflammation, Focal,     |                                                                          |             
           Subacute                        |                                                          1               |             
      Valve, Inflammation, Subacute        |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |    3     2  2  2     3  2     1  1  3  2  2  1     1  2  3  2  1  2  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 | 2        2  1  3     3  3  2     2  2     2  2     2     2  2  1  2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
      Hyperplasia                          |       1                                         1                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Hyperplasia, Nodular  |                            2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Hyperplasia, Nodular       |    2        2           2           1                    1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +  +                                      +        +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 0| 6| 7| 6| 5| 7| 7| 7| 6| 7| 5| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 9| 1| 2| 2| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 3| 5| 3| 2| 8|             
                                           | 9| 9| 9| 9| 9| 4| 4| 9| 9| 0| 0| 0| 0| 0| 4| 0| 8| 0| 0| 0| 0| 3| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                1         |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                       2                  |             
      Sinus, Ectasia                       |                                                       3                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                       2                  |             
      Depletion Lymphoid                   |                                        4                                 |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |    2              4           2                 1     1              3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  M  M  +  +  +|             
      Ectopic Parathyroid Gland            |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  +  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                            1                          1     1            |             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                                                       1                  |             
      Back, Acanthosis                     | 1              2                                2        1               |             
      Back, Hyperkeratosis                 |                   1                                                      |             
      Scapula, Acanthosis                  | 1  2     1              1  1  1  1  1        1        1  1  1  1  1  3   |             
      Scapula, Hyperkeratosis              | 1              1                                      1        1     2   |             
      Scapula, Inflammation, Chronic       |                                                                          |             
      Scapula, Inflammation, Necrotizing   |    2                                                                 2   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |             1  1        1  1     1  1        1        1     1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                         1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +     +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 0| 6| 7| 6| 5| 7| 7| 7| 6| 7| 5| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 9| 1| 2| 2| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 3| 5| 3| 2| 8|             
                                           | 9| 9| 9| 9| 9| 4| 4| 9| 9| 0| 0| 0| 0| 0| 4| 0| 8| 0| 0| 0| 0| 3| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 0| 3|             
                                           | 3| 0| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 1| 2| 2| 2| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inclusion Body Intracytoplasmic      |                                     2                                    |             
      Necrosis, Coagulative, Focal         |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                                                 3  2     2               |             
      Thrombosis                           |                                                                          |             
      Vein, Dilatation, Focal              |             1                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                            4                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                         +                                                |             
      Peridontal Tissue, Incisor,          |                                                                          |             
          Inflammation, Chronic            |                         3                                                |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Chronic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Renal Artery, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Thrombosis                   |                                                                          |             
      Atrium Left, Dilatation              |          4                                                               |             
      Atrium Left, Thrombosis              |          X                                                               |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 0| 3|             
                                           | 3| 0| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 1| 2| 2| 2| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Myocardium, Inflammation, Focal,     |                                                                          |             
           Subacute                        |                                                                          |             
      Valve, Inflammation, Subacute        |                                                       1                  |             
      Valve, Thrombosis                    |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |    3  2  2  2  3     2  2  3  2  2  2  3  2  3  2  2  3  3  2  3  3     3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |       2     2  2        2  1  2        1     1        3     2  2  2  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                3         |             
      Hyperplasia                          |    1           2                                   3                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                               3                                          |             
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                                                                   2      |             
      Inflammation, Chronic                |                            3                                             |             
      Follicle, Hyperplasia, Nodular       | 2                                         2        3                 2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                 2                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                  +  +                 +     +            |             
      Abscess                              |                                     3                 3     3            |             
      Inflammation, Chronic                |                                  1                                       |             
      Duct, Dilatation                     |                                  3                                       |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +                          +                       +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 0| 3|             
                                           | 3| 0| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 1| 2| 2| 2| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Depletion Lymphoid                   |                   4                                                      |             
      Fibrosis, Focal                      |                                                                   1      |             
      Hematopoietic Cell Proliferation     | 4                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Ectopic Parathyroid Gland            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  +  M  +  M  M  M  +  M  M  M  +  M  M  M  +  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                  1                       1               |             
      Edema                                | 3                                                                        |             
      Hyperkeratosis                       |                                                                          |             
      Back, Acanthosis                     |                                     2                    1               |             
      Back, Hyperkeratosis                 |                                                                          |             
      Scapula, Acanthosis                  | 2     1     1  1     1  1  1  1  1  2  1  1  1     1  1  2  3  1  1     1|             
      Scapula, Hyperkeratosis              | 2     1        1     1           1                             1        1|             
      Scapula, Inflammation, Chronic       |                      1                                                   |             
