National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1621

TDMS Study 05070-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           VINYL TOLUENE


NTP Experiment-Test: 05070-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:46




       Facility:  Midwest Research Institute

       Chemical CAS #:  25013154

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05070-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 6           10            1                                                  
    Natural Death                                      8            2            7                                                  
    Accidently Killed                                               1            2                                                  
    Dosing Accident                                                              6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           37           34                                                  
  Animals Examined Microscopically                    48           49           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (48)         (1)          (47)                                                
   Gallbladder                                        (38)         (2)          (42)                                                
   Intestine Large, Colon                             (47)         (2)          (46)                                                
   Intestine Large, Rectum                            (47)         (1)          (40)                                                
   Intestine Small                                    (46)         (6)          (47)                                                
   Intestine Small, Duodenum                          (45)         (3)          (44)                                                
      Polyp Adenomatous                                             1 (33%)                                                         
   Liver                                              (48)         (16)         (49)                                                
      Hemangiosarcoma                                               1 (6%)                                                          
      Hemangiosarcoma, Metastatic, Spleen                           1 (6%)                                                          
      Hepatocellular Carcinoma                         6 (13%)      2 (13%)                                                         
      Hepatocellular Carcinoma, Multiple                            1 (6%)                                                          
      Hepatocellular Adenoma                           4 (8%)       2 (13%)      2 (4%)                                             
   Mesentery                                          (8)          (3)          (2)                                                 
      Plasma Cell Tumor Malignant                                                1 (50%)                                            
   Pancreas                                           (47)         (3)          (49)                                                
   Salivary Glands                                    (48)         (1)          (48)                                                
      Plasma Cell Tumor Malignant                                                1 (2%)                                             
   Stomach, Forestomach                               (47)         (3)          (45)                                                
   Stomach, Glandular                                 (47)         (3)          (47)                                                
      Hamartoma                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (48)         (2)          (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05070-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (47)         (3)          (49)                                                
   Adrenal Gland, Cortex                              (47)         (2)          (48)                                                
   Adrenal Gland, Medulla                             (45)         (2)          (47)                                                
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (47)         (3)          (49)                                                
      Carcinoma                                                     1 (33%)                                                         
   Parathyroid Gland                                  (29)         (1)          (25)                                                
   Pituitary Gland                                    (46)         (5)          (47)                                                
      Pars Distalis, Adenoma                           8 (17%)      3 (60%)      2 (4%)                                             
      Pars Intermedia, Adenoma                         1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (48)         (2)          (42)                                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (46)         (14)         (44)                                                
      Adenoma                                                       1 (7%)                                                          
      Granulosa Cell Tumor Malignant                   1 (2%)                                                                       
      Hemangioma                                       1 (2%)                                                                       
      Plasma Cell Tumor Malignant                                                1 (2%)                                             
   Uterus                                             (48)         (37)         (45)                                                
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Uterus                                      1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                           1 (3%)                                                          
      Plasma Cell Tumor Malignant                                                1 (2%)                                             
      Polyp Stromal                                    2 (4%)       1 (3%)                                                          
      Sarcoma Stromal                                               1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (47)         (2)          (47)                                                
   Lymph Node                                         (48)         (8)          (49)                                                
   Lymph Node, Mandibular                             (45)         (1)          (43)                                                
      Plasma Cell Tumor Malignant                                                1 (2%)                                             
   Lymph Node, Mesenteric                             (38)         (6)          (32)                                                
   Spleen                                             (47)         (13)         (49)                                                
      Hemangiosarcoma                                               3 (23%)                                                         
   Thymus                                             (40)         (2)          (42)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05070-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (1)          (44)                                                
      Adenocarcinoma                                   2 (4%)                                                                       
   Skin                                               (46)         (20)         (47)                                                
      Subcutaneous Tissue, Fibrosarcoma                             2 (10%)                                                         
      Subcutaneous Tissue, Hemangioma                               1 (5%)                                                          
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (40)         (1)          (40)                                                
      Plasma Cell Tumor Malignant                                                1 (3%)                                             
   Lung                                               (48)         (49)         (49)                                                
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     2 (4%)       2 (4%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    2 (4%)                                             
      Hepatocellular Carcinoma, Metastatic                          1 (2%)                                                          
      Pleura, Mediastinum, Plasma Cell Tumor                                                                                        
          Malignant                                                              1 (2%)                                             
   Trachea                                            (48)         (2)          (47)                                                
      Plasma Cell Tumor Malignant                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                       (1)                                                 
      Adenoma, Papillary                               1 (100%)                                                                     
      Carcinoma                                                                  1 (100%)                                           
   Lacrimal Gland                                     (10)                      (5)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05070-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (48)         (7)          (49)                                                
      Hemangiosarcoma, Metastatic, Spleen                           1 (14%)                                                         
   Urinary Bladder                                    (45)         (2)          (40)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(48)        *(49)        *(50)                                                
      Lymphoma Malignant Histiocytic                   3 (6%)       2 (4%)       2 (4%)                                             
      Lymphoma Malignant Lymphocytic                   7 (15%)                   4 (8%)                                             
      Lymphoma Malignant Mixed                         4 (8%)       5 (10%)      1 (2%)                                             
      Lymphoma Malignant Undifferentiated Cell         2 (4%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05070-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            29          27          17                                                   
