Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/2612

TDMS Study 05049-02 Pathology Tables

NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97
Route: GAVAGE                                                                                                     Time: 12:38:06




       Facility:  Southern Research Institute

       Chemical CAS #:  62-73-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Necrosis                             |                               2                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  +  +  M  A  +  +  +  +  +  +  M  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Hyperplasia, Lymphoid         |          3                                         3                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duodenum, Hyperplasia, Re Cell       |                      3                                                   |             
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |             
           Mononuclear Cell                |                                                                3         |             
      Mucosa, Ileum, Dysplasia             |          3                                                               |             
      Submucosa, Ileum, Infiltration       |                                                                          |             
          Cellular, Plasma Cell            |          2                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      3           2                    3        4  3      |             
      Inflammation, Chronic                |    2     3              2              2  1  2  1  2     2  1        3   |             
      Inflammation, Chronic Active         |       2                                                                 2|             
      Bile Duct, Cyst                      |                                                                          |             
      Hepatocyte, Cytoplasmic Alteration   |                                                                          |             
      Hepatocyte, Karyomegaly              |                                                                          |             
      Hepatocyte, Necrosis                 |       1     2                                                            |             
      Hepatocyte, Vacuolization Cytoplasmic|       2                                   2                              |             
      Kupffer Cell, Hyperplasia            |             3                                                            |             
      Kupffer Cell, Pigmentation           |             2                                         3                  |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                +              +        +     +     +   |             
      Inflammation, Chronic                | 2                                                                        |             
      Inflammation, Suppurative            | 2                                                              3         |             
      Artery, Hypertrophy                  |                                                          3               |             
      Artery, Inflammation, Chronic        |                                                 3        4               |             
      Fat, Necrosis, Focal                 |                                                                      4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                4         |             
      Cytoplasmic Alteration               |                                        2                                 |             
      Hyperplasia, Focal                   |       2                                                                  |             
      Infarct                              |       2                                                                  |             
      Inflammation, Chronic                |                            2        2                          4         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          2              2                 2                 2     3      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Cyst                    |       X                                                                  |             
      Forestomach, Diverticulum            |          X                                                               |             
      Forestomach, Erosion                 |                                           3                              |             
      Forestomach, Hyperplasia, Focal      |                                  1        2                       2      |             
      Forestomach, Inflammation, Acute     |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
      Glandular, Edema                     |                                                                          |             
      Glandular, Erosion                   |                                                                          |             
      Glandular, Inflammation, Chronic     |             2                                                            |             
      Glandular, Inflammation, Suppurative |                                                                3         |             
      Glandular, Mineralization            |             2                                            2           2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                          +               |             
      Inflammation, Chronic, Multiple      |                                                          3               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                          3               |             
      Coronary Artery, Media, Hypertrophy  |                                                          4               |             
      Myocardium, Angiectasis              |                         2                                                |             
      Myocardium, Fibrosis                 |       1                                                  2               |             
      Myocardium, Inflammation, Chronic    | 2                                                              2         |             
      Myocardium, Inflammation, Suppurative|                                                       4                  |             
      Pericardium, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                       2        3         |             
      Cortex, Cyst                         |                         X                                                |             
      Cortex, Degeneration, Fatty          |                                           3                              |             
      Cortex, Developmental Malformation   |                                                                   X      |             
      Cortex, Hyperplasia, Focal           |                                                                          |             
      Medulla, Vacuolization Cytoplasmic   |                                                                          |             
      Spindle Cell, Hyperplasia            |    3  2  3  2     3  2  2  2     3  3  2  2  2  3  3  3  3  3  3  3  3  3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  A  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                                   X                                 |             
      Ectopic Thymus                       |                                                             X            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      3   |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    2     3  2                                2  3                    3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       3                             2                                    |             
      Inflammation, Suppurative            |                                                                          |             
      Follicle, Dilatation                 |             4           2              3                                 |             
      Follicular Cell, Hyperplasia         |       3                 2              2        2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +              +                                          |             
      Foreign Body                         |                4              4                                          |             
      Inflammation, Suppurative            |                4              4                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |    X        X                    X     X              X  X           X  X|             
      Hemorrhage                           |             2                                         4                  |             
      Inflammation, Chronic                |                                                                      4   |             
      Inflammation, Suppurative            | 4                                            4     4           4     4   |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         3                                                |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  | 3  3  3  4  4     4  4  4  3     3     3  3  3  3  3  3  2  2  2  3  3  4|             
      Hyperplasia, Cystic, Multiple        |                                     4                                    |             
      Hyperplasia, Glandular               |                         3                                                |             
      Inflammation, Chronic                |                                                 3                        |             
      Inflammation, Suppurative            |                                                 3  3           4     3   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                A                                      +                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                 3                             3  3  2        4  4  3   |             
      Hyperplasia, Reticulum Cell          |          2                                                               |             
      Myelofibrosis                        |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +|             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                   2                                                      |             
      Inguinal, Hyperplasia, Lymphoid      |          3                                                               |             
      Lymphatic, Mandibular, Ectasia       |                                                 3                        |             
      Mandibular, Hyperplasia, Lymphoid    |          2                                                               |             
      Mandibular, Hyperplasia, Plasma Cell |    3                    3                                               3|             
      Mediastinal, Angiectasis             | 3                                                                        |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mesenteric, Angiectasis              |                            3                                             |             
      Mesenteric, Atrophy                  |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                4         |             
      Mesenteric, Hemorrhage               |          4  2              2           2                                 |             
      Mesenteric, Hyperplasia, Histiocytic |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |          3                                                               |             
      Mesenteric, Hyperplasia, Plasma Cell |          3                                                               |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Polymorphonuclear               |                                                                          |             
      Mesenteric, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
      Mesenteric, Lymphatic, Ectasia       |          4                                                               |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                   2                             3              3         |             
      Renal, Inflammation, Suppurative     |                                                                4         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     | 3           3                                      2           4  3      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                      2  2  3     3                    3                  |             
      Hyperplasia, Lymphoid                |          2              2                                            3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                         X        X                                       |             
      Hyperplasia, Lymphoid                |          3                                                               |             
      Necrosis, Diffuse                    |                               3                                          |             
      Medulla, Hyperplasia, Mononuclear    |                                                                          |             
          Cell                             |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                         3  2        2  2                 3  2           3|             
      Hyperplasia, Lobular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |          2  2           2  2     2                       3           3   |             
      Necrosis                             |                                           2                              |             
      Cranium, Hyperostosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                    +                       +               |             
      Inflammation, Chronic                |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Hemorrhage               |                                                                          |             
      Cerebellum, Infiltration Cellular,   |                                                                          |             
           Lymphocyte                      |    2     2                                                               |             
      Cerebrum, Hemorrhage                 |                                                                          |             
      Cerebrum, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |    2                                                                     |             
      Thalamus, Hemorrhage                 |                                                                          |             
      Thalamus, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |    2                                                                     |             
      Thalamus, Mineralization             | 2  1              2        2     2  2     1  2  3  3  2  2  2  2  3  3  2|             
      Vein, Adventitia, Infiltration       |                                                                          |             
          Cellular, Lymphocyte             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                   3                                                      |             
      Inflammation, Chronic                |    3  2  3  3     3  2  2  2     3  2  3  2  2     2     2        2  2  2|             
      Inflammation, Suppurative            | 3                                         2                              |             
      Interstitium, Edema                  |                                                                          |             
      Pleura, Inflammation, Suppurative    | 2              3              3                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                      3                             2           2         |             
      Inflammation, Chronic Active         |    3                                3     3                              |             
      Inflammation, Suppurative            |    4  2     1        3  3        3  2  3  4  3  2  2     3        1  4  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   4                                                      |             
      Glands, Inflammation, Suppurative    |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                             +            |             
      Infiltration Cellular, Lymphocyte    |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts                                |    1  1                    2        1                 2     2        1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 7| 7| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 0| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| 3| 2| 3| 7| 1| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 7| 2| 2| 5| 5| 0| 8| 5| 5| 5| 5| 5| 5| 4| 1| 9| 1| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Glomerulosclerosis                   |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |    3  2  3  2           2        2  2  2  2  2  3     2  2     4  3     2|             
      Inflammation, Suppurative            |                                                                4         |             
      Metaplasia, Osseous                  |                            2                                             |             
      Artery, Inflammation, Chronic        |                                                          4               |             
      Artery, Media, Hypertrophy           |                                                          4               |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Degeneration           |                                                                3         |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Regeneration           |                            2              1     3                    2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  I|             
      Edema                                |                                  3                                       |             
      Inflammation, Chronic                |    2  2  3  2           2        3  3  3           2              3      |             
      Inflammation, Suppurative            |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Diverticulum                         |                                                          X               |      1     |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  M  A  +  M  +  M  +  +  +  +  +  M  A  +  I  +  +  M  +  M  I|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cecum, Hyperplasia, Lymphoid         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  M  +  +  +  +|  46        |
      Duodenum, Hyperplasia, Re Cell       |                                                                          |      1  3.0|
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |            |
           Mononuclear Cell                |                                                                          |      1  3.0|
      Mucosa, Ileum, Dysplasia             |                                                                          |      1  3.0|
      Submucosa, Ileum, Infiltration       |                                                                          |            |
          Cellular, Plasma Cell            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |             3           3           2                                    |      8  2.9|
      Inflammation, Chronic                |       2  2                    2        1                                 |     15  1.9|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Bile Duct, Cyst                      |                         X                                                |      1     |
      Hepatocyte, Cytoplasmic Alteration   |                                           2                              |      1  2.0|
      Hepatocyte, Karyomegaly              |                                                          2               |      1  2.0|
      Hepatocyte, Necrosis                 |    3                                            3     3                  |      5  2.4|
      Hepatocyte, Vacuolization Cytoplasmic|                      3                                               3   |      4  2.5|
      Kupffer Cell, Hyperplasia            |             4           4                                                |      3  3.7|
      Kupffer Cell, Pigmentation           |                                                                   3      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +     +     +        +                 +     +     +         |  13        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |             4     3     3                                                |      5  3.0|
      Artery, Hypertrophy                  |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |                                                                          |      2  3.5|
      Fat, Necrosis, Focal                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |                                                                   2      |      2  3.0|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                       2                  |      4  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Cyst                    |                                                                          |      1     |
      Forestomach, Diverticulum            |                                                                          |      1     |
      Forestomach, Erosion                 |                                                                          |      1  3.0|
      Forestomach, Hyperplasia, Focal      |          1                          2                 2                  |      6  1.7|
      Forestomach, Inflammation, Acute     |                                                                          |      1  2.0|
      Forestomach, Inflammation, Chronic   |                                     2                                    |      1  2.0|
      Glandular, Edema                     |                         3                                                |      1  3.0|
      Glandular, Erosion                   |                                                    3                     |      1  3.0|
      Glandular, Inflammation, Chronic     |                                                                          |      1  2.0|
      Glandular, Inflammation, Suppurative |                         3              2                                 |      3  2.7|
      Glandular, Mineralization            |                                     2              2                     |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation, Chronic, Multiple      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                2         |      2  2.5|
      Coronary Artery, Media, Hypertrophy  |                                                                          |      1  4.0|
      Myocardium, Angiectasis              |                                                                          |      1  2.0|
      Myocardium, Fibrosis                 |                                                                   1      |      3  1.3|
      Myocardium, Inflammation, Chronic    |                                                                          |      2  2.0|
      Myocardium, Inflammation, Suppurative|                   2     2                                                |      3  2.7|
      Pericardium, Inflammation,           |                                                                          |            |
          Suppurative                      | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Cortex, Cyst                         |                                                                          |      1     |
      Cortex, Degeneration, Fatty          |                               3           2                          2   |      4  2.5|
      Cortex, Developmental Malformation   |                                                                          |      1     |
      Cortex, Hyperplasia, Focal           |                                           3                              |      1  3.0|
      Medulla, Vacuolization Cytoplasmic   |                                                    2                     |      1  2.0|
      Spindle Cell, Hyperplasia            |       3  2  3     3  2  3  2     3  3  3  2        2  2  2     3  3  2  2|     40  2.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