      Scapula, Inflammation, Necrotizing   | 1                                                        2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           | 1  1  1  1  1  1     1  1  1  1  1  1  1     1           1  1        1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          1                                                               |             
      Interstitium, Inflammation, Chronic  |          1                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M     +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 0| 3|             
                                           | 3| 0| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 1| 2| 2| 2| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              | 3                                                        1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 8| 8| 9| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  48        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Cyst                                 |                                                                          |      3     |
      Inclusion Body Intracytoplasmic      |                                                                          |      1  2.0|
      Necrosis, Coagulative, Focal         |                                                                          |      1  3.0|
      Necrosis, Coagulative, Multifocal    |                                                                          |      4  2.3|
      Thrombosis                           |                                                                          |      2     |
      Vein, Dilatation, Focal              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Acinus, Atrophy                      |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
      Peridontal Tissue, Incisor,          |                                                                          |            |
          Inflammation, Chronic            |                                                                          |      2  2.5|
      Peridontal Tissue, Molar,            |                                                                          |            |
          Inflammation, Chronic            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Renal Artery, Inflammation, Chronic  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Artery, Thrombosis                   |                                                                          |      1     |
      Atrium Left, Dilatation              |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 8| 8| 9| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Atrium Left, Thrombosis              |                                                                          |      1     |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      2  2.0|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Myocardium, Inflammation, Focal,     |                                                                          |            |
           Subacute                        |                                                                          |      1  1.0|
      Valve, Inflammation, Subacute        |                                                                          |      1  1.0|
      Valve, Thrombosis                    |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
      Capsule, Hyperplasia                 |                                                                          |     42  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  49        |
      Hyperplasia, Nodular                 |                                                                          |     30  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
      Cytoplasmic Alteration               |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  47        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Hyperplasia, Nodular                 |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Follicle, Hyperplasia, Nodular       |                                                                          |      9  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  50        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   4        |
      Abscess                              |                                                                          |      3  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 8| 8| 9| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   8        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  2.0|
      Sinus, Ectasia                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Depletion Lymphoid                   |                                                                          |      2  4.0|
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      7  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  42        |
      Ectopic Parathyroid Gland            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  11        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Acanthosis                           |                                                                          |      5  1.0|
      Edema                                |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Back, Acanthosis                     |                                                                          |      6  1.5|
      Back, Hyperkeratosis                 |                                                                          |      1  1.0|
      Scapula, Acanthosis                  |                                                                          |     35  1.2|
      Scapula, Hyperkeratosis              |                                                                          |     12  1.2|
      Scapula, Inflammation, Chronic       |                                                                          |      1  1.0|
      Scapula, Inflammation, Necrotizing   |                                                                          |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 8| 8| 9| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Mineralization, Multifocal           |                                                                          |     30  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  42        |
      Hyperplasia, Nodular                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Infarct                              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 6| 7| 7| 7| 6| 6| 4| 5| 7| 6| 6| 6| 6| 6| 0| 6| 7| 6| 6| 6| 0|             
                             DAY ON TEST   | 6| 8| 9| 1| 5| 1| 2| 2| 8| 3| 3| 2| 1| 4| 0| 7| 8| 9| 0| 7| 0| 9| 8| 1| 0|             
                                           | 4| 7| 6| 1| 2| 1| 9| 6| 9| 5| 6| 7| 1| 3| 4| 8| 7| 5| 4| 2| 7| 8| 8| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Cyst                                 | X                                                                        |             
      Inclusion Body Intracytoplasmic      |                2                                                         |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                2     2                          3                        |             
      Necrosis, Coagulative, Focal         |                                                                      2   |             
      Necrosis, Coagulative, Multifocal    |                                           2              4               |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                      2                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Multifocal, Subacute   |                                                 2                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Bacterium                     |                                                                          |             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
      Aorta, Thrombosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Mineralization,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Valve, Bacterium                     |                                                                          |             
      Valve, Inflammation, Subacute        |                                                                          |             
      Valve, Thrombosis                    |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 3  1     1     2  2     2  1     1  2     2  1     1     1  3  2  3  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 6| 7| 7| 7| 6| 6| 4| 5| 7| 6| 6| 6| 6| 6| 0| 6| 7| 6| 6| 6| 0|             
                             DAY ON TEST   | 6| 8| 9| 1| 5| 1| 2| 2| 8| 3| 3| 2| 1| 4| 0| 7| 8| 9| 0| 7| 0| 9| 8| 1| 0|             
                                           | 4| 7| 6| 1| 2| 1| 9| 6| 9| 5| 6| 7| 1| 3| 4| 8| 7| 5| 4| 2| 7| 8| 8| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Nodular          |                            2                                             |             
      Hyperplasia, Nodular                 |       1                                                                  |             
      Necrosis, Liquifactive               |                                                 4                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Necrosis, Liquifactive               |                                                 4                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1                                   1            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |             1                                                            |             
