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TDMS Study 05049-02 Pathology Tables

NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97
Route: GAVAGE                                                                                                     Time: 12:38:06




       Facility:  Southern Research Institute

       Chemical CAS #:  62-73-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Necrosis                             |                               2                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  +  +  M  A  +  +  +  +  +  +  M  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Hyperplasia, Lymphoid         |          3                                         3                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duodenum, Hyperplasia, Re Cell       |                      3                                                   |             
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |             
           Mononuclear Cell                |                                                                3         |             
      Mucosa, Ileum, Dysplasia             |          3                                                               |             
      Submucosa, Ileum, Infiltration       |                                                                          |             
          Cellular, Plasma Cell            |          2                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      3           2                    3        4  3      |             
      Inflammation, Chronic                |    2     3              2              2  1  2  1  2     2  1        3   |             
      Inflammation, Chronic Active         |       2                                                                 2|             
      Bile Duct, Cyst                      |                                                                          |             
      Hepatocyte, Cytoplasmic Alteration   |                                                                          |             
      Hepatocyte, Karyomegaly              |                                                                          |             
      Hepatocyte, Necrosis                 |       1     2                                                            |             
      Hepatocyte, Vacuolization Cytoplasmic|       2                                   2                              |             
      Kupffer Cell, Hyperplasia            |             3                                                            |             
      Kupffer Cell, Pigmentation           |             2                                         3                  |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                +              +        +     +     +   |             
      Inflammation, Chronic                | 2                                                                        |             
      Inflammation, Suppurative            | 2                                                              3         |             
      Artery, Hypertrophy                  |                                                          3               |             
      Artery, Inflammation, Chronic        |                                                 3        4               |             
      Fat, Necrosis, Focal                 |                                                                      4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                4         |             
      Cytoplasmic Alteration               |                                        2                                 |             
      Hyperplasia, Focal                   |       2                                                                  |             
      Infarct                              |       2                                                                  |             
      Inflammation, Chronic                |                            2        2                          4         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          2              2                 2                 2     3      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Cyst                    |       X                                                                  |             
      Forestomach, Diverticulum            |          X                                                               |             
      Forestomach, Erosion                 |                                           3                              |             
      Forestomach, Hyperplasia, Focal      |                                  1        2                       2      |             
      Forestomach, Inflammation, Acute     |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
      Glandular, Edema                     |                                                                          |             
      Glandular, Erosion                   |                                                                          |             
      Glandular, Inflammation, Chronic     |             2                                                            |             
      Glandular, Inflammation, Suppurative |                                                                3         |             
      Glandular, Mineralization            |             2                                            2           2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                          +               |             
      Inflammation, Chronic, Multiple      |                                                          3               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                          3               |             
      Coronary Artery, Media, Hypertrophy  |                                                          4               |             
      Myocardium, Angiectasis              |                         2                                                |             
      Myocardium, Fibrosis                 |       1                                                  2               |             
      Myocardium, Inflammation, Chronic    | 2                                                              2         |             
      Myocardium, Inflammation, Suppurative|                                                       4                  |             
      Pericardium, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                       2        3         |             
      Cortex, Cyst                         |                         X                                                |             
      Cortex, Degeneration, Fatty          |                                           3                              |             
      Cortex, Developmental Malformation   |                                                                   X      |             
      Cortex, Hyperplasia, Focal           |                                                                          |             
      Medulla, Vacuolization Cytoplasmic   |                                                                          |             
      Spindle Cell, Hyperplasia            |    3  2  3  2     3  2  2  2     3  3  2  2  2  3  3  3  3  3  3  3  3  3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  A  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                                   X                                 |             
      Ectopic Thymus                       |                                                             X            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      3   |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    2     3  2                                2  3                    3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       3                             2                                    |             
      Inflammation, Suppurative            |                                                                          |             
      Follicle, Dilatation                 |             4           2              3                                 |             
      Follicular Cell, Hyperplasia         |       3                 2              2        2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +              +                                          |             
      Foreign Body                         |                4              4                                          |             
      Inflammation, Suppurative            |                4              4                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |    X        X                    X     X              X  X           X  X|             
      Hemorrhage                           |             2                                         4                  |             
      Inflammation, Chronic                |                                                                      4   |             
      Inflammation, Suppurative            | 4                                            4     4           4     4   |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         3                                                |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  | 3  3  3  4  4     4  4  4  3     3     3  3  3  3  3  3  2  2  2  3  3  4|             
      Hyperplasia, Cystic, Multiple        |                                     4                                    |             
      Hyperplasia, Glandular               |                         3                                                |             
      Inflammation, Chronic                |                                                 3                        |             
      Inflammation, Suppurative            |                                                 3  3           4     3   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                A                                      +                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                 3                             3  3  2        4  4  3   |             
      Hyperplasia, Reticulum Cell          |          2                                                               |             
      Myelofibrosis                        |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +|             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                   2                                                      |             
      Inguinal, Hyperplasia, Lymphoid      |          3                                                               |             
      Lymphatic, Mandibular, Ectasia       |                                                 3                        |             
      Mandibular, Hyperplasia, Lymphoid    |          2                                                               |             
      Mandibular, Hyperplasia, Plasma Cell |    3                    3                                               3|             
      Mediastinal, Angiectasis             | 3                                                                        |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mesenteric, Angiectasis              |                            3                                             |             
      Mesenteric, Atrophy                  |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                4         |             
      Mesenteric, Hemorrhage               |          4  2              2           2                                 |             
      Mesenteric, Hyperplasia, Histiocytic |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |          3                                                               |             
      Mesenteric, Hyperplasia, Plasma Cell |          3                                                               |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Polymorphonuclear               |                                                                          |             
      Mesenteric, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
      Mesenteric, Lymphatic, Ectasia       |          4                                                               |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                   2                             3              3         |             
      Renal, Inflammation, Suppurative     |                                                                4         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     | 3           3                                      2           4  3      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                      2  2  3     3                    3                  |             
      Hyperplasia, Lymphoid                |          2              2                                            3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                         X        X                                       |             
      Hyperplasia, Lymphoid                |          3                                                               |             
      Necrosis, Diffuse                    |                               3                                          |             
      Medulla, Hyperplasia, Mononuclear    |                                                                          |             
          Cell                             |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                         3  2        2  2                 3  2           3|             
      Hyperplasia, Lobular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |          2  2           2  2     2                       3           3   |             
      Necrosis                             |                                           2                              |             
      Cranium, Hyperostosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                    +                       +               |             
      Inflammation, Chronic                |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Hemorrhage               |                                                                          |             
      Cerebellum, Infiltration Cellular,   |                                                                          |             
           Lymphocyte                      |    2     2                                                               |             
      Cerebrum, Hemorrhage                 |                                                                          |             
      Cerebrum, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |    2                                                                     |             
      Thalamus, Hemorrhage                 |                                                                          |             
      Thalamus, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |    2                                                                     |             
      Thalamus, Mineralization             | 2  1              2        2     2  2     1  2  3  3  2  2  2  2  3  3  2|             
      Vein, Adventitia, Infiltration       |                                                                          |             
          Cellular, Lymphocyte             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                   3                                                      |             
      Inflammation, Chronic                |    3  2  3  3     3  2  2  2     3  2  3  2  2     2     2        2  2  2|             
      Inflammation, Suppurative            | 3                                         2                              |             
      Interstitium, Edema                  |                                                                          |             
      Pleura, Inflammation, Suppurative    | 2              3              3                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                      3                             2           2         |             
      Inflammation, Chronic Active         |    3                                3     3                              |             
      Inflammation, Suppurative            |    4  2     1        3  3        3  2  3  4  3  2  2     3        1  4  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   4                                                      |             
      Glands, Inflammation, Suppurative    |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                             +            |             
      Infiltration Cellular, Lymphocyte    |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts                                |    1  1                    2        1                 2     2        1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Glomerulosclerosis                   |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |    3  2  3  2           2        2  2  2  2  2  3     2  2     4  3     2|             
      Inflammation, Suppurative            |                                                                4         |             
      Metaplasia, Osseous                  |                            2                                             |             
      Artery, Inflammation, Chronic        |                                                          4               |             
      Artery, Media, Hypertrophy           |                                                          4               |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Degeneration           |                                                                3         |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Regeneration           |                            2              1     3                    2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  I|             
      Edema                                |                                  3                                       |             
      Inflammation, Chronic                |    2  2  3  2           2        3  3  3           2              3      |             
      Inflammation, Suppurative            |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Diverticulum                         |                                                          X               |      1     |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  M  A  +  M  +  M  +  +  +  +  +  M  A  +  I  +  +  M  +  M  I|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cecum, Hyperplasia, Lymphoid         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  M  +  +  +  +|  46        |
      Duodenum, Hyperplasia, Re Cell       |                                                                          |      1  3.0|
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |            |
           Mononuclear Cell                |                                                                          |      1  3.0|
      Mucosa, Ileum, Dysplasia             |                                                                          |      1  3.0|
      Submucosa, Ileum, Infiltration       |                                                                          |            |
          Cellular, Plasma Cell            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |             3           3           2                                    |      8  2.9|
      Inflammation, Chronic                |       2  2                    2        1                                 |     15  1.9|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Bile Duct, Cyst                      |                         X                                                |      1     |
      Hepatocyte, Cytoplasmic Alteration   |                                           2                              |      1  2.0|
      Hepatocyte, Karyomegaly              |                                                          2               |      1  2.0|
      Hepatocyte, Necrosis                 |    3                                            3     3                  |      5  2.4|
      Hepatocyte, Vacuolization Cytoplasmic|                      3                                               3   |      4  2.5|
      Kupffer Cell, Hyperplasia            |             4           4                                                |      3  3.7|
      Kupffer Cell, Pigmentation           |                                                                   3      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +     +     +        +                 +     +     +         |  13        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |             4     3     3                                                |      5  3.0|
      Artery, Hypertrophy                  |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |                                                                          |      2  3.5|
      Fat, Necrosis, Focal                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |                                                                   2      |      2  3.0|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                       2                  |      4  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Cyst                    |                                                                          |      1     |
      Forestomach, Diverticulum            |                                                                          |      1     |
      Forestomach, Erosion                 |                                                                          |      1  3.0|
      Forestomach, Hyperplasia, Focal      |          1                          2                 2                  |      6  1.7|
      Forestomach, Inflammation, Acute     |                                                                          |      1  2.0|
      Forestomach, Inflammation, Chronic   |                                     2                                    |      1  2.0|
      Glandular, Edema                     |                         3                                                |      1  3.0|
      Glandular, Erosion                   |                                                    3                     |      1  3.0|
      Glandular, Inflammation, Chronic     |                                                                          |      1  2.0|
      Glandular, Inflammation, Suppurative |                         3              2                                 |      3  2.7|
      Glandular, Mineralization            |                                     2              2                     |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation, Chronic, Multiple      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                2         |      2  2.5|
      Coronary Artery, Media, Hypertrophy  |                                                                          |      1  4.0|
      Myocardium, Angiectasis              |                                                                          |      1  2.0|
      Myocardium, Fibrosis                 |                                                                   1      |      3  1.3|
      Myocardium, Inflammation, Chronic    |                                                                          |      2  2.0|
      Myocardium, Inflammation, Suppurative|                   2     2                                                |      3  2.7|
      Pericardium, Inflammation,           |                                                                          |            |
          Suppurative                      | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Cortex, Cyst                         |                                                                          |      1     |
      Cortex, Degeneration, Fatty          |                               3           2                          2   |      4  2.5|
      Cortex, Developmental Malformation   |                                                                          |      1     |
      Cortex, Hyperplasia, Focal           |                                           3                              |      1  3.0|
      Medulla, Vacuolization Cytoplasmic   |                                                    2                     |      1  2.0|
      Spindle Cell, Hyperplasia            |       3  2  3     3  2  3  2     3  3  3  2        2  2  2     3  3  2  2|     40  2.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
