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TDMS Study 05057-02 Pathology Tables

NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97
Route: DOSED FEED                                                                                                 Time: 10:46:48




       Facility:  TSI Mason Research

       Chemical CAS #:  5982043-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 2| 1| 7| 7| 7| 4| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 3| 3| 3| 6| 7| 3| 3| 3| 5| 7| 3| 3| 3| 7| 7|             
                                           | 1| 1| 1| 1| 8| 1| 1| 1| 2| 5| 2| 1| 1| 3| 8| 1| 1| 2| 6| 8| 2| 2| 2| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  M  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  +  +  M  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  M  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  A     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  M  +  +  +  A     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  +  M  A     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +  A     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Hemangioma                           |                                                                          |             
      Hepatocellular Carcinoma             |                         X                                                |             
      Hepatocellular Adenoma               |       X                                            X           X         |             
      Hepatocellular Adenoma, Multiple     |                                              X                           |             
      Hepatocholangiocarcinoma             |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    M                                   M                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  M     +  +  +        +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  M  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Squamous Cell Papilloma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  A     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 2| 1| 7| 7| 7| 4| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 3| 3| 3| 6| 7| 3| 3| 3| 5| 7| 3| 3| 3| 7| 7|             
                                           | 1| 1| 1| 1| 8| 1| 1| 1| 2| 5| 2| 1| 1| 3| 8| 1| 1| 2| 6| 8| 2| 2| 2| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  M     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +     M  +  +  I  M  +  M  +  +     +  +  M        M  +  M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  M  +     +  M  +  +  +  +  M  +  +     +  +  M        +  M  +      |             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  M  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Cystadenoma                          |                                                                          |             
      Granulosa Cell Tumor Benign          |                                                                X         |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                        A                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Polyp Stromal                        |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                 X                        |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                                 X                        |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                 X                        |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 2| 1| 7| 7| 7| 4| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 3| 3| 3| 6| 7| 3| 3| 3| 5| 7| 3| 3| 3| 7| 7|             
                                           | 1| 1| 1| 1| 8| 1| 1| 1| 2| 5| 2| 1| 1| 3| 8| 1| 1| 2| 6| 8| 2| 2| 2| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Undifferentiated Cell Type       |                                                 X                        |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  M  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +     +  +  +  +  +  +  +  +  M     +  +  +        M  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  A     +  +  +        +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  M  +  +  +  +  +  +  M     +  +  +        +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M     M  +  +  +  +  +  +  M  +     +  +  +        +  +  +      |             
      Adenocarcinoma                       |                            X                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 2| 1| 7| 7| 7| 4| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 3| 3| 3| 6| 7| 3| 3| 3| 5| 7| 3| 3| 3| 7| 7|             
                                           | 1| 1| 1| 1| 8| 1| 1| 1| 2| 5| 2| 1| 1| 3| 8| 1| 1| 2| 6| 8| 2| 2| 2| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Harderian Gland                  |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  M  +  +     +  +  M        +  +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  A     +  +  +        +  +  +      |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 1| 7| 5| 4| 1| 1| 7| 7| 7| 4| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 5| 7| 7| 3| 3| 3| 6| 7|             
                                           | 2| 2| 2| 2| 6| 2| 2| 2| 3| 6| 2| 2| 2| 2| 7| 2| 2| 6| 8| 8| 2| 2| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  M     +  +  +  +     +  +           M  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  M  +  +   |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  M  +  +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     M  +  +  +     +  +  +  +     +  A           M  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  +  +  +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  M  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Hemangioma                           |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Hepatocholangiocarcinoma             |                               X                                          |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                               M   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Squamous Cell Papilloma              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 1| 7| 5| 4| 1| 1| 7| 7| 7| 4| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 5| 7| 7| 3| 3| 3| 6| 7|             
                                           | 2| 2| 2| 2| 6| 2| 2| 2| 3| 6| 2| 2| 2| 2| 7| 2| 2| 6| 8| 8| 2| 2| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M     M  +  +  M     +  M  M  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +     +  +  M  +     +  +           +  +  +  +   |             
      Pars Distalis, Adenoma               |                                  X     X                             X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  M     +  +  +  +     +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Cystadenoma                          | X                    X                                                   |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Polyp Stromal                        |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | I  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 1| 7| 5| 4| 1| 1| 7| 7| 7| 4| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 5| 7| 7| 3| 3| 3| 6| 7|             
                                           | 2| 2| 2| 2| 6| 2| 2| 2| 3| 6| 2| 2| 2| 2| 7| 2| 2| 6| 8| 8| 2| 2| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | I  +  +  +     +  +  +  +     M  +  +  M     +  +           +  +  +  +   |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                             X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +     +  +  +  +     +  +  +  +     +  +           +  M  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                        X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
      Lymphoma Malignant Mixed             |    X                                                        X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  M  +  M     +  +  +  +     +  M           +  +  +  M   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  M     +  +  M  M     +  +  M  +     M  +           M  M  M  +   |             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma                              |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 1| 7| 5| 4| 1| 1| 7| 7| 7| 4| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 5| 7| 7| 3| 3| 3| 6| 7|             
                                           | 2| 2| 2| 2| 6| 2| 2| 2| 3| 6| 2| 2| 2| 2| 7| 2| 2| 6| 8| 8| 2| 2| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Harderian Gland                  |                                                 X                        |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                     X                                    |             
      Alveolar/Bronchiolar Carcinoma       |                                  X                                       |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  M  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  M     +  +  +  +     +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                        |             
      Adenocarcinoma                       |                                                 X                        |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                        X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 1| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 6| 4| 4| 4|              |            |
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|              |            |
                                           | 2| 2| 2| 6| 8| 5| 2| 2| 6| 6| 5| 5| 2| 2| 6| 2| 4| 6| 6| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  46        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  47        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Hemangioma                           |                                                 X                        |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                      X                                                   |          4 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Hepatocholangiocarcinoma             |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  48        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
      Squamous Cell Papilloma              | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   2        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 1| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 6| 4| 4| 4|              |            |
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|              |            |
                                           | 2| 2| 2| 6| 8| 5| 2| 2| 6| 6| 5| 5| 2| 2| 6| 2| 4| 6| 6| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  37        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +  +        +  +  +  +     +  +                        |  42        |
      Pars Distalis, Adenoma               |                                     X  X                                 |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  48        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Cystadenoma                          |                                                                          |          2 |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Polyp Stromal                        |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 1| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 6| 4| 4| 4|              |            |