      Follicle, Hyperplasia, Nodular       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                      2                          2  2                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                           +                    +         |             
      Abscess                              |                                           2                              |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Dilatation                     |                                           3                    4         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      1                          3                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
      Bronchial, Infiltration Cellular,    |                                                                          |             
           Polymorphonuclear               |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Polymorphonuclear               |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                 3                        |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Polymorphonuclear                |                                                 1                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                      1                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +     +                    +                          +   |             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 6| 7| 7| 7| 6| 6| 4| 5| 7| 6| 6| 6| 6| 6| 0| 6| 7| 6| 6| 6| 0|             
                             DAY ON TEST   | 6| 8| 9| 1| 5| 1| 2| 2| 8| 3| 3| 2| 1| 4| 0| 7| 8| 9| 0| 7| 0| 9| 8| 1| 0|             
                                           | 4| 7| 6| 1| 2| 1| 9| 6| 9| 5| 6| 7| 1| 3| 4| 8| 7| 5| 4| 2| 7| 8| 8| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                2     3                    1                              |             
      Sinus, Ectasia                       |                3                                                     3   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |             3                 4                       4                 4|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 4  3  4  4     3  3  4  4           4  2  3  4  3  4        1  3  4  3   |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  I  +  +  M  +  M  M  +  M  +  M  M  M  +  +  +  +  M  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Acanthosis                           |                         2                          1                     |             
      Edema                                | 3                                                                        |             
      Hyperkeratosis                       |    1        1                                                            |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Necrotizing            |    4                    4                          3                     |             
      Back, Acanthosis                     |       2                                            1        2     2      |             
      Back, Hyperkeratosis                 |       1                                            1              1      |             
      Scapula, Acanthosis                  | 2  2  3  1  2  2  3  2  3  2     2     2  2     1  2     2  2  2  3  3   |             
      Scapula, Hyperkeratosis              | 1  1  1                 1     1        1  1                              |             
      Scapula, Inflammation, Chronic Active|                   2                                                      |             
      Scapula, Inflammation, Necrotizing   |                   3  2  4  2                       1                 3   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |                1     1  1  1  1  1  1     1  1  1           1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                         1  1                                             |             
      Hemorrhage, Multifocal               |                                                                   1      |             
      Thrombosis                           |                                                          X               |             
      Interstitium, Inflammation, Chronic  |                            2                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 6| 7| 7| 7| 6| 6| 4| 5| 7| 6| 6| 6| 6| 6| 0| 6| 7| 6| 6| 6| 0|             
                             DAY ON TEST   | 6| 8| 9| 1| 5| 1| 2| 2| 8| 3| 3| 2| 1| 4| 0| 7| 8| 9| 0| 7| 0| 9| 8| 1| 0|             
                                           | 4| 7| 6| 1| 2| 1| 9| 6| 9| 5| 6| 7| 1| 3| 4| 8| 7| 5| 4| 2| 7| 8| 8| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                   3                                                      |             
      Inflammation, Subacute               |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Inflammation, Multifocal, Subacute   |                                                 3                        |             
      Inflammation, Necrotizing            |                                                                          |             
      Renal Tubule, Bacterium              |                                                                          |             
      Renal Tubule, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 0| 6| 6| 0| 6| 5| 6| 7| 7| 7| 6| 7| 5| 7| 5| 6| 6| 5| 4| 4| 0| 2| 4|             
                             DAY ON TEST   | 1| 4| 0| 8| 2| 4| 2| 2| 2| 0| 2| 2| 2| 2| 9| 2| 7| 2| 8| 2| 5| 5| 3| 4| 5|             
                                           | 4| 3| 4| 4| 5| 2| 5| 0| 5| 8| 3| 9| 5| 9| 4| 9| 2| 5| 7| 3| 9| 8| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        M  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Amyloid Deposition                   |          3                                                               |             
      Basophilic Focus                     |                                  3           3                           |             
      Cyst                                 |          X  X                    X                                       |             
      Inclusion Body Intracytoplasmic      |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |             3     3     2                                                |             
      Necrosis, Coagulative, Focal         |                                                                          |             
      Necrosis, Coagulative, Multifocal    |    4              1                                   2                  |             
      Thrombosis                           |                         X                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Acinus, Atrophy                      |                                           1                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Inflammation, Multifocal, Subacute   |                   2     2                                                |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +        +  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                      +   |             
      Aorta, Bacterium                     |                                                                      X   |             
      Aorta, Inflammation, Chronic Active  |                                                                      3   |             
      Aorta, Thrombosis                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Myocardium, Mineralization,          |                                                                          |             
          Multifocal                       |                                                                   2      |             
      Valve, Bacterium                     |                                                       X                  |             
      Valve, Inflammation, Subacute        |                                                       2                  |             
      Valve, Thrombosis                    |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Capsule, Hyperplasia                 | 1  2  1  2  1     1     1  1  1  4  3  3  2  3  1  1  2  2           1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 0| 6| 6| 0| 6| 5| 6| 7| 7| 7| 6| 7| 5| 7| 5| 6| 6| 5| 4| 4| 0| 2| 4|             
                             DAY ON TEST   | 1| 4| 0| 8| 2| 4| 2| 2| 2| 0| 2| 2| 2| 2| 9| 2| 7| 2| 8| 2| 5| 5| 3| 4| 5|             
                                           | 4| 3| 4| 4| 5| 2| 5| 0| 5| 8| 3| 9| 5| 9| 4| 9| 2| 5| 7| 3| 9| 8| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Hyperplasia, Focal, Nodular          |                                                                          |             
      Hyperplasia, Nodular                 |                               2  2  1  1                                 |             
      Necrosis, Liquifactive               |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Necrosis, Liquifactive               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +        +  M   |             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  M  M  +  M  +  +  +  +  +        +  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M        +  M   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  M   |             
      Hyperplasia, Nodular                 |                                                                          |             
      Follicle, Hyperplasia, Nodular       |                                  1           1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Inflammation, Subacute               |             1     3     2                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                                      +        +                     |             
