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TDMS Study 05069-08 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-08                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 03/13/95
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42


                                                           CORE STUDY


       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  08/21/92

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25026 Other                             25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All
































                                                             Page   1
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 0| 0| 3| 1| 3| 3| 2| 9| 3| 3| 3| 2| 2| 7| 1| 3| 8| 3| 2| 3| 3| 3| 6| 3| 0|             
                                           | 6| 2| 7| 9| 7| 4| 7| 8| 7| 7| 7| 5| 9| 6| 6| 7| 1| 7| 3| 7| 7| 7| 8| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       2                  |             
      Basophilic Focus                     |       X     X  X     X     X  X  X  X  X  X  X     X     X  X  X  X  X  X|             
      Clear Cell Focus                     |                                              X           X     X     X   |             
      Eosinophilic Focus                   |       X                    X           X  X        X     X           X   |             
      Hematopoietic Cell Proliferation     |    2                                                                    1|             
      Hepatodiaphragmatic Nodule           |             X                 X     X  X        X                        |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |       X                 X                 X                              |             
      Centrilobular, Necrosis              |    2                                                                     |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      | 3  3     3                                      3     3                 3|             
      Periportal, Vacuolization Cytoplasmic|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                            +              +         |             
      Fat, Necrosis                        |    2                                                           2         |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                         2|             
      Acinus, Atrophy                      | 2     2  1  1     2                 1              1           1  1  1  3|             
      Artery, Thrombosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |          2  1     2                             2     3                  |             
      Inflammation, Chronic                |          2        3                             2     3                  |             
      Ulcer                                |          4        4                             3                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              | 2  2     2        2              3              2     3                  |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  1  1     1     2  1  1  2     1  1  1  2  1  2     1  1  2  1  1  1|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 0| 0| 3| 1| 3| 3| 2| 9| 3| 3| 3| 2| 2| 7| 1| 3| 8| 3| 2| 3| 3| 3| 6| 3| 0|             
                                           | 6| 2| 7| 9| 7| 4| 7| 8| 7| 7| 7| 5| 9| 6| 6| 7| 1| 7| 3| 7| 7| 7| 8| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |    3     3                                                               |             
      Valve, Thrombosis                    |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                           3                              |             
      Hematopoietic Cell Proliferation     |                                                                         1|             
      Hyperplasia                          |                2                                                         |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 3                       1           1                             2     1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2     1  1  2                          1           1                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                               3  2           3                       2  2|             
      Pars Distalis, Cyst                  |    3              2     3                             3                  |             
      Pars Distalis, Hyperplasia           |    1     2           2  3  2                    2     3                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      C-Cell, Hyperplasia                  |                   1  1                    1              1  1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               2           1                              |             
      Hyperplasia                          |       1                                                                  |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          4  4  4                       2     1     3                     |             
      Bilateral, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +  +                                +     +           +      |             
      Mediastinal, Congestion              |                                                                          |             
      Pancreatic, Erythrophagocytosis      |    2                                                                     |             
      Renal, Hemorrhage                    |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 0| 0| 3| 1| 3| 3| 2| 9| 3| 3| 3| 2| 2| 7| 1| 3| 8| 3| 2| 3| 3| 3| 6| 3| 0|             
                                           | 6| 2| 7| 9| 7| 4| 7| 8| 7| 7| 7| 5| 9| 6| 6| 7| 1| 7| 3| 7| 7| 7| 8| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          2                                      2                        |             
      Infiltration Cellular, Plasma Cell   |                                  4                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |    2                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           2                              |             
      Fibrosis                             |    1     2                    3                       3              1   |             
      Hematopoietic Cell Proliferation     |    3                                                                    4|             
      Pigmentation                         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Ectopic Parathyroid Gland            |          2                                         1                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    1                                         1                           |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                1        1|             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                      2                                                   |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Inflammation,       |                                                                          |             
          Chronic                          |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                         1|             
      Infiltration Cellular, Histiocyte    |                   2                                   2        1         |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 0| 0| 3| 1| 3| 3| 2| 9| 3| 3| 3| 2| 2| 7| 1| 3| 8| 3| 2| 3| 3| 3| 6| 3| 0|             
                                           | 6| 2| 7| 9| 7| 4| 7| 8| 7| 7| 7| 5| 9| 6| 6| 7| 1| 7| 3| 7| 7| 7| 8| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                1              2                          2               |             
      Capillary, Thrombosis                |          1                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   X                                                      |             
      Fungus                               |                                                                          |             
      Inflammation, Chronic Active         |                   1                                                      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                 2                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        | 2  2     2        2                                                      |             
      Infarct                              |                                                       2                  |             
      Nephropathy, Chronic                 | 2  2  2  2  2  3  2  2  3  2  3  1  2  2  3  2  2  2  2  2  2  2  1  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 4| 7| 6|            |
                             DAY ON TEST   | 5| 3| 2| 3| 6| 7| 3| 4| 3| 3| 5| 3| 7| 3| 0| 3| 6| 2| 9| 0| 9| 2| 9| 3| 2|            |
                                           | 4| 6| 1| 7| 3| 2| 7| 6| 7| 7| 4| 7| 9| 5| 4| 7| 3| 2| 6| 4| 1| 7| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 MG/KG                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 4| 5| 7| 8| 0| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                 2                        |      1  2.0|
      Ulcer                                |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                           1           1                  |      3  1.3|
      Basophilic Focus                     | X  X     X  X     X  X  X  X  X  X     X  X  X  X        X        X  X   |     35     |
      Clear Cell Focus                     |                   X              X                    X                  |      7     |
      Eosinophilic Focus                   |          X        X     X        X     X                                 |     12     |
      Hematopoietic Cell Proliferation     |                            1                                             |      3  1.3|
      Hepatodiaphragmatic Nodule           | X        X  X              X                          X     X            |     11     |
      Inflammation, Granulomatous          |                                                 2                        |      1  2.0|
      Mixed Cell Focus                     |          X                 X     X           X           X        X  X   |     10     |
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                3                    3              2        3           3|     11  2.9|
      Periportal, Vacuolization Cytoplasmic|                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +     +     +           +              +               |   8        |
      Fat, Necrosis                        |                   2           2           3              2               |      6  2.2|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                          +               |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Acinus, Atrophy                      |    2                 1           1           1  1     2  1        1      |     19  1.4|
      Artery, Thrombosis                   |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                               2                                          |      1  2.0|
      Duct, Cyst                           |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |    2           2                    2           2  2  4  2  3            |     13  2.2|
      Inflammation, Chronic                |                2                                3     3  2  3            |      9  2.6|
      Ulcer                                |    1           2                    2           3  1  4     3            |     10  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |       2                             1              2  2     3           2|     13  2.2|
      Mineralization                       |                                                    3                     |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 4| 7| 6|            |
                             DAY ON TEST   | 5| 3| 2| 3| 6| 7| 3| 4| 3| 3| 5| 3| 7| 3| 0| 3| 6| 2| 9| 0| 9| 2| 9| 3| 2|            |
                                           | 4| 6| 1| 7| 3| 2| 7| 6| 7| 7| 4| 7| 9| 5| 4| 7| 3| 2| 6| 4| 1| 7| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 MG/KG                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 4| 5| 7| 8| 0| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    2  1  1  1  1  2  1  2  1  1  1     2  1  1  1  3  2  2  2        2   |     41  1.4|
      Mineralization                       |                                                    1                     |      1  1.0|
      Atrium, Thrombosis                   |                                                                         4|      3  3.3|
      Valve, Thrombosis                    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              2                           |      1  2.0|
      Atrophy                              |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |                   2  1  1        1           1  1                        |      7  1.3|
      Necrosis                             |       3                                                                  |      1  3.0|
      Vacuolization Cytoplasmic            |    2              1        1     1  2        2  2     1                  |     13  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1                             1                                       |      8  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  44        |
      Hyperplasia                          |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           | 2                    2                                      3           3|      9  2.4|
      Pars Distalis, Cyst                  |             2                       3                                    |      6  2.7|
      Pars Distalis, Hyperplasia           | 1           3        1                                                  2|     11  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |                                     1        1        1              2   |      9  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                      2   |      3  1.7|
      Hyperplasia                          | 3                                                                    3   |      3  2.3|
      Inflammation, Acute                  |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          3                                                  2            |      8  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 4| 7| 6|            |
                             DAY ON TEST   | 5| 3| 2| 3| 6| 7| 3| 4| 3| 3| 5| 3| 7| 3| 0| 3| 6| 2| 9| 0| 9| 2| 9| 3| 2|            |
                                           | 4| 6| 1| 7| 3| 2| 7| 6| 7| 7| 4| 7| 9| 5| 4| 7| 3| 2| 6| 4| 1| 7| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 MG/KG                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 4| 5| 7| 8| 0| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Cyst                      |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +        +                    +              +        +            |  13        |
      Mediastinal, Congestion              |                                                    2                     |      1  2.0|
      Pancreatic, Erythrophagocytosis      |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                    2                     |      3  2.0|
      Infiltration Cellular, Plasma Cell   |                                                       3                  |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                 4                        |      1  4.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis                             |                                                    3                     |      6  2.2|
      Hematopoietic Cell Proliferation     |             2                                                            |      3  3.0|
      Pigmentation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Ectopic Parathyroid Gland            |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  I  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Galactocele                          |                            X  X                                          |      2     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      2  1.0|
      Inflammation, Acute                  |                                                       4                  |      1  4.0|
      Inflammation, Chronic                |                               1     3                             1  1   |      6  1.3|
      Ulcer                                |                                     3                                    |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                        2                 2               |      2  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Inflammation,       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 4| 7| 6|            |
                             DAY ON TEST   | 5| 3| 2| 3| 6| 7| 3| 4| 3| 3| 5| 3| 7| 3| 0| 3| 6| 2| 9| 0| 9| 2| 9| 3| 2|            |
                                           | 4| 6| 1| 7| 3| 2| 7| 6| 7| 7| 4| 7| 9| 5| 4| 7| 3| 2| 6| 4| 1| 7| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 MG/KG                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      L     |
                                           | 4| 5| 7| 8| 0| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Chronic                          |                                                 2                        |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                    4  1                  |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                      1                             2                     |      5  1.6|
      Inflammation, Acute                  |                                                    1                     |      1  1.0|
      Inflammation, Chronic                |                                                                          |      3  1.7|
      Capillary, Thrombosis                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |          X                                                               |      2     |