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|              |            |
                                           | 2| 2| 2| 6| 8| 5| 2| 2| 6| 6| 5| 5| 2| 2| 6| 2| 4| 6| 6| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M        +  +  +  +     +  +  +  +     +  +                        |  45        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  45        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                                     X           X                        |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M        +  +  +  +     +  +  +  +     +  +                        |  43        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                                     X                                    |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +        M  +  +  +     M  M  +  +     +  M                        |  31        |
      Adenocarcinoma                       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 1| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 6| 4| 4| 4|              |            |
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|              |            |
                                           | 2| 2| 2| 6| 8| 5| 2| 2| 6| 6| 5| 5| 2| 2| 6| 2| 4| 6| 6| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                                |   2        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                              X                           |          1 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                     X                                    |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  47        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   2        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 1| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 6| 4| 4| 4|              |            |
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|              |            |
                                           | 2| 2| 2| 6| 8| 5| 2| 2| 6| 6| 5| 5| 2| 2| 6| 2| 4| 6| 6| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |       X                             X           X                        |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 6| 1| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 0| 5| 3| 3| 1| 7| 5| 3| 3| 6| 7| 7| 3| 3| 3| 7| 7|             
                                           | 0| 0| 0| 0| 2| 0| 0| 0| 4| 6| 0| 0| 8| 6| 6| 0| 0| 4| 8| 7| 1| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +                                                            |             
                                            __________________________________________________________________________|             
   Gallbladder                             |             +                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +  +                                +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +        +                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +  +                                +                           |             
      Lymphoma Malignant Mixed             |                                              X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +        +                                                            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |             +        +  +           +              +        +  +  +      |             
      Hepatocellular Adenoma               |                                                                X  X      |             
      Hepatocellular Adenoma, Multiple     |                      X                                                   |             
      Lymphoma Malignant Histiocytic       |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +                                                            |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +                       +  +        +                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +                       +  +        +                        |             
      Squamous Cell Papilloma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +                          +        +                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +                                      +                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             M                                                            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             M                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 6| 1| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 0| 5| 3| 3| 1| 7| 5| 3| 3| 6| 7| 7| 3| 3| 3| 7| 7|             
                                           | 0| 0| 0| 0| 2| 0| 0| 0| 4| 6| 0| 0| 8| 6| 6| 0| 0| 4| 8| 7| 1| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +     +  M  +        +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  M     +  +  +        +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +                    +     +        +  +        +     +      |             
      Lymphoma Malignant Histiocytic       |                                                    X                     |             
      Polyp Stromal                        |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +  +  M     +        +  +        +     +                     |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                         X                                                |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                  X                                       |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                     X                                    |             
      Pancreatic, Lymphoma Malignant Mixed |                X                                                         |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                X                                                         |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +                    M                 +                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +     M           +        +           +                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                              X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X        X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +  +  +     +        +  +  +     +                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 6| 1| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 0| 5| 3| 3| 1| 7| 5| 3| 3| 6| 7| 7| 3| 3| 3| 7| 7|             
                                           | 0| 0| 0| 0| 2| 0| 0| 0| 4| 6| 0| 0| 8| 6| 6| 0| 0| 4| 8| 7| 1| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Skeletal Muscle                  |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                                              X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X        X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  M           +                                                |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +                                                            |             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +     +        +  +        +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +                                                            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
      Hemangiosarcoma                      |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +                       +              +                     |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +                       +           +                        |             
      Alveolar/Bronchiolar Adenoma         |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
      Adenoma                              |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +           +                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +                                      +                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 6| 1| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 0| 5| 3| 3| 1| 7| 5| 3| 3| 6| 7| 7| 3| 3| 3| 7| 7|             
                                           | 0| 0| 0| 0| 2| 0| 0| 0| 4| 6| 0| 0| 8| 6| 6| 0| 0| 4| 8| 7| 1| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                X                             X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X        X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 4| 7| 6| 7| 1| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 1| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 4| 5| 5| 5| 3| 8| 3| 7| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5|             
                                           | 0| 7| 6| 6| 6| 0| 8| 0| 7| 7| 1| 1| 6| 8| 8| 1| 1| 1| 1| 8| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                   +  +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                   +  +                                                   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                   +  +                                                   |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                   X  X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                   +  +                                                   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                   X                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +              +  +                          +                       +   |             
      Hepatocellular Adenoma               | X              X                                                         |             
      Hepatocellular Adenoma, Multiple     |                                              X                           |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                   X                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 4| 7| 6| 7| 1| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 1| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 4| 5| 5| 5| 3| 8| 3| 7| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5|             
                                           | 0| 7| 6| 6| 6| 0| 8| 0| 7| 7| 1| 1| 6| 8| 8| 1| 1| 1| 1| 8| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +           +  +  +        +  +           +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | M  +           +  +  +        +  +           +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +              +     +                          +     +                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +              +  +                                                   |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |    X                                                                     |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |    X                                                                     |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                   X                                                      |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |    X                                                                     |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|    X                                                                     |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +                 M                                                   |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +              +  +                                                   |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                   X  X                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +              +  +                             +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 4| 7| 6| 7| 1| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 1| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 4| 5| 5| 5| 3| 8| 3| 7| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5|             