      Abscess                              |                                           4                              |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Dilatation                     |    4                                               2                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Inflammation, Chronic Active         |    2              3     3                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Seminiferous Tubule, Atrophy         |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +        M  +   |             
      Bronchial, Infiltration Cellular,    |                                                                          |             
           Polymorphonuclear               |                         3                                                |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Polymorphonuclear               |                   3     3                                                |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  M  +  +        M  +   |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                   2     2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +  +  +  +  +  +  +              +        +                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 0| 6| 6| 0| 6| 5| 6| 7| 7| 7| 6| 7| 5| 7| 5| 6| 6| 5| 4| 4| 0| 2| 4|             
                             DAY ON TEST   | 1| 4| 0| 8| 2| 4| 2| 2| 2| 0| 2| 2| 2| 2| 9| 2| 7| 2| 8| 2| 5| 5| 3| 4| 5|             
                                           | 4| 3| 4| 4| 5| 2| 5| 0| 5| 8| 3| 9| 5| 9| 4| 9| 2| 5| 7| 3| 9| 8| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |          3  3     3  2  2  3              3                              |             
      Sinus, Ectasia                       |          3                 3                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Depletion Lymphoid                   |                2                                                  4      |             
      Fibrosis                             |                                                          1               |             
      Hematopoietic Cell Proliferation     | 3        4  3     4  3  3  4     2  3     3     3     4                  |             
      Necrosis, Coagulative                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  M  +  M  +  +  +  M  +  +  +  M  +  M  M  +  M        M  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  M  M  M  M  M  M  M  +  M  M  +  M  M  M  +  M        +  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Abscess                              |                                     3                                    |             
      Acanthosis                           |          2                             1              3                  |             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |                         3                                                |             
      Inflammation, Necrotizing            |          1        4                                   4                  |             
      Back, Acanthosis                     | 2                 2                                                      |             
      Back, Hyperkeratosis                 |                            1                                             |             
      Scapula, Acanthosis                  | 2  1     2  2     2  2     2  2  1  3  3  2  2  2     3  2               |             
      Scapula, Hyperkeratosis              |          1  1                 1  1        1     1                        |             
      Scapula, Inflammation, Chronic Active|                                                                          |             
      Scapula, Inflammation, Necrotizing   | 1                          3     3  3  4              4                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Mineralization, Multifocal           | 1  1     1                 1  1     1  1     1  1  1  1  1               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Hemorrhage, Focal                    |                                                                          |             
      Hemorrhage, Multifocal               |                                           1                              |             
      Thrombosis                           |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  M   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 0| 6| 6| 0| 6| 5| 6| 7| 7| 7| 6| 7| 5| 7| 5| 6| 6| 5| 4| 4| 0| 2| 4|             
                             DAY ON TEST   | 1| 4| 0| 8| 2| 4| 2| 2| 2| 0| 2| 2| 2| 2| 9| 2| 7| 2| 8| 2| 5| 5| 3| 4| 5|             
                                           | 4| 3| 4| 4| 5| 2| 5| 0| 5| 8| 3| 9| 5| 9| 4| 9| 2| 5| 7| 3| 9| 8| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +        +  +   |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Subacute               |             2     2     1                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Infarct                              |          3                                                               |             
      Inflammation, Multifocal, Subacute   |                   3                                                      |             
      Inflammation, Necrotizing            |    3                                                                     |             
      Renal Tubule, Bacterium              |    X                                                                     |             
      Renal Tubule, Cyst                   |                                        X                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Ectasia                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 0| 4| 2| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 1| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 4| 9| 8| 8| 9| 8| 9| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +     +                                                               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +                                                               |  49        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M     +                                                               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     M                                                               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +                                                               |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +                                                               |  50        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                                          |      2  3.0|
      Cyst                                 |                                                                          |      4     |
      Inclusion Body Intracytoplasmic      | 2                                                                        |      2  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      6  2.5|
      Necrosis, Coagulative, Focal         |                                                                          |      1  2.0|
      Necrosis, Coagulative, Multifocal    |                                                                          |      5  2.6|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +                                                               |  50        |
      Acinus, Atrophy                      |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +                                                               |  50        |
      Inflammation, Multifocal, Subacute   |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +                                                               |  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Bacterium                     |                                                                          |      1     |
      Aorta, Inflammation, Chronic Active  |                                                                          |      1  3.0|
      Aorta, Thrombosis                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +                                                               |  50        |
      Myocardium, Mineralization,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Valve, Bacterium                     |          X                                                               |      2     |
      Valve, Inflammation, Subacute        |          4                                                               |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 0| 4| 2| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 1| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 4| 9| 8| 8| 9| 8| 9| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Valve, Thrombosis                    |          X                                                               |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +                                                               |  49        |
      Capsule, Hyperplasia                 | 2        1                                                               |     38  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +                                                               |  49        |
      Hyperplasia, Focal, Nodular          |                                                                          |      1  2.0|
      Hyperplasia, Nodular                 |                                                                          |      5  1.4|
      Necrosis, Liquifactive               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +                                                               |  48        |