      Cyst                                 |             X                                                            |      3     |
      Ectopic Thymus                       |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  45        |
      Angiectasis                          |                                                                          |      1  3.0|
      Pars Distalis, Angiectasis           |       1                 1                                                |      2  1.0|
      Pars Distalis, Cyst                  |                                                                   X      |      1     |
      Pars Distalis, Hyperplasia           |       1                 2        3     2              1           1     1|     13  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                            1                                             |      1  1.0|
      Follicle, Dilatation                 |                            2     3                                3      |      6  2.8|
      Follicular Cell, Hyperplasia         |                         2                                                |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +              +                             +           +  +            |   7        |
      Foreign Body                         | 4              4                             4              3            |      6  3.8|
      Inflammation, Suppurative            | 4              4                             4              3            |      6  3.8|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |       X  X        X        X        X                    X     X  X  X  X|     18     |
      Hemorrhage                           |                                                          3               |      3  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |             4     4                                                      |      7  4.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hydrometra                           | 3                                                                        |      1  3.0|
      Hyperplasia, Cystic                  |    3  4  4  2     3  3  3  3  3  2  3  2  2           3        3  2  3  4|     40  3.0|
      Hyperplasia, Cystic, Multiple        |                                                                          |      1  4.0|
      Hyperplasia, Glandular               |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                        3                                 |      2  3.0|
      Inflammation, Suppurative            | 2           4     2                 3                                    |      8  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |       +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      2  3        3                 3  3           4      |     14  3.1|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
      Myelofibrosis                        |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Iliac, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                   3      |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         |                               2                                          |      1  2.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  3.0|
      Lymphatic, Mandibular, Ectasia       |                                                                          |      1  3.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |      3  3.0|
      Mediastinal, Angiectasis             |                                                                          |      1  3.0|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                         3                                                |      1  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                         3                                                |      1  3.0|
      Mesenteric, Angiectasis              |                                                                          |      1  3.0|
      Mesenteric, Atrophy                  |                                                                          |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                     3                             3      |      3  3.3|
      Mesenteric, Hemorrhage               |                               3     2                 3                  |      7  2.6|
      Mesenteric, Hyperplasia, Histiocytic |          3                                                               |      1  3.0|
      Mesenteric, Hyperplasia, Lymphoid    |             3                                                            |      2  3.0|
      Mesenteric, Hyperplasia, Plasma Cell |                                                                          |      1  3.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Polymorphonuclear               |                                                       3                  |      1  3.0|
      Mesenteric, Inflammation,            |                                                                          |            |
          Granulomatous                    |                   2                                                      |      1  2.0|
      Mesenteric, Lymphatic, Ectasia       |                                                                          |      1  4.0|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                   3      |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                   2                                                      |      1  2.0|
      Renal, Hyperplasia, Plasma Cell      |                   3                                                      |      4  2.8|
      Renal, Inflammation, Suppurative     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |             4           4           3                                    |      8  3.3|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                   2  3                                4           3      |      9  2.8|
      Hyperplasia, Lymphoid                |                                                                      3   |      4  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  I  M  M  M  +  +  +  +  M  +  +|  41        |
      Atrophy                              | 3              4                                                         |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      2     |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Necrosis, Diffuse                    |                                                             3            |      2  3.0|
      Medulla, Hyperplasia, Mononuclear    |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Hyperplasia, Cystic                  |                         4  3  2           3           2                  |     12  2.6|
      Hyperplasia, Lobular                 |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                   2      |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                   1      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |       3  3           2  2  2     2  3  2                                 |     15  2.3|
      Necrosis                             |                                                                          |      1  2.0|
      Cranium, Hyperostosis                |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                                    |   4        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebellum, Hemorrhage               |                                                 3                        |      1  3.0|
      Cerebellum, Infiltration Cellular,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  2.0|
      Cerebrum, Hemorrhage                 |                                                 3                        |      1  3.0|
      Cerebrum, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Thalamus, Hemorrhage                 |                                                 3                        |      1  3.0|
      Thalamus, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Thalamus, Mineralization             |    2     3           2  3  3                    2              2         |     24  2.2|
      Vein, Adventitia, Infiltration       |                                                                          |            |
          Cellular, Lymphocyte             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | M  M  +  +  +  M  M  I  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +|  41        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                       4                  |      1  4.0|
      Infiltration Cellular, Histiocyte    |       3                                                                  |      2  3.0|
      Inflammation, Chronic                |       3  2        2        2           2                                2|     24  2.3|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Interstitium, Edema                  | 3                                                  2     2               |      3  2.3|
      Pleura, Inflammation, Suppurative    | 4              4  3                          3              3            |      8  3.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +|  43        |
      Foreign Body                         |                                                    3                     |      1  3.0|
      Inflammation, Chronic                |                                  3                                       |      4  2.5|
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
      Inflammation, Suppurative            |          2  2        2        2  3  3  4           4              3     2|     26  2.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                       3                  |      2  3.5|
      Glands, Inflammation, Suppurative    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                     +  +                                 |   3        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Casts                                |                   2  2        1                    2     3               |     12  1.7|
      Cyst                                 |       X                                                                  |      1     |
      Glomerulosclerosis                   |                                                          2               |      1  2.0|
      Infarct                              |                   3                                                      |      1  3.0|
      Inflammation, Chronic                |       3  2  2     2  3  2  2  1     3  2              2           2  1  2|     30  2.2|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Metaplasia, Osseous                  |                                  2                                       |      2  2.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
      Artery, Media, Hypertrophy           |                                                                          |      1  4.0|
      Renal Tubule, Atrophy                |                            2        2                             2      |      3  2.0|
      Renal Tubule, Degeneration           |                                                                          |      1  3.0|
      Renal Tubule, Dilatation             |                               2                                          |      1  2.0|
      Renal Tubule, Regeneration           |                      2        1                          3        2      |      8  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +|  44        |
      Edema                                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |          2                 3  3     3  3           2  3        3     3   |     19  2.6|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    40.0                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Mucosa, Necrosis              |                               1                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duodenum, Amyloid Deposition         |                                                                          |             
      Ileum, Amyloid Deposition            |                                                          4               |             
      Jejunum, Amyloid Deposition          |                                                          2               |             
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |             
           Lymphoid                        |                                                          2               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                                      X   |             
      Fibrosis                             | 3                                                                        |             
      Hematopoietic Cell Proliferation     |       2  3        3                                                      |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                  3                                       |             
      Inflammation, Chronic                |       3                    2                    3  2     2  3  3     2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Hepatocyte, Cytoplasmic Alteration   |                      3                                                   |             
      Hepatocyte, Karyomegaly              |                   3                                                      |             
      Hepatocyte, Necrosis                 | 4        3  2                       3                                3   |             
      Hepatocyte, Vacuolization Cytoplasmic|                               3                 2     2              2   |             
      Kupffer Cell, Hyperplasia            |       3  3  4                                                  3         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +     +                                                  +     +   |             
      Inflammation, Suppurative            |             4                                                            |             
      Fat, Inflammation, Chronic Active    |                                                                      3   |             
      Fat, Mineralization                  |    2                                                           3     3   |             
      Fat, Necrosis, Focal                 |    3                                                           3     3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cytoplasmic Alteration               |          4                                                               |             
      Inflammation, Chronic                |                            2                                             |             
      Acinus, Vacuolization Cytoplasmic    |                               3                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          2                                               1               |             
      Inflammation, Suppurative            |          2                                                               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Diverticulum            |                                                                          |             
      Forestomach, Foreign Body            |                                                                          |             
      Forestomach, Hyperplasia, Focal      |                                           2              2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    40.0                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                        2                                 |             
      Forestomach, Inflammation,           |                                                                          |             
          Suppurative                      |       4                                                                  |             
      Glandular, Atrophy                   |             3                                                            |             
      Glandular, Inflammation, Suppurative |                                                                          |             
      Glandular, Metaplasia, Squamous      |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                         +                                                |             
      Aorta, Mineralization                |                         2                                                |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endocardium, Inflammation, Chronic   |                                                                          |             
          Active                           |          3                                                               |             
      Myocardium, Inflammation, Chronic    | 2                                                                        |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
          Active                           |          3                                                               |             
      Myocardium, Mineralization           |                      4                                                   |             
      Ventricle, Embolus Bacterial         |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Degeneration, Fatty          |                                                                          |             
      Cortex, Necrosis                     |             2                                                            |             
      Medulla, Angiectasis                 |                                                                          |             
      Spindle Cell, Hyperplasia            | 3  3  3  3  3     2  2  3  2  3  2  2  3  3     3  3  3  2  3  3  3  2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               3  3                                   2   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3              2                                2                  |             
      Pars Distalis, Angiectasis           |          2                                                               |             
      Pars Distalis, Cyst                  |                                                             X            |             
      Pars Distalis, Hyperplasia           |       3  3                    2  3  3           1              2     1   |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                          2               |             
      Follicle, Dilatation                 |                                                             3            |             
      Follicle, Hyperplasia                |                                                                          |             
      Follicular Cell, Hyperplasia         |       3                                                              2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    40.0                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis                          |       3                          2                                       |             
      Cyst                                 |    X  X  X                                X     X  X           X        X|             
      Hemorrhage                           | 3        3                                                  2           3|             
      Inflammation, Suppurative            |             4     4                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                                                |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  | 3  2  4  2  3     2  4  3  3     2  3  4  4     3  3  3  3  3  4  3  3  3|             
      Hyperplasia, Glandular               |                                  3                                       |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |             4     4                                                      |             
      Endometrium, Vacuolization           |                                                                          |             
          Cytoplasmic                      |                                                                          |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                               +                                          |             
      Hyperplasia, Squamous                |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2           4                                                      |             
      Hyperplasia, Reticulum Cell          |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |             
      Mandibular, Necrosis, Diffuse        |                               2                                          |             
      Mandibular, Pigmentation             |                               3           3                 3            |             
      Mediastinal, Hyperplasia, Histiocytic|             4                                                            |             
      Mesenteric, Angiectasis              |                   3                                                      |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                   2                                                      |             
      Mesenteric, Hemorrhage               |             2                          2                                 |             
      Mesenteric, Hyperplasia, Histiocytic |             3                          3                                 |             
      Pancreatic, Hyperplasia, Lymphoid    |             4                                                        4   |             
      Pancreatic, Necrosis                 |             4                                                            |             
      Renal, Hyperplasia, Lymphoid         |             3     2                                                      |             
      Renal, Hyperplasia, Plasma Cell      |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             M                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |       2     3                                                            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    40.0                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Erythrocytic                     | 4  2     3        4                 3                                    |             
      Hyperplasia, Lymphoid                |          3                       2                       2               |             
      Red Pulp, Pigmentation               |                               3                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3           4                                                   |             
      Cyst                                 |          X                                X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    3  2  3        3                    1                             1   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Exudate                              |                                                                          |             
      Inflammation, Suppurative            |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |       2                    3     2  2     3              X               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                                   |             
      Mineralization                       |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Degeneration, Multifocal | 3                                                                        |             
      Cerebellum, Hemorrhage               | 3                                                                        |             
      Hippocampus, Necrosis                |          2                                                               |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                      2   |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |             3                                                            |             
      Thalamus, Degeneration               |          2                                                               |             
      Thalamus, Hemorrhage                 |          3                                                               |             
