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TDMS Study 05049-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Southern Research Inst                                    DATE: 09/07/94   
EXP: 05049                       DICHLORVOS                    TIME: 05:51:43   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 00113B   
CONT: N01-ES-28024                                             CAS: 62-73-7     
PATHOLOGIST: J. HEATH                        S. EUSTIS                          
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Southern Research Inst                                    DATE: 09/07/94  
EXP: 05049                       DICHLORVOS                    TIME: 05:51:43  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 00113B  
CONT: N01-ES-28024                                             CAS: 62-73-7    
PATHOLOGIST: J. HEATH                        S. EUSTIS                         

                                    DICHLORVOS


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 1    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      70    105   212   402   527   541   543   550   579   585                 |
 |      590   634   690   694                                                     |
 |  CENSORED DEATHS                                                               |
 |      8                                                                         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10.0    MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      511   514   534   551   556   559   578   589   616   616                 |
 |      624   637   638   645   668   669   672   694   694   714                 |
 |      724   727   728                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 20.0    MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      2     210   422   466   505   533   565   573   578   578                 |
 |      578   578   578   579   619   634   635   637   640   668                 |
 |      727                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                    DICHLORVOS


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |    98.0  95.9  93.9  93.9  91.8  91.8  85.7  77.6  75.5  71.4      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |10.0       |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  84.0  72.0  54.0      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |20.0       |    98.0  98.0  96.0  96.0  94.0  92.0  88.0  72.0  62.0  58.0      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          10.0             20.0          |
 |                                CONTROL          MG/KG            MG/KG         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       71.4%            54.0%            58.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.218          P=0.206          P=0.266       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       480.1            628.6            538.3         |
 |NATURAL DEATHS (C)      |       (54.9)           (14.5)           (35.3)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       644.9            682.8            648.9         |
 |(STANDARD ERROR)        |       (25.4)           ( 9.7)           (19.9)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                    DICHLORVOS


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 6    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      427   452   568   579   582   601   602   611   625   633                 |
 |      646   668   669   693   706   707   709   724                             |
 |  CENSORED DEATHS                                                               |
 |      7     8     9     9     9     10                                          |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 20.0    MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 5    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      442   511   551   568   575   576   589   590   632   638                 |
 |      656   667   667   669   699   703                                         |
 |  CENSORED DEATHS                                                               |
 |      1     2     4     6     7                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 40.0    MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 2    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      368   520   534   623   624   634   640   654   656   672                 |
 |      676   708   709   709                                                     |
 |  CENSORED DEATHS                                                               |
 |      7     8                                                                   |
 |                                                                                |
 ==================================================================================

                                    DICHLORVOS


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0 100.0  95.5  95.5  84.1  75.0  59.1      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |20.0       |   100.0 100.0 100.0 100.0 100.0  97.8  95.6  82.2  75.6  64.4      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |40.0       |   100.0 100.0 100.0 100.0  97.9  97.9  93.8  93.8  81.3  70.8      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          20.0             40.0          |
 |                                CONTROL          MG/KG            MG/KG         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       59.1%            64.4%            70.8%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.271N         P=0.840N         P=0.296N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       622.3            608.3            623.4         |
 |NATURAL DEATHS (C)      |       (19.5)           (17.8)           (24.9)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       604.2            617.9            670.6         |
 |(STANDARD ERROR)        |       (32.9)           (30.8)           (21.6)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                             DICHLORVOS
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        10.0    MG/KG    = 2
                                                        20.0    MG/KG    = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 13         1                                                                    2
      |
      |  3         1     1               3                                              22
      |                  1               31                                3             2   2
   95 +
      |                                   1                             1  3      3          2 2
      |                                                                           3     3      22
      |                                                                 1                   1
   90 +                                                                                 3   131
      |
      |                                                                                      3  23 2
      |                                                                                       11 332  2
P  85 +
E     |                                                                                        1  31  2  2
R     |
C     |                                                                                            11
E  80 +                                                                                             1 1  2 2
N     |
T     |                                                                                               1    21
      |                                                                                                     22
S  75 +                                                                                                     1        1
U     |                                                                                                      22      11
R     |                                                                                            3      3   2   2
V     |                                                                                                               1     1
I  70 +                                                                                                   3 3
V     |
A     |
L     |                                                                                                           2   2
   65 +
      |                                                                                                     33
      |                                                                                                      3    3   2 2
      |
   60 +                                                                                                           3     2 2
      |
      |                                                                                                                   3 3
      |
   55 +
      |                                                                                                                   2 2
      |
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 5 obs hidden.

                                                             DICHLORVOS
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        20.0    MG/KG    = 2
                                                        40.0    MG/KG    = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                         3        1  2
      |
      |                                                           3        1  2 1       2  3
      |                                                                                    3 3
   95 +                                                                         1       2      2  1
      |                                                                                      3 2  11      3
      |
      |                                                                                           211     33
   90 +                                                                                                    33
      |                                                                                             1  1
P     |                                                                                                     33
E     |                                                                                            2  2
R  85 +                                                                                                      3 3
C     |                                                                                                1 1
E     |                                                                                               2     2
N     |                                                                                                  1 1   3  3
T  80 +                                                                                                    112
      |                                                                                                           33
S     |                                                                                                     1212   3    3
U     |
R  75 +                                                                                                       12  1
V     |
I     |
V     |                                                                                                                 3   3
A  70 +                                                                                                           1  1
L     |                                                                                                           2  121
      |
      |                                                                                                               22
   65 +                                                                                                                2    2
      |                                                                                                                11
      |
      |                                                                                                                 1 1
   60 +
      |                                                                                                                   1 1
      |
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 6 obs hidden.

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