TDMS Study 05049-02 Pathology Tables
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
Facility: Southern Research Institute
Chemical CAS #: 62-73-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|
| 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Diverticulum | |
Necrosis | 2 |
__________________________________________________________________________|
Gallbladder | + + + + + A + + + M A + + + + + + M M + M + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + M + + + + + + + + + + + + + +|
Cecum, Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +|
Duodenum, Hyperplasia, Re Cell | 3 |
Jejunum, Peyer's Patch, Hyperplasia, | |
Mononuclear Cell | 3 |
Mucosa, Ileum, Dysplasia | 3 |
Submucosa, Ileum, Infiltration | |
Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 4 3 |
Inflammation, Chronic | 2 3 2 2 1 2 1 2 2 1 3 |
Inflammation, Chronic Active | 2 2|
Bile Duct, Cyst | |
Hepatocyte, Cytoplasmic Alteration | |
Hepatocyte, Karyomegaly | |
Hepatocyte, Necrosis | 1 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
Kupffer Cell, Hyperplasia | 3 |
Kupffer Cell, Pigmentation | 2 3 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 3 |
Artery, Hypertrophy | 3 |
Artery, Inflammation, Chronic | 3 4 |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + A + I + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cytoplasmic Alteration | 2 |
Hyperplasia, Focal | 2 |
Infarct | 2 |
Inflammation, Chronic | 2 2 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 3 |
__________________________________________________________________________|
Stomach | + + + + + A + + + + + + + + + + + + + + + + + + +|
Forestomach, Cyst | X |
Forestomach, Diverticulum | X |
Forestomach, Erosion | 3 |
Forestomach, Hyperplasia, Focal | 1 2 2 |
Forestomach, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|
| 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Forestomach, Inflammation, Chronic | |
Glandular, Edema | |
Glandular, Erosion | |
Glandular, Inflammation, Chronic | 2 |
Glandular, Inflammation, Suppurative | 3 |
Glandular, Mineralization | 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic, Multiple | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | 3 |
Coronary Artery, Media, Hypertrophy | 4 |
Myocardium, Angiectasis | 2 |
Myocardium, Fibrosis | 1 2 |
Myocardium, Inflammation, Chronic | 2 2 |
Myocardium, Inflammation, Suppurative| 4 |
Pericardium, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 |
Cortex, Cyst | X |
Cortex, Degeneration, Fatty | 3 |
Cortex, Developmental Malformation | X |
Cortex, Hyperplasia, Focal | |
Medulla, Vacuolization Cytoplasmic | |
Spindle Cell, Hyperplasia | 3 2 3 2 3 2 2 2 3 3 2 2 2 3 3 3 3 3 3 3 3 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + A + + + + + + + + M + + + + + + + + + +|
Cyst | X X |
Ectopic Thymus | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + M + + + + + + M + + + + + + +|
Angiectasis | 3 |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 3 2 2 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 2 |
Inflammation, Suppurative | |
Follicle, Dilatation | 4 2 3 |
Follicular Cell, Hyperplasia | 3 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|
| 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Foreign Body | 4 4 |
Inflammation, Suppurative | 4 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + A + + + + + + + + + + + + + + M + + + +|
Cyst | X X X X X X X X|
Hemorrhage | 2 4 |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 4 4 4 4 4 |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hydrometra | |
Hyperplasia, Cystic | 3 3 3 4 4 4 4 4 3 3 3 3 3 3 3 3 2 2 2 3 3 4|
Hyperplasia, Cystic, Multiple | 4 |
Hyperplasia, Glandular | 3 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 3 3 4 3 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | A + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 2 4 4 3 |
Hyperplasia, Reticulum Cell | 2 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + M + + + + + + M + +|
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Plasma Cell | 2 |
Inguinal, Hyperplasia, Lymphoid | 3 |
Lymphatic, Mandibular, Ectasia | 3 |
Mandibular, Hyperplasia, Lymphoid | 2 |
Mandibular, Hyperplasia, Plasma Cell | 3 3 3|
Mediastinal, Angiectasis | 3 |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hyperplasia, Histiocytic| |
Mesenteric, Angiectasis | 3 |
Mesenteric, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|
| 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Hematopoietic Cell | |
Proliferation | 4 |
Mesenteric, Hemorrhage | 4 2 2 2 |
Mesenteric, Hyperplasia, Histiocytic | |
Mesenteric, Hyperplasia, Lymphoid | 3 |
Mesenteric, Hyperplasia, Plasma Cell | 3 |
Mesenteric, Infiltration Cellular, | |
Polymorphonuclear | |
Mesenteric, Inflammation, | |
Granulomatous | |
Mesenteric, Lymphatic, Ectasia | 4 |
Renal, Hematopoietic Cell | |
Proliferation | |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | 2 3 3 |
Renal, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Spleen | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | 3 3 2 4 3 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 2 2 3 3 3 |
Hyperplasia, Lymphoid | 2 2 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + M + + + + + M|
Atrophy | |
Cyst | X X |
Hyperplasia, Lymphoid | 3 |
Necrosis, Diffuse | 3 |
Medulla, Hyperplasia, Mononuclear | |
Cell | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Cystic | 3 2 2 2 3 2 3|
Hyperplasia, Lobular | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic Active | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 2 2 2 3 3 |
Necrosis | 2 |
Cranium, Hyperostosis | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|
| 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + + + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Hemorrhage | |
Cerebellum, Infiltration Cellular, | |
Lymphocyte | 2 2 |
Cerebrum, Hemorrhage | |
Cerebrum, Infiltration Cellular, | |
Lymphocyte | 2 |
Thalamus, Hemorrhage | |
Thalamus, Infiltration Cellular, | |
Lymphocyte | 2 |
Thalamus, Mineralization | 2 1 2 2 2 2 1 2 3 3 2 2 2 2 3 3 2|
Vein, Adventitia, Infiltration | |
Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + M + + + +|
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Chronic | 3 2 3 3 3 2 2 2 3 2 3 2 2 2 2 2 2 2|
Inflammation, Suppurative | 3 2 |
Interstitium, Edema | |
Pleura, Inflammation, Suppurative | 2 3 3 |
__________________________________________________________________________|
Nose | + + + + + M + + + + M + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | 3 2 2 |
Inflammation, Chronic Active | 3 3 3 |
Inflammation, Suppurative | 4 2 1 3 3 3 2 3 4 3 2 2 3 1 4 3|
__________________________________________________________________________|
Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Glands, Inflammation, Suppurative | 3|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +|
Casts | 1 1 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|
| 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | |
Glomerulosclerosis | |
Infarct | |
Inflammation, Chronic | 3 2 3 2 2 2 2 2 2 2 3 2 2 4 3 2|
Inflammation, Suppurative | 4 |
Metaplasia, Osseous | 2 |
Artery, Inflammation, Chronic | 4 |
Artery, Media, Hypertrophy | 4 |
Renal Tubule, Atrophy | |
Renal Tubule, Degeneration | 3 |
Renal Tubule, Dilatation | |
Renal Tubule, Regeneration | 2 1 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + I + + + + + I|
Edema | 3 |
Inflammation, Chronic | 2 2 3 2 2 3 3 3 2 3 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7| |
DAY ON TEST | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3| |
| 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Diverticulum | X | 1 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | M + + + M A + M + M + + + + + M A + I + + M + M I| 33 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cecum, Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + M A + + + M + + + +| 46 |
Duodenum, Hyperplasia, Re Cell | | 1 3.0|
Jejunum, Peyer's Patch, Hyperplasia, | | |
Mononuclear Cell | | 1 3.0|
Mucosa, Ileum, Dysplasia | | 1 3.0|
Submucosa, Ileum, Infiltration | | |
Cellular, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 2 | 8 2.9|
Inflammation, Chronic | 2 2 2 1 | 15 1.9|
Inflammation, Chronic Active | | 2 2.0|
Bile Duct, Cyst | X | 1 |
Hepatocyte, Cytoplasmic Alteration | 2 | 1 2.0|
Hepatocyte, Karyomegaly | 2 | 1 2.0|
Hepatocyte, Necrosis | 3 3 3 | 5 2.4|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 | 4 2.5|
Kupffer Cell, Hyperplasia | 4 4 | 3 3.7|
Kupffer Cell, Pigmentation | 3 | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 13 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 4 3 3 | 5 3.0|
Artery, Hypertrophy | | 1 3.0|
Artery, Inflammation, Chronic | | 2 3.5|
Fat, Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + M + + + + + + + +| 47 |
Atrophy | 2 | 2 3.0|
Cytoplasmic Alteration | | 1 2.0|
Hyperplasia, Focal | | 1 2.0|
Infarct | | 1 2.0|
Inflammation, Chronic | 2 | 4 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + I + + + + + + +| 49 |
Inflammation, Chronic | | 5 2.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7| |
DAY ON TEST | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3| |
| 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Forestomach, Cyst | | 1 |
Forestomach, Diverticulum | | 1 |
Forestomach, Erosion | | 1 3.0|
Forestomach, Hyperplasia, Focal | 1 2 2 | 6 1.7|
Forestomach, Inflammation, Acute | | 1 2.0|
Forestomach, Inflammation, Chronic | 2 | 1 2.0|
Glandular, Edema | 3 | 1 3.0|
Glandular, Erosion | 3 | 1 3.0|
Glandular, Inflammation, Chronic | | 1 2.0|
Glandular, Inflammation, Suppurative | 3 2 | 3 2.7|
Glandular, Mineralization | 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation, Chronic, Multiple | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coronary Artery, Inflammation, | | |
Chronic | 2 | 2 2.5|
Coronary Artery, Media, Hypertrophy | | 1 4.0|
Myocardium, Angiectasis | | 1 2.0|
Myocardium, Fibrosis | 1 | 3 1.3|
Myocardium, Inflammation, Chronic | | 2 2.0|
Myocardium, Inflammation, Suppurative| 2 2 | 3 2.7|
Pericardium, Inflammation, | | |
Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 2 2.5|
Cortex, Cyst | | 1 |
Cortex, Degeneration, Fatty | 3 2 2 | 4 2.5|