      Thalamus, Mineralization             |    3        1                       3           1  2  2  3  1     2  2  1|             
      Ventricle, Hydrocephalus             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                1         |             
      Inflammation, Chronic                |    2                       2           2        3        2  3  2        2|             
      Inflammation, Suppurative            |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    40.0                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Artery, Mineralization               |                         2                                                |             
      Interstitium, Edema                  |                   2                       3                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                               3                             3            |             
      Fungus                               |                                                       3                  |             
      Hemorrhage                           |                                                                      2   |             
      Inflammation, Suppurative            | 2     3  4  3     3     4     3  2  4  4        3  4  3  3  4  3  4  3  4|             
      Submucosa, Hyperplasia, Lymphoid     |                                        3                       3         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Middle Ear, Inflammation, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts                                |       1  3  1           2        1                                       |             
      Inflammation, Chronic                |          2        2     2  2     3     2  3                 2     2  2  2|             
      Inflammation, Suppurative            |          1                                                               |             
      Metaplasia, Osseous                  |                                                                          |             
      Renal Tubule, Atrophy                |       2                                   2                              |             
      Renal Tubule, Regeneration           |          3           2                    1        1                     |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                          +               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2  2                 2           3           2  3  2  3        2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    40.0                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |                                           X                              |      1     |
      Infiltration Cellular, Lymphocyte    |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cecum, Mucosa, Necrosis              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Duodenum, Amyloid Deposition         |                   2                                                      |      1  2.0|
      Ileum, Amyloid Deposition            |                   4     2                                                |      3  3.3|
      Jejunum, Amyloid Deposition          |                   2                                                      |      2  2.0|
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |            |
           Lymphoid                        |       4                                4                                 |      3  3.3|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       4                                                                  |      1  4.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.7|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
      Inflammation, Chronic                |    2  3                    2        3                       2            |     13  2.5|
      Inflammation, Chronic Active         | 1                                                                        |      1  1.0|
      Bile Duct, Cyst                      |                X                                                         |      1     |
      Hepatocyte, Cytoplasmic Alteration   |                                                                          |      1  3.0|
      Hepatocyte, Karyomegaly              |                                                                          |      1  3.0|
      Hepatocyte, Necrosis                 |                                                                          |      5  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      4  2.3|
      Kupffer Cell, Hyperplasia            |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                   +                     |   7        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Fat, Inflammation, Chronic Active    |                                                                          |      1  3.0|
      Fat, Mineralization                  |                                                                          |      3  2.7|
      Fat, Necrosis, Focal                 |                2                                                         |      4  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |       1                                                                  |      1  1.0|
      Cytoplasmic Alteration               |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                2                       1     2  1              2         |      7  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    40.0                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Diverticulum            |                                                             X            |      1     |
      Forestomach, Foreign Body            |                                     2                                    |      1  2.0|
      Forestomach, Hyperplasia, Focal      |                                     3              2     2               |      5  2.2|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                     2                                    |      2  2.0|
      Forestomach, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                          2               |      2  3.0|
      Glandular, Atrophy                   |                                                                          |      1  3.0|
      Glandular, Inflammation, Suppurative |             2                                                            |      1  2.0|
      Glandular, Metaplasia, Squamous      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endocardium, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Myocardium, Inflammation, Chronic    |                                                                          |      1  2.0|
      Myocardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Myocardium, Mineralization           |                                                                          |      1  4.0|
      Ventricle, Embolus Bacterial         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cortex, Degeneration, Fatty          |                   2        2                                             |      2  2.0|
      Cortex, Necrosis                     |                                                                          |      1  2.0|
      Medulla, Angiectasis                 |             4                                                            |      1  4.0|
      Spindle Cell, Hyperplasia            | 2  3  3  3  2  3  3  2  2  2  2  2  2  2  3  2  3  2  2  2  3  2  3  2  3|     48  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                2        2     1        3                                 |      7  2.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +|  44        |
      Angiectasis                          |                      2                 2                          2      |      6  2.2|
      Pars Distalis, Angiectasis           |                                                       1                  |      2  1.5|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |       2  2                 3           1                       2         |     13  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    40.0                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Intermedia, Hyperplasia         |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                                                          2               |      2  2.0|
      Follicle, Dilatation                 |       4  3                       3  3  3  3                 3            |      8  3.1|
      Follicle, Hyperplasia                |       2                                                                  |      1  2.0|
      Follicular Cell, Hyperplasia         |    2     2                 3                          2                  |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |             2                                                            |      1  2.0|
      Angiectasis                          |                                                                          |      2  2.5|
      Cyst                                 | X           X  X  X  X                 X  X              X     X  X  X   |     19     |
      Hemorrhage                           |             4     3                                         2            |      7  2.9|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hydrometra                           |    3                                                                     |      1  3.0|
      Hyperplasia, Cystic                  | 4  3  3  3  3  2  2  3  3  3     2  3  3  3  2  3  4  3  2     2  3  3  4|     45  3.0|
      Hyperplasia, Glandular               |                                  2                                       |      2  2.5|
      Inflammation, Chronic                |                                  3                                       |      1  3.0|
      Inflammation, Suppurative            | 1                                2        2  2           2               |      7  2.4|
      Endometrium, Vacuolization           |                                                                          |            |
          Cytoplasmic                      |                                                                3         |      1  3.0|
      Mucosa, Metaplasia, Squamous         |                            2     2                                       |      2  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  3.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mandibular, Hyperplasia, Lymphoid    |       3     3                    3                          4            |      4  3.3|
      Mandibular, Hyperplasia, Plasma Cell |                                                             4            |      1  4.0|
      Mandibular, Necrosis, Diffuse        |                                                                          |      1  2.0|
      Mandibular, Pigmentation             |                                                                          |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    40.0                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  4.0|
      Mesenteric, Angiectasis              |                                                                          |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Mesenteric, Hemorrhage               |                                           2                       2      |      4  2.0|
      Mesenteric, Hyperplasia, Histiocytic |                                                                          |      2  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      2  4.0|
      Pancreatic, Necrosis                 |                                                                          |      1  4.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      2  2.5|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |             3                                4                           |      7  3.3|
      Hyperplasia, Lymphoid                |       3  3  3                    3                                       |      7  2.7|
      Red Pulp, Pigmentation               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|  45        |
      Atrophy                              |                                                                          |      2  3.5|
      Cyst                                 | X                                                                        |      3     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Cystic                  |                1        2     3                                          |      9  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |          1           2  1                                                |      3  1.3|
      Exudate                              |          1                                                               |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |       3        3  2        3           2           3              3  3   |     14  2.6|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebellum, Degeneration, Multifocal |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    40.0                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cerebellum, Hemorrhage               |                                                                          |      1  3.0|
      Hippocampus, Necrosis                |                                                                          |      1  2.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |          2                                                               |      2  2.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                                                                          |      1  3.0|
      Thalamus, Degeneration               |                                                                          |      1  2.0|
      Thalamus, Hemorrhage                 |                                                                          |      1  3.0|
      Thalamus, Mineralization             | 2                                   2              2  1  2           2  1|     18  1.8|
      Ventricle, Hydrocephalus             |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  45        |
      Degeneration                         |                            2                                             |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                   2                                                      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomatosis                         |                                           2                              |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                    3                     |      2  2.0|
      Inflammation, Chronic                |    2     2  2     2              2     2  4  2        3        2        2|     19  2.3|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
      Interstitium, Edema                  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Foreign Body                         |                                                                          |      2  3.0|
      Fungus                               |                                                                          |      1  3.0|
      Hemorrhage                           |          3     3                                                         |      3  2.7|
      Inflammation, Suppurative            | 3        3  3  4        3              3           3  3  3  3  3  3  3  3|     33  3.2|
      Submucosa, Hyperplasia, Lymphoid     |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                               +                             +            |   2        |
      Middle Ear, Inflammation, Suppurative|                               2                             4            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Casts                                |                                     1                                   1|      8  1.5|
      Inflammation, Chronic                |    2     2  2                    2  2  2  2  2  1     3  2  2  2     2  2|     26  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    40.0                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                                                          2               |      1  2.0|
      Renal Tubule, Atrophy                |       2     2                          2                                 |      5  2.0|
      Renal Tubule, Regeneration           |             1                    2                                       |      6  1.7|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |    2                                2                       2     2      |     13  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20.0                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Muscularis, Inflammation, Chronic    |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  I  +  +  +  +  +  A  A  +  +  +  +  M  +  +  +  +  M  +|             
      Infiltration Cellular, Lymphocyte    |                                                          2               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Jejunum, Fibrosis                    | 3                                                                        |             
      Jejunum, Inflammation, Suppurative   |                                                                          |             
      Jejunum, Necrosis                    | 3                                                                        |             
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |             
           Lymphoid                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |                                                             2            |             
      Inflammation, Chronic Active         |          2                       2                                       |             
      Inflammation, Suppurative            |                                                                          |             
      Hepatocyte, Karyomegaly              |                                                                      3   |             
      Hepatocyte, Necrosis                 |    2     1                                                           1  1|             
      Hepatocyte, Vacuolization Cytoplasmic|                                     2                       2            |             
      Kupffer Cell, Hyperplasia            |    3                                                                 2   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +                                                        +            |             
      Inflammation, Chronic                |                                                             3            |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |    4                                                                     |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      2                                      2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             2     1  2  2                                            2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Hyperplasia, Focal      |                                                 3                    1   |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |             3                                                            |             
      Forestomach, Mineralization          |                         2                                                |             
      Forestomach, Mucosa, Hyperplasia,    |                                                                          |             
           Focal                           |             3                                                            |             
      Glandular, Cyst                      |                                                                          |             
      Glandular, Hemorrhage                |                                                                          |             
      Glandular, Metaplasia, Squamous      |                                                                          |             
      Glandular, Mineralization            |                         2                                                |             
      Glandular, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20.0                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multiple                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           | X                                                                        |             
      Artery, Mineralization               |                                                                          |             
      Endocardium, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
          Active                           |       2                                                                  |             
      Pericardium, Inflammation, Chronic   |                                                                          |             
          Active                           |                3                                                         |             
      Valve, Inflammation, Suppurative     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Cortex, Degeneration, Fatty          |                                                             2            |             
      Cortex, Developmental Malformation   |                                                                         X|             
      Cortex, Hyperplasia, Focal           |                                                       2                  |             
      Cortex, Necrosis                     |    2                                                                     |             
      Cortex, Vacuolization Cytoplasmic    |                                                          2               |             
      Spindle Cell, Hyperplasia            |    3  2  3  2     3  2  2  2     3  2  2     3  3  3  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
      Cyst                                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      2   |             
      Pars Distalis, Hyperplasia           |                      2                       2           2              2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                             3        2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                         1                                                |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicle, Dilatation                 |    3        3           3  3                       3        2            |             
      Follicular Cell, Hyperplasia         |                      2                          2           3            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +              +                                          |             
      Foreign Body                         |                2              2                                          |             
      Hemorrhage                           |                               4                                          |             
      Inflammation, Chronic Active         |                4                                                         |             
      Inflammation, Suppurative            |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20.0                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Cyst                                 |       X     X  X                       X     X     X                     |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |    3                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                   2                                                      |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  | 3  3  2  3  3     3  3  2  4     3  2     2  2  3  3  3  4  3  3  3  4  3|             
      Inflammation, Suppurative            |    3  2                          1                 2                     |             
      Endometrium, Edema                   |                         2                                                |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                      +                                                   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  2        3                 2                                       |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Inflammation, Suppurative |    2                                                                     |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Mandibular, Hyperplasia, Histiocytic |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |             
