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TDMS Study 05070-02 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Midwest Research Inst                                    VINYL TOLUENE                                    DATE: 09/09/94       
EXPERIMENT: 05070 TEST: 02                                                                                     TIME: 00:18:26       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-38042          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 56406        
PATHOLOGIST: M. STEDHAM                                                                                        CAS: 25013154        
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Midwest Research Inst                                    VINYL TOLUENE                                    DATE: 09/09/94      
EXPERIMENT: 05070 TEST: 02                                                                                     TIME: 00:18:26      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-38042          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 56406       
PATHOLOGIST: M. STEDHAM                                                                                        CAS: 25013154       
 
 
 
 
 
                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Midwest Research Inst                                    VINYL TOLUENE                                    DATE: 09/09/94       
EXPERIMENT: 05070 TEST: 02                                                                                     TIME: 00:18:26       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-38042          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 56406        
PATHOLOGIST: M. STEDHAM                                                                                        CAS: 25013154        
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                         IN THE ANALYSIS OF THE STUDY OF VINYL TOLUENE
 
              ====================================================================================================
 
                                                           MALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Lung                          Alveolar/Bronchiolar Adenoma
                                                           Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
                             Thyroid Gland: Follicular Cell
                                                           Carcinoma or Adenoma
                             All Organs                    Malignant Lymphoma And Histiocytic Sarcoma
                                                           Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
                                                            NOS, or Undifferentiated Cell Type
                                                           Benign Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
 
                                                           FEMALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Islets, Pancreatic            Carcinoma or Adenoma
                             Liver                         Hepatocellular Carcinoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                             Spleen                        Hemangiosarcoma
                             All Organs                    Malignant Lymphoma And Histiocytic Sarcoma
                                                           Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
                                                            NOS, or Undifferentiated Cell Type
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE   1
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         10 PPM          25 PPM        |      CONTROL         10 PPM          25 PPM        |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/49 (0%)       0/9 (0%)        2/49 (4%)      |     0/47 (0%)       0/3 (0%)        0/49 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            4.9%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/33 (0%)       0/0             2/41 (5%)      |     0/36 (0%)       0/1 (0%)        0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             731 (T)       |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.198           (e)           P=0.287        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.198           (e)           P=0.287        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.198           (e)           P=0.287        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.143                                        |       (e)                                          |
|FISHER EXACT           |                       (e)           P=0.247        |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/49 (0%)       0/9 (0%)        2/49 (4%)      |     0/47 (0%)       1/3 (33%)       0/49 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            4.9%          |      0.0%          100.0%            0.0%          |
|TERMINAL (d)           |     0/33 (0%)       0/0             2/41 (5%)      |     0/36 (0%)       1/1 (100%)      0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             731 (T)       |      ---             731 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.198           (e)           P=0.287        |     P=0.668N        P=0.002 **        (e)          |
|INCIDENTAL TUMOR       |     P=0.198           (e)           P=0.287        |     P=0.668N        P=0.002 **        (e)          |
|LOGISTIC REGRESSION    |     P=0.198           (e)           P=0.287        |     P=0.668N        P=0.002 **        (e)          |
|COCHRAN-ARMITAGE       |     P=0.143                                        |     P=0.653N                                       |