Cortex, Developmental Malformation | | 1 |
Cortex, Hyperplasia, Focal | 3 | 1 3.0|
Medulla, Vacuolization Cytoplasmic | 2 | 1 2.0|
Spindle Cell, Hyperplasia | 3 2 3 3 2 3 2 3 3 3 2 2 2 2 3 3 2 2| 40 2.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A M + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + M + + + + + + +| 46 |
Cyst | X | 3 |
Ectopic Thymus | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7| |
DAY ON TEST | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3| |
| 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + M + + + + + + + + +| 45 |
Angiectasis | | 1 3.0|
Pars Distalis, Angiectasis | 1 1 | 2 1.0|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 1 2 3 2 1 1 1| 13 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | | 2 2.5|
Inflammation, Suppurative | 1 | 1 1.0|
Follicle, Dilatation | 2 3 3 | 6 2.8|
Follicular Cell, Hyperplasia | 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + + + + | 7 |
Foreign Body | 4 4 4 3 | 6 3.8|
Inflammation, Suppurative | 4 4 4 3 | 6 3.8|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + M + + + + + M + + + + + + + +| 46 |
Cyst | X X X X X X X X X X| 18 |
Hemorrhage | 3 | 3 3.0|
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | 4 4 | 7 4.0|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Hydrometra | 3 | 1 3.0|
Hyperplasia, Cystic | 3 4 4 2 3 3 3 3 3 2 3 2 2 3 3 2 3 4| 40 3.0|
Hyperplasia, Cystic, Multiple | | 1 4.0|
Hyperplasia, Glandular | | 1 3.0|
Inflammation, Chronic | 3 | 2 3.0|
Inflammation, Suppurative | 2 4 2 3 | 8 3.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 3 3 3 4 | 14 3.1|
Hyperplasia, Reticulum Cell | | 1 2.0|
Myelofibrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7| |
DAY ON TEST | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3| |
| 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Iliac, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Iliac, Hyperplasia, Lymphoid | 2 | 1 2.0|
Iliac, Hyperplasia, Plasma Cell | | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
Lymphatic, Mandibular, Ectasia | | 1 3.0|
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
Mandibular, Hyperplasia, Plasma Cell | | 3 3.0|
Mediastinal, Angiectasis | | 1 3.0|
Mediastinal, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Mediastinal, Hyperplasia, Histiocytic| 3 | 1 3.0|
Mesenteric, Angiectasis | | 1 3.0|
Mesenteric, Atrophy | | 1 3.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 3 3 | 3 3.3|
Mesenteric, Hemorrhage | 3 2 3 | 7 2.6|
Mesenteric, Hyperplasia, Histiocytic | 3 | 1 3.0|
Mesenteric, Hyperplasia, Lymphoid | 3 | 2 3.0|
Mesenteric, Hyperplasia, Plasma Cell | | 1 3.0|
Mesenteric, Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Mesenteric, Inflammation, | | |
Granulomatous | 2 | 1 2.0|
Mesenteric, Lymphatic, Ectasia | | 1 4.0|
Renal, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Renal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Renal, Hyperplasia, Plasma Cell | 3 | 4 2.8|
Renal, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | | |
Granulocytic | 4 4 3 | 8 3.3|
Hematopoietic Cell Proliferation | | |
Erythrocytic | 2 3 4 3 | 9 2.8|
Hyperplasia, Lymphoid | 3 | 4 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + I M M M + + + + M + +| 41 |
Atrophy | 3 4 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7| |
DAY ON TEST | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3| |
| 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | | 2 |
Hyperplasia, Lymphoid | | 1 3.0|
Necrosis, Diffuse | 3 | 2 3.0|
Medulla, Hyperplasia, Mononuclear | | |
Cell | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Hyperplasia, Cystic | 4 3 2 3 2 | 12 2.6|
Hyperplasia, Lobular | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 3 2 2 2 2 3 2 | 15 2.3|
Necrosis | | 1 2.0|
Cranium, Hyperostosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 4 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebellum, Hemorrhage | 3 | 1 3.0|
Cerebellum, Infiltration Cellular, | | |
Lymphocyte | | 2 2.0|
Cerebrum, Hemorrhage | 3 | 1 3.0|
Cerebrum, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Thalamus, Hemorrhage | 3 | 1 3.0|
Thalamus, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Thalamus, Mineralization | 2 3 2 3 3 2 2 | 24 2.2|
Vein, Adventitia, Infiltration | | |
Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | M M + + + M M I + + + + + + + M + + + + M M + + +| 41 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7| |
DAY ON TEST | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3| |
| 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Infiltration Cellular, Histiocyte | 3 | 2 3.0|
Inflammation, Chronic | 3 2 2 2 2 2| 24 2.3|
Inflammation, Suppurative | | 2 2.5|
Interstitium, Edema | 3 2 2 | 3 2.3|
Pleura, Inflammation, Suppurative | 4 4 3 3 3 | 8 3.1|
__________________________________________________________________________|____________|
Nose | M + + + + M + + + + + + + + M M + + + + M + + + +| 43 |
Foreign Body | 3 | 1 3.0|
Inflammation, Chronic | 3 | 4 2.5|
Inflammation, Chronic Active | | 3 3.0|
Inflammation, Suppurative | 2 2 2 2 3 3 4 4 3 2| 26 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 3 | 2 3.5|
Glands, Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Casts | 2 2 1 2 3 | 12 1.7|
Cyst | X | 1 |
Glomerulosclerosis | 2 | 1 2.0|
Infarct | 3 | 1 3.0|
Inflammation, Chronic | 3 2 2 2 3 2 2 1 3 2 2 2 1 2| 30 2.2|
Inflammation, Suppurative | | 1 4.0|
Metaplasia, Osseous | 2 | 2 2.0|
Artery, Inflammation, Chronic | | 1 4.0|
Artery, Media, Hypertrophy | | 1 4.0|
Renal Tubule, Atrophy | 2 2 2 | 3 2.0|
Renal Tubule, Degeneration | | 1 3.0|
Renal Tubule, Dilatation | 2 | 1 2.0|
Renal Tubule, Regeneration | 2 1 3 2 | 8 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + M + + + + + + M + + + + + + A A + + + + + + + +| 44 |
Edema | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7| |
DAY ON TEST | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3| |
| 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 3 3 3 3 2 3 3 3 | 19 2.6|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
40.0 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + + + + A + + M + + + + + + + + +|
Cyst | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Mucosa, Necrosis | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
Duodenum, Amyloid Deposition | |
Ileum, Amyloid Deposition | 4 |
Jejunum, Amyloid Deposition | 2 |
Jejunum, Peyer's Patch, Hyperplasia, | |
Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | X |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 3 3 |
Infiltration Cellular, Mononuclear | |
Cell | 3 |
Inflammation, Chronic | 3 2 3 2 2 3 3 2 |
Inflammation, Chronic Active | |
Bile Duct, Cyst | |
Hepatocyte, Cytoplasmic Alteration | 3 |
Hepatocyte, Karyomegaly | 3 |
Hepatocyte, Necrosis | 4 3 2 3 3 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 2 |
Kupffer Cell, Hyperplasia | 3 3 4 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Suppurative | 4 |
Fat, Inflammation, Chronic Active | 3 |
Fat, Mineralization | 2 3 3 |
Fat, Necrosis, Focal | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + I + + + + + + + + + + + + + + + + +|
Atrophy | |
Cytoplasmic Alteration | 4 |
Inflammation, Chronic | 2 |
Acinus, Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Diverticulum | |
Forestomach, Foreign Body | |
Forestomach, Hyperplasia, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
40.0 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Forestomach, Inflammation, Chronic | |
Active | 2 |
Forestomach, Inflammation, | |
Suppurative | 4 |
Glandular, Atrophy | 3 |
Glandular, Inflammation, Suppurative | |
Glandular, Metaplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endocardium, Inflammation, Chronic | |
Active | 3 |
Myocardium, Inflammation, Chronic | 2 |
Myocardium, Inflammation, Chronic | |
Active | 3 |
Myocardium, Mineralization | 4 |
Ventricle, Embolus Bacterial | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Degeneration, Fatty | |
Cortex, Necrosis | 2 |
Medulla, Angiectasis | |
Spindle Cell, Hyperplasia | 3 3 3 3 3 2 2 3 2 3 2 2 3 3 3 3 3 2 3 3 3 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + I + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + M M + + + M + + + M + + + + + M + + + M + + M +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + M + M + + + + + + + + +|
Angiectasis | 3 2 2 |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 3 2 3 3 1 2 1 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Follicle, Dilatation | 3 |
Follicle, Hyperplasia | |
Follicular Cell, Hyperplasia | 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
40.0 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Angiectasis | 3 2 |
Cyst | X X X X X X X X|
Hemorrhage | 3 3 2 3|
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hydrometra | |
Hyperplasia, Cystic | 3 2 4 2 3 2 4 3 3 2 3 4 4 3 3 3 3 3 4 3 3 3|
Hyperplasia, Glandular | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 4 |
Endometrium, Vacuolization | |
Cytoplasmic | |
Mucosa, Metaplasia, Squamous | |
__________________________________________________________________________|
Vagina | + |
Hyperplasia, Squamous | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 |
Hyperplasia, Reticulum Cell | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + M + +|
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Plasma Cell | |
Mandibular, Necrosis, Diffuse | 2 |
Mandibular, Pigmentation | 3 3 3 |
Mediastinal, Hyperplasia, Histiocytic| 4 |
Mesenteric, Angiectasis | 3 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 2 |
Mesenteric, Hemorrhage | 2 2 |
Mesenteric, Hyperplasia, Histiocytic | 3 3 |
Pancreatic, Hyperplasia, Lymphoid | 4 4 |
Pancreatic, Necrosis | 4 |
Renal, Hyperplasia, Lymphoid | 3 2 |
Renal, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | M |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | 2 3 |
Hematopoietic Cell Proliferation | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
40.0 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Erythrocytic | 4 2 3 4 3 |
Hyperplasia, Lymphoid | 3 2 2 |
Red Pulp, Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + M + + + + + + + +|
Atrophy | 3 4 |
Cyst | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 3 3 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Exudate | |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 2 2 3 X |