      Mandibular, Pigmentation             | 2                                                                        |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
      Mediastinal, Hemorrhage              |    3                                                                     |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |    3                                                                     |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mesenteric, Hemorrhage               |                         3                                                |             
      Mesenteric, Hyperplasia, Histiocytic |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                 2        3               |             
      Mesenteric, Hyperplasia, Plasma Cell |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20.0                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |    2  2                                                                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                  2                 2        2     2      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                           3                          3   |             
      Hyperplasia, Megakaryocyte           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2           3                                                         |             
      Hyperplasia, Lymphoid                |                                                 3                        |             
      Mineralization                       |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                         2                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      2     1                                             |             
      Inflammation, Granulomatous          |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                   2  3     2                       2     2  2        2  3|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                         +               |             
      Inflammation, Chronic Active         |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Hemorrhage               |                                                                          |             
      Cerebrum, Hemorrhage                 |                                                                          |             
      Thalamus, Mineralization             | 1  2  2  1  1     1  2  2        2  1        1  2        1        3  2   |             
      Vein, Adventitia, Infiltration       |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             
      Ventricle, Mineralization            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                              1                           |             
      Infiltration Cellular, Lymphocyte    |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |    4                                                                     |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20.0                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |          2  2        2  2  2     3     2  2     3           2  2     2   |             
      Inflammation, Suppurative            |    4                                                                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Inflammation, Suppurative    |    4                                                                     |             
      Pleura, Inflammation, Chronic        |                                                                          |             
      Pleura, Inflammation, Chronic Active |                3                                                         |             
      Pleura, Inflammation, Suppurative    |                               3                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                        3  3                              |             
      Fungus                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |       2  1        3     4              4  4  3  2  3        3  2     3  3|             
      Mucosa, Atrophy                      |                                                                          |             
      Mucosa, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +     +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts                                |             2     2  1  1  1           1        1     1                  |             
      Cyst                                 |             X                                                            |             
      Glomerulosclerosis                   |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |    3                                                                     |             
      Inflammation, Chronic                |          3  2        1  1              2  2  2  3  2        3  2     2   |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                         3                                2               |             
      Pigmentation                         |             3                                                            |             
      Glomerulus, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Mineralization         |                                                       1                  |             
      Renal Tubule, Regeneration           |    1                                               1                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  M  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  M  +  +  +|             
      Inflammation, Chronic                |             2        3  2        3              2                 2     3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3|            |
                                           | 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    20.0                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Muscularis, Inflammation, Chronic    |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  I  +  +  +  +  +  M  +  +  +|  41        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Jejunum, Fibrosis                    |                                                                          |      1  3.0|
      Jejunum, Inflammation, Suppurative   |                                                       3                  |      1  3.0|
      Jejunum, Necrosis                    |                                                                          |      1  3.0|
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |            |
           Lymphoid                        |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                   3     4                          4  2  4               |      5  3.4|
      Inflammation, Chronic                |       2              2           1     2                                 |      5  1.8|
      Inflammation, Chronic Active         |                            3                                             |      3  2.3|
      Inflammation, Suppurative            |                   4                                                      |      1  4.0|
      Hepatocyte, Karyomegaly              |                                                                          |      1  3.0|
      Hepatocyte, Necrosis                 |                         3  1                             4     2         |      8  1.9|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      2  2.0|
      Kupffer Cell, Hyperplasia            |                                     3                 2  3               |      5  2.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +        +  +                       +  +     +  +         |  10        |
      Inflammation, Chronic                |                         4                                                |      2  3.5|
      Inflammation, Chronic Active         |                                                             3            |      1  3.0|
      Inflammation, Suppurative            |                                                       4                  |      2  4.0|
      Fat, Necrosis, Focal                 |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                          2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |          2                                                               |      6  1.8|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Forestomach, Hyperplasia, Focal      |             3              3                             2              3|      6  2.5|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                            2                                             |      2  2.5|
      Forestomach, Mineralization          |                                                                          |      1  2.0|
      Forestomach, Mucosa, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Glandular, Cyst                      |                                  X                                   X   |      2     |
      Glandular, Hemorrhage                |                                                       3                  |      1  3.0|
      Glandular, Metaplasia, Squamous      |                                        2                                 |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3|            |
                                           | 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    20.0                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Glandular, Mineralization            |                                                                          |      1  2.0|
      Glandular, Necrosis                  |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                   +      |   1        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multiple                         |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           |                                                          X               |      2     |
      Artery, Mineralization               |                                                                   3      |      1  3.0|
      Endocardium, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                    2                     |      1  2.0|
      Myocardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                   2                                                      |      2  2.0|
      Pericardium, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Valve, Inflammation, Suppurative     |                                                          4               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                         3                                   3            |      2  3.0|
      Cortex, Degeneration, Fatty          |                            3                                             |      2  2.5|
      Cortex, Developmental Malformation   |                      X                             X                     |      3     |
      Cortex, Hyperplasia, Focal           |                                                                          |      1  2.0|
      Cortex, Necrosis                     |                                                                          |      1  2.0|
      Cortex, Vacuolization Cytoplasmic    |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            | 3  3  3  2  3     2  2  3  2  2  2  3  2  3        3  3  3  2  3  3  2  2|     43  2.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Cyst                                 |                                                                   X     X|      3     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|  45        |
      Angiectasis                          |                            2                                             |      2  2.0|
      Pars Distalis, Hyperplasia           |                   1  3           1     2  2                       3  2   |     11  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Lymphocyte    |    3                 2                                                   |      4  2.5|
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Ultimobranchial Cyst                 |                                                    X                     |      1     |
      Follicle, Dilatation                 |                                           3                             2|      8  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3|            |
                                           | 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    20.0                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Hyperplasia         |                      2                 3  2                              |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Foreign Body                         |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |    X  X  X  X        X     X              X                    X  X     X|     16     |
      Hemorrhage                           |                                                                         3|      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                   4     4                             4  4  4            |      5  4.0|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                      +   |   1        |
      Inflammation, Chronic                |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                   2      |      1  2.0|
      Hydrometra                           |                               2                                          |      1  2.0|
      Hyperplasia, Cystic                  | 3  3  3  4  3     2  2  2  2     3  2  2  2           3  2     2  4  2  2|     41  2.7|
      Inflammation, Suppurative            |                   3     3  2                       4  3  2  3        2  2|     13  2.5|
      Endometrium, Edema                   |                                                                          |      1  2.0|
      Mucosa, Metaplasia, Squamous         |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   3     4                          4  4  4  3            |     10  3.2|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bronchial, Inflammation, Suppurative |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Plasma Cell      |                         3                                3  3            |      3  3.0|
      Mandibular, Hyperplasia, Histiocytic |                                        2                                 |      1  2.0|
      Mandibular, Hyperplasia, Lymphoid    |                      3                                               2   |      2  2.5|
      Mandibular, Hyperplasia, Plasma Cell |                                                                      2   |      1  2.0|
      Mandibular, Pigmentation             |       3                                                                  |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3|            |
                                           | 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    20.0                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                         3                                                |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                       2                  |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                       2  3               |      2  2.5|
      Mediastinal, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                         4                                3               |      2  3.5|
      Mesenteric, Hemorrhage               |          2           2  2                                               2|      5  2.2|
      Mesenteric, Hyperplasia, Histiocytic |                                     4                                    |      1  4.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                           3                              |      3  2.7|
      Mesenteric, Hyperplasia, Plasma Cell |                                                       3                  |      1  3.0|
      Renal, Hyperplasia, Plasma Cell      |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                  2                                       |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |             3     3     4                             3  3  2            |      8  2.8|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |          2  3                                      4     3               |      8  2.5|
      Hemorrhage                           |                                  3                                       |      1  3.0|
      Hyperplasia, Lymphoid                |                      3                    3                              |      4  3.0|
      Hyperplasia, Megakaryocyte           |                                                                   3      |      1  3.0|
      Necrosis                             |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|  43        |
      Atrophy                              |                      3                                   2               |      4  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Cystic                  |    2     2              2           2                    2        1      |      7  1.9|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                                                          |      2  1.5|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |             3     2        3        2                 2  3              2|     15  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3|            |
                                           | 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    20.0                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebellum, Hemorrhage               |                                                                3         |      1  3.0|
      Cerebrum, Hemorrhage                 |                                                                3         |      1  3.0|
      Thalamus, Mineralization             |       2  1  3           3  3        1  2                 1        2  2   |     25  1.8|
      Vein, Adventitia, Infiltration       |                                                                          |            |
          Cellular, Lymphocyte             |                                                                      2   |      1  2.0|
      Ventricle, Mineralization            |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration                         |                         2                                                |      1  2.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                                                          |      1  4.0|
      Infiltration Cellular, Histiocyte    |    1           2                                                         |      2  1.5|
      Inflammation, Chronic                |    2     2  2        2                                            2      |     17  2.1|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                      3                                                   |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                    3                     |      1  3.0|
      Artery, Inflammation, Suppurative    |                                                                          |      1  4.0|
      Pleura, Inflammation, Chronic        |                                              2                           |      1  2.0|
      Pleura, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Pleura, Inflammation, Suppurative    |                                                 2                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +|  44        |
      Foreign Body                         | 3              3                                                         |      4  3.0|
      Fungus                               |                      3                                                   |      1  3.0|
      Inflammation, Chronic                |                                                                         3|      1  3.0|
      Inflammation, Suppurative            | 3  3  3     2  3     4  3  3        3  4           2     3  2     2  4  3|     29  2.9|
      Mucosa, Atrophy                      |                                                                         3|      1  3.0|
      Mucosa, Necrosis                     |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                                                                  |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3|            |
                                           | 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    20.0                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Casts                                |    1                                2                                    |     10  1.3|
      Cyst                                 |                                     X                                    |      2     |
      Glomerulosclerosis                   |                         2           2                                    |      2  2.0|
      Hydronephrosis                       |                                                          2               |      1  2.0|
      Infarct                              |                                                                      2   |      2  2.5|
      Inflammation, Chronic                | 2  2  2     3        3  2  2     2     2                 2  2        2   |     24  2.1|
      Inflammation, Suppurative            |                   3                                      2               |      2  2.5|
      Metaplasia, Osseous                  |                                        2                                 |      3  2.3|
      Pigmentation                         |                                                                          |      1  3.0|
      Glomerulus, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                          2               |      1  2.0|
      Renal Tubule, Atrophy                |                                                                         2|      1  2.0|
      Renal Tubule, Mineralization         |                                                       2                  |      2  1.5|
      Renal Tubule, Regeneration           |                         3           2                       2            |      5  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Chronic                |          2              2  2                             3  2     2      |     13  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  M  +  M  +  +  +  +  I  +  A  +  +  M  +  +  M  +  +|             
      Concretion                           |                                                    X                     |             
      Hemorrhage                           |                                     3                                    |             
      Inflammation, Suppurative            |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Hyperplasia, Lymphoid         |                                                                   3  3   |             
      Cecum, Mucosa, Fibrosis              |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |             
           Lymphoid                        |          2                                               3     2         |             
      Mucosa, Ileum, Dysplasia             |                                                                         3|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2                                                                  |             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |             3                                                            |             
      Hepatocyte, Anisokaryosis            |                                                                          |             
      Hepatocyte, Cytomegaly               | 2                                                                        |             
      Hepatocyte, Karyomegaly              |                                                                          |             
      Hepatocyte, Necrosis                 |                      4                                   3               |             