      Cyst                                 |             X                                                            |      3     |
      Ectopic Thymus                       |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  45        |
      Angiectasis                          |                                                                          |      1  3.0|
      Pars Distalis, Angiectasis           |       1                 1                                                |      2  1.0|
      Pars Distalis, Cyst                  |                                                                   X      |      1     |
      Pars Distalis, Hyperplasia           |       1                 2        3     2              1           1     1|     13  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                            1                                             |      1  1.0|
      Follicle, Dilatation                 |                            2     3                                3      |      6  2.8|
      Follicular Cell, Hyperplasia         |                         2                                                |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +              +                             +           +  +            |   7        |
      Foreign Body                         | 4              4                             4              3            |      6  3.8|
      Inflammation, Suppurative            | 4              4                             4              3            |      6  3.8|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |       X  X        X        X        X                    X     X  X  X  X|     18     |
      Hemorrhage                           |                                                          3               |      3  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |             4     4                                                      |      7  4.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hydrometra                           | 3                                                                        |      1  3.0|
      Hyperplasia, Cystic                  |    3  4  4  2     3  3  3  3  3  2  3  2  2           3        3  2  3  4|     40  3.0|
      Hyperplasia, Cystic, Multiple        |                                                                          |      1  4.0|
      Hyperplasia, Glandular               |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                        3                                 |      2  3.0|
      Inflammation, Suppurative            | 2           4     2                 3                                    |      8  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |       +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      2  3        3                 3  3           4      |     14  3.1|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
      Myelofibrosis                        |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Iliac, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                   3      |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         |                               2                                          |      1  2.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  3.0|
      Lymphatic, Mandibular, Ectasia       |                                                                          |      1  3.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |      3  3.0|
      Mediastinal, Angiectasis             |                                                                          |      1  3.0|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                         3                                                |      1  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                         3                                                |      1  3.0|
      Mesenteric, Angiectasis              |                                                                          |      1  3.0|
      Mesenteric, Atrophy                  |                                                                          |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                     3                             3      |      3  3.3|
      Mesenteric, Hemorrhage               |                               3     2                 3                  |      7  2.6|
      Mesenteric, Hyperplasia, Histiocytic |          3                                                               |      1  3.0|
      Mesenteric, Hyperplasia, Lymphoid    |             3                                                            |      2  3.0|
      Mesenteric, Hyperplasia, Plasma Cell |                                                                          |      1  3.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Polymorphonuclear               |                                                       3                  |      1  3.0|
      Mesenteric, Inflammation,            |                                                                          |            |
          Granulomatous                    |                   2                                                      |      1  2.0|
      Mesenteric, Lymphatic, Ectasia       |                                                                          |      1  4.0|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                   3      |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                   2                                                      |      1  2.0|
      Renal, Hyperplasia, Plasma Cell      |                   3                                                      |      4  2.8|
      Renal, Inflammation, Suppurative     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |             4           4           3                                    |      8  3.3|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                   2  3                                4           3      |      9  2.8|
      Hyperplasia, Lymphoid                |                                                                      3   |      4  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  I  M  M  M  +  +  +  +  M  +  +|  41        |
      Atrophy                              | 3              4                                                         |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      2     |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Necrosis, Diffuse                    |                                                             3            |      2  3.0|
      Medulla, Hyperplasia, Mononuclear    |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Hyperplasia, Cystic                  |                         4  3  2           3           2                  |     12  2.6|
      Hyperplasia, Lobular                 |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                   2      |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                   1      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |       3  3           2  2  2     2  3  2                                 |     15  2.3|
      Necrosis                             |                                                                          |      1  2.0|
      Cranium, Hyperostosis                |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                                    |   4        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebellum, Hemorrhage               |                                                 3                        |      1  3.0|
      Cerebellum, Infiltration Cellular,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  2.0|
      Cerebrum, Hemorrhage                 |                                                 3                        |      1  3.0|
      Cerebrum, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Thalamus, Hemorrhage                 |                                                 3                        |      1  3.0|
      Thalamus, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Thalamus, Mineralization             |    2     3           2  3  3                    2              2         |     24  2.2|
      Vein, Adventitia, Infiltration       |                                                                          |            |
          Cellular, Lymphocyte             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | M  M  +  +  +  M  M  I  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +|  41        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                       4                  |      1  4.0|
      Infiltration Cellular, Histiocyte    |       3                                                                  |      2  3.0|
      Inflammation, Chronic                |       3  2        2        2           2                                2|     24  2.3|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Interstitium, Edema                  | 3                                                  2     2               |      3  2.3|
      Pleura, Inflammation, Suppurative    | 4              4  3                          3              3            |      8  3.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +|  43        |
      Foreign Body                         |                                                    3                     |      1  3.0|
      Inflammation, Chronic                |                                  3                                       |      4  2.5|
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
      Inflammation, Suppurative            |          2  2        2        2  3  3  4           4              3     2|     26  2.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                       3                  |      2  3.5|
      Glands, Inflammation, Suppurative    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                     +  +                                 |   3        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Casts                                |                   2  2        1                    2     3               |     12  1.7|
      Cyst                                 |       X                                                                  |      1     |
      Glomerulosclerosis                   |                                                          2               |      1  2.0|
      Infarct                              |                   3                                                      |      1  3.0|
      Inflammation, Chronic                |       3  2  2     2  3  2  2  1     3  2              2           2  1  2|     30  2.2|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Metaplasia, Osseous                  |                                  2                                       |      2  2.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
      Artery, Media, Hypertrophy           |                                                                          |      1  4.0|
      Renal Tubule, Atrophy                |                            2        2                             2      |      3  2.0|
      Renal Tubule, Degeneration           |                                                                          |      1  3.0|
      Renal Tubule, Dilatation             |                               2                                          |      1  2.0|
      Renal Tubule, Regeneration           |                      2        1                          3        2      |      8  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +|  44        |
      Edema                                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 6| 7| 7| 7| 0| 6| 6| 6| 7| 7| 7| 7| 7| 4| 0| 5| 5| 7| 6| 0| 4| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 3| 3| 0| 0| 2| 6| 9| 3| 3| 3| 3| 3| 2| 0| 6| 8| 0| 3| 0| 5| 0| 3| 3|            |
                                           | 9| 1| 5| 5| 9| 9| 5| 9| 3| 5| 5| 5| 5| 5| 7| 9| 8| 2| 6| 3| 8| 2| 7| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |          2                 3  3     3  3           2  3        3     3   |     19  2.6|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    40.0                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Mucosa, Necrosis              |                               1                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duodenum, Amyloid Deposition         |                                                                          |             
      Ileum, Amyloid Deposition            |                                                          4               |             
      Jejunum, Amyloid Deposition          |                                                          2               |             
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |             
           Lymphoid                        |                                                          2               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                                      X   |             
      Fibrosis                             | 3                                                                        |             
      Hematopoietic Cell Proliferation     |       2  3        3                                                      |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                  3                                       |             
      Inflammation, Chronic                |       3                    2                    3  2     2  3  3     2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Hepatocyte, Cytoplasmic Alteration   |                      3                                                   |             
      Hepatocyte, Karyomegaly              |                   3                                                      |             
      Hepatocyte, Necrosis                 | 4        3  2                       3                                3   |             
      Hepatocyte, Vacuolization Cytoplasmic|                               3                 2     2              2   |             
      Kupffer Cell, Hyperplasia            |       3  3  4                                                  3         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +     +                                                  +     +   |             
      Inflammation, Suppurative            |             4                                                            |             
      Fat, Inflammation, Chronic Active    |                                                                      3   |             
      Fat, Mineralization                  |    2                                                           3     3   |             
      Fat, Necrosis, Focal                 |    3                                                           3     3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cytoplasmic Alteration               |          4                                                               |             
      Inflammation, Chronic                |                            2                                             |             
      Acinus, Vacuolization Cytoplasmic    |                               3                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          2                                               1               |             
      Inflammation, Suppurative            |          2                                                               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Diverticulum            |                                                                          |             
      Forestomach, Foreign Body            |                                                                          |             
      Forestomach, Hyperplasia, Focal      |                                           2              2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    40.0                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                        2                                 |             
      Forestomach, Inflammation,           |                                                                          |             
          Suppurative                      |       4                                                                  |             
      Glandular, Atrophy                   |             3                                                            |             
      Glandular, Inflammation, Suppurative |                                                                          |             
      Glandular, Metaplasia, Squamous      |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                         +                                                |             
      Aorta, Mineralization                |                         2                                                |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endocardium, Inflammation, Chronic   |                                                                          |             
          Active                           |          3                                                               |             
      Myocardium, Inflammation, Chronic    | 2                                                                        |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
          Active                           |          3                                                               |             
      Myocardium, Mineralization           |                      4                                                   |             
      Ventricle, Embolus Bacterial         |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Degeneration, Fatty          |                                                                          |             
      Cortex, Necrosis                     |             2                                                            |             
      Medulla, Angiectasis                 |                                                                          |             
      Spindle Cell, Hyperplasia            | 3  3  3  3  3     2  2  3  2  3  2  2  3  3     3  3  3  2  3  3  3  2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               3  3                                   2   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3              2                                2                  |             
      Pars Distalis, Angiectasis           |          2                                                               |             
      Pars Distalis, Cyst                  |                                                             X            |             
      Pars Distalis, Hyperplasia           |       3  3                    2  3  3           1              2     1   |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                          2               |             
      Follicle, Dilatation                 |                                                             3            |             
      Follicle, Hyperplasia                |                                                                          |             
      Follicular Cell, Hyperplasia         |       3                                                              2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    40.0                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis                          |       3                          2                                       |             
      Cyst                                 |    X  X  X                                X     X  X           X        X|             
      Hemorrhage                           | 3        3                                                  2           3|             
      Inflammation, Suppurative            |             4     4                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                                                |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  | 3  2  4  2  3     2  4  3  3     2  3  4  4     3  3  3  3  3  4  3  3  3|             
      Hyperplasia, Glandular               |                                  3                                       |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |             4     4                                                      |             
      Endometrium, Vacuolization           |                                                                          |             
          Cytoplasmic                      |                                                                          |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                               +                                          |             
      Hyperplasia, Squamous                |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2           4                                                      |             
      Hyperplasia, Reticulum Cell          |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |             
      Mandibular, Necrosis, Diffuse        |                               2                                          |             
      Mandibular, Pigmentation             |                               3           3                 3            |             
      Mediastinal, Hyperplasia, Histiocytic|             4                                                            |             
      Mesenteric, Angiectasis              |                   3                                                      |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                   2                                                      |             
      Mesenteric, Hemorrhage               |             2                          2                                 |             
      Mesenteric, Hyperplasia, Histiocytic |             3                          3                                 |             
      Pancreatic, Hyperplasia, Lymphoid    |             4                                                        4   |             
      Pancreatic, Necrosis                 |             4                                                            |             
      Renal, Hyperplasia, Lymphoid         |             3     2                                                      |             
      Renal, Hyperplasia, Plasma Cell      |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             M                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |       2     3                                                            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    40.0                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Erythrocytic                     | 4  2     3        4                 3                                    |             
      Hyperplasia, Lymphoid                |          3                       2                       2               |             
      Red Pulp, Pigmentation               |                               3                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3           4                                                   |             
      Cyst                                 |          X                                X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    3  2  3        3                    1                             1   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Exudate                              |                                                                          |             
      Inflammation, Suppurative            |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |       2                    3     2  2     3              X               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                                   |             
      Mineralization                       |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Degeneration, Multifocal | 3                                                                        |             
      Cerebellum, Hemorrhage               | 3                                                                        |             
      Hippocampus, Necrosis                |          2                                                               |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                      2   |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |             3                                                            |             
      Thalamus, Degeneration               |          2                                                               |             
      Thalamus, Hemorrhage                 |          3                                                               |             