|FISHER EXACT           |                       (e)           P=0.247        |                     P=0.060           (e)          |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE   2
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         10 PPM          25 PPM        |      CONTROL         10 PPM          25 PPM        |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     8/50 (16%)      2/23 (9%)       2/48 (4%)      |     4/48 (8%)       2/16 (13%)      2/49 (4%)      |
|ADJUSTED (b)           |     22.9%           25.0%            4.9%          |     10.5%           28.6%            4.9%          |
|TERMINAL (d)           |     7/33 (21%)      2/8 (25%)       2/41 (5%)      |     3/36 (8%)       2/7 (29%)       1/34 (3%)      |
|FIRST INCIDENCE (DAYS) |      588             731 (T)         731 (T)       |      692             731 (T)          42           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.016N*       P=0.590N        P=0.023N*      |     P=0.299N        P=0.418         P=0.371N       |
|INCIDENTAL TUMOR       |     P=0.018N*       P=0.518N        P=0.039N*      |     P=0.172N        P=0.407         P=0.237N       |
|LOGISTIC REGRESSION    |     P=0.028N*       P=0.541N        P=0.046N*      |     P=0.203N        P=0.385         P=0.233N       |
|COCHRAN-ARMITAGE       |     P=0.041N*                                      |     P=0.258N                                       |
|FISHER EXACT           |                     P=0.328N        P=0.053N       |                     P=0.471         P=0.329N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    10/50 (20%)     12/23 (52%)     12/48 (25%)     |     6/48 (13%)      3/16 (19%)      0/49 (0%)      |
|ADJUSTED (b)           |     23.5%           59.1%           27.8%          |     15.5%           18.3%            0.0%          |
|TERMINAL (d)           |     4/33 (12%)      4/8 (50%)      10/41 (24%)     |     4/36 (11%)      1/7 (14%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      514             434             702           |      692             679             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.452N        P=0.068         P=0.575        |     P=0.022N*       P=0.594         P=0.025N*      |
|INCIDENTAL TUMOR       |     P=0.116         P=0.034 *       P=0.110        |     P=0.031N*       P=0.561         P=0.035N*      |
|LOGISTIC REGRESSION    |     P=0.123         P=0.015 *       P=0.363        |     P=0.025N*       P=0.362         P=0.026N*      |
|COCHRAN-ARMITAGE       |     P=0.424                                        |     P=0.015N*                                      |
|FISHER EXACT           |                     P=0.007 **      P=0.363        |                     P=0.399         P=0.012N*      |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE   3
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         10 PPM          25 PPM        |      CONTROL         10 PPM          25 PPM        |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    17/50 (34%)     14/23 (61%)     14/48 (29%)     |     9/48 (19%)      5/16 (31%)      2/49 (4%)      |
|ADJUSTED (b)           |     41.9%           79.6%           32.5%          |     23.4%           45.5%            4.9%          |
|TERMINAL (d)           |    11/33 (33%)      6/8 (75%)      12/41 (29%)     |     7/36 (19%)      3/7 (43%)       1/34 (3%)      |
|FIRST INCIDENCE (DAYS) |      514             434             702           |      692             679              42           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.099N        P=0.065         P=0.163N       |     P=0.033N*       P=0.269         P=0.039N*      |
|INCIDENTAL TUMOR       |     P=0.480N        P=0.037 *       P=0.560N       |     P=0.019N*       P=0.230         P=0.020N*      |
|LOGISTIC REGRESSION    |     P=0.280N        P=0.028 *       P=0.376N       |     P=0.021N*       P=0.143         P=0.021N*      |
|COCHRAN-ARMITAGE       |     P=0.284N                                       |     P=0.020N*                                      |
|FISHER EXACT           |                     P=0.029 *       P=0.384N       |                     P=0.238         P=0.023N*      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    17/50 (34%)     14/23 (61%)     14/48 (29%)     |     9/48 (19%)      5/16 (31%)      2/49 (4%)      |
|ADJUSTED (b)           |     41.9%           79.6%           32.5%          |     23.4%           45.5%            4.9%          |
|TERMINAL (d)           |    11/33 (33%)      6/8 (75%)      12/41 (29%)     |     7/36 (19%)      3/7 (43%)       1/34 (3%)      |
|FIRST INCIDENCE (DAYS) |      514             434             702           |      692             679              42           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.099N        P=0.065         P=0.163N       |     P=0.033N*       P=0.269         P=0.039N*      |
|INCIDENTAL TUMOR       |     P=0.480N        P=0.037 *       P=0.560N       |     P=0.019N*       P=0.230         P=0.020N*      |
|LOGISTIC REGRESSION    |     P=0.280N        P=0.028 *       P=0.376N       |     P=0.021N*       P=0.143         P=0.021N*      |
|COCHRAN-ARMITAGE       |     P=0.284N                                       |     P=0.020N*                                      |
|FISHER EXACT           |                     P=0.029 *       P=0.384N       |                     P=0.238         P=0.023N*      |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE   4
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         10 PPM          25 PPM        |      CONTROL         10 PPM          25 PPM        |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     9/50 (18%)      2/49 (4%)       2/49 (4%)      |     2/48 (4%)       2/49 (4%)       2/49 (4%)      |