      Hepatocyte, Vacuolization Cytoplasmic| 3        2                                   3     3                 2   |             
      Kupffer Cell, Hyperplasia            | 3           3                                                            |             
      Kupffer Cell, Pigmentation           |                                           3                 3            |             
                                            __________________________________________________________________________|             
   Mesentery                               | +           +                 +  +                                       |             
      Inflammation, Suppurative            |                               3                                          |             
      Fat, Necrosis, Focal                 | 3                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Atypia Cellular, Focal               |                                                                          |             
      Inflammation, Chronic                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2     2                             2  2           2  1        3  2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Cyst                    |                                                                          |             
      Forestomach, Hyperplasia             | 3                                2              2           3            |             
      Forestomach, Inflammation, Chronic   |                                                 3           2            |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                  3                                       |             
      Forestomach, Mineralization          |                            2                                             |             
      Forestomach, Ulcer                   | 2                                               3                        |             
      Forestomach, Mucosa, Hyperplasia     |       2                                                                  |             
      Glandular, Cyst                      |                                                                          |             
      Glandular, Dysplasia                 |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Glandular, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
      Glandular, Inflammation, Suppurative |                                                                2         |             
      Glandular, Metaplasia, Squamous      |                                                                          |             
      Glandular, Mineralization            |          2                                                               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +     +        +     +         |             
      Developmental Malformation           |                                                 X        X     X         |             
      Peridontal Tissue, Fibrosis          |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                           3                              |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                              +                           |             
      Inflammation, Chronic Active         |                                              3                           |             
      Aorta, Embolus Bacterial             |                                                                          |             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus Bacterial                    |                                                                          |             
      Thrombosis                           |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Suppurative                      |                                                                          |             
      Coronary Artery, Necrosis, Fibrinoid |                                                                          |             
      Endocardium, Inflammation, Chronic   |                                                                          |             
      Epicardium, Fibrosis                 |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
      Myocardium, Fibrosis                 |                                                                          |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
      Myocardium, Inflammation, Suppurative|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                          X               |             
      Cortex, Hyperplasia, Focal           |                                                                         2|             
      Cortex, Hyperplasia                  |                                                             2            |             
      Cortex, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                       2                  |             
      Medulla, Hyperplasia                 |                                                                          |             
      Spindle Cell, Hyperplasia            |    2  2  2  2           2  2           2        2  2     2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                                                                          |             
      Hyperplasia                          |       2  2  3           2                                   3  3     4  3|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  I  +  +  +  M  M  M  M  M  M  +  +  +  +  +  M  M  +  M  M  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  M  +  M  +  +  +  +  +  M  M  +  M  M  +  +  +  I  +  +  +|             
      Pars Distalis, Cyst                  |                                     X                                X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                         1|             
      Follicle, Crystals                   |                                                                         2|             
      Follicle, Dilatation                 |                                                          2               |             
      Follicular Cell, Hyperplasia         |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                              +                           |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                              4                           |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                      +  M|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +                                +              +         |             
      Ectasia                              | 4  3  3     3                                   4                        |             
      Inflammation, Chronic                |    1     4  3                                   2                        |             
      Inflammation, Chronic Active         |                                                                4         |             
      Inflammation, Suppurative            |          3     3                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   3                                3              2      |             
      Inflammation, Suppurative            |                4              3     3              3                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                A  +     +                          +     +     +         |             
      Amyloid Deposition                   |                         3                                                |             
      Dilatation                           |                                                          3               |             
      Fibrosis                             |                   3     3                                                |             
      Inflammation, Chronic                |                                                    4                     |             
      Inflammation, Suppurative            |                   3                                3                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Mineralization               |             2                                                            |             
      Seminiferous Tubule, Atrophy         |                                                                3         |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   3      |             
      Hyperplasia, Histiocytic             |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                4  3           3                    2  3                 2|             
      Pigmentation                         |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
      Iliac, Hyperplasia, Plasma Cell      |                4                                                         |             
      Inguinal, Fibrosis                   |                                     2                                    |             
      Inguinal, Hyperplasia, Histiocytic   |          4                                                               |             
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |             
      Mesenteric, Atrophy                  |                   4                                                      |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mesenteric, Hemorrhage               |    2  2  2  2           3              2  2                 2     3      |             
      Mesenteric, Hyperplasia, Histiocytic |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                         3|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                      3              2                 3     2           2|             
      Hyperplasia, Lymphoid                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  M  +  +  +  +  M  M  +  M  +  +  +  M  +  M  +  +  M  +  M|             
      Cyst                                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    2                    3     2  2  2                                    |             
      Exudate                              |                               2                                          |             
      Fibrosis                             |                               3                                          |             
      Inflammation, Chronic                |                         3                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multiple                         |                                                             2            |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Proliferation                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                     +  +            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                          3               |             
      Inflammation, Suppurative            |    3                                                        3            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             | 2     3  1           2  1           3     3     2     2     2        1  3|             
      Venule, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  M  M  M  I  I  M  +  +  +  +  +  +  +  M  M  M  +  +  +  +|             
      Inflammation, Chronic                |                                                                2         |             
      Inflammation, Subacute               |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2                                            2           3               |             
      Inflammation, Chronic                |    2  2  2  2                          2  2  3              2  2  2  2   |             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                      X                                                   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Mineralization               |                      2                                                   |             
      Interstitium, Edema                  |                            2  2  2                                       |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |       3                                3           1     2  2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +           +         |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                   M                                                      |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Bacterium                            |                                                                          |             
      Calculus Micro Observation Only      |                               2                                          |             
      Casts                                |                      2                             4        3            |             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                | 2  2        1  3     3                             4     2  3  2  3  2   |             
      Inflammation, Suppurative            |                   4                                2                     |             
      Metaplasia, Osseous                  |                                                                          |             
      Renal Tubule, Atrophy                |                                                    4                     |             
      Renal Tubule, Degeneration           |                               3                                          |             
      Renal Tubule, Dilatation             |                   3           3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Mineralization         |       1                                                                  |             
      Renal Tubule, Regeneration           |       1     1              1           2  1           1  1  3  2  3  1  1|             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                +              +                                          |             
      Angiectasis                          |                               4                                          |             
      Inflammation, Chronic Active         |                3                                                         |             
      Inflammation, Suppurative            |                               2                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             2            |             
      Calculus Gross Observation           |                   X                                                      |             
      Inflammation, Chronic                |                   4                                4                     |             
      Inflammation, Chronic Active         |                3                                                         |             
      Inflammation, Suppurative            |                   3                                                      |             
      Mucosa, Hyperplasia                  |                   3                                4                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Concretion                           |                                              X                           |      2     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cecum, Hyperplasia, Lymphoid         |                                                                          |      2  3.0|
      Cecum, Mucosa, Fibrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |            |
           Lymphoid                        |                                                                          |      3  2.3|
      Mucosa, Ileum, Dysplasia             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Clear Cell Focus                     |       X                             X                                    |      2     |
      Hematopoietic Cell Proliferation     |                      2                 2  4                              |      3  2.7|
      Inflammation, Chronic                |                                                                      3   |      2  3.0|
      Hepatocyte, Anisokaryosis            |          3                                                               |      1  3.0|
      Hepatocyte, Cytomegaly               |                      2                                                   |      2  2.0|
      Hepatocyte, Karyomegaly              |                      3                          3  2                     |      3  2.7|
      Hepatocyte, Necrosis                 |                                              4                           |      3  3.7|
      Hepatocyte, Vacuolization Cytoplasmic|                         1                                         2      |      7  2.3|
      Kupffer Cell, Hyperplasia            |                                                                      3   |      3  3.0|
      Kupffer Cell, Pigmentation           |                                                                      3   |      3  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   5        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            2                                             |      1  2.0|
      Atypia Cellular, Focal               |       2                                                                  |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    2  3     3                          2                                 |     13  2.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Cyst                    |                         X                                                |      1     |
      Forestomach, Hyperplasia             | 1     2     3              3                    3                    2   |     10  2.4|
      Forestomach, Inflammation, Chronic   |                                                                      2   |      3  2.3|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |             2              3                    3                        |      4  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Mineralization          |                                                                          |      1  2.0|
      Forestomach, Ulcer                   |                                                                          |      2  2.5|
      Forestomach, Mucosa, Hyperplasia     |                                                                          |      1  2.0|
      Glandular, Cyst                      |    X                                                                     |      1     |
      Glandular, Dysplasia                 |                                                 3                        |      2  2.5|
      Glandular, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                 2                        |      1  2.0|
      Glandular, Inflammation, Suppurative |       2        2                                                         |      3  2.0|
      Glandular, Metaplasia, Squamous      |                                                                2         |      1  2.0|
      Glandular, Mineralization            |    2                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                            +        +              +                     |   7        |
      Developmental Malformation           |                                                    X                     |      4     |
      Peridontal Tissue, Fibrosis          |                            3                                             |      1  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                     3                                    |      2  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                               +              +                           |   3        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Aorta, Embolus Bacterial             |                               X              X                           |      2     |
      Aorta, Inflammation, Chronic Active  |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Embolus Bacterial                    |                               X                                          |      1     |
      Thrombosis                           |                                                                         4|      1  4.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Suppurative                      |                                              4                           |      1  4.0|
      Coronary Artery, Necrosis, Fibrinoid |                                              4                           |      1  4.0|
      Endocardium, Inflammation, Chronic   |                                                          3               |      1  3.0|
      Epicardium, Fibrosis                 |                                                 2                        |      1  2.0|
      Epicardium, Inflammation, Chronic    |                                                 1                        |      1  1.0|
      Myocardium, Fibrosis                 |          2                                                               |      1  2.0|
      Myocardium, Inflammation, Chronic    |                                                          3               |      1  3.0|
      Myocardium, Inflammation, Suppurative|                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Developmental Malformation           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cortex, Hyperplasia, Focal           |                2                                                         |      2  2.0|
      Cortex, Hyperplasia                  |                                                                          |      1  2.0|
      Cortex, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Medulla, Hyperplasia                 |          3  2                                                            |      2  2.5|
      Spindle Cell, Hyperplasia            |       3     2     2  2  2        2  2  2  2        2  2  2     2         |     27  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia                            |                                                       2                  |      1  2.0|
      Hyperplasia                          | 2                 3              3                 3     2        3     2|     15  2.7|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  M  +  +  M  M  M  I  +  +  +  +  +  +  +  +  M  M|  28        |
      Infiltration Cellular, Lymphocyte    |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  40        |
      Pars Distalis, Cyst                  |                                     X                                    |      3     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|  45        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Follicle, Crystals                   |                                                                          |      1  2.0|
      Follicle, Dilatation                 |                   3                                3           3     3   |      5  2.8|
      Follicular Cell, Hyperplasia         |                                        2           2                 2   |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                             +            |   2        |
      Foreign Body                         |                                                             2            |      1  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                    +                     |   2        |
      Dilatation                           |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +  +     +              +  +           +  +  +  M     +  +  +  +|  20        |
      Ectasia                              |          4  4                    3  3           4  3  3        3  4      |     14  3.4|
      Inflammation, Chronic                |          2  3                    2                             3  2  4   |     10  2.6|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation, Suppurative            |          3        3                             2  4              3  4  4|      9  3.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic                |             2     2                    2                          2      |      7  2.3|
      Inflammation, Suppurative            |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Dilatation                           |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Mineralization               |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         |    3                                                                    1|      3  2.3|
