National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2288

TDMS Study 05063-02 Pathology Tables

NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97
Route: GAVAGE                                                                                                     Time: 08:17:42




       Facility:  TSI Mason Research

       Chemical CAS #:  50-33-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|             
                                           | 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Inflammation, Acute                  | 1                                                                        |             
      Inflammation, Chronic                |                                              1           2  1  1         |             
      Inflammation, Chronic Active         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic Active |    2                                         2                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelium, Hyperplasia             |                                                                          |             
      Muscularis, Inflammation, Chronic    |                                                                          |             
          Active                           |                                              2                           |             
      Serosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Mesothelium, Hyperplasia             |                                                                          |             
      Serosa, Fibrosis                     |                                                          2               |             
      Serosa, Inflammation, Chronic Active |                                                          2               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +|             
      Lymphoid Nodule, Hyperplasia         |                                                          2               |             
      Mesothelium, Hyperplasia             |                                                                          |             
      Mucosa, Vacuolization Cytoplasmic    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelium, Hyperplasia             |                                                                          |             
      Serosa, Inflammation, Chronic Active |    1                                         2                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                            1                                             |             
      Congestion                           |                                                          2               |             
      Eosinophilic Focus                   |                               1                                          |             
      Fatty Change                         |                      2           2                 2                     |             
      Hematopoietic Cell Proliferation     | 1  3  1  2           2              2        2  3  3     3        2      |             
      Inflammation, Acute                  |    2                                                                     |             
      Inflammation, Chronic                |                                                             2  1         |             
      Inflammation, Chronic Active         |                            1                                             |             
      Necrosis, Coagulative                |                            1     3           2              1  1         |             
      Vacuolization Cytoplasmic, Diffuse   |                                        4                                 |             
      Periportal, Inflammation, Chronic    | 2     1  1        1  2              1                 1           2  1   |             
      Serosa, Inflammation, Acute          | 1  1                                                              2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +        +                 +                     |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|             
                                           | 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                  2                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1                    2                                          |             
      Fatty Change                         |                                                                          |             
      Fibrosis                             |                               4                                          |             
      Inflammation, Acute                  |    2                                                                     |             
      Inflammation, Chronic                |                   1     1  1              1              1  1  1     1   |             
      Inflammation, Chronic Active         |          2                    4              1  2                        |             
      Duct, Dilatation                     |                                                                          |             
      Serosa, Fibrosis                     |                                                                          |             
      Serosa, Inflammation, Acute          |                                                                   2      |             
      Serosa, Inflammation, Chronic Active | 1                                                  2                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Parotid Gland, Inflammation, Chronic |                                           1                    1         |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |    1                                                                     |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |    1              1  1     1        1           1  1  1     1  2     1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                   2      |             
      Hyperkeratosis                       |                                                                   2      |             
      Inflammation, Chronic                |                                                       1           2      |             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Chronic                |    1     1  1           1                 1  1                    2      |             
      Inflammation, Chronic Active         |                   2                                            1     2   |             
      Epithelium, Hyperplasia, Focal       |                                                    2                     |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +     +  +     +     +  +  +     +     +  +  +     +  +  +  +  +      |             
      Dysplasia                            |                                                                          |             
      Incisor, Abscess                     | 3                                   2                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Bacterium                            |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |             1                                                            |             
      Inflammation, Acute                  |                                                    4                     |             
      Inflammation, Chronic                |       1                             1        1                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Coronary Artery, Perivascular,       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|             
                                           | 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Inflammation, Acute              |                                                                          |             
      Coronary Artery, Perivascular,       |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Inflammation, Chronic Active| 2  1     2                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |    2                                                                     |             
      Hematopoietic Cell Proliferation     | 1                                                        1               |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |    1                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  +  +  M  M  +  M  +  +  +  M  +  +  M  +  +  +  M  +  M  +  M|             
      Cyst                                 |                2                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Congestion            |                                                                          |             
      Pars Distalis, Cyst                  |                                                    X                     |             
      Pars Distalis, Hyperplasia           | 3  3  2        2  1           3              3           3               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ultimobranchial Cyst                 |    1                                                                     |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                         2                                                |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              | 4  4  4  4                          4        4  4  4     4        4      |             
      Cyst                                 |             2                 2                    X           3        4|             
      Hemorrhage                           |             2                                                            |             
      Mineralization                       |                                           1                              |             
      Periovarian Tissue, Cyst             |                         3                             3                  |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                            1                          2     2  2     2   |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  |                                              3                           |             
      Serosa, Inflammation, Chronic Active |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|             
                                           | 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |    +                                                           +         |             
      Inflammation, Acute, Hemorrhagic     |                                                                          |             
      Inflammation, Acute                  |    2                                                           2         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |       4                                                                  |             
      Hydrometra                           | 2                                                                        |             
      Inflammation, Acute                  | 2        1           3              2     1     2        2        2      |             
      Inflammation, Chronic                |                            1                                             |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Hyperplasia             | 2  3  2  2  3  2  2  4  2  2  3  2  3  2  2  2  2  3  3  2  2  3  2  4  3|             
      Muscularis, Congestion               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Myelofibrosis                        | 2        2  3  2  2  1  2  2  3     2  2  2  1  1     2  1  3  2     2  1|             
      Myeloid Cell, Hyperplasia            |       4                             4              4                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Bacterium                    |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |       2  4                          4           2                        |             
      Lumbar, Inflammation, Chronic Active |       2     1                                                            |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Depletion Lymphoid      |                                                                          |             
      Mediastinal, Hemorrhage              |                2        1                                                |             
      Mediastinal, Hyperplasia, Lymphoid   |                   2                                                      |             
      Mediastinal, Hyperplasia, Plasma Cell|    4  2  3                                   3     4                     |             
      Mediastinal, Inflammation, Acute     |                                              3                           |             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Hyperplasia, Plasma Cell |                                                          2               |             
      Pancreatic, Inflammation, Acute      |                                                          1               |             
      Renal, Bacterium                     |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      | 3     2  4                          3        3  2                        |             
      Renal, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  M  +  +  M  +  +|             
      Depletion Lymphoid                   |                                              2                           |             
      Hyperplasia, Plasma Cell             |                                        1                                 |             
      Inflammation, Acute                  | 1                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2              1  1     1   |             
      Congestion                           |                                           1                              |             
      Depletion Lymphoid                   |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|             
                                           | 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                  3                                       |             
      Hyperplasia, Histiocytic             |                                              2                           |             
      Hyperplasia, Lymphoid                |                                                 2                        |             
      Hyperplasia, Plasma Cell             | 2                                                        2               |             
      Inflammation, Acute                  | 1                                                        1               |             
      Inflammation, Chronic Active         |                                                                          |             
      Serosa, Congestion                   |                                                                          |             
      Serosa, Fibrosis                     |                         2                                                |             
      Serosa, Inflammation, Chronic Active | 2                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Depletion Lymphoid                   |                                              3     3                     |             
      Hematopoietic Cell Proliferation     | 3  4  4  2           2              3  2     4  2  4     2        3      |             
      Hemorrhage                           |                                           4                              |             
      Hyperplasia, Lymphoid                |                               3                             2        2   |             
      Necrosis, Coagulative                |                                              2                           |             
      Capsule, Abscess                     |    4                                                                     |             
      Capsule, Fibrosis                    |    4                                                                     |             
      Capsule, Inflammation, Acute         |          1                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  M  M  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Depletion Lymphoid                   |    2                                   3     3     4                     |             
      Hemorrhage                           |                                                                1         |             
      Inflammation, Acute                  |    2                                         2                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  +  M  +  +  +  +  +  M  M  M  M  +  +  M  +  +  +  +  +  M  +|             
      Galactocele                          |                                                                2         |             
      Hyperplasia                          |                            1                                             |             
      Infiltration Cellular, Mixed Cell    | 1                                                                        |             
      Inflammation, Chronic                |                                                       1        1         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                                  4                                       |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Hemorrhage                           |                         3                                                |             
      Infarct, Multifocal                  |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|             
                                           | 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Thalamus, Mineralization             |    1     1  1  1  1  1        1        1  1  1     1  1  1  1  1  1  1   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           | 1                 1     1                    1                           |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Leukocytosis                         |                                                                   4      |             
      Artery, Hyperplasia                  |                                                                          |             
      Artery, Thrombosis                   |                                  1                                       |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Perivascular, Inflammation, Acute    |                                                    4                     |             
      Perivascular, Inflammation, Chronic  |                            2                                             |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
      Pleura, Inflammation, Acute          |                                                    3                     |             
      Pleura, Inflammation, Chronic        |                                                                          |             
      Pleura, Inflammation, Chronic Active,|                                                                          |             
           Hemorrhagic                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Inflammation, Acute           | 1                                                     2        2         |             
      Mucosa, Glands, Inflammation, Acute  |    1     1              1  1                             1  1  2     1   |             
      Mucosa, Glands, Inflammation,        |                                                                          |             
          Chronic Active                   |                   1                                                      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                      2                             2           1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|             
                                           | 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Bacterium                            |                                                                          |             
      Glomerulosclerosis                   | 2        3     4                             2  2        3        4      |             
      Inflammation, Chronic                | 2  1  2  2  1     1  3  1  2  1     2  1  2  2  2  1  1  2  2  2  1  2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |             1                                                            |             
      Necrosis, Coagulative, Focal         |                                                                          |             
      Capsule, Inflammation, Acute         |                                              1                           |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Atrophy                         | 2                                                                        |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Regeneration                    |       1                                1  1     1                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                           1                              |             
      Inflammation, Chronic                | 1  1     1  2     1  2  1  1  1              1  1     1  1  1  1  1  1   |             
      Inflammation, Chronic Active         |       2                                                                  |             
      Serosa, Inflammation, Acute          |                                              1                           |             
      Serosa, Inflammation, Chronic Active |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3|            |
                                           | 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Inflammation, Acute                  |    3                                            3                 3      |      4  2.5|
      Inflammation, Chronic                |                         1                          1                    1|      7  1.1|
      Inflammation, Chronic Active         |       1                                                                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Serosa, Inflammation, Chronic Active |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelium, Hyperplasia             |       1                                                                  |      1  1.0|
      Muscularis, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Serosa, Inflammation, Acute          |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Serosa, Inflammation, Acute          |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Mesothelium, Hyperplasia             |       1                                                                  |      1  1.0|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
      Serosa, Inflammation, Chronic Active |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
      Lymphoid Nodule, Hyperplasia         |                               2        2                                 |      3  2.0|
      Mesothelium, Hyperplasia             |       1                                         1                        |      2  1.0|
      Mucosa, Vacuolization Cytoplasmic    |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Mesothelium, Hyperplasia             |       1  1                                      1                        |      3  1.0|
      Serosa, Inflammation, Chronic Active |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      1  1.0|
      Congestion                           |       1                                                                  |      2  1.5|
      Eosinophilic Focus                   |                                                                          |      1  1.0|
      Fatty Change                         |                      2                       1                           |      5  1.8|
      Hematopoietic Cell Proliferation     |    3  2  3  3                                   3                 2  1  1|     19  2.2|
      Inflammation, Acute                  |    3  2                                                                  |      3  2.3|
      Inflammation, Chronic                |                      1  1        2     1        2  1  1     1  1        1|     12  1.3|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Necrosis, Coagulative                |                                        1                    1  1         |      8  1.4|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  4.0|
      Periportal, Inflammation, Chronic    | 1        1  1  1           1  1     1        1           1  1            |     19  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3|            |
