National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2858

TDMS Study 05069-08 Pathology Tables

                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-08                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/23/95
Route: DERMAL,SOLUTION                                                                                            Time: 17:13:00


                                                       CORE STUDY (REV.1)


       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  08/21/92

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25026 Other                             25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All






























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1
NTP Experiment-Test: 05069-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 05/23/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:13:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19           10            9            9                                     
    Natural Death                                     12           19           19           19                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                19           21           22           22                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (47)         (48)         (47)                                   
   Intestine Large, Rectum                            (49)         (47)         (47)         (46)                                   
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (41)         (44)         (44)                                   
      Carcinoma                                                                               1 (2%)                                
   Intestine Small, Ileum                             (45)         (40)         (42)         (40)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Hepatocellular Adenoma                                        2 (4%)                                                          
      Sarcoma, Metastatic, Spleen                                                1 (2%)                                             
   Mesentery                                          (8)          (8)          (4)          (3)                                    
      Carcinoma, Metastatic, Uncertain Primary Site    1 (13%)                                                                      
      Schwannoma Malignant, Metastatic, Uterus                                   1 (25%)                                            
   Oral Mucosa                                        (1)          (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
      Pharyngeal, Squamous Cell Papilloma              1 (100%)                                                                     
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Sarcoma, Metastatic, Spleen                                                1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant, Metastatic, Harderian                                                                                   
          Gland                                        1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (49)         (50)                                   
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05069-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 05/23/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:13:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          3 (6%)       1 (2%)       1 (2%)       1 (2%)                                
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (49)         (50)         (50)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
      Pars Distalis, Adenoma                          30 (61%)     28 (56%)     31 (62%)     33 (66%)                               
      Pars Distalis, Carcinoma                         2 (4%)                    2 (4%)       1 (2%)                                
   Thyroid Gland                                      (49)         (50)         (48)         (49)                                   
      C-Cell, Adenoma                                  7 (14%)      5 (10%)      2 (4%)       2 (4%)                                
      C-Cell, Carcinoma                                                          1 (2%)                                             
      Follicular Cell, Adenoma                         1 (2%)       2 (4%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (46)         (45)         (49)                                   
      Adenoma                                          4 (8%)       2 (4%)       5 (11%)      2 (4%)                                
      Carcinoma                                        1 (2%)                                                                       
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                                                                       
   Ovary                                              (50)         (50)         (50)         (50)                                   
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Polyp Stromal                                    4 (8%)       3 (6%)       4 (8%)                                             
      Sarcoma Stromal                                               1 (2%)                    1 (2%)                                
      Schwannoma Malignant                             1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Vagina                                                          (1)          (2)                                                 
      Sarcoma Stromal, Metastatic, Uterus                           1 (100%)                                                        
      Schwannoma Malignant, Metastatic, Uterus                                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (50)                                   
   Lymph Node                                         (13)         (10)         (7)          (1)                                    
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (14%)                                            
      Mediastinal, Sarcoma, Metastatic, Spleen                                   1 (14%)                                            
                                                             Page   3                                                               
NTP Experiment-Test: 05069-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 05/23/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:13:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant, Metastatic, Harderian                                                                                   
          Gland                                        1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (49)         (50)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Sarcoma                                                                    1 (2%)                                             
   Thymus                                             (47)         (50)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)         (49)         (50)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
      Adenoma, Multiple                                1 (2%)                                                                       
      Carcinoma                                        3 (6%)       5 (10%)                   2 (4%)                                
      Carcinoma, Multiple                                                                     1 (2%)                                
      Fibroadenoma                                    18 (38%)     10 (20%)     12 (24%)     15 (30%)                               
      Fibroadenoma, Multiple                           7 (15%)      6 (12%)      3 (6%)       1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Fibroma                                          1 (2%)                                                                       
      Melanoma Benign                                  1 (2%)                                                                       
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Pinna, Melanoma Malignant                                     1 (2%)                                                          
      Skin, Site of Application, Keratoacanthoma                    1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Skeletal Muscle                                                              (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                                      1 (2%)                                             
      Carcinoma, Metastatic, Pituitary Gland           2 (4%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05069-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 05/23/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:13:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                    1 (2%)                                             
      Carcinoma, Metastatic, Mammary Gland                          1 (2%)                                                          
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Sarcoma, Metastatic, Spleen                                                1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (49)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                                                                           
      Nerve, Schwannoma Malignant                      1 (100%)                                                                     
   Zymbal's Gland                                     (1)                       (1)          (1)                                    
      Carcinoma                                        1 (100%)                  1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
   Urinary Bladder                                    (50)         (48)         (49)         (50)                                   
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
      Transitional Epithelium, Papilloma, Multiple                  1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Granulocytic                            1 (2%)                                                                       
      Leukemia Mononuclear                            22 (44%)     16 (32%)     23 (46%)     10 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05069-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 05/23/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:13:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          43          47          43                                       
     Total Primary Neoplasms                          117          90          94          80                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          37          37          38                                       
     Total Benign Neoplasms                            81          62          62          59                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          26          28          18                                       
     Total Malignant Neoplasms                         36          28          32          21                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           3           6           1                                       
     Total Metastatic Neoplasm                          6           4          13           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05069-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 05/23/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:13:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Natural Death                                     21           26           25           23                                     
    Moribund Sacrifice                                24           22           20           26                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 5            2            4            1                                     
  Other                                                                          1                                                  
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (47)         (47)         (42)         (44)                                   
      Fibroma                                          1 (2%)                                                                       
   Intestine Large, Rectum                            (47)         (49)         (49)         (45)                                   
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                                              1 (2%)                                