      Seminiferous Tubule, Mineralization  |                      2              2  1                                2|      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia                          |    2                 2                    4                              |      9  2.8|
      Pigmentation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  4.0|
      Inguinal, Fibrosis                   |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Histiocytic   |                            2                                             |      2  3.0|
      Mandibular, Hyperplasia, Plasma Cell |                                           3                              |      1  3.0|
      Mesenteric, Atrophy                  |                                                                          |      1  4.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                   2  2                 3  3                              |      4  2.5|
      Mesenteric, Hemorrhage               |          3        3           3  3  2           2     3           2  3  3|     19  2.5|
      Mesenteric, Hyperplasia, Histiocytic |                                                 3                        |      1  3.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                        4  3                              |      2  3.5|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                      3     2                    3                    2  2|     10  2.4|
      Hyperplasia, Lymphoid                |                            3                                             |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  M  +  +  M|  35        |
      Cyst                                 |                                                    X                 X   |      3     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |    2  3           2                 2  3                       2        3|     12  2.3|
      Exudate                              |                                                                          |      1  2.0|
      Fibrosis                             |                   2                 2                                    |      3  2.3|
      Inflammation, Chronic                |       2                             3  2                                 |      4  2.5|
      Inflammation, Chronic Active         |                                  3                                       |      1  3.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multiple                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                        3                                 |      1  3.0|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                         3|      1  3.0|
      Proliferation                        |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                               +                  |   5        |
      Inflammation, Chronic                |       2                                               2                  |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thalamus, Mineralization             |             1                 1     2        2  2                 2  2  2|     20  2.0|
      Venule, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                                                1         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Subacute               |          3     2                                   2                     |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |                                                                          |      3  2.3|
      Inflammation, Chronic                |    2  1  2  3  3  3  1  2        2     2        2     2  2     2  2  2   |     27  2.1|
      Inflammation, Suppurative            |                                                                2         |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |      1  2.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
      Interstitium, Edema                  |             2                                                            |      4  2.0|
      Pleura, Inflammation, Suppurative    |                                                             3            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
      Inflammation, Chronic                |                                                                3         |      1  3.0|
      Inflammation, Suppurative            |       3  3        3        3        2  3        3     2  2     3        3|     16  2.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +        +  +                    +                              |   6        |
      Inflammation, Chronic                |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                          +               |   1        |
      Inflammation, Chronic                |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |          2                                                               |      1  2.0|
      Bacterium                            |                               3                                          |      1  3.0|
      Calculus Micro Observation Only      |                                                                          |      1  2.0|
      Casts                                |          3                                                              3|      5  3.0|
      Cyst                                 |                   X                                               X     X|      3     |
      Infarct                              |                                                                2         |      1  2.0|
      Inflammation, Chronic                |    3  2  4  2  2  3     2  2  3     1  3        3  2  1  2     2     2  3|     29  2.4|
      Inflammation, Suppurative            |                               3                                          |      3  3.0|
      Metaplasia, Osseous                  | 1                                                                        |      1  1.0|
      Renal Tubule, Atrophy                |          2                                                               |      2  3.0|
      Renal Tubule, Degeneration           |                                                                          |      1  3.0|
      Renal Tubule, Dilatation             |                                                                          |      2  3.0|
      Renal Tubule, Mineralization         |                1                                                         |      2  1.0|
      Renal Tubule, Regeneration           |             1  2        1  1     1  1     2        1  1  1     1  2  1  3|     26  1.4|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
      Angiectasis                          |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Calculus Gross Observation           |                                                                          |      1     |
      Inflammation, Chronic                |    2        2                                                            |      4  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20.0                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  M  M  +  +  M  +  +  +  +  A  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Serosa, Ectopic Tissue        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |             
           Lymphoid                        |                                  2                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |       X                                            X                     |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                      3                                                   |             
      Hyperplasia, Focal                   |                                           2                              |             
      Inflammation, Chronic                | 3                                                        2     2         |             
      Mineralization                       |                                                                          |             
      Hepatocyte, Karyomegaly              |                                                                          |             
      Hepatocyte, Necrosis                 | 3                             3                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|             2                    2              3     2           2     1|             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Vein, Thrombosis                     |                                                                          |             
      Vein, Adventitia, Fibrosis           |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +        +                       +                    +|             
      Fibrosis                             |                                                                         3|             
      Mineralization                       |                                                                         3|             
      Artery, Inflammation, Chronic        |                                                    3                     |             
      Fat, Necrosis, Focal                 |                            4                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  I  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2  2                 2                       2                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Hyperplasia             |                         3                 3                       2      |             
      Forestomach, Inflammation, Chronic   |                                           2                              |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Glandular, Cyst                      |    X                                                                     |             
      Glandular, Mineralization            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                     +        +      |             
      Developmental Malformation           |    X                                                     X               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
      Inflammation, Chronic Active         |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20.0                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |    X                                                  X                  |             
      Cortex, Atrophy                      |                                                                          |             
      Cortex, Hyperplasia, Focal           |                                                                          |             
      Medulla, Hyperplasia                 |                                                                          |             
      Spindle Cell, Hyperplasia            |    2  2  2                       2  2  2              2  2        2     2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  4     3        3     2                             3               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Crystals                             |                                        3                                 |             
      Cyst                                 |                                        X                                 |             
      Infiltration Cellular, Lymphocyte    |          2                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |          2                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Follicle, Dilatation                 |                      2                          4                        |             
      Follicular Cell, Hyperplasia         |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +  +     +              +  +                    +               |             
      Ectasia                              |             3                    2  2                    3               |             
      Inflammation, Chronic                |             2                    3  3                    3               |             
      Inflammation, Suppurative            |          3        3                                      3               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +                                      +                       +|             
      Dilatation                           |                                                                          |             
      Fibrosis                             |                                                 3                       3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20.0                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                         2|             
      Inflammation, Chronic Active         |                                                 3                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                                          |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          4           4                                      4            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Histiocytic   |                                                                      3   |             
      Inguinal, Hyperplasia, Plasma Cell   |                      3                                                   |             
      Inguinal, Pigmentation               |             2                                               3            |             
      Lymphatic, Mandibular, Ectasia       |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mandibular, Hyperplasia, Plasma Cell |    3                       3                                             |             
      Mesenteric, Angiectasis              |             4                                                            |             
      Mesenteric, Atrophy                  |                                                                          |             
      Mesenteric, Congestion               | 3                                                                        |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |    2                             2                 3                     |             
      Mesenteric, Hemorrhage               |    2  2     4  3                 2                                3      |             
      Mesenteric, Hyperplasia, Histiocytic |          3                                                               |             
      Mesenteric, Hyperplasia, Lymphoid    | 3                                                                        |             
      Mesenteric, Hyperplasia, Plasma Cell |                      3                                                   |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Mast Cell                       |                                                                   2      |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Megakaryocyte                   | 3                                                                        |             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |          3        4  4                                                   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     | 3                                                  3  2        3         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Necrosis, Focal                      |                         4                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  I  +  M  M  +  +  M  +  +  +  +  +  +  M  M  +  +  +  M  M  +  +|             
      Cyst                                 |       X     X                       X                 X                 X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20.0                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Acanthosis                           |    1              2                                3           3  3      |             
      Edema                                |                                                                          |             
      Erosion                              |                                                             3  3         |             
      Exudate                              |                                                                          |             
      Fibrosis                             |                      4                                                   |             
      Foreign Body                         |                            3                                             |             
      Fungus                               |                                                                          |             
      Hyperkeratosis                       |                2                                                         |             
      Inflammation, Chronic                |                                                                3  2      |             
      Inflammation, Chronic Active         |                      4                                                   |             
      Inflammation, Granulomatous          |                            3                                             |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                   2  4                                                   |             
      Sebaceous Gland, Hyperplasia         |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                          2               |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Vacuolization Cytoplasmic  |                                                                          |             
      Hippocampus, Infiltration Cellular,  |                                                                          |             
           Lymphocyte                      |                      1                                                   |             
      Thalamus, Mineralization             |    2                 2  2                 2           2  3     2     2  1|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Degeneration                         |                                                                          |             
      Inflammation, Chronic                |                                                    4                     |             
      Inflammation, Subacute               |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                3         |             
      Infiltration Cellular, Eosinophil    |                                                                          |             
      Infiltration Cellular, Histiocyte    |    3                                   3                                 |             
      Inflammation, Chronic                |       2  2  2                    2                       2           2   |             
      Inflammation, Suppurative            |       2  2                                            2     2        2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20.0                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                               X                                          |             
      Bronchus, Foreign Body               |                                                                          |             
      Capillary, Infiltration Cellular,    |                                                                          |             
           Polymorphonuclear               |                                                                          |             
      Interstitium, Edema                  |                                              2     3                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Fungus                               |                                           3                              |             
      Inflammation, Suppurative            |    3  1                 3           2  3  3                              |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Submucosa, Cyst                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
      Cornea, Hyperplasia                  |          3                                                               |             
      Cornea, Inflammation, Chronic Active |          3                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +  +        +     +        +                                       |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Casts                                | 2              2        1              2                                 |             
      Cyst                                 |                            X                                            X|             
      Glomerulosclerosis                   | 2                                                                        |             
      Hydronephrosis                       |                                                             2            |             
      Infarct                              |                                                       2                  |             
      Inflammation, Chronic                | 2  4  2  2     3     2           1  2  1  2        2     2     2  2  2   |             
      Inflammation, Suppurative            |                                                             2        1   |             
      Cortex, Necrosis                     |                                                                          |             
      Renal Tubule, Atrophy                |    4                                      2                              |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Regeneration           | 1     1     1  2                 1  2  2  3        1  1     2     1  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                             X            |             
      Fibrosis                             |                                                             3            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                  2              2                        |             
      Inflammation, Suppurative            |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2|            |
                                           | 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    20.0                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  M  +  +  +  M  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  M|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cecum, Serosa, Ectopic Tissue        |             X                                                            |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |            |
           Lymphoid                        |    3                                                           2         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                        2                                 |      1  2.0|
      Clear Cell Focus                     |                                                                          |      2     |
      Eosinophilic Focus                   |                                        X                                 |      1     |
      Hematopoietic Cell Proliferation     | 2                                3                 2                     |      4  2.5|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                    3     2               |      5  2.4|
      Mineralization                       |                         4                                                |      1  4.0|
      Hepatocyte, Karyomegaly              |                               2  2                                       |      2  2.0|
      Hepatocyte, Necrosis                 |                                  4                                       |      3  3.3|
      Hepatocyte, Vacuolization Cytoplasmic|    2  2                 2                       3                        |     10  2.1|
      Kupffer Cell, Hyperplasia            |                                                                         X|      1     |
      Kupffer Cell, Pigmentation           |                         4                                                |      1  4.0|
      Vein, Thrombosis                     |                                                          3               |      1  3.0|