                                           | 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Serosa, Inflammation, Acute          |                                                 3                 3      |      5  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +  +  +                    +              +                        |   9        |
      Inflammation, Acute                  |             3                                                            |      1  3.0|
      Inflammation, Chronic                |                                  2                                       |      1  2.0|
      Inflammation, Chronic Active         |    3  2  3                                      2                        |      5  2.6|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      2  1.5|
      Fatty Change                         |                1                                                         |      1  1.0|
      Fibrosis                             |                                                                          |      1  4.0|
      Inflammation, Acute                  |       2                                                                  |      2  2.0|
      Inflammation, Chronic                |                         1  1     1     1     1     1  1              1  1|     17  1.0|
      Inflammation, Chronic Active         |                               2                                          |      5  2.2|
      Duct, Dilatation                     |                               4                                          |      1  4.0|
      Serosa, Fibrosis                     |    3  3                                                                  |      2  3.0|
      Serosa, Inflammation, Acute          |    3     2  3                                                     4      |      5  2.8|
      Serosa, Inflammation, Chronic Active |                                                 1                        |      3  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Parotid Gland, Inflammation, Chronic |                                                                          |      2  1.0|
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic                          |                                              1                       1   |      3  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         | 1  1     1     2        1  1  1        1     1  1  1     1  1        2  1|     26  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                      2  2                                                |      3  2.0|
      Hyperkeratosis                       |                      2  2                                      2         |      4  2.0|
      Inflammation, Chronic                |                         2                                                |      3  1.7|
      Inflammation, Chronic Active,        |                                                                          |            |
          Necrotizing                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |       1  1  1                                         1              1  1|     13  1.1|
      Inflammation, Chronic Active         |    1                          2                                          |      5  1.6|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +  +  +  +           +  +  +  +     +     +  +  +  +     +  +  +  +  +|  35        |
      Dysplasia                            |                            3                                             |      1  3.0|
      Incisor, Abscess                     |                         1                                                |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3|            |
                                           | 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                          1               |      1  1.0|
      Bacterium                            |                                                          4               |      1  4.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
      Inflammation, Acute                  |          2                                                               |      2  3.0|
      Inflammation, Chronic                |                                     1           1                        |      5  1.0|
      Inflammation, Chronic Active         |    1                                                                     |      1  1.0|
      Necrosis, Focal                      |                                                          1               |      1  1.0|
      Coronary Artery, Perivascular,       |                                                                          |            |
          Inflammation, Acute              |                                                                   2      |      1  2.0|
      Coronary Artery, Perivascular,       |                                                                          |            |
          Inflammation, Chronic Active     |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Capsule, Inflammation, Chronic Active|          3  2                                   2                        |      6  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                         1                                         1      |      2  1.0|
      Cyst                                 |       1                                                                  |      2  1.5|
      Hematopoietic Cell Proliferation     |          2                                                               |      3  1.3|
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                                              1                           |      1  1.0|
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  M  M  M  M  +  +  +  +  +  +  M  +  +  +  M  +  +|  31        |
      Cyst                                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  44        |
      Pars Distalis, Congestion            |       1                                                                  |      1  1.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |    2  3  2           3  1           2  1                          2      |     16  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                               1                                          |      1  1.0|
      Ultimobranchial Cyst                 |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |                                                    1                     |      1  1.0|
      Follicle, Cyst                       |                   2                                                      |      2  2.0|
      Follicular Cell, Hyperplasia         |                1           2  2              1                           |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3|            |
                                           | 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |    4  4  4  4     4                    3        4                 4  4   |     19  3.9|
      Cyst                                 |                2        2                                                |      7  2.5|
      Hemorrhage                           |                                                                      2   |      2  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Periovarian Tissue, Cyst             |                                     2        2                           |      4  2.5|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic                         | 1              1     2        1  2           1        1     4           2|     14  1.7|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
      Serosa, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |       +  +  +     +        +                                +            |   8        |
      Inflammation, Acute, Hemorrhagic     |                   2                                                      |      1  2.0|
      Inflammation, Acute                  |       4  4  4                                               2            |      6  3.0|
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |             3        4                                                   |      3  3.7|
      Hydrometra                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |    2  3  1        2                    1  2     4           2     2  4  3|     19  2.2|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
      Endometrium, Hyperplasia             | 4  2  3  2  3  3  2  3  3  1  2  2  3  3  3  2  3  3  3  2  2  2  2  4  3|     50  2.5|
      Muscularis, Congestion               |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                                          1               |      1  1.0|
      Myelofibrosis                        | 1  1  1     1  3  1  1  1  2  1  1  3  2  2  2     2  3     2  3  1  1  3|     42  1.8|
      Myeloid Cell, Hyperplasia            |                   3                                                      |      4  3.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lumbar, Bacterium                    |          4                                                               |      1  4.0|
      Lumbar, Hyperplasia, Plasma Cell     |          3           2        1                             3        3   |      9  2.7|
      Lumbar, Inflammation, Chronic Active |       3  4                                                               |      4  2.5|
      Mediastinal, Congestion              |    2                                                                     |      1  2.0|
      Mediastinal, Depletion Lymphoid      |    4                                                              3      |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3|            |
                                           | 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hemorrhage              |                                                                          |      2  1.5|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|    3                                                                     |      6  3.2|
      Mediastinal, Inflammation, Acute     |    3     3                                                        4      |      4  3.3|
      Pancreatic, Angiectasis              |                                                 2                        |      1  2.0|
      Pancreatic, Hemorrhage               |             4                                                            |      1  4.0|
      Pancreatic, Hyperplasia, Plasma Cell |                                                             2            |      2  2.0|
      Pancreatic, Inflammation, Acute      |                                                 3                        |      2  2.0|
      Renal, Bacterium                     |          4                                                               |      1  4.0|
      Renal, Hemorrhage                    |             4                                                            |      1  4.0|
      Renal, Hyperplasia, Plasma Cell      |    4     3  3        2                                               3   |     11  2.9|
      Renal, Inflammation, Chronic Active  |       3  4                                                               |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  +  +  +  M  +  +  +  +  +  M  +  M  +  +  M  M  +  +  M  M  +  M|  34        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                            2                                3            |      3  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +|  42        |
      Angiectasis                          |                            1                                             |      5  1.2|
      Congestion                           |                                                                          |      1  1.0|
      Depletion Lymphoid                   |                                                          2               |      2  2.5|
      Hemorrhage                           |                                                          1               |      2  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                       3     2           2|      4  2.3|
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.0|
      Inflammation, Acute                  |             4                                                            |      3  2.0|
      Inflammation, Chronic Active         |       1  3                                                               |      2  2.0|
      Serosa, Congestion                   |          1                                                               |      1  1.0|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
      Serosa, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                 1                        |      1  1.0|
      Depletion Lymphoid                   |                                                          1        3      |      4  2.5|
      Hematopoietic Cell Proliferation     |    4  3  3  3     2              3        3     3     2           4  2   |     23  2.9|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                            1  1              2     2  2        1         |      9  1.8|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Capsule, Abscess                     |                                                                          |      1  4.0|
      Capsule, Fibrosis                    |                                                                          |      1  4.0|
      Capsule, Inflammation, Acute         |    3     2                                                               |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3|            |
                                           | 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +|  37        |
      Depletion Lymphoid                   |    3  4  3  1                                                     3      |      9  2.9|
      Hemorrhage                           |                      1                                1                  |      3  1.0|
      Inflammation, Acute                  |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  +  M  M  M  M  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +|  31        |
      Galactocele                          |                                                                          |      1  2.0|
      Hyperplasia                          |    1                                                                     |      2  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                             1            |      3  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Necrotizing     |                                  3                                       |      2  3.5|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +        +                              |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                                          1               |      1  1.0|
      Hemorrhage                           |                                                          1               |      2  2.0|
      Infarct, Multifocal                  |                                                                          |      1  3.0|
      Thalamus, Mineralization             | 1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1     1  1|     40  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |   1        |
      Hemorrhage, Focal                    | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |          2                                                        1      |      2  1.5|
      Hemorrhage                           |                                                    1     3               |      6  1.3|
      Infiltration Cellular, Histiocyte    |                                        1                                 |      1  1.0|
      Inflammation, Chronic                |                      1                                                   |      1  1.0|
      Leukocytosis                         |             2                                                     2      |      3  2.7|
      Artery, Hyperplasia                  |                         1                                                |      1  1.0|
      Artery, Thrombosis                   |                                                                          |      1  1.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3|            |
                                           | 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Active                           |          3                                                               |      1  3.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                         2|      1  2.0|
      Perivascular, Inflammation, Acute    |       2  2                                                        2      |      4  2.5|
      Perivascular, Inflammation, Chronic  |                1                                                        2|      3  1.7|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                         2                                                |      1  2.0|
      Pleura, Inflammation, Acute          |             2                                                            |      2  2.5|
      Pleura, Inflammation, Chronic        |                                                                         2|      1  2.0|
      Pleura, Inflammation, Chronic Active,|                                                                          |            |
           Hemorrhagic                     |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Inflammation, Acute           |                         3                                                |      4  2.0|
      Mucosa, Glands, Inflammation, Acute  |          1     1     1        1     1           2           1  1     1  1|     18  1.1|
      Mucosa, Glands, Inflammation,        |                                                                          |            |
          Chronic Active                   |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                            3              1                              |      5  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                           +                              |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                            +                                             |   2        |
      Inflammation, Acute, Necrotizing     |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                          2               |      1  2.0|
      Bacterium                            |                                                          2               |      1  2.0|
      Glomerulosclerosis                   | 2  3  1  1  2                    2              3                    2   |     15  2.4|
      Inflammation, Chronic                | 2     2  2  1  2  1  1        2  1  1  1  1  1  1  1  1  1  1  1  1  1  2|     44  1.5|
      Inflammation, Chronic Active         |    2                                                                     |      1  2.0|
      Metaplasia, Osseous                  |                               1                                          |      2  1.0|
      Necrosis, Coagulative, Focal         |                                                          2               |      1  2.0|
      Capsule, Inflammation, Acute         |                                                                          |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Atrophy                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3|            |
                                           | 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Regeneration                    |                                     1  1              1                  |      7  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                | 1  1  1  1     1  1  1  1  2  1  1  1  1     1  1  1  1     1     1  1  2|     38  1.1|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Serosa, Inflammation, Acute          |             2                                                            |      2  1.5|
      Serosa, Inflammation, Chronic Active |    2                                                                     |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|             
                                           | 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.15                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +              M           +     +           +              +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +        +     M     +     +     +  +  +  +  +  M     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +              +           +     +           +              +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +              +           +                 +              +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +              +           +     +           +              +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +              +           +     M           +              +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +              +           +     +           +              +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +              +           +     +           +              +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +              +           +     +           +              +  +      |             
      Serosa, Inflammation, Acute          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +              +           +     +           +              +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                          1               |             
      Eosinophilic Focus                   |                                                             1            |             
      Fatty Change                         |       2                                2  2              1  1  2         |             
      Hematopoietic Cell Proliferation     |                            4                                   2  2      |             
      Hemorrhage                           |                                                          2  2           1|             
      Inflammation, Chronic                |                                                                2         |             
      Inflammation, Chronic Active         |                                              1     2                    1|             
      Mixed Cell Focus                     |                                                                      2   |             
      Necrosis, Coagulative                |                   2  1        1  1                 1  1  1        1  1   |             
      Pigmentation                         |                                                                      1  1|             
      Vacuolization Cytoplasmic, Diffuse   |                                                             1            |             
      Periportal, Inflammation, Chronic    |             2  1     2        1  1     1              1  1           1   |             
      Serosa, Inflammation, Acute          |                            4                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +                                                     +  +      |             
      Abscess                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                   4      |             
      Necrosis                             | 3                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +           +  +        +  +     +           +              +  +      |             
      Abscess                              |                            4                                      4      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Serosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +              +           +     +           +              +  +      |             
      Submandibular Gland, Atrophy         |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |                                                                1  1      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +              +           +     +           +              +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +              +           +     +           +              +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +              +           +     +           +              +  +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|             
                                           | 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.15                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +              +           +     +           +              +  +      |             