     Total Primary Neoplasms                           48          31          27                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 16          11           7                                                   
     Total Benign Neoplasms                            22          11           7                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          18          12                                                   
     Total Malignant Neoplasms                         26          20          20                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2                                                               
     Total Metastatic Neoplasm                          2           4                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05070-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           13            4                                                  
    Natural Death                                      6            7            2                                                  
    Accidently Killed                                  1                         1                                                  
    Dosing Accident                                                              2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           30           41                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (9)          (48)                                                
   Intestine Large, Cecum                             (46)         (7)          (44)                                                
   Intestine Large, Colon                             (48)         (10)         (47)                                                
      Serosa, Sarcoma, Metastatic, Uncertain                                                                                        
          Primary Site                                                           1 (2%)                                             
   Intestine Small, Duodenum                          (47)         (10)         (49)                                                
      Polyp Adenomatous                                             1 (10%)      1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (10)         (44)                                                
      Adenocarcinoma                                                1 (10%)                                                         
   Liver                                              (50)         (23)         (48)                                                
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatocellular Carcinoma                         9 (18%)     11 (48%)      7 (15%)                                            
      Hepatocellular Carcinoma, Multiple               1 (2%)       1 (4%)       5 (10%)                                            
      Hepatocellular Adenoma                           6 (12%)      2 (9%)       2 (4%)                                             
      Hepatocellular Adenoma, Multiple                 2 (4%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Mesentery                                          (6)                       (3)                                                 
      Fat, Hemangiosarcoma                                                       1 (33%)                                            
   Pancreas                                           (49)         (9)          (49)                                                
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Salivary Glands                                    (50)         (11)         (50)                                                
   Stomach, Forestomach                               (48)         (10)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05070-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (10)         (48)                                                
      Capsule, Adenoma, Multiple                       1 (2%)                                                                       
      Capsule, Sarcoma, Metastatic, Uncertain                                                                                       
          Primary Site                                                           1 (2%)                                             
   Adrenal Gland, Cortex                              (49)         (10)         (48)                                                
      Adenoma                                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (49)         (9)          (47)                                                
      Pheochromocytoma Benign                          1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (49)         (9)          (49)                                                
      Adenoma                                                                    2 (4%)                                             
   Parathyroid Gland                                  (36)         (6)          (35)                                                
   Pituitary Gland                                    (45)         (11)         (47)                                                
      Pars Distalis, Adenoma                           1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (49)         (9)          (47)                                                
      Follicular Cell, Adenocarcinoma                  1 (2%)                                                                       
      Follicular Cell, Adenoma                         3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (11)         (49)                                                
   Prostate                                           (46)         (9)          (44)                                                
      Serosa, Sarcoma, Metastatic, Uncertain                                                                                        
          Primary Site                                                           1 (2%)                                             
   Seminal Vesicle                                    (48)         (17)         (49)                                                
      Serosa, Sarcoma, Metastatic, Uncertain                                                                                        
          Primary Site                                                           1 (2%)                                             
   Testes                                             (50)         (12)         (49)                                                
      Interstitial Cell, Adenoma                                    1 (8%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (10)         (49)                                                
   Lymph Node                                         (50)         (26)         (50)                                                
   Lymph Node, Mandibular                             (47)         (11)         (35)                                                
   Lymph Node, Mesenteric                             (42)         (19)         (33)                                                
   Spleen                                             (49)         (14)         (49)                                                
      Hemangiosarcoma                                               1 (7%)                                                          
      Capsule, Sarcoma, Metastatic, Uncertain                                                                                       
          Primary Site                                                           1 (2%)                                             
                                                             Page   8                                                               
NTP Experiment-Test: 05070-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (35)         (6)          (34)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (30)         (49)                                                
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (3%)                                                          
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)         (50)                                                
      Osteoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (50)                                                
      Meninges, Hamartoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (44)         (6)          (46)                                                
   Lung                                               (50)         (49)         (49)                                                
      Alveolar/Bronchiolar Adenoma                     9 (18%)      2 (4%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       2 (4%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple         2 (4%)       1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       4 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)                                                              
      Bilateral, Adenoma                                            1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (11)         (50)                                                
   Urinary Bladder                                    (49)         (27)         (47)                                                
                                                             Page   9                                                               
NTP Experiment-Test: 05070-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                   2 (4%)       2 (4%)                                                          
      Lymphoma Malignant Lymphocytic                   3 (6%)                                                                       
      Lymphoma Malignant Mixed                         2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05070-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            33          23          20                                                   
     Total Primary Neoplasms                           48          28          25                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 21           7          10                                                   
     Total Benign Neoplasms                            26           7          11                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          16          13                                                   
     Total Malignant Neoplasms                         22          21          14                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           4           1                                                   
     Total Metastatic Neoplasm                          3           4           7                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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