                                           | 0| 7| 6| 6| 6| 0| 8| 0| 7| 7| 1| 1| 6| 8| 8| 1| 1| 1| 1| 8| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Skeletal Muscle                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                   X  X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +                                         +                           |             
      Lymphoma Malignant Lymphocytic       |    X                                         X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                   +                                                      |             
      Adenocarcinoma                       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +           M  +           +  +           +  +  +        +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +           +  +  +        +  +           +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                                         X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 4| 7| 6| 7| 1| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 1| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 4| 5| 5| 5| 3| 8| 3| 7| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5|             
                                           | 0| 7| 6| 6| 6| 0| 8| 0| 7| 7| 1| 1| 6| 8| 8| 1| 1| 1| 1| 8| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                   X  X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 6| 1| 7| 7| 7| 4| 1| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 5| 9| 3| 3| 2| 1| 1|              |            |
                                           | 1| 6| 1| 1| 6| 1| 1| 1| 2| 8| 1| 1| 1| 6| 2| 1| 1| 2| 1| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                           M              +               |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +                 +        +           +  +               |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +                 +        +           +  +               |   9        |
      Lymphoma Malignant Mixed             |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +                 +        +           +  +               |  11        |
      Lymphoma Malignant Mixed             |                                                       X                  |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                  X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +                 +        M           +  +               |   8        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +  +                       +           +  +               |  18        |
      Hepatocellular Adenoma               |                X  X                                                      |          6 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                       X                  |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   1        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                           M              +               |   2        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                   +                       +              +               |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                   +                       +              +               |   7        |
      Squamous Cell Papilloma              |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                   +                       +              +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                           +              +               |   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                           +              +               |   3        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 6| 1| 7| 7| 7| 4| 1| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 5| 9| 3| 3| 2| 1| 1|              |            |
                                           | 1| 6| 1| 1| 6| 1| 1| 1| 2| 8| 1| 1| 1| 6| 2| 1| 1| 2| 1| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                           +              +               |   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                           M              M               |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +     +  +  +  +     +  +  +     +  +  +  +  +  +               |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  +     +  +  +  +     +  +  +     +  M  +  +  +  +               |  47        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +                 +     +           +  +  +     +  +               |  24        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                           +           +  +               |  15        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                       X                  |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                                                       X                  |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                          X               |          3 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                       X                  |          2 |
      Renal, Lymphoma Malignant            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 6| 1| 7| 7| 7| 4| 1| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 5| 9| 3| 3| 2| 1| 1|              |            |
                                           | 1| 6| 1| 1| 6| 1| 1| 1| 2| 8| 1| 1| 1| 6| 2| 1| 1| 2| 1| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                           +           +  M               |   5        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                           M           +  +               |  10        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                       X                  |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                   +                       M           +  +               |  17        |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Skeletal Muscle                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                       X                  |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          5 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                     M     M              +               |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                           M              M               |   2        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +     +  +  +     M  +     +  +  +               |  40        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                           +              +               |   4        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                           +              +               |   5        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                         +                 +  +     +     +               |   8        |
      Alveolar/Bronchiolar Adenoma         |                         X                                                |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 6| 1| 7| 7| 7| 4| 1| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 5| 9| 3| 3| 2| 1| 1|              |            |
                                           | 1| 6| 1| 1| 6| 1| 1| 1| 2| 8| 1| 1| 1| 6| 2| 1| 1| 2| 1| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                           +              +               |   3        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                           +              +               |   4        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                           +              +               |   4        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +  +     +  +  +  +     +  +  +     +  +  +  +  +  +               |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
      Lymphoma Malignant Mixed             |                X                                      X                  |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                  X                       X               |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|             
                                           | 0| 0| 0| 6| 8| 0| 0| 6| 7| 7| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  M   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +  M           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hepatocellular Adenoma               |                X                                   X                     |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                     X                                X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                      +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +           +  +  +  +     +  M  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|             
                                           | 0| 0| 0| 6| 8| 0| 0| 6| 7| 7| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M        +  +           M  +  +  M     +  M  +  +  M  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +           M  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Cystadenoma                          |                                                             X  X         |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
      Teratoma                             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
      Sarcoma Stromal                      |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                     X                                X   |             
      Pancreatic, Lymphoma Malignant Mixed |                                     X                                X   |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +        M  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                     X                                X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                     X                                X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +        +  +           +  +  +  M     M  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|             
                                           | 0| 0| 0| 6| 8| 0| 0| 6| 7| 7| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M        +  +           +  +  M  +     +  M  +  +  +  +  +  +  M   |             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                X   |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  M  M  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|             