      Necrosis, Liquifactive               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +                                                               |  47        |
      Hyperplasia                          |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M     +                                                               |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +                                                               |  42        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +                                                               |  49        |
      Hyperplasia, Nodular                 |                                                                          |      1  1.0|
      Follicle, Hyperplasia, Nodular       |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +                                                               |  50        |
      Inflammation, Subacute               |                                                                          |      6  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |   6        |
      Abscess                              |                                                                          |      2  3.0|
      Inflammation, Chronic                | 3                                                                        |      1  3.0|
      Duct, Dilatation                     | 3                                                                        |      5  3.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +                                                               |  50        |
      Inflammation, Chronic Active         |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +                                                               |  50        |
      Seminiferous Tubule, Atrophy         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +                                                               |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +                                                               |  45        |
      Bronchial, Infiltration Cellular,    |                                                                          |            |
           Polymorphonuclear               |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 0| 4| 2| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 1| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 4| 9| 8| 8| 9| 8| 9| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Polymorphonuclear               |                                                                          |      2  3.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +                                                               |  43        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |  13        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |     10  2.5|
      Sinus, Ectasia                       |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +                                                               |  50        |
      Depletion Lymphoid                   | 4  4                                                                     |      8  3.6|
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |          1                                                               |     31  3.2|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M     +                                                               |  27        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M     M                                                               |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +                                                               |  50        |
      Abscess                              |                                                                          |      1  3.0|
      Acanthosis                           |    1                                                                     |      6  1.7|
      Edema                                |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      2  1.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Necrotizing            |                                                                          |      6  3.3|
      Back, Acanthosis                     |                                                                          |      6  1.8|
      Back, Hyperkeratosis                 |                                                                          |      4  1.0|
      Scapula, Acanthosis                  | 1  1                                                                     |     38  2.1|
      Scapula, Hyperkeratosis              | 1                                                                        |     14  1.0|
      Scapula, Inflammation, Chronic Active|                                                                          |      1  2.0|
      Scapula, Inflammation, Necrotizing   |                                                                          |     12  2.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +                                                               |  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 0| 4| 2| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 1| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 4| 9| 8| 8| 9| 8| 9| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +                                                               |  50        |
      Mineralization, Multifocal           |                                                                          |     25  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +                                                               |  50        |
      Hemorrhage, Focal                    |                                                                          |      2  1.0|
      Hemorrhage, Multifocal               |                                                                          |      2  1.0|
      Thrombosis                           |                                                                          |      1     |
      Interstitium, Inflammation, Chronic  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +                                                               |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +     +                                                               |  48        |
      Hyperplasia, Nodular                 |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +                                                               |  50        |
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      2  3.0|
      Inflammation, Necrotizing            |                                                                          |      1  3.0|
      Renal Tubule, Bacterium              |                                                                          |      1     |
      Renal Tubule, Cyst                   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +                                                               |  49        |
      Ectasia                              |          3                                                               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 4| 4| 0| 4| 5| 4| 5| 4| 4| 5| 3| 5| 5| 4| 4| 5| 5| 5| 4| 5|             
                             DAY ON TEST   | 1| 7| 1| 7| 7| 5| 8| 2| 6| 7| 9| 7| 1| 5| 0| 7| 2| 4| 2| 9| 5| 5| 1| 7| 3|             
                                           | 6| 9| 5| 9| 7| 0| 6| 9| 6| 2| 3| 7| 9| 1| 6| 6| 2| 4| 9| 8| 8| 0| 0| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                   4                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |             2                    1                          1            |             
      Inflammation, Diffuse, Subacute      |                                                                          |             
      Necrosis, Coagulative, Focal         |                                                                          |             
      Necrosis, Coagulative, Multifocal    |       3                             1     2                 1            |             
      Thrombosis                           |                                                                          |             
      Sinusoid, Centrilobular, Dilatation  |                                     3                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          1                                                  1            |             
      Duct, Ectasia                        |          2                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Multifocal, Necrotizing|                                                                2         |             
      Inflammation, Multifocal, Subacute   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                    3                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
      Inflammation, Acute                  |          3  1                             2                              |             
      Inflammation, Necrotizing            |                      1                                                   |             
      Ulcer                                |                                                 3                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                                                      |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Chronic            |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 4| 4| 0| 4| 5| 4| 5| 4| 4| 5| 3| 5| 5| 4| 4| 5| 5| 5| 4| 5|             
                             DAY ON TEST   | 1| 7| 1| 7| 7| 5| 8| 2| 6| 7| 9| 7| 1| 5| 0| 7| 2| 4| 2| 9| 5| 5| 1| 7| 3|             