      Mineralization                       |                                     1                                    |             
      Epicardium, Inflammation, Acute      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +              +           +     +           +              +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +              +           +     +           +              +  +      |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +              +           +     +           +              +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +              +           +     +           +              +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +              M           M     M           M              M  +      |             
      Cyst                                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +           M  +           +     +           +        +     M  +      |             
      Pars Distalis, Angiectasis           |                                                          2               |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    2                          2                          2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +              M           +     +           +              +  +      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +                                                                        |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
      Abscess                              |                                                                   4      |             
      Angiectasis                          |                                                    3                     |             
      Cyst                                 |                1        2                                   1     3      |             
      Pigmentation                         |                                                          2               |             
      Periovarian Tissue, Cyst             |                      2                 3                                 |             
      Periovarian Tissue, Hemorrhage       |                                                                          |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Acute                           |                                                                          |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  |                                                                          |             
      Periovarian Tissue, Necrosis         | 3                                                                        |             
      Periovarian Tissue, Thrombosis       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                    4              4      |             
      Inflammation, Acute                  |                4           1                                             |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |                                                                          |             
      Endometrium, Hyperplasia             |    3  4  4  4     2  3  3     3  3     3  3  2  1  4  3  3  3  2  3  2  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|             
                                           | 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.15                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +              +           +     +           +              +  +      |             
      Congestion                           |                                                                          |             
      Myelofibrosis                        |                                                 1                        |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +  +     +  +  +     +           +  +  +        +  +     +|             
      Bronchial, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                   3      |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                    3                     |             
      Mediastinal, Abscess                 |                                                                   2      |             
      Mediastinal, Depletion Lymphoid      |                                     4                                    |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Inflammation, Acute     |                                                                          |             
      Pancreatic, Hemorrhage               |                                                       1                  |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                    3                     |             
      Renal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +              +           +     +           +              +  M     +|             
      Depletion Lymphoid                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +           +  M     +  +  +     +           +              +  +     +|             
      Abscess                              |                                                                          |             
      Angiectasis                          |                         2                                                |             
      Depletion Lymphoid                   |                                     2                                    |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Acute, Necrotizing     | 3                                                                        |             
      Inflammation, Chronic                |                                                                   3      |             
      Inflammation, Chronic Active         |                            3                                             |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +           +  +     +  +  +     +     +     +  +           +  +  +  +|             
      Angiectasis                          |                         1                                                |             
      Congestion                           |                         2                                                |             
      Depletion Lymphoid                   | 2                          4        3                                    |             
      Hematopoietic Cell Proliferation     |                            4  2                                2  3      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Capsule, Inflammation, Acute         |                                                                          |             
      Capsule, Inflammation, Chronic Active|                            1                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M              +           +     +           M              +  +      |             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   | 3                 2                 4                          2         |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             | 4                                                                 3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|             
                                           | 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.15                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M              M           M     +           +              +  M      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +              +           +     +           +              +  +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +              +           +     +           +              +  +      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                           +  +      |             
      Intercostal, Inflammation, Acute     |                                                                          |             
      Thoracic, Inflammation, Acute        |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +              +           +     +           +              +  +      |             
      Thalamus, Mineralization             |                                                 1                 1      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +        +  +        +     +           +        +     +  +  +  +|             
      Congestion                           | 2                                                                        |             
      Infiltration Cellular, Histiocyte    |                                                                2         |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
      Pleura, Inflammation, Acute          |                                                                          |             
      Pleura, Inflammation, Chronic Active |                                                                   4      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +              +           +                 +              +  +      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +              +           +     +           +              +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
      Hyperplasia                          |             1                                                            |             
      Inflammation, Chronic                |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                            2                                             |             
      Glomerulosclerosis                   |                            3                    4                        |             
      Inflammation, Chronic                |          1  2  1     1  1     2  1  1  1  1  2     2  2  2  1  2  2  1   |             
      Metaplasia, Osseous                  |                                                             2            |             
      Papilla, Inflammation, Acute,        |                                                                          |             
          Necrotizing                      |                            4                                             |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|             
                                           | 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.15                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Atrophy                         |                                                                         2|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Regeneration                    |          1                                                               |             
                                            __________________________________________________________________________|             
   Ureter                                  |    +                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +              +           +     +           +              +  +      |             
      Inflammation, Chronic                |                                                                1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5|            |
                                           | 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.15                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +                          +  +     +     M        +                 +|  14        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +     M     +     +     +  +  +  +  +     M        M  +     +  +     +|  28        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +                       +  +  +     +     +        +                 +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A                       +     M                    M                 M|   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                          +  +     +     +        +                 +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +                          M  +     M     M        +                 +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +                          +  +     +     +        A                 +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +                          +  +     +     +        A                 +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +                          +  +     +     +        M                 +|  15        |
      Serosa, Inflammation, Acute          | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +                          +  +     +     +        M                 +|  15        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration                         |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      1  1.0|
      Fatty Change                         |                                                                          |      6  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.7|
      Hemorrhage                           |                      1  1                                            2   |      6  1.5|
      Inflammation, Chronic                | 2     2  2  1  1  1                                                      |      7  1.6|
      Inflammation, Chronic Active         |    2                                      1                    1  1      |      7  1.3|
      Mixed Cell Focus                     |                      2                                               2   |      3  2.0|
      Necrosis, Coagulative                |                         1                 1        1     1     1         |     14  1.1|
      Pigmentation                         |                                                                          |      2  1.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                 2                        |      2  1.5|
      Periportal, Inflammation, Chronic    |          2              1           1              1     1           2  1|     16  1.3|
      Serosa, Inflammation, Acute          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +                             +                                      +|   8        |
      Abscess                              |                                                                         4|      1  4.0|
      Inflammation, Acute                  | 1  1                             3                                       |      3  1.7|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +                       M  +  +     +     M        +  +           +  +|  19        |
      Abscess                              |                                                                          |      2  4.0|
      Inflammation, Acute                  |                                                                         2|      1  2.0|
      Inflammation, Chronic                |                                                       1              1   |      2  1.0|
      Serosa, Inflammation, Acute          | 3  1                             3                                       |      3  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                          +  +     +     M        +              +  +|  16        |
      Submandibular Gland, Atrophy         |                                                                      1   |      1  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         |                               1                                      1   |      4  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5|            |
                                           | 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.15                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +                          +  +     +     +        +                 +|  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +                          +  +     +     +        +                 +|  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +                          +  +     +     +        +                 +|  16        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +                    +  +     +     M        +                 +|  16        |
      Mineralization                       |                                                                          |      1  1.0|
      Epicardium, Inflammation, Acute      |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +                          +  +     +     M        +                 +|  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +                          +  +     +     M        +                 +|  15        |
      Congestion                           |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +                          +  +     +     M        +                 +|  15        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +                          +  +     +     M        +                 +|  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +                          +  +     M     M        +                 +|   8        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M                       +  +  +     +     M     +  +           +  +  +|  17        |
      Pars Distalis, Angiectasis           |                            3                       2              2      |      4  2.3|
      Pars Distalis, Cyst                  |                                                                      1   |      1  1.0|
      Pars Distalis, Hyperplasia           |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +                          +  +     +     M        +                 +|  14        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                      +   |   2        |
      Cyst                                 |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Abscess                              | 4                                4                                      4|      4  4.0|
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |       2           2     2                                2     1         |      9  1.8|
      Pigmentation                         |          2     2  2  2     1                                             |      6  1.8|
      Periovarian Tissue, Cyst             |             3        3                                      1            |      5  2.4|
      Periovarian Tissue, Hemorrhage       |                                                 4                        |      1  4.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Acute                           |    2                                                                     |      1  2.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5|            |
                                           | 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.15                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
           Chronic Active                  |                                                                         4|      1  4.0|
      Periovarian Tissue, Necrosis         |                                                                          |      1  3.0|
      Periovarian Tissue, Thrombosis       |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |    4                                                                    4|      4  4.0|
      Inflammation, Acute                  | 2                       1                                      1         |      5  1.8|
      Necrosis, Coagulative                |                            4                                             |      1  4.0|
      Pigmentation                         |                                                          2               |      1  2.0|
      Endometrium, Hyperplasia             | 3        4  3  4  3  3  3  4  1  1  3  2  3     3  3  2  2  4  3  1  3   |     42  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  M                          +  +     +     +        +                 +|  15        |
      Congestion                           |                                              4                           |      1  4.0|
      Myelofibrosis                        |                                                                          |      1  1.0|
      Myeloid Cell, Hyperplasia            |                                  3                                      4|      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M                 +     +  +  +     +     +  +     M  +              +|  24        |
      Bronchial, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Lumbar, Hemorrhage                   |                            4                                             |      1  4.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                                         3|      1  3.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Mediastinal, Abscess                 |                                                                          |      1  2.0|
      Mediastinal, Depletion Lymphoid      |                                                                          |      1  4.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                         4|      1  4.0|
      Mediastinal, Inflammation, Acute     |                                  2                                      4|      2  3.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  1.0|
      Renal, Hyperplasia, Lymphoid         |                                                                         3|      1  3.0|
      Renal, Hyperplasia, Plasma Cell      | 2                                3                                       |      3  2.7|
      Renal, Inflammation, Acute           |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M                          +  +     +     M        M                 +|  12        |
      Depletion Lymphoid                   |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M                          +  +     +     +  +     M                 +|  18        |
      Abscess                              | 4                                                                        |      1  4.0|
      Angiectasis                          |                                                                          |      1  2.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                         4|      1  4.0|
      Inflammation, Acute                  |                                  4                                       |      1  4.0|
      Inflammation, Acute, Necrotizing     |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5|            |
                                           | 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.15                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Necrosis                             |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +              +  +     +     +        +  +           +  +|  29        |
      Angiectasis                          |                                                                          |      1  1.0|
      Congestion                           |                                                                          |      1  2.0|
      Depletion Lymphoid                   |                               1  1           3                           |      6  2.3|
      Hematopoietic Cell Proliferation     | 2  2                             4                                      3|      8  2.8|
      Hyperplasia, Lymphoid                |                                                                      3   |      1  3.0|
      Capsule, Inflammation, Acute         |    3                                                                     |      1  3.0|
      Capsule, Inflammation, Chronic Active|                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +                          +  +     +     M        +                 M|  11        |
      Cyst                                 |                               1                                          |      1  1.0|
      Depletion Lymphoid                   |    3                          3  3                                       |      7  2.9|
      Hemorrhage                           |    1                                                                     |      1  1.0|
      Necrosis                             |                                  4                                       |      3  3.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M                          +  M     M     M        M                 M|   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                          +  +     +     +        +                 +|  16        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                          +  +     +     +        +                 +|  16        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   4        |
      Intercostal, Inflammation, Acute     |                                  1                                       |      1  1.0|