      Thalamus, Mineralization             |    3        1                       3           1  2  2  3  1     2  2  1|             
      Ventricle, Hydrocephalus             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                1         |             
      Inflammation, Chronic                |    2                       2           2        3        2  3  2        2|             
      Inflammation, Suppurative            |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 0| 0| 0| 3| 7| 2| 2| 2| 7| 0| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 7| 4| 6| 9| 9| 3| 2| 8| 9| 9| 8| 9| 9| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    40.0                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Artery, Mineralization               |                         2                                                |             
      Interstitium, Edema                  |                   2                       3                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                               3                             3            |             
      Fungus                               |                                                       3                  |             
      Hemorrhage                           |                                                                      2   |             
      Inflammation, Suppurative            | 2     3  4  3     3     4     3  2  4  4        3  4  3  3  4  3  4  3  4|             
      Submucosa, Hyperplasia, Lymphoid     |                                        3                       3         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Middle Ear, Inflammation, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts                                |       1  3  1           2        1                                       |             
      Inflammation, Chronic                |          2        2     2  2     3     2  3                 2     2  2  2|             
      Inflammation, Suppurative            |          1                                                               |             
      Metaplasia, Osseous                  |                                                                          |             
      Renal Tubule, Atrophy                |       2                                   2                              |             
      Renal Tubule, Regeneration           |          3           2                    1        1                     |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                          +               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2  2                 2           3           2  3  2  3        2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    40.0                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |                                           X                              |      1     |
      Infiltration Cellular, Lymphocyte    |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cecum, Mucosa, Necrosis              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Duodenum, Amyloid Deposition         |                   2                                                      |      1  2.0|
      Ileum, Amyloid Deposition            |                   4     2                                                |      3  3.3|
      Jejunum, Amyloid Deposition          |                   2                                                      |      2  2.0|
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |            |
           Lymphoid                        |       4                                4                                 |      3  3.3|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       4                                                                  |      1  4.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.7|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
      Inflammation, Chronic                |    2  3                    2        3                       2            |     13  2.5|
      Inflammation, Chronic Active         | 1                                                                        |      1  1.0|
      Bile Duct, Cyst                      |                X                                                         |      1     |
      Hepatocyte, Cytoplasmic Alteration   |                                                                          |      1  3.0|
      Hepatocyte, Karyomegaly              |                                                                          |      1  3.0|
      Hepatocyte, Necrosis                 |                                                                          |      5  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      4  2.3|
      Kupffer Cell, Hyperplasia            |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                   +                     |   7        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Fat, Inflammation, Chronic Active    |                                                                          |      1  3.0|
      Fat, Mineralization                  |                                                                          |      3  2.7|
      Fat, Necrosis, Focal                 |                2                                                         |      4  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |       1                                                                  |      1  1.0|
      Cytoplasmic Alteration               |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                2                       1     2  1              2         |      7  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    40.0                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Diverticulum            |                                                             X            |      1     |
      Forestomach, Foreign Body            |                                     2                                    |      1  2.0|
      Forestomach, Hyperplasia, Focal      |                                     3              2     2               |      5  2.2|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                     2                                    |      2  2.0|
      Forestomach, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                          2               |      2  3.0|
      Glandular, Atrophy                   |                                                                          |      1  3.0|
      Glandular, Inflammation, Suppurative |             2                                                            |      1  2.0|
      Glandular, Metaplasia, Squamous      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endocardium, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Myocardium, Inflammation, Chronic    |                                                                          |      1  2.0|
      Myocardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Myocardium, Mineralization           |                                                                          |      1  4.0|
      Ventricle, Embolus Bacterial         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cortex, Degeneration, Fatty          |                   2        2                                             |      2  2.0|
      Cortex, Necrosis                     |                                                                          |      1  2.0|
      Medulla, Angiectasis                 |             4                                                            |      1  4.0|
      Spindle Cell, Hyperplasia            | 2  3  3  3  2  3  3  2  2  2  2  2  2  2  3  2  3  2  2  2  3  2  3  2  3|     48  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                2        2     1        3                                 |      7  2.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +|  44        |
      Angiectasis                          |                      2                 2                          2      |      6  2.2|
      Pars Distalis, Angiectasis           |                                                       1                  |      2  1.5|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |       2  2                 3           1                       2         |     13  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    40.0                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Intermedia, Hyperplasia         |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                                                          2               |      2  2.0|
      Follicle, Dilatation                 |       4  3                       3  3  3  3                 3            |      8  3.1|
      Follicle, Hyperplasia                |       2                                                                  |      1  2.0|
      Follicular Cell, Hyperplasia         |    2     2                 3                          2                  |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |             2                                                            |      1  2.0|
      Angiectasis                          |                                                                          |      2  2.5|
      Cyst                                 | X           X  X  X  X                 X  X              X     X  X  X   |     19     |
      Hemorrhage                           |             4     3                                         2            |      7  2.9|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hydrometra                           |    3                                                                     |      1  3.0|
      Hyperplasia, Cystic                  | 4  3  3  3  3  2  2  3  3  3     2  3  3  3  2  3  4  3  2     2  3  3  4|     45  3.0|
      Hyperplasia, Glandular               |                                  2                                       |      2  2.5|
      Inflammation, Chronic                |                                  3                                       |      1  3.0|
      Inflammation, Suppurative            | 1                                2        2  2           2               |      7  2.4|
      Endometrium, Vacuolization           |                                                                          |            |
          Cytoplasmic                      |                                                                3         |      1  3.0|
      Mucosa, Metaplasia, Squamous         |                            2     2                                       |      2  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  3.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mandibular, Hyperplasia, Lymphoid    |       3     3                    3                          4            |      4  3.3|
      Mandibular, Hyperplasia, Plasma Cell |                                                             4            |      1  4.0|
      Mandibular, Necrosis, Diffuse        |                                                                          |      1  2.0|
      Mandibular, Pigmentation             |                                                                          |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    40.0                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  4.0|
      Mesenteric, Angiectasis              |                                                                          |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Mesenteric, Hemorrhage               |                                           2                       2      |      4  2.0|
      Mesenteric, Hyperplasia, Histiocytic |                                                                          |      2  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      2  4.0|
      Pancreatic, Necrosis                 |                                                                          |      1  4.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      2  2.5|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |             3                                4                           |      7  3.3|
      Hyperplasia, Lymphoid                |       3  3  3                    3                                       |      7  2.7|
      Red Pulp, Pigmentation               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|  45        |
      Atrophy                              |                                                                          |      2  3.5|
      Cyst                                 | X                                                                        |      3     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Cystic                  |                1        2     3                                          |      9  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |          1           2  1                                                |      3  1.3|
      Exudate                              |          1                                                               |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |       3        3  2        3           2           3              3  3   |     14  2.6|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebellum, Degeneration, Multifocal |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    40.0                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cerebellum, Hemorrhage               |                                                                          |      1  3.0|
      Hippocampus, Necrosis                |                                                                          |      1  2.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |          2                                                               |      2  2.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                                                                          |      1  3.0|
      Thalamus, Degeneration               |                                                                          |      1  2.0|
      Thalamus, Hemorrhage                 |                                                                          |      1  3.0|
      Thalamus, Mineralization             | 2                                   2              2  1  2           2  1|     18  1.8|
      Ventricle, Hydrocephalus             |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  45        |
      Degeneration                         |                            2                                             |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                   2                                                      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomatosis                         |                                           2                              |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                    3                     |      2  2.0|
      Inflammation, Chronic                |    2     2  2     2              2     2  4  2        3        2        2|     19  2.3|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
      Interstitium, Edema                  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Foreign Body                         |                                                                          |      2  3.0|
      Fungus                               |                                                                          |      1  3.0|
      Hemorrhage                           |          3     3                                                         |      3  2.7|
      Inflammation, Suppurative            | 3        3  3  4        3              3           3  3  3  3  3  3  3  3|     33  3.2|
      Submucosa, Hyperplasia, Lymphoid     |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                               +                             +            |   2        |
      Middle Ear, Inflammation, Suppurative|                               2                             4            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Casts                                |                                     1                                   1|      8  1.5|
      Inflammation, Chronic                |    2     2  2                    2  2  2  2  2  1     3  2  2  2     2  2|     26  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    40.0                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                                                          2               |      1  2.0|
      Renal Tubule, Atrophy                |       2     2                          2                                 |      5  2.0|
      Renal Tubule, Regeneration           |             1                    2                                       |      6  1.7|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |    2                                2                       2     2      |     13  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20.0                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Muscularis, Inflammation, Chronic    |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  I  +  +  +  +  +  A  A  +  +  +  +  M  +  +  +  +  M  +|             
      Infiltration Cellular, Lymphocyte    |                                                          2               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Jejunum, Fibrosis                    | 3                                                                        |             
      Jejunum, Inflammation, Suppurative   |                                                                          |             
      Jejunum, Necrosis                    | 3                                                                        |             
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |             
           Lymphoid                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |                                                             2            |             
      Inflammation, Chronic Active         |          2                       2                                       |             
      Inflammation, Suppurative            |                                                                          |             
      Hepatocyte, Karyomegaly              |                                                                      3   |             
      Hepatocyte, Necrosis                 |    2     1                                                           1  1|             
      Hepatocyte, Vacuolization Cytoplasmic|                                     2                       2            |             
      Kupffer Cell, Hyperplasia            |    3                                                                 2   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +                                                        +            |             
      Inflammation, Chronic                |                                                             3            |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |    4                                                                     |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      2                                      2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             2     1  2  2                                            2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Hyperplasia, Focal      |                                                 3                    1   |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |             3                                                            |             
      Forestomach, Mineralization          |                         2                                                |             
      Forestomach, Mucosa, Hyperplasia,    |                                                                          |             
           Focal                           |             3                                                            |             
      Glandular, Cyst                      |                                                                          |             
      Glandular, Hemorrhage                |                                                                          |             
      Glandular, Metaplasia, Squamous      |                                                                          |             
      Glandular, Mineralization            |                         2                                                |             
      Glandular, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20.0                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multiple                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           | X                                                                        |             
      Artery, Mineralization               |                                                                          |             
      Endocardium, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
          Active                           |       2                                                                  |             
      Pericardium, Inflammation, Chronic   |                                                                          |             
          Active                           |                3                                                         |             
      Valve, Inflammation, Suppurative     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Cortex, Degeneration, Fatty          |                                                             2            |             
      Cortex, Developmental Malformation   |                                                                         X|             
      Cortex, Hyperplasia, Focal           |                                                       2                  |             
      Cortex, Necrosis                     |    2                                                                     |             
      Cortex, Vacuolization Cytoplasmic    |                                                          2               |             
      Spindle Cell, Hyperplasia            |    3  2  3  2     3  2  2  2     3  2  2     3  3  3  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
      Cyst                                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      2   |             
      Pars Distalis, Hyperplasia           |                      2                       2           2              2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                             3        2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                         1                                                |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicle, Dilatation                 |    3        3           3  3                       3        2            |             
      Follicular Cell, Hyperplasia         |                      2                          2           3            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +              +                                          |             
      Foreign Body                         |                2              2                                          |             
      Hemorrhage                           |                               4                                          |             
      Inflammation, Chronic Active         |                4                                                         |             
      Inflammation, Suppurative            |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20.0                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Cyst                                 |       X     X  X                       X     X     X                     |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |    3                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                   2                                                      |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  | 3  3  2  3  3     3  3  2  4     3  2     2  2  3  3  3  4  3  3  3  4  3|             
      Inflammation, Suppurative            |    3  2                          1                 2                     |             
      Endometrium, Edema                   |                         2                                                |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                      +                                                   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  2        3                 2                                       |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Inflammation, Suppurative |    2                                                                     |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Mandibular, Hyperplasia, Histiocytic |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |             
