National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2284

TDMS Study 05063-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           PHENYLBUTAZONE


NTP Experiment-Test: 05063-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: GAVAGE                                                                                                     Time: 21:11:03




       Facility:  TSI Mason Research

       Chemical CAS #:  50-33-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05063-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:11:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           11            5                                                  
    Natural Death                                      8            9           12                                                  
    Dead                                                            1                                                               
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           29           32                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (44)         (28)         (47)                                                
   Intestine Large, Cecum                             (50)         (8)          (40)                                                
   Intestine Small, Ileum                             (46)         (15)         (44)                                                
   Intestine Small, Jejunum                           (49)         (15)         (45)                                                
   Liver                                              (50)         (49)         (50)                                                
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Adenoma                           3 (6%)       4 (8%)       4 (8%)                                             
      Hepatocellular Adenoma, Multiple                 1 (2%)       1 (2%)       3 (6%)                                             
   Mesentery                                          (9)          (8)          (4)                                                 
      Fibrosarcoma, Metastatic, Skin                                             1 (25%)                                            
      Sarcoma, Metastatic, Skin                        1 (11%)                                                                      
   Pancreas                                           (50)         (19)         (49)                                                
   Pharynx                                                                      (1)                                                 
   Salivary Glands                                    (48)         (16)         (49)                                                
   Stomach, Forestomach                               (50)         (16)         (48)                                                
      Squamous Cell Carcinoma, Early Invasion          2 (4%)                                                                       
      Squamous Cell Papilloma                          3 (6%)                    2 (4%)                                             
   Stomach, Glandular                                 (49)         (16)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (16)         (50)                                                
      Carcinoma, Metastatic, Lung                                   1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05063-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:11:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (48)         (15)         (49)                                                
   Adrenal Gland, Cortex                              (48)         (15)         (49)                                                
   Adrenal Gland, Medulla                             (47)         (15)         (48)                                                
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Pituitary Gland                                    (44)         (17)         (47)                                                
      Pars Distalis, Adenoma                           8 (18%)      5 (29%)      3 (6%)                                             
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
   Thyroid Gland                                      (48)         (14)         (50)                                                
      Follicular Cell, Adenoma                         2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (47)         (47)                                                
      Cystadenoma                                                   1 (2%)                                                          
      Granulosa Cell Tumor Benign                                   1 (2%)       1 (2%)                                             
      Luteoma                                          1 (2%)                                                                       
   Uterus                                             (50)         (49)         (48)                                                
      Adenocarcinoma                                                2 (4%)                                                          
      Hemangioma                                                                 1 (2%)                                             
      Leiomyoma                                        1 (2%)                    1 (2%)                                             
      Polyp Stromal                                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (15)         (50)                                                
      Sternal, Sarcoma, Metastatic, Skin               1 (2%)                                                                       
   Lymph Node                                         (47)         (24)         (48)                                                
      Inguinal, Carcinoma, Metastatic, Lung                         1 (4%)                                                          
      Lumbar, Adenocarcinoma, Metastatic, Uterus                    1 (4%)                                                          
      Mediastinal, Sarcoma, Metastatic, Skin           1 (2%)                                                                       
   Lymph Node, Mandibular                             (34)         (12)         (30)                                                
   Lymph Node, Mesenteric                             (42)         (18)         (41)                                                
   Spleen                                             (50)         (29)         (49)                                                
      Hemangiosarcoma                                               1 (3%)                                                          
   Thymus                                             (37)         (11)         (39)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05063-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:11:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (31)         (5)          (23)                                                
      Adenocarcinoma                                                             1 (4%)                                             
   Skin                                               (49)         (16)         (48)                                                
      Hemangioma                                       1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                             1 (6%)       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (16)         (50)                                                
      Carcinoma, Metastatic, Lung                                   1 (6%)                                                          
      Sternum, Fibrosarcoma, Deep Invasion                          1 (6%)                                                          
   Skeletal Muscle                                    (2)          (4)          (4)                                                 
      Sarcoma, Extension                               1 (50%)                                                                      
      Hindlimb, Carcinoma, Metastatic, Lung                         1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (16)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (21)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     3 (6%)       2 (10%)      3 (6%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (5%)                                                          
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Nose                                               (50)         (12)         (41)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (1)          (1)                                                 
      Adenoma                                          1 (50%)                                                                      
   Lacrimal Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Lung                                   1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
   Ureter                                                          (1)                                                              
                                                             Page   4                                                               
NTP Experiment-Test: 05063-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:11:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
   Urinary Bladder                                    (50)         (16)         (48)                                                
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia                                                      1 (2%)                                                          