      Thoracic, Inflammation, Acute        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                          +  +     +     +        +                 +|  16        |
      Thalamus, Mineralization             | 1                                                                       1|      4  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +        +                 +  +     +     M        +                 +|  21        |
      Congestion                           |    4                                                                     |      2  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Perivascular, Inflammation, Chronic  |                                        2              2                  |      2  2.0|
      Pleura, Inflammation, Acute          |    4                                                                     |      1  4.0|
      Pleura, Inflammation, Chronic Active |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                             +                    +                 +|  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5|            |
                                           | 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.15                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           | 1                                                                        |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |    2                             2                                       |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +                          +  +     +     M        +                 +|  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                                                          |      1  2.0|
      Glomerulosclerosis                   |                                                                          |      2  3.5|
      Inflammation, Chronic                |    1  2  2  2  1  1  1  2  1     1  1  1  1     1  2  1     1  2  1  1  1|     39  1.4|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Papilla, Inflammation, Acute,        |                                                                          |            |
          Necrotizing                      |                                                                          |      1  4.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Atrophy                         |                         2                                                |      2  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Regeneration                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +                          +  +     +     +        +                 +|  16        |
      Inflammation, Chronic                |                                  1     1              1                 1|      6  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|             
                                           | 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.3 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Acute                  |             3                                                            |             
      Necrosis                             |             3                                                            |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation, Acute                  |                         2  1                                             |             
      Inflammation, Chronic                |                      1                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  A  M  +     +  +  +  +  +  +  +           +  +|             
      Mesothelium, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Acute                  |                                                       3                  |             
      Epithelium, Hyperplasia              |                                                                          |             
      Mesothelium, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  A  M  +  M  +  +  +  +  +  +  +  A  M  M  +  +|             
      Mesothelium, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +|             
      Mesothelium, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  A  A  +  +  +|             
      Mesothelium, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +|             
      Hemorrhage                           |                               2                                          |             
      Mesothelium, Hyperplasia             |                                                                          |             
      Serosa, Inflammation, Chronic Active |                         2                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                          1               |             
      Clear Cell Focus                     |                                        1                                 |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                      1  2  1                                             |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                  1                                      2|             
      Necrosis, Coagulative                |          1     1     1        2              1  1                    1   |             
      Periportal, Inflammation, Chronic    | 1  2     2     1  1                    1     2     1  1              1   |             
      Serosa, Inflammation, Acute          |                         3  1                          3                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Fibrosis                             |                         2                                                |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                         4                                                |             
      Necrosis                             |                         3                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Atrophy                              |       2                                                                  |             
      Inflammation, Chronic                | 1     2           1  1           1     1     1                           |             
      Duct, Dilatation                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|             
                                           | 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.3 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Serosa, Inflammation, Acute          |                                                       3                  |             
      Serosa, Inflammation, Chronic Active |                         4  2                                             |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |          1     1                                                         |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |          1     1  2  1  1        1     1  1  1     1                 1  1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                      2   |             
      Hyperkeratosis                       |                                                                      2   |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |                                                                      3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  1  1  1                                                               |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +     +  +  +  +  +     +     +  +  +     +                 +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                         1                 1           1                  |             
      Mineralization                       |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Inflammation, Chronic Active|                         2                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           1                              |             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                         2                                                |             
      Inflammation, Chronic Active         |                         2                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  M  +  +  +  M  +  M  +  M  +  M  M  +  +  M  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    1  1  1     2  1     2              1           1                 1  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|             
                                           | 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.3 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                         4  4                 4  4     4                  |             
      Angiectasis                          |                            2                                             |             
      Cyst                                 |    2           1     3  2  X           3     3                       2  2|             
      Necrosis, Coagulative                |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                   2  2                 2                                 |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Abscess                              |                4                                                         |             
      Hydrometra                           |                                                                          |             
      Inflammation, Acute                  |                      1  2           1        2        3                  |             
      Inflammation, Chronic Active         |          1                                               2               |             
      Endometrium, Hyperplasia             | 2  3  2  3     3  3  3  2        3  1  3  2  2     1  3  2           3  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             2                                               4  4  4      |             
      Hypoplasia                           |                                                             4  2  3      |             
      Myelofibrosis                        | 2  1  1  1     1     2           3     1  2        1                 1  2|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Hyperplasia, Plasma Cell     |                         3                                                |             
      Lumbar, Inflammation, Acute          |                                                                          |             
      Mediastinal, Abscess                 |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                       2                  |             
      Mediastinal, Inflammation, Acute     |                            3                          1                  |             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Pancreatic, Hyperplasia, Plasma Cell |                            2                                             |             
      Renal, Hyperplasia, Plasma Cell      |                2        2                             3              3   |             
      Renal, Inflammation, Acute           |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  +  M  +  +  M  +  M  +  +  M  +  M  +  +  +  +  +  +  M|             
      Depletion Lymphoid                   |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|             
                                           | 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.3 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                         3                                                |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |                            3                                   3  3      |             
      Hematopoietic Cell Proliferation     |    1                    4  3           1     2                           |             
      Hyperplasia, Lymphoid                |                   1                       2                              |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  M  +  +  +  +  +  M  +  M  +  +  M  +  +  +  M  M  +  +  +  +|             
      Depletion Lymphoid                   |                            3                          3        4  4      |             
      Hemorrhage                           |                                                 1                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  M  +  +  +  M  +  M  M  M  +  M  M  M  M  M  +  M  M  M  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
      Thoracic, Inflammation, Acute        |                                                       2                  |             
      Thoracic, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             2            |             
      Cerebellum, Inflammation, Chronic    |                                                                          |             
      Thalamus, Mineralization             | 1  1  1  1        1     1     1              1     1                 1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                       2                  |             
      Congestion                           |                            1                                             |             
      Hemorrhage                           |                2              2                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|             
                                           | 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.3 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                      1                                1                  |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Perivascular, Inflammation, Acute    |                                                       3                  |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                 2                        |             
      Pleura, Inflammation, Acute          |                                                                          |             
      Pleura, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +           +  +|             
      Lumen, Inflammation, Acute           |                                        2     2                           |             
      Mucosa, Glands, Dilatation           |                                                                      1   |             
      Mucosa, Glands, Inflammation, Acute  | 1  1  1        1                          1        1                 1   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                 2     2                 2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                          +               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
      Hyperplasia                          |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Glomerulosclerosis                   |                         3                                                |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Inflammation, Chronic                | 1  1  1  1     1  2  1  1  1     1  1  2  1  1  2  1  2  1           1  2|             
      Metaplasia, Osseous                  |    1                       1                                             |             
      Artery, Thrombosis                   |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Regeneration                    |          1                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                | 2  1  1  1     1  1  1  1        1     1  1  1  1  1  1              1  1|             
      Inflammation, Chronic Active         |                                                                          |             
      Submucosa, Fibrosis                  |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9|            |
                                           | 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.3 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|  47        |
      Inflammation, Acute                  |                   3                                                      |      3  2.0|
      Inflammation, Chronic                |       1  1  1                    1        1  1                           |      7  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|  40        |
      Mesothelium, Hyperplasia             |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              | 2                                                                        |      1  2.0|
      Mesothelium, Hyperplasia             |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Mesothelium, Hyperplasia             |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Mesothelium, Hyperplasia             |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|  44        |
      Mesothelium, Hyperplasia             |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|  45        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Mesothelium, Hyperplasia             |                   1                                                      |      1  1.0|
      Serosa, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      1  1.0|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Congestion                           |                                     2                                    |      1  2.0|
      Hematopoietic Cell Proliferation     |                3  3                 3                          2         |      7  2.1|
      Hemorrhage                           |                               2                                          |      1  2.0|
      Inflammation, Chronic                |                                                    1                     |      3  1.3|
      Necrosis, Coagulative                | 1              2        1  1                    1                        |     12  1.2|
      Periportal, Inflammation, Chronic    | 1     1  1  1        1  1  1              1  1        1  2               |     21  1.2|
      Serosa, Inflammation, Acute          |                   3                                                      |      4  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                 +                                   +|   4        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Acute                  |                   3                                                      |      1  3.0|
      Inflammation, Chronic Active         |                                     3                                    |      2  3.5|
      Necrosis                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9|            |
                                           | 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.3 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                   4                                                      |      1  4.0|
      Atrophy                              |                   3                                                      |      2  2.5|
      Inflammation, Chronic                | 2        1  1              1  1  1        1  1  1  1  1     1        1   |     20  1.1|
      Duct, Dilatation                     |                                              3                           |      1  3.0|
      Serosa, Inflammation, Acute          |                                                                          |      1  3.0|
      Serosa, Inflammation, Chronic Active |                                     2                                    |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                   +      |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic                          |             1                                                            |      3  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         | 1  1  1  1  1        1     1  2  1  1     1  1     1     1  1            |     27  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Acanthosis                           |       1                          2                                      1|      4  1.5|
      Hyperkeratosis                       |       1                          1                                      2|      4  1.5|
      Hyperplasia, Basal Cell              |                                                                         1|      1  1.0|
      Inflammation, Chronic Active         |                                  2                                       |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Necrotizing                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Inflammation, Chronic                |          1  1     1  1  1  1     1                    1     1            |     13  1.1|
      Inflammation, Chronic Active         |    1  1        2                                                         |      3  1.3|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +     +     +     +              +  +     +  +        +        +   |  28        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                                                4         |      1  4.0|
      Inflammation, Acute                  |                   1                                                      |      1  1.0|
      Inflammation, Chronic                |          1     2                                            1            |      6  1.2|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Inflammation, Chronic Active|                2                                               2         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  1.0|
      Cyst                                 |                                                                      2   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9|            |
                                           | 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.3 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  M  +  +  M|  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  47        |
      Pars Distalis, Angiectasis           |       2                                1                                 |      2  1.5|
      Pars Distalis, Cyst                  |                                                             1            |      1  1.0|
      Pars Distalis, Hyperplasia           | 2  1     2  2           2        2     3  2  1  2  2        1            |     22  1.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 1     1                                               1                  |      3  1.0|
      Ultimobranchial Cyst                 |                   2                                                      |      1  2.0|
      Follicle, Cyst                       | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
      Abscess                              |                4  4     3           4                          4         |     10  3.9|
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |       2  4  3     4     2     4        2                                 |     16  2.6|
      Necrosis, Coagulative                |                               3                                          |      1  3.0|
      Periovarian Tissue, Cyst             |                                  4              2                        |      2  3.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic                         |                                           2        1                     |      5  1.8|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic Active                  |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Abscess                              |                                                                         1|      2  2.5|
      Hydrometra                           |                                                                3         |      1  3.0|
      Inflammation, Acute                  |                   2                    2  2                             2|      9  1.9|
      Inflammation, Chronic Active         |                2                                   1                     |      4  1.5|
      Endometrium, Hyperplasia             | 2  3  2  2  2  3  2  2  2  3  3  3  2  3  2  2  1  3  3  2  2  2     2   |     41  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      4  3.5|
      Hypoplasia                           |                                                                          |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9|            |
                                           | 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.3 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Myelofibrosis                        | 1  1  2  1  1           1  1  2  1     2  1  2  1     1  1           1   |     28  1.4|
      Myeloid Cell, Hyperplasia            |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lumbar, Hyperplasia, Plasma Cell     |                4                                                         |      2  3.5|