                                           | 0| 0| 0| 6| 8| 0| 0| 6| 7| 7| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4| 1| 7| 7| 4| 4| 1| 7| 7| 6| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 5| 3| 2| 5| 5| 7| 3| 3| 5| 5| 7| 3| 3| 1| 7| 7|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 6| 0| 9| 6| 6| 8| 0| 0| 6| 6| 8| 0| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  M  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +  +  +  +     +  +           +  +           +  +  M      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Hepatocellular Adenoma               |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                  X                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Squamous Cell Papilloma              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  +        M  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4| 1| 7| 7| 4| 4| 1| 7| 7| 6| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 5| 3| 2| 5| 5| 7| 3| 3| 5| 5| 7| 3| 3| 1| 7| 7|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 6| 0| 9| 6| 6| 8| 0| 0| 6| 6| 8| 0| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +  +  I  +     I  M           +  I           +  M  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  I  +        +  +  +  +     +  +           M  M           +  +  +      |             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Cystadenoma                          |                               X                                          |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Teratoma                             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |    X                                                                     |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |    X                                                                     |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                  X                                       |             
      Renal, Lymphoma Malignant Mixed      |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +        M  M  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  I     +  +           M  +           M  +  +      |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                  X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        +  +  +  +     M  +           +  +           +  +  M      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4| 1| 7| 7| 4| 4| 1| 7| 7| 6| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 5| 3| 2| 5| 5| 7| 3| 3| 5| 5| 7| 3| 3| 1| 7| 7|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 6| 0| 9| 6| 6| 8| 0| 0| 6| 6| 8| 0| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +        +  +  M  M     +  +           +  +           +  +  +      |             
      Adenocarcinoma                       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |       X                                                                  |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +  +  +  +     M  +           +  +           M  +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4| 1| 7| 7| 4| 4| 1| 7| 7| 6| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 5| 3| 2| 5| 5| 7| 3| 3| 5| 5| 7| 3| 3| 1| 7| 7|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 6| 0| 9| 6| 6| 8| 0| 0| 6| 6| 8| 0| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X        X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 7| 5| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 4| 5| 3| 3| 3| 7| 7|              |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 0| 0| 0| 7| 6| 0| 0| 0| 8| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +     +  +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  48        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Hepatocellular Adenoma               |                      X                       X                           |          4 |
      Lymphoma Malignant Histiocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                                        X                                 |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +                  |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Lymphoma Malignant Mixed             |                                        X                                 |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 7| 5| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 4| 5| 3| 3| 3| 7| 7|              |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 0| 0| 0| 7| 6| 0| 0| 0| 8| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  I  +  M  +  +  +  M  M  +  M  +     +  M  +  M                  |  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  45        |
      Pars Distalis, Adenoma               |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Cystadenoma                          |                                                                          |          3 |
      Granulosa Cell Tumor Benign          |    X                                                                     |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Teratoma                             |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Lymphoma Malignant Histiocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma Stromal                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Lymphoma Malignant Mixed             |                                        X                                 |          1 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  49        |
      Axillary, Lymphoma Malignant Mixed   |                                        X                                 |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                        X              X                  |          3 |
      Mediastinal, Lymphoma Malignant Mixed|                                        X                                 |          3 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          3 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                        X              X                  |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  45        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 7| 5| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 4| 5| 3| 3| 3| 7| 7|              |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 0| 0| 0| 7| 6| 0| 0| 0| 8| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                        X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | I  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +                  |  44        |
      Lymphoma Malignant Mixed             |                                        X              X                  |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Lymphoma Malignant Mixed             |                                        X                                 |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  M  +  +  M  +  +  +  +  +     M  +  +  +                  |  41        |
      Lymphoma Malignant Mixed             |                                        X                                 |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  M  +  M  +  +  M     +  +  +  +                  |  37        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                             |   2        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                      X                                                   |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                        X                                 |          3 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                            X                                             |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 7| 5| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 4| 5| 3| 3| 3| 7| 7|              |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 0| 0| 0| 7| 6| 0| 0| 0| 8| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                                                                     |   2        |
      Adenoma                              |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Lymphoma Malignant Histiocytic       |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                                        X              X                  |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 3| 1| 7| 4| 4| 4| 3| 5| 4| 7| 7| 1| 5| 4| 4| 3| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 9| 8| 3| 5| 2| 0| 2| 1| 5| 3| 3| 8| 0| 5| 5| 7| 8|             
                                           | 4| 4| 4| 4| 3| 4| 4| 4| 8| 9| 4| 6| 0| 9| 2| 9| 6| 4| 4| 9| 8| 5| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     M     +  +  +  +     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  M  M     +     M  A  +  +     +  +     M        A   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +     +     +  M  +  +     +  +     +        A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +     +     M  +  +  +     M  +     +        A   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  M  +  +  +  A     +     +  +  +  +     +  +     +        A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  A     +     +  +  +  A     +  +     +        A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  A     +     A  M  +  +     +  +     +        A   |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  A     +     +  +  +  A     +  +     +        A   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                              X                           |             
      Hemangiosarcoma, Multiple            |                                                                          |             
      Hepatocellular Carcinoma             |          X           X                                                   |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |                   X                                                      |             
      Lipoma                               |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        M                             A   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  M     +     +  +  +  +     +  +     +        +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  A  +  +  +  +     +     +  +  +  +     +  +     +        A   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +     +     +  +  +  +     +  +     +        M   |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +     +     +  +  +  +     +  +     +        A   |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 3| 1| 7| 4| 4| 4| 3| 5| 4| 7| 7| 1| 5| 4| 4| 3| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 9| 8| 3| 5| 2| 0| 2| 1| 5| 3| 3| 8| 0| 5| 5| 7| 8|             
                                           | 4| 4| 4| 4| 3| 4| 4| 4| 8| 9| 4| 6| 0| 9| 2| 9| 6| 4| 4| 9| 8| 5| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type, Minimal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Adenoma                              |                                                                          |             
      Adenoma, Multiple                    |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  M     +     +  +  +  +     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  I  M  +  +     M     +  M  M  M     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  I  +  +  M  +     +     +  M  M  M     M  +     +        +   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     M     +  +  M  +     +  +     +        +   |             
      Follicular Cell, Adenoma             |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |             M           +           +     +                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +              +        +              +                  |             
      Fibrosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Sertoli Cell Tumor Benign            |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        M   |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 3| 1| 7| 4| 4| 4| 3| 5| 4| 7| 7| 1| 5| 4| 4| 3| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 9| 8| 3| 5| 2| 0| 2| 1| 5| 3| 3| 8| 0| 5| 5| 7| 8|             
