Share This:
https://ntp.niehs.nih.gov/go/1819

TDMS Study 05053-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                             BROMOFORM


NTP Experiment-Test: 05053-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: GAVAGE                                                                                                     Time: 02:48:02




       Facility:  TSI Mason Research

       Chemical CAS #:  75-25-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05053-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           12           11                                                  
    Natural Death                                     14           23           19                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           13           20                                                  
    Natural Death                                                   2                                                               
  Culled                                               1                                                                            
  Animals Examined Microscopically                    49           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (38)         (16)         (37)                                                
   Intestine Large                                    (48)         (24)         (49)                                                
   Intestine Small                                    (47)         (22)         (48)                                                
   Liver                                              (49)         (50)         (50)                                                
      Hemangiosarcoma                                                            2 (4%)                                             
      Hepatocellular Carcinoma                         1 (2%)                    2 (4%)                                             
      Hepatocellular Adenoma                           1 (2%)       5 (10%)      3 (6%)                                             
      Hepatocellular Adenoma, Multiple                 2 (4%)       1 (2%)       1 (2%)                                             
      Hepatocholangiocarcinoma, Multiple               1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Mesentery                                          (16)         (19)         (19)                                                
   Pancreas                                           (46)         (26)         (47)                                                
   Salivary Glands                                    (46)         (24)         (45)                                                
   Stomach                                            (47)         (48)         (50)                                                
      Forestomach, Squamous Cell Papilloma                                       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (48)         (26)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (26)         (46)                                                
   Islets, Pancreatic                                 (46)         (25)         (47)                                                
      Adenoma                                                       1 (4%)                                                          
   Pituitary Gland                                    (44)         (27)         (46)                                                
      Pars Distalis, Adenoma                           7 (16%)      6 (22%)      5 (11%)                                            
      Pars Distalis, Adenoma, Multiple                                           1 (2%)                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 05053-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (49)         (49)         (47)                                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (45)         (36)         (49)                                                
   Uterus                                             (49)         (39)         (49)                                                
      Histiocytic Sarcoma                                           1 (3%)                                                          
      Leiomyosarcoma                                   1 (2%)                                                                       
      Polyp Stromal                                    1 (2%)       1 (3%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (25)         (50)                                                
   Lymph Node                                         (44)         (32)         (45)                                                
   Spleen                                             (48)         (35)         (50)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
   Thymus                                             (37)         (14)         (35)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (40)         (25)         (44)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (25)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05053-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (27)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)       1 (4%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Osteosarcoma, Metastatic                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (2)                                                              
      Adenoma                                                       1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (32)         (50)                                                
      Osteosarcoma, Metastatic                                                   1 (2%)                                             
   Urinary Bladder                                    (47)         (17)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(49)        *(50)        *(50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Lymphoma Malignant Histiocytic                   1 (2%)                    1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   4 (8%)       1 (2%)                                                          
      Lymphoma Malignant Mixed                         3 (6%)       2 (4%)       2 (4%)                                             
      Lymphoma Malignant Undifferentiated Cell         3 (6%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05053-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            24          18          18                                                   
     Total Primary Neoplasms                           30          22          25                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 11          13          15                                                   
     Total Benign Neoplasms                            15          16          17                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              15           6           8                                                   
     Total Malignant Neoplasms                         15           6           8                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      1                                                   
     Total Metastatic Neoplasm                                                  2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05053-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      .05 G/KG     0.1 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      4            7           10                                                  
    Moribund Sacrifice                                 5            6            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           37           36                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (6)          (30)                                                
   Intestine Small                                    (50)         (6)          (46)                                                
      Hepatocholangiocarcinoma, Metastatic             1 (2%)                                                                       
      Polyp Adenomatous                                1 (2%)                                                                       
   Liver                                              (50)         (50)         (49)                                                
      Hemangioma                                       1 (2%)       1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                                                          
      Hemangiosarcoma, Multiple                        1 (2%)                    2 (4%)                                             
      Hepatocellular Carcinoma                         5 (10%)      6 (12%)      6 (12%)                                            
      Hepatocellular Carcinoma, Multiple               2 (4%)       2 (4%)                                                          
      Hepatocellular Adenoma                          10 (20%)      9 (18%)      8 (16%)                                            
      Hepatocellular Adenoma, Multiple                 1 (2%)       2 (4%)                                                          
      Hepatocholangiocarcinoma                         1 (2%)                                                                       
      Osteosarcoma, Metastatic                                      1 (2%)                                                          
   Pancreas                                           (49)         (9)          (48)                                                
   Stomach                                            (50)         (50)         (49)                                                
      Forestomach, Squamous Cell Papilloma                          4 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (9)          (49)                                                
      Osteosarcoma, Metastatic                                      1 (11%)                                                         
      Capsule, Adenoma                                 1 (2%)       1 (11%)      1 (2%)                                             
      Medulla, Pheochromocytoma Benign                 1 (2%)                                                                       
   Thyroid Gland                                      (48)         (6)          (46)                                                
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   6                                                               
NTP Experiment-Test: 05053-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      .05 G/KG     0.1 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (6)          (48)                                                
   Lymph Node                                         (47)         (15)         (43)                                                
      Mediastinal, Hepatocholangiocarcinoma,                                                                                        
          Metastatic                                   1 (2%)                                                                       
   Spleen                                             (50)         (18)         (49)                                                
      Hemangioma                                       1 (2%)                                                                       
   Thymus                                             (35)         (6)          (30)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (1)                                                                           
      Adenoma                                          1 (100%)                                                                     
   Skin                                               (48)         (23)         (49)                                                
      Subcutaneous Tissue, Fibroma                     3 (6%)       5 (22%)      2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       7 (30%)      4 (8%)                                             
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Neurofibrosarcoma           1 (2%)       1 (4%)                                                          
      Subcutaneous Tissue, Sarcoma                                  1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05053-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      .05 G/KG     0.1 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)                                                
      Alveolar/Bronchiolar Adenoma                    10 (20%)      5 (10%)      2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       2 (4%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic             2 (4%)       3 (6%)       2 (4%)                                             
      Hepatocholangiocarcinoma, Metastatic             1 (2%)                                                                       
      Osteosarcoma, Metastatic                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (2)          (3)                                                 
      Adenoma                                          2 (100%)     1 (50%)      1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (20)         (49)                                                
      Hepatocholangiocarcinoma, Metastatic             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant                                                         1 (2%)                                             
      Lymphoma Malignant Histiocytic                   1 (2%)                    1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   1 (2%)                    2 (4%)                                             
      Lymphoma Malignant Mixed                         1 (2%)                                                                       
      Lymphoma Malignant Undifferentiated Cell         3 (6%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   8                                                               
NTP Experiment-Test: 05053-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      .05 G/KG     0.1 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            34          33          27                                                   
     Total Primary Neoplasms                           52          49          32                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 25          24          13                                                   
     Total Benign Neoplasms                            33          28          15                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          20          15                                                   
     Total Malignant Neoplasms                         19          21          17                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           5           2                                                   
     Total Metastatic Neoplasm                          6           7           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   9                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------