__________________________________________________________________________|
Skeletal Muscle | + |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Degeneration, Multifocal | 3 |
Cerebellum, Hemorrhage | 3 |
Hippocampus, Necrosis | 2 |
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 |
Meninges, Infiltration Cellular, | |
Polymorphonuclear | 3 |
Thalamus, Degeneration | 2 |
Thalamus, Hemorrhage | 3 |
Thalamus, Mineralization | 3 1 3 1 2 2 3 1 2 2 1|
Ventricle, Hydrocephalus | |
__________________________________________________________________________|
Peripheral Nerve | + + + + M + M + + + + + + + + + + + + + M + + + +|
Degeneration | |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic | 2 2 2 3 2 3 2 2|
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
40.0 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Artery, Mineralization | 2 |
Interstitium, Edema | 2 3 |
__________________________________________________________________________|
Nose | + + + + + M + + + + + + + + + M + + + + + + + + +|
Foreign Body | 3 3 |
Fungus | 3 |
Hemorrhage | 2 |
Inflammation, Suppurative | 2 3 4 3 3 4 3 2 4 4 3 4 3 3 4 3 4 3 4|
Submucosa, Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Middle Ear, Inflammation, Suppurative| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts | 1 3 1 2 1 |
Inflammation, Chronic | 2 2 2 2 3 2 3 2 2 2 2|
Inflammation, Suppurative | 1 |
Metaplasia, Osseous | |
Renal Tubule, Atrophy | 2 2 |
Renal Tubule, Regeneration | 3 2 1 1 |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 3 2 3 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
40.0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + M M + + + + + + + +| 45 |
Cyst | X | 1 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cecum, Mucosa, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Duodenum, Amyloid Deposition | 2 | 1 2.0|
Ileum, Amyloid Deposition | 4 2 | 3 3.3|
Jejunum, Amyloid Deposition | 2 | 2 2.0|
Jejunum, Peyer's Patch, Hyperplasia, | | |
Lymphoid | 4 4 | 3 3.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Clear Cell Focus | | 1 |
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | | 3 2.7|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 3.0|
Inflammation, Chronic | 2 3 2 3 2 | 13 2.5|
Inflammation, Chronic Active | 1 | 1 1.0|
Bile Duct, Cyst | X | 1 |
Hepatocyte, Cytoplasmic Alteration | | 1 3.0|
Hepatocyte, Karyomegaly | | 1 3.0|
Hepatocyte, Necrosis | | 5 3.0|
Hepatocyte, Vacuolization Cytoplasmic| | 4 2.3|
Kupffer Cell, Hyperplasia | | 4 3.3|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Inflammation, Suppurative | | 1 4.0|
Fat, Inflammation, Chronic Active | | 1 3.0|
Fat, Mineralization | | 3 2.7|
Fat, Necrosis, Focal | 2 | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 | 1 1.0|
Cytoplasmic Alteration | | 1 4.0|
Inflammation, Chronic | | 1 2.0|
Acinus, Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 1 2 1 2 | 7 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
40.0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Diverticulum | X | 1 |
Forestomach, Foreign Body | 2 | 1 2.0|
Forestomach, Hyperplasia, Focal | 3 2 2 | 5 2.2|
Forestomach, Inflammation, Chronic | | |
Active | 2 | 2 2.0|
Forestomach, Inflammation, | | |
Suppurative | 2 | 2 3.0|
Glandular, Atrophy | | 1 3.0|
Glandular, Inflammation, Suppurative | 2 | 1 2.0|
Glandular, Metaplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endocardium, Inflammation, Chronic | | |
Active | | 1 3.0|
Myocardium, Inflammation, Chronic | | 1 2.0|
Myocardium, Inflammation, Chronic | | |
Active | | 1 3.0|
Myocardium, Mineralization | | 1 4.0|
Ventricle, Embolus Bacterial | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cortex, Degeneration, Fatty | 2 2 | 2 2.0|
Cortex, Necrosis | | 1 2.0|
Medulla, Angiectasis | 4 | 1 4.0|
Spindle Cell, Hyperplasia | 2 3 3 3 2 3 3 2 2 2 2 2 2 2 3 2 3 2 2 2 3 2 3 2 3| 48 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 1 3 | 7 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + M + + + + + +| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + M + + + + + + M + + + + +| 44 |
Angiectasis | 2 2 2 | 6 2.2|
Pars Distalis, Angiectasis | 1 | 2 1.5|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 2 3 1 2 | 13 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
40.0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 2 | 2 2.0|
Follicle, Dilatation | 4 3 3 3 3 3 3 | 8 3.1|
Follicle, Hyperplasia | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 2 2 3 2 | 6 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 2 | 1 2.0|
Angiectasis | | 2 2.5|
Cyst | X X X X X X X X X X X | 19 |
Hemorrhage | 4 3 2 | 7 2.9|
Inflammation, Suppurative | | 2 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hydrometra | 3 | 1 3.0|
Hyperplasia, Cystic | 4 3 3 3 3 2 2 3 3 3 2 3 3 3 2 3 4 3 2 2 3 3 4| 45 3.0|
Hyperplasia, Glandular | 2 | 2 2.5|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 1 2 2 2 2 | 7 2.4|
Endometrium, Vacuolization | | |
Cytoplasmic | 3 | 1 3.0|
Mucosa, Metaplasia, Squamous | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
Hyperplasia, Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 3.0|
Hyperplasia, Reticulum Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mandibular, Hyperplasia, Lymphoid | 3 3 3 4 | 4 3.3|
Mandibular, Hyperplasia, Plasma Cell | 4 | 1 4.0|
Mandibular, Necrosis, Diffuse | | 1 2.0|
Mandibular, Pigmentation | | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
40.0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hyperplasia, Histiocytic| | 1 4.0|
Mesenteric, Angiectasis | | 1 3.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Mesenteric, Hemorrhage | 2 2 | 4 2.0|
Mesenteric, Hyperplasia, Histiocytic | | 2 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 2 4.0|
Pancreatic, Necrosis | | 1 4.0|
Renal, Hyperplasia, Lymphoid | | 2 2.5|
Renal, Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | |
Granulocytic | | 2 2.5|
Hematopoietic Cell Proliferation | | |
Erythrocytic | 3 4 | 7 3.3|
Hyperplasia, Lymphoid | 3 3 3 3 | 7 2.7|
Red Pulp, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + M + + +| 45 |
Atrophy | | 2 3.5|
Cyst | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Cystic | 1 2 3 | 9 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 2 1 | 3 1.3|
Exudate | 1 | 1 1.0|
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 3 2 3 2 3 3 3 | 14 2.6|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebellum, Degeneration, Multifocal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
40.0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Cerebellum, Hemorrhage | | 1 3.0|
Hippocampus, Necrosis | | 1 2.0|
Meninges, Infiltration Cellular, | | |
Lymphocyte | 2 | 2 2.0|
Meninges, Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
Thalamus, Degeneration | | 1 2.0|
Thalamus, Hemorrhage | | 1 3.0|
Thalamus, Mineralization | 2 2 2 1 2 2 1| 18 1.8|
Ventricle, Hydrocephalus | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + M + + + + + + + + + + + + + + + + + + + M + + +| 45 |
Degeneration | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 3 | 2 2.0|
Inflammation, Chronic | 2 2 2 2 2 2 4 2 3 2 2| 19 2.3|
Inflammation, Suppurative | | 1 4.0|
Artery, Mineralization | | 1 2.0|
Interstitium, Edema | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
Foreign Body | | 2 3.0|
Fungus | | 1 3.0|
Hemorrhage | 3 3 | 3 2.7|
Inflammation, Suppurative | 3 3 3 4 3 3 3 3 3 3 3 3 3 3| 33 3.2|
Submucosa, Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 2 |
Middle Ear, Inflammation, Suppurative| 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts | 1 1| 8 1.5|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 1 3 2 2 2 2 2| 26 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
40.0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 1.0|
Metaplasia, Osseous | 2 | 1 2.0|
Renal Tubule, Atrophy | 2 2 2 | 5 2.0|
Renal Tubule, Regeneration | 1 2 | 6 1.7|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Inflammation, Chronic | 2 2 2 2 | 13 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20.0 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + M|
Muscularis, Inflammation, Chronic | |
__________________________________________________________________________|
Gallbladder | A + + + + + I + + + + + A A + + + + M + + + + M +|
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + + +|
Jejunum, Fibrosis | 3 |
Jejunum, Inflammation, Suppurative | |
Jejunum, Necrosis | 3 |
Jejunum, Peyer's Patch, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 2 |
Inflammation, Suppurative | |
Hepatocyte, Karyomegaly | 3 |
Hepatocyte, Necrosis | 2 1 1 1|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
Kupffer Cell, Hyperplasia | 3 2 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 4 |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 2 2 2 |
__________________________________________________________________________|
Stomach | A + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Hyperplasia, Focal | 3 1 |
Forestomach, Inflammation, Chronic | |
Active | 3 |
Forestomach, Mineralization | 2 |
Forestomach, Mucosa, Hyperplasia, | |
Focal | 3 |
Glandular, Cyst | |
Glandular, Hemorrhage | |
Glandular, Metaplasia, Squamous | |
Glandular, Mineralization | 2 |
Glandular, Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20.0 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic Active, | |
Multiple | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | X |
Artery, Mineralization | |
Endocardium, Inflammation, | |
Suppurative | |
Myocardium, Inflammation, Chronic | |
Active | 2 |
Pericardium, Inflammation, Chronic | |
Active | 3 |
Valve, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Cortex, Degeneration, Fatty | 2 |
Cortex, Developmental Malformation | X|
Cortex, Hyperplasia, Focal | 2 |
Cortex, Necrosis | 2 |
Cortex, Vacuolization Cytoplasmic | 2 |
Spindle Cell, Hyperplasia | 3 2 3 2 3 2 2 2 3 2 2 3 3 3 2 2 2 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M M + + + + + M M + + M + + + + + + + + + M +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + M + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Hyperplasia | 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + M + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 2 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 1 |
