TDMS Study 05070-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
VINYL TOLUENE
NTP Experiment-Test: 05070-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46
Facility: Midwest Research Institute
Chemical CAS #: 25013154
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund Sacrifice 6 10 1
Natural Death 8 2 7
Accidently Killed 1 2
Dosing Accident 6
Survivors
Terminal Sacrifice 36 37 34
Animals Examined Microscopically 48 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (48) (1) (47)
Gallbladder (38) (2) (42)
Intestine Large, Colon (47) (2) (46)
Intestine Large, Rectum (47) (1) (40)
Intestine Small (46) (6) (47)
Intestine Small, Duodenum (45) (3) (44)
Polyp Adenomatous 1 (33%)
Liver (48) (16) (49)
Hemangiosarcoma 1 (6%)
Hemangiosarcoma, Metastatic, Spleen 1 (6%)
Hepatocellular Carcinoma 6 (13%) 2 (13%)
Hepatocellular Carcinoma, Multiple 1 (6%)
Hepatocellular Adenoma 4 (8%) 2 (13%) 2 (4%)
Mesentery (8) (3) (2)
Plasma Cell Tumor Malignant 1 (50%)
Pancreas (47) (3) (49)
Salivary Glands (48) (1) (48)
Plasma Cell Tumor Malignant 1 (2%)
Stomach, Forestomach (47) (3) (45)
Stomach, Glandular (47) (3) (47)
Hamartoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (48) (2) (48)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (47) (3) (49)
Adrenal Gland, Cortex (47) (2) (48)
Adrenal Gland, Medulla (45) (2) (47)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (47) (3) (49)
Carcinoma 1 (33%)
Parathyroid Gland (29) (1) (25)
Pituitary Gland (46) (5) (47)
Pars Distalis, Adenoma 8 (17%) 3 (60%) 2 (4%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (48) (2) (42)
Follicular Cell, Adenoma 1 (2%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (46) (14) (44)
Adenoma 1 (7%)
Granulosa Cell Tumor Malignant 1 (2%)
Hemangioma 1 (2%)
Plasma Cell Tumor Malignant 1 (2%)
Uterus (48) (37) (45)
Granulosa Cell Tumor Malignant, Metastatic,
Uterus 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (3%)
Plasma Cell Tumor Malignant 1 (2%)
Polyp Stromal 2 (4%) 1 (3%)
Sarcoma Stromal 1 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (47) (2) (47)
Lymph Node (48) (8) (49)
Lymph Node, Mandibular (45) (1) (43)
Plasma Cell Tumor Malignant 1 (2%)
Lymph Node, Mesenteric (38) (6) (32)
Spleen (47) (13) (49)
Hemangiosarcoma 3 (23%)
Thymus (40) (2) (42)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (1) (44)
Adenocarcinoma 2 (4%)
Skin (46) (20) (47)
Subcutaneous Tissue, Fibrosarcoma 2 (10%)
Subcutaneous Tissue, Hemangioma 1 (5%)
Subcutaneous Tissue, Sarcoma 1 (2%)
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MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (40) (1) (40)
Plasma Cell Tumor Malignant 1 (3%)
Lung (48) (49) (49)
Adenocarcinoma, Metastatic, Mammary Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%)
Hepatocellular Carcinoma, Metastatic 1 (2%)
Pleura, Mediastinum, Plasma Cell Tumor
Malignant 1 (2%)
Trachea (48) (2) (47)
Plasma Cell Tumor Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (1)
Adenoma, Papillary 1 (100%)
Carcinoma 1 (100%)
Lacrimal Gland (10) (5)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (48) (7) (49)
Hemangiosarcoma, Metastatic, Spleen 1 (14%)
Urinary Bladder (45) (2) (40)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(48) *(49) *(50)
Lymphoma Malignant Histiocytic 3 (6%) 2 (4%) 2 (4%)
Lymphoma Malignant Lymphocytic 7 (15%) 4 (8%)
Lymphoma Malignant Mixed 4 (8%) 5 (10%) 1 (2%)
Lymphoma Malignant Undifferentiated Cell 2 (4%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 29 27 17
Total Primary Neoplasms 48 31 27
Total Animals with Benign Neoplasms 16 11 7
Total Benign Neoplasms 22 11 7
Total Animals with Malignant Neoplasms 22 18 12
Total Malignant Neoplasms 26 20 20
Total Animals with Metastatic Neoplasms 2 2
Total Metastatic Neoplasm 2 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund Sacrifice 10 13 4
Natural Death 6 7 2
Accidently Killed 1 1
Dosing Accident 2
Survivors
Terminal Sacrifice 33 30 41
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (9) (48)
Intestine Large, Cecum (46) (7) (44)
Intestine Large, Colon (48) (10) (47)
Serosa, Sarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Intestine Small, Duodenum (47) (10) (49)
Polyp Adenomatous 1 (10%) 1 (2%)
Intestine Small, Jejunum (46) (10) (44)
Adenocarcinoma 1 (10%)
Liver (50) (23) (48)
Hemangiosarcoma, Multiple 1 (2%)
Hepatocellular Carcinoma 9 (18%) 11 (48%) 7 (15%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (4%) 5 (10%)
Hepatocellular Adenoma 6 (12%) 2 (9%) 2 (4%)
Hepatocellular Adenoma, Multiple 2 (4%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Mesentery (6) (3)
Fat, Hemangiosarcoma 1 (33%)
Pancreas (49) (9) (49)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Salivary Glands (50) (11) (50)
Stomach, Forestomach (48) (10) (47)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (10) (48)
Capsule, Adenoma, Multiple 1 (2%)
Capsule, Sarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Adrenal Gland, Cortex (49) (10) (48)
Adenoma 1 (2%)
Adrenal Gland, Medulla (49) (9) (47)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (49) (9) (49)
Adenoma 2 (4%)
Parathyroid Gland (36) (6) (35)
Pituitary Gland (45) (11) (47)
Pars Distalis, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (49) (9) (47)
Follicular Cell, Adenocarcinoma 1 (2%)
Follicular Cell, Adenoma 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (11) (49)
Prostate (46) (9) (44)
Serosa, Sarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Seminal Vesicle (48) (17) (49)
Serosa, Sarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Testes (50) (12) (49)
Interstitial Cell, Adenoma 1 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (10) (49)
Lymph Node (50) (26) (50)
Lymph Node, Mandibular (47) (11) (35)
Lymph Node, Mesenteric (42) (19) (33)
Spleen (49) (14) (49)
Hemangiosarcoma 1 (7%)
Capsule, Sarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Page 8
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymus (35) (6) (34)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (30) (49)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (3%)
Subcutaneous Tissue, Hemangioma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (10) (50)
Osteoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (11) (50)
Meninges, Hamartoma 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (44) (6) (46)
Lung (50) (49) (49)
Alveolar/Bronchiolar Adenoma 9 (18%) 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma, Multiple 2 (4%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 3 (6%) 4 (8%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Bilateral, Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (11) (50)
Urinary Bladder (49) (27) (47)
Page 9
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 2 (4%) 2 (4%)
Lymphoma Malignant Lymphocytic 3 (6%)
Lymphoma Malignant Mixed 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 33 23 20
Total Primary Neoplasms 48 28 25
Total Animals with Benign Neoplasms 21 7 10
Total Benign Neoplasms 26 7 11
Total Animals with Malignant Neoplasms 18 16 13
Total Malignant Neoplasms 22 21 14
Total Animals with Metastatic Neoplasms 3 4 1
Total Metastatic Neoplasm 3 4 7
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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