      Fungus                               |          1                                                              2|      2  1.5|
      Inflammation, Chronic Active         |          1                                            1                 2|      4  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                                                          |      4  2.0|
      Infarct                              |                                                                          |      1  2.0|
      Nephropathy, Chronic                 | 1  2  2  1  2  1  3  1  2  2  2  3  3  1     1  1  4  4  3  2  1  2  3  1|     49  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 6| 6| 7| 6| 4| 7| 4| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 2| 8| 6| 3| 1| 9| 8| 3| 8| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3|             
                                           | 7| 9| 2| 7| 7| 5| 4| 2| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    36 MG/KG                               | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
                                           | 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Erosion                              |                      1                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                      1                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             1            |             
      Basophilic Focus                     | X     X  X  X  X  X     X  X     X           X     X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     | X                          X                 X        X                  |             
      Eosinophilic Focus                   | X        X                 X     X           X           X     X  X     X|             
      Hepatodiaphragmatic Nodule           | X           X                          X                                 |             
      Mixed Cell Focus                     | X     X           X                                                      |             
      Regeneration                         |                   3                                                      |             
      Centrilobular, Atrophy               |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                      3                                      2            |             
      Periportal, Vacuolization Cytoplasmic|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                 +        +  +                                 |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |          2                 2        3                                    |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                         +                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1  1  1     1  1     1        1                 2  1              1  1   |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2                                                |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |       3        3     3                       1                           |             
      Inflammation, Chronic                |       3              3                                                   |             
      Ulcer                                |       4        3     2                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       2                                                                  |             
      Ulcer                                |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 6| 6| 7| 6| 4| 7| 4| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 2| 8| 6| 3| 1| 9| 8| 3| 8| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3|             
                                           | 7| 9| 2| 7| 7| 5| 4| 2| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    36 MG/KG                               | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
                                           | 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  3  2  2  1  1  2  2     2  1  2  1  1  2  2  2  2  2  1  2  2  1  2  1|             
      Atrium, Thrombosis                   |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                   2                                         1            |             
      Necrosis                             |    2                                                                     |             
      Vacuolization Cytoplasmic            | 2     1     1  2     2                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Pars          |                                                                          |             
          Intermedia, Hyperplasia          |          2                                                               |             
      Pars Distalis, Angiectasis           |    2     2     2  3        3                    3                        |             
      Pars Distalis, Cyst                  |                                              2                           |             
      Pars Distalis, Hyperplasia           |             2  1  2     2  2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             1        1                                      1     1     1|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             4                                         1                  |             
      Hyperplasia                          |                                                 2                        |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      2   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |             1                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                 +                 +  +                              |             
      Bronchial, Depletion Lymphoid        |                                                                          |             
      Lumbar, Depletion Lymphoid           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 6| 6| 7| 6| 4| 7| 4| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 2| 8| 6| 3| 1| 9| 8| 3| 8| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3|             
                                           | 7| 9| 2| 7| 7| 5| 4| 2| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    36 MG/KG                               | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
                                           | 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Ectasia                 |                      2                                                   |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                         3                                                |             
      Infiltration Cellular, Plasma Cell   |                         4                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      3                          2                        |             
      Hematopoietic Cell Proliferation     |       3                                                                  |             
      Pigmentation                         |                               2                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |       X              X                                   X           X   |             
      Inflammation, Chronic Active         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 1                                                                        |             
      Inflammation, Chronic                | 1                                1  1              1  1     1           1|             
      Skin, Site of Application, Acanthosis|                                                                          |             
      Skin, Site of Application,           |                                                                          |             
          Hyperkeratosis                   |                                                                          |             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic            |                                     1                                    |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                1                                                         |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Inflammation,       |                                                                          |             
          Chronic                          |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Fracture                    |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 6| 6| 7| 6| 4| 7| 4| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 2| 8| 6| 3| 1| 9| 8| 3| 8| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3|             
                                           | 7| 9| 2| 7| 7| 5| 4| 2| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    36 MG/KG                               | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
                                           | 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |             1           1              2                                 |             
      Inflammation, Chronic                |                                                          2               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Edema                      |                                                                          |             
      Serosa, Fibrosis                     |                               1                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                X                                                         |             
      Fungus                               |                2                                                         |             
      Inflammation, Chronic Active         |                2           2                 2                           |             
      Thrombosis                           |                      3                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |       2                                                                  |             
      Nephropathy, Chronic                 | 3  1  3  3  1  2  2  3  1  3     3  1     2  3  2  3  2  3  3  2  3  3  3|             
      Pigmentation                         |       2                                                                  |             
      Papilla, Necrosis                    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 4| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 2| 7|            |
                             DAY ON TEST   | 0| 3| 3| 8| 1| 5| 1| 3| 3| 1| 3| 8| 9| 2| 3| 0| 4| 3| 3| 7| 3| 3| 7| 9| 2|            |
                                           | 8| 8| 7| 8| 4| 4| 9| 7| 7| 3| 6| 8| 2| 4| 6| 5| 7| 4| 6| 2| 6| 6| 3| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    36 MG/KG                               | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|      L     |
                                           | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  47        |
      Erosion                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +|  47        |
      Erosion                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  43        |
      Hemorrhage                           |    2                                                                     |      1  2.0|
      Inflammation, Acute                  |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +  A  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  A  +  +  +  +  +  A  +|  40        |
      Inflammation, Chronic                |          3                                                               |      1  3.0|
      Metaplasia, Osseous                  |          3                                                               |      1  3.0|
      Ulcer                                |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |       X        X  X  X  X  X  X  X     X  X  X     X  X  X  X  X  X     X|     36     |
      Clear Cell Focus                     |                                        X  X           X                  |      7     |
      Eosinophilic Focus                   | X     X              X     X              X           X                 X|     16     |
      Hepatodiaphragmatic Nodule           |    X           X                                                         |      5     |
      Mixed Cell Focus                     |                            X              X                    X         |      6     |
      Regeneration                         |                                                                          |      1  3.0|
      Centrilobular, Atrophy               |                                                 2                        |      1  2.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |    3        3                                            3               |      5  2.8|
      Periportal, Vacuolization Cytoplasmic|                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                        +        +  +     +               |   8        |
      Inflammation, Chronic                |                                                 2                        |      1  2.0|
      Fat, Necrosis                        |                                        2        2  3     2               |      7  2.3|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                         1                             2  1  1            |     15  1.1|
      Duct, Cyst                           |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |    2        2                       3                          2  2     3|     10  2.4|
      Inflammation, Chronic                |                                     2                          2  2     3|      6  2.5|
      Ulcer                                |    4        1                       3                    1        4      |      8  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 4| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 2| 7|            |
                             DAY ON TEST   | 0| 3| 3| 8| 1| 5| 1| 3| 3| 1| 3| 8| 9| 2| 3| 0| 4| 3| 3| 7| 3| 3| 7| 9| 2|            |
                                           | 8| 8| 7| 8| 4| 4| 9| 7| 7| 3| 6| 8| 2| 4| 6| 5| 7| 4| 6| 2| 6| 6| 3| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    36 MG/KG                               | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|      L     |
                                           | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |    2        1     1                          1           1               |      6  1.3|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  2  2  1        2  2  2  1  1  2  1  1  2  1  2  2  2  1  2  2     1  1|     46  1.6|
      Atrium, Thrombosis                   |    2                                                                     |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                    2                     |      1  2.0|
      Hyperplasia                          |                      4                                      4            |      4  2.8|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |    1     2  1                                         2  1  2           1|     12  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  1                 3                     |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Craniopharyngeal Duct, Pars          |                                                                          |            |
          Intermedia, Hyperplasia          |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |    2     3              2  2     3                    2     3            |     13  2.5|
      Pars Distalis, Cyst                  |                                                    3                     |      2  2.5|
      Pars Distalis, Hyperplasia           |                2  2        2  2  2                 1  2              2   |     13  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |       1     2                    1  1     1                       1     1|     12  1.1|
      Follicular Cell, Hyperplasia         |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                                                                          |      2  2.5|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                           2                    2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          4        4                                                      |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 4| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 2| 7|            |
                             DAY ON TEST   | 0| 3| 3| 8| 1| 5| 1| 3| 3| 1| 3| 8| 9| 2| 3| 0| 4| 3| 3| 7| 3| 3| 7| 9| 2|            |
                                           | 8| 8| 7| 8| 4| 4| 9| 7| 7| 3| 6| 8| 2| 4| 6| 5| 7| 4| 6| 2| 6| 6| 3| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    36 MG/KG                               | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|      L     |
                                           | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                 +                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myelofibrosis                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +                       +                 +     +           +   |  10        |
      Bronchial, Depletion Lymphoid        |                                                                      3   |      1  3.0|
      Lumbar, Depletion Lymphoid           |                                                                      3   |      1  3.0|
      Mediastinal, Ectasia                 |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |    2     2                                         4                     |      3  2.7|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                  3                                       |      1  3.0|
      Pancreatic, Ectasia                  |    2                                                                     |      1  2.0|
      Pancreatic, Pigmentation             |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                    3                     |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |          4                                                               |      1  4.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                 2  2                     |      4  2.3|