Ultimobranchial Cyst | |
Follicle, Dilatation | 3 3 3 3 3 2 |
Follicular Cell, Hyperplasia | 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Foreign Body | 2 2 |
Hemorrhage | 4 |
Inflammation, Chronic Active | 4 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20.0 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + I + + + + + +|
Cyst | X X X X X X |
Hemorrhage | |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | |
Mineralization | 2 |
__________________________________________________________________________|
Oviduct | |
Inflammation, Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrometra | |
Hyperplasia, Cystic | 3 3 2 3 3 3 3 2 4 3 2 2 2 3 3 3 4 3 3 3 4 3|
Inflammation, Suppurative | 3 2 1 2 |
Endometrium, Edema | 2 |
Mucosa, Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 |
Infiltration Cellular, Mononuclear | |
Cell | |
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Inflammation, Suppurative | 2 |
Iliac, Hyperplasia, Plasma Cell | |
Mandibular, Hyperplasia, Histiocytic | |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Plasma Cell | |
Mandibular, Pigmentation | 2 |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Histiocytic| |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Inflammation, | |
Suppurative | 3 |
Mesenteric, Hematopoietic Cell | |
Proliferation | |
Mesenteric, Hemorrhage | 3 |
Mesenteric, Hyperplasia, Histiocytic | |
Mesenteric, Hyperplasia, Lymphoid | 2 3 |
Mesenteric, Hyperplasia, Plasma Cell | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20.0 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 2 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 2 2 2 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 3 |
Hyperplasia, Megakaryocyte | |
Necrosis | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + M + + + + + + + + + + +|
Atrophy | 2 3 |
Hyperplasia, Lymphoid | 3 |
Mineralization | 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 |
Inflammation, Granulomatous | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 2 2 2 2 2 3|
__________________________________________________________________________|
Skeletal Muscle | + + |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Hemorrhage | |
Cerebrum, Hemorrhage | |
Thalamus, Mineralization | 1 2 2 1 1 1 2 2 2 1 1 2 1 3 2 |
Vein, Adventitia, Infiltration | |
Cellular, Lymphocyte | |
Ventricle, Mineralization | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + M + + + + + + + + + + + + + + +|
Degeneration | |
Infiltration Cellular, Plasma Cell | 1 |
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 4 |
Infiltration Cellular, Histiocyte | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20.0 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 2 2 2 2 3 2 2 3 2 2 2 |
Inflammation, Suppurative | 4 |
Alveolar Epithelium, Hyperplasia | |
Artery, Inflammation, Chronic Active | |
Artery, Inflammation, Suppurative | 4 |
Pleura, Inflammation, Chronic | |
Pleura, Inflammation, Chronic Active | 3 |
Pleura, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Nose | + + + + + M + + + + M M + + + + + + + + + + + + +|
Foreign Body | 3 3 |
Fungus | |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 1 3 4 4 4 3 2 3 3 2 3 3|
Mucosa, Atrophy | |
Mucosa, Necrosis | |
__________________________________________________________________________|
Trachea | A + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts | 2 2 1 1 1 1 1 1 |
Cyst | X |
Glomerulosclerosis | |
Hydronephrosis | |
Infarct | 3 |
Inflammation, Chronic | 3 2 1 1 2 2 2 3 2 3 2 2 |
Inflammation, Suppurative | |
Metaplasia, Osseous | 3 2 |
Pigmentation | 3 |
Glomerulus, Inflammation, Chronic | |
Active | |
Renal Tubule, Atrophy | |
Renal Tubule, Mineralization | 1 |
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | A + + M + + + + + + + + + A M + + + + + + M + + +|
Inflammation, Chronic | 2 3 2 3 2 2 3|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3| |
| 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
20.0 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Muscularis, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M + + + + + + I + + + + + M + + +| 41 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Jejunum, Fibrosis | | 1 3.0|
Jejunum, Inflammation, Suppurative | 3 | 1 3.0|
Jejunum, Necrosis | | 1 3.0|
Jejunum, Peyer's Patch, Hyperplasia, | | |
Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 4 4 2 4 | 5 3.4|
Inflammation, Chronic | 2 2 1 2 | 5 1.8|
Inflammation, Chronic Active | 3 | 3 2.3|
Inflammation, Suppurative | 4 | 1 4.0|
Hepatocyte, Karyomegaly | | 1 3.0|
Hepatocyte, Necrosis | 3 1 4 2 | 8 1.9|
Hepatocyte, Vacuolization Cytoplasmic| | 2 2.0|
Kupffer Cell, Hyperplasia | 3 2 3 | 5 2.6|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 10 |
Inflammation, Chronic | 4 | 2 3.5|
Inflammation, Chronic Active | 3 | 1 3.0|
Inflammation, Suppurative | 4 | 2 4.0|
Fat, Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 3 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 6 1.8|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Forestomach, Hyperplasia, Focal | 3 3 2 3| 6 2.5|
Forestomach, Inflammation, Chronic | | |
Active | 2 | 2 2.5|
Forestomach, Mineralization | | 1 2.0|
Forestomach, Mucosa, Hyperplasia, | | |
Focal | | 1 3.0|
Glandular, Cyst | X X | 2 |
Glandular, Hemorrhage | 3 | 1 3.0|
Glandular, Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3| |
| 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
20.0 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Glandular, Mineralization | | 1 2.0|
Glandular, Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Inflammation, Chronic Active, | | |
Multiple | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | X | 2 |
Artery, Mineralization | 3 | 1 3.0|
Endocardium, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Myocardium, Inflammation, Chronic | | |
Active | 2 | 2 2.0|
Pericardium, Inflammation, Chronic | | |
Active | | 1 3.0|
Valve, Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 3 | 2 3.0|
Cortex, Degeneration, Fatty | 3 | 2 2.5|
Cortex, Developmental Malformation | X X | 3 |
Cortex, Hyperplasia, Focal | | 1 2.0|
Cortex, Necrosis | | 1 2.0|
Cortex, Vacuolization Cytoplasmic | | 1 2.0|
Spindle Cell, Hyperplasia | 3 3 3 2 3 2 2 3 2 2 2 3 2 3 3 3 3 2 3 3 2 2| 43 2.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 43 |
Cyst | X X| 3 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + M + + M + + + + +| 45 |
Angiectasis | 2 | 2 2.0|
Pars Distalis, Hyperplasia | 1 3 1 2 2 3 2 | 11 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Lymphocyte | 3 2 | 4 2.5|
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
Ultimobranchial Cyst | X | 1 |
Follicle, Dilatation | 3 2| 8 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3| |
| 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
20.0 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | 2 3 2 | 6 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Foreign Body | | 2 2.0|
Hemorrhage | | 1 4.0|
Inflammation, Chronic Active | | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | X X X X X X X X X X| 16 |
Hemorrhage | 3| 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | 4 4 4 4 4 | 5 4.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Hydrometra | 2 | 1 2.0|
Hyperplasia, Cystic | 3 3 3 4 3 2 2 2 2 3 2 2 2 3 2 2 4 2 2| 41 2.7|
Inflammation, Suppurative | 3 3 2 4 3 2 3 2 2| 13 2.5|
Endometrium, Edema | | 1 2.0|
Mucosa, Metaplasia, Squamous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 4 4 4 3 | 10 3.2|
Infiltration Cellular, Mononuclear | | |
Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bronchial, Inflammation, Suppurative | | 1 2.0|
Iliac, Hyperplasia, Plasma Cell | 3 3 3 | 3 3.0|
Mandibular, Hyperplasia, Histiocytic | 2 | 1 2.0|
Mandibular, Hyperplasia, Lymphoid | 3 2 | 2 2.5|
Mandibular, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Mandibular, Pigmentation | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3| |
| 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
20.0 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Hyperplasia, Histiocytic| 2 | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| 2 3 | 2 2.5|
Mediastinal, Inflammation, | | |
Suppurative | | 1 3.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 4 3 | 2 3.5|
Mesenteric, Hemorrhage | 2 2 2 2| 5 2.2|
Mesenteric, Hyperplasia, Histiocytic | 4 | 1 4.0|
Mesenteric, Hyperplasia, Lymphoid | 3 | 3 2.7|
Mesenteric, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Renal, Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | 3 3 4 3 3 2 | 8 2.8|
Hematopoietic Cell Proliferation | | |
Erythrocytic | 2 3 4 3 | 8 2.5|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 3 | 4 3.0|
Hyperplasia, Megakaryocyte | 3 | 1 3.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + M + + + + + + + + M M + + + + + +| 43 |
Atrophy | 3 2 | 4 2.5|
Hyperplasia, Lymphoid | | 1 3.0|
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + + M + + + + + + + +| 48 |
Hyperplasia, Cystic | 2 2 2 2 2 1 | 7 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Acanthosis | | 2 1.5|
Inflammation, Granulomatous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 2 3 2 2 3 2| 15 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3| |
| 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
20.0 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebellum, Hemorrhage | 3 | 1 3.0|
Cerebrum, Hemorrhage | 3 | 1 3.0|
Thalamus, Mineralization | 2 1 3 3 3 1 2 1 2 2 | 25 1.8|
Vein, Adventitia, Infiltration | | |
Cellular, Lymphocyte | 2 | 1 2.0|
Ventricle, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration | 2 | 1 2.0|
Infiltration Cellular, Plasma Cell | | 1 1.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | | 1 4.0|
Infiltration Cellular, Histiocyte | 1 2 | 2 1.5|
Inflammation, Chronic | 2 2 2 2 2 | 17 2.1|
Inflammation, Suppurative | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 3 | 1 3.0|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Artery, Inflammation, Suppurative | | 1 4.0|
Pleura, Inflammation, Chronic | 2 | 1 2.0|
Pleura, Inflammation, Chronic Active | | 1 3.0|