      Mandibular, Pigmentation             | 2                                                                        |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
      Mediastinal, Hemorrhage              |    3                                                                     |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |    3                                                                     |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mesenteric, Hemorrhage               |                         3                                                |             
      Mesenteric, Hyperplasia, Histiocytic |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                 2        3               |             
      Mesenteric, Hyperplasia, Plasma Cell |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20.0                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |    2  2                                                                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                  2                 2        2     2      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                           3                          3   |             
      Hyperplasia, Megakaryocyte           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2           3                                                         |             
      Hyperplasia, Lymphoid                |                                                 3                        |             
      Mineralization                       |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                         2                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      2     1                                             |             
      Inflammation, Granulomatous          |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                   2  3     2                       2     2  2        2  3|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                         +               |             
      Inflammation, Chronic Active         |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Hemorrhage               |                                                                          |             
      Cerebrum, Hemorrhage                 |                                                                          |             
      Thalamus, Mineralization             | 1  2  2  1  1     1  2  2        2  1        1  2        1        3  2   |             
      Vein, Adventitia, Infiltration       |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             
      Ventricle, Mineralization            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                              1                           |             
      Infiltration Cellular, Lymphocyte    |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |    4                                                                     |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 7| 7| 7| 7| 0| 4| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 3| 3| 3| 0| 3| 3| 3| 3| 0| 4| 5| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 9| 1| 1| 1| 7| 1| 1| 1| 1| 2| 2| 1| 5| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20.0                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |          2  2        2  2  2     3     2  2     3           2  2     2   |             
      Inflammation, Suppurative            |    4                                                                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Inflammation, Suppurative    |    4                                                                     |             
      Pleura, Inflammation, Chronic        |                                                                          |             
      Pleura, Inflammation, Chronic Active |                3                                                         |             
      Pleura, Inflammation, Suppurative    |                               3                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                        3  3                              |             
      Fungus                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |       2  1        3     4              4  4  3  2  3        3  2     3  3|             
      Mucosa, Atrophy                      |                                                                          |             
      Mucosa, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +     +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts                                |             2     2  1  1  1           1        1     1                  |             
      Cyst                                 |             X                                                            |             
      Glomerulosclerosis                   |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |    3                                                                     |             
      Inflammation, Chronic                |          3  2        1  1              2  2  2  3  2        3  2     2   |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                         3                                2               |             
      Pigmentation                         |             3                                                            |             
      Glomerulus, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Mineralization         |                                                       1                  |             
      Renal Tubule, Regeneration           |    1                                               1                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  M  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  M  +  +  +|             
      Inflammation, Chronic                |             2        3  2        3              2                 2     3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3|            |
                                           | 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    20.0                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Muscularis, Inflammation, Chronic    |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  I  +  +  +  +  +  M  +  +  +|  41        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Jejunum, Fibrosis                    |                                                                          |      1  3.0|
      Jejunum, Inflammation, Suppurative   |                                                       3                  |      1  3.0|
      Jejunum, Necrosis                    |                                                                          |      1  3.0|
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |            |
           Lymphoid                        |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                   3     4                          4  2  4               |      5  3.4|
      Inflammation, Chronic                |       2              2           1     2                                 |      5  1.8|
      Inflammation, Chronic Active         |                            3                                             |      3  2.3|
      Inflammation, Suppurative            |                   4                                                      |      1  4.0|
      Hepatocyte, Karyomegaly              |                                                                          |      1  3.0|
      Hepatocyte, Necrosis                 |                         3  1                             4     2         |      8  1.9|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      2  2.0|
      Kupffer Cell, Hyperplasia            |                                     3                 2  3               |      5  2.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +        +  +                       +  +     +  +         |  10        |
      Inflammation, Chronic                |                         4                                                |      2  3.5|
      Inflammation, Chronic Active         |                                                             3            |      1  3.0|
      Inflammation, Suppurative            |                                                       4                  |      2  4.0|
      Fat, Necrosis, Focal                 |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                          2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |          2                                                               |      6  1.8|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Forestomach, Hyperplasia, Focal      |             3              3                             2              3|      6  2.5|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                            2                                             |      2  2.5|
      Forestomach, Mineralization          |                                                                          |      1  2.0|
      Forestomach, Mucosa, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Glandular, Cyst                      |                                  X                                   X   |      2     |
      Glandular, Hemorrhage                |                                                       3                  |      1  3.0|
      Glandular, Metaplasia, Squamous      |                                        2                                 |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3|            |
                                           | 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    20.0                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Glandular, Mineralization            |                                                                          |      1  2.0|
      Glandular, Necrosis                  |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                   +      |   1        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multiple                         |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           |                                                          X               |      2     |
      Artery, Mineralization               |                                                                   3      |      1  3.0|
      Endocardium, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                    2                     |      1  2.0|
      Myocardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                   2                                                      |      2  2.0|
      Pericardium, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Valve, Inflammation, Suppurative     |                                                          4               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                         3                                   3            |      2  3.0|
      Cortex, Degeneration, Fatty          |                            3                                             |      2  2.5|
      Cortex, Developmental Malformation   |                      X                             X                     |      3     |
      Cortex, Hyperplasia, Focal           |                                                                          |      1  2.0|
      Cortex, Necrosis                     |                                                                          |      1  2.0|
      Cortex, Vacuolization Cytoplasmic    |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            | 3  3  3  2  3     2  2  3  2  2  2  3  2  3        3  3  3  2  3  3  2  2|     43  2.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Cyst                                 |                                                                   X     X|      3     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|  45        |
      Angiectasis                          |                            2                                             |      2  2.0|
      Pars Distalis, Hyperplasia           |                   1  3           1     2  2                       3  2   |     11  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Lymphocyte    |    3                 2                                                   |      4  2.5|
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Ultimobranchial Cyst                 |                                                    X                     |      1     |
      Follicle, Dilatation                 |                                           3                             2|      8  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3|            |
                                           | 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    20.0                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Hyperplasia         |                      2                 3  2                              |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Foreign Body                         |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |    X  X  X  X        X     X              X                    X  X     X|     16     |
      Hemorrhage                           |                                                                         3|      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                   4     4                             4  4  4            |      5  4.0|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                      +   |   1        |
      Inflammation, Chronic                |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                   2      |      1  2.0|
      Hydrometra                           |                               2                                          |      1  2.0|
      Hyperplasia, Cystic                  | 3  3  3  4  3     2  2  2  2     3  2  2  2           3  2     2  4  2  2|     41  2.7|
      Inflammation, Suppurative            |                   3     3  2                       4  3  2  3        2  2|     13  2.5|
      Endometrium, Edema                   |                                                                          |      1  2.0|
      Mucosa, Metaplasia, Squamous         |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   3     4                          4  4  4  3            |     10  3.2|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bronchial, Inflammation, Suppurative |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Plasma Cell      |                         3                                3  3            |      3  3.0|
      Mandibular, Hyperplasia, Histiocytic |                                        2                                 |      1  2.0|
      Mandibular, Hyperplasia, Lymphoid    |                      3                                               2   |      2  2.5|
      Mandibular, Hyperplasia, Plasma Cell |                                                                      2   |      1  2.0|
      Mandibular, Pigmentation             |       3                                                                  |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3|            |
                                           | 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    20.0                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                         3                                                |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                       2                  |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                       2  3               |      2  2.5|
      Mediastinal, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                         4                                3               |      2  3.5|
      Mesenteric, Hemorrhage               |          2           2  2                                               2|      5  2.2|
      Mesenteric, Hyperplasia, Histiocytic |                                     4                                    |      1  4.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                           3                              |      3  2.7|
      Mesenteric, Hyperplasia, Plasma Cell |                                                       3                  |      1  3.0|
      Renal, Hyperplasia, Plasma Cell      |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                  2                                       |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |             3     3     4                             3  3  2            |      8  2.8|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |          2  3                                      4     3               |      8  2.5|
      Hemorrhage                           |                                  3                                       |      1  3.0|
      Hyperplasia, Lymphoid                |                      3                    3                              |      4  3.0|
      Hyperplasia, Megakaryocyte           |                                                                   3      |      1  3.0|
      Necrosis                             |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|  43        |
      Atrophy                              |                      3                                   2               |      4  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Cystic                  |    2     2              2           2                    2        1      |      7  1.9|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                                                          |      2  1.5|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |             3     2        3        2                 2  3              2|     15  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3|            |
                                           | 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    20.0                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebellum, Hemorrhage               |                                                                3         |      1  3.0|
      Cerebrum, Hemorrhage                 |                                                                3         |      1  3.0|
      Thalamus, Mineralization             |       2  1  3           3  3        1  2                 1        2  2   |     25  1.8|
      Vein, Adventitia, Infiltration       |                                                                          |            |
          Cellular, Lymphocyte             |                                                                      2   |      1  2.0|
      Ventricle, Mineralization            |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration                         |                         2                                                |      1  2.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                                                          |      1  4.0|
      Infiltration Cellular, Histiocyte    |    1           2                                                         |      2  1.5|
      Inflammation, Chronic                |    2     2  2        2                                            2      |     17  2.1|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                      3                                                   |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                    3                     |      1  3.0|
      Artery, Inflammation, Suppurative    |                                                                          |      1  4.0|
      Pleura, Inflammation, Chronic        |                                              2                           |      1  2.0|
      Pleura, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Pleura, Inflammation, Suppurative    |                                                 2                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +|  44        |
      Foreign Body                         | 3              3                                                         |      4  3.0|
      Fungus                               |                      3                                                   |      1  3.0|
      Inflammation, Chronic                |                                                                         3|      1  3.0|
      Inflammation, Suppurative            | 3  3  3     2  3     4  3  3        3  4           2     3  2     2  4  3|     29  2.9|
      Mucosa, Atrophy                      |                                                                         3|      1  3.0|
      Mucosa, Necrosis                     |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                                                                  |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| 0| 0| 6| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 6| 0| 3| 3| 0| 3| 6| 3| 3| 0| 0| 3| 6| 3| 1| 5| 3| 3| 3|            |
                                           | 9| 1| 1| 1| 1| 8| 9| 3| 1| 1| 1| 2| 7| 1| 2| 4| 6| 8| 7| 2| 1| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    20.0                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Casts                                |    1                                2                                    |     10  1.3|
      Cyst                                 |                                     X                                    |      2     |
      Glomerulosclerosis                   |                         2           2                                    |      2  2.0|
      Hydronephrosis                       |                                                          2               |      1  2.0|
      Infarct                              |                                                                      2   |      2  2.5|
      Inflammation, Chronic                | 2  2  2     3        3  2  2     2     2                 2  2        2   |     24  2.1|
      Inflammation, Suppurative            |                   3                                      2               |      2  2.5|
      Metaplasia, Osseous                  |                                        2                                 |      3  2.3|
      Pigmentation                         |                                                                          |      1  3.0|
      Glomerulus, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                          2               |      1  2.0|
      Renal Tubule, Atrophy                |                                                                         2|      1  2.0|
      Renal Tubule, Mineralization         |                                                       2                  |      2  1.5|
      Renal Tubule, Regeneration           |                         3           2                       2            |      5  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Chronic                |          2              2  2                             3  2     2      |     13  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  M  +  M  +  +  +  +  I  +  A  +  +  M  +  +  M  +  +|             
      Concretion                           |                                                    X                     |             
      Hemorrhage                           |                                     3                                    |             
      Inflammation, Suppurative            |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Hyperplasia, Lymphoid         |                                                                   3  3   |             
      Cecum, Mucosa, Fibrosis              |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |             
           Lymphoid                        |          2                                               3     2         |             
      Mucosa, Ileum, Dysplasia             |                                                                         3|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2                                                                  |             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |             3                                                            |             
      Hepatocyte, Anisokaryosis            |                                                                          |             
      Hepatocyte, Cytomegaly               | 2                                                                        |             
      Hepatocyte, Karyomegaly              |                                                                          |             