      Lumbar, Inflammation, Acute          |                                                                2         |      1  2.0|
      Mediastinal, Abscess                 |                                                                2         |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                2                                                         |      2  2.0|
      Mediastinal, Inflammation, Acute     |                                                                          |      2  2.0|
      Mediastinal, Inflammation, Chronic   |                                                                          |            |
          Active                           |                   2                                                      |      1  2.0|
      Pancreatic, Hyperplasia, Plasma Cell |                   3                                                      |      2  2.5|
      Renal, Hyperplasia, Plasma Cell      |                4  4                 3                                    |      7  3.0|
      Renal, Inflammation, Acute           |                                     2                          2         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  M  M  +  +  +  M  M  +  M  M  +  +  +  M  +  +  +  +  +  +  +|  30        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Ectasia                              |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  41        |
      Angiectasis                          |                                              1                           |      1  1.0|
      Hyperplasia, Lymphoid                |                                  2                 1                     |      2  1.5|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                3                                                         |      1  3.0|
      Depletion Lymphoid                   |                2  3                 3                                   3|      7  2.9|
      Hematopoietic Cell Proliferation     |                   3                 4                       3            |      8  2.6|
      Hyperplasia, Lymphoid                |                         1  1     3        1        1                 1   |      8  1.4|
      Inflammation, Acute                  |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|  39        |
      Depletion Lymphoid                   |                   3                                            4         |      6  3.5|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |    2                       2                                             |      2  2.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  M  M  M  +  M  +  M  M  M  M  +  +  +  M  +  +  M  M  +  M|  23        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Acute, Necrotizing     |                                                                         4|      1  4.0|
      Subcutaneous Tissue, Fibrosis        |                               1                       2                  |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9|            |
                                           | 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.3 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                          +  +      |   4        |
      Thoracic, Inflammation, Acute        |                                     3                                    |      2  2.5|
      Thoracic, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                1         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Cerebellum, Inflammation, Chronic    |       1                                                                  |      1  1.0|
      Thalamus, Mineralization             | 1  1        1     1  1  1     1  1     1           1  1  1  1        1   |     25  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                                                4         |      2  3.0|
      Congestion                           |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                   2      |      3  2.0|
      Inflammation, Chronic                |                                     2                                    |      1  2.0|
      Inflammation, Chronic Active         |                   2     1                                                |      2  1.5|
      Leukocytosis                         |                3                                                         |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic                          |                                                    2                     |      1  2.0|
      Perivascular, Inflammation, Acute    |                                                                          |      1  3.0|
      Perivascular, Inflammation, Chronic  |          1                                      1  2                     |      3  1.3|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Pleura, Inflammation, Acute          |                   4                                                      |      1  4.0|
      Pleura, Inflammation, Chronic        |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  M  +  +  +|  41        |
      Lumen, Inflammation, Acute           |                                                                          |      2  2.0|
      Mucosa, Glands, Dilatation           |                                                                          |      1  1.0|
      Mucosa, Glands, Inflammation, Acute  | 1  1     1  1     1     1  1              1     1  1  1     1            |     19  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                         2|      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9|            |
                                           | 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.3 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                                                4         |      1  4.0|
      Glomerulosclerosis                   |                   3                                                      |      2  3.0|
      Hydronephrosis                       |                                                                         2|      1  2.0|
      Inflammation, Acute, Necrotizing     |                                                                3         |      1  3.0|
      Inflammation, Chronic                | 2  1  2  1  2  2  2  1  1  1  2  1  2  1  2  2  1  1  2  2           2   |     41  1.4|
      Metaplasia, Osseous                  |                                                                          |      2  1.0|
      Artery, Thrombosis                   |                                                                         X|      1     |
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Regeneration                    | 1  1     1              1  1                 1  1           1            |      9  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Acute                  |                                                          1               |      1  1.0|
      Inflammation, Chronic                | 1  1  1  1  1     1  1  1  2  1  1  2  1  1  1     1  1        2     1   |     36  1.1|
      Inflammation, Chronic Active         |                                                 2                        |      1  2.0|
      Submucosa, Fibrosis                  |                                                                2         |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                2         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|             
                                           | 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
      Inflammation, Chronic                | 1  1                          1                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   2        2                    2                 2      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   2                                   2                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Fatty Change                         | 1  2  1     1     1                                               2      |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                        4                                 |             
      Infarct                              |                                                                4         |             
      Inflammation, Chronic                |       1                                   1        1                    1|             
      Inflammation, Chronic Active         |                   1                                                      |             
      Mineralization                       |                                                                2         |             
      Necrosis, Coagulative                |       1                             4                                    |             
      Pigmentation                         |                         2                                                |             
      Periportal, Inflammation, Chronic    |          1           1     1     1                             2     2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Fibrosis                             |                                                 1                        |             
      Inflammation, Chronic                |                                                 1                        |             
      Mineralization                       |                                                 1                        |             
      Necrosis, Coagulative                |                                                                          |             
      Artery, Thrombosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectopic Tissue                       |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 1        1  1     1        1  1           1        1     1  1     1      |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Artery, Mineralization               |                                                 1     1                  |             
      Duct, Dilatation                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|             
                                           | 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Inflammation, Chronic |                                              1                           |             
      Parotid Gland, Mineralization        |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         | 1  1  1  1  1     2  1  2  1  1  2        2  1  1        2  1  1  1     1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                         2|             
      Hyperkeratosis                       |                                                                         2|             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation, Acute                  |                               2                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Karyomegaly, Chronic Active          |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                               2                                          |             
      Inflammation, Chronic                |       1           1              1                    1        1         |             
      Inflammation, Chronic Active         |                      1                                            1      |             
                                            __________________________________________________________________________|             
   Tooth                                   | +     +  +        +  +     +  +  +              +     +                  |             
      Incisor, Abscess                     |       3              4                                                   |             
      Incisor, Dysplasia                   | 3     2  1        1  2           3                    1                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1                             1                 1        1            |             
      Coronary Artery, Mineralization      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Inflammation, Chronic       |          2                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  1                                       |             
      Hyperplasia                          |                                           1           2     2     1      |             
      Pigmentation                         |                                                                         1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  M  M  +  +  +  M  M  M  +  M  +  +  +  M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                           1                              |             
      Pars Distalis, Hyperplasia           |          1                    1                                         1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|             
                                           | 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 2                        |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                            1                                             |             
      Follicle, Cyst                       |             2                                                            |             
      Follicular Cell, Hyperplasia, Focal  |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +  +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1  1  1           2        1              1  1              1         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +                       +                                +            |             
      Abscess                              | 4  2                                                        4            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                            1                                             |             
      Duct, Dilatation                     |    3                                                                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Inflammation, Chronic                | 1  1  2  2  1     1  1     1  1  1        1  1  1  1  1  1     1  1     1|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |       1  1  1     1  1     1  1  1                       1     1        1|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             3                                                            |             
      Inflammation, Chronic                |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                                                      1   |             
      Seminiferous Tubule, Mineralization  |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Angiectasis                |                                                                          |             
      Inguinal, Ectasia                    |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Lumbar, Pigmentation                 |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  M  +  +  +  +  M  +  M  M  M  +  +  +  +  M  M  M  +  M  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|             
                                           | 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Plasma Cell             |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Angiectasis                          |          2        2     2  2  2        3  2  2  2  1  2  3     3  2      |             
      Depletion Lymphoid                   |             3                                                            |             
      Ectasia                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |             4                       2                                    |             
      Hyperplasia, Lymphoid                |          3                    4                                          |             
      Inflammation, Acute                  |                         3           3                                    |             
      Thrombosis                           |    2                                                           2         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                   2     4                                      2         |             
      Hyperplasia, Lymphoid                |          3                                                               |             
      Necrosis, Coagulative                |                                                                          |             
      Artery, Endothelium, Hyperplasia     |                                                          1               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  A  +  M  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    1     1                    1              1           2        X     1|             
      Depletion Lymphoid                   |                                                             2            |             
      Hemorrhage                           |                                              1                           |             
      Necrosis                             |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |             2                                                            |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Inflammation, Chronic                |                                                    3                     |             
      Inflammation, Chronic Active         |    1                    4                                                |             
      Subcutaneous Tissue, Abscess         |                         4                                                |             
      Subcutaneous Tissue, Fibrosis        |                                                    2        2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          |       3           4  4        4  4     3  4  4  4  4  4  4           4  4|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Abdominal, Regeneration              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             | 1  1  1  1  1  1  1  1     1  1  1     1  1  1  1     1  1  1  1        1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|             
                                           | 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   1                                1                     |             
      Infiltration Cellular, Histiocyte    |                                                    2        1            |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       1                                                                  |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |             2                                                            |             
      Peribronchial, Inflammation, Chronic |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                              1                           |             
      Pleura, Inflammation, Acute          |             1                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Inflammation, Acute           | 2                                                                        |             
      Mucosa, Inflammation, Acute          | 2  1              1  1           1     1  1  1  1     2           1      |             
      Mucosa, Inflammation, Chronic Active |                                                    2                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                      1                                                   |             
      Nasolacrimal Duct, Metaplasia,       |                                                                          |             
          Squamous                         |                                                                          |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          I                                                               |             
      Cornea, Inflammation, Chronic Active,|                                                                          |             
           Necrotizing                     |                                                                          |             
      Lids, Inflammation, Chronic Active,  |                                                                          |             
           Necrotizing                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
      Inflammation, Chronic                |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Bacterium                            |                                                                          |             
      Cyst                                 |                               1                                          |             
      Glomerulosclerosis                   | 1                                                              1         |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic                | 1  2  1  1        1  2  2  1  1  2  1  1  1  1  1  2  1  1  2  2  1  1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|             
                                           | 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Papilla, Necrosis, Coagulative       |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Atrophy                         |                      2                                                   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Mineralization                  |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Regeneration                    | 1  1  1           2  2  2  1  1  1     2  1  1     1  1  2  2  2        1|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Vacuolization Cytoplasmic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                        X                                 |             
      Calculus Micro Observation Only      |                                        X                                 |             
      Inflammation, Chronic                |    1  1  1  1  1  1  1  1        1        1  1  1  1  1     1  1     1  1|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3|            |
                                           | 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Chronic                |          1              1                                                |      5  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                      3                                                   |      5  2.2|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                        4                                1|      4  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                1         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 2                                                                        |      1  2.0|
      Basophilic Focus                     |                                                 2                        |      1  2.0|
      Fatty Change                         |                1  2                 1                          1        1|     11  1.3|
      Fibrosis                             |                                     1                                    |      1  1.0|
      Hematopoietic Cell Proliferation     |       1                                                                  |      1  1.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                     1        1  1              1         |      8  1.0|
      Inflammation, Chronic Active         | 1                                                                        |      2  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis, Coagulative                | 1           3                                                            |      4  2.3|
      Pigmentation                         |                                                                          |      1  2.0|
      Periportal, Inflammation, Chronic    |          1     1  1     1  1  1  1     2  1                       1      |     16  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                 +        +         |   4        |
      Fibrosis                             |                                     2                 2        1         |      4  1.5|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Mineralization                       |                                     1                 1                  |      3  1.0|
      Necrosis, Coagulative                |                                     4                 4        1         |      3  3.0|
      Artery, Thrombosis                   |                                                       X                  |      1     |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                    1                     |      1  1.0|
