National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1293

TDMS Study 05044-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE


NTP Experiment-Test: 05044-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/06/94
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:45




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  106-87-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05044-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                               8           13           21                                                  
    Moribund                                          15           14           14                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           23           15                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (50)         (50)                                                
      Neoplastic Nodule                                                          1 (2%)                                             
   Mesentery                                          (4)          (2)                                                              
      Lipoma                                                        1 (50%)                                                         
   Pancreas                                           (48)         (47)         (48)                                                
   Pharynx                                                         (1)          (1)                                                 
      Palate, Squamous Cell Carcinoma                               1 (100%)                                                        
   Stomach, Forestomach                               (50)         (48)         (50)                                                
   Stomach, Glandular                                 (50)         (48)         (50)                                                
   Tongue                                             (1)          (1)          (1)                                                 
      Squamous Cell Papilloma                          1 (100%)     1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (48)         (50)                                                
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Adrenal Gland, Medulla                             (50)         (48)         (50)                                                
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          2 (4%)       2 (4%)       1 (2%)                                             
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (48)         (48)         (48)                                                
      Adenoma                                                       1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (47)         (43)         (48)                                                
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (47)         (49)         (48)                                                
                                                             Page   2                                                               
NTP Experiment-Test: 05044-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenoma                          19 (40%)     14 (29%)     17 (35%)                                            
      Pars Distalis, Carcinoma                        14 (30%)     15 (31%)     11 (23%)                                            
   Thyroid Gland                                      (46)         (48)         (49)                                                
      Bilateral, C-Cell, Adenoma                       1 (2%)       2 (4%)                                                          
      C-Cell, Adenoma                                  4 (9%)      12 (25%)      9 (18%)                                            
      C-Cell, Adenoma, Multiple                        1 (2%)                                                                       
      C-Cell, Carcinoma                                             3 (6%)       1 (2%)                                             
      Follicular Cell, Adenoma                         2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (50)         (49)                                                
      Adenoma                                          2 (4%)       7 (14%)      3 (6%)                                             
      Carcinoma                                        1 (2%)                                                                       
      Sarcoma                                                                    1 (2%)                                             
   Ovary                                              (50)         (49)         (50)                                                
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Luteoma                                                       1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)                                                
      Carcinoma                                                     1 (2%)                                                          
      Polyp Stromal                                    3 (6%)       7 (14%)      6 (12%)                                            
      Polyp Stromal, Multiple                                       1 (2%)                                                          
      Sarcoma Stromal                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (3)                       (1)                                                 
   Bone Marrow                                        (50)         (49)         (49)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
      Axillary, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Skin                                                       1 (2%)                                             
   Lymph Node, Mandibular                             (50)         (50)         (50)                                                
   Lymph Node, Mesenteric                             (3)                       (2)                                                 
      Hemangiosarcoma                                                            1 (50%)                                            
   Spleen                                             (50)         (50)         (49)                                                
   Thymus                                             (44)         (43)         (41)                                                
      Thymoma Benign                                                             1 (2%)                                             
      Thymoma Malignant                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05044-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (50)                                                
      Adenocarcinoma                                   2 (4%)       3 (6%)       1 (2%)                                             
      Fibroadenoma                                    14 (28%)     11 (22%)      8 (16%)                                            
      Fibroadenoma, Multiple                           6 (12%)                                                                      
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Adenoma                               1 (2%)       1 (2%)                                                          
      Back, Squamous Cell Carcinoma                                              1 (2%)                                             
      Back, Sebaceous Gland, Adenoma                   1 (2%)                                                                       
      Scapula, Basal Cell Carcinoma                                 3 (6%)       4 (8%)                                             
      Scapula, Squamous Cell Carcinoma                              8 (16%)     12 (24%)                                            
      Scapula, Squamous Cell Carcinoma, Multiple                    8 (16%)     22 (44%)                                            
      Scapula, Squamous Cell Papilloma                                           1 (2%)                                             
      Sebaceous Gland, Scapula, Adenoma                             1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     2 (4%)                                                                       
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
      Abdominal, Rhabdomyosarcoma                      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Pituitary Gland           3 (6%)       3 (6%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Squamous Cell Carcinoma, Metastatic, Skin                                  3 (6%)                                             