|ADJUSTED (b)           |     24.8%            6.7%            4.9%          |      5.6%            5.4%            5.9%          |
|TERMINAL (d)           |     6/33 (18%)      2/30 (7%)       2/41 (5%)      |     2/36 (6%)       2/37 (5%)       2/34 (6%)      |
|FIRST INCIDENCE (DAYS) |      687             731 (T)         731 (T)       |      731 (T)         731 (T)         731 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.009N**      P=0.043N*       P=0.013N*      |     P=0.596         P=0.685N        P=0.675        |
|INCIDENTAL TUMOR       |     P=0.016N*       P=0.045N*       P=0.028N*      |     P=0.596         P=0.685N        P=0.675        |
|LOGISTIC REGRESSION    |     P=0.011N*       P=0.037N*       P=0.018N*      |     P=0.596         P=0.685N        P=0.675        |
|COCHRAN-ARMITAGE       |     P=0.019N*                                      |     P=0.612N                                       |
|FISHER EXACT           |                     P=0.028N*       P=0.028N*      |                     P=0.684N        P=0.684N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       3/49 (6%)       0/49 (0%)      |     1/48 (2%)       0/49 (0%)       2/49 (4%)      |
|ADJUSTED (b)           |      8.6%            8.5%            0.0%          |      2.6%            0.0%            5.3%          |
|TERMINAL (d)           |     2/33 (6%)       2/30 (7%)       0/41 (0%)      |     0/36 (0%)       0/37 (0%)       1/34 (3%)      |
|FIRST INCIDENCE (DAYS) |      696             358             ---           |      714             ---             464           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.072N        P=0.622         P=0.090N       |     P=0.305         P=0.500N        P=0.463        |
|INCIDENTAL TUMOR       |     P=0.059N        P=0.614         P=0.132N       |     P=0.270         P=0.455N        P=0.416        |
|LOGISTIC REGRESSION    |     P=0.091N        P=0.662N        P=0.111N       |     P=0.392         P=0.496N        P=0.541        |
|COCHRAN-ARMITAGE       |     P=0.097N                                       |     P=0.340                                        |
|FISHER EXACT           |                     P=0.651         P=0.125N       |                     P=0.495N        P=0.508        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE   5
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         10 PPM          25 PPM        |      CONTROL         10 PPM          25 PPM        |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    12/50 (24%)      5/49 (10%)      2/49 (4%)      |     3/48 (6%)       2/49 (4%)       4/49 (8%)      |
|ADJUSTED (b)           |     32.2%           15.1%            4.9%          |      8.0%            5.4%           11.0%          |
|TERMINAL (d)           |     8/33 (24%)      4/30 (13%)      2/41 (5%)      |     2/36 (6%)       2/37 (5%)       3/34 (9%)      |
|FIRST INCIDENCE (DAYS) |      687             358             731 (T)       |      714             731 (T)         464           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.001N**      P=0.089N        P=0.002N**     |     P=0.362         P=0.490N        P=0.458        |
|INCIDENTAL TUMOR       |     P=0.002N**      P=0.092N        P=0.005N**     |     P=0.342         P=0.470N        P=0.426        |
|LOGISTIC REGRESSION    |     P=0.003N**      P=0.065N        P=0.002N**     |     P=0.363         P=0.495N        P=0.464        |
|COCHRAN-ARMITAGE       |     P=0.004N**                                     |     P=0.410                                        |
|FISHER EXACT           |                     P=0.059N        P=0.004N**     |                     P=0.490N        P=0.512        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     2/48 (4%)       0/49 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      5.6%            0.0%            0.0%          |
|TERMINAL (d)           |     0/33 (0%)       0/30 (0%)       0/41 (0%)      |     2/36 (6%)       0/37 (0%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      731 (T)         ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.142N        P=0.232N        P=0.251N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.142N        P=0.232N        P=0.251N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.142N        P=0.232N        P=0.251N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.131N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.242N        P=0.237N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE   6
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         10 PPM          25 PPM        |      CONTROL         10 PPM          25 PPM        |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/45 (2%)       0/11 (0%)       1/47 (2%)      |     8/46 (17%)      3/5 (60%)       2/47 (4%)      |
|ADJUSTED (b)           |      3.4%            0.0%            2.5%          |     21.6%          100.0%            6.1%          |
|TERMINAL (d)           |     1/29 (3%)       0/0             1/40 (3%)      |     6/34 (18%)      3/3 (100%)      2/33 (6%)      |
|FIRST INCIDENCE (DAYS) |      731 (T)         ---             731 (T)       |      700             731 (T)         731 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.580N          (e)           P=0.688N       |     P=0.044N*       P=0.214         P=0.060N       |
|INCIDENTAL TUMOR       |     P=0.580N          (e)           P=0.688N       |     P=0.060N        P=0.007 **      P=0.077N       |
|LOGISTIC REGRESSION    |     P=0.580N          (e)           P=0.688N       |     P=0.055N        P=0.011 *       P=0.068N       |
|COCHRAN-ARMITAGE       |     P=0.673                                        |     P=0.033N*                                      |