      Hematopoietic Cell Proliferation     |          3                       3  2           3                        |      5  2.8|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Galactocele                          | X                                X        X        X           X  X      |     10     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  1.0|
      Inflammation, Chronic                |                            1     1                    1                  |     10  1.0|
      Skin, Site of Application, Acanthosis|                                                          1               |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 4| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 2| 7|            |
                             DAY ON TEST   | 0| 3| 3| 8| 1| 5| 1| 3| 3| 1| 3| 8| 9| 2| 3| 0| 4| 3| 3| 7| 3| 3| 7| 9| 2|            |
                                           | 8| 8| 7| 8| 4| 4| 9| 7| 7| 3| 6| 8| 2| 4| 6| 5| 7| 4| 6| 2| 6| 6| 3| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    36 MG/KG                               | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|      L     |
                                           | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Skin, Site of Application,           |                                                                          |            |
          Hyperkeratosis                   |       1                                                                  |      1  1.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic            |                                                                          |      1  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |       2                                                     2            |      3  1.7|
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Fracture                    |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                          1               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                      3   |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                   1  1   |      5  1.2|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |      1  2.0|
      Alveolus, Edema                      |                                                 2                        |      1  2.0|
      Serosa, Fibrosis                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                         X|      2     |
      Fungus                               |                                                             2           2|      3  2.0|
      Inflammation, Chronic Active         |                                              2              2           2|      6  2.0|
      Thrombosis                           |    2                                                     3               |      3  2.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 4| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 2| 7|            |
                             DAY ON TEST   | 0| 3| 3| 8| 1| 5| 1| 3| 3| 1| 3| 8| 9| 2| 3| 0| 4| 3| 3| 7| 3| 3| 7| 9| 2|            |
                                           | 8| 8| 7| 8| 4| 4| 9| 7| 7| 3| 6| 8| 2| 4| 6| 5| 7| 4| 6| 2| 6| 6| 3| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    36 MG/KG                               | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|      L     |
                                           | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy, Chronic                 | 3  2  2     4  1  4  3  2  3  3  3  2  1  3  1  1  2  2     3  3  3     3|     45  2.4|
      Pigmentation                         |          2                                                               |      2  2.0|
      Papilla, Necrosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Transitional Epithelium, Hyperplasia |                                                    2                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 4| 6| 6| 7| 4| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 3| 6| 3| 9| 3| 3| 4| 0| 9| 3| 5| 0| 6| 3| 1| 3| 3| 2| 3| 1| 3|             
                                           | 6| 6| 0| 6| 6| 4| 6| 7| 6| 6| 7| 2| 1| 6| 7| 9| 3| 6| 9| 6| 6| 6| 6| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    60 MG/KG                               | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0|             
                                           | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  A  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  A  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             1            |             
      Basophilic Focus                     | X  X     X  X     X     X  X        X  X  X  X     X     X  X  X     X   |             
      Clear Cell Focus                     |    X              X        X        X                          X         |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   | X  X     X  X     X     X  X           X                       X  X      |             
      Hepatodiaphragmatic Nodule           |                                                    X           X  X      |             
      Mixed Cell Focus                     |    X        X                       X        X                 X         |             
      Regeneration                         |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                       3           2     3|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                       +                       +                  |             
      Inflammation, Chronic                |                                                       1                  |             
      Metaplasia, Osseous                  |                                                                          |             
      Fat, Necrosis                        |       3                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |       1  1           2  1  1                                   1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |          X                                                               |             
      Hyperplasia, Squamous                |                                                       2        2        3|             
      Inflammation, Chronic                |                                                       2        2        3|             
      Ulcer                                |                                                                3        3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                       2                  |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  2  2     1  2  1  2     1  2  1  1           1  2  2  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 4| 6| 6| 7| 4| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 3| 6| 3| 9| 3| 3| 4| 0| 9| 3| 5| 0| 6| 3| 1| 3| 3| 2| 3| 1| 3|             
                                           | 6| 6| 0| 6| 6| 4| 6| 7| 6| 6| 7| 2| 1| 6| 7| 9| 3| 6| 9| 6| 6| 6| 6| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    60 MG/KG                               | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0|             
                                           | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Vacuolization Cytoplasmic            |          1                                                           2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1                             1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Metaplasia, Hepatocyte               |                                        1                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                         1                             3        3         |             
      Pars Distalis, Hyperplasia           |       3     2           1  2  1  3     2              2        3  2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1              1        2                 1              1     1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                            2                                             |             
      Metaplasia, Squamous                 |                                                 2                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          2                                         3  3                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Vagina                                  |                               +                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +                                   +     +|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                               2                                          |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                               3                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |             2                                                            |             
      Hematopoietic Cell Proliferation     |                               3                          3               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 4| 6| 6| 7| 4| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 3| 6| 3| 9| 3| 3| 4| 0| 9| 3| 5| 0| 6| 3| 1| 3| 3| 2| 3| 1| 3|             
                                           | 6| 6| 0| 6| 6| 4| 6| 7| 6| 6| 7| 2| 1| 6| 7| 9| 3| 6| 9| 6| 6| 6| 6| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    60 MG/KG                               | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0|             
                                           | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                      X                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 1                          1                                             |             
      Inflammation, Chronic                | 1  1        1              1                                1            |             
      Necrosis                             |                                                                          |             
      Skin, Site of Application, Acanthosis|       1                                               1                  |             
      Skin, Site of Application,           |                                                                          |             
          Hyperkeratosis                   |             1                                                     1      |             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic            |                                                                          |             
      Subcutaneous Tissue, Foreign Body    |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Inflammation,       |                                                                          |             
          Chronic                          |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            1                                             |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                                                                  |             
      Axon, Degeneration                   |       3                                                                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  3                                       |             
      Edema                                |                                           2                              |             
      Infiltration Cellular, Histiocyte    |                                                                      2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1                       1                                         2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                     3                                    |             
      Inflammation, Chronic Active         |                                     2                                    |             
      Thrombosis                           |                                                       3                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 4| 6| 6| 7| 4| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 3| 6| 3| 9| 3| 3| 4| 0| 9| 3| 5| 0| 6| 3| 1| 3| 3| 2| 3| 1| 3|             
                                           | 6| 6| 0| 6| 6| 4| 6| 7| 6| 6| 7| 2| 1| 6| 7| 9| 3| 6| 9| 6| 6| 6| 6| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    60 MG/KG                               | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0|             
                                           | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +        +            |             
      Iris, Synechia                       |                                                             4            |             
      Lens, Cataract                       |                                                    4        3            |             
      Retina, Atrophy                      |                                                    4                     |             
      Retina, Degeneration                 |                                                             4            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Nephropathy, Chronic                 | 2  2  1  2  3  2  2  2  2  3  2     3  2  1  2  2  1  1  3  3  2  1  3  2|             
      Pigmentation                         |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 7|            |
                             DAY ON TEST   | 3| 6| 3| 3| 9| 6| 3| 3| 0| 5| 8| 3| 3| 2| 3| 9| 3| 9| 9| 9| 3| 8| 5| 0| 3|            |
                                           | 0| 0| 6| 6| 0| 8| 6| 6| 9| 1| 8| 6| 6| 7| 6| 4| 6| 2| 8| 2| 6| 9| 9| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    60 MG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|  42        |
      Edema                                |             2                                                            |      1  2.0|
      Ulcer                                |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         3                                                |      2  2.0|
      Basophilic Focus                     | X  X  X           X  X     X     X  X     X  X     X        X  X  X  X  X|     32     |
      Clear Cell Focus                     |                   X              X  X     X                              |      9     |
      Congestion                           |                                                                      2   |      1  2.0|
      Eosinophilic Focus                   |                      X                    X  X  X  X        X        X   |     17     |
      Hepatodiaphragmatic Nodule           |       X                                X                    X            |      6     |
      Mixed Cell Focus                     |                      X                 X  X                    X         |      9     |
      Regeneration                         |                4              3                                          |      2  3.5|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                        3                 3     2         |      6  2.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   4        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                   1                                                      |      1  1.0|
      Fat, Necrosis                        |                   2                                                      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                           1                              |      1  1.0|
      Acinus, Atrophy                      |             2  1  1              1  1  1  1                 1            |     14  1.1|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Diverticulum                         |                                                                          |      1     |
      Hyperplasia, Squamous                |                         2              3     2                           |      6  2.3|
      Inflammation, Chronic                |                         3              2                                 |      5  2.4|
      Ulcer                                |                         3              2     1                           |      5  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |             2  1              3              1           1               |      6  1.7|
      Hyperplasia                          |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 7|            |
                             DAY ON TEST   | 3| 6| 3| 3| 9| 6| 3| 3| 0| 5| 8| 3| 3| 2| 3| 9| 3| 9| 9| 9| 3| 8| 5| 0| 3|            |
                                           | 0| 0| 6| 6| 0| 8| 6| 6| 9| 1| 8| 6| 6| 7| 6| 4| 6| 2| 8| 2| 6| 9| 9| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    60 MG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       | 2  1  2  2     2  2  2  1  1  1  1  1  1  2  2  2  1  2  1  2  1  1  1  1|     43  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   1                                                      |      2  1.0|
      Vacuolization Cytoplasmic            |    2           1                 1  1           1                 2      |      8  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                               1                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                              2                           |      1  2.0|
      Metaplasia, Hepatocyte               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                4                       2                 2  3            |      7  2.6|
      Pars Distalis, Hyperplasia           |                3  2           4        2                    2           3|     16  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  |          1           1                             1                    1|     11  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |    3                                                                     |      1  3.0|
      Inflammation, Acute                  |    1                                                        2            |      2  1.5|
      Inflammation, Chronic                |                                                                         1|      2  1.5|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                 4           4            |      5  3.2|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                    +                     |   2        |