   Nose                                               (49)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05044-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Nephroblastoma Malignant                                      1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (48)                                                
      Transitional Epithelium, Papilloma                            2 (4%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            12 (24%)     17 (34%)     13 (26%)                                            
      Lymphoma Malignant Histiocytic                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05044-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          47          44                                                   
     Total Primary Neoplasms                           95         128         119                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 39          40          32                                                   
     Total Benign Neoplasms                            62          67          52                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          38          39                                                   
     Total Malignant Neoplasms                         33          61          67                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3           6                                                   
     Total Metastatic Neoplasm                          3           3           7                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05044-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          31           37           29                                                  
    Dead                                              12            5           16                                                  
    Drowned                                                                      1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 7            8            4                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (45)         (48)         (40)                                                
   Intestine Large, Colon                             (48)         (49)         (40)                                                
      Carcinoma                                                     1 (2%)                                                          
   Intestine Large, Rectum                            (48)         (48)         (44)                                                
      Carcinoma                                                     1 (2%)                                                          
   Intestine Small, Duodenum                          (48)         (50)         (45)                                                
      Adenocarcinoma                                                             1 (2%)                                             
   Intestine Small, Ileum                             (44)         (49)         (37)                                                
   Intestine Small, Jejunum                           (46)         (49)         (42)                                                
   Liver                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (2%)                                                          
   Mesentery                                          (7)          (6)          (6)                                                 
      Carcinoma, Metastatic, Skin                                                1 (17%)                                            
      Carcinoma, Metastatic, Intestine Large                        1 (17%)                                                         
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (17%)                                                         
   Pancreas                                           (50)         (50)         (45)                                                
      Carcinoma, Metastatic, Intestine Large                        1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (2%)                                                          
   Pharynx                                            (2)          (2)                                                              
      Palate, Squamous Cell Papilloma                  1 (50%)                                                                      
   Salivary Glands                                    (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Skin                                                1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (47)                                                
   Stomach, Glandular                                 (50)         (50)         (48)                                                
      Leiomyosarcoma                                   1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (2%)                                                          
   Tongue                                                          (1)          (1)                                                 
      Squamous Cell Papilloma                                       1 (100%)                                                        
                                                             Page   7                                                               
NTP Experiment-Test: 05044-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Skin                                                1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Medulla, Squamous Cell Carcinoma, Metastatic,                                                                                 
           Skin                                                     1 (2%)                                                          
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Pheochromocytoma Malignant                                                 2 (4%)                                             
      Pheochromocytoma Benign                          6 (12%)     11 (22%)                                                         
      Bilateral, Pheochromocytoma Benign               2 (4%)       4 (8%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (46)                                                
      Adenoma                                          1 (2%)       2 (4%)       3 (7%)                                             
      Carcinoma                                                     2 (4%)                                                          
   Parathyroid Gland                                  (49)         (45)         (45)                                                
      Adenoma                                                       2 (4%)       1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (48)                                                
      Pars Distalis, Adenoma                          24 (48%)     26 (52%)     26 (54%)                                            
      Pars Distalis, Adenoma, Multiple                                           1 (2%)                                             
      Pars Distalis, Carcinoma                         2 (4%)       1 (2%)                                                          
   Thyroid Gland                                      (48)         (50)         (43)                                                
      C-Cell, Adenoma                                  7 (15%)      5 (10%)      2 (5%)                                             
      C-Cell, Adenoma, Multiple                                     1 (2%)                                                          
      C-Cell, Carcinoma                                2 (4%)                                                                       
      Follicular Cell, Adenoma                         1 (2%)       3 (6%)       3 (7%)                                             
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (48)                                                
   Preputial Gland                                    (49)         (49)         (50)                                                
      Adenoma                                                       3 (6%)       1 (2%)                                             
      Squamous Cell Papilloma                                       2 (4%)                                                          
   Prostate                                           (49)         (50)         (50)                                                
   Testes                                             (50)         (50)         (50)                                                
                                                             Page   8                                                               
NTP Experiment-Test: 05044-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Bilateral, Interstitial Cell, Adenoma           34 (68%)     35 (70%)     25 (50%)                                            