      Hepatocyte, Necrosis                 |                      4                                   3               |             
      Hepatocyte, Vacuolization Cytoplasmic| 3        2                                   3     3                 2   |             
      Kupffer Cell, Hyperplasia            | 3           3                                                            |             
      Kupffer Cell, Pigmentation           |                                           3                 3            |             
                                            __________________________________________________________________________|             
   Mesentery                               | +           +                 +  +                                       |             
      Inflammation, Suppurative            |                               3                                          |             
      Fat, Necrosis, Focal                 | 3                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Atypia Cellular, Focal               |                                                                          |             
      Inflammation, Chronic                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2     2                             2  2           2  1        3  2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Cyst                    |                                                                          |             
      Forestomach, Hyperplasia             | 3                                2              2           3            |             
      Forestomach, Inflammation, Chronic   |                                                 3           2            |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                  3                                       |             
      Forestomach, Mineralization          |                            2                                             |             
      Forestomach, Ulcer                   | 2                                               3                        |             
      Forestomach, Mucosa, Hyperplasia     |       2                                                                  |             
      Glandular, Cyst                      |                                                                          |             
      Glandular, Dysplasia                 |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Glandular, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
      Glandular, Inflammation, Suppurative |                                                                2         |             
      Glandular, Metaplasia, Squamous      |                                                                          |             
      Glandular, Mineralization            |          2                                                               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +     +        +     +         |             
      Developmental Malformation           |                                                 X        X     X         |             
      Peridontal Tissue, Fibrosis          |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                           3                              |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                              +                           |             
      Inflammation, Chronic Active         |                                              3                           |             
      Aorta, Embolus Bacterial             |                                                                          |             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus Bacterial                    |                                                                          |             
      Thrombosis                           |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Suppurative                      |                                                                          |             
      Coronary Artery, Necrosis, Fibrinoid |                                                                          |             
      Endocardium, Inflammation, Chronic   |                                                                          |             
      Epicardium, Fibrosis                 |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
      Myocardium, Fibrosis                 |                                                                          |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
      Myocardium, Inflammation, Suppurative|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                          X               |             
      Cortex, Hyperplasia, Focal           |                                                                         2|             
      Cortex, Hyperplasia                  |                                                             2            |             
      Cortex, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                       2                  |             
      Medulla, Hyperplasia                 |                                                                          |             
      Spindle Cell, Hyperplasia            |    2  2  2  2           2  2           2        2  2     2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                                                                          |             
      Hyperplasia                          |       2  2  3           2                                   3  3     4  3|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  I  +  +  +  M  M  M  M  M  M  +  +  +  +  +  M  M  +  M  M  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  M  +  M  +  +  +  +  +  M  M  +  M  M  +  +  +  I  +  +  +|             
      Pars Distalis, Cyst                  |                                     X                                X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                         1|             
      Follicle, Crystals                   |                                                                         2|             
      Follicle, Dilatation                 |                                                          2               |             
      Follicular Cell, Hyperplasia         |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                              +                           |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                              4                           |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                      +  M|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +                                +              +         |             
      Ectasia                              | 4  3  3     3                                   4                        |             
      Inflammation, Chronic                |    1     4  3                                   2                        |             
      Inflammation, Chronic Active         |                                                                4         |             
      Inflammation, Suppurative            |          3     3                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   3                                3              2      |             
      Inflammation, Suppurative            |                4              3     3              3                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                A  +     +                          +     +     +         |             
      Amyloid Deposition                   |                         3                                                |             
      Dilatation                           |                                                          3               |             
      Fibrosis                             |                   3     3                                                |             
      Inflammation, Chronic                |                                                    4                     |             
      Inflammation, Suppurative            |                   3                                3                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Mineralization               |             2                                                            |             
      Seminiferous Tubule, Atrophy         |                                                                3         |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   3      |             
      Hyperplasia, Histiocytic             |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                4  3           3                    2  3                 2|             
      Pigmentation                         |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
      Iliac, Hyperplasia, Plasma Cell      |                4                                                         |             
      Inguinal, Fibrosis                   |                                     2                                    |             
      Inguinal, Hyperplasia, Histiocytic   |          4                                                               |             
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |             
      Mesenteric, Atrophy                  |                   4                                                      |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mesenteric, Hemorrhage               |    2  2  2  2           3              2  2                 2     3      |             
      Mesenteric, Hyperplasia, Histiocytic |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                         3|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                      3              2                 3     2           2|             
      Hyperplasia, Lymphoid                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  M  +  +  +  +  M  M  +  M  +  +  +  M  +  M  +  +  M  +  M|             
      Cyst                                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    2                    3     2  2  2                                    |             
      Exudate                              |                               2                                          |             
      Fibrosis                             |                               3                                          |             
      Inflammation, Chronic                |                         3                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multiple                         |                                                             2            |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Proliferation                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                     +  +            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                          3               |             
      Inflammation, Suppurative            |    3                                                        3            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             | 2     3  1           2  1           3     3     2     2     2        1  3|             
      Venule, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  M  M  M  I  I  M  +  +  +  +  +  +  +  M  M  M  +  +  +  +|             
      Inflammation, Chronic                |                                                                2         |             
      Inflammation, Subacute               |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2                                            2           3               |             
      Inflammation, Chronic                |    2  2  2  2                          2  2  3              2  2  2  2   |             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                      X                                                   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Mineralization               |                      2                                                   |             
      Interstitium, Edema                  |                            2  2  2                                       |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |       3                                3           1     2  2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +           +         |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                   M                                                      |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Bacterium                            |                                                                          |             
      Calculus Micro Observation Only      |                               2                                          |             
      Casts                                |                      2                             4        3            |             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                | 2  2        1  3     3                             4     2  3  2  3  2   |             
      Inflammation, Suppurative            |                   4                                2                     |             
      Metaplasia, Osseous                  |                                                                          |             
      Renal Tubule, Atrophy                |                                                    4                     |             
      Renal Tubule, Degeneration           |                               3                                          |             
      Renal Tubule, Dilatation             |                   3           3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 0| 2| 5| 7| 7| 1| 6| 6| 7| 7| 4| 5| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 7| 1| 7| 3| 3| 0| 3| 9| 3| 3| 0| 2| 4| 3| 3| 9| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 0| 2| 9| 2| 2| 5| 4| 0| 2| 2| 2| 7| 1| 2| 2| 4| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Mineralization         |       1                                                                  |             
      Renal Tubule, Regeneration           |       1     1              1           2  1           1  1  3  2  3  1  1|             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                +              +                                          |             
      Angiectasis                          |                               4                                          |             
      Inflammation, Chronic Active         |                3                                                         |             
      Inflammation, Suppurative            |                               2                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             2            |             
      Calculus Gross Observation           |                   X                                                      |             
      Inflammation, Chronic                |                   4                                4                     |             
      Inflammation, Chronic Active         |                3                                                         |             
      Inflammation, Suppurative            |                   3                                                      |             
      Mucosa, Hyperplasia                  |                   3                                4                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Concretion                           |                                              X                           |      2     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cecum, Hyperplasia, Lymphoid         |                                                                          |      2  3.0|
      Cecum, Mucosa, Fibrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |            |
           Lymphoid                        |                                                                          |      3  2.3|
      Mucosa, Ileum, Dysplasia             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Clear Cell Focus                     |       X                             X                                    |      2     |
      Hematopoietic Cell Proliferation     |                      2                 2  4                              |      3  2.7|
      Inflammation, Chronic                |                                                                      3   |      2  3.0|
      Hepatocyte, Anisokaryosis            |          3                                                               |      1  3.0|
      Hepatocyte, Cytomegaly               |                      2                                                   |      2  2.0|
      Hepatocyte, Karyomegaly              |                      3                          3  2                     |      3  2.7|
      Hepatocyte, Necrosis                 |                                              4                           |      3  3.7|
      Hepatocyte, Vacuolization Cytoplasmic|                         1                                         2      |      7  2.3|
      Kupffer Cell, Hyperplasia            |                                                                      3   |      3  3.0|
      Kupffer Cell, Pigmentation           |                                                                      3   |      3  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   5        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            2                                             |      1  2.0|
      Atypia Cellular, Focal               |       2                                                                  |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    2  3     3                          2                                 |     13  2.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Cyst                    |                         X                                                |      1     |
      Forestomach, Hyperplasia             | 1     2     3              3                    3                    2   |     10  2.4|
      Forestomach, Inflammation, Chronic   |                                                                      2   |      3  2.3|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |             2              3                    3                        |      4  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Mineralization          |                                                                          |      1  2.0|
      Forestomach, Ulcer                   |                                                                          |      2  2.5|
      Forestomach, Mucosa, Hyperplasia     |                                                                          |      1  2.0|
      Glandular, Cyst                      |    X                                                                     |      1     |
      Glandular, Dysplasia                 |                                                 3                        |      2  2.5|
      Glandular, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                 2                        |      1  2.0|
      Glandular, Inflammation, Suppurative |       2        2                                                         |      3  2.0|
      Glandular, Metaplasia, Squamous      |                                                                2         |      1  2.0|
      Glandular, Mineralization            |    2                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                            +        +              +                     |   7        |
      Developmental Malformation           |                                                    X                     |      4     |
      Peridontal Tissue, Fibrosis          |                            3                                             |      1  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                     3                                    |      2  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                               +              +                           |   3        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Aorta, Embolus Bacterial             |                               X              X                           |      2     |
      Aorta, Inflammation, Chronic Active  |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Embolus Bacterial                    |                               X                                          |      1     |
      Thrombosis                           |                                                                         4|      1  4.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Suppurative                      |                                              4                           |      1  4.0|
      Coronary Artery, Necrosis, Fibrinoid |                                              4                           |      1  4.0|
      Endocardium, Inflammation, Chronic   |                                                          3               |      1  3.0|
      Epicardium, Fibrosis                 |                                                 2                        |      1  2.0|
      Epicardium, Inflammation, Chronic    |                                                 1                        |      1  1.0|
      Myocardium, Fibrosis                 |          2                                                               |      1  2.0|
      Myocardium, Inflammation, Chronic    |                                                          3               |      1  3.0|
      Myocardium, Inflammation, Suppurative|                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Developmental Malformation           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cortex, Hyperplasia, Focal           |                2                                                         |      2  2.0|
      Cortex, Hyperplasia                  |                                                                          |      1  2.0|
      Cortex, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Medulla, Hyperplasia                 |          3  2                                                            |      2  2.5|
      Spindle Cell, Hyperplasia            |       3     2     2  2  2        2  2  2  2        2  2  2     2         |     27  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia                            |                                                       2                  |      1  2.0|
      Hyperplasia                          | 2                 3              3                 3     2        3     2|     15  2.7|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  M  +  +  M  M  M  I  +  +  +  +  +  +  +  +  M  M|  28        |
      Infiltration Cellular, Lymphocyte    |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  40        |
      Pars Distalis, Cyst                  |                                     X                                    |      3     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|  45        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Follicle, Crystals                   |                                                                          |      1  2.0|
      Follicle, Dilatation                 |                   3                                3           3     3   |      5  2.8|
      Follicular Cell, Hyperplasia         |                                        2           2                 2   |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                             +            |   2        |
      Foreign Body                         |                                                             2            |      1  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                    +                     |   2        |
      Dilatation                           |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +  +     +              +  +           +  +  +  M     +  +  +  +|  20        |
      Ectasia                              |          4  4                    3  3           4  3  3        3  4      |     14  3.4|
      Inflammation, Chronic                |          2  3                    2                             3  2  4   |     10  2.6|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation, Suppurative            |          3        3                             2  4              3  4  4|      9  3.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic                |             2     2                    2                          2      |      7  2.3|