Pleura, Inflammation, Suppurative | 2 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + M + + + + M M + + + + + + + +| 44 |
Foreign Body | 3 3 | 4 3.0|
Fungus | 3 | 1 3.0|
Inflammation, Chronic | 3| 1 3.0|
Inflammation, Suppurative | 3 3 3 2 3 4 3 3 3 4 2 3 2 2 4 3| 29 2.9|
Mucosa, Atrophy | 3| 1 3.0|
Mucosa, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3| |
| 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
20.0 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts | 1 2 | 10 1.3|
Cyst | X | 2 |
Glomerulosclerosis | 2 2 | 2 2.0|
Hydronephrosis | 2 | 1 2.0|
Infarct | 2 | 2 2.5|
Inflammation, Chronic | 2 2 2 3 3 2 2 2 2 2 2 2 | 24 2.1|
Inflammation, Suppurative | 3 2 | 2 2.5|
Metaplasia, Osseous | 2 | 3 2.3|
Pigmentation | | 1 3.0|
Glomerulus, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Renal Tubule, Atrophy | 2| 1 2.0|
Renal Tubule, Mineralization | 2 | 2 1.5|
Renal Tubule, Regeneration | 3 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Inflammation, Chronic | 2 2 2 3 2 2 | 13 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|
| 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + M + M + + + + I + A + + M + + M + +|
Concretion | X |
Hemorrhage | 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +|
Cecum, Hyperplasia, Lymphoid | 3 3 |
Cecum, Mucosa, Fibrosis | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +|
Ileum, Peyer's Patch, Hyperplasia, | |
Lymphoid | 2 3 2 |
Mucosa, Ileum, Dysplasia | 3|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Clear Cell Focus | |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 3 |
Hepatocyte, Anisokaryosis | |
Hepatocyte, Cytomegaly | 2 |
Hepatocyte, Karyomegaly | |
Hepatocyte, Necrosis | 4 3 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 3 3 2 |
Kupffer Cell, Hyperplasia | 3 3 |
Kupffer Cell, Pigmentation | 3 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Suppurative | 3 |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Atypia Cellular, Focal | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 2 1 3 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Cyst | |
Forestomach, Hyperplasia | 3 2 2 3 |
Forestomach, Inflammation, Chronic | 3 2 |
Forestomach, Inflammation, Chronic | |
Active | 3 |
Forestomach, Mineralization | 2 |
Forestomach, Ulcer | 2 3 |
Forestomach, Mucosa, Hyperplasia | 2 |
Glandular, Cyst | |
Glandular, Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|
| 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Glandular, Inflammation, Chronic | |
Active | |
Glandular, Inflammation, Suppurative | 2 |
Glandular, Metaplasia, Squamous | |
Glandular, Mineralization | 2 |
__________________________________________________________________________|
Tooth | + + + + |
Developmental Malformation | X X X |
Peridontal Tissue, Fibrosis | |
Peridontal Tissue, Inflammation, | |
Chronic Active | 3 |
Peridontal Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic Active | 3 |
Aorta, Embolus Bacterial | |
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | |
Thrombosis | |
Coronary Artery, Inflammation, | |
Suppurative | |
Coronary Artery, Necrosis, Fibrinoid | |
Endocardium, Inflammation, Chronic | |
Epicardium, Fibrosis | |
Epicardium, Inflammation, Chronic | |
Myocardium, Fibrosis | |
Myocardium, Inflammation, Chronic | |
Myocardium, Inflammation, Suppurative| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Cortex, Hyperplasia, Focal | 2|
Cortex, Hyperplasia | 2 |
Cortex, Infiltration Cellular, | |
Lymphocyte | 2 |
Medulla, Hyperplasia | |
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | |
Hyperplasia | 2 2 3 2 3 3 4 3|
__________________________________________________________________________|
Parathyroid Gland | + M + M I + + + M M M M M M + + + + + M M + M M M|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|
| 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Pituitary Gland | + + + M + M + M + + + + + M M + M M + + + I + + +|
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + M + M + + + + + + M + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1|
Follicle, Crystals | 2|
Follicle, Dilatation | 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Foreign Body | |
Hemorrhage | 4 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + M|
Dilatation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + |
Ectasia | 4 3 3 3 4 |
Inflammation, Chronic | 1 4 3 2 |
Inflammation, Chronic Active | 4 |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Prostate | + + + + M + + + + + + + + + + + M + + + + + + + +|
Inflammation, Chronic | 3 3 2 |
Inflammation, Suppurative | 4 3 3 3 |
__________________________________________________________________________|
Seminal Vesicle | A + + + + + |
Amyloid Deposition | 3 |
Dilatation | 3 |
Fibrosis | 3 3 |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Mineralization | 2 |
Seminiferous Tubule, Atrophy | 3 |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Histiocytic | 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|
| 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 4 3 3 2 3 2|
Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + M + + + + + + + + M M + + + + +|
Iliac, Hyperplasia, Plasma Cell | 4 |
Inguinal, Fibrosis | 2 |
Inguinal, Hyperplasia, Histiocytic | 4 |
Mandibular, Hyperplasia, Plasma Cell | |
Mesenteric, Atrophy | 4 |
Mesenteric, Hematopoietic Cell | |
Proliferation | |
Mesenteric, Hemorrhage | 2 2 2 2 3 2 2 2 3 |
Mesenteric, Hyperplasia, Histiocytic | |
Mesenteric, Hyperplasia, Lymphoid | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hematopoietic Cell Proliferation | |
Erythrocytic | 3 2 3 2 2|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + M M + M + + + + M M + M + + + M + M + + M + M|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 2 2 2 |
Exudate | 2 |
Fibrosis | 3 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | |
Inflammation, Chronic Active, | |
Multiple | 2 |
Inflammation, Suppurative | |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Proliferation | |
__________________________________________________________________________|
Skeletal Muscle | + + + |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|
| 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 3 1 2 1 3 3 2 2 2 1 3|
Venule, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + M M M I I M + + + + + + + M M M + + + +|
Inflammation, Chronic | 2 |
Inflammation, Subacute | 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 2 3 |
Inflammation, Chronic | 2 2 2 2 2 2 3 2 2 2 2 |
Inflammation, Suppurative | |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | 2 |
Interstitium, Edema | 2 2 2 |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + M M + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 3 3 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Lacrimal Gland | M |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Bacterium | |
Calculus Micro Observation Only | 2 |
Casts | 2 4 3 |
Cyst | |
Infarct | |
Inflammation, Chronic | 2 2 1 3 3 4 2 3 2 3 2 |
Inflammation, Suppurative | 4 2 |
Metaplasia, Osseous | |
Renal Tubule, Atrophy | 4 |
Renal Tubule, Degeneration | 3 |
Renal Tubule, Dilatation | 3 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|
| 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Mineralization | 1 |
Renal Tubule, Regeneration | 1 1 1 2 1 1 1 3 2 3 1 1|
Renal Tubule, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Urethra | + + |
Angiectasis | 4 |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Calculus Gross Observation | X |
Inflammation, Chronic | 4 4 |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 3 |
Mucosa, Hyperplasia | 3 4 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| |
| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + + M + + + A + + + + + + + + + + + + + +| 40 |
Concretion | X | 2 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cecum, Hyperplasia, Lymphoid | | 2 3.0|
Cecum, Mucosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ileum, Peyer's Patch, Hyperplasia, | | |
Lymphoid | | 3 2.3|
Mucosa, Ileum, Dysplasia | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | | 1 2.0|
Clear Cell Focus | X X | 2 |
Hematopoietic Cell Proliferation | 2 2 4 | 3 2.7|
Inflammation, Chronic | 3 | 2 3.0|
Hepatocyte, Anisokaryosis | 3 | 1 3.0|
Hepatocyte, Cytomegaly | 2 | 2 2.0|
Hepatocyte, Karyomegaly | 3 3 2 | 3 2.7|
Hepatocyte, Necrosis | 4 | 3 3.7|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 | 7 2.3|
Kupffer Cell, Hyperplasia | 3 | 3 3.0|
Kupffer Cell, Pigmentation | 3 | 3 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Inflammation, Suppurative | | 1 3.0|
Fat, Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Atypia Cellular, Focal | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 3 3 2 | 13 2.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Cyst | X | 1 |
Forestomach, Hyperplasia | 1 2 3 3 3 2 | 10 2.4|
Forestomach, Inflammation, Chronic | 2 | 3 2.3|
Forestomach, Inflammation, Chronic | | |
Active | 2 3 3 | 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| |
| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Forestomach, Mineralization | | 1 2.0|
Forestomach, Ulcer | | 2 2.5|
Forestomach, Mucosa, Hyperplasia | | 1 2.0|
Glandular, Cyst | X | 1 |
Glandular, Dysplasia | 3 | 2 2.5|
Glandular, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Glandular, Inflammation, Suppurative | 2 2 | 3 2.0|
Glandular, Metaplasia, Squamous | 2 | 1 2.0|
Glandular, Mineralization | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + + + | 7 |
Developmental Malformation | X | 4 |
Peridontal Tissue, Fibrosis | 3 | 1 3.0|
Peridontal Tissue, Inflammation, | | |
Chronic Active | 3 | 2 3.0|
Peridontal Tissue, Inflammation, | | |
Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 3 |
Inflammation, Chronic Active | | 1 3.0|
Aorta, Embolus Bacterial | X X | 2 |
Aorta, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Embolus Bacterial | X | 1 |
Thrombosis | 4| 1 4.0|
Coronary Artery, Inflammation, | | |
Suppurative | 4 | 1 4.0|
Coronary Artery, Necrosis, Fibrinoid | 4 | 1 4.0|
Endocardium, Inflammation, Chronic | 3 | 1 3.0|
Epicardium, Fibrosis | 2 | 1 2.0|
Epicardium, Inflammation, Chronic | 1 | 1 1.0|
Myocardium, Fibrosis | 2 | 1 2.0|
Myocardium, Inflammation, Chronic | 3 | 1 3.0|