      Vein, Adventitia, Fibrosis           |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                         +        +                 +   |   8        |
      Fibrosis                             |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                                           3                          3   |      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                                     2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    2  2                             2                 3                  |      8  2.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Hyperplasia             |             2              1                       2  2           2  3   |      9  2.2|
      Forestomach, Inflammation, Chronic   |                                                                          |      1  2.0|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                   2  2   |      2  2.0|
      Glandular, Cyst                      |                                                                          |      1     |
      Glandular, Mineralization            |             3                          2  2                              |      3  2.3|
                                            __________________________________________________________________________|____________|
   Tooth                                   |             +                                                            |   4        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2|            |
                                           | 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    20.0                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Developmental Malformation           |             X                                                            |      3     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                           2                              |      1  2.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Developmental Malformation           |                                                                          |      2     |
      Cortex, Atrophy                      |                                                                3         |      1  3.0|
      Cortex, Hyperplasia, Focal           |                                        2                                 |      1  2.0|
      Medulla, Hyperplasia                 |                3                       3                                 |      2  3.0|
      Spindle Cell, Hyperplasia            |          2     2        2           3  3  3        2     2     2  2     2|     21  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |             3                                                            |      7  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +|  43        |
      Crystals                             |                                                                          |      1  3.0|
      Cyst                                 |                                                                   X      |      2     |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  I  M  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M|  40        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Mineralization                       |             1                                                            |      1  1.0|
      Follicle, Dilatation                 | 3                                                                        |      3  3.0|
      Follicular Cell, Hyperplasia         |                         2                                                |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |             +                                                            |   1        |
      Dilatation                           |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                 2                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2|            |
                                           | 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    20.0                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +           +  +                 M  +                    +         |  11        |
      Ectasia                              |                                                                2         |      5  2.4|
      Inflammation, Chronic                |       4              3                    2                              |      7  2.9|
      Inflammation, Suppurative            |                   4  2                                                   |      5  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |       2     2                                                            |      2  2.0|
      Inflammation, Suppurative            |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +     +                                                      |   5        |
      Dilatation                           |             4                                                            |      1  4.0|
      Fibrosis                             |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Seminiferous Tubule, Atrophy         |                                                                2  2      |      2  2.0|
      Seminiferous Tubule, Mineralization  |       2                                                        3  2      |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3           2                 2  3  3        3              4            |     10  3.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Histiocytic   |                      3                                                   |      2  3.0|
      Inguinal, Hyperplasia, Plasma Cell   |                               3                                          |      2  3.0|
      Inguinal, Pigmentation               | 3              3                                                         |      4  2.8|
      Lymphatic, Mandibular, Ectasia       |                                              3                           |      1  3.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                 3                        |      1  3.0|
      Mandibular, Hyperplasia, Plasma Cell |             3                 3                             3            |      5  3.0|
      Mesenteric, Angiectasis              |                                                                          |      1  4.0|
      Mesenteric, Atrophy                  |                   3                                                      |      1  3.0|
      Mesenteric, Congestion               |                                                                          |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                  3                                       |      4  2.5|
      Mesenteric, Hemorrhage               |    2     3  4     3     3  2  4                                3         |     14  2.9|
      Mesenteric, Hyperplasia, Histiocytic |                                                                          |      1  3.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                     4     4                              |      3  3.7|
      Mesenteric, Hyperplasia, Plasma Cell |                                                                          |      1  3.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Mast Cell                       |                                                                          |      1  2.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Megakaryocyte                   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2|            |
                                           | 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    20.0                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Hyperplasia, Histiocytic      |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                        4                    3            |      5  3.6|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |          2        3                          2  3  4                     |      9  2.8|
      Hyperplasia, Lymphoid                |                                           3                              |      1  3.0|
      Hyperplasia, Plasma Cell             |                               3                                          |      1  3.0|
      Necrosis, Focal                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +|  36        |
      Cyst                                 |                                     X                    X               |      7     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                   X  3  3     3           2  4     1  3  2  3  2     3   |     18  2.5|
      Edema                                |                                              3                           |      1  3.0|
      Erosion                              |                                                                          |      2  3.0|
      Exudate                              |                                                             2        2   |      2  2.0|
      Fibrosis                             |                                                                          |      1  4.0|
      Foreign Body                         |                                                                          |      1  3.0|
      Fungus                               |                4                                                         |      1  4.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic                |                   2     2     3                                2     3   |      7  2.4|
      Inflammation, Chronic Active         |          2              3                                                |      3  3.0|
      Inflammation, Granulomatous          |                4                                                         |      2  3.5|
      Inflammation, Suppurative            |                                                          4               |      1  4.0|
      Ulcer                                |                      3  2     X              3                           |      6  2.8|
      Sebaceous Gland, Hyperplasia         |                                                                      2   |      1  2.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +  +  +|  47        |
      Necrosis                             |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                              +              +           +|   4        |
      Foreign Body                         |                                                                         2|      1  2.0|
      Hemorrhage                           |                                                             3            |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                         3|      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2|            |
                                           | 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    20.0                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                             3            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebrum, Vacuolization Cytoplasmic  |                                                                         3|      1  3.0|
      Hippocampus, Infiltration Cellular,  |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
      Thalamus, Mineralization             | 2        2  2           3  2  3     3  2  2        2  2  3  2  1     2  4|     25  2.2|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  M  +  +  +  +  +|  42        |
      Degeneration                         |                         2                                                |      1  2.0|
      Inflammation, Chronic                |                      1                                                   |      2  2.5|
      Inflammation, Subacute               |                                                                         2|      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                  3        3                              |      3  3.0|
      Infiltration Cellular, Eosinophil    |                                     2                                    |      1  2.0|
      Infiltration Cellular, Histiocyte    |    2                          3                                2         |      5  2.6|
      Inflammation, Chronic                | 2     2  1     2        2           2        2        3  2     2        2|     17  2.0|
      Inflammation, Suppurative            |          1              2                 2                             2|      9  1.9|
      Thrombosis                           |                                                                          |      1     |
      Bronchus, Foreign Body               |                                           2                              |      1  2.0|
      Capillary, Infiltration Cellular,    |                                                                          |            |
           Polymorphonuclear               |                               4                                          |      1  4.0|
      Interstitium, Edema                  |                                              2                           |      3  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Fungus                               |                                                    3                     |      2  3.0|
      Inflammation, Suppurative            |       3  3     3              4        3  3        3  3        2     3   |     16  2.8|
      Mucosa, Metaplasia, Squamous         |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                           3                              |      1  3.0|
      Submucosa, Cyst                      | X                                                                        |      1     |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                M                                                         |   1        |
      Cornea, Hyperplasia                  |                                                                          |      1  3.0|
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +           +                    +                     |   8        |
      Cyst                                 |                               X                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2|            |
                                           | 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    20.0                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                  4                                       |      1  4.0|
      Casts                                |                                                                   1      |      5  1.6|
      Cyst                                 |                                                                          |      2     |
      Glomerulosclerosis                   |                   1                                               2      |      3  1.7|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Chronic                | 2     3              2     2  2                       2  2     2  2  3  3|     26  2.2|
      Inflammation, Suppurative            |                                  4                                       |      3  2.3|
      Cortex, Necrosis                     |                                  4                                       |      1  4.0|
      Renal Tubule, Atrophy                |                                                       2  2               |      4  2.5|
      Renal Tubule, Mineralization         |             4                                                            |      1  4.0|
      Renal Tubule, Regeneration           |    1  1                 1              1  1           1           1     1|     22  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Calculus Micro Observation Only      |             X                                                            |      2     |
      Fibrosis                             |                                                                          |      1  3.0|
      Hemorrhage                           |             3                                                            |      1  3.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|             
                                           | 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10.0                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  M  M  +  +  +  +  M  +  +  A  +  +  +  +  +  +  M  M  +  +  M  I  +  +|             
      Amyloid Deposition                   |             3                                                            |             
      Inflammation, Suppurative            |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duodenum, Ulcer                      |                                                                          |             
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |             
           Lymphoid                        |                                                                         2|             
      Serosa, Jejunum, Cyst                |          X                                                               |             
      Serosa, Jejunum, Inflammation,       |                                                                          |             
          Granulomatous                    |          3                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |             3                                                     2      |             
      Inflammation, Chronic Active         |                         1                                                |             
      Bile Duct, Cyst                      |                                                                   X      |             
      Hepatocyte, Cytoplasmic Alteration   |    2     2                                                               |             
      Hepatocyte, Karyomegaly              |                                                 3                        |             
      Hepatocyte, Necrosis                 | 1                             4                    4                     |             
      Hepatocyte, Vacuolization Cytoplasmic|          2     3                    3                                    |             
      Kupffer Cell, Hyperplasia            |                                  3        3                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                                                                   3      |             
      Artery, Necrosis                     |                                                                          |             
      Artery, Thrombosis                   |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                   3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |                                                                      4   |             
      Cyst                                 |             X                                                        X   |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |                                  2                                   2   |             
      Inflammation, Suppurative            |                                                                      2   |             
      Artery, Inflammation, Chronic        |             2                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       1                             2                          2         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Hyperplasia             |                            2                                         2   |             
      Forestomach, Inflammation, Chronic   |                                                                      2   |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Forestomach, Inflammation,           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|             
                                           | 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10.0                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Suppurative                      |                                                                          |             
      Forestomach, Mineralization          |                                                                          |             
      Glandular, Erosion                   |                                                    2                     |             
      Glandular, Inflammation, Suppurative |             2                                                            |             
      Glandular, Mineralization            |       2                    2                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +  +  +                          +  +                             +  +|             
      Developmental Malformation           |    X  X  X                          X  X                             X  X|             
      Foreign Body                         |    3                                                                     |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |    3                                                                     |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                        3                             3   |             
      Pulp, Inflammation, Suppurative      |          3                             3                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |             2                                                            |             
      Myocardium, Inflammation, Chronic    |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Cortex, Hyperplasia, Focal           |                         2                                                |             
      Cortex, Vacuolization Cytoplasmic    |    2                    2                                                |             
      Medulla, Hyperplasia                 |                                  2                                       |             
      Spindle Cell, Hyperplasia            |    2  1     2        2  2  2        2  2  3           2     2           2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |       2  2                          3  2                          2     3|             
      Infiltration Cellular, Lymphocyte    |                                  3                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | I  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                        X     X                           |             
      Pars Distalis, Hyperplasia           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Dilatation                 |    3                                                           2     3   |             
      Follicular Cell, Hyperplasia         | 3                                      2                 2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|             
                                           | 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10.0                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   3      |             
      Inflammation, Granulomatous          |                                                          3               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +        +           +                          +           +  +|             
      Ectasia                              |       2  3        3           3                          3           3  2|             
      Inflammation, Chronic                |       3  3        3                                      3              2|             
      Inflammation, Suppurative            |                                                          3               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                       3                  |             
      Inflammation, Chronic                |                            2                          4     3            |             
      Inflammation, Suppurative            |                                                       4     3            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                           +           +     +            |             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |                                                       4     3            |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                                          |             
