National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2415

TDMS Study 05058-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                             ROXARSONE


NTP Experiment-Test: 05058-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: DOSED FEED                                                                                                 Time: 07:31:54




       Facility:  Southern Research Institute

       Chemical CAS #:  121-19-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05058-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                22           12           16                                                  
    Natural Death                                      1            3            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           35           32                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (50)         (50)                                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Neoplastic Nodule                                             1 (2%)                                                          
   Mesentery                                          (10)         (6)          (3)                                                 
   Pancreas                                           (50)         (50)         (50)                                                
   Pharynx                                            (2)                       (1)                                                 
      Squamous Cell Papilloma                          1 (50%)                                                                      
   Salivary Glands                                    (50)         (47)         (48)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Tongue                                                                       (2)                                                 
      Squamous Cell Papilloma                                                    1 (50%)                                            
   Tooth                                                           (2)          (1)                                                 
      Gingiva, Basosquamous Tumor Malignant                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (49)         (48)         (50)                                                
      Pheochromocytoma Benign                                       1 (2%)       2 (4%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)       2 (4%)                                                          
   Pituitary Gland                                    (50)         (49)         (48)                                                
      Pars Distalis, Adenoma                          27 (54%)     28 (57%)     18 (38%)                                            
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)                                                
                                                             Page   2                                                               
NTP Experiment-Test: 05058-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Adenoma                                  8 (16%)      5 (10%)      8 (16%)                                            
      C-Cell, Adenoma, Multiple                                     1 (2%)       1 (2%)                                             
      C-Cell, Carcinoma                                2 (4%)       4 (8%)       1 (2%)                                             
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (44)         (47)         (48)                                                
      Adenoma                                          1 (2%)       3 (6%)       5 (10%)                                            
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)                                             
      Bilateral, Adenoma                                                         1 (2%)                                             
   Ovary                                              (50)         (47)         (50)                                                
   Uterus                                             (50)         (49)         (50)                                                
      Adenocarcinoma                                   1 (2%)       2 (4%)       1 (2%)                                             
      Polyp Stromal                                    8 (16%)     18 (37%)     12 (24%)                                            
      Polyp Stromal, Multiple                          2 (4%)                                                                       
      Sarcoma Stromal                                                            1 (2%)                                             
      Schwannoma Malignant                                                       1 (2%)                                             
      Cervix, Polyp                                                              1 (2%)                                             
      Cervix, Squamous Cell Carcinoma                                            1 (2%)                                             
   Vagina                                                                       (3)                                                 
      Polyp                                                                      1 (33%)                                            
      Sarcoma                                                                    1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                       (2)                                                 
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
   Lymph Node, Mandibular                             (49)         (46)         (49)                                                
   Lymph Node, Mesenteric                             (50)         (50)         (46)                                                
   Spleen                                             (50)         (50)         (50)                                                
   Thymus                                             (50)         (42)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05058-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (50)                                                
      Adenocarcinoma                                   4 (8%)                    1 (2%)                                             
      Fibroadenoma                                    16 (32%)     16 (33%)     17 (34%)                                            
      Fibroadenoma, Multiple                           5 (10%)      1 (2%)       4 (8%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Adenoma                                            1 (2%)                                                          
      Basal Cell Adenoma, Multiple                                               1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                               1 (2%)                                             
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Benign           1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteosarcoma                                                               2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
   Spinal Cord                                        (50)         (50)         (49)                                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                                               1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)          (1)                                                 
      Carcinoma                                                     1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05058-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Squamous Cell Carcinoma, Metastatic                                        1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            14 (28%)     12 (24%)     11 (22%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05058-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          47          46                                                   
     Total Primary Neoplasms                          100          98         100                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 44          44          42                                                   
     Total Benign Neoplasms                            74          77          77                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          20          20                                                   
     Total Malignant Neoplasms                         26          21          23                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       2                                                   
     Total Metastatic Neoplasm                          4                       2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05058-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                22           25           27                                                  
    Natural Death                                      4            7            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           18           18                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (50)         (50)         (50)                                                
      Adenocarcinoma                                                1 (2%)                                                          
