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TDMS Study 05058-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                             ROXARSONE


NTP Experiment-Test: 05058-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: DOSED FEED                                                                                                 Time: 08:59:01




       Facility:  Southern Research Institute

       Chemical CAS #:  121-19-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05058-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:59:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                     14           15           12                                                  
    Moribund Sacrifice                                21           17           21                                                  
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           18           17                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (45)         (47)                                                
   Intestine Small, Duodenum                          (47)         (50)         (46)                                                
      Adenoma                                          1 (2%)                                                                       
   Intestine Small, Ileum                             (46)         (49)         (47)                                                
   Intestine Small, Jejunum                           (49)         (50)         (46)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                           1 (2%)                                                                       
      Sarcoma                                                                    1 (2%)                                             
   Mesentery                                          (27)         (27)         (30)                                                
      Sarcoma                                                                    1 (3%)                                             
   Pancreas                                           (50)         (50)         (49)                                                
   Salivary Glands                                    (48)         (49)         (47)                                                
   Stomach, Glandular                                 (50)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
   Adrenal Gland, Medulla                             (50)         (49)         (50)                                                
   Islets, Pancreatic                                 (50)         (50)         (49)                                                
      Adenoma                                          1 (2%)                                                                       
   Parathyroid Gland                                  (46)         (44)         (47)                                                
   Pituitary Gland                                    (49)         (46)         (49)                                                
      Pars Distalis, Adenoma                           6 (12%)      3 (7%)       4 (8%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 05058-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:59:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Intermedia, Adenoma                                                   2 (4%)                                             
   Thyroid Gland                                      (49)         (49)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (49)         (50)                                                
      Luteoma                                          1 (2%)                                                                       
      Sarcoma                                                                    1 (2%)                                             
   Uterus                                             (50)         (50)         (50)                                                
      Adenocarcinoma                                                1 (2%)                                                          
      Hemangioma, Multiple                                          1 (2%)                                                          
      Leiomyoma                                                                  1 (2%)                                             
      Sarcoma                                                                    1 (2%)                                             
      Cervix, Polyp Stromal                                         1 (2%)                                                          
      Endometrium, Polyp Stromal                       1 (2%)                    1 (2%)                                             
   Vagina                                                                       (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
      Renal, Sarcoma                                                             1 (2%)                                             
   Lymph Node, Mandibular                             (40)         (48)         (42)                                                
   Lymph Node, Mesenteric                             (48)         (48)         (46)                                                
   Spleen                                             (50)         (50)         (49)                                                
   Thymus                                             (39)         (42)         (44)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
      Adenocarcinoma, Multiple                         1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)                                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Trichoepithelioma                                             1 (2%)                                                          
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05058-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:59:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (6)          (2)          (2)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
   Spinal Cord                                        (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)       3 (6%)       3 (6%)                                             
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       1 (2%)       2 (4%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (3)          (3)                                                 
      Adenoma                                          1 (50%)      2 (67%)      1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Sarcoma                                                                    1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   1 (2%)       1 (2%)       1 (2%)                                             
      Lymphoma Malignant Mixed                        12 (24%)      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05058-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:59:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            24          11          18                                                   
     Total Primary Neoplasms                           32          16          25                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 11           9          13                                                   
     Total Benign Neoplasms                            13          12          13                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18           3           5                                                   
     Total Malignant Neoplasms                         19           4          12                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      1                                                   
     Total Metastatic Neoplasm                                                  1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05058-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:59:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17            9           11                                                  
    Natural Death                                      6            1            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           40           33                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (42)         (48)                                                
      Adenocarcinoma, Metastatic                                                 1 (2%)                                             
   Intestine Large, Cecum                             (50)         (49)         (49)                                                
   Intestine Small, Duodenum                          (49)         (45)         (47)                                                
   Intestine Small, Jejunum                           (49)         (49)         (48)                                                
   Liver                                              (50)         (50)         (50)                                                
      Adenocarcinoma, Metastatic                                                 1 (2%)                                             
      Adenoma, Multiple                                                          1 (2%)                                             