                                           | 4| 4| 4| 4| 3| 4| 4| 4| 8| 9| 4| 6| 0| 9| 2| 9| 6| 4| 4| 9| 8| 5| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +     +     M  +  +  +     +  +     +        M   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  A  I  +  +  +     M     +  A  M  +     +  +     +        M   |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  A  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Hemangiosarcoma                      |                                              X                           |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  A  +  M  M  M     M     +  A  M  M     +  +     +        +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M     M     M  M  M  M     +  M     M        M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +     M  +  +  +     +  +     +        +   |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                             X            |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Alveolar/Bronchiolar Adenoma         | X                                                                        |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     M     +  +  +  +     +  +     +        +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 3| 1| 7| 4| 4| 4| 3| 5| 4| 7| 7| 1| 5| 4| 4| 3| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 9| 8| 3| 5| 2| 0| 2| 1| 5| 3| 3| 8| 0| 5| 5| 7| 8|             
                                           | 4| 4| 4| 4| 3| 4| 4| 4| 8| 9| 4| 6| 0| 9| 2| 9| 6| 4| 4| 9| 8| 5| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +     +     +  A  +  +     +  +     +        A   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 4| 1| 1| 7| 4| 7| 6| 1| 7| 7| 7| 7| 7| 4| 7| 7| 1| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 4| 5| 2| 5| 8| 8| 2| 5| 3| 9| 8| 3| 3| 3| 3| 2| 5| 3| 3| 8| 5|             
                                           | 4| 4| 4| 3| 9| 6| 1| 6| 9| 9| 3| 6| 4| 2| 9| 4| 4| 4| 4| 3| 5| 4| 4| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +     +           +     +  M     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +     +           +     +  A     M  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            |                   X                                                      |             
      Hepatocellular Carcinoma             | X                                                                        |             
      Hepatocellular Carcinoma, Multiple   |          X                                                               |             
      Hepatocellular Adenoma               |                                     X                             X      |             
      Lipoma                               |                                                                   X      |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +           +     +  M     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Squamous Cell Papilloma              | X                                                     X           X      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 4| 1| 1| 7| 4| 7| 6| 1| 7| 7| 7| 7| 7| 4| 7| 7| 1| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 4| 5| 2| 5| 8| 8| 2| 5| 3| 9| 8| 3| 3| 3| 3| 2| 5| 3| 3| 8| 5|             
                                           | 4| 4| 4| 3| 9| 6| 1| 6| 9| 9| 3| 6| 4| 2| 9| 4| 4| 4| 4| 3| 5| 4| 4| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                             +  +                       +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type, Minimal               |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Adenoma                              |                                                    X                     |             
      Adenoma, Multiple                    |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M     +           +     +  M     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +     M           +     +  M     +  +  +  +  M     M  +     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +     M           +     +  +     +  +  +  +  +     +  +     M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                                   +  +                 +      |             
      Fibrosarcoma                         |          X                                                               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  M  M     +           +     +  +     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Sertoli Cell Tumor Benign            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |             X                                                            |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 4| 1| 1| 7| 4| 7| 6| 1| 7| 7| 7| 7| 7| 4| 7| 7| 1| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 4| 5| 2| 5| 8| 8| 2| 5| 3| 9| 8| 3| 3| 3| 3| 2| 5| 3| 3| 8| 5|             
                                           | 4| 4| 4| 3| 9| 6| 1| 6| 9| 9| 3| 6| 4| 2| 9| 4| 4| 4| 4| 3| 5| 4| 4| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +           +     +  M     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  M  +  +     +           M     +  I     +  +  +  +  M     +  M     +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M     M           M     M  M     M  M  M  M  M     M  M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Subcutaneous Tissue, Fibrosarcoma    |                               X                          X               |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Alveolar/Bronchiolar Adenoma         |          X        X                          X  X  X                     |             
      Alveolar/Bronchiolar Carcinoma       |                                                    X  X                  |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                           +         |             
      Adenoma                              |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 4| 1| 1| 7| 4| 7| 6| 1| 7| 7| 7| 7| 7| 4| 7| 7| 1| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 4| 5| 2| 5| 8| 8| 2| 5| 3| 9| 8| 3| 3| 3| 3| 2| 5| 3| 3| 8| 5|             
                                           | 4| 4| 4| 3| 9| 6| 1| 6| 9| 9| 3| 6| 4| 2| 9| 4| 4| 4| 4| 3| 5| 4| 4| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 6| 4| 2| 1| 1| 4| 7| 6| 2| 0| 7| 7| 7| 1| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 9| 5| 2| 8| 4| 5| 3| 1| 4| 6| 3| 3| 3| 8| 9|              |            |
                                           | 4| 4| 4| 4| 4| 4| 6| 4| 9| 6| 6| 4| 6| 8| 2| 4| 4| 4| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  M     +     +     +  +  +  +  +  +  +                     |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  +     +     M     +  +  +  +  +  +  +                     |  39        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +     +     +     +  A  +  +  +  +  +                     |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  M  +     +     +     +  A  +  +  +  +  +                     |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +     +     +  A  +  +  +  +  +                     |  47        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +     +     +     +  A  M  +  +  +  +                     |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +     +     +     +  A  A  +  +  +  +                     |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +     +     +     +  A  A  +  +  +  +                     |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +     +     +     +  A  A  +  +  +  +                     |  41        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +     +     +     +  A  A  +  +  +  +                     |  42        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  49        |
      Hemangioma                           |          X                                                               |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Hepatocellular Carcinoma             |                X                                                         |          4 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |          X                       X           X  X  X                     |          8 |
      Lipoma                               |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  A  +     +     +     +  +  M  +  +  +  +                     |  45        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 6| 4| 2| 1| 1| 4| 7| 6| 2| 0| 7| 7| 7| 1| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 9| 5| 2| 8| 4| 5| 3| 1| 4| 6| 3| 3| 3| 8| 9|              |            |
                                           | 4| 4| 4| 4| 4| 4| 6| 4| 9| 6| 6| 4| 6| 8| 2| 4| 4| 4| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +     +     +     +  +  A  +  +  +  +                     |  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +     +     +  +  A  +  +  +  +                     |  46        |
      Squamous Cell Papilloma              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +     +     +  +  A  +  +  +  +                     |  46        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +                                         +  +  +                     |   9        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type, Minimal               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Adenoma                              |                                                                          |          1 |
      Adenoma, Multiple                    |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +     +     +     +  +  M  +  +  +  +                     |  45        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  M  +  I     +     M     M  +  M  M  +  +  M                     |  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +     +     +     +  +  +  +  +  M  M                     |  38        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +     +     +     +  +  +  +  +  +  +                     |  47        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                      +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                      +                                                   |   9        |
      Fibrosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | M  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  47        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 6| 4| 2| 1| 1| 4| 7| 6| 2| 0| 7| 7| 7| 1| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 9| 5| 2| 8| 4| 5| 3| 1| 4| 6| 3| 3| 3| 8| 9|              |            |
                                           | 4| 4| 4| 4| 4| 4| 6| 4| 9| 6| 6| 4| 6| 8| 2| 4| 4| 4| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Sertoli Cell Tumor Benign            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +     +     +  +  +  M  +  +  +                     |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  M     +     +     +  M  +  +  +  +  +                     |  46        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M     +     +     +  M  +  M  +  +  +                     |  42        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  M     M     +     +  M  M  +  +  +  +                     |  38        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  A  M     M     +     +  M  M  +  +  +  +                     |  28        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M     M     M     M  M  M  M  M  M  M                     |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  49        |