|FISHER EXACT           |                     P=0.804N        P=0.742N       |                     P=0.061         P=0.042N*      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       1/50 (2%)      |     0/48 (0%)       2/49 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            2.3%          |      0.0%            4.6%            0.0%          |
|TERMINAL (d)           |     0/33 (0%)       0/30 (0%)       0/41 (0%)      |     0/36 (0%)       0/37 (0%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             703           |      ---             679             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.321           (e)           P=0.535        |     P=0.660N        P=0.242           (e)          |
|INCIDENTAL TUMOR       |     P=0.184           (e)           P=0.362        |     P=0.681         P=0.284           (e)          |
|LOGISTIC REGRESSION    |     P=0.287           (e)           P=0.501        |     P=0.619N        P=0.235           (e)          |
|COCHRAN-ARMITAGE       |     P=0.284                                        |     P=0.604N                                       |
|FISHER EXACT           |                       (e)           P=0.500        |                     P=0.253           (e)          |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE   7
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         10 PPM          25 PPM        |      CONTROL         10 PPM          25 PPM        |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       1/50 (2%)      |     0/48 (0%)       2/49 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |      0.0%            0.0%            2.3%          |      0.0%            4.6%            2.9%          |
|TERMINAL (d)           |     0/33 (0%)       0/30 (0%)       0/41 (0%)      |     0/36 (0%)       0/37 (0%)       1/34 (3%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             703           |      ---             679             731 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.321           (e)           P=0.535        |     P=0.399         P=0.242         P=0.489        |
|INCIDENTAL TUMOR       |     P=0.184           (e)           P=0.362        |     P=0.308         P=0.284         P=0.489        |
|LOGISTIC REGRESSION    |     P=0.287           (e)           P=0.501        |     P=0.420         P=0.235         P=0.489        |
|COCHRAN-ARMITAGE       |     P=0.284                                        |     P=0.455                                        |
|FISHER EXACT           |                       (e)           P=0.500        |                     P=0.253         P=0.510        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, or Sarcoma                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       1/50 (2%)      |     0/48 (0%)       2/49 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |      0.0%            0.0%            2.3%          |      0.0%            4.6%            2.9%          |
|TERMINAL (d)           |     0/33 (0%)       0/30 (0%)       0/41 (0%)      |     0/36 (0%)       0/37 (0%)       1/34 (3%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             703           |      ---             679             731 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.321           (e)           P=0.535        |     P=0.399         P=0.242         P=0.489        |
|INCIDENTAL TUMOR       |     P=0.184           (e)           P=0.362        |     P=0.308         P=0.284         P=0.489        |
|LOGISTIC REGRESSION    |     P=0.287           (e)           P=0.501        |     P=0.420         P=0.235         P=0.489        |
|COCHRAN-ARMITAGE       |     P=0.284                                        |     P=0.455                                        |
|FISHER EXACT           |                       (e)           P=0.500        |                     P=0.253         P=0.510        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE   8
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         10 PPM          25 PPM        |      CONTROL         10 PPM          25 PPM        |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/49 (0%)       1/14 (7%)       0/49 (0%)      |     0/47 (0%)       3/13 (23%)      0/49 (0%)      |
|ADJUSTED (b)           |      0.0%           25.0%            0.0%          |      0.0%           36.2%            0.0%          |
|TERMINAL (d)           |     0/33 (0%)       1/4 (25%)       0/41 (0%)      |     0/36 (0%)       1/3 (33%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             731 (T)         ---           |      ---             657             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.624N        P=0.103           (e)          |     P=0.578N        P=0.032 *         (e)          |
|INCIDENTAL TUMOR       |     P=0.624N        P=0.103           (e)          |     P=0.664N        P=0.026 *         (e)          |
|LOGISTIC REGRESSION    |     P=0.624N        P=0.103           (e)          |     P=0.532N        P=0.005 **        (e)          |
|COCHRAN-ARMITAGE       |     P=0.676N                                       |     P=0.504N                                       |
|FISHER EXACT           |                     P=0.222           (e)          |                     P=0.008 **        (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/49 (6%)       0/9 (0%)        0/47 (0%)      |     1/48 (2%)       0/2 (0%)        0/42 (0%)      |
|ADJUSTED (b)           |      9.1%            0.0%            0.0%          |      2.8%            0.0%            0.0%          |
|TERMINAL (d)           |     3/33 (9%)       0/0             0/41 (0%)      |     1/36 (3%)       0/0             0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      731 (T)         ---             ---           |      731 (T)         ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.054N          (e)           P=0.086N       |     P=0.366N          (e)           P=0.523N       |