      Inflammation, Suppurative            |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Dilatation                           |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Mineralization               |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         |    3                                                                    1|      3  2.3|
      Seminiferous Tubule, Mineralization  |                      2              2  1                                2|      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia                          |    2                 2                    4                              |      9  2.8|
      Pigmentation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  4.0|
      Inguinal, Fibrosis                   |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Histiocytic   |                            2                                             |      2  3.0|
      Mandibular, Hyperplasia, Plasma Cell |                                           3                              |      1  3.0|
      Mesenteric, Atrophy                  |                                                                          |      1  4.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                   2  2                 3  3                              |      4  2.5|
      Mesenteric, Hemorrhage               |          3        3           3  3  2           2     3           2  3  3|     19  2.5|
      Mesenteric, Hyperplasia, Histiocytic |                                                 3                        |      1  3.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                        4  3                              |      2  3.5|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                      3     2                    3                    2  2|     10  2.4|
      Hyperplasia, Lymphoid                |                            3                                             |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  M  +  +  M|  35        |
      Cyst                                 |                                                    X                 X   |      3     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |    2  3           2                 2  3                       2        3|     12  2.3|
      Exudate                              |                                                                          |      1  2.0|
      Fibrosis                             |                   2                 2                                    |      3  2.3|
      Inflammation, Chronic                |       2                             3  2                                 |      4  2.5|
      Inflammation, Chronic Active         |                                  3                                       |      1  3.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multiple                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                        3                                 |      1  3.0|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                         3|      1  3.0|
      Proliferation                        |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                               +                  |   5        |
      Inflammation, Chronic                |       2                                               2                  |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thalamus, Mineralization             |             1                 1     2        2  2                 2  2  2|     20  2.0|
      Venule, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                                                1         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Subacute               |          3     2                                   2                     |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |                                                                          |      3  2.3|
      Inflammation, Chronic                |    2  1  2  3  3  3  1  2        2     2        2     2  2     2  2  2   |     27  2.1|
      Inflammation, Suppurative            |                                                                2         |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |      1  2.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
      Interstitium, Edema                  |             2                                                            |      4  2.0|
      Pleura, Inflammation, Suppurative    |                                                             3            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
      Inflammation, Chronic                |                                                                3         |      1  3.0|
      Inflammation, Suppurative            |       3  3        3        3        2  3        3     2  2     3        3|     16  2.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +        +  +                    +                              |   6        |
      Inflammation, Chronic                |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                          +               |   1        |
      Inflammation, Chronic                |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |          2                                                               |      1  2.0|
      Bacterium                            |                               3                                          |      1  3.0|
      Calculus Micro Observation Only      |                                                                          |      1  2.0|
      Casts                                |          3                                                              3|      5  3.0|
      Cyst                                 |                   X                                               X     X|      3     |
      Infarct                              |                                                                2         |      1  2.0|
      Inflammation, Chronic                |    3  2  4  2  2  3     2  2  3     1  3        3  2  1  2     2     2  3|     29  2.4|
      Inflammation, Suppurative            |                               3                                          |      3  3.0|
      Metaplasia, Osseous                  | 1                                                                        |      1  1.0|
      Renal Tubule, Atrophy                |          2                                                               |      2  3.0|
      Renal Tubule, Degeneration           |                                                                          |      1  3.0|
      Renal Tubule, Dilatation             |                                                                          |      2  3.0|
      Renal Tubule, Mineralization         |                1                                                         |      2  1.0|
      Renal Tubule, Regeneration           |             1  2        1  1     1  1     2        1  1  1     1  2  1  3|     26  1.4|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
      Angiectasis                          |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Calculus Gross Observation           |                                                                          |      1     |
      Inflammation, Chronic                |    2        2                                                            |      4  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20.0                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  M  M  +  +  M  +  +  +  +  A  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Serosa, Ectopic Tissue        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |             
           Lymphoid                        |                                  2                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |       X                                            X                     |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                      3                                                   |             
      Hyperplasia, Focal                   |                                           2                              |             
      Inflammation, Chronic                | 3                                                        2     2         |             
      Mineralization                       |                                                                          |             
      Hepatocyte, Karyomegaly              |                                                                          |             
      Hepatocyte, Necrosis                 | 3                             3                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|             2                    2              3     2           2     1|             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Vein, Thrombosis                     |                                                                          |             
      Vein, Adventitia, Fibrosis           |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +        +                       +                    +|             
      Fibrosis                             |                                                                         3|             
      Mineralization                       |                                                                         3|             
      Artery, Inflammation, Chronic        |                                                    3                     |             
      Fat, Necrosis, Focal                 |                            4                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  I  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2  2                 2                       2                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Hyperplasia             |                         3                 3                       2      |             
      Forestomach, Inflammation, Chronic   |                                           2                              |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Glandular, Cyst                      |    X                                                                     |             
      Glandular, Mineralization            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                     +        +      |             
      Developmental Malformation           |    X                                                     X               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
      Inflammation, Chronic Active         |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20.0                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |    X                                                  X                  |             
      Cortex, Atrophy                      |                                                                          |             
      Cortex, Hyperplasia, Focal           |                                                                          |             
      Medulla, Hyperplasia                 |                                                                          |             
      Spindle Cell, Hyperplasia            |    2  2  2                       2  2  2              2  2        2     2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  4     3        3     2                             3               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Crystals                             |                                        3                                 |             
      Cyst                                 |                                        X                                 |             
      Infiltration Cellular, Lymphocyte    |          2                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |          2                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Follicle, Dilatation                 |                      2                          4                        |             
      Follicular Cell, Hyperplasia         |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +  +     +              +  +                    +               |             
      Ectasia                              |             3                    2  2                    3               |             
      Inflammation, Chronic                |             2                    3  3                    3               |             
      Inflammation, Suppurative            |          3        3                                      3               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +                                      +                       +|             
      Dilatation                           |                                                                          |             
      Fibrosis                             |                                                 3                       3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20.0                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                         2|             
      Inflammation, Chronic Active         |                                                 3                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                                          |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          4           4                                      4            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Histiocytic   |                                                                      3   |             
      Inguinal, Hyperplasia, Plasma Cell   |                      3                                                   |             
      Inguinal, Pigmentation               |             2                                               3            |             
      Lymphatic, Mandibular, Ectasia       |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mandibular, Hyperplasia, Plasma Cell |    3                       3                                             |             
      Mesenteric, Angiectasis              |             4                                                            |             
      Mesenteric, Atrophy                  |                                                                          |             
      Mesenteric, Congestion               | 3                                                                        |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |    2                             2                 3                     |             
      Mesenteric, Hemorrhage               |    2  2     4  3                 2                                3      |             
      Mesenteric, Hyperplasia, Histiocytic |          3                                                               |             
      Mesenteric, Hyperplasia, Lymphoid    | 3                                                                        |             
      Mesenteric, Hyperplasia, Plasma Cell |                      3                                                   |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Mast Cell                       |                                                                   2      |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Megakaryocyte                   | 3                                                                        |             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |          3        4  4                                                   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     | 3                                                  3  2        3         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Necrosis, Focal                      |                         4                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  I  +  M  M  +  +  M  +  +  +  +  +  +  M  M  +  +  +  M  M  +  +|             
      Cyst                                 |       X     X                       X                 X                 X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20.0                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Acanthosis                           |    1              2                                3           3  3      |             
      Edema                                |                                                                          |             
      Erosion                              |                                                             3  3         |             
      Exudate                              |                                                                          |             
      Fibrosis                             |                      4                                                   |             
      Foreign Body                         |                            3                                             |             
      Fungus                               |                                                                          |             
      Hyperkeratosis                       |                2                                                         |             
      Inflammation, Chronic                |                                                                3  2      |             
      Inflammation, Chronic Active         |                      4                                                   |             
      Inflammation, Granulomatous          |                            3                                             |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                   2  4                                                   |             
      Sebaceous Gland, Hyperplasia         |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                          2               |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Vacuolization Cytoplasmic  |                                                                          |             
      Hippocampus, Infiltration Cellular,  |                                                                          |             
           Lymphocyte                      |                      1                                                   |             
      Thalamus, Mineralization             |    2                 2  2                 2           2  3     2     2  1|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Degeneration                         |                                                                          |             
      Inflammation, Chronic                |                                                    4                     |             
      Inflammation, Subacute               |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                3         |             
      Infiltration Cellular, Eosinophil    |                                                                          |             
      Infiltration Cellular, Histiocyte    |    3                                   3                                 |             
      Inflammation, Chronic                |       2  2  2                    2                       2           2   |             
      Inflammation, Suppurative            |       2  2                                            2     2        2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 2| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 0| 7| 3| 6| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 7| 2| 2| 2|             
                                           | 4| 9| 9| 9| 9| 5| 9| 7| 8| 9| 5| 9| 9| 9| 9| 2| 9| 9| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20.0                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                               X                                          |             
      Bronchus, Foreign Body               |                                                                          |             
      Capillary, Infiltration Cellular,    |                                                                          |             
           Polymorphonuclear               |                                                                          |             
      Interstitium, Edema                  |                                              2     3                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Fungus                               |                                           3                              |             
      Inflammation, Suppurative            |    3  1                 3           2  3  3                              |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Submucosa, Cyst                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
      Cornea, Hyperplasia                  |          3                                                               |             
      Cornea, Inflammation, Chronic Active |          3                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +  +        +     +        +                                       |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Casts                                | 2              2        1              2                                 |             
      Cyst                                 |                            X                                            X|             
      Glomerulosclerosis                   | 2                                                                        |             
      Hydronephrosis                       |                                                             2            |             
      Infarct                              |                                                       2                  |             
      Inflammation, Chronic                | 2  4  2  2     3     2           1  2  1  2        2     2     2  2  2   |             
      Inflammation, Suppurative            |                                                             2        1   |             
      Cortex, Necrosis                     |                                                                          |             
      Renal Tubule, Atrophy                |    4                                      2                              |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Regeneration           | 1     1     1  2                 1  2  2  3        1  1     2     1  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                             X            |             
      Fibrosis                             |                                                             3            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                  2              2                        |             
      Inflammation, Suppurative            |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2|            |
                                           | 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    20.0                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  M  +  +  +  M  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  M|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cecum, Serosa, Ectopic Tissue        |             X                                                            |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |            |
           Lymphoid                        |    3                                                           2         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                        2                                 |      1  2.0|
      Clear Cell Focus                     |                                                                          |      2     |
      Eosinophilic Focus                   |                                        X                                 |      1     |
      Hematopoietic Cell Proliferation     | 2                                3                 2                     |      4  2.5|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                    3     2               |      5  2.4|
      Mineralization                       |                         4                                                |      1  4.0|
      Hepatocyte, Karyomegaly              |                               2  2                                       |      2  2.0|
      Hepatocyte, Necrosis                 |                                  4                                       |      3  3.3|
      Hepatocyte, Vacuolization Cytoplasmic|    2  2                 2                       3                        |     10  2.1|
      Kupffer Cell, Hyperplasia            |                                                                         X|      1     |
      Kupffer Cell, Pigmentation           |                         4                                                |      1  4.0|