      Inflammation, Chronic                |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Reticulum Cell          |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +     +              +        +                                 |   7        |
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 7|            |
                             DAY ON TEST   | 3| 6| 3| 3| 9| 6| 3| 3| 0| 5| 8| 3| 3| 2| 3| 9| 3| 9| 9| 9| 3| 8| 5| 0| 3|            |
                                           | 0| 0| 6| 6| 0| 8| 6| 6| 9| 1| 8| 6| 6| 7| 6| 4| 6| 2| 8| 2| 6| 9| 9| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    60 MG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Hemorrhage                    |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |          2                                            3                  |      3  2.3|
      Hematopoietic Cell Proliferation     |                                     3  2        2  3                     |      6  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Galactocele                          |                                                 X                       X|      3     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                   1                       3        1                     |      5  1.4|
      Inflammation, Chronic                |                      1     1                                            1|      8  1.0|
      Necrosis                             |                               4                                          |      1  4.0|
      Skin, Site of Application, Acanthosis| 1           1  1                                   1           1  1  1   |      9  1.0|
      Skin, Site of Application,           |                                                                          |            |
          Hyperkeratosis                   |       1  1        1           1  1                                       |      7  1.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic            |                                                 1                    1   |      2  1.0|
      Subcutaneous Tissue, Foreign Body    |                                           X                              |      1     |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                   2                       2                             1|      3  1.7|
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                         2                                                |      2  1.5|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Axon, Degeneration                   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 7|            |
                             DAY ON TEST   | 3| 6| 3| 3| 9| 6| 3| 3| 0| 5| 8| 3| 3| 2| 3| 9| 3| 9| 9| 9| 3| 8| 5| 0| 3|            |
                                           | 0| 0| 6| 6| 0| 8| 6| 6| 9| 1| 8| 6| 6| 7| 6| 4| 6| 2| 8| 2| 6| 9| 9| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    60 MG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Edema                                |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                         1|      2  1.5|
      Inflammation, Chronic Active         |                                              3                           |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                         X                                               X|      2     |
      Fungus                               |                         2                                                |      2  2.5|
      Inflammation, Chronic Active         |                         2                                               2|      3  2.0|
      Thrombosis                           |             3                                            2               |      3  2.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Iris, Synechia                       |                                                                          |      1  4.0|
      Lens, Cataract                       |                                                                          |      2  3.5|
      Retina, Atrophy                      |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |             2                                                            |      1  2.0|
      Nephropathy, Chronic                 | 3  2  3  2  3     2  3  2  1  1  1  2  1  3  3  3  2  3  1  2  1  2  2  3|     48  2.1|
      Pigmentation                         |                               2                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 7| 5| 6| 6| 7|             
                             DAY ON TEST   | 7| 3| 3| 7| 3| 0| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 3| 8| 3| 5| 2| 8| 4| 8| 3|             
                                           | 9| 6| 6| 5| 6| 8| 6| 6| 6| 2| 8| 6| 6| 6| 6| 6| 6| 4| 6| 5| 2| 3| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    100                                    | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    MG/KG                                  | 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1                                               1                  |             
      Basophilic Focus                     |    X  X  X        X  X     X  X  X  X  X  X  X  X  X     X  X  X  X  X  X|             
      Clear Cell Focus                     |       X              X           X        X  X  X        X               |             
      Eosinophilic Focus                   |    X  X           X     X           X        X                          X|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |       X              X     X     X           X     X     X  X     X      |             
      Inflammation, Chronic                |             1                                   1                        |             
      Mixed Cell Focus                     |             X           X     X  X           X                    X      |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |          2                          2                             3  3   |             
      Midzonal, Vacuolization Cytoplasmic  |                                        2                                 |             
      Serosa, Inflammation, Acute          |                                                                          |             
      Serosa, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Hepatocyte               |                                                                          |             
      Acinus, Atrophy                      |          1  1  1     1     1                    1           1  1     1   |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Cyst                           |                               4                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            1                                             |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                       2           3  3   |             
      Inflammation, Chronic                |                                                                   2  3   |             
      Perforation                          |                                                                          |             
      Ulcer                                |                                                                   4  3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                1                                                  3  2   |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  1  1        2  1  3  2     2  2  1  2  3  1  1  1  1  2  1  1     2|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 7| 5| 6| 6| 7|             
                             DAY ON TEST   | 7| 3| 3| 7| 3| 0| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 3| 8| 3| 5| 2| 8| 4| 8| 3|             
                                           | 9| 6| 6| 5| 6| 8| 6| 6| 6| 2| 8| 6| 6| 6| 6| 6| 6| 4| 6| 5| 2| 3| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    100                                    | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    MG/KG                                  | 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Degeneration                         |                                                                          |             
      Hyperplasia                          |             1                                                        1   |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                               1              1  2                 2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1                                      2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Hepatocyte               |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   3     2              4  3                       3      |             
      Pars Distalis, Cyst                  |                                                       2                  |             
      Pars Distalis, Hyperplasia           |       3                             2     2                       2      |             
      Rathke's Cleft, Cyst                 |                                                       2                  |             
      Rathke's Cleft, Hemorrhage           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 1                        |             
      C-Cell, Hyperplasia                  |                      1  2                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3                                   3                              |             
      Bilateral, Cyst                      |                      4  4                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Cystic                  |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                       +                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 7| 5| 6| 6| 7|             
                             DAY ON TEST   | 7| 3| 3| 7| 3| 0| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 3| 8| 3| 5| 2| 8| 4| 8| 3|             
                                           | 9| 6| 6| 5| 6| 8| 6| 6| 6| 2| 8| 6| 6| 6| 6| 6| 6| 4| 6| 5| 2| 3| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    100                                    | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    MG/KG                                  | 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                          2               |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                               2                 2  2                     |             
      Capsule, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Ectopic Parathyroid Gland            |                                                                      1   |             
      Metaplasia, Osseous                  |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                              X  X                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    1                                                                     |             
      Inflammation, Chronic                |       1                                         1                        |             
      Necrosis, Chronic                    |                                                                          |             
      Skin, Site of Application, Acanthosis| 1     1  1  1  1        1  1  1     1        1                           |             
      Skin, Site of Application,           |                                                                          |             
          Hyperkeratosis                   |                                                                          |             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic            |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1                                                                        |             
      Inflammation, Chronic                |                                                 2     2                  |             
      Inflammation, Granulomatous          |                                                             2            |             
      Alveolar Epithelium, Hyperplasia     |                1                                                     3   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | X                                               X     X                  |             
      Fungus                               |                            2                                1            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1                          2                    2     2     2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 7| 5| 6| 6| 7|             
                             DAY ON TEST   | 7| 3| 3| 7| 3| 0| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 3| 8| 3| 5| 2| 8| 4| 8| 3|             
                                           | 9| 6| 6| 5| 6| 8| 6| 6| 6| 2| 8| 6| 6| 6| 6| 6| 6| 4| 6| 5| 2| 3| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    100                                    | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    MG/KG                                  | 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Lens, Cataract                       |                      2                                                   |             
      Posterior Chamber, Hemorrhage        |                      3                                                   |             
      Retina, Degeneration                 |                      4                                                   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  3  1  3  3  2  1  2  3  3  2  3  2  1  2  2  4  1  4  1  2  2  4  4  2|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 7| 6| 7| 7| 3| 5| 7| 7| 6| 6| 7| 7| 6| 5| 7| 4| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 8| 9| 3| 0| 0| 3| 3| 8| 3| 3| 2| 4| 3| 3| 2| 4| 3| 4| 3| 1| 1| 0| 1|            |
                                           | 6| 1| 8| 8| 6| 2| 4| 6| 6| 1| 6| 6| 7| 4| 6| 6| 6| 0| 6| 8| 6| 0| 4| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    100                                    | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|      L     |
    MG/KG                                  | 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|  45        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  A  A  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  1.0|
      Basophilic Focus                     | X     X  X  X                 X        X  X  X        X     X            |     30     |
      Clear Cell Focus                     | X                                X           X              X        X   |     12     |
      Eosinophilic Focus                   |          X  X                 X           X  X  X     X                  |     14     |
      Hematopoietic Cell Proliferation     | 2                                                                        |      1  2.0|
      Hepatodiaphragmatic Nodule           |       X     X  X                 X     X  X     X                        |     16     |
      Inflammation, Chronic                |                                                                      1   |      3  1.0|
      Mixed Cell Focus                     |       X              X                 X     X              X            |     11     |
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |       2           4                                            1  3     2|      9  2.4|
      Midzonal, Vacuolization Cytoplasmic  |                                                                          |      1  2.0|
      Serosa, Inflammation, Acute          |                                                                         2|      1  2.0|
      Serosa, Necrosis                     |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           +                             +|   3        |
      Fat, Necrosis                        |                                           2                             2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Hepatocyte               |                                                    1                     |      1  1.0|
      Acinus, Atrophy                      |       2              1           1                       2              2|     14  1.2|
      Acinus, Hyperplasia                  |                                                                         1|      1  1.0|
      Duct, Cyst                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |          2        2                                               2     3|      7  2.4|
      Inflammation, Chronic                |          2        2                                                     2|      5  2.2|
      Perforation                          |                                                                         X|      1     |
      Ulcer                                |          2        4                                                     4|      5  3.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |          1        3                                               2     1|      7  1.9|
      Ulcer                                |                   3                                                      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 7| 6| 7| 7| 3| 5| 7| 7| 6| 6| 7| 7| 6| 5| 7| 4| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 8| 9| 3| 0| 0| 3| 3| 8| 3| 3| 2| 4| 3| 3| 2| 4| 3| 4| 3| 1| 1| 0| 1|            |
                                           | 6| 1| 8| 8| 6| 2| 4| 6| 6| 1| 6| 6| 7| 4| 6| 6| 6| 0| 6| 8| 6| 0| 4| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    100                                    | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|      L     |
    MG/KG                                  | 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  1  1  1  2  1        1  1  2  2  2     1  1  1  2  2  2  1  2  2  2  1|     43  1.5|
      Atrium, Thrombosis                   |                   4                                               2      |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                        3                                 |      1  3.0|