      Ectopic Tissue                       |                                                                   2      |      1  2.0|
      Hyperplasia                          |                                                          2               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3|            |
                                           | 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |          1                             1  1     1           1  1         |     17  1.0|
      Necrosis, Coagulative                |                            1                                             |      1  1.0|
      Vacuolization Cytoplasmic            |                                     2                                    |      1  2.0|
      Artery, Mineralization               |                         1  2                                1            |      5  1.2|
      Duct, Dilatation                     |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parotid Gland, Inflammation, Chronic |                                                                          |      1  1.0|
      Parotid Gland, Mineralization        |                                        1     1                           |      2  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         | 1  1  1  2  1  1  1  1  2  2  2  2     1  1  1  1  1     1  1  1  1  1  2|     42  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acanthosis                           |          1        1                                   2                  |      4  1.5|
      Hyperkeratosis                       |          1        1                                   2           2      |      5  1.6|
      Hyperplasia, Basal Cell              |          1        1        2                                      2      |      4  1.5|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                       2                  |      1  2.0|
      Inflammation, Chronic Active         | 2                                         1                       1      |      3  1.3|
      Karyomegaly, Chronic Active          | 2                                                                        |      1  2.0|
      Ulcer                                | 2                                                                        |      1  2.0|
      Epithelium, Mineralization           |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                      1     1                                             |      2  1.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                | 1              1  1                 1  1                    1  1         |     12  1.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +                 +                       +           +         |  17        |
      Incisor, Abscess                     | 3  4  2                    4                       3           2         |      8  3.1|
      Incisor, Dysplasia                   |                            3                       3                     |      9  2.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    1                       1  1  1  1           1                        |     10  1.0|
      Coronary Artery, Mineralization      |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Inflammation, Chronic       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3|            |
                                           | 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      1  1.0|
      Hyperplasia                          |                               2                                          |      5  1.6|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  M  +  M  +  M  M  M  +  M  M  +  +  +  M  M  M  +  M  +  +  M|  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Cyst                  |                   2                    1     X        X  1              1|      7  1.2|
      Pars Distalis, Hyperplasia           |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                  1                                       |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                   +      |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |    1                    1     1  1     1     1  1  1        1  1  1  1   |     20  1.1|
      Inflammation, Chronic Active         |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +                 +     +     +                 +  +      |  10        |
      Abscess                              |                                  4           4                    4      |      6  3.7|
      Inflammation, Chronic                |                1                                               1         |      2  1.0|
      Inflammation, Chronic Active         |                                        4                                 |      2  2.5|
      Duct, Dilatation                     |                3                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Necrotizing     |                                                          4               |      1  4.0|
      Inflammation, Chronic                |    1  1  1     1  1  1  1  2  1     1  1  1     1  1        1     1  1   |     36  1.1|
      Epithelium, Hyperplasia              |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                              1                           |      1  1.0|
      Inflammation, Chronic                |          1     1  1  1     1  1  1        1  1     1  2                  |     22  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3|            |
                                           | 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                          4               |      1  4.0|
      Seminiferous Tubule, Atrophy         |                                                          4               |      2  2.5|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myeloid Cell, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Angiectasis                |                                                          2               |      1  2.0|
      Inguinal, Ectasia                    |                                           2                              |      1  2.0|
      Lumbar, Hyperplasia, Lymphoid        |                                           2                 3            |      2  2.5|
      Lumbar, Hyperplasia, Plasma Cell     |                                                          3               |      1  3.0|
      Lumbar, Pigmentation                 |                                  2                                       |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |          2                                2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  +  +  +  M  +  M  +  +  M  M  M  M  +  M  M  M  M  +  +  +  +  +|  27        |
      Depletion Lymphoid                   |                                              2                           |      1  2.0|
      Hyperplasia, Plasma Cell             |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|  45        |
      Angiectasis                          | 2  1  3        1     2  2     1        1  1  2  2           2  2  2      |     28  1.9|
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Ectasia                              |                                        3           3                     |      2  3.0|
      Hematopoietic Cell Proliferation     |       2                                                                  |      1  2.0|
      Hemorrhage                           |                                                          2               |      3  2.7|
      Hyperplasia, Lymphoid                |          1                                                               |      3  2.7|
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Thrombosis                           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |                                                          2               |      1  2.0|
      Hematopoietic Cell Proliferation     | 2     3                    3                             2               |      7  2.6|
      Hyperplasia, Lymphoid                |    2     2                                                  2            |      4  2.3|
      Necrosis, Coagulative                |             2                                                            |      1  2.0|
      Artery, Endothelium, Hyperplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +|  41        |
      Cyst                                 |          1                          1     1                 1        1   |     12  1.1|
      Depletion Lymphoid                   |                            3           2           3                     |      4  2.5|
      Hemorrhage                           |                                                 1              1        1|      4  1.0|
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3|            |
                                           | 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                   1      |      2  1.5|
      Inflammation, Acute, Necrotizing     |                                                       2  4               |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Subcutaneous Tissue, Abscess         |                                                                          |      1  4.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Joint, Tarsal, Hyperostosis          | 4  4     4  4        4  4     4  3     4  4  4  4  4  X  4  4  4  4  4   |     33  3.9|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   2        |
      Abdominal, Regeneration              |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thalamus, Mineralization             | 1  1     1     1        1  1  1  1  1  1  1  1  1     1  1  1  1  1  1   |     39  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                               1     1  1                                 |      5  1.0|
      Infiltration Cellular, Histiocyte    |                               1                                          |      3  1.3|
      Inflammation, Chronic Active         |                                  2                                       |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                           1  1                           |      3  1.0|
      Bronchiole, Epithelium, Hyperplasia  |       1                                                                  |      1  1.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Peribronchial, Inflammation, Chronic |          1                                                               |      1  1.0|
      Perivascular, Inflammation, Chronic  |                                                                      2   |      2  1.5|
      Pleura, Inflammation, Acute          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Inflammation, Acute           |                                  1                                       |      2  1.5|
      Mucosa, Inflammation, Acute          | 2              1  1  1  1     1  1     1  1  1  1  1           1  1  1   |     26  1.1|
      Mucosa, Inflammation, Chronic Active |    1                                                                     |      2  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                    4                     |      1  4.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3|            |
                                           | 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Metaplasia,       |                                                                          |            |
          Squamous                         |                                                       2                  |      1  2.0|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Chronic Active                  |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |       +                                                                  |   1        |
      Inflammation, Chronic Active         |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                                     +            |   2        |
      Cornea, Inflammation, Chronic Active,|                                                                          |            |
           Necrotizing                     |                                                             4            |      1  4.0|
      Lids, Inflammation, Chronic Active,  |                                                                          |            |
           Necrotizing                     |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                                                     +            |   3        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                                                          4               |      1  4.0|
      Bacterium                            |                                                          3               |      1  3.0|
      Cyst                                 |                                                                          |      1  1.0|
      Glomerulosclerosis                   |                1                                      2                  |      4  1.3|
      Hydronephrosis                       |                                                          3               |      1  3.0|
      Inflammation, Chronic                | 1  2  1  3     1  1  2  2  2  1  1  1  1  1  1  1           1  1  1  1  1|     44  1.3|
      Metaplasia, Osseous                  |                            1                                      1      |      2  1.0|
      Papilla, Necrosis, Coagulative       |                                                          3               |      1  3.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Atrophy                         |                1                                                         |      2  1.5|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Mineralization                  |                1                                                         |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Regeneration                    | 2  1           1  1  1  1     1  1     1  1  1  1  1        1  1  1  1  1|     36  1.2|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Vacuolization Cytoplasmic       |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                               +                 +                    +  +|   4        |
      Calculus Micro Observation Only      |                               X                 X                    X  X|      4     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Gross Observation           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3|            |
                                           | 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Calculus Micro Observation Only      | X                             X                                          |      3     |
      Inflammation, Chronic                | 1  1  1  1     1  1  1  1  1  1  1     1        1  1  2     1           1|     35  1.0|
      Inflammation, Chronic Active         |                                                          2               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +           M                    +                        |             
      Necrosis                             |                                                 3                        |             
      Adventitia, Inflammation, Acute      |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +     +  +  +  +  +     +        +  +     +  +  +        +     +      |             
      Calculus Micro Observation Only      |                            X                                             |             
      Fibrosis                             |                            3                                             |             
      Inflammation, Chronic Active         |                            4                                             |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +           +     +              +                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +           +                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +           +                    +                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +           +                    M                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +           +     +              +           +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +           +                    +                        |             
      Epithelium, Hyperplasia              |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +           +     +              +           +            |             
      Hyperplasia, Lymphoid                |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +           +                    M                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                            4                                             |             
      Basophilic Focus                     |                                  2                                       |             
      Degeneration                         | 1  2        1     1  2  2                 1  1              1        1  1|             
      Eosinophilic Focus                   |                2                                                         |             
      Fatty Change                         |                2  1                                                      |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Hemorrhage                           |    3                 2           1           1              1  1        1|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |             1        1  2              1                       1         |             
      Inflammation, Chronic Active         |                            4                                             |             
      Mixed Cell Focus                     |    2                                                                     |             
      Necrosis, Coagulative                |    2                 1     4     1                       1  1            |             
      Pigmentation                         |                      1                                                   |             
      Regeneration                         |                            1                                             |             
      Centrilobular, Cytomegaly            | 2  2     3  4  2  4  4  3        2        2  1     3     3  3  1     3  2|             
      Centrilobular, Karyomegaly           | 1  2     2  2  1  2  2  1        1        2  1     2     2  2  1     2  1|             
      Periportal, Inflammation, Chronic    |                                                             1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                            +            |             
      Fibrosis                             |                                                             2            |             
      Inflammation, Chronic                |                                                             2            |             
      Inflammation, Chronic Active         |                4                                                         |             
      Necrosis, Coagulative                |                4                                            4            |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +           +                    +           +        +   |             
      Inflammation, Chronic Active         |                4                                            1            |             
      Necrosis, Coagulative                |                3                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +           +                    M                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |                1                                                         |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +           +                    +                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +           +                    +                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +           +                    +                        |             
      Inflammation, Chronic                |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +           +                    +                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +           +                    +                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +           +                    +                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +           +                    +                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +           +                    +                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +           M                    +                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +           +                    +                        |             
      Pars Distalis, Cyst                  |                            1                                             |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +           +                    +                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                +           +                          +                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                    +              +  +                    +     +  +   |             
      Abscess                              |                                        4                             4   |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                | 2                                                                        |             
      Inflammation, Chronic Active         |                                     3                             4      |             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |                      4                                      4            |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                +           +                    +                        |             
      Inflammation, Chronic                |                1                                                         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +           +                    +                        |             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |                +           +                    +     +                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +           +                    +                        |             
      Congestion                           |                                                 2                        |             
      Infarct                              |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +        +  +     +     +     +  M              +  +  +   |             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                      4   |             
      Renal, Hemorrhage                    |                                  1                                       |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +           M                    M                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +           M        +  +     +     +     +  M                 +      |             
      Angiectasis                          |    2                             1                                2      |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hemorrhage                           |    2                    3              4                          2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +        +           +     +           +  +              +         |             
      Hematopoietic Cell Proliferation     |                3           3                 3                           |             
      Hyperplasia, Lymphoid                |       4                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +           +                    M                        |             
      Depletion Lymphoid                   |                3           2                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                M           M                    M                        |             
                                            __________________________________________________________________________|             
   Skin                                    |                +           +  +     +        +  +                        |             