      Subcutaneous Tissue, Fibrosarcoma    |    X                                         X                           |          5 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
           Multiple                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 6| 4| 2| 1| 1| 4| 7| 6| 2| 0| 7| 7| 7| 1| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 9| 5| 2| 8| 4| 5| 3| 1| 4| 6| 3| 3| 3| 8| 9|              |            |
                                           | 4| 4| 4| 4| 4| 4| 6| 4| 9| 6| 6| 4| 6| 8| 2| 4| 4| 4| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |          7 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  M  +  +     +     +     +  +  +  +  +  +  +                     |  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +     +     +     +  +  M  +  +  +  +                     |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                     +                                    |   1        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +     +     +     +  +  A  +  +  +  +                     |  44        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  50                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 1| 0| 6| 7| 7| 4| 0| 7| 4| 3| 2| 1| 7| 7| 5| 5| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 3| 5| 5| 9| 2| 3| 3| 5| 7| 3| 5| 7| 7| 0| 3| 3| 1| 9| 8| 3| 3| 3| 3| 8|             
                                           | 1| 4| 5| 2| 4| 6| 4| 4| 5| 3| 4| 6| 7| 3| 0| 4| 5| 2| 2| 9| 5| 5| 5| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +  +           +        +     +        +  M                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             |          A  M  +           M        +     +        M  +                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +  +  +           A        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          M  +  +           A        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +  +  +           A        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +  +  +           A        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          A  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          M  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          A  +  +           A        +     +        +  +                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          A  +  +           A        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Liver                                   |          +  +  +  +        +        +     +        +  +           +      |             
      Hepatocellular Carcinoma             |                   X                                   X           X      |             
      Hepatocellular Carcinoma, Multiple   |                                                    X                     |             
      Hepatocellular Adenoma               |                X  X                                X              X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +  +  +           +        +     +        +  +              +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +  +  +           +        +     +        +  +              +   |             
      Squamous Cell Papilloma              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +  +           +        +     +        +  +                  |             
      Sarcoma, Metastatic, Skeletal Muscle |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          +  M  +           M        M     +        M  M                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +  +  +           +        M     M        +  +                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +     +  +     +     +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +  +     +  +     +     +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Penis                                   |          +                                      +           +     +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 1| 0| 6| 7| 7| 4| 0| 7| 4| 3| 2| 1| 7| 7| 5| 5| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 3| 5| 5| 9| 2| 3| 3| 5| 7| 3| 5| 7| 7| 0| 3| 3| 1| 9| 8| 3| 3| 3| 3| 8|             
                                           | 1| 4| 5| 2| 4| 6| 4| 4| 5| 3| 4| 6| 7| 3| 0| 4| 5| 2| 2| 9| 5| 5| 5| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +  +              +                    +                 +   |             
                                            __________________________________________________________________________|             
   Prostate                                |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +  +  +           +        +     +        +  +        +         |             
                                            __________________________________________________________________________|             
   Testes                                  |          +  +  +           +        +     +        +  +                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +     +     +  +     M     +  +     +  +        +         |             
      Mediastinal, Pancreatic, Sarcoma,    |                                                                          |             
           Metastatic, Skeletal Muscle     |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          M  +  M           M        M     M        +  +                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +  M  +     +     +  +     M     +  +     +  +        +         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +  +  +           +        +     +  +     +  +                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +  M  +           +        M     +        +  M                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          M  M  M           M        M     M        M  M                  |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +  +  +  +     +        +     +  +     +  +        +         |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +     +     +  +     +     +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Sarcoma                              |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +  +  +           +        +     +        +  +     +            |             
      Meningioma Benign                    |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +  +  +           +  +     +     +     +  +  +     +  +     +   |             
      Alveolar/Bronchiolar Adenoma         |                               X                             X        X   |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Sarcoma, Metastatic, Skeletal Muscle |                X                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +  +  +           +        +     +        +  +                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 1| 0| 6| 7| 7| 4| 0| 7| 4| 3| 2| 1| 7| 7| 5| 5| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 3| 5| 5| 9| 2| 3| 3| 5| 7| 3| 5| 7| 7| 0| 3| 3| 1| 9| 8| 3| 3| 3| 3| 8|             
                                           | 1| 4| 5| 2| 4| 6| 4| 4| 5| 3| 4| 6| 7| 3| 0| 4| 5| 2| 2| 9| 5| 5| 5| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +  +  +           +        +     +        +  +                  |             
      Sarcoma, Metastatic, Skeletal Muscle |                X                                                         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +  +  +  +  +     +        A     +        +  +                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +  +  +     +  +     +     +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 1| 1| 1| 7| 7| 7| 4| 3| 7| 7| 7| 4| 1| 7| 4| 5| 7| 1| 7| 7| 3| 2| 1|             
                             DAY ON TEST   | 3| 5| 8| 8| 9| 3| 3| 3| 5| 9| 3| 3| 3| 5| 8| 3| 5| 6| 3| 8| 3| 3| 2| 9| 9|             
                                           | 5| 6| 9| 9| 0| 5| 5| 5| 6| 9| 5| 6| 6| 6| 9| 6| 5| 7| 6| 9| 6| 6| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                            +                       +              +  I   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                            +                       +              +  +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   |                            +                       +        +     +  +   |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Carcinoma, Multiple   |                                                    X                     |             
      Hepatocellular Adenoma               |                                                    X        X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            M                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |                            +                       +           +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                            +                       +           +  +  +   |             
      Squamous Cell Papilloma              |                                                                X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                            +                       +              +  +   |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                            +                       +        +     +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                            +                       +        +     +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                            +                       M              +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                            +                       M              M  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                            +                       M              +  +   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +              +  +  +     +  +  +  +        +     +  +     +  +  M  +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +              +  +  +     +  +  +  +        +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 1| 1| 1| 7| 7| 7| 4| 3| 7| 7| 7| 4| 1| 7| 4| 5| 7| 1| 7| 7| 3| 2| 1|             
                             DAY ON TEST   | 3| 5| 8| 8| 9| 3| 3| 3| 5| 9| 3| 3| 3| 5| 8| 3| 5| 6| 3| 8| 3| 3| 2| 9| 9|             
                                           | 5| 6| 9| 9| 0| 5| 5| 5| 6| 9| 5| 6| 6| 6| 9| 6| 5| 7| 6| 9| 6| 6| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                 +  +                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                            +                       +  +           +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  |                            +                       +              +  +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +        +  +     +        +     +              +  +   |             
      Mediastinal, Pancreatic, Sarcoma,    |                                                                          |             
           Metastatic, Skeletal Muscle     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                            M                       +              +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +        +  +     +        +     +              +  M   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                            +                       +           +  +  +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                            M                       M              +  M   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                            M                       M              M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    |                +     +     +  +                    +              +  +   |             