      Degeneration                         |                   3                                                      |      1  3.0|
      Hyperplasia                          |          1        1                                   1                  |      5  1.0|
      Necrosis                             | 2                                                                        |      1  2.0|
      Vacuolization Cytoplasmic            | 3                             2           2           2                  |      8  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   2                                                      |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Hepatocyte               |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |       2        4                    2                    2  2     1      |     11  2.5|
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |       2           2              3  2                    2  3     2      |     11  2.3|
      Rathke's Cleft, Cyst                 |                                                                          |      1  2.0|
      Rathke's Cleft, Hemorrhage           |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |                               1                    1                     |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                   3                                               3      |      2  3.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                2  2  3                       3           4               |      7  2.9|
      Bilateral, Cyst                      |                                                                          |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 7| 6| 7| 7| 3| 5| 7| 7| 6| 6| 7| 7| 6| 5| 7| 4| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 8| 9| 3| 0| 0| 3| 3| 8| 3| 3| 2| 4| 3| 3| 2| 4| 3| 4| 3| 1| 1| 0| 1|            |
                                           | 6| 1| 8| 8| 6| 2| 4| 6| 6| 1| 6| 6| 7| 4| 6| 6| 6| 0| 6| 8| 6| 0| 4| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    100                                    | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|      L     |
    MG/KG                                  | 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                   2                                                      |      1  2.0|
      Hyperplasia, Cystic                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Plasma Cell   |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 3                                                                        |      4  2.3|
      Capsule, Necrosis                    |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                         2|      1  2.0|
      Ectopic Parathyroid Gland            |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |             X                                X                    X      |      5     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           | 1                    1                                                   |      3  1.0|
      Inflammation, Chronic                | 1           1        1        1                 2           1            |      8  1.1|
      Necrosis, Chronic                    |                                                          1               |      1  1.0|
      Skin, Site of Application, Acanthosis|       1           1     1  1                 1  1  1     1  1  1     1  1|     22  1.0|
      Skin, Site of Application,           |                                                                          |            |
          Hyperkeratosis                   | 1                                                                        |      1  1.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic            | 1     1                                                                  |      2  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 7| 6| 7| 7| 3| 5| 7| 7| 6| 6| 7| 7| 6| 5| 7| 4| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 8| 9| 3| 0| 0| 3| 3| 8| 3| 3| 2| 4| 3| 3| 2| 4| 3| 4| 3| 1| 1| 0| 1|            |
                                           | 6| 1| 8| 8| 6| 2| 4| 6| 6| 1| 6| 6| 7| 4| 6| 6| 6| 0| 6| 8| 6| 0| 4| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    100                                    | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|      L     |
    MG/KG                                  | 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |                                                 1  1                     |      3  1.0|
      Inflammation, Chronic                | 1                                                                        |      3  1.7|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                       X                  |      4     |
      Fungus                               |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                  3                                       |      1  3.0|
      Inflammation, Chronic Active         |                                                 1     2                  |      7  1.7|
      Thrombosis                           |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +                       +      |   3        |
      Lens, Cataract                       |                                           4                       2      |      3  2.7|
      Posterior Chamber, Hemorrhage        |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                           4                              |      2  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 3  2  2  1  3  2  3  3  1  2  2  3  2  1  3  3  1  1  2  1  2     1  1  4|     49  2.2|
      Pigmentation                         |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 5| 4| 6| 6|             
                             DAY ON TEST   | 0| 2| 2| 2| 3| 1| 1| 5| 5| 5| 5| 6| 6| 7| 1| 2| 3| 2| 2| 0| 6| 6| 3| 7| 0|             
                                           | 9| 2| 9| 7| 1| 6| 0| 2| 7| 0| 6| 2| 3| 9| 3| 1| 7| 0| 9| 7| 8| 4| 5| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Chronic Active         |                                                                      4   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                         1|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  A  +|             
      Diverticulum                         | X                                                                        |             
      Inflammation, Chronic                | 3                                                                        |             
      Metaplasia, Osseous                  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                       1                                   1           1|             
      Basophilic Focus                     |    X        X                          X  X                    X     X   |             
      Clear Cell Focus                     |    X                    X     X           X                              |             
      Congestion                           |                                                                      2   |             
      Degeneration, Cystic                 |                               2        1                                 |             
      Hepatodiaphragmatic Nodule           |       X  X                 X           X                       X         |             
      Inflammation, Chronic                |    1                                                                     |             
      Necrosis                             |                      2     2                                      1      |             
      Centrilobular, Necrosis              |                2                 3                                       |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      | 3                    3  2                    4  3                        |             
      Periportal, Vacuolization Cytoplasmic|                                              3                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +           +                    +        +              +   |             
      Hemorrhage                           |                         3                                            3   |             
      Inflammation, Granulomatous          |          3                                                               |             
      Fat, Necrosis                        |             3                                2        2                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Acinus, Atrophy                      | 1  1  2        2     2     1  2           4  2              2  1  1  1   |             
      Acinus, Hyperplasia                  |                                        1                                 |             
      Artery, Inflammation, Chronic        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |       2  3     3  1  3     3  3     4  2     4           2  3        2  2|             
      Inflammation, Chronic                |          3     2     3     2  2     4        4           2  4            |             
      Inflammation, Chronic Active         |          4                                                               |             
      Mineralization                       |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 5| 4| 6| 6|             
                             DAY ON TEST   | 0| 2| 2| 2| 3| 1| 1| 5| 5| 5| 5| 6| 6| 7| 1| 2| 3| 2| 2| 0| 6| 6| 3| 7| 0|             
                                           | 9| 2| 9| 7| 1| 6| 0| 2| 7| 0| 6| 2| 3| 9| 3| 1| 7| 0| 9| 7| 8| 4| 5| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Perforation                          |          X           X     X                                             |             
      Ulcer                                | 2        4           4     4  2     3        4  4           4           2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              | 2  2        2     2  1           2              2                        |             
      Infiltration Cellular, Lymphocyte    |                         2                                                |             
      Inflammation, Chronic                |          2                 2                 3                           |             
      Metaplasia, Squamous                 |                   2                                                      |             
      Mineralization                       |          1  4  2              3        4                    2        3  3|             
      Ulcer                                |                                  2  4                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  3  2  2     3  1  1  2  2  3  2  1  3  1  2  3  2  2  1  2  2  1  2  2|             
      Mineralization                       |    2        3                          2                    2        1  1|             
      Atrium, Inflammation, Acute          | 3                                                                        |             
      Atrium, Thrombosis                   | X              2                                X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      3   |             
      Hyperplasia                          |                                        1                                 |             
      Necrosis                             |                2                                                         |             
      Vacuolization Cytoplasmic            | 1     1     1                       1                          1         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1  1        2     1        1        1     2     4  1  1        1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                    2     3                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    4        2  3        2           2        2     2        3        4   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                        3           1              2      |             
      Pars Distalis, Cyst                  |                                                             X            |             
      Pars Distalis, Hyperplasia           |                2  1           3           2                 3        3   |             
      Pars Distalis, Pigmentation          |                                                                      2   |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Nervosa, Cyst                   |                                                             X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mediastinum, Necrosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 5| 4| 6| 6|             
                             DAY ON TEST   | 0| 2| 2| 2| 3| 1| 1| 5| 5| 5| 5| 6| 6| 7| 1| 2| 3| 2| 2| 0| 6| 6| 3| 7| 0|             
                                           | 9| 2| 9| 7| 1| 6| 0| 2| 7| 0| 6| 2| 3| 9| 3| 1| 7| 0| 9| 7| 8| 4| 5| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                    +                 +   |             
      Foreign Body                         |                                                                          |             
      Inflammation, Acute                  |                                                                      2   |             
      Inflammation, Chronic Active         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                3                                                         |             
      Inflammation, Acute                  |                   1     3                                                |             
      Inflammation, Chronic                |                                  2  1  2                                 |             
      Inflammation, Granulomatous          |                               2                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |    1                                                                     |             
      Inflammation, Chronic                |       2              2  3  3  1  3  4                       3        3  1|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             1                                                            |             
      Interstitial Cell, Hyperplasia       | 1     2  1  2     1  1  2  2  2  1  2     2     2        1     1         |             
      Seminiferous Tubule, Degeneration    |    4        4  4     3  2     4  4     4        4  4     4  4            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                      4     3                                             |             
      Myelofibrosis                        |             2  3        3        2                                       |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +        +  +        +  +                       +               |             
      Mediastinal, Angiectasis             | 1        3                                                               |             
      Mediastinal, Congestion              |                      2                                                   |             
      Mediastinal, Ectasia                 |                   2                                                      |             
      Mediastinal, Erythrophagocytosis     |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                  3                                       |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Angiectasis              |                                  3                                       |             
      Pancreatic, Congestion               |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Necrosis                 |                                  2                                       |             
      Renal, Ectasia                       |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           2                              |             
      Hyperplasia, Lymphoid                |                   3                                            3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 5| 4| 6| 6|             
                             DAY ON TEST   | 0| 2| 2| 2| 3| 1| 1| 5| 5| 5| 5| 6| 6| 7| 1| 2| 3| 2| 2| 0| 6| 6| 3| 7| 0|             
                                           | 9| 2| 9| 7| 1| 6| 0| 2| 7| 0| 6| 2| 3| 9| 3| 1| 7| 0| 9| 7| 8| 4| 5| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                         3                 3                              |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 4  2                                                                     |             
      Congestion                           |                3                                                         |             
      Depletion Lymphoid                   |                                                                          |             
      Ectasia                              |                   3           3  2                                       |             
      Erythrophagocytosis                  |                                                                          |             
      Hemorrhage                           |                                                             2            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    4        3     2                                3  4              3   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Pigmentation                         |                                              2                           |             
      Red Pulp, Thrombosis                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Galactocele                          | X     X     X        X                                                  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                    1           1         |             
      Inflammation, Acute                  |                   1                                                      |             
      Ulcer                                |          1                                                               |             
      Skin, Site of Application, Acanthosis|                                                       1                  |             
      Skin, Site of Application,           |                                                                          |             
