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TDMS Study 05049-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Southern Research Inst                                    DATE: 09/07/94   
EXP: 05049                       DICHLORVOS                    TIME: 03:06:51   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 00113B   
CONT: N01-ES-28024                                             CAS: 62-73-7     
PATHOLOGIST: J. HEATH                        S. EUSTIS                          
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Southern Research Inst                                    DATE: 09/07/94  
EXP: 05049                       DICHLORVOS                    TIME: 03:06:51  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 00113B  
CONT: N01-ES-28024                                             CAS: 62-73-7    
PATHOLOGIST: J. HEATH                        S. EUSTIS                         

                                    DICHLORVOS


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 1    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      393   522   576   587   587   595   606   646   651   653                 |
 |      657   674   705   715   719   719   727   728                             |
 |  CENSORED DEATHS                                                               |
 |      617                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 4.0     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 5    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      426   477   533   561   586   634   644   645   645   653                 |
 |      658   664   677   679   684   688   691   695   695   698                 |
 |  CENSORED DEATHS                                                               |
 |      404   468   513   607   618                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 8.0     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 4    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      564   574   592   610   621   623   623   623   638   652                 |
 |      660   667   667   674   692   695   700   702   714   717                 |
 |      719   727                                                                 |
 |  CENSORED DEATHS                                                               |
 |      461   462   470   692                                                     |
 |                                                                                |
 ==================================================================================

                                    DICHLORVOS


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0  98.0  98.0  96.0  88.0  77.8  63.5      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |4.0        |   100.0 100.0 100.0 100.0 100.0  95.9  93.7  89.5  73.8  55.9      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |8.0        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  93.6  76.6  52.7      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          4.0              8.0           |
 |                                CONTROL          MG/KG            MG/KG         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       63.5%            55.9%            52.7%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.368          P=0.524          P=0.401       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       636.7            631.7            657.0         |
 |NATURAL DEATHS (C)      |       (20.4)           (17.2)           (10.4)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       693.5            669.4            680.7         |
 |(STANDARD ERROR)        |       ( 9.7)           (12.3)           (10.3)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                    DICHLORVOS


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 1    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      404   532   547   582   596   602   622   646   651   677                 |
 |      691   692   695   702   711   711   714   714                             |
 |  CENSORED DEATHS                                                               |
 |      708                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 4.0     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      98    355   446   519   545   556   565   596   618   638                 |
 |      656   656   684   695   698   701   704   706   708   709                 |
 |      709   709   721   728                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 8.0     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      383   421   486   546   557   567   582   587   609   611                 |
 |      630   631   631   642   652   672   677   677   678   721                 |
 |      721   721   727   727                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                    DICHLORVOS


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0  98.0  98.0  96.0  88.0  82.0  63.8      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |4.0        |   100.0  98.0  98.0  96.0  96.0  94.0  90.0  84.0  76.0  52.0      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |8.0        |   100.0 100.0 100.0 100.0  96.0  96.0  94.0  84.0  70.0  52.0      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          4.0              8.0           |
 |                                CONTROL          MG/KG            MG/KG         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       63.8%            52.0%            52.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.239          P=0.309          P=0.276       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       638.3            613.3            619.0         |
 |NATURAL DEATHS (C)      |       (19.6)           (29.7)           (18.9)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       695.9            673.5            676.2         |
 |(STANDARD ERROR)        |       ( 9.3)           (16.4)           (11.9)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                             DICHLORVOS
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        4.0     MG/KG    = 2
                                                        8.0     MG/KG    = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                              1   2                     3
      |
      |                                                                1   2        2      1     33
      |                                                                             2      1 2    31  3
   95 +
      |                                                                                      2   2 11 3  3
      |
      |                                                                                          2  2    33
   90 +                                                                                             1 1     2
      |
      |                                                                                               1 1   22
      |                                                                                                 1     1
P  85 +                                                                                                      22
E     |
R     |                                                                                                   3  311
C     |                                                                                                      3 3
E  80 +                                                                                                       22
N     |                                                                                                        3 3
T     |                                                                                                        1   1
      |                                                                                                        2 231   1
S  75 +
U     |                                                                                                          2 2   1 1
R     |                                                                                                           33
V     |
I  70 +                                                                                                            3 3
V     |                                                                                                            22
A     |                                                                                                             223  11
L     |
   65 +
      |                                                                                                               33  1 1
      |                                                                                                              22
      |                                                                                                                33
   60 +
      |                                                                                                                 33
      |
      |                                                                                                               2     2
   55 +                                                                                                                  33
      |
      |                                                                                                                   3 3
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 5 obs hidden.

                                                             DICHLORVOS
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        4.0     MG/KG    = 2
                                                        8.0     MG/KG    = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1              2                                             3  1
      |
      |                2                                        2    3  1  3                1
      |                                                         2          3  2      3      1  1
   95 +
      |                                                                       2      3     2  31    1
      |                                                                                    2  2 3   1  1
      |
   90 +                                                                                       2 23
      |
      |                                                                                         22  3  1  1
      |                                                                                          2     2  1   1
P  85 +
E     |                                                                                             3  23 2
R     |                                                                                                 332  21    1
C     |
E  80 +                                                                                                  3 3 2 2   1 1
N     |
T     |                                                                                                    33
      |                                                                                                        2    211
S  75 +
U     |                                                                                                     33      2 11
R     |                                                                                                      3 3       11
V     |
I  70 +                                                                                                        3  3   22
V     |
A     |                                                                                                           33
L     |
   65 +
      |                                                                                                                21   1
      |                                                                                                            3     3
      |
   60 +
      |
      |
      |                                                                                                                 223
   55 +
      |                                                                                                                  22
      |                                                                                                                   2 2
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 10 obs hidden.

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