      Subcutaneous Tissue, Fibroma         |                               X                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +              +           +  +  +  +        +     +              +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                            +                       +              +  +   |             
      Meningioma Benign                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                   +  +     +                       +           +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                   X  X                                                   |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                    X                     |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                            M                       +              +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                            +                       +              +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 1| 1| 1| 7| 7| 7| 4| 3| 7| 7| 7| 4| 1| 7| 4| 5| 7| 1| 7| 7| 3| 2| 1|             
                             DAY ON TEST   | 3| 5| 8| 8| 9| 3| 3| 3| 5| 9| 3| 3| 3| 5| 8| 3| 5| 6| 3| 8| 3| 3| 2| 9| 9|             
                                           | 5| 6| 9| 9| 0| 5| 5| 5| 6| 9| 5| 6| 6| 6| 9| 6| 5| 7| 6| 9| 6| 6| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                            +                       +  +        +  +  +   |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                   +      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                            M                       +           +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +              +  +  +     +  +  +  +        +     +  +     +  +  +  +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 4| 4| 1| 7| 7| 4| 6| 7| 7| 6| 2| 4| 1| 6| 7| 7| 3| 1|              |            |
                             DAY ON TEST   | 5| 3| 5| 0| 6| 3| 3| 5| 0| 3| 3| 8| 7| 5| 8| 7| 3| 3| 8| 8|              |            |
                                           | 8| 6| 6| 9| 8| 6| 6| 6| 7| 6| 6| 7| 1| 5| 9| 5| 6| 6| 4| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  A           +           +                 +                  |  15        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          M  A           +           A                 +                  |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +  A           +           M                 +                  |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  A           +           M                 +                  |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  M           +           M                 +                  |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  M           +           M                 +                  |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +  A     +     +           M                 +                  |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +  M     +     +           M                 +                  |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  A     +     +           M                 +                  |  14        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  M     +     +           M                 +                  |  14        |
                                            __________________________________________________________________________|____________|
   Liver                                   |          +  +           +           +        +  +     +                  |  22        |
      Hepatocellular Carcinoma             |                         X                    X                           |          5 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          2 |
      Hepatocellular Adenoma               |                                                 X                        |          7 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  M     +     +           M                 +                  |  16        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +           +           +                 +                  |  17        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +  +  +        +           +                 +                  |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +           +           +                 +                  |  19        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  A  +        +           A                 +                  |  16        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +           +           +                 +                  |  17        |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +  M           +           +                 +                  |  17        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  M           +           +                 +                  |  17        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +  M           +           +                 +                  |  16        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  M     +     +           M                 +                  |  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +  +           M           M                 +                  |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  M           +           +                 +                  |  13        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +  +  +     +  +  +  +  +        +  +  +  +                  |  48        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 4| 4| 1| 7| 7| 4| 6| 7| 7| 6| 2| 4| 1| 6| 7| 7| 3| 1|              |            |
                             DAY ON TEST   | 5| 3| 5| 0| 6| 3| 3| 5| 0| 3| 3| 8| 7| 5| 8| 7| 3| 3| 8| 8|              |            |
                                           | 8| 6| 6| 9| 8| 6| 6| 6| 7| 6| 6| 7| 1| 5| 9| 5| 6| 6| 4| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +  A  +  +     +  +  +  +  +        +  +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Penis                                   |          +                          +           +                        |   8        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +     +        +                                                      |  11        |
                                            __________________________________________________________________________|____________|
   Prostate                                |          M  A           +           +                 +                  |  15        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +  +  +        +           +        +        +                  |  21        |
                                            __________________________________________________________________________|____________|
   Testes                                  |          +  +           +           +                 +                  |  17        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  A           +           +                 +                  |  16        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +  M  +  +     +  +     +  A              +  +                  |  28        |
      Mediastinal, Pancreatic, Sarcoma,    |                                                                          |            |
           Metastatic, Skeletal Muscle     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  M           +           A                 +                  |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +     +  M  +  +     M  +     M  M              +  +                  |  24        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  M     +     +        +  A        +        +                  |  21        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  +           M           A                 +                  |   9        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M  M           M           M                 M                  |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +  +  +        +  +  +  +  +        +  M  +  +                  |  32        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                       X                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +  +  +  +     +     +  +  +           +  +  +                  |  39        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +           +           +                 +                  |  18        |
      Meningioma Benign                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +  +     +     +     +  +  +              +  +                  |  29        |
      Alveolar/Bronchiolar Adenoma         |                   X           X                    X                     |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 4| 4| 1| 7| 7| 4| 6| 7| 7| 6| 2| 4| 1| 6| 7| 7| 3| 1|              |            |
                             DAY ON TEST   | 5| 3| 5| 0| 6| 3| 3| 5| 0| 3| 3| 8| 7| 5| 8| 7| 3| 3| 8| 8|              |            |
                                           | 8| 6| 6| 9| 8| 6| 6| 6| 7| 6| 6| 7| 1| 5| 9| 5| 6| 6| 4| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Carcinoma       |                                  X                                       |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  M           +           I                 +                  |  14        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  A           +           +                 +                  |  16        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  A           +  +     +  +              +  +                  |  22        |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |             M                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  A           +        +  A                 +                  |  17        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +     +  +  +  +     +  +  +  +  +        +  +  +  +                  |  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 1| 7| 6| 3| 2| 1| 7| 7| 7| 7| 2| 7| 7| 4| 4| 1| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 3| 3| 3| 9| 3| 1| 0| 2| 9| 3| 3| 3| 3| 9| 3| 3| 8| 5| 8| 3| 3| 3| 3| 9|             
                                           | 8| 0| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 0| 0| 7| 1| 0| 4| 5| 9| 0| 0| 1| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.O%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  M  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  +     M  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     M  +  +  +     +  +  +  +  +  M  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  A  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  A  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  A  +     +  +  +  +  M  +  +  +        M  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     M  +  A  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Hepatocellular Carcinoma             |    X  X                       X  X           X                       X   |             
      Hepatocellular Carcinoma, Multiple   |                   X                                                      |             