          Hyperkeratosis                   |       1                       1                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |          2                                                               |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Subcutaneous Tissue, Skin, Site of   |                                                                          |             
          Application, Fibrosis            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    1     2  3  3        3           2  2              2  2  3        3  2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   3              1                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 5| 4| 6| 6|             
                             DAY ON TEST   | 0| 2| 2| 2| 3| 1| 1| 5| 5| 5| 5| 6| 6| 7| 1| 2| 3| 2| 2| 0| 6| 6| 3| 7| 0|             
                                           | 9| 2| 9| 7| 1| 6| 0| 2| 7| 0| 6| 2| 3| 9| 3| 1| 7| 0| 9| 7| 8| 4| 5| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    4                     |             
      Hemorrhage                           |                                                    3     3        1      |             
      Infiltration Cellular, Histiocyte    |             2  2           1           3           2                 1   |             
      Inflammation, Chronic                | 1                                      2              3                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |             4                                                        1   |             
      Alveolus, Edema                      |    1        3  1                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          2        1     1              1                       1        2|             
      Fungus                               |       2  2              2  2     3        2                    3  2     2|             
      Inflammation, Chronic Active         | 2     2  2  1     1     2  2  2  2        2           2        2  2     2|             
      Thrombosis                           |                                  X                                       |             
      Ulcer                                |                            3                                             |             
      Vein, Thrombosis                     | 3                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                              |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
      Lens, Cataract                       |                                                       2                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X     X  X           X              X                    X            |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                                                                          |             
      Mineralization                       |                                                                      3   |             
      Nephropathy, Chronic                 | 3  4  4  4  4  4  4  4  4  4  4  4  4  4  4  3  2  3  4  3  4  3  2  4  4|             
      Renal Tubule, Hyperplasia            |    4                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Hemorrhage                           |                   2                                                      |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 3| 6| 6| 4| 4| 4| 6| 5| 7| 7| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 7|            |
                             DAY ON TEST   | 2| 1| 3| 9| 5| 6| 9| 2| 9| 4| 2| 2| 2| 8| 8| 5| 6| 9| 4| 5| 2| 5| 8| 1| 2|            |
                                           | 5| 8| 0| 3| 2| 8| 8| 8| 2| 9| 2| 9| 9| 7| 3| 3| 7| 1| 2| 0| 4| 2| 9| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  42        |
      Dilatation                           |          2                                                               |      1  2.0|
      Inflammation, Acute                  |       4                                            4                     |      2  4.0|
      Necrosis                             |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  40        |
      Diverticulum                         |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2                                                              1      |      6  1.3|
      Basophilic Focus                     | X  X                                                                     |      8     |
      Clear Cell Focus                     |                                                                         X|      5     |
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                                           1                              |      3  1.3|
      Hepatodiaphragmatic Nodule           |    X        X                                                  X         |      8     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Necrosis                             |    1                                                                     |      4  1.5|
      Centrilobular, Necrosis              |       2                                                                  |      3  2.3|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      | 4     3                 2  3              2        3              3      |     12  2.9|
      Periportal, Vacuolization Cytoplasmic|    2     2           2                                                   |      4  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                       +                          +     +            |  10        |
      Hemorrhage                           |                                                                          |      2  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Fat, Necrosis                        |    2                       2                          3                  |      6  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                 4                        |      1  4.0|
      Mineralization                       |                                                    2                     |      1  2.0|
      Acinus, Atrophy                      | 1           1     1     1  1  1        2              1  2     2  1  2   |     25  1.5|
      Acinus, Hyperplasia                  |                                                                         3|      2  2.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 3| 6| 6| 4| 4| 4| 6| 5| 7| 7| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 7|            |
                             DAY ON TEST   | 2| 1| 3| 9| 5| 6| 9| 2| 9| 4| 2| 2| 2| 8| 8| 5| 6| 9| 4| 5| 2| 5| 8| 1| 2|            |
                                           | 5| 8| 0| 3| 2| 8| 8| 8| 2| 9| 2| 9| 9| 7| 3| 3| 7| 1| 2| 0| 4| 2| 9| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                | 1  3  2  3  1  4           3  4        1  3  2     2     1     3     2   |     29  2.5|
      Inflammation, Chronic                |                3           3  3           2  2     2           3     2   |     17  2.7|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  3.0|
      Perforation                          |                            X                                             |      4     |
      Ulcer                                |    1  3     4              4  3           4  2           2     2     3   |     20  3.1|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |       2     2              2  1                                1     2   |     13  1.8|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      3  2.3|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Mineralization                       | 2     2                                2  4     1  3              4      |     15  2.7|
      Ulcer                                |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  3  1  1  1  2  1  1  1  2  2  3  3  2  3  2     3  2     3  1  3  3  3|     47  2.0|
      Mineralization                       |    3                                      2        2              2      |     10  2.0|
      Atrium, Inflammation, Acute          |       3                                                                  |      2  3.0|
      Atrium, Thrombosis                   |       4                                                                  |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           | 1                                                                        |      2  2.0|
      Hyperplasia                          |    2                                                                     |      2  1.5|
      Necrosis                             |                                                                2         |      2  2.0|
      Vacuolization Cytoplasmic            | 1              2                       2  1                              |      9  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2     1     3  1     1     4  1     2  1  1  1  3  1  1     2  3  3      |     28  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                     1                                    |      4  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|  48        |
      Hyperplasia                          |    3  2        3                          2  2     3        3     3     2|     18  2.6|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |    3                                                                     |      4  2.3|
      Pars Distalis, Cyst                  |                                              X              X            |      3     |
      Pars Distalis, Hyperplasia           |                               2  2  3                 3                 1|     11  2.3|
      Pars Distalis, Pigmentation          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 3| 6| 6| 4| 4| 4| 6| 5| 7| 7| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 7|            |
                             DAY ON TEST   | 2| 1| 3| 9| 5| 6| 9| 2| 9| 4| 2| 2| 2| 8| 8| 5| 6| 9| 4| 5| 2| 5| 8| 1| 2|            |
                                           | 5| 8| 0| 3| 2| 8| 8| 8| 2| 9| 2| 9| 9| 7| 3| 3| 7| 1| 2| 0| 4| 2| 9| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Intermedia, Cyst                |                                              X                       X   |      2     |
      Pars Nervosa, Cyst                   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                               1  1     1                                 |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                        +                                 |   1        |
      Mediastinum, Necrosis                |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   | +  +                                         +                    +      |   6        |
      Foreign Body                         |                                              X                           |      1     |
      Inflammation, Acute                  |                                              3                           |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                    2           1  2      |      5  1.8|
      Inflammation, Chronic                |                               2                                          |      4  1.8|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                | 2     2     3     2     3     2  2  2        3     3        2     2     2|     23  2.4|
      Inflammation, Chronic Active         |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                              2                           |      2  1.5|
      Interstitial Cell, Hyperplasia       | 2  2  1  2           1  1     2                    2  1        2  2  1   |     27  1.6|
      Seminiferous Tubule, Degeneration    | 4  4           4                    4     4        4     4     4  4      |     21  3.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypoplasia                           |                                                    2              2      |      4  2.8|
      Myelofibrosis                        |                            3                                             |      5  2.6|
      Necrosis                             |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +     +     +  +              +  +  +           +         |  19        |
      Mediastinal, Angiectasis             |                                                                          |      2  2.0|
      Mediastinal, Congestion              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 3| 6| 6| 4| 4| 4| 6| 5| 7| 7| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 7|            |
                             DAY ON TEST   | 2| 1| 3| 9| 5| 6| 9| 2| 9| 4| 2| 2| 2| 8| 8| 5| 6| 9| 4| 5| 2| 5| 8| 1| 2|            |
                                           | 5| 8| 0| 3| 2| 8| 8| 8| 2| 9| 2| 9| 9| 7| 3| 3| 7| 1| 2| 0| 4| 2| 9| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Ectasia                 |                                                                          |      1  2.0|
      Mediastinal, Erythrophagocytosis     | 2                                                  2                     |      2  2.0|
      Mediastinal, Hemorrhage              |                2                                                         |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |       2                                                                  |      1  2.0|
      Pancreatic, Angiectasis              |                                                                          |      1  3.0|
      Pancreatic, Congestion               |                                                    1                     |      1  1.0|
      Pancreatic, Hemorrhage               |    2  2                                                                  |      2  2.0|
      Pancreatic, Necrosis                 |                                                                          |      1  2.0|
      Renal, Ectasia                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Infiltration Cellular, Plasma Cell   |                3              4                                3         |      5  3.2|
      Necrosis                             |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Depletion Lymphoid                   |                                        4                                 |      1  4.0|
      Ectasia                              |                                  2                             3         |      5  2.6|
      Erythrophagocytosis                  |                                                    2           2         |      2  2.0|
      Hemorrhage                           |                                        2                          2      |      3  2.0|
      Hyperplasia, Lymphoid                |                         3                                                |      1  3.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                            3        2  3     2     3                     |     11  2.9|
      Hematopoietic Cell Proliferation     |       3                                   3                              |      2  3.0|
      Pigmentation                         |    2                                                                     |      2  2.0|
      Red Pulp, Thrombosis                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +|  42        |
      Galactocele                          | X           X        X              X        X     X           X         |     12     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |             1     1              1              1  1  1                 1|      9  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 3| 6| 6| 4| 4| 4| 6| 5| 7| 7| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 7|            |
                             DAY ON TEST   | 2| 1| 3| 9| 5| 6| 9| 2| 9| 4| 2| 2| 2| 8| 8| 5| 6| 9| 4| 5| 2| 5| 8| 1| 2|            |
                                           | 5| 8| 0| 3| 2| 8| 8| 8| 2| 9| 2| 9| 9| 7| 3| 3| 7| 1| 2| 0| 4| 2| 9| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                       1                  |      2  1.0|
      Ulcer                                |                                                                          |      1  1.0|
      Skin, Site of Application, Acanthosis|                                                                          |      1  1.0|
      Skin, Site of Application,           |                                                                          |            |
          Hyperkeratosis                   |                                                                          |      2  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |             1                                                            |      1  1.0|
      Subcutaneous Tissue, Skin, Site of   |                                                                          |            |
          Application, Fibrosis            |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 3  3           2                       1  3     2  3           1  2      |     21  2.3|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                               1                       2                  |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  4.0|
      Hemorrhage                           |    2     1                                3                       2      |      7  2.1|
      Infiltration Cellular, Histiocyte    | 2                                         3        1              2      |     10  1.9|
      Inflammation, Chronic                |                                                                          |      3  2.0|
      Inflammation, Chronic Active         |                               3                                          |      1  3.0|
      Mineralization                       |                                                                          |      2  2.5|
      Alveolus, Edema                      |                                           2                              |      4  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |       1        2           1  1           1  1           1  1  1         |     15  1.2|
      Fungus                               |             2  3     2     3     3        3              3  2     2  2   |     19  2.4|
