National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1831

TDMS Study 05053-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                             BROMOFORM


NTP Experiment-Test: 05053-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: GAVAGE                                                                                                     Time: 01:04:23




       Facility:  TSI Mason Research

       Chemical CAS #:  75-25-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05053-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:04:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      3            6            2                                                  
    Moribund Sacrifice                                13           16           19                                                  
    Gavage Death                                                                 1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           28           28                                                  
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (48)         (18)         (49)                                                
      Adenocarcinoma                                                             2 (4%)                                             
      Polyp Adenomatous                                             1 (6%)       6 (12%)                                            
   Intestine Small                                    (48)         (16)         (49)                                                
   Liver                                              (50)         (49)         (50)                                                
      Neoplastic Nodule                                             4 (8%)       1 (2%)                                             
      Neoplastic Nodule, Multiple                                                1 (2%)                                             
   Pancreas                                           (48)         (49)         (50)                                                
      Acinus, Adenoma                                  1 (2%)                    2 (4%)                                             
      Acinus, Adenoma, Multiple                                                  1 (2%)                                             
      Acinus, Carcinoma                                             1 (2%)                                                          
   Salivary Glands                                    (49)         (49)         (50)                                                
   Stomach                                            (50)         (26)         (50)                                                
      Forestomach, Squamous Cell Papilloma             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (16)         (50)                                                
      Pericardium, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (18)         (50)                                                
      Medulla, Pheochromocytoma Benign                 2 (4%)                    3 (6%)                                             
   Islets, Pancreatic                                 (48)         (49)         (50)                                                
      Adenoma                                          2 (4%)                                                                       
   Pituitary Gland                                    (48)         (46)         (48)                                                
      Pars Distalis, Adenoma                          26 (54%)     10 (22%)     16 (33%)                                            
                                                             Page   2                                                               
NTP Experiment-Test: 05053-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:04:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenoma, Multiple                 3 (6%)       2 (4%)                                                          
   Thyroid Gland                                      (50)         (47)         (49)                                                
      C-Cell, Adenoma                                  4 (8%)       3 (6%)       2 (4%)                                             
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       2 (4%)                                             
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (34)         (9)          (39)                                                
      Adenoma                                                       1 (11%)      2 (5%)                                             
      Carcinoma                                        1 (3%)       1 (11%)                                                         
   Ovary                                              (50)         (20)         (50)                                                
      Granulosa Cell Tumor                                          1 (5%)       1 (2%)                                             
   Uterus                                             (49)         (50)         (50)                                                
      Leiomyosarcoma                                   1 (2%)                                                                       
      Polyp Stromal                                    9 (18%)      9 (18%)      2 (4%)                                             
      Polyp Stromal, Multiple                          1 (2%)                                                                       
      Sarcoma Stromal                                  1 (2%)                                                                       
   Vagina                                                          (2)                                                              
      Squamous Cell Carcinoma                                       1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (16)         (50)                                                
   Lymph Node                                         (50)         (47)         (49)                                                
   Spleen                                             (49)         (28)         (50)                                                
   Thymus                                             (48)         (14)         (48)                                                
      Epithelial Cell, Thymoma NOS                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (42)         (39)                                                
      Adenocarcinoma, Multiple                         1 (2%)                                                                       
      Fibroadenoma                                    14 (32%)     16 (38%)      6 (15%)                                            
      Fibroadenoma, Multiple                           8 (18%)      1 (2%)                                                          
   Skin                                               (50)         (46)         (50)                                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05053-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:04:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (17)         (50)                                                
      Astrocytoma Malignant                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (32)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)       1 (3%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)                                             
      Carcinoma, Metastatic, Clitoral Gland                         1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Sarcoma                                                                    1 (2%)                                             
      Pelvis, Transitional Epithelium, Papilloma                                 1 (2%)                                             
      Renal Tubule, Adenoma                                                      1 (2%)                                             
   Urinary Bladder                                    (45)         (14)         (46)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                             9 (18%)     13 (26%)      6 (12%)                                            
      Lymphoma Malignant Histiocytic                   1 (2%)                                                                       
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05053-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:04:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          37          38                                                   
     Total Primary Neoplasms                           93          68          60                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          28          33                                                   
     Total Benign Neoplasms                            74          49          47                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          18          10                                                   
     Total Malignant Neoplasms                         18          18          12                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           1                                                   
     Total Metastatic Neoplasm                                      1           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1           1                                                   
     Total Uncertain Neoplasms                          1           1           1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05053-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:04:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      9            3            6                                                  
    Moribund Sacrifice                                 7           17           33                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           30           11                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (50)         (50)         (50)                                                