      Hepatocellular Adenoma               |    X                                X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Squamous Cell Papilloma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                   +           +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M     M  M  M  M     +  M  M  M  M  M  +  +        M  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  M     +  +  +  M  M  +  +  +        +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 1| 7| 6| 3| 2| 1| 7| 7| 7| 7| 2| 7| 7| 4| 4| 1| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 3| 3| 3| 9| 3| 1| 0| 2| 9| 3| 3| 3| 3| 9| 3| 3| 8| 5| 8| 3| 3| 3| 3| 9|             
                                           | 8| 0| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 0| 0| 7| 1| 0| 4| 5| 9| 0| 0| 1| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.O%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                             +            |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  M     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                   +                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +     +  +                    +                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  M  +     +  +  +  +     +  M  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  M  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  I     +  +  M  A     +  M  +  +  M  +  +  M        M  +  +  M  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  M     M  M  M  M  M  M  M  M        M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  M  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                                         X                           |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                               X                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X                          X                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 1| 7| 6| 3| 2| 1| 7| 7| 7| 7| 2| 7| 7| 4| 4| 1| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 3| 3| 3| 9| 3| 1| 0| 2| 9| 3| 3| 3| 3| 9| 3| 3| 8| 5| 8| 3| 3| 3| 3| 9|             
                                           | 8| 0| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 0| 0| 7| 1| 0| 4| 5| 9| 0| 0| 1| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.O%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                            +                           |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
      Adenoma                              |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Adenocarcinoma                       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 1| 1| 7| 7| 6| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 4| 1| 7| 7| 4| 4| 1|             
                             DAY ON TEST   | 3| 3| 5| 8| 9| 3| 3| 0| 3| 5| 3| 0| 3| 3| 5| 7| 3| 3| 5| 8| 0| 3| 5| 5| 9|             
                                           | 0| 0| 5| 9| 0| 0| 0| 2| 1| 5| 1| 1| 1| 1| 5| 9| 1| 1| 5| 9| 8| 1| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.O%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +           +  +  +  +     +  +  +  +     +  +  +        M  +         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
      Adenocarcinoma                       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +           +  +  +  +     +  +  M  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
      Hepatocellular Carcinoma             |                         X              X                                 |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |                                                    X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | I  +           M  +  M  M     M  +  M  M     M  M  +        A  M         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +           +  +  +  +     +  M  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
      Follicular Cell, Adenoma             |                         X              X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 1| 1| 7| 7| 6| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 4| 1| 7| 7| 4| 4| 1|             
                             DAY ON TEST   | 3| 3| 5| 8| 9| 3| 3| 0| 3| 5| 3| 0| 3| 3| 5| 7| 3| 3| 5| 8| 0| 3| 5| 5| 9|             
                                           | 0| 0| 5| 9| 0| 0| 0| 2| 1| 5| 1| 1| 1| 1| 5| 9| 1| 1| 5| 9| 8| 1| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.O%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
                                            __________________________________________________________________________|             
   Penis                                   |                               +                             +            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +           +  +  +  I     +  +  +  M     +  +  +        +  +         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +           +  +  +  +     +  M  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +  +  +  +     +  +  +  +     M  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +           +  +  M  +     +  +  +  +     M  +  M        A  +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +           +  +  +  +     +  +  +  +     M  +  +        M  +         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                X                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +           +  +  +  +     +  +  +  +     +  +  +        M  +         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                X                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +           +  +  M  M     +  +  M  +     M  +  +        M  M         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M           M  M  M  M     M  M  M  M     M  M  M        M  M         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
      Squamous Cell Carcinoma              |                                  X                                       |             
      Subcutaneous Tissue, Fibrosarcoma    |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +           +  +  +  +     +  M  +  +     +  +  +        +  +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
      Alveolar/Bronchiolar Adenoma         | X                                                                        |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                X                                                         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +           +  +  +  +     +  M  +  +     +  +  +        +  +         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 1| 1| 7| 7| 6| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 4| 1| 7| 7| 4| 4| 1|             
                             DAY ON TEST   | 3| 3| 5| 8| 9| 3| 3| 0| 3| 5| 3| 0| 3| 3| 5| 7| 3| 3| 5| 8| 0| 3| 5| 5| 9|             
                                           | 0| 0| 5| 9| 0| 0| 0| 2| 1| 5| 1| 1| 1| 1| 5| 9| 1| 1| 5| 9| 8| 1| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.O%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                   +                          +                           |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
      Adenoma                              | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 4| 1| 1| 7| 7| 7| 4| 4| 7| 7| 7| 4| 1| 7| 5| 7| 7| 4|              |            |
                             DAY ON TEST   | 4| 3| 5| 9| 9| 3| 3| 3| 5| 4| 3| 3| 3| 0| 9| 3| 6| 3| 3| 5|              |            |
                                           | 5| 1| 5| 0| 0| 1| 1| 1| 6| 8| 1| 1| 1| 5| 0| 1| 7| 1| 1| 5|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    1.O%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +           +  +  +     +  +  +  +  +     +  M  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +           +  +  +     +  +  +  +  M     +  +  +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +           +  +  +     +  +  M  +  +     +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  45        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
      Hepatocellular Carcinoma             |                                                                          |          8 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                                              X                           |          4 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +           M                                 |   1        |
      Sarcoma                              |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +           +  +  +     +  +  +  +  +        +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                               +              +        +                  |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +           +  +  +     +  +  +  +  +     M  +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M           +  I  +     +  M  +  +  +     +  M  M  +                  |  20        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +           +  +  +     M  I  +  +  M     +  +  +  +                  |  40        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  66                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 4| 1| 1| 7| 7| 7| 4| 4| 7| 7| 7| 4| 1| 7| 5| 7| 7| 4|              |            |
                             DAY ON TEST   | 4| 3| 5| 9| 9| 3| 3| 3| 5| 4| 3| 3| 3| 0| 9| 3| 6| 3| 3| 5|              |            |
                                           | 5| 1| 5| 0| 0| 1| 1| 1| 6| 8| 1| 1| 1| 5| 0| 1| 7| 1| 1| 5|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    1.O%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                        +                                 |   4        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                  +           +                           |   6        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +           M  +  +     +  +  +  +  +     +  +  +  +                  |  45        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +           +  +  M     M  +  +  +  +     +  M  +  +                  |  40        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +           +  +  +     +  +  +  +  +     +  +  +  M                  |  45        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M           +  +  +     +  +  +  +  M     +  M  +  +                  |  29        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M           M  M  M     M  M  M  M  M     M  M  M  M                  |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +           +  +  +     +  +  M  +  +     +  +  +  +                  |  48        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                 X                        |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Alveolar/Bronchiolar Adenoma         |                      X                             X                     |          5 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  67                                                               
NTP Experiment-Test: 05057-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 10:46:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 4| 1| 1| 7| 7| 7| 4| 4| 7| 7| 7| 4| 1| 7| 5| 7| 7| 4|              |            |
                             DAY ON TEST   | 4| 3| 5| 9| 9| 3| 3| 3| 5| 4| 3| 3| 3| 0| 9| 3| 6| 3| 3| 5|              |            |
                                           | 5| 1| 5| 0| 0| 1| 1| 1| 6| 8| 1| 1| 1| 5| 0| 1| 7| 1| 1| 5|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    1.O%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M           +  +  +     +  +  +  +  +     +  +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   3        |
      Adenoma                              |                               X                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  68                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------