      Inflammation, Chronic Active         |             2  2     2     2  1  2        2              3  2  3  2  3   |     26  2.0|
      Thrombosis                           |       X                                                                  |      2     |
      Ulcer                                |                                                                3         |      2  3.0|
      Vein, Thrombosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 3| 6| 6| 4| 4| 4| 6| 5| 7| 7| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 7|            |
                             DAY ON TEST   | 2| 1| 3| 9| 5| 6| 9| 2| 9| 4| 2| 2| 2| 8| 8| 5| 6| 9| 4| 5| 2| 5| 8| 1| 2|            |
                                           | 5| 8| 0| 3| 2| 8| 8| 8| 2| 9| 2| 9| 9| 7| 3| 3| 7| 1| 2| 0| 4| 2| 9| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                 +     +                  |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | X  X           X           X     X                 X              X      |     13     |
      Hydronephrosis                       |                            3                                             |      1  3.0|
      Infarct                              |                                              2                           |      1  2.0|
      Mineralization                       |                                        1           2                     |      3  2.0|
      Nephropathy, Chronic                 | 4  4  4  1  4  4  3  2  2  4  3  4  4  4  4  3  4  4  4  3  4  4  4  3  4|     50  3.6|
      Renal Tubule, Hyperplasia            |                                                    4                     |      2  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Calculus Gross Observation           |                                     X                                X   |      2     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                1         |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 5| 6| 6| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 4| 6| 6| 5| 4| 9| 5| 6| 2| 2| 6| 4| 4| 0| 2| 5| 2| 0| 4| 9| 2| 3| 5| 5|             
                                           | 9| 5| 0| 3| 0| 7| 4| 1| 0| 8| 6| 3| 9| 1| 3| 7| 3| 5| 2| 1| 8| 5| 9| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    36 MG/KG                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 4| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Angiectasis                          |                2                                                         |             
      Inflammation, Acute                  |                                                                3         |             
      Necrosis                             |          3                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Erosion                              |                                                    2                     |             
      Inflammation, Acute                  |                               2           2  4     3                     |             
      Necrosis                             |                                              4                           |             
      Ulcer                                |          2                    2                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  A  A  +|             
      Inflammation, Chronic                |                                                    3                     |             
      Ulcer                                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1                 1                    4                           |             
      Basophilic Focus                     |          X                             X                          X  X   |             
      Clear Cell Focus                     |                                                       X                  |             
      Degeneration, Cystic                 |                               2                          1               |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           | X                             X                                          |             
      Hyperplasia                          |                         2                                                |             
      Leukocytosis                         |                                                                          |             
      Mineralization                       |                                     1                                    |             
      Mixed Cell Focus                     |                                                                          |             
      Regeneration                         |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                   3              3           3                 3         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Fat, Necrosis                        |                   2                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Acute                  |             2                                                            |             
      Inflammation, Granulomatous          |                                                                          |             
      Acinus, Atrophy                      |    2        1              1  2  1           2     2  2     1     2     1|             
      Acinus, Hyperplasia                  |       1                                         1                        |             
      Artery, Angiectasis                  |                                                                          |             
      Artery, Mineralization               |          2                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 5| 6| 6| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 4| 6| 6| 5| 4| 9| 5| 6| 2| 2| 6| 4| 4| 0| 2| 5| 2| 0| 4| 9| 2| 3| 5| 5|             
                                           | 9| 5| 0| 3| 0| 7| 4| 1| 0| 8| 6| 3| 9| 1| 3| 7| 3| 5| 2| 1| 8| 5| 9| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    36 MG/KG                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 4| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Squamous                |    3     2  3  3  2  2  2  3     3  3        2  2  2     3  3     2  1   |             
      Inflammation, Chronic                |    2        2  2                 2  2                    3           2   |             
      Mineralization                       |                                                                          |             
      Perforation                          |                                                          X        X      |             
      Ulcer                                |             3  2  3  2     4     3  3        2     4     4  1  4  4  4   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |             2  1  1  1     1                 1     1        2  1         |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       | 3  4  1  4  2  4     3  4     4     3  3        4                 2  3   |             
      Ulcer                                |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                        +                                 |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  2  1  3  3  2  1  3  2  2  2     3  3  3  2  3     2  2  2  1  2  3  2|             
      Mineralization                       | 2        3  2        3  2     2     2           2                 2  4   |             
      Atrium, Thrombosis                   |                      1                                         3         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    2           3                                                         |             
      Hyperplasia                          |       2                                                                  |             
      Hypertrophy                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Vacuolization Cytoplasmic            |    2     1           2              2              1     2        1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1  1  3  1  2  1     1     3  2  1  2  1  2     3        1  2     1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              1                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2        3  2  3     2  3     3     3  4        4        2        3  2  2|             
      Mineralization                       |          1                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   1      |             
      Mineralization                       |          1                                                               |             
      Craniopharyngeal Duct, Hyperplasia   |                                                                          |             
      Craniopharyngeal Duct, Pars Nervosa, |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                              2        1                  |             
      Pars Distalis, Hyperplasia           |       3     4                       1     2  2        1              3  2|             
      Pars Nervosa, Cyst                   | 2                                                                        |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 5| 6| 6| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 4| 6| 6| 5| 4| 9| 5| 6| 2| 2| 6| 4| 4| 0| 2| 5| 2| 0| 4| 9| 2| 3| 5| 5|             
                                           | 9| 5| 0| 3| 0| 7| 4| 1| 0| 8| 6| 3| 9| 1| 3| 7| 3| 5| 2| 1| 8| 5| 9| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    36 MG/KG                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 4| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                        1                                 |             
      C-Cell, Hyperplasia                  |                            1     2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |    3                                                                     |             
                                            __________________________________________________________________________|             
   Penis                                   |          +              +     +  +     +     +  +                        |             
      Inflammation, Acute                  |          2                    4  2     2                                 |             
      Mineralization                       |                         1                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                               1        1                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                | 2  3     2        1  4  3     2  2     1  1     1  1     3  3     1  2  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                      2                                                   |             
      Mineralization                       |                                                 2                    2   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2                                                                        |             
      Interstitial Cell, Hyperplasia       | 2  1        2     1     1        1  2  1  1  2     1  2  2           2  1|             
      Seminiferous Tubule, Degeneration    | 4  4        4     4  4  4     4  4  4  4  4  4  4  4     4           4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +        +  +        +  +  +  +        +     +                     |             
      Mediastinal, Ectasia                 |                               2     2                                    |             
      Mediastinal, Erythrophagocytosis     |                               2              2                           |             
      Mediastinal, Hemorrhage              |                2           2                                             |             
      Pancreatic, Angiectasis              |                2                                                         |             
      Pancreatic, Ectasia                  |       2                                                                  |             
      Pancreatic, Hemorrhage               |       2                                                                  |             
      Pancreatic, Hyperplasia, Lymphoid    |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 5| 6| 6| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 4| 6| 6| 5| 4| 9| 5| 6| 2| 2| 6| 4| 4| 0| 2| 5| 2| 0| 4| 9| 2| 3| 5| 5|             
                                           | 9| 5| 0| 3| 0| 7| 4| 1| 0| 8| 6| 3| 9| 1| 3| 7| 3| 5| 2| 1| 8| 5| 9| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    36 MG/KG                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 4| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                3                                                         |             
      Depletion Lymphoid                   |                                                                          |             
      Ectasia                              |          3                                   4  3                        |             
      Erythrophagocytosis                  |                      2     2                                             |             
      Hemorrhage                           |    2  3           2                    2                                 |             
      Infiltration Cellular, Histiocyte    |             2                                                            |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       2           2  1                       2                 2  3  2   |             
      Hematopoietic Cell Proliferation     |          2     2     3        3     2                                    |             
      Capsule, Necrosis                    |             2                                                            |             
      Lymphoid Follicle, Depletion Cellular|                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|             
      Angiectasis                          |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|             
      Galactocele                          |                         X     X        X                 X               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                1         |             
      Hyperkeratosis                       |                                        1                                 |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                       1                  |             
      Ulcer                                |                                                                          |             
      Skin, Site of Application, Acanthosis|                                           1        2     1               |             
      Skin, Site of Application, Cyst      |                                                                          |             
          Epithelial Inclusion             |                                                                          |             
      Skin, Site of Application,           |                                                                          |             
          Hyperkeratosis                   |       1  1                                                               |             
      Skin, Site of Application,           |                                                                          |             
          Inflammation, Chronic            |                                                    1     1        1      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 3  3  2  4  3  3     3  3     3     3  3        4        2        3  3   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 5| 6| 6| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 4| 6| 6| 5| 4| 9| 5| 6| 2| 2| 6| 4| 4| 0| 2| 5| 2| 0| 4| 9| 2| 3| 5| 5|             
                                           | 9| 5| 0| 3| 0| 7| 4| 1| 0| 8| 6| 3| 9| 1| 3| 7| 3| 5| 2| 1| 8| 5| 9| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    36 MG/KG                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 4| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                       3                  |             
      Hemorrhage                           |    2                 2        2        2  2                              |             
      Infiltration Cellular, Histiocyte    | 1  2     2     2     3  2     2        2        2  3                     |             
      Inflammation, Acute                  |                                                          1               |             
      Mineralization                       | 1  2     1              2     2        2        2                        |             
      Alveolar Epithelium, Hyperplasia     |                                           2                    2         |             
      Alveolus, Edema                      |                               2        2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Foreign Body                         |             X     X  X        X                             X            |             
      Fungus                               |       2     2     2  2  2                             2     2            |             
      Hemorrhage                           |                                                       3                  |             
      Inflammation, Chronic                |                                                       4                  |             
      Inflammation, Chronic Active         |       2     2     2  2  2     1  1     1                    2            |             
      Ulcer                                |             2                    1                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                            +                                             |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Anterior Chamber, Inflammation, Acute|                            3                                             |             
      Choroid, Mineralization              |                                                                          |             