      Inflammation, Acute, Necrotizing     |                                              4                           |             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |                                     4                                    |             
      Epidermis, Inflammation, Acute       |                               1                                          |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +     +           +  +  +     +  +  +  +  +  +  +  +           +|             
      Joint, Tarsal, Hyperostosis          |    4  4  4                    4  4     4  4  4     4  4  4  4           4|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +           +                    +                        |             
      Hemorrhage                           |                                                                          |             
      Thalamus, Mineralization             |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +           +  +        +  +                    +                        |             
      Congestion                           |             1                                   2                        |             
      Hemorrhage                           |                1                                1                        |             
      Fat, Mediastinum, Necrosis,          |                                                                          |             
          Liquifactive                     |                2                                                         |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +           +                                             |             
      Glands, Inflammation, Acute          |                            2                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +           +                    +                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +        M           +                           |             
      Hyperplasia                          |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |          4                 3                 1                 2         |             
      Inflammation, Chronic                | 2  1  1     1  1  1  1  1  2  2  1  1  1           1  1  1  1     1  1  1|             
      Inflammation, Chronic Active         |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Degeneration                    |                3                                                         |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Regeneration                    |    2           3           4                                             |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +           +                    +                        |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9|            |
                                           | 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.15                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                               +     +                                    |   4        |
      Necrosis                             |                                                                          |      1  3.0|
      Adventitia, Inflammation, Acute      |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             |             +  +              +     +                       +            |  20        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                               +     +                                    |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                               +                                          |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                               +     +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                               +     M                                    |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +                             +     +  +                                 |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                               +     +                                    |   5        |
      Epithelium, Hyperplasia              |                               3                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                             +     +  +                                 |   9        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                               +     M                                    |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                          |      1  4.0|
      Basophilic Focus                     |                                                                          |      1  2.0|
      Degeneration                         |                         1  1           2  1        2  2  2  2  1  1  3   |     22  1.5|
      Eosinophilic Focus                   |             2                                                            |      2  2.0|
      Fatty Change                         |             2                       1     1           1  1               |      7  1.3|
      Hematopoietic Cell Proliferation     | 1                       1                                               1|      4  1.3|
      Hemorrhage                           |                   1     1              2  1           3  3  3     2  4   |     16  1.9|
      Inflammation, Acute                  |                   1                                                      |      1  1.0|
      Inflammation, Chronic                |                                           1                              |      6  1.2|
      Inflammation, Chronic Active         |             1        1                             1        1            |      5  1.6|
      Mixed Cell Focus                     |                                                             2            |      2  2.0|
      Necrosis, Coagulative                |             1     1              2     1              1                  |     11  1.5|
      Pigmentation                         |                                                                          |      1  1.0|
      Regeneration                         |                                                                          |      1  1.0|
      Centrilobular, Cytomegaly            |    2  1  2        3        2  2        2  2  2     2  4  3  4  2  3  4  1|     34  2.5|
      Centrilobular, Karyomegaly           |    1  1  2        2        2  2        2  1  2     2  2  2  3  2  2  3  1|     34  1.7|
      Periportal, Inflammation, Chronic    |                                                       1                  |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9|            |
                                           | 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.15                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis, Coagulative                |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                               +     +                             +      |   8        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                               +     +                                    |   4        |
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                               +     +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                               +     +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                               +     +                                    |   5        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                               +     +                                    |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                               +  +  +           +                       +|   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                               +  +  +           +                       +|   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                               +  +  +           +                       +|   8        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                               +     +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                               +     M                                    |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                               +     +                                    |   5        |
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                               +     +                                    |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                               +                                          |   4        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +     +  +        +              +        +                     |  14        |
      Abscess                              |       4                                            4                     |      4  4.0|
      Cyst                                 |                   4                                                      |      1  4.0|
      Inflammation, Chronic                |                                           2                              |      2  2.0|
      Inflammation, Chronic Active         |          2     2                                                         |      4  2.8|
      Inflammation, Chronic Active,        |                                                                          |            |
          Necrotizing                      |                                                                          |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9|            |
                                           | 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.15                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Duct, Dilatation                     |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                               +     +                                    |   5        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                               +     +        +                           |   6        |
      Atrophy                              |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                         +     +     +                                    |   7        |
      Inflammation, Chronic Active         |                         4                                                |      1  4.0|
      Seminiferous Tubule, Atrophy         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                               +     +                                    |   5        |
      Congestion                           |                                                                          |      1  2.0|
      Infarct                              |                               2                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +     +  +  +  +  +  +  +        +  +        +     +  +  +|  27        |
      Axillary, Hyperplasia, Lymphoid      |                                                                         4|      1  4.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                                         2|      1  2.0|
      Lumbar, Hyperplasia, Plasma Cell     |                         3                                                |      1  3.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  4.0|
      Renal, Hemorrhage                    |                                                                          |      1  1.0|
      Renal, Hyperplasia, Lymphoid         |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                               M     M                                    |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +     +     +     +  +     +  +           +        +     +  +   |  20        |
      Angiectasis                          |                                                                          |      3  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |    2     2     3     2     2           3           3        3     2  3   |     14  2.6|
      Hyperplasia, Lymphoid                |                               2                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                             1            |      1  1.0|
      Pigmentation                         |                                                             1            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +        +  +  +  +  +  +        +  +                 +     +|  20        |
      Hematopoietic Cell Proliferation     |                         2                    2                           |      5  2.6|
      Hyperplasia, Lymphoid                |          3                                                              3|      3  3.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                               +     +                                    |   4        |
      Depletion Lymphoid                   |                               3     1                                    |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                               M     M                                    |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                      +  +     +     +                                   +|  11        |
      Inflammation, Acute, Necrotizing     |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9|            |
                                           | 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.15                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active,        |                                                                          |            |
          Necrotizing                      |                         4                                                |      2  4.0|
      Epidermis, Inflammation, Acute       |                                                                          |      1  1.0|
      Subcutaneous Tissue, Abscess         |                                                                         4|      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +        +  +     +  +  +  +  +  +  +  +        +           +|  33        |
      Joint, Tarsal, Hyperostosis          | 4  4  4  3  4        4  4        2     4  4  4  4  4        4           3|     28  3.9|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                               +     +                                    |   5        |
      Hemorrhage                           |                                     2                                    |      1  2.0|
      Thalamus, Mineralization             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +              +  +  +     +              +  +  +         |  14        |
      Congestion                           |                                     3                                    |      3  2.0|
      Hemorrhage                           |                                                          1     1         |      4  1.0|
      Fat, Mediastinum, Necrosis,          |                                                                          |            |
          Liquifactive                     |                                                                          |      1  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic                          |                                           2                              |      1  2.0|
      Perivascular, Inflammation, Chronic  |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                               +                                          |   3        |
      Glands, Inflammation, Acute          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                               +     +                                    |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Hyperplasia                          |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glomerulosclerosis                   |                         2        3                                       |      6  2.5|
      Inflammation, Chronic                | 2  2  2  2  2  1  1  1  1  1           1  2  2  1  2  3  1  3  2  2  2  3|     42  1.5|
      Inflammation, Chronic Active         |                               2                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9|            |
                                           | 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.15                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Degeneration                    |                                                                          |      1  3.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Regeneration                    |                                                                          |      3  3.0|
      Transitional Epithelium, Hyperplasia |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                               +     +     +                              |   6        |
      Inflammation, Chronic                |                               1           2                              |      2  1.5|
      Mineralization                       |                                     1                                    |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  M  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  M  +  M  +  +  +  +|             
      Inflammation, Chronic                |    1                 1           1        1  1                           |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                 2                        |             
      Epithelium, Hyperplasia              |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphoid Tissue, Necrosis            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                        2                                 |             
      Peyer's Patch, Inflammation, Chronic |                                                                          |             
          Active                           |                                        3                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                2                                                         |             
      Clear Cell Focus                     |          1        1                          2  2        2               |             
      Cyst                                 |                                                                          |             
      Degeneration                         |    2  2  2  2     2  2     3     1  2  2  2  2  3  2     2  2  1  2  2   |             
      Eosinophilic Focus                   |                                                          2               |             
      Fatty Change                         |          2                             1  1  2  2        1  1        2   |             
      Hemorrhage                           |                   2  1           1  1  2  2  2  2  1     1  2  1  2  2   |             
      Inflammation, Chronic                | 1     1                 1     1                                      1   |             
      Inflammation, Chronic Active         |                                                                          |             
      Karyomegaly                          |                                                                          |             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |                            3                                             |             
      Necrosis, Coagulative                |    1  1  1  1     1  1              1  1  1  1  1  1  1  1  2     1  1  2|             
      Pigmentation                         |    1     1           1     1           1     1  1  1  1  1  1     1      |             
      Centrilobular, Cytomegaly            | 1  2  2  3  1  2  2  3     2  2     2  2  2  3  3  2  2  2  2  1  2  2  1|             
      Centrilobular, Karyomegaly           | 1  2  2  3  1  2  2  3     2  2     2  2  2  3  2  2  2  1  2  1  2  2  1|             
      Periportal, Inflammation, Chronic    |                      1                          1                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Fibrosis                             |                                              2                           |             
      Inflammation, Chronic                |                                              2                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |    1     1           1           1  1  1                    1     1     1|             
      Inflammation, Chronic Active         |                                              1                           |             
      Artery, Mineralization               |                      1                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Inflammation, Chronic |                                                             1            |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |    1  1  1  1  1     1     1  1  1  1  1  1  1  1  1     1  1  1  1     1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                     1                                    |             
      Hyperkeratosis                       |                                     1  2              1                  |             
      Hyperplasia, Basal Cell              |                                        2                                 |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Inflammation, Chronic                |                      1                                                   |             
      Inflammation, Chronic Active         |                               1                       1                 2|             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |                                     1                                    |             
      Muscularis, Mineralization           |                      1                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                 1                        |             
      Inflammation, Chronic                |          1                 1                             1        1  1   |             
      Inflammation, Chronic Active         |                                                    2  1     1  1         |             
      Pigmentation                         |                                                                          |             
      Muscularis, Mineralization           |                      1                                                   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +           +                                 |             
      Incisor, Abscess                     |                            3           2                                 |             
      Incisor, Bacterium                   |                                                                          |             
      Incisor, Dysplasia                   |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                               1                                          |             
      Inflammation, Chronic                |       1                                                  1     1         |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                      2               |             
      Pigmentation                         |          1        1                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  M  M  +  +  +  +|             
      Vacuolization Cytoplasmic            |                                     2                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                             1            |             
      Pars Distalis, Hyperplasia           |                   1        1                 2              1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                     1                                    |             
      Follicle, Cyst                       |    1  1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |    +        +                          +  +     +  +        +  +         |             
      Inflammation, Chronic                |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                 1                        |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1  1  1  2     1  1        1              2  1           1  2         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                                            +     +         |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |             1                                            2     2         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |    1  1  1           1        1  1  1  1  1  1  1  1  1  1  1  1     1  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |       2           1                 1  1                    1            |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        1                                1|             