                                           | 6| 9| 5| 9| 7| 0| 6| 9| 6| 2| 3| 7| 9| 1| 6| 6| 2| 4| 9| 8| 8| 0| 0| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +                                                         |             
      Aorta, Bacterium                     |                X                                                         |             
      Aorta, Inflammation, Chronic Active  |                2                                                         |             
      Aorta, Thrombosis                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                   3      |             
      Dilatation                           |                                     3                                    |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                                                          |             
      Myocardium, Inflammation, Focal,     |                                                                          |             
           Subacute                        |                                                                          |             
      Valve, Bacterium                     |                                                                X         |             
      Valve, Inflammation, Subacute        |                                                                2         |             
      Valve, Thrombosis                    |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 1  2  1     1  2  2  1  2  2  2        1  2  1  1  2     1  1  2  2  1  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                                           1                       1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  M  M  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |          2  2     2              3                    4     4  1         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                        +                                 |             
      Duct, Dilatation                     |                                        2                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          1                                                  2            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                   +                                                      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Femoral, Necrosis, Caseous           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 4| 4| 0| 4| 5| 4| 5| 4| 4| 5| 3| 5| 5| 4| 4| 5| 5| 5| 4| 5|             
                             DAY ON TEST   | 1| 7| 1| 7| 7| 5| 8| 2| 6| 7| 9| 7| 1| 5| 0| 7| 2| 4| 2| 9| 5| 5| 1| 7| 3|             
                                           | 6| 9| 5| 9| 7| 0| 6| 9| 6| 2| 3| 7| 9| 1| 6| 6| 2| 4| 9| 8| 8| 0| 0| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Deep Cervical, Infiltration Cellular,|                                                                          |             
           Polymorphonuclear               |                                                             2            |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Polymorphonuclear               |                                                             2            |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |             2                    1              2              2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +                    +                                +  +         |             
      Hematopoietic Cell Proliferation     |                                                                2         |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |       3                    1                                3            |             
      Sinus, Ectasia                       |       3                    2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 4  2  4  3  2     4     2  3  4  4  4  4  4  4  4  4        4  3  3     4|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  M  +  +  +  +  +  M  +  M  M  +  +  +  +  +  M  M  +  M  M  +|             
      Necrosis                             |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                         1                                                |             
      Cyst Epithelial Inclusion            |       X                                                                  |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Back, Acanthosis                     |                                                    3                     |             
      Back, Hyperkeratosis                 |                                  1                    1                  |             
      Back, Inflammation, Necrotizing      |                                                    4                     |             
      Lymphatic, Dilatation                |                                                                          |             
      Scapula, Acanthosis                  | 2  3           2           2  1        2     1  1     2  2  3  2     2  2|             
      Scapula, Hyperkeratosis              | 2  2                    1     1        2              1  2  2  1     2   |             
      Scapula, Inflammation, Necrotizing   |    2                       2           1  2  3                          1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Femur, Thrombosis            |                                                                          |             
      Tibia, Inflammation, Acute           |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 4| 4| 0| 4| 5| 4| 5| 4| 4| 5| 3| 5| 5| 4| 4| 5| 5| 5| 4| 5|             
                             DAY ON TEST   | 1| 7| 1| 7| 7| 5| 8| 2| 6| 7| 9| 7| 1| 5| 0| 7| 2| 4| 2| 9| 5| 5| 1| 7| 3|             
                                           | 6| 9| 5| 9| 7| 0| 6| 9| 6| 2| 3| 7| 9| 1| 6| 6| 2| 4| 9| 8| 8| 0| 0| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Autolysis                            |                                                                          |             
      Hemorrhage, Multifocal               |                                                                1         |             
      Mineralization, Multifocal           |       1                 1     1  1     1           1  1           1  1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                1     1   |             
      Hemorrhage, Multifocal               |                               2                                          |             
      Thrombosis                           |                                     X                                    |             
      Alveolar Epithelium, Hyperplasia     |       3                                                                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                   2      |             
      Interstitium, Inflammation, Chronic  |                      1                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  M  +     +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Subacute               |                                  1                          2            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Multifocal, Subacute   |             2                                                            |             
      Inflammation, Necrotizing            |                                                                1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 4| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 4| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 1| 9| 6| 0| 1| 9| 8| 0| 7| 2| 2| 1| 3| 7| 7| 6| 0| 6| 5| 5| 5| 5| 5| 4|             
                                           | 5| 4| 9| 5| 5| 5| 3| 0| 8| 2| 0| 3| 6| 4| 9| 6| 5| 9| 5| 9| 9| 8| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |             2  2     3                             4                     |             
      Inflammation, Diffuse, Subacute      |                         3                                                |             
      Necrosis, Coagulative, Focal         |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                         1                          1                     |             
      Thrombosis                           |                                        X                                 |             
      Sinusoid, Centrilobular, Dilatation  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Inflammation, Subacute               |                3                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Inflammation, Multifocal, Necrotizing|                                                                          |             
      Inflammation, Multifocal, Subacute   |                2                                                         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Acanthosis                           |                                                       2                  |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Hyperplasia                          |                   1                                                      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Ulcer                                |          3        2                                                      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Chronic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 4| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 4| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 1| 9| 6| 0| 1| 9| 8| 0| 7| 2| 2| 1| 3| 7| 7| 6| 0| 6| 5| 5| 5| 5| 5| 4|             