Myocardium, Inflammation, Suppurative| 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + M + + + + + + + + + + + + M + +| 48 |
Developmental Malformation | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| |
| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cortex, Hyperplasia, Focal | 2 | 2 2.0|
Cortex, Hyperplasia | | 1 2.0|
Cortex, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Medulla, Hyperplasia | 3 2 | 2 2.5|
Spindle Cell, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 2 | 27 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dysplasia | 2 | 1 2.0|
Hyperplasia | 2 3 3 3 2 3 2| 15 2.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + M + + M M M I + + + + + + + + M M| 28 |
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + M + + + +| 40 |
Pars Distalis, Cyst | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + I + + + + + + + + + + + + + + + + + + + + + I| 45 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Follicle, Crystals | | 1 2.0|
Follicle, Dilatation | 3 3 3 3 | 5 2.8|
Follicular Cell, Hyperplasia | 2 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Foreign Body | 2 | 1 2.0|
Hemorrhage | | 1 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + M + + + +| 20 |
Ectasia | 4 4 3 3 4 3 3 3 4 | 14 3.4|
Inflammation, Chronic | 2 3 2 3 2 4 | 10 2.6|
Inflammation, Chronic Active | | 1 4.0|
Inflammation, Suppurative | 3 3 2 4 3 4 4| 9 3.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Inflammation, Chronic | 2 2 2 2 | 7 2.3|
Inflammation, Suppurative | | 4 3.3|
__________________________________________________________________________|____________|
Seminal Vesicle | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| |
| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Amyloid Deposition | | 1 3.0|
Dilatation | | 1 3.0|
Fibrosis | | 2 3.0|
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Mineralization | | 1 2.0|
Seminiferous Tubule, Atrophy | 3 1| 3 2.3|
Seminiferous Tubule, Mineralization | 2 2 1 2| 4 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia | 2 2 4 | 9 2.8|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Iliac, Hyperplasia, Plasma Cell | | 1 4.0|
Inguinal, Fibrosis | | 1 2.0|
Inguinal, Hyperplasia, Histiocytic | 2 | 2 3.0|
Mandibular, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mesenteric, Atrophy | | 1 4.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 2 2 3 3 | 4 2.5|
Mesenteric, Hemorrhage | 3 3 3 3 2 2 3 2 3 3| 19 2.5|
Mesenteric, Hyperplasia, Histiocytic | 3 | 1 3.0|
Mesenteric, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | | |
Granulocytic | 4 3 | 2 3.5|
Hematopoietic Cell Proliferation | | |
Erythrocytic | 3 2 3 2 2| 10 2.4|
Hyperplasia, Lymphoid | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + M M + + + + + M + + M| 35 |
Cyst | X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| |
| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 3 2 2 3 2 3| 12 2.3|
Exudate | | 1 2.0|
Fibrosis | 2 2 | 3 2.3|
Inflammation, Chronic | 2 3 2 | 4 2.5|
Inflammation, Chronic Active | 3 | 1 3.0|
Inflammation, Chronic Active, | | |
Multiple | | 1 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 3| 1 3.0|
Proliferation | 3| 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 5 |
Inflammation, Chronic | 2 2 | 2 2.0|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | | 2 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thalamus, Mineralization | 1 1 2 2 2 2 2 2| 20 2.0|
Venule, Infiltration Cellular, | | |
Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + M + + + + + + + + + + + + + + + + + + + + + +| 40 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Subacute | 3 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | | 3 2.3|
Inflammation, Chronic | 2 1 2 3 3 3 1 2 2 2 2 2 2 2 2 2 | 27 2.1|
Inflammation, Suppurative | 2 | 1 2.0|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Artery, Mineralization | | 1 2.0|
Interstitium, Edema | 2 | 4 2.0|
Pleura, Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| |
| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + M + + + +| 46 |
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 3 3 3 3 2 3 3 2 2 3 3| 16 2.6|
__________________________________________________________________________|____________|
Trachea | + + + I + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 6 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 | 1 2.0|
Bacterium | 3 | 1 3.0|
Calculus Micro Observation Only | | 1 2.0|
Casts | 3 3| 5 3.0|
Cyst | X X X| 3 |
Infarct | 2 | 1 2.0|
Inflammation, Chronic | 3 2 4 2 2 3 2 2 3 1 3 3 2 1 2 2 2 3| 29 2.4|
Inflammation, Suppurative | 3 | 3 3.0|
Metaplasia, Osseous | 1 | 1 1.0|
Renal Tubule, Atrophy | 2 | 2 3.0|
Renal Tubule, Degeneration | | 1 3.0|
Renal Tubule, Dilatation | | 2 3.0|
Renal Tubule, Mineralization | 1 | 2 1.0|
Renal Tubule, Regeneration | 1 2 1 1 1 1 2 1 1 1 1 2 1 3| 26 1.4|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urethra | | 2 |
Angiectasis | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Calculus Gross Observation | | 1 |
Inflammation, Chronic | 2 2 | 4 3.0|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Mucosa, Hyperplasia | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|
| 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + M M + + M + + + + A + M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +|
Cecum, Serosa, Ectopic Tissue | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + + + + + + + + +|
Ileum, Peyer's Patch, Hyperplasia, | |
Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | X X |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Focal | 2 |
Inflammation, Chronic | 3 2 2 |
Mineralization | |
Hepatocyte, Karyomegaly | |
Hepatocyte, Necrosis | 3 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 2 2 1|
Kupffer Cell, Hyperplasia | |
Kupffer Cell, Pigmentation | |
Vein, Thrombosis | |
Vein, Adventitia, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + + +|
Fibrosis | 3|
Mineralization | 3|
Artery, Inflammation, Chronic | 3 |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + I A + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Hyperplasia | 3 3 2 |
Forestomach, Inflammation, Chronic | 2 |
Forestomach, Inflammation, Chronic | |
Active | |
Glandular, Cyst | X |
Glandular, Mineralization | |
__________________________________________________________________________|
Tooth | + + + |
Developmental Malformation | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|
| 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | |
Coronary Artery, Inflammation, | |
Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X X |
Cortex, Atrophy | |
Cortex, Hyperplasia, Focal | |
Medulla, Hyperplasia | |
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + M + A + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 3 2 3 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + M + + + I + + + + + + + + +|
Crystals | 3 |
Cyst | X |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + I + + + + + + + + I + + + + +|
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Follicle, Dilatation | 2 4 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Dilatation | |
__________________________________________________________________________|
Epididymis | M + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Ectasia | 3 2 2 3 |
Inflammation, Chronic | 2 3 3 3 |
Inflammation, Suppurative | 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + +|
Dilatation | |
Fibrosis | 3 3|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|
| 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 2|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Histiocytic | 3 |
Inguinal, Hyperplasia, Plasma Cell | 3 |
Inguinal, Pigmentation | 2 3 |
Lymphatic, Mandibular, Ectasia | |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Plasma Cell | 3 3 |
Mesenteric, Angiectasis | 4 |
Mesenteric, Atrophy | |
Mesenteric, Congestion | 3 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 2 2 3 |
Mesenteric, Hemorrhage | 2 2 4 3 2 3 |
Mesenteric, Hyperplasia, Histiocytic | 3 |
Mesenteric, Hyperplasia, Lymphoid | 3 |
Mesenteric, Hyperplasia, Plasma Cell | 3 |
Mesenteric, Infiltration Cellular, | |
Mast Cell | 2 |
Mesenteric, Infiltration Cellular, | |
Megakaryocyte | 3 |
Renal, Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | 3 4 4 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 3 3 2 3 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Necrosis, Focal | 4 |
__________________________________________________________________________|
Thymus | + + + I + M M + + M + + + + + + M M + + + M M + +|
Cyst | X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|
| 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Acanthosis | 1 2 3 3 3 |
Edema | |
Erosion | 3 3 |
Exudate | |
Fibrosis | 4 |
Foreign Body | 3 |
Fungus | |
Hyperkeratosis | 2 |
Inflammation, Chronic | 3 2 |
Inflammation, Chronic Active | 4 |
Inflammation, Granulomatous | 3 |
Inflammation, Suppurative | |
Ulcer | 2 4 |
Sebaceous Gland, Hyperplasia | |
Subcutaneous Tissue, Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
Foreign Body | |
Hemorrhage | |
Inflammation, Chronic | 2 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Vacuolization Cytoplasmic | |
Hippocampus, Infiltration Cellular, | |
Lymphocyte | 1 |
Thalamus, Mineralization | 2 2 2 2 2 3 2 2 1|
__________________________________________________________________________|
Peripheral Nerve | M + + + + + + M + + + + + + + + + + + + + M + + +|
Degeneration | |
Inflammation, Chronic | 4 |
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Eosinophil | |
Infiltration Cellular, Histiocyte | 3 3 |
Inflammation, Chronic | 2 2 2 2 2 2 |
Inflammation, Suppurative | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|
| 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Thrombosis | X |
Bronchus, Foreign Body | |
Capillary, Infiltration Cellular, | |
Polymorphonuclear | |
Interstitium, Edema | 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + M + + + +|
Fungus | 3 |
Inflammation, Suppurative | 3 1 3 2 3 3 |
Mucosa, Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Submucosa, Cyst | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Hyperplasia | 3 |
Cornea, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + |
Cyst | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Casts | 2 2 1 2 |
Cyst | X X|
Glomerulosclerosis | 2 |
Hydronephrosis | 2 |
Infarct | 2 |
Inflammation, Chronic | 2 4 2 2 3 2 1 2 1 2 2 2 2 2 2 |
Inflammation, Suppurative | 2 1 |
Cortex, Necrosis | |
Renal Tubule, Atrophy | 4 2 |
Renal Tubule, Mineralization | |
Renal Tubule, Regeneration | 1 1 1 2 1 2 2 3 1 1 2 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Fibrosis | 3 |
Hemorrhage | |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2| |
| 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
20.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + M +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + M M + + + M + + M + + + M M + + + + + + + M| 37 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cecum, Serosa, Ectopic Tissue | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ileum, Peyer's Patch, Hyperplasia, | | |
Lymphoid | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Clear Cell Focus | | 2 |
Eosinophilic Focus | X | 1 |
Hematopoietic Cell Proliferation | 2 3 2 | 4 2.5|
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic | 3 2 | 5 2.4|
Mineralization | 4 | 1 4.0|
Hepatocyte, Karyomegaly | 2 2 | 2 2.0|
Hepatocyte, Necrosis | 4 | 3 3.3|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 3 | 10 2.1|
Kupffer Cell, Hyperplasia | X| 1 |
Kupffer Cell, Pigmentation | 4 | 1 4.0|
Vein, Thrombosis | 3 | 1 3.0|
Vein, Adventitia, Fibrosis | 3| 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Fibrosis | | 1 3.0|
Mineralization | | 1 3.0|
Artery, Inflammation, Chronic | | 1 3.0|
Fat, Necrosis, Focal | 3 3 | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 3 | 8 2.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Hyperplasia | 2 1 2 2 2 3 | 9 2.2|
Forestomach, Inflammation, Chronic | | 1 2.0|
Forestomach, Inflammation, Chronic | | |
Active | 2 2 | 2 2.0|
Glandular, Cyst | | 1 |
Glandular, Mineralization | 3 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Tooth | + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2| |
| 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
20.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Developmental Malformation | X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coronary Artery, Inflammation, | | |
Chronic | 2 | 1 2.0|
Coronary Artery, Inflammation, | | |
Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Developmental Malformation | | 2 |
Cortex, Atrophy | 3 | 1 3.0|
Cortex, Hyperplasia, Focal | 2 | 1 2.0|
Medulla, Hyperplasia | 3 3 | 2 3.0|
Spindle Cell, Hyperplasia | 2 2 2 3 3 3 2 2 2 2 2| 21 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 | 7 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + M + + + + M M + + +| 43 |
Crystals | | 1 3.0|
Cyst | X | 2 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + I M M + + M + + + + + + + M + + + M + + M| 40 |
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Mineralization | 1 | 1 1.0|
Follicle, Dilatation | 3 | 3 3.0|
Follicular Cell, Hyperplasia | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2| |
| 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
20.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + M + + | 11 |
Ectasia | 2 | 5 2.4|
Inflammation, Chronic | 4 3 2 | 7 2.9|
Inflammation, Suppurative | 4 2 | 5 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 2 | 2 2.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 5 |
Dilatation | 4 | 1 4.0|
Fibrosis | | 2 3.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Seminiferous Tubule, Atrophy | 2 2 | 2 2.0|
Seminiferous Tubule, Mineralization | 2 3 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 2 3 3 3 4 | 10 3.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Histiocytic | 3 | 2 3.0|
Inguinal, Hyperplasia, Plasma Cell | 3 | 2 3.0|
Inguinal, Pigmentation | 3 3 | 4 2.8|
Lymphatic, Mandibular, Ectasia | 3 | 1 3.0|
Mandibular, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mandibular, Hyperplasia, Plasma Cell | 3 3 3 | 5 3.0|
Mesenteric, Angiectasis | | 1 4.0|
Mesenteric, Atrophy | 3 | 1 3.0|
Mesenteric, Congestion | | 1 3.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 3 | 4 2.5|
Mesenteric, Hemorrhage | 2 3 4 3 3 2 4 3 | 14 2.9|
Mesenteric, Hyperplasia, Histiocytic | | 1 3.0|
Mesenteric, Hyperplasia, Lymphoid | 4 4 | 3 3.7|
Mesenteric, Hyperplasia, Plasma Cell | | 1 3.0|
Mesenteric, Infiltration Cellular, | | |
Mast Cell | | 1 2.0|
Mesenteric, Infiltration Cellular, | | |
Megakaryocyte | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2| |
| 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
20.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Hyperplasia, Histiocytic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | | |
Granulocytic | 4 3 | 5 3.6|
Hematopoietic Cell Proliferation | | |
Erythrocytic | 2 3 2 3 4 | 9 2.8|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + + + M M + + + + + + + + + + + M + + + M M + +| 36 |
Cyst | X X | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | X 3 3 3 2 4 1 3 2 3 2 3 | 18 2.5|
Edema | 3 | 1 3.0|
Erosion | | 2 3.0|
Exudate | 2 2 | 2 2.0|
Fibrosis | | 1 4.0|
Foreign Body | | 1 3.0|
Fungus | 4 | 1 4.0|
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic | 2 2 3 2 3 | 7 2.4|
Inflammation, Chronic Active | 2 3 | 3 3.0|
Inflammation, Granulomatous | 4 | 2 3.5|
Inflammation, Suppurative | 4 | 1 4.0|
Ulcer | 3 2 X 3 | 6 2.8|
Sebaceous Gland, Hyperplasia | 2 | 1 2.0|
Subcutaneous Tissue, Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + +| 47 |
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + +| 4 |
Foreign Body | 2| 1 2.0|
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Granulomatous | 3| 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2| |
| 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
20.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebrum, Vacuolization Cytoplasmic | 3| 1 3.0|
Hippocampus, Infiltration Cellular, | | |
Lymphocyte | | 1 1.0|
Thalamus, Mineralization | 2 2 2 3 2 3 3 2 2 2 2 3 2 1 2 4| 25 2.2|
__________________________________________________________________________|____________|
Peripheral Nerve | + M + + + + + + + + + M + + + M + + M M + + + + +| 42 |
Degeneration | 2 | 1 2.0|
Inflammation, Chronic | 1 | 2 2.5|
Inflammation, Subacute | 2| 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 3 | 3 3.0|
Infiltration Cellular, Eosinophil | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 3 2 | 5 2.6|
Inflammation, Chronic | 2 2 1 2 2 2 2 3 2 2 2| 17 2.0|
Inflammation, Suppurative | 1 2 2 2| 9 1.9|
Thrombosis | | 1 |
Bronchus, Foreign Body | 2 | 1 2.0|
Capillary, Infiltration Cellular, | | |
Polymorphonuclear | 4 | 1 4.0|
Interstitium, Edema | 2 | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Fungus | 3 | 2 3.0|
Inflammation, Suppurative | 3 3 3 4 3 3 3 3 2 3 | 16 2.8|
Mucosa, Metaplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 | 1 3.0|
Submucosa, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | M | 1 |
Cornea, Hyperplasia | | 1 3.0|
Cornea, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 8 |
Cyst | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2| |
| 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
20.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | 4 | 1 4.0|
Casts | 1 | 5 1.6|
Cyst | | 2 |
Glomerulosclerosis | 1 2 | 3 1.7|
Hydronephrosis | | 1 2.0|
Infarct | | 1 2.0|
Inflammation, Chronic | 2 3 2 2 2 2 2 2 2 3 3| 26 2.2|
Inflammation, Suppurative | 4 | 3 2.3|
Cortex, Necrosis | 4 | 1 4.0|
Renal Tubule, Atrophy | 2 2 | 4 2.5|
Renal Tubule, Mineralization | 4 | 1 4.0|
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1| 22 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Calculus Micro Observation Only | X | 2 |
Fibrosis | | 1 3.0|
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | | 2 2.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|
| 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M M + + + + M + + A + + + + + + M M + + M I + +|
Amyloid Deposition | 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duodenum, Ulcer | |
Ileum, Peyer's Patch, Hyperplasia, | |
Lymphoid | 2|
Serosa, Jejunum, Cyst | X |
Serosa, Jejunum, Inflammation, | |
Granulomatous | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 3 2 |
Inflammation, Chronic Active | 1 |
Bile Duct, Cyst | X |
Hepatocyte, Cytoplasmic Alteration | 2 2 |
Hepatocyte, Karyomegaly | 3 |
Hepatocyte, Necrosis | 1 4 4 |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 3 |
Kupffer Cell, Hyperplasia | 3 3 |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | |
Mineralization | 3 |
Artery, Necrosis | |
Artery, Thrombosis | |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + M + + + + + + + M + + + + + +|
Atrophy | 4 |
Cyst | X X |
Hyperplasia, Focal | |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 2 |
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Hyperplasia | 2 2 |
Forestomach, Inflammation, Chronic | 2 |
Forestomach, Inflammation, Chronic | |
Active | |
Forestomach, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|
| 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Suppurative | |
Forestomach, Mineralization | |
Glandular, Erosion | 2 |
Glandular, Inflammation, Suppurative | 2 |
Glandular, Mineralization | 2 2 |
__________________________________________________________________________|
Tooth | + + + + + + +|
Developmental Malformation | X X X X X X X|
Foreign Body | 3 |
Peridontal Tissue, Inflammation, | |
Chronic Active | 3 |
Peridontal Tissue, Inflammation, | |
Suppurative | 3 3 |
Pulp, Inflammation, Suppurative | 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | 2 |
Myocardium, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Cortex, Hyperplasia, Focal | 2 |
Cortex, Vacuolization Cytoplasmic | 2 2 |
Medulla, Hyperplasia | 2 |
Spindle Cell, Hyperplasia | 2 1 2 2 2 2 2 2 3 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + M + M + + + + + +|
Hyperplasia | 2 2 3 2 2 3|
Infiltration Cellular, Lymphocyte | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + M + M + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | I + + + + + + + M + + + + + + + + + M + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Dilatation | 3 2 3 |
Follicular Cell, Hyperplasia | 3 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|