      Seminiferous Tubule, Atrophy         |                1                                                         |             
      Seminiferous Tubule, Giant Cell      |                                                                          |             
      Seminiferous Tubule, Mineralization  |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Plasma Cell   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Bronchial, Hyperplasia, Lymphoid     |             2                                                            |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Inguinal, Inflammation, Acute        |                                                                          |             
      Inguinal, Pigmentation               |                            1                                             |             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Depletion Lymphoid      |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |                                     2                                    |             
      Pancreatic, Angiectasis              |                                                       2                  |             
      Pancreatic, Depletion Lymphoid       |                                                       3                  |             
      Pancreatic, Ectasia                  |                                                       3                  |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  +  +  M  +  +  M  +  M  M  M  +  M  +  M  M  M|             
      Hyperplasia, Lymphoid                |                                     2                                    |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |       2  3  2        2     2  2  1     2           2     2  1     2     1|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                         3                                                |             
      Hemorrhage                           |                1        2                                                |             
      Hyperplasia, Lymphoid                |    2  1                                         2           1            |             
      Infiltration Cellular, Histiocyte    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                  2                 2                     |             
      Hematopoietic Cell Proliferation     |                2        2  2                          2                  |             
      Hyperplasia, Lymphoid                |    2                                   2           2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  M  +  +  M  M  M  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +|             
      Cyst                                 |    1     1                       1        1                              |             
      Depletion Lymphoid                   |                                  1     3                                 |             
      Hemorrhage                           |                                           1     1                        |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                         3|             
      Inflammation, Acute, Hemorrhagic     |                                                                          |             
      Inflammation, Acute                  |                1     1              1     2                              |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Inflammation, Chronic                |                                  1                                       |             
      Inflammation, Chronic Active         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
      Subcutaneous Tissue, Granuloma       |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          | 4  4  4           4  4     4     4  4  4     4     4  3  4  4  4  4     4|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             |             1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus Tumor                        |                                                       X                  |             
      Hemorrhage                           |                                     1           2        1               |             
      Infiltration Cellular, Histiocyte    |                         2                                            1   |             
      Inflammation, Acute                  |                         2                                                |             
      Inflammation, Chronic                |       1                                                                  |             
      Inflammation, Chronic Active         |                                     2                          1         |             
      Alveolar Epithelium, Hyperplasia     |       2                    1                                             |             
      Perivascular, Inflammation, Chronic  |                                        1                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Lumen, Inflammation, Acute           |                                                       2                  |             
      Mucosa, Inflammation, Acute          |    1  1              1        1        1     1  1           1     1  1  1|             
      Mucosa, Inflammation, Chronic        |                                                       2                  |             
      Mucosa, Inflammation, Chronic Active |                                  1                                       |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                         2                                                |             
      Nasolacrimal Duct, Metaplasia,       |                                                                          |             
          Squamous                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                       +         |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |                         2  2                                   1         |             
      Infarct                              |                                              2                           |             
      Inflammation, Chronic                | 1  1  2  1  1  2  1  1     1  1  1  1  1  1  1  2  1     1  1  1  1  2  2|             
      Inflammation, Chronic Active         |                                                       2                  |             
      Medulla, Mineralization              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Regeneration                    |    1  2  1  1     1  1     1  1  1  1  1  1  2     1     1  1  1  1     1|             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                      +   |             
      Inflammation, Chronic                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                      +        +                          +        +      |             
      Calculus Micro Observation Only      |                      1                                   X        3      |             
      Inflammation, Chronic                |                               1                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |    X                                                                     |             
      Calculus Micro Observation Only      |       2                          2        X                              |             
      Inflammation, Chronic                |    1  1  1  1     1  1     1  1  1  1  1     1  1  1     1  1  1  1  1  1|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3|            |
                                           | 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.3 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  +|  39        |
      Inflammation, Chronic                |                                                             1            |      6  1.0|
      Epithelium, Hyperplasia              |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                  2                                       |      1  2.0|
      Lymphoid Tissue, Necrosis            |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Peyer's Patch, Inflammation, Chronic |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                     2                                    |      2  2.0|
      Clear Cell Focus                     |                                                                          |      5  1.6|
      Cyst                                 |                3                                                         |      1  3.0|
      Degeneration                         |    2           2  2  2  1  2  2  1  2  2  1     2  2  2  2  2  2  1     2|     38  1.9|
      Eosinophilic Focus                   |                                        1                                 |      2  1.5|
      Fatty Change                         |          1  2  3           2  2  1  2     1     2  2              1     2|     20  1.7|
      Hemorrhage                           |                2     2  2  1  2  1     2  1     2  2        1  1        2|     27  1.6|
      Inflammation, Chronic                |    2                             1           2                           |      8  1.3|
      Inflammation, Chronic Active         |                1        2     1     2           1  1  1                 1|      8  1.3|
      Karyomegaly                          |                                                                         2|      1  2.0|
      Mineralization                       |                         1                                                |      1  1.0|
      Mixed Cell Focus                     |    X                                                                     |      2  3.0|
      Necrosis, Coagulative                | 1  2           1     1  2  1  1     1  1  1  1  1  1  1  1     1  1     1|     36  1.1|
      Pigmentation                         |    1           1     1  1  1  1     1     1  1  1  1  2  1              1|     26  1.0|
      Centrilobular, Cytomegaly            | 2  2     3  3  2  2  2  2  2  2  1  2  2  1  2  2  2  1  2     2  2     2|     45  2.0|
      Centrilobular, Karyomegaly           | 1  2     2  2  2  2  2  2  2  2  1  2  2  1  2  2  2  1  2     2  2      |     44  1.9|
      Periportal, Inflammation, Chronic    |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3|            |
                                           | 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.3 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
      Pigmentation                         |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |             1                                                            |      1  1.0|
      Inflammation, Chronic                |                                                                1  1      |     11  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Artery, Mineralization               |                   1                                                      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parotid Gland, Inflammation, Chronic |                                                                          |      1  1.0|
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic                          |                         1                                                |      1  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         | 1  1     1     1  1  1  1  1  1  1  1     1  1     1     1  1  2  1  1  1|     40  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                   1           2     2                                    |      4  1.5|
      Hyperkeratosis                       |                2  1           2                                          |      6  1.5|
      Hyperplasia, Basal Cell              |                               2     1                                    |      3  1.7|
      Inflammation, Acute, Necrotizing     |                               2                                          |      1  2.0|
      Inflammation, Chronic                |                   1                                                      |      2  1.0|
      Inflammation, Chronic Active         |                                     1                                    |      4  1.3|
      Inflammation, Chronic Active,        |                                                                          |            |
          Necrotizing                      |                                                                          |      1  1.0|
      Muscularis, Mineralization           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                   1              1                                      1|      8  1.0|
      Inflammation, Chronic Active         |                                     1                                    |      5  1.2|
      Pigmentation                         |             1                                                            |      1  1.0|
      Muscularis, Mineralization           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +     +                                   +                              |   5        |
      Incisor, Abscess                     | 3     4                                                                  |      4  3.0|
      Incisor, Bacterium                   | 3                                                                        |      1  3.0|
      Incisor, Dysplasia                   |                                           1                              |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3|            |
                                           | 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.3 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      3  1.0|
      Inflammation, Chronic Active         |                                           1                              |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Hyperplasia                          |                                                                          |      2  2.0|
      Pigmentation                         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Hyperplasia                          |          3              1  1                                             |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  M  M  +  +  +  +  +  +  M  +  M  +  M  M  +  +  +|  34        |
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  45        |
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |                                           2              1               |      6  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Follicle, Cyst                       |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                               +  +        +                              |  11        |
      Inflammation, Chronic                |                                  2                                       |      1  2.0|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                1        1        2        1  2           1     1  1     2|     20  1.3|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +  +              +                 +        +   |   8        |
      Hemorrhage                           |                                                                      2   |      1  2.0|
      Inflammation, Chronic                |                                                             2            |      1  2.0|
      Inflammation, Chronic Active         |                         2                 2                              |      5  1.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                      2   |      1  2.0|
      Inflammation, Acute                  |                                                                      2   |      1  2.0|
      Inflammation, Chronic                |    1           1  1     1     1  2     1  1  1     1  1  1  1  1  1      |     33  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3|            |
                                           | 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.3 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                    2                     |      1  2.0|
      Inflammation, Chronic                |                                              1                 1  1      |      8  1.1|
      Inflammation, Chronic Active         |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Seminiferous Tubule, Atrophy         |       1  1                                                               |      3  1.0|
      Seminiferous Tubule, Giant Cell      |          1                                                               |      1  1.0|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |          2  2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Hyperplasia, Plasma Cell   |                                                          2               |      1  2.0|
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Plasma Cell   |                                                          2               |      1  2.0|
      Inguinal, Inflammation, Acute        |                                                          1               |      1  1.0|
      Inguinal, Pigmentation               |                                        1                                 |      2  1.0|
      Mediastinal, Angiectasis             |                2                                                         |      1  2.0|
      Mediastinal, Depletion Lymphoid      |       2                                                                  |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                2         |      1  2.0|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
      Pancreatic, Angiectasis              |                                                                          |      1  2.0|
      Pancreatic, Depletion Lymphoid       |                                                                          |      1  3.0|
      Pancreatic, Ectasia                  |                                                                          |      1  3.0|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M  M  +  +  M  +  +  +  +  M  +  +  M  +  M  M  +  +  +  +  M  +  +|  23        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation                         |                                     1        1                           |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Angiectasis                          |    2     1        1  1  1     1  1  2  2     2  2  1     2  2  1  3     1|     30  1.7|
      Depletion Lymphoid                   |       1                                                           3      |      2  2.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hemorrhage                           |       1                                                                  |      3  1.3|
      Hyperplasia, Lymphoid                |                                                             2            |      5  1.6|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3|            |
                                           | 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.3 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Depletion Lymphoid                   |       3  2                          2                                    |      5  2.2|
      Hematopoietic Cell Proliferation     |       4                                                  2        3      |      7  2.4|
      Hyperplasia, Lymphoid                |                                              1              2  2         |      6  1.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  M  +  M  M  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +|  34        |
      Cyst                                 |    1                       1                    1                        |      7  1.0|
      Depletion Lymphoid                   |          4                                                        2      |      4  2.5|
      Hemorrhage                           |                                                                          |      2  1.0|
      Necrosis                             |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                                                      2   |      1  2.0|
      Cyst                                 |                            2                                             |      1  2.0|
      Hemorrhage                           | 4                                                                    4   |      3  3.7|
      Inflammation, Acute, Hemorrhagic     |                            2                                             |      1  2.0|
      Inflammation, Acute                  | 1                                                                    4   |      6  1.7|
      Inflammation, Acute, Necrotizing     |    4           4                                                  4     4|      4  4.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Subcutaneous Tissue, Fibrosis        |                3                                                         |      1  3.0|
      Subcutaneous Tissue, Granuloma       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Joint, Tarsal, Hyperostosis          | 4  4  3        4     4  4  4  4     2  4  4  4     4  4  4  4     4     3|     35  3.9|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thalamus, Mineralization             | 1  1  1  1        1  1  1  1  1     2  1  1     1  1  1  1  1  1  1      |     40  1.1|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Embolus Tumor                        |                                                                          |      1     |
      Hemorrhage                           |          1        1                                                      |      5  1.2|
      Infiltration Cellular, Histiocyte    |                                        2           1                 1   |      5  1.4|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                            2                    1                        |      4  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05063-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 08:17:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3|            |
                                           | 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.3 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |          1                                                               |      3  1.3|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lumen, Inflammation, Acute           |                                                       2                  |      2  2.0|
      Mucosa, Inflammation, Acute          |                   1  1        1  1  1              2           1         |     18  1.1|
      Mucosa, Inflammation, Chronic        |                                                                          |      1  2.0|
      Mucosa, Inflammation, Chronic Active |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                       2        2         |      3  2.0|
      Nasolacrimal Duct, Metaplasia,       |                                                                          |            |
          Squamous                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   3        |
      Hyperplasia                          |                                                       1                  |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glomerulosclerosis                   |                2        2                                1               |      6  1.7|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Chronic                | 1  1  1  1     1  1  2  2  1  1  1  1  2  1  1  2  1  2  2  1  2  1  1  2|     47  1.3|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Medulla, Mineralization              |          2                                                               |      1  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Regeneration                    | 1  1           1  1     1  1     1  1  1  1        1  1  1  1  2  1     1|     36  1.1|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                         +  +                                      +      |   7        |
      Calculus Micro Observation Only      |                         X  X                                      X      |      6  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      3  2.0|
      Inflammation, Chronic                |    1     1           1  1     1              1     1     1     1  1      |     30  1.0|
      Inflammation, Chronic Active         |                                                 1                        |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.