      Leukemia Granulocytic                                                      1 (2%)                                             
      Lymphoma Malignant                               1 (2%)                                                                       
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   2 (4%)       1 (2%)                                                          
      Lymphoma Malignant Mixed                         2 (4%)       5 (10%)      4 (8%)                                             
      Lymphoma Malignant Undifferentiated Cell         7 (14%)      2 (4%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05063-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:11:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            31          20          25                                                   
     Total Primary Neoplasms                           43          30          31                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 20          13          15                                                   
     Total Benign Neoplasms                            24          15          19                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          12          12                                                   
     Total Malignant Neoplasms                         19          15          12                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           1                                                   
     Total Metastatic Neoplasm                          4           6           3                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05063-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:11:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12            6           11                                                  
    Natural Death                                      2            2            3                                                  
    Accident                                                        2                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           40           36                                                  
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (49)         (5)          (50)                                                
   Intestine Small, Ileum                             (49)         (9)          (50)                                                
   Intestine Small, Jejunum                           (49)         (3)          (49)                                                
   Liver                                              (50)         (50)         (50)                                                
      Adenoma, Multiple                                                          1 (2%)                                             
      Hemangiosarcoma                                               2 (4%)                                                          
      Hepatocellular Carcinoma                         8 (16%)      3 (6%)      11 (22%)                                            
      Hepatocellular Carcinoma, Multiple                            1 (2%)                                                          
      Hepatocellular Adenoma                           6 (12%)      9 (18%)     15 (30%)                                            
      Hepatocellular Adenoma, Multiple                 2 (4%)       3 (6%)       8 (16%)                                            
   Salivary Glands                                    (50)         (4)          (50)                                                
      Hepatocellular Carcinoma, Metastatic                                       1 (2%)                                             
   Stomach, Forestomach                               (48)         (5)          (50)                                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (48)         (5)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (5)          (50)                                                
      Hepatocellular Carcinoma, Metastatic                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (8)          (48)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (47)         (5)          (45)                                                
      Pars Distalis, Adenoma                           1 (2%)                    1 (2%)                                             
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05063-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:11:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (48)         (5)          (49)                                                
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)          (1)          (11)                                                
      Adenocarcinoma                                   1 (100%)                                                                     
   Preputial Gland                                    (10)         (14)         (8)                                                 
      Basosquamous Tumor NOS                           1 (10%)                                                                      
      Squamous Cell Carcinoma                                       1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (27)         (50)                                                
   Lymph Node, Mandibular                             (27)         (1)          (23)                                                
   Lymph Node, Mesenteric                             (45)         (20)         (47)                                                
   Spleen                                             (50)         (20)         (50)                                                
      Hemangiosarcoma                                               1 (5%)                                                          
   Thymus                                             (41)         (4)          (34)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (11)         (49)                                                
      Squamous Cell Carcinoma                                       1 (9%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (9%)       2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma                3 (6%)       2 (18%)      7 (14%)                                            
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (33)         (50)                                                
      Scapula, Osteosarcoma                            1 (2%)                                                                       
   Skeletal Muscle                                    (2)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05063-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:11:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (5)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (14)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     5 (10%)      5 (36%)      4 (8%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (7%)                                                          
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic             4 (8%)                    4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)                                                              
      Fibrosarcoma                                     1 (100%)                                                                     
   Eye                                                (2)                                                                           
      Lids, Fibrosarcoma, Metastatic, Ear              1 (50%)                                                                      
   Harderian Gland                                    (3)          (2)          (3)                                                 
      Adenoma                                          2 (67%)      1 (50%)      1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
      Renal Tubule, Hepatocellular Carcinoma,                                                                                       
          Metastatic                                                             1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant                               1 (2%)                                                                       
      Lymphoma Malignant Histiocytic                   2 (4%)       1 (2%)                                                          
      Lymphoma Malignant Mixed                         1 (2%)       4 (8%)       1 (2%)                                             
      Lymphoma Malignant Undifferentiated Cell         3 (6%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05063-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:11:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            30          28          40                                                   
     Total Primary Neoplasms                           42          39          57                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 17          17          30                                                   
     Total Benign Neoplasms                            20          20          35                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          17          21                                                   
     Total Malignant Neoplasms                         21          19          22                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5                       4                                                   
     Total Metastatic Neoplasm                          5                       7                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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