   Intestine Large, Cecum                             (42)         (44)         (36)         (39)                                   
   Intestine Small, Duodenum                          (50)         (50)         (46)         (48)                                   
   Intestine Small, Jejunum                           (46)         (45)         (42)         (39)                                   
   Intestine Small, Ileum                             (40)         (37)         (34)         (37)                                   
      Fibrosarcoma                                                  1 (3%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                                              1 (2%)                                
      Hepatocellular Carcinoma                         1 (2%)                    2 (4%)       1 (2%)                                
      Hepatocellular Adenoma                                        2 (4%)                                                          
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Mesentery                                          (10)         (3)          (3)          (4)                                    
   Oral Mucosa                                                                               (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                                              1 (2%)                                
      Mixed Tumor Benign                                            1 (2%)                                                          
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
   Tongue                                                                       (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05069-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 05/23/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:13:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                       (1)                                    
      Aorta, Osteosarcoma, Metastatic, Bone                         1 (100%)                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Pheochromocytoma Malignant                                    2 (4%)                                                          
      Pheochromocytoma Benign                          2 (4%)       7 (14%)      5 (10%)      2 (4%)                                
      Bilateral, Pheochromocytoma Benign               3 (6%)                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Adenoma                                          6 (12%)      2 (4%)                    3 (6%)                                
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (48)         (49)         (46)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (49)         (50)         (50)         (49)                                   
      Pars Distalis, Adenoma                          25 (51%)     23 (46%)     18 (36%)     18 (37%)                               
      Pars Distalis, Adenoma, Multiple                                           1 (2%)                                             
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                               1 (2%)                                                          
      Follicular Cell, Adenoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                                              1 (2%)                                
   Preputial Gland                                    (50)         (49)         (49)         (49)                                   
      Adenoma                                          1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
      Carcinoma                                                     1 (2%)       1 (2%)       2 (4%)                                
   Prostate                                           (50)         (50)         (50)         (49)                                   
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                                              1 (2%)                                
                                                             Page   8                                                               
NTP Experiment-Test: 05069-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 05/23/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:13:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                                              1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           18 (36%)     32 (64%)     24 (48%)     27 (54%)                               
      Interstitial Cell, Adenoma                      18 (36%)      9 (18%)     13 (26%)     14 (28%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (19)         (15)         (6)          (9)                                    
   Lymph Node, Mandibular                             (49)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                                              1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                                              1 (2%)                                
      Lipoma                                                                     1 (2%)                                             
   Thymus                                             (45)         (44)         (49)         (46)                                   
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                                              1 (2%)                                
      Thymoma Benign                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (42)         (42)         (45)         (40)                                   
      Adenoma                                                                    2 (4%)                                             
      Fibroadenoma                                                  1 (2%)                    1 (3%)                                
   Skin                                               (50)         (50)         (49)         (50)                                   
      Basal Cell Adenoma                                                         1 (2%)                                             
      Keratoacanthoma                                  1 (2%)       1 (2%)       1 (2%)                                             
      Squamous Cell Papilloma                                       1 (2%)       2 (4%)       1 (2%)                                
      Pinna, Melanoma Malignant                                                  1 (2%)                                             
      Pinna, Squamous Cell Papilloma                   1 (2%)       1 (2%)                    2 (4%)                                
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Adenoma                                                  1 (2%)                                                          
      Skin, Site of Application, Keratoacanthoma       1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Fibroma, Multiple                                     1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                                             1 (2%)                                
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Fibroma                                      1 (2%)                                                          
      Subcutaneous Tissue, Skin, Site of                                                                                            
                                                             Page   9                                                               
NTP Experiment-Test: 05069-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 05/23/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:13:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
          Application, Fibrosarcoma                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)                                                          
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
      Osteosarcoma                                                  1 (2%)       1 (2%)                                             
      Turbinate, Chondroma                                                                    1 (2%)                                
      Vertebra, Fibrosarcoma                                        1 (2%)                                                          
   Skeletal Muscle                                                 (1)          (2)          (1)                                    
      Fibrosarcoma, Metastatic, Bone                                1 (100%)                                                        
      Fibrous Histiocytoma                                                                    1 (100%)                              
      Osteosarcoma                                                               1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                            1 (2%)                    1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                               1 (2%)                                             
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                                              1 (2%)                                
      Melanoma Malignant, Metastatic, Skin                                       1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
      Osteosarcoma, Metastatic, Skeletal Muscle                                  1 (2%)                                             
   Nose                                               (50)         (49)         (50)         (50)                                   
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Glands, Adenoma                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (3)          (1)          (2)          (2)                                    
      Carcinoma, Metastatic, Zymbal's Gland                         1 (100%)                                                        
   Zymbal's Gland                                     (1)          (1)                       (1)                                    
      Carcinoma                                        1 (100%)     1 (100%)                  1 (100%)                              
                                                             Page  10                                                               
NTP Experiment-Test: 05069-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 05/23/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:13:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Sarcoma                                                                                 1 (2%)                                
      Renal Tubule, Adenoma                            1 (2%)       7 (14%)      8 (16%)      7 (14%)                               
      Renal Tubule, Adenoma, Multiple                                            2 (4%)                                             
      Renal Tubule, Adenoma, Oncocytic                                                        1 (2%)                                
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
   Urinary Bladder                                    (49)         (50)         (50)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            25 (50%)     25 (50%)     17 (34%)     14 (28%)                               
      Mesothelioma Malignant                           1 (2%)       4 (8%)       2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05069-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 05/23/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:13:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          50          46          49                                       
     Total Primary Neoplasms                          109         134         114         105                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          50          45          47                                       
     Total Benign Neoplasms                            80          95          87          80                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          34          23          21                                       
     Total Malignant Neoplasms                         29          39          27          25                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           7           6           2                                       
     Total Metastatic Neoplasm                          1          30          16          14                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.