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatocellular Carcinoma                         3 (6%)       8 (16%)      5 (10%)                                            
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                           9 (18%)      8 (16%)      2 (4%)                                             
   Mesentery                                          (4)          (4)          (6)                                                 
      Adenocarcinoma, Metastatic                                                 1 (17%)                                            
   Pancreas                                           (49)         (50)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (49)                                                
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Subcapsular, Adenoma                                          1 (2%)       3 (6%)                                             
   Adrenal Gland, Medulla                             (50)         (50)         (49)                                                
      Pheochromocytoma NOS                                                       1 (2%)                                             
      Pheochromocytoma Benign                          3 (6%)                                                                       
                                                             Page   6                                                               
NTP Experiment-Test: 05058-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:59:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (50)         (48)         (50)                                                
      Follicular Cell, Adenoma                                      2 (4%)       2 (4%)                                             
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ductus Deferens                                    (2)                                                                           
   Preputial Gland                                    (11)         (13)         (7)                                                 
      Carcinoma                                        1 (9%)                                                                       
   Prostate                                           (50)         (50)         (49)                                                
   Seminal Vesicle                                    (2)          (3)          (2)                                                 
   Testes                                             (50)         (50)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Interstitial Cell, Adenoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
   Lymph Node                                         (50)         (49)         (50)                                                
      Axillary, Sarcoma, Metastatic, Skin              1 (2%)                                                                       
      Inguinal, Sarcoma, Metastatic, Skin                           1 (2%)                                                          
      Inguinal, Lumbar, Sarcoma, Metastatic, Skin                   1 (2%)                                                          
      Mediastinal, Adenocarcinoma, Metastatic                                    1 (2%)                                             
   Lymph Node, Mandibular                             (48)         (42)         (43)                                                
   Lymph Node, Mesenteric                             (43)         (48)         (47)                                                
   Spleen                                             (50)         (50)         (50)                                                
      Hemangiosarcoma                                  2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)                                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Abdominal, Axillary, Subcutaneous Tissue,                                                                                     
           Sarcoma, Multiple, Metastatic, Skin                      1 (2%)                                                          
      Hindlimb, Subcutaneous Tissue, Sarcoma                        1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     4 (8%)       4 (8%)       4 (8%)                                             
      Subcutaneous Tissue, Fibrosarcoma                6 (12%)      3 (6%)       7 (14%)                                            
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
                                                             Page   7                                                               
NTP Experiment-Test: 05058-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:59:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Sarcoma                     4 (8%)       4 (8%)       5 (10%)                                            
      Subcutaneous Tissue, Sarcoma, Multiple           1 (2%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Schwannoma NOS              2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Pelvis, Osteoma                                               1 (2%)                                                          
   Skeletal Muscle                                    (1)          (2)          (2)                                                 
      Abdominal, Thoracic, Adenocarcinoma,                                                                                          
          Multiple, Metastatic                                                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                   (50)         (50)         (50)                                                
      Sciatic, Sarcoma, Metastatic, Skin                            1 (2%)                                                          
   Spinal Cord                                        (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenocarcinoma, Metastatic                                                 1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     4 (8%)       2 (4%)       9 (18%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   6 (12%)      2 (4%)       1 (2%)                                             
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Liver                            1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)                    1 (2%)                                             
      Sarcoma, Metastatic, Skin                                     1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
      Squamous Cell Carcinoma, Multiple,                                                                                            
          Metastatic, Skin                             1 (2%)                                                                       
   Nose                                               (48)         (49)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (5)          (6)          (4)                                                 
      Adenoma                                          1 (20%)      2 (33%)      3 (75%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05058-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:59:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Adenocarcinoma, Metastatic                                                 1 (2%)                                             
   Ureter                                                          (1)                                                              
      Transitional Epithelium, Carcinoma                            1 (100%)                                                        
   Urinary Bladder                                    (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                   2 (4%)                                                                       
      Lymphoma Malignant Mixed                         3 (6%)       1 (2%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05058-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:59:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          30          34                                                   
     Total Primary Neoplasms                           57          45          51                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 18          20          20                                                   
     Total Benign Neoplasms                            23          24          26                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          18          21                                                   
     Total Malignant Neoplasms                         32          21          23                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           2           2                                                   
     Total Metastatic Neoplasm                          6           5           9                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  2                       2                                                   
     Total Uncertain Neoplasms                          2                       2                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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