      Vein, Thrombosis                     |                                                          3               |      1  3.0|
      Vein, Adventitia, Fibrosis           |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                         +        +                 +   |   8        |
      Fibrosis                             |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                                           3                          3   |      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                                     2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    2  2                             2                 3                  |      8  2.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Hyperplasia             |             2              1                       2  2           2  3   |      9  2.2|
      Forestomach, Inflammation, Chronic   |                                                                          |      1  2.0|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                   2  2   |      2  2.0|
      Glandular, Cyst                      |                                                                          |      1     |
      Glandular, Mineralization            |             3                          2  2                              |      3  2.3|
                                            __________________________________________________________________________|____________|
   Tooth                                   |             +                                                            |   4        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2|            |
                                           | 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    20.0                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Developmental Malformation           |             X                                                            |      3     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                           2                              |      1  2.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Developmental Malformation           |                                                                          |      2     |
      Cortex, Atrophy                      |                                                                3         |      1  3.0|
      Cortex, Hyperplasia, Focal           |                                        2                                 |      1  2.0|
      Medulla, Hyperplasia                 |                3                       3                                 |      2  3.0|
      Spindle Cell, Hyperplasia            |          2     2        2           3  3  3        2     2     2  2     2|     21  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |             3                                                            |      7  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +|  43        |
      Crystals                             |                                                                          |      1  3.0|
      Cyst                                 |                                                                   X      |      2     |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  I  M  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M|  40        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Mineralization                       |             1                                                            |      1  1.0|
      Follicle, Dilatation                 | 3                                                                        |      3  3.0|
      Follicular Cell, Hyperplasia         |                         2                                                |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |             +                                                            |   1        |
      Dilatation                           |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                 2                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2|            |
                                           | 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    20.0                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +           +  +                 M  +                    +         |  11        |
      Ectasia                              |                                                                2         |      5  2.4|
      Inflammation, Chronic                |       4              3                    2                              |      7  2.9|
      Inflammation, Suppurative            |                   4  2                                                   |      5  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |       2     2                                                            |      2  2.0|
      Inflammation, Suppurative            |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +     +                                                      |   5        |
      Dilatation                           |             4                                                            |      1  4.0|
      Fibrosis                             |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Seminiferous Tubule, Atrophy         |                                                                2  2      |      2  2.0|
      Seminiferous Tubule, Mineralization  |       2                                                        3  2      |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3           2                 2  3  3        3              4            |     10  3.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Histiocytic   |                      3                                                   |      2  3.0|
      Inguinal, Hyperplasia, Plasma Cell   |                               3                                          |      2  3.0|
      Inguinal, Pigmentation               | 3              3                                                         |      4  2.8|
      Lymphatic, Mandibular, Ectasia       |                                              3                           |      1  3.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                 3                        |      1  3.0|
      Mandibular, Hyperplasia, Plasma Cell |             3                 3                             3            |      5  3.0|
      Mesenteric, Angiectasis              |                                                                          |      1  4.0|
      Mesenteric, Atrophy                  |                   3                                                      |      1  3.0|
      Mesenteric, Congestion               |                                                                          |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                  3                                       |      4  2.5|
      Mesenteric, Hemorrhage               |    2     3  4     3     3  2  4                                3         |     14  2.9|
      Mesenteric, Hyperplasia, Histiocytic |                                                                          |      1  3.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                     4     4                              |      3  3.7|
      Mesenteric, Hyperplasia, Plasma Cell |                                                                          |      1  3.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Mast Cell                       |                                                                          |      1  2.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Megakaryocyte                   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2|            |
                                           | 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    20.0                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Hyperplasia, Histiocytic      |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                        4                    3            |      5  3.6|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |          2        3                          2  3  4                     |      9  2.8|
      Hyperplasia, Lymphoid                |                                           3                              |      1  3.0|
      Hyperplasia, Plasma Cell             |                               3                                          |      1  3.0|
      Necrosis, Focal                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +|  36        |
      Cyst                                 |                                     X                    X               |      7     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                   X  3  3     3           2  4     1  3  2  3  2     3   |     18  2.5|
      Edema                                |                                              3                           |      1  3.0|
      Erosion                              |                                                                          |      2  3.0|
      Exudate                              |                                                             2        2   |      2  2.0|
      Fibrosis                             |                                                                          |      1  4.0|
      Foreign Body                         |                                                                          |      1  3.0|
      Fungus                               |                4                                                         |      1  4.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic                |                   2     2     3                                2     3   |      7  2.4|
      Inflammation, Chronic Active         |          2              3                                                |      3  3.0|
      Inflammation, Granulomatous          |                4                                                         |      2  3.5|
      Inflammation, Suppurative            |                                                          4               |      1  4.0|
      Ulcer                                |                      3  2     X              3                           |      6  2.8|
      Sebaceous Gland, Hyperplasia         |                                                                      2   |      1  2.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +  +  +|  47        |
      Necrosis                             |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                              +              +           +|   4        |
      Foreign Body                         |                                                                         2|      1  2.0|
      Hemorrhage                           |                                                             3            |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                         3|      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2|            |
                                           | 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    20.0                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                             3            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebrum, Vacuolization Cytoplasmic  |                                                                         3|      1  3.0|
      Hippocampus, Infiltration Cellular,  |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
      Thalamus, Mineralization             | 2        2  2           3  2  3     3  2  2        2  2  3  2  1     2  4|     25  2.2|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  M  +  +  +  +  +|  42        |
      Degeneration                         |                         2                                                |      1  2.0|
      Inflammation, Chronic                |                      1                                                   |      2  2.5|
      Inflammation, Subacute               |                                                                         2|      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                  3        3                              |      3  3.0|
      Infiltration Cellular, Eosinophil    |                                     2                                    |      1  2.0|
      Infiltration Cellular, Histiocyte    |    2                          3                                2         |      5  2.6|
      Inflammation, Chronic                | 2     2  1     2        2           2        2        3  2     2        2|     17  2.0|
      Inflammation, Suppurative            |          1              2                 2                             2|      9  1.9|
      Thrombosis                           |                                                                          |      1     |
      Bronchus, Foreign Body               |                                           2                              |      1  2.0|
      Capillary, Infiltration Cellular,    |                                                                          |            |
           Polymorphonuclear               |                               4                                          |      1  4.0|
      Interstitium, Edema                  |                                              2                           |      3  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Fungus                               |                                                    3                     |      2  3.0|
      Inflammation, Suppurative            |       3  3     3              4        3  3        3  3        2     3   |     16  2.8|
      Mucosa, Metaplasia, Squamous         |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                           3                              |      1  3.0|
      Submucosa, Cyst                      | X                                                                        |      1     |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                M                                                         |   1        |
      Cornea, Hyperplasia                  |                                                                          |      1  3.0|
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +           +                    +                     |   8        |
      Cyst                                 |                               X                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 2| 2| 2| 7| 7| 2| 2| 2| 7| 1| 2| 2| 2| 2| 3| 7| 2| 2| 6| 3| 4| 2| 2|            |
                                           | 8| 9| 9| 9| 7| 8| 8| 9| 9| 9| 3| 9| 9| 9| 9| 2| 3| 8| 9| 9| 6| 5| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    20.0                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                  4                                       |      1  4.0|
      Casts                                |                                                                   1      |      5  1.6|
      Cyst                                 |                                                                          |      2     |
      Glomerulosclerosis                   |                   1                                               2      |      3  1.7|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Chronic                | 2     3              2     2  2                       2  2     2  2  3  3|     26  2.2|
      Inflammation, Suppurative            |                                  4                                       |      3  2.3|
      Cortex, Necrosis                     |                                  4                                       |      1  4.0|
      Renal Tubule, Atrophy                |                                                       2  2               |      4  2.5|
      Renal Tubule, Mineralization         |             4                                                            |      1  4.0|
      Renal Tubule, Regeneration           |    1  1                 1              1  1           1           1     1|     22  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Calculus Micro Observation Only      |             X                                                            |      2     |
      Fibrosis                             |                                                                          |      1  3.0|
      Hemorrhage                           |             3                                                            |      1  3.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|             
                                           | 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10.0                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  M  M  +  +  +  +  M  +  +  A  +  +  +  +  +  +  M  M  +  +  M  I  +  +|             
      Amyloid Deposition                   |             3                                                            |             
      Inflammation, Suppurative            |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duodenum, Ulcer                      |                                                                          |             
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |             
           Lymphoid                        |                                                                         2|             
      Serosa, Jejunum, Cyst                |          X                                                               |             
      Serosa, Jejunum, Inflammation,       |                                                                          |             
          Granulomatous                    |          3                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |             3                                                     2      |             
      Inflammation, Chronic Active         |                         1                                                |             
      Bile Duct, Cyst                      |                                                                   X      |             
      Hepatocyte, Cytoplasmic Alteration   |    2     2                                                               |             
      Hepatocyte, Karyomegaly              |                                                 3                        |             
      Hepatocyte, Necrosis                 | 1                             4                    4                     |             
      Hepatocyte, Vacuolization Cytoplasmic|          2     3                    3                                    |             
      Kupffer Cell, Hyperplasia            |                                  3        3                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                                                                   3      |             
      Artery, Necrosis                     |                                                                          |             
      Artery, Thrombosis                   |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                   3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |                                                                      4   |             
      Cyst                                 |             X                                                        X   |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |                                  2                                   2   |             
      Inflammation, Suppurative            |                                                                      2   |             
      Artery, Inflammation, Chronic        |             2                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       1                             2                          2         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Hyperplasia             |                            2                                         2   |             
      Forestomach, Inflammation, Chronic   |                                                                      2   |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Forestomach, Inflammation,           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|             
                                           | 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10.0                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Suppurative                      |                                                                          |             
      Forestomach, Mineralization          |                                                                          |             
      Glandular, Erosion                   |                                                    2                     |             
      Glandular, Inflammation, Suppurative |             2                                                            |             
      Glandular, Mineralization            |       2                    2                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +  +  +                          +  +                             +  +|             
      Developmental Malformation           |    X  X  X                          X  X                             X  X|             
      Foreign Body                         |    3                                                                     |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |    3                                                                     |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                        3                             3   |             
      Pulp, Inflammation, Suppurative      |          3                             3                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |             2                                                            |             
      Myocardium, Inflammation, Chronic    |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Cortex, Hyperplasia, Focal           |                         2                                                |             
      Cortex, Vacuolization Cytoplasmic    |    2                    2                                                |             
      Medulla, Hyperplasia                 |                                  2                                       |             
      Spindle Cell, Hyperplasia            |    2  1     2        2  2  2        2  2  3           2     2           2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |       2  2                          3  2                          2     3|             
      Infiltration Cellular, Lymphocyte    |                                  3                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | I  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                        X     X                           |             
      Pars Distalis, Hyperplasia           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Dilatation                 |    3                                                           2     3   |             
      Follicular Cell, Hyperplasia         | 3                                      2                 2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|             
                                           | 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10.0                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   3      |             
      Inflammation, Granulomatous          |                                                          3               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +        +           +                          +           +  +|             
      Ectasia                              |       2  3        3           3                          3           3  2|             
      Inflammation, Chronic                |       3  3        3                                      3              2|             
      Inflammation, Suppurative            |                                                          3               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                       3                  |             
      Inflammation, Chronic                |                            2                          4     3            |             
      Inflammation, Suppurative            |                                                       4     3            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                           +           +     +            |             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |                                                       4     3            |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                                          |             