      Cornea, Inflammation, Acute          |                            3                                             |             
      Lens, Cataract                       |                            2                                             |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X        X  X           X  X        X                 X      |             
      Mineralization                       |    3                                                                     |             
      Nephropathy, Chronic                 | 4  4  4  4  4  4  3  4  4  4  4  3  4  4  3  3  4  4  3  4  4  3  4  4  4|             
      Pigmentation                         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 5| 6| 7| 6| 7| 6| 5| 5| 4| 6| 6| 6| 5| 6| 7| 6| 7| 6| 6| 5| 6|            |
                             DAY ON TEST   | 9| 1| 2| 5| 8| 0| 2| 4| 0| 9| 7| 9| 7| 1| 0| 4| 0| 0| 1| 0| 1| 3| 1| 6| 7|            |
                                           | 2| 3| 9| 4| 0| 3| 9| 0| 4| 3| 1| 2| 1| 0| 1| 9| 4| 9| 6| 0| 8| 0| 3| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    36 MG/KG                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Inflammation, Acute                  | 1                                                                        |      2  2.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +|  44        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Acute                  |             3              2           3                                 |      7  2.7|
      Necrosis                             |                                                                          |      1  4.0|
      Ulcer                                |             4                                                            |      3  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                         2                                   2            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  A  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|  37        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       1           3                                                      |      5  2.0|
      Basophilic Focus                     |                                                                          |      4     |
      Clear Cell Focus                     |                   X                                         X            |      3     |
      Degeneration, Cystic                 |             1           1                             2  1               |      6  1.3|
      Eosinophilic Focus                   |                               X                                          |      1     |
      Hepatodiaphragmatic Nodule           |          X           X              X                       X        X   |      7     |
      Hyperplasia                          |                                                                          |      1  2.0|
      Leukocytosis                         |                      1                                                   |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                           X                              |      1     |
      Regeneration                         |                   3                                                      |      1  3.0|
      Centrilobular, Necrosis              |                                              2                           |      1  2.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                        3                       3         |      6  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                 +                                          |   3        |
      Fat, Necrosis                        |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytoplasmic Alteration               |                               1                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                       2                  |      1  2.0|
      Acinus, Atrophy                      |                1     1  2     1  1     2        2  2        1  1         |     21  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 5| 6| 7| 6| 7| 6| 5| 5| 4| 6| 6| 6| 5| 6| 7| 6| 7| 6| 6| 5| 6|            |
                             DAY ON TEST   | 9| 1| 2| 5| 8| 0| 2| 4| 0| 9| 7| 9| 7| 1| 0| 4| 0| 0| 1| 0| 1| 3| 1| 6| 7|            |
                                           | 2| 3| 9| 4| 0| 3| 9| 0| 4| 3| 1| 2| 1| 0| 1| 9| 4| 9| 6| 0| 8| 0| 3| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    36 MG/KG                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinus, Hyperplasia                  |                                     3                                    |      3  1.7|
      Artery, Angiectasis                  |    4                                                                    3|      2  3.5|
      Artery, Mineralization               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                | 1        2     2  2     3  2     1     1  2  2     2  2  2  3  3  3     3|     34  2.3|
      Inflammation, Chronic                |          2              4  3              2                 3  3  2      |     14  2.4|
      Mineralization                       |                                  2                                       |      1  2.0|
      Perforation                          |                         X                 X                    X         |      5     |
      Ulcer                                |                2        4  4     2        3  4        2  3  4  4        4|     25  3.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |          1  2     1  1     2           1  1        1  1  1  1  1        1|     22  1.2|
      Inflammation, Chronic                |          2                                                               |      1  2.0|
      Mineralization                       | 3              3                 3           1                          2|     19  2.9|
      Ulcer                                |                         3                                                |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  1  2  2  2  1  2  1  1  3  1  2  2  3  1  1  1  3  2  1  1  1  2|     48  2.0|
      Mineralization                       | 1                                2           4              1           1|     15  2.2|
      Atrium, Thrombosis                   |             2                                         3  2               |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperplasia                          |                                                                         1|      2  1.5|
      Hypertrophy                          |                                                                   2      |      1  2.0|
      Inflammation, Acute                  |                                                                         2|      1  2.0|
      Vacuolization Cytoplasmic            |                      1     1                          1     1            |     11  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1     1  1  2  2  2     2  3  1  1     1              2     1  3  1     2|     33  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Hyperplasia                          | 2              3                 3        2  2              3           3|     21  2.7|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 5| 6| 7| 6| 7| 6| 5| 5| 4| 6| 6| 6| 5| 6| 7| 6| 7| 6| 6| 5| 6|            |
                             DAY ON TEST   | 9| 1| 2| 5| 8| 0| 2| 4| 0| 9| 7| 9| 7| 1| 0| 4| 0| 0| 1| 0| 1| 3| 1| 6| 7|            |
                                           | 2| 3| 9| 4| 0| 3| 9| 0| 4| 3| 1| 2| 1| 0| 1| 9| 4| 9| 6| 0| 8| 0| 3| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    36 MG/KG                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  1.0|
      Craniopharyngeal Duct, Hyperplasia   |                            1                                             |      1  1.0|
      Craniopharyngeal Duct, Pars Nervosa, |                                                                          |            |
           Hyperplasia                     |                                                                2         |      1  2.0|
      Pars Distalis, Angiectasis           |                      1                                                  2|      2  1.5|
      Pars Distalis, Cyst                  |                               2                       2                  |      4  1.8|
      Pars Distalis, Hyperplasia           | 2                    1     2     1                    1              2   |     14  1.9|
      Pars Nervosa, Cyst                   |                                                                          |      1  2.0|
      Rathke's Cleft, Cyst                 |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |                1  1  1                                   1        1      |      7  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                      2   |      1  2.0|
      Inflammation, Granulomatous          |                                                                   2      |      1  2.0|
      Mineralization                       |                                  1                                       |      1  1.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                            +                          +  +               |  10        |
      Inflammation, Acute                  |                            2                                             |      5  2.4|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                             3            |      1  3.0|
      Hyperplasia                          |                                                             2            |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                              2                           |      1  2.0|
      Inflammation, Chronic                | 2  2     3  1                 2  2     1        3  2           2  2      |     28  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       | 1  2     1                          2           1  1                 1   |     22  1.4|
      Seminiferous Tubule, Degeneration    |    4     4     4     4     4     4           4           4        4      |     25  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 5| 6| 7| 6| 7| 6| 5| 5| 4| 6| 6| 6| 5| 6| 7| 6| 7| 6| 6| 5| 6|            |
                             DAY ON TEST   | 9| 1| 2| 5| 8| 0| 2| 4| 0| 9| 7| 9| 7| 1| 0| 4| 0| 0| 1| 0| 1| 3| 1| 6| 7|            |
                                           | 2| 3| 9| 4| 0| 3| 9| 0| 4| 3| 1| 2| 1| 0| 1| 9| 4| 9| 6| 0| 8| 0| 3| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    36 MG/KG                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                 +                 +        +              +   |  15        |
      Mediastinal, Ectasia                 |                                                                          |      2  2.0|
      Mediastinal, Erythrophagocytosis     |                                                                          |      2  2.0|
      Mediastinal, Hemorrhage              |                                                       3                  |      3  2.3|
      Pancreatic, Angiectasis              |                                                                          |      1  2.0|
      Pancreatic, Ectasia                  |                                                                          |      1  2.0|
      Pancreatic, Hemorrhage               |                                                       1                  |      2  1.5|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erythrophagocytosis                  |                                                             2            |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Depletion Lymphoid                   |                                                                         3|      1  3.0|
      Ectasia                              |                                                                          |      3  3.3|
      Erythrophagocytosis                  |                                                                          |      2  2.0|
      Hemorrhage                           |                                              2                           |      5  2.2|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |          4              3  3                       1  1                  |     12  2.2|
      Hematopoietic Cell Proliferation     |                3     2                                                   |      7  2.4|
      Capsule, Necrosis                    |                                           2                              |      2  2.0|
      Lymphoid Follicle, Depletion Cellular|                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  44        |
      Angiectasis                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +|  42        |
      Galactocele                          |                                                                   X      |      5     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           | 1     1        1                                         1               |      5  1.0|
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                          1     1         |      2  1.0|
      Inflammation, Chronic                |                                                 1                        |      2  1.0|
      Ulcer                                |                                                       3                  |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 5| 6| 7| 6| 7| 6| 5| 5| 4| 6| 6| 6| 5| 6| 7| 6| 7| 6| 6| 5| 6|            |
                             DAY ON TEST   | 9| 1| 2| 5| 8| 0| 2| 4| 0| 9| 7| 9| 7| 1| 0| 4| 0| 0| 1| 0| 1| 3| 1| 6| 7|            |
                                           | 2| 3| 9| 4| 0| 3| 9| 0| 4| 3| 1| 2| 1| 0| 1| 9| 4| 9| 6| 0| 8| 0| 3| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    36 MG/KG                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Skin, Site of Application, Acanthosis|                               1                                          |      4  1.3|
      Skin, Site of Application, Cyst      |                                                                          |            |
          Epithelial Inclusion             |                                                       X                  |      1     |
      Skin, Site of Application,           |                                                                          |            |
          Hyperkeratosis                   |                                                                          |      2  1.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation, Chronic            |                                                                          |      3  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                2        2        3        1  3        2  2  2           3|     24  2.7|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                 3                        |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |          1                          2                 1              1   |      9  1.7|
      Infiltration Cellular, Histiocyte    |    1                                                  2  3               |     13  2.1|
      Inflammation, Acute                  |                                  2                                       |      2  1.5|
      Mineralization                       |                                                                          |      7  1.7|
      Alveolar Epithelium, Hyperplasia     |                                                             2            |      3  2.0|
      Alveolus, Edema                      |                                                          2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                X  X  X        X                    X     X               |     11     |
      Fungus                               |          2  3  3  2  2  3  2  1     1  2  2        2  1  2               |     21  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |          2  2  2  2  2  2  2  1  2  2  2  2        2  1  2               |     24  1.8|
      Ulcer                                |                            2              2                              |      4  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05069-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 19:57:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 5| 6| 7| 6| 7| 6| 5| 5| 4| 6| 6| 6| 5| 6| 7| 6| 7| 6| 6| 5| 6|            |
                             DAY ON TEST   | 9| 1| 2| 5| 8| 0| 2| 4| 0| 9| 7| 9| 7| 1| 0| 4| 0| 0| 1| 0| 1| 3| 1| 6| 7|            |
                                           | 2| 3| 9| 4| 0| 3| 9| 0| 4| 3| 1| 2| 1| 0| 1| 9| 4| 9| 6| 0| 8| 0| 3| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    36 MG/KG                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +           +                                                      |   3        |
      Anterior Chamber, Inflammation, Acute|                                                                          |      1  3.0|
      Choroid, Mineralization              |       2                                                                  |      1  2.0|
      Cornea, Inflammation, Acute          |                                                                          |      1  3.0|
      Lens, Cataract                       |       2           2                                                      |      3  2.0|
      Retina, Degeneration                 |       4           4                                                      |      2  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                              X        X     X            |     10     |
      Mineralization                       |                                              2                           |      2  2.5|
      Nephropathy, Chronic                 | 4  4  4  4  3  4  3  4  4  4  3  4  3  3  4  4  1  2  4  4  4  4  4  3  4|     50  3.7|
      Pigmentation                         |                               3                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  | 1                                                                        |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked