TDMS Study 05049-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/07/94
EXP: 05049 DICHLORVOS TIME: 03:06:51
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 00113B
CONT: N01-ES-28024 CAS: 62-73-7
PATHOLOGIST: J. HEATH S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/07/94
EXP: 05049 DICHLORVOS TIME: 03:06:51
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 00113B
CONT: N01-ES-28024 CAS: 62-73-7
PATHOLOGIST: J. HEATH S. EUSTIS
DICHLORVOS
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 1 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 393 522 576 587 587 595 606 646 651 653 |
| 657 674 705 715 719 719 727 728 |
| CENSORED DEATHS |
| 617 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 4.0 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 5 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 426 477 533 561 586 634 644 645 645 653 |
| 658 664 677 679 684 688 691 695 695 698 |
| CENSORED DEATHS |
| 404 468 513 607 618 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 8.0 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 4 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 564 574 592 610 621 623 623 623 638 652 |
| 660 667 667 674 692 695 700 702 714 717 |
| 719 727 |
| CENSORED DEATHS |
| 461 462 470 692 |
| |
==================================================================================
DICHLORVOS
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 98.0 98.0 96.0 88.0 77.8 63.5 |
|CONTROL | |
| | |
|4.0 | 100.0 100.0 100.0 100.0 100.0 95.9 93.7 89.5 73.8 55.9 |
|MG/KG | |
| | |
|8.0 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.6 76.6 52.7 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 4.0 8.0 |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 63.5% 55.9% 52.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.368 P=0.524 P=0.401 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 636.7 631.7 657.0 |
|NATURAL DEATHS (C) | (20.4) (17.2) (10.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 693.5 669.4 680.7 |
|(STANDARD ERROR) | ( 9.7) (12.3) (10.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DICHLORVOS
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 1 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 404 532 547 582 596 602 622 646 651 677 |
| 691 692 695 702 711 711 714 714 |
| CENSORED DEATHS |
| 708 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 4.0 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 98 355 446 519 545 556 565 596 618 638 |
| 656 656 684 695 698 701 704 706 708 709 |
| 709 709 721 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 8.0 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 383 421 486 546 557 567 582 587 609 611 |
| 630 631 631 642 652 672 677 677 678 721 |
| 721 721 727 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DICHLORVOS
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 98.0 98.0 96.0 88.0 82.0 63.8 |
|CONTROL | |
| | |
|4.0 | 100.0 98.0 98.0 96.0 96.0 94.0 90.0 84.0 76.0 52.0 |
|MG/KG | |
| | |
|8.0 | 100.0 100.0 100.0 100.0 96.0 96.0 94.0 84.0 70.0 52.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 4.0 8.0 |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 63.8% 52.0% 52.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.239 P=0.309 P=0.276 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 638.3 613.3 619.0 |
|NATURAL DEATHS (C) | (19.6) (29.7) (18.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 695.9 673.5 676.2 |
|(STANDARD ERROR) | ( 9.3) (16.4) (11.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DICHLORVOS
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
4.0 MG/KG = 2
8.0 MG/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
|
| 1 2 2 1 33
| 2 1 2 31 3
95 +
| 2 2 11 3 3
|
| 2 2 33
90 + 1 1 2
|
| 1 1 22
| 1 1
P 85 + 22
E |
R | 3 311
C | 3 3
E 80 + 22
N | 3 3
T | 1 1
| 2 231 1
S 75 +
U | 2 2 1 1
R | 33
V |
I 70 + 3 3
V | 22
A | 223 11
L |
65 +
| 33 1 1
| 22
| 33
60 +
| 33
|
| 2 2
55 + 33
|
| 3 3
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
DICHLORVOS
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
4.0 MG/KG = 2
8.0 MG/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
|
| 2 2 3 1 3 1
| 2 3 2 3 1 1
95 +
| 2 3 2 31 1
| 2 2 3 1 1
|
90 + 2 23
|
| 22 3 1 1
| 2 2 1 1
P 85 +
E | 3 23 2
R | 332 21 1
C |
E 80 + 3 3 2 2 1 1
N |
T | 33
| 2 211
S 75 +
U | 33 2 11
R | 3 3 11
V |
I 70 + 3 3 22
V |
A | 33
L |
65 +
| 21 1
| 3 3
|
60 +
|
|
| 223
55 +
| 22
| 2 2
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.
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