      Adenocarcinoma                                                             1 (2%)                                             
      Polyp Adenomatous                                                          2 (4%)                                             
   Intestine Small                                    (49)         (50)         (50)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Carcinoma                         1 (2%)                    1 (2%)                                             
      Neoplastic Nodule                                4 (8%)       2 (4%)                                                          
   Mesentery                                          (4)          (4)          (3)                                                 
   Pancreas                                           (50)         (50)         (50)                                                
      Acinus, Adenoma                                  1 (2%)       3 (6%)       1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (48)                                                
      Sarcoma                                                       1 (2%)                                                          
      Schwannoma Malignant                                                       1 (2%)                                             
   Stomach                                            (49)         (50)         (50)                                                
      Forestomach, Fibrosarcoma                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (48)         (50)         (50)                                                
      Bilateral, Medulla, Pheochromocytoma Benign      3 (6%)       1 (2%)       2 (4%)                                             
      Medulla, Pheochromocytoma Benign                13 (27%)     10 (20%)      6 (12%)                                            
   Islets, Pancreatic                                 (48)         (50)         (50)                                                
      Adenoma                                          4 (8%)       3 (6%)       1 (2%)                                             
   Pituitary Gland                                    (50)         (48)         (45)                                                
      Pars Distalis, Adenoma                          11 (22%)     10 (21%)      1 (2%)                                             
      Pars Distalis, Adenoma, Multiple                 1 (2%)       2 (4%)       1 (2%)                                             
   Thyroid Gland                                      (49)         (49)         (47)                                                
                                                             Page   6                                                               
NTP Experiment-Test: 05053-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:04:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Adenoma                                  2 (4%)       1 (2%)       3 (6%)                                             
      C-Cell, Carcinoma                                                          1 (2%)                                             
      Follicular Cell, Carcinoma                                    3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Adenoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (45)         (49)         (41)                                                
   Preputial Gland                                    (41)         (38)         (34)                                                
      Adenoma                                          4 (10%)      3 (8%)                                                          
      Carcinoma                                        5 (12%)      2 (5%)       1 (3%)                                             
      Bilateral, Carcinoma                             1 (2%)                                                                       
   Prostate                                           (49)         (46)         (50)                                                
   Seminal Vesicle                                    (50)         (48)         (50)                                                
   Testes                                             (50)         (50)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           33 (66%)     41 (82%)     29 (58%)                                            
      Interstitial Cell, Adenoma                      13 (26%)      4 (8%)       8 (16%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (48)                                                
   Lymph Node                                         (50)         (48)         (49)                                                
      Carcinoma, Metastatic, Lung                                                1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic                                   1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)                                                
   Thymus                                             (47)         (46)         (41)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (20)         (15)         (19)                                                
      Fibroadenoma                                     4 (20%)                                                                      
      Fibroadenoma, Multiple                           1 (5%)       1 (7%)                                                          
   Skin                                               (49)         (49)         (50)                                                
      Basosquamous Tumor Benign                        2 (4%)                                                                       
      Keratoacanthoma                                  1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)       1 (2%)                                                          
      Sebaceous Gland, Adenoma                                      1 (2%)                                                          
                                                             Page   7                                                               
NTP Experiment-Test: 05053-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:04:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Fibroma                     4 (8%)       4 (8%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Osteosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)                       (1)                                                 
      Hepatocellular Carcinoma, Metastatic             1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Astrocytoma Malignant                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                                  1 (2%)       1 (2%)                                             
      Carcinoma                                                                  1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic             1 (2%)                                                                       
      Squamous Cell Carcinoma, Multiple                1 (2%)                                                                       
   Nose                                               (45)         (46)         (38)                                                
      Carcinoma                                                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Skin        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (3)          (2)                                                 
      Adenoma                                                       1 (33%)                                                         
   Zymbal's Gland                                     (1)          (2)          (1)                                                 
      Carcinoma                                        1 (100%)     2 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Renal Tubule, Adenocarcinoma                                               1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (48)         (49)         (50)                                                
                                                             Page   8                                                               
NTP Experiment-Test: 05053-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:04:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            14 (28%)      9 (18%)      5 (10%)                                            
      Lymphoma Malignant Lymphocytic                                             1 (2%)                                             
      Mesothelioma Benign                              2 (4%)       1 (2%)                                                          
      Mesothelioma Malignant                                                     4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05053-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:04:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          49          42                                                   
     Total Primary Neoplasms                          130         112          75                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          47          38                                                   
     Total Benign Neoplasms                           104          90          55                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          21          14                                                   
     Total Malignant Neoplasms                         26          22          20                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       2                                                   
     Total Metastatic Neoplasm                          4                       3                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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