                                           | 5| 4| 9| 5| 5| 5| 3| 0| 8| 2| 0| 3| 6| 4| 9| 6| 5| 9| 5| 9| 9| 8| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Bacterium                     |                                                                          |             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
      Aorta, Thrombosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Cardiomyopathy                       |                                                                          |             
      Dilatation                           |                                                                          |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |          1              1  1                                             |             
      Myocardium, Inflammation, Focal,     |                                                                          |             
           Subacute                        |                                                    1                     |             
      Valve, Bacterium                     |                                                                          |             
      Valve, Inflammation, Subacute        |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Capsule, Hyperplasia                 | 1  1  2  1  3  1  1  1  2  1  1  2  2  1  2  2  2     1                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Hyperplasia, Nodular                 |                1                 1        1                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Hyperplasia                          |          1                             1     1        1                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +                 M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  I  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +                 M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M|             
      Inflammation, Subacute               |             3  4     2                          2  3                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Inflammation, Chronic Active         |             3  2        2                          3                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Femoral, Necrosis, Caseous           |                4                                                         |             
      Myeloid Cell, Hyperplasia            |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 4| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 4| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 1| 9| 6| 0| 1| 9| 8| 0| 7| 2| 2| 1| 3| 7| 7| 6| 0| 6| 5| 5| 5| 5| 5| 4|             
                                           | 5| 4| 9| 5| 5| 5| 3| 0| 8| 2| 0| 3| 6| 4| 9| 6| 5| 9| 5| 9| 9| 8| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M|             
      Deep Cervical, Infiltration Cellular,|                                                                          |             
           Polymorphonuclear               |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Polymorphonuclear               |                2                                                         |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +                 M|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +           +        +  +     +                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                   2           3           2                              |             
      Sinus, Ectasia                       |                   2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Depletion Lymphoid                   |       3              2                                                   |             
      Hematopoietic Cell Proliferation     |    3     3  3  4  4     4  4  4  3  4  4  4  3  4  4  4                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  M  +  M  M  +  M  M  +  +  M  M  M  +  +  M  +                 M|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M                 +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Acanthosis                           |                            1                                             |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Acute                  |                            2                                             |             
      Inflammation, Chronic                |                                     1                                    |             
      Inflammation, Necrotizing            |                                                                          |             
      Back, Acanthosis                     |                         1                                                |             
      Back, Hyperkeratosis                 |                         1                                               1|             
      Back, Inflammation, Necrotizing      |                                                                          |             
      Lymphatic, Dilatation                |    4                                                                     |             
      Scapula, Acanthosis                  | 1  1  2  2  2  2  2  1  2  2  1  3     3  3  3  3  2  2                  |             
      Scapula, Hyperkeratosis              | 1  1  2                          1     2  2     1  1  1                  |             
      Scapula, Inflammation, Necrotizing   |       2           2  4  2        3           2  1                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Artery, Femur, Thrombosis            |                X                                                         |             
      Tibia, Inflammation, Acute           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 4| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 4| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 1| 9| 6| 0| 1| 9| 8| 0| 7| 2| 2| 1| 3| 7| 7| 6| 0| 6| 5| 5| 5| 5| 5| 4|             
                                           | 5| 4| 9| 5| 5| 5| 3| 0| 8| 2| 0| 3| 6| 4| 9| 6| 5| 9| 5| 9| 9| 8| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Autolysis                            | 3                                                                        |             
      Hemorrhage, Multifocal               |                                                                          |             
      Mineralization, Multifocal           |    1     1     1     1  1        1  1     1     1  1  1                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Hemorrhage, Focal                    |                   1                                                      |             
      Hemorrhage, Multifocal               |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +                 M|             
      Inflammation, Chronic, Focal         |                               2                                          |             
      Inflammation, Subacute               |                3                    2           2                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Inflammation, Multifocal, Subacute   |                2                                   3                     |             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +                 +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5|                                            |            |
                                           | 9| 1| 8| 2| 8| 4| 4| 2| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +     +     +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +     +     +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +     +     +  +  +                                                   |  49        |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +     +  +  +                                                   |  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     +     +  +  +                                                   |  48        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +     +     +  +  +                                                   |  50        |
      Hematopoietic Cell Proliferation     |                      1                                                   |      1  1.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      7  2.1|
      Inflammation, Diffuse, Subacute      |                                                                          |      1  3.0|
      Necrosis, Coagulative, Focal         |    1                                                                     |      1  1.0|
      Necrosis, Coagulative, Multifocal    |                                                                          |      6  1.5|
      Thrombosis                           |                      X                                                   |      2     |
      Sinusoid, Centrilobular, Dilatation  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Inflammation, Subacute               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +     +  +  +                                                   |  49        |
      Acinus, Atrophy                      |                                                                          |      2  1.0|
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +     +     +  +  +                                                   |  50        |
      Inflammation, Multifocal, Necrotizing|                                                                          |      1  2.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +     +     +  +  +                                                   |  50        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +     +     +  +  +                                                   |  50        |
      Hyperplasia                          |                                                                          |      2  1.5|
      Inflammation, Acute                  |                                                                          |      3  2.0|
      Inflammation, Necrotizing            |                                                                          |      1  1.0|
      Ulcer                                |                1                                                         |      4  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  95                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5|                                            |            |
                                           | 9| 1| 8| 2| 8| 4| 4| 2| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Molar,            |                                                                          |            |
          Inflammation, Chronic            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Bacterium                     |                                                                          |      1     |
      Aorta, Inflammation, Chronic Active  |                                                                          |      1  2.0|
      Aorta, Thrombosis                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +     +     +  +  +                                                   |  50        |
      Cardiomyopathy                       |                                                                          |      1  3.0|
      Dilatation                           |                                                                          |      1  3.0|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                                                                          |      3  1.0|
      Myocardium, Inflammation, Focal,     |                                                                          |            |
           Subacute                        |                                                                          |      1  1.0|
      Valve, Bacterium                     |                                                                          |      1     |
      Valve, Inflammation, Subacute        |                                                                          |      1  2.0|
      Valve, Thrombosis                    |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +     +  +  +                                                   |  50        |
      Capsule, Hyperplasia                 |    1     2     2  1  1                                                   |     44  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +     +     +  +  +                                                   |  50        |
      Hyperplasia, Nodular                 |                                                                          |      5  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +     +     +  +  +                                                   |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +     +     +  +  +                                                   |  48        |
      Hyperplasia                          |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +     +     +  M  +                                                   |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +     +     +  +  +                                                   |  38        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +     +     +  +  +                                                   |  48        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +     +     +  +  +                                                   |  49        |
      Inflammation, Subacute               |          2                                                               |     13  2.6|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5|                                            |            |
                                           | 9| 1| 8| 2| 8| 4| 4| 2| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Duct, Dilatation                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +     +     +  +  +                                                   |  50        |
      Inflammation, Chronic Active         |                                                                          |      6  2.2|
                                            __________________________________________________________________________|____________|
   Testes                                  |    +     +     +  +  +                                                   |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +     +     +  +  +                                                   |  49        |
      Femoral, Necrosis, Caseous           |                                                                          |      1  4.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     M     +  +  +                                                   |  46        |
      Deep Cervical, Infiltration Cellular,|                                                                          |            |
           Polymorphonuclear               |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Polymorphonuclear               |                                                                          |      2  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +     M     +  +  +                                                   |  44        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                      1                                                   |      5  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   9        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      6  2.3|
      Sinus, Ectasia                       |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +     +  +  +                                                   |  50        |
      Depletion Lymphoid                   |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |    4     2           4                                                   |     39  3.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +     +     +  +  M                                                   |  27        |
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M     M     M  M  M                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +     +  +  +                                                   |  50        |
      Acanthosis                           |    2           1  1                                                      |      5  1.2|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Necrotizing            |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5|                                            |            |
                                           | 9| 1| 8| 2| 8| 4| 4| 2| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Back, Acanthosis                     |                                                                          |      2  2.0|
      Back, Hyperkeratosis                 |                                                                          |      4  1.0|
      Back, Inflammation, Necrotizing      |                                                                          |      1  4.0|
      Lymphatic, Dilatation                |                                                                          |      1  4.0|
      Scapula, Acanthosis                  |    2     2           2                                                   |     35  2.0|
      Scapula, Hyperkeratosis              |    1                 1                                                   |     21  1.4|
      Scapula, Inflammation, Necrotizing   |    1     3                                                               |     15  2.1|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +     +  +  +                                                   |  50        |
      Artery, Femur, Thrombosis            |                                                                          |      1     |
      Tibia, Inflammation, Acute           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +     +     +  +  +                                                   |  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Hemorrhage, Multifocal               |                                                                          |      1  1.0|
      Mineralization, Multifocal           |                      1                                                   |     22  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +     +  +  +                                                   |  50        |
      Hemorrhage, Focal                    |                                                                          |      3  1.0|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +     +     +  +  +                                                   |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +     +     +  +  +                                                   |  42        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +     +  +  +                                                   |  50        |
      Inflammation, Multifocal, Subacute   |                                                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05044-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:51:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5|                                            |            |
                                           | 9| 1| 8| 2| 8| 4| 4| 2| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Necrotizing            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +     +  +  +                                                   |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
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