      Interstitial Cell, Adenoma                      10 (20%)      5 (10%)     14 (28%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (7)          (1)          (2)                                                 
   Bone Marrow                                        (50)         (50)         (49)                                                
      Femoral, Squamous Cell Carcinoma, Metastatic,                                                                                 
           Skin                                                     1 (2%)                                                          
   Lymph Node                                         (50)         (50)         (50)                                                
      Mediastinal, Carcinoma, Metastatic, Skin                                   1 (2%)                                             
   Lymph Node, Mandibular                             (50)         (49)         (50)                                                
   Lymph Node, Mesenteric                             (7)          (10)         (3)                                                 
      Carcinoma, Metastatic, Intestine Large                        1 (10%)                                                         
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Skin                                          1 (10%)                                                         
   Spleen                                             (50)         (50)         (49)                                                
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (2%)                                                          
   Thymus                                             (41)         (40)         (42)                                                
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (48)         (42)                                                
      Adenocarcinoma                                   1 (2%)       2 (4%)                                                          
      Fibroadenoma                                     1 (2%)       1 (2%)       1 (2%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Adenoma                               1 (2%)                                                                       
      Basal Cell Carcinoma                             1 (2%)       1 (2%)                                                          
      Keratoacanthoma                                                            2 (4%)                                             
      Trichoepithelioma                                                          1 (2%)                                             
      Back, Keratoacanthoma                                         1 (2%)                                                          
      Back, Squamous Cell Carcinoma                                 2 (4%)       1 (2%)                                             
      Back, Subcutaneous Tissue, Fibroma                            1 (2%)                                                          
      Back, Sebaceous Gland, Adenoma                                1 (2%)                                                          
      Scapula, Basal Cell Adenoma                                                4 (8%)                                             
      Scapula, Basal Cell Carcinoma                                 1 (2%)       2 (4%)                                             
      Scapula, Basal Cell Carcinoma, Multiple                                    1 (2%)                                             
      Scapula, Basal Cell Carcinoma, Metastatic,                                                                                    
           Skin                                                                  1 (2%)                                             
      Scapula, Carcinoma                                                         1 (2%)                                             
      Scapula, Keratoacanthoma                                      1 (2%)       1 (2%)                                             
      Scapula, Squamous Cell Carcinoma                             10 (20%)     12 (24%)                                            
      Scapula, Squamous Cell Carcinoma, Multiple                   22 (44%)     24 (48%)                                            
      Scapula, Squamous Cell Carcinoma, Metastatic,                                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05044-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
           Skin                                                     1 (2%)                                                          
      Scapula, Squamous Cell Papilloma                              3 (6%)       6 (12%)                                            
      Sebaceous Gland, Scapula, Adenoma                             1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
      Subcutaneous Tissue, Liposarcoma                              1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Scapula, Fibrosarcoma                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)          (1)                                                 
      Diaphragm, Carcinoma, Metastatic, Skin                                     1 (100%)                                           
      Diaphragm, Intercostal, Squamous Cell                                                                                         
          Carcinoma, Metastatic, Skin                               1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)                                                
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Carcinoma, Metastatic                                                      1 (2%)                                             
      Carcinoma, Metastatic, Skin                                                1 (2%)                                             
      Chordoma                                         1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                          1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Skin                     4 (8%)       1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Uncertain Primary Site                                    1 (2%)                                                          
   Nose                                               (50)         (50)         (49)                                                
   Trachea                                            (50)         (49)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (7)          (3)          (6)                                                 
   Zymbal's Gland                                                               (2)                                                 
      Adenoma                                                                    1 (50%)                                            
      Carcinoma                                                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                             Page  10                                                               
NTP Experiment-Test: 05044-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Carcinoma, Metastatic, Skin                                                1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (2%)                                                          
      Renal Tubule, Adenoma                                                      1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            16 (32%)     15 (30%)     15 (30%)                                            
      Mesothelioma Malignant                           1 (2%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05044-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          49          49                                                   
     Total Primary Neoplasms                          117         173         156                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50          45          46                                                   
     Total Benign Neoplasms                            90         111          94                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          39          41                                                   
     Total Malignant Neoplasms                         27          62          62                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           7           5                                                   
     Total Metastatic Neoplasm                          1          23          11                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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