      Leiomyosarcoma                                                2 (4%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Hepatocellular Carcinoma                         2 (4%)                    1 (2%)                                             
      Neoplastic Nodule                                             2 (4%)                                                          
   Mesentery                                          (2)          (4)          (6)                                                 
   Pancreas                                           (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)       1 (2%)       5 (10%)                                            
   Pharynx                                            (2)                       (1)                                                 
      Squamous Cell Papilloma                          2 (100%)                  1 (100%)                                           
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (49)         (50)                                                
      Pheochromocytoma Malignant                       4 (8%)       4 (8%)       3 (6%)                                             
      Pheochromocytoma Malignant, Multiple             1 (2%)                    1 (2%)                                             
      Pheochromocytoma Benign                         15 (30%)      9 (18%)     10 (20%)                                            
                                                             Page   7                                                               
NTP Experiment-Test: 05058-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign, Multiple                             5 (10%)      6 (12%)                                            
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                                       3 (6%)       4 (8%)                                             
      Carcinoma                                        2 (4%)       1 (2%)                                                          
   Parathyroid Gland                                  (46)         (47)         (45)                                                
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (50)         (48)         (48)                                                
      Craniopharyngioma                                                          1 (2%)                                             
      Pars Distalis, Adenoma                           6 (12%)     13 (27%)      8 (17%)                                            
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  4 (8%)       2 (4%)       3 (6%)                                             
      C-Cell, Carcinoma                                1 (2%)       2 (4%)       2 (4%)                                             
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
   Preputial Gland                                    (49)         (48)         (48)                                                
      Adenoma                                          7 (14%)      3 (6%)       2 (4%)                                             
      Carcinoma                                                     4 (8%)                                                          
   Prostate                                           (50)         (50)         (50)                                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Seminal Vesicle                                    (3)          (5)          (3)                                                 
   Testes                                             (50)         (50)         (50)                                                
      Interstitial Cell, Adenoma                       4 (8%)       1 (2%)       9 (18%)                                            
      Interstitial Cell, Adenoma, Multiple            42 (84%)     47 (94%)     34 (68%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                           (2)          (1)                                                 
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
      Mediastinal, Sarcoma                                          1 (2%)                                                          
   Lymph Node, Mandibular                             (50)         (50)         (48)                                                
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (49)         (48)                                                
   Spleen                                             (50)         (50)         (50)                                                
      Sarcoma                                                                    1 (2%)                                             
   Thymus                                             (49)         (49)         (47)                                                
                                                             Page   8                                                               
NTP Experiment-Test: 05058-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (49)         (49)                                                
      Fibroadenoma                                     2 (4%)                    3 (6%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Carcinoma                                          1 (2%)                                                          
      Fibroma                                                                    1 (2%)                                             
      Hemangioma                                       1 (2%)                                                                       
      Keratoacanthoma                                  4 (8%)       4 (8%)       4 (8%)                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                                                    2 (4%)                                             
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)       3 (6%)                                             
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteosarcoma                                     3 (6%)                                                                       
   Skeletal Muscle                                    (1)                       (2)                                                 
      Osteosarcoma, Metastatic, Bone                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)                                                
      Astrocytoma Malignant                                         1 (2%)                                                          
      Schwannoma Malignant                                          1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Skin        1 (2%)                                                                       
      Cerebellum, Granular Cell Tumor NOS                                        1 (2%)                                             
   Spinal Cord                                        (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)       2 (4%)                                                          
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                   2 (4%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Skin        1 (2%)                                                                       
   Nose                                               (49)         (50)         (49)                                                
      Respiratory Epithelium, Adenoma                                            1 (2%)                                             
                                                             Page   9                                                               
NTP Experiment-Test: 05058-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (2)          (1)          (1)                                                 
      Adenoma                                          1 (50%)                   1 (100%)                                           
      Carcinoma                                        1 (50%)      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Renal Tubule, Adenoma                            1 (2%)       2 (4%)       1 (2%)                                             
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            27 (54%)     28 (56%)     25 (50%)                                            
      Mesothelioma Malignant                           1 (2%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05058-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          50                                                   
     Total Primary Neoplasms                          141         146         139                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          50          50                                                   
     Total Benign Neoplasms                            95          96         101                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              36          35          33                                                   
     Total Malignant Neoplasms                         46          50          37                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           2           1                                                   
     Total Metastatic Neoplasm                          8           4           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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