      Seminiferous Tubule, Mineralization  |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                     +                                    |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                             4     2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Histiocytic   |                            4                                             |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                                                                          |             
      Inguinal, Pigmentation               |                                  3                                       |             
      Mandibular, Hyperplasia, Lymphoid    |                                     3                                    |             
      Mandibular, Hyperplasia, Plasma Cell |                                                          3               |             
      Mandibular, Pigmentation             |                                                    3                     |             
      Mesenteric, Angiectasis              |                                  3                                       |             
      Mesenteric, Atrophy                  |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                     3                       3            |             
      Mesenteric, Hemorrhage               |       2     3        4                 3  4              2  2  3     2  4|             
      Mesenteric, Hyperplasia, Plasma Cell |                                                       2                  |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Polymorphonuclear               |                                           3                              |             
      Mesenteric, Lymphatic, Ectasia       |                                                             2            |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
      Renal, Lymphatic, Ectasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|             
                                           | 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10.0                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     | 2                                         2                 3            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |             2     3           3     3                 3                  |             
      Hyperplasia, Lymphoid                |                                  2  2                                    |             
      Hyperplasia, Megakaryocyte           |                                           3                              |             
      Lymphoid Follicle, Atrophy           |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  M  +  M  +  M  +  M  M  M  +  M  +  +  +  +  +|             
      Atrophy                              |                                                             3            |             
      Cyst                                 |    X                                X                 X              X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Acanthosis                           |                   3  2     3  2        3        2              3     3   |             
      Acanthosis, Multiple                 |                                                                          |             
      Edema                                |                               3                                         3|             
      Exudate                              |                                                                      2   |             
      Fibrosis                             |                            2                    3                        |             
      Fungus                               |                                                                          |             
      Inflammation, Chronic                |                      2                 2                       2         |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                            3                                             |             
      Inflammation, Suppurative            |                            3                    3                        |             
      Ulcer                                |                   3                                                      |             
      Lymphatic, Angiectasis               |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                         3                                            3   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
      Inflammation, Chronic                |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             | 2  2     3  1        2  2  2     3     2              2  3  2  1     2   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |    3                 4                    2           2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|             
                                           | 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10.0                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |       2     1        3        2     3                                    |             
      Inflammation, Suppurative            |       2              3                                                   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Glands, Ectasia                      |                                                                          |             
      Interstitium, Edema                  |                               2                    2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                        2  2                              |             
      Glands, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts                                |    3        2  1                 2        2     3                        |             
      Congestion                           |                                                                          |             
      Cyst                                 |       X     X           X                             X  X     X         |             
      Glomerulosclerosis                   |    2                             2              1                        |             
      Hydronephrosis                       |                                                       2                  |             
      Inflammation, Chronic                |    3        3  1        2  1  2     2                 4  2     2        1|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                             2            |             
      Metaplasia, Osseous                  |                                                                          |             
      Renal Tubule, Atrophy                |             2                                         3                  |             
      Renal Tubule, Mineralization         |       1                                                                  |             
      Renal Tubule, Regeneration           |    3  1  1              1        3  1  1        3        2        1     1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               3                                          |             
      Inflammation, Chronic                | 2                                2                    3                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Mucosa, Hyperplasia                  |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2|            |
                                           | 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10.0                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  I  +  +  +|  35        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duodenum, Ulcer                      |                3                                                         |      1  3.0|
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |            |
           Lymphoid                        |          3                                                               |      2  2.5|
      Serosa, Jejunum, Cyst                |                                                                          |      1     |
      Serosa, Jejunum, Inflammation,       |                                                                          |            |
          Granulomatous                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                                     X                                    |      1     |
      Hematopoietic Cell Proliferation     |                      2                       2              4            |      3  2.7|
      Inflammation, Chronic                |                   2                                                      |      3  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Hepatocyte, Cytoplasmic Alteration   |                                                                          |      2  2.0|
      Hepatocyte, Karyomegaly              |                               2                                          |      2  2.5|
      Hepatocyte, Necrosis                 |                                                             4            |      4  3.3|
      Hepatocyte, Vacuolization Cytoplasmic|          2  1                                      1                     |      6  2.0|
      Kupffer Cell, Hyperplasia            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +     +           +                    +           +|   6        |
      Hemorrhage                           |                                                                         4|      1  4.0|
      Mineralization                       |                                                                          |      1  3.0|
      Artery, Necrosis                     |                      3                                                   |      1  3.0|
      Artery, Thrombosis                   |                                                                         X|      1     |
      Fat, Necrosis, Focal                 |                            3           4                                 |      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      2     |
      Hyperplasia, Focal                   |                                  3                                       |      1  3.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                               1  2  3              2              3      |      8  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2|            |
                                           | 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10.0                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Hyperplasia             |             3                    3                                3      |      5  2.6|
      Forestomach, Inflammation, Chronic   |                                                                          |      1  2.0|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                   3     2|      2  2.5|
      Forestomach, Inflammation,           |                                                                          |            |
          Suppurative                      |                                  3                                       |      1  3.0|
      Forestomach, Mineralization          |             3                                                            |      1  3.0|
      Glandular, Erosion                   |    2                                                                     |      2  2.0|
      Glandular, Inflammation, Suppurative |                                                          2               |      2  2.0|
      Glandular, Mineralization            |                                           2                              |      3  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                            +                                         +  +|  10        |
      Developmental Malformation           |                            X                                         X  X|     10     |
      Foreign Body                         |                                                                          |      1  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  3.0|
      Pulp, Inflammation, Suppurative      |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                               2                                          |      2  2.0|
      Myocardium, Inflammation, Chronic    |                                                             2            |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Developmental Malformation           |                                                                      X   |      1     |
      Cortex, Hyperplasia, Focal           |       2  2                          2                                    |      4  2.0|
      Cortex, Vacuolization Cytoplasmic    |                                                                          |      2  2.0|
      Medulla, Hyperplasia                 |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            |       2  2  2        1        2  2  2  2  2  3  2  2              2  2  2|     27  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |    3  2     4        2     4                                   2     2   |     13  2.5|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  I  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  M|  40        |
      Cyst                                 |                                     X                                    |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  I  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  44        |
      Pars Distalis, Cyst                  |                         X                                      X         |      4     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2|            |
                                           | 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10.0                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia           |                                                                3         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Dilatation                 |                                                                          |      3  2.7|
      Follicular Cell, Hyperplasia         |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                   +                                               +      |   2        |
      Hemorrhage                           |                                                                   4      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +        +           +     +     +                                   +  +|  14        |
      Ectasia                              | 3        4                       3                                   3  4|     12  3.0|
      Inflammation, Chronic                |                            4                                             |      6  3.0|
      Inflammation, Suppurative            |                      4     4                                             |      3  3.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                      4                                                   |      4  3.3|
      Inflammation, Suppurative            |                      4                                                   |      3  3.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                      +                          +                        |   5        |
      Fibrosis                             |                                                 3                        |      1  3.0|
      Inflammation, Suppurative            |                      4                                                   |      3  3.7|
      Pigmentation                         |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Seminiferous Tubule, Atrophy         |       2     3  2     2                             1           2        2|      7  2.0|
      Seminiferous Tubule, Mineralization  |                      2                          1        2               |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      4        3                                3        2|      7  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Inguinal, Hyperplasia, Histiocytic   |                                                                          |      1  4.0|
      Inguinal, Hyperplasia, Plasma Cell   |                               3                                          |      1  3.0|
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                                                                   3      |      1  3.0|
      Inguinal, Pigmentation               | 3  3                             3                                       |      4  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2|            |
                                           | 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10.0                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Mandibular, Hyperplasia, Plasma Cell |                3                                                         |      2  3.0|
      Mandibular, Pigmentation             |                      3                                                   |      2  3.0|
      Mesenteric, Angiectasis              |                                                 3                        |      2  3.0|
      Mesenteric, Atrophy                  |    3                                                                     |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                3     4        3                             3            |      6  3.2|
      Mesenteric, Hemorrhage               |                         2           2  4           2                     |     14  2.8|
      Mesenteric, Hyperplasia, Plasma Cell |                                                                          |      1  2.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Polymorphonuclear               |                                                                          |      1  3.0|
      Mesenteric, Lymphatic, Ectasia       |                                        3                                 |      2  2.5|
      Renal, Hemorrhage                    |                      3                                                   |      1  3.0|
      Renal, Hyperplasia, Plasma Cell      |                      3                                                   |      1  3.0|
      Renal, Lymphatic, Ectasia            |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                      3                                                   |      4  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                3              3           3           3        3         |     10  2.9|
      Hyperplasia, Lymphoid                |                                              3                           |      3  2.3|
      Hyperplasia, Megakaryocyte           |                                                                          |      1  3.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  M  M  +  M  M  +  M  +|  32        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |          X                 X              X                              |      7     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                   2  3        3     3        X  2  2     2               |     16  2.5|
      Acanthosis, Multiple                 |                                           3                              |      1  3.0|
      Edema                                |                                                    3                     |      3  3.0|
      Exudate                              |                                                                          |      1  2.0|
      Fibrosis                             |                   2                                                      |      3  2.3|
      Fungus                               |                   4                                                      |      1  4.0|
      Inflammation, Chronic                |                      2        3     2           1                        |      7  2.0|
      Inflammation, Chronic Active         |                                              3                           |      1  3.0|
      Inflammation, Granulomatous          |                   4                                                      |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2|            |
                                           | 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10.0                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                         2                                                |      4  2.5|
      Ulcer                                |                                           3                              |      3  2.7|
      Lymphatic, Angiectasis               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia                            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thalamus, Mineralization             |             2        1  3        2     2        2     2  2  2  2  2  3   |     26  2.1|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                        2                                 |      1  2.0|
      Infiltration Cellular, Histiocyte    |       4  2              2                                      2         |      8  2.6|
      Inflammation, Chronic                |                                     2  1           2     2              2|     10  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |             2           1     2        2                                 |      4  1.8|
      Glands, Ectasia                      |                                                          3               |      1  3.0|
      Interstitium, Edema                  |                2                                            2            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 2              2                                                        3|      5  2.2|
      Glands, Cyst                         |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                 +                        |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Casts                                |    3           4                                1     1        1         |     11  2.1|
      Congestion                           |                                                                3         |      1  3.0|
      Cyst                                 |                X                    X                                    |      8     |
      Glomerulosclerosis                   |                3                                                         |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2|            |
                                           | 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10.0                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic                |    3     1  2  4     2  1  2  1  1  3  1        1           3     2  1  2|     27  2.0|
      Inflammation, Chronic Active         |                                                                3         |      1  3.0|
      Inflammation, Suppurative            |                      3                                                   |      2  2.5|
      Metaplasia, Osseous                  |    2                          2                                          |      2  2.0|
      Renal Tubule, Atrophy                |          2                                                        2      |      4  2.3|
      Renal Tubule, Mineralization         |                                  1                                   1   |      3  1.0|
      Renal Tubule, Regeneration           |    3     2     4  2     1  1     2        1     1     1        3  2  1   |     24  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                              3                           |      4  2.5|
      Inflammation, Chronic Active         |                      3                                                   |      1  3.0|
      Mineralization                       |                                                       1                  |      1  1.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
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