| 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + I + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + +|
Ectasia | 2 3 3 3 3 3 2|
Inflammation, Chronic | 3 3 3 3 2|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic | 2 4 3 |
Inflammation, Suppurative | 4 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Fibrosis | |
Inflammation, Suppurative | 4 3 |
Pigmentation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
Seminiferous Tubule, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + M + + + + + + + +|
Inguinal, Hyperplasia, Histiocytic | 4 |
Inguinal, Hyperplasia, Plasma Cell | |
Inguinal, Infiltration Cellular, | |
Polymorphonuclear | |
Inguinal, Pigmentation | 3 |
Mandibular, Hyperplasia, Lymphoid | 3 |
Mandibular, Hyperplasia, Plasma Cell | 3 |
Mandibular, Pigmentation | 3 |
Mesenteric, Angiectasis | 3 |
Mesenteric, Atrophy | |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 3 |
Mesenteric, Hemorrhage | 2 3 4 3 4 2 2 3 2 4|
Mesenteric, Hyperplasia, Plasma Cell | 2 |
Mesenteric, Infiltration Cellular, | |
Polymorphonuclear | 3 |
Mesenteric, Lymphatic, Ectasia | 2 |
Renal, Hemorrhage | |
Renal, Hyperplasia, Plasma Cell | |
Renal, Lymphatic, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|
| 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | 2 2 3 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 2 3 3 3 3 |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Megakaryocyte | 3 |
Lymphoid Follicle, Atrophy | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + M + M + M + M M M + M + + + + +|
Atrophy | 3 |
Cyst | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + M + + + + +|
Acanthosis | 3 2 3 2 3 2 3 3 |
Acanthosis, Multiple | |
Edema | 3 3|
Exudate | 2 |
Fibrosis | 2 3 |
Fungus | |
Inflammation, Chronic | 2 2 2 |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | 3 |
Inflammation, Suppurative | 3 3 |
Ulcer | 3 |
Lymphatic, Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 2 3 1 2 2 2 3 2 2 3 2 1 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 3 4 2 2 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|
| 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 1 3 2 3 |
Inflammation, Suppurative | 2 3 |
Alveolar Epithelium, Hyperplasia | |
Glands, Ectasia | |
Interstitium, Edema | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Glands, Cyst | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts | 3 2 1 2 2 3 |
Congestion | |
Cyst | X X X X X X |
Glomerulosclerosis | 2 2 1 |
Hydronephrosis | 2 |
Inflammation, Chronic | 3 3 1 2 1 2 2 4 2 2 1|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | |
Renal Tubule, Atrophy | 2 3 |
Renal Tubule, Mineralization | 1 |
Renal Tubule, Regeneration | 3 1 1 1 3 1 1 3 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Chronic | 2 2 3 |
Inflammation, Chronic Active | |
Mineralization | |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2| |
| 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10.0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M M + + + + + + + + M + + + + + + M + + M I + + +| 35 |
Amyloid Deposition | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duodenum, Ulcer | 3 | 1 3.0|
Ileum, Peyer's Patch, Hyperplasia, | | |
Lymphoid | 3 | 2 2.5|
Serosa, Jejunum, Cyst | | 1 |
Serosa, Jejunum, Inflammation, | | |
Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X | 1 |
Hematopoietic Cell Proliferation | 2 2 4 | 3 2.7|
Inflammation, Chronic | 2 | 3 2.3|
Inflammation, Chronic Active | | 1 1.0|
Bile Duct, Cyst | | 1 |
Hepatocyte, Cytoplasmic Alteration | | 2 2.0|
Hepatocyte, Karyomegaly | 2 | 2 2.5|
Hepatocyte, Necrosis | 4 | 4 3.3|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 | 6 2.0|
Kupffer Cell, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + +| 6 |
Hemorrhage | 4| 1 4.0|
Mineralization | | 1 3.0|
Artery, Necrosis | 3 | 1 3.0|
Artery, Thrombosis | X| 1 |
Fat, Necrosis, Focal | 3 4 | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | | 1 4.0|
Cyst | | 2 |
Hyperplasia, Focal | 3 | 1 3.0|
Inflammation, Chronic | | 2 2.0|
Inflammation, Suppurative | | 1 2.0|
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 2 3 2 3 | 8 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2| |
| 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10.0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Forestomach, Hyperplasia | 3 3 3 | 5 2.6|
Forestomach, Inflammation, Chronic | | 1 2.0|
Forestomach, Inflammation, Chronic | | |
Active | 3 2| 2 2.5|
Forestomach, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Forestomach, Mineralization | 3 | 1 3.0|
Glandular, Erosion | 2 | 2 2.0|
Glandular, Inflammation, Suppurative | 2 | 2 2.0|
Glandular, Mineralization | 2 | 3 2.0|
__________________________________________________________________________|____________|
Tooth | + + +| 10 |
Developmental Malformation | X X X| 10 |
Foreign Body | | 1 3.0|
Peridontal Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
Peridontal Tissue, Inflammation, | | |
Suppurative | | 2 3.0|
Pulp, Inflammation, Suppurative | | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coronary Artery, Inflammation, | | |
Chronic | 2 | 2 2.0|
Myocardium, Inflammation, Chronic | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X | 1 |
Cortex, Hyperplasia, Focal | 2 2 2 | 4 2.0|
Cortex, Vacuolization Cytoplasmic | | 2 2.0|
Medulla, Hyperplasia | | 1 2.0|
Spindle Cell, Hyperplasia | 2 2 2 1 2 2 2 2 2 3 2 2 2 2 2| 27 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 3 2 4 2 4 2 2 | 13 2.5|
Infiltration Cellular, Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M I M + + + M + + + + M + + + + + + + M M| 40 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M I + + + + + + + + + + M + + + + + + +| 44 |
Pars Distalis, Cyst | X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2| |
| 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10.0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Dilatation | | 3 2.7|
Follicular Cell, Hyperplasia | | 3 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 2 |
Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | | 1 3.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + +| 14 |
Ectasia | 3 4 3 3 4| 12 3.0|
Inflammation, Chronic | 4 | 6 3.0|
Inflammation, Suppurative | 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Dilatation | | 1 3.0|
Inflammation, Chronic | 4 | 4 3.3|
Inflammation, Suppurative | 4 | 3 3.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 5 |
Fibrosis | 3 | 1 3.0|
Inflammation, Suppurative | 4 | 3 3.7|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Seminiferous Tubule, Atrophy | 2 3 2 2 1 2 2| 7 2.0|
Seminiferous Tubule, Mineralization | 2 1 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 3 2| 7 2.9|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Inguinal, Hyperplasia, Histiocytic | | 1 4.0|
Inguinal, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Inguinal, Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Inguinal, Pigmentation | 3 3 3 | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2| |
| 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10.0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mandibular, Hyperplasia, Lymphoid | | 1 3.0|
Mandibular, Hyperplasia, Plasma Cell | 3 | 2 3.0|
Mandibular, Pigmentation | 3 | 2 3.0|
Mesenteric, Angiectasis | 3 | 2 3.0|
Mesenteric, Atrophy | 3 | 1 3.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 3 4 3 3 | 6 3.2|
Mesenteric, Hemorrhage | 2 2 4 2 | 14 2.8|
Mesenteric, Hyperplasia, Plasma Cell | | 1 2.0|
Mesenteric, Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
Mesenteric, Lymphatic, Ectasia | 3 | 2 2.5|
Renal, Hemorrhage | 3 | 1 3.0|
Renal, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Renal, Lymphatic, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | | |
Granulocytic | 3 | 4 2.5|
Hematopoietic Cell Proliferation | | |
Erythrocytic | 3 3 3 3 3 | 10 2.9|
Hyperplasia, Lymphoid | 3 | 3 2.3|
Hyperplasia, Megakaryocyte | | 1 3.0|
Lymphoid Follicle, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M M + + M + + M + + M + + + + + + M M + M M + M +| 32 |
Atrophy | | 1 3.0|
Cyst | X X X | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 3 3 3 X 2 2 2 | 16 2.5|
Acanthosis, Multiple | 3 | 1 3.0|
Edema | 3 | 3 3.0|
Exudate | | 1 2.0|
Fibrosis | 2 | 3 2.3|
Fungus | 4 | 1 4.0|
Inflammation, Chronic | 2 3 2 1 | 7 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Inflammation, Granulomatous | 4 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2| |
| 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10.0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 2 | 4 2.5|
Ulcer | 3 | 3 2.7|
Lymphatic, Angiectasis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dysplasia | | 2 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thalamus, Mineralization | 2 1 3 2 2 2 2 2 2 2 2 3 | 26 2.1|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 4 2 2 2 | 8 2.6|
Inflammation, Chronic | 2 1 2 2 2| 10 2.0|
Inflammation, Suppurative | | 2 2.5|
Alveolar Epithelium, Hyperplasia | 2 1 2 2 | 4 1.8|
Glands, Ectasia | 3 | 1 3.0|
Interstitium, Edema | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2 3| 5 2.2|
Glands, Cyst | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts | 3 4 1 1 1 | 11 2.1|
Congestion | 3 | 1 3.0|
Cyst | X X | 8 |
Glomerulosclerosis | 3 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05049-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 12:38:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2| |
| 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10.0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hydronephrosis | | 1 2.0|
Inflammation, Chronic | 3 1 2 4 2 1 2 1 1 3 1 1 3 2 1 2| 27 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Inflammation, Suppurative | 3 | 2 2.5|
Metaplasia, Osseous | 2 2 | 2 2.0|
Renal Tubule, Atrophy | 2 2 | 4 2.3|
Renal Tubule, Mineralization | 1 1 | 3 1.0|
Renal Tubule, Regeneration | 3 2 4 2 1 1 2 1 1 1 3 2 1 | 24 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + M + + + + + + + + + + + A| 48 |
Edema | | 1 3.0|
Inflammation, Chronic | 3 | 4 2.5|
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | 1 | 1 1.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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