      Seminiferous Tubule, Mineralization  |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                     +                                    |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                             4     2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Histiocytic   |                            4                                             |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                                                                          |             
      Inguinal, Pigmentation               |                                  3                                       |             
      Mandibular, Hyperplasia, Lymphoid    |                                     3                                    |             
      Mandibular, Hyperplasia, Plasma Cell |                                                          3               |             
      Mandibular, Pigmentation             |                                                    3                     |             
      Mesenteric, Angiectasis              |                                  3                                       |             
      Mesenteric, Atrophy                  |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                     3                       3            |             
      Mesenteric, Hemorrhage               |       2     3        4                 3  4              2  2  3     2  4|             
      Mesenteric, Hyperplasia, Plasma Cell |                                                       2                  |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Polymorphonuclear               |                                           3                              |             
      Mesenteric, Lymphatic, Ectasia       |                                                             2            |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
      Renal, Lymphatic, Ectasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|             
                                           | 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10.0                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     | 2                                         2                 3            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |             2     3           3     3                 3                  |             
      Hyperplasia, Lymphoid                |                                  2  2                                    |             
      Hyperplasia, Megakaryocyte           |                                           3                              |             
      Lymphoid Follicle, Atrophy           |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  M  +  M  +  M  +  M  M  M  +  M  +  +  +  +  +|             
      Atrophy                              |                                                             3            |             
      Cyst                                 |    X                                X                 X              X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Acanthosis                           |                   3  2     3  2        3        2              3     3   |             
      Acanthosis, Multiple                 |                                                                          |             
      Edema                                |                               3                                         3|             
      Exudate                              |                                                                      2   |             
      Fibrosis                             |                            2                    3                        |             
      Fungus                               |                                                                          |             
      Inflammation, Chronic                |                      2                 2                       2         |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                            3                                             |             
      Inflammation, Suppurative            |                            3                    3                        |             
      Ulcer                                |                   3                                                      |             
      Lymphatic, Angiectasis               |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                         3                                            3   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
      Inflammation, Chronic                |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             | 2  2     3  1        2  2  2     3     2              2  3  2  1     2   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |    3                 4                    2           2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 5| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 1| 5| 8| 6| 3| 7| 2| 3| 3| 3|             
                                           | 1| 0| 0| 0| 0| 4| 8| 0| 0| 0| 4| 0| 0| 0| 8| 1| 9| 9| 8| 0| 2| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10.0                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |       2     1        3        2     3                                    |             
      Inflammation, Suppurative            |       2              3                                                   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Glands, Ectasia                      |                                                                          |             
      Interstitium, Edema                  |                               2                    2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                        2  2                              |             
      Glands, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts                                |    3        2  1                 2        2     3                        |             
      Congestion                           |                                                                          |             
      Cyst                                 |       X     X           X                             X  X     X         |             
      Glomerulosclerosis                   |    2                             2              1                        |             
      Hydronephrosis                       |                                                       2                  |             
      Inflammation, Chronic                |    3        3  1        2  1  2     2                 4  2     2        1|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                             2            |             
      Metaplasia, Osseous                  |                                                                          |             
      Renal Tubule, Atrophy                |             2                                         3                  |             
      Renal Tubule, Mineralization         |       1                                                                  |             
      Renal Tubule, Regeneration           |    3  1  1              1        3  1  1        3        2        1     1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               3                                          |             
      Inflammation, Chronic                | 2                                2                    3                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Mucosa, Hyperplasia                  |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2|            |
                                           | 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10.0                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  I  +  +  +|  35        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duodenum, Ulcer                      |                3                                                         |      1  3.0|
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |            |
           Lymphoid                        |          3                                                               |      2  2.5|
      Serosa, Jejunum, Cyst                |                                                                          |      1     |
      Serosa, Jejunum, Inflammation,       |                                                                          |            |
          Granulomatous                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                                     X                                    |      1     |
      Hematopoietic Cell Proliferation     |                      2                       2              4            |      3  2.7|
      Inflammation, Chronic                |                   2                                                      |      3  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Hepatocyte, Cytoplasmic Alteration   |                                                                          |      2  2.0|
      Hepatocyte, Karyomegaly              |                               2                                          |      2  2.5|
      Hepatocyte, Necrosis                 |                                                             4            |      4  3.3|
      Hepatocyte, Vacuolization Cytoplasmic|          2  1                                      1                     |      6  2.0|
      Kupffer Cell, Hyperplasia            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +     +           +                    +           +|   6        |
      Hemorrhage                           |                                                                         4|      1  4.0|
      Mineralization                       |                                                                          |      1  3.0|
      Artery, Necrosis                     |                      3                                                   |      1  3.0|
      Artery, Thrombosis                   |                                                                         X|      1     |
      Fat, Necrosis, Focal                 |                            3           4                                 |      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      2     |
      Hyperplasia, Focal                   |                                  3                                       |      1  3.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                               1  2  3              2              3      |      8  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2|            |
                                           | 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10.0                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Hyperplasia             |             3                    3                                3      |      5  2.6|
      Forestomach, Inflammation, Chronic   |                                                                          |      1  2.0|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                   3     2|      2  2.5|
      Forestomach, Inflammation,           |                                                                          |            |
          Suppurative                      |                                  3                                       |      1  3.0|
      Forestomach, Mineralization          |             3                                                            |      1  3.0|
      Glandular, Erosion                   |    2                                                                     |      2  2.0|
      Glandular, Inflammation, Suppurative |                                                          2               |      2  2.0|
      Glandular, Mineralization            |                                           2                              |      3  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                            +                                         +  +|  10        |
      Developmental Malformation           |                            X                                         X  X|     10     |
      Foreign Body                         |                                                                          |      1  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  3.0|
      Pulp, Inflammation, Suppurative      |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                               2                                          |      2  2.0|
      Myocardium, Inflammation, Chronic    |                                                             2            |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Developmental Malformation           |                                                                      X   |      1     |
      Cortex, Hyperplasia, Focal           |       2  2                          2                                    |      4  2.0|
      Cortex, Vacuolization Cytoplasmic    |                                                                          |      2  2.0|
      Medulla, Hyperplasia                 |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            |       2  2  2        1        2  2  2  2  2  3  2  2              2  2  2|     27  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |    3  2     4        2     4                                   2     2   |     13  2.5|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  I  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  M|  40        |
      Cyst                                 |                                     X                                    |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  I  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  44        |
      Pars Distalis, Cyst                  |                         X                                      X         |      4     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2|            |
                                           | 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10.0                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia           |                                                                3         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Dilatation                 |                                                                          |      3  2.7|
      Follicular Cell, Hyperplasia         |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                   +                                               +      |   2        |
      Hemorrhage                           |                                                                   4      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +        +           +     +     +                                   +  +|  14        |
      Ectasia                              | 3        4                       3                                   3  4|     12  3.0|
      Inflammation, Chronic                |                            4                                             |      6  3.0|
      Inflammation, Suppurative            |                      4     4                                             |      3  3.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                      4                                                   |      4  3.3|
      Inflammation, Suppurative            |                      4                                                   |      3  3.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                      +                          +                        |   5        |
      Fibrosis                             |                                                 3                        |      1  3.0|
      Inflammation, Suppurative            |                      4                                                   |      3  3.7|
      Pigmentation                         |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Seminiferous Tubule, Atrophy         |       2     3  2     2                             1           2        2|      7  2.0|
      Seminiferous Tubule, Mineralization  |                      2                          1        2               |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      4        3                                3        2|      7  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Inguinal, Hyperplasia, Histiocytic   |                                                                          |      1  4.0|
      Inguinal, Hyperplasia, Plasma Cell   |                               3                                          |      1  3.0|
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                                                                   3      |      1  3.0|
      Inguinal, Pigmentation               | 3  3                             3                                       |      4  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2|            |
                                           | 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10.0                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Mandibular, Hyperplasia, Plasma Cell |                3                                                         |      2  3.0|
      Mandibular, Pigmentation             |                      3                                                   |      2  3.0|
      Mesenteric, Angiectasis              |                                                 3                        |      2  3.0|
      Mesenteric, Atrophy                  |    3                                                                     |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                3     4        3                             3            |      6  3.2|
      Mesenteric, Hemorrhage               |                         2           2  4           2                     |     14  2.8|
      Mesenteric, Hyperplasia, Plasma Cell |                                                                          |      1  2.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Polymorphonuclear               |                                                                          |      1  3.0|
      Mesenteric, Lymphatic, Ectasia       |                                        3                                 |      2  2.5|
      Renal, Hemorrhage                    |                      3                                                   |      1  3.0|
      Renal, Hyperplasia, Plasma Cell      |                      3                                                   |      1  3.0|
      Renal, Lymphatic, Ectasia            |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                      3                                                   |      4  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                3              3           3           3        3         |     10  2.9|
      Hyperplasia, Lymphoid                |                                              3                           |      3  2.3|
      Hyperplasia, Megakaryocyte           |                                                                          |      1  3.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  M  M  +  M  M  +  M  +|  32        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |          X                 X              X                              |      7     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                   2  3        3     3        X  2  2     2               |     16  2.5|
      Acanthosis, Multiple                 |                                           3                              |      1  3.0|
      Edema                                |                                                    3                     |      3  3.0|
      Exudate                              |                                                                          |      1  2.0|
      Fibrosis                             |                   2                                                      |      3  2.3|
      Fungus                               |                   4                                                      |      1  4.0|
      Inflammation, Chronic                |                      2        3     2           1                        |      7  2.0|
      Inflammation, Chronic Active         |                                              3                           |      1  3.0|
      Inflammation, Granulomatous          |                   4                                                      |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2|            |
                                           | 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10.0                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                         2                                                |      4  2.5|
      Ulcer                                |                                           3                              |      3  2.7|
      Lymphatic, Angiectasis               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia                            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thalamus, Mineralization             |             2        1  3        2     2        2     2  2  2  2  2  3   |     26  2.1|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                        2                                 |      1  2.0|
      Infiltration Cellular, Histiocyte    |       4  2              2                                      2         |      8  2.6|
      Inflammation, Chronic                |                                     2  1           2     2              2|     10  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |             2           1     2        2                                 |      4  1.8|
      Glands, Ectasia                      |                                                          3               |      1  3.0|
      Interstitium, Edema                  |                2                                            2            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 2              2                                                        3|      5  2.2|
      Glands, Cyst                         |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                 +                        |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Casts                                |    3           4                                1     1        1         |     11  2.1|
      Congestion                           |                                                                3         |      1  3.0|
      Cyst                                 |                X                    X                                    |      8     |
      Glomerulosclerosis                   |                3                                                         |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05049-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 12:38:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 1| 1| 3| 3| 7| 4| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 2| 6| 3| 3| 2|            |
                                           | 6| 6| 4| 1| 1| 8| 5| 4| 1| 1| 7| 1| 1| 1| 1| 6| 4| 1| 1| 1| 4| 9| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    10.0                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic                |    3     1  2  4     2  1  2  1  1  3  1        1           3     2  1  2|     27  2.0|
      Inflammation, Chronic Active         |                                                                3         |      1  3.0|
      Inflammation, Suppurative            |                      3                                                   |      2  2.5|
      Metaplasia, Osseous                  |    2                          2                                          |      2  2.0|
      Renal Tubule, Atrophy                |          2                                                        2      |      4  2.3|
      Renal Tubule, Mineralization         |                                  1                                   1   |      3  1.0|
      Renal Tubule, Regeneration           |    3     2     4  2     1  1     2        1     1     1        3  2  1   |     24  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                              3                           |      4  2.5|
      Inflammation, Chronic Active         |                      3                                                   |      1  3.0|
      Mineralization                       |                                                       1                  |      1  1.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 624785-624785/624785


--multipart-boundary--