|INCIDENTAL TUMOR       |     P=0.054N          (e)           P=0.086N       |     P=0.366N          (e)           P=0.523N       |
|LOGISTIC REGRESSION    |     P=0.054N          (e)           P=0.086N       |     P=0.366N          (e)           P=0.523N       |
|COCHRAN-ARMITAGE       |     P=0.080N                                       |     P=0.368N                                       |
|FISHER EXACT           |                     P=0.597N        P=0.129N       |                     P=0.960N        P=0.533N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE   9
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         10 PPM          25 PPM        |      CONTROL         10 PPM          25 PPM        |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/49 (8%)       0/9 (0%)        0/47 (0%)      |     1/48 (2%)       0/2 (0%)        0/42 (0%)      |
|ADJUSTED (b)           |     11.1%            0.0%            0.0%          |      2.8%            0.0%            0.0%          |
|TERMINAL (d)           |     3/33 (9%)       0/0             0/41 (0%)      |     1/36 (3%)       0/0             0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      588             ---             ---           |      731 (T)         ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.026N*       P=0.518N        P=0.046N*      |     P=0.366N          (e)           P=0.523N       |
|INCIDENTAL TUMOR       |     P=0.029N*       P=0.331N        P=0.086N       |     P=0.366N          (e)           P=0.523N       |
|LOGISTIC REGRESSION    |     P=0.040N*       P=0.509N        P=0.070N       |     P=0.366N          (e)           P=0.523N       |
|COCHRAN-ARMITAGE       |     P=0.041N*                                      |     P=0.368N                                       |
|FISHER EXACT           |                     P=0.499N        P=0.064N       |                     P=0.960N        P=0.533N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     2/48 (4%)       1/49 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |                                                    |      5.6%            2.7%            0.0%          |
|TERMINAL (d)           |                                                    |     2/36 (6%)       1/37 (3%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      731 (T)         731 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.169N        P=0.490N        P=0.251N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.169N        P=0.490N        P=0.251N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.169N        P=0.490N        P=0.251N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.154N                                       |
|FISHER EXACT           |                                                    |                     P=0.492N        P=0.237N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE  10
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         10 PPM          25 PPM        |      CONTROL         10 PPM          25 PPM        |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     2/48 (4%)       2/49 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |                                                    |      5.6%            5.4%            0.0%          |
|TERMINAL (d)           |                                                    |     2/36 (6%)       2/37 (5%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      731 (T)         731 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.183N        P=0.685N        P=0.251N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.183N        P=0.685N        P=0.251N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.183N        P=0.685N        P=0.251N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.164N                                       |
|FISHER EXACT           |                                                    |                     P=0.684N        P=0.237N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       1/50 (2%)       1/50 (2%)      |     0/48 (0%)       4/49 (8%)       0/50 (0%)      |
|ADJUSTED (b)           |      2.1%            3.3%            2.4%          |      0.0%            9.5%            0.0%          |
|TERMINAL (d)           |     0/33 (0%)       1/30 (3%)       1/41 (2%)      |     0/36 (0%)       2/37 (5%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      529             731 (T)         731 (T)       |      ---             657             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.618N        P=0.747         P=0.739N       |     P=0.558N        P=0.072           (e)          |
|INCIDENTAL TUMOR       |     P=0.575         P=0.750         P=0.543        |     P=0.636N        P=0.080           (e)          |
|LOGISTIC REGRESSION    |     P=0.660N        P=0.748N        P=0.749N       |     P=0.538N        P=0.063           (e)          |
|COCHRAN-ARMITAGE       |     P=0.665                                        |     P=0.503N                                       |
|FISHER EXACT           |                     P=0.753N        P=0.753N       |                     P=0.061           (e)          |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE  11
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         10 PPM          25 PPM        |      CONTROL         10 PPM          25 PPM        |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       1/50 (2%)       2/50 (4%)      |     1/48 (2%)       5/49 (10%)      0/50 (0%)      |
|ADJUSTED (b)           |      2.1%            3.3%            4.9%          |      2.8%           11.4%            0.0%          |
|TERMINAL (d)           |     0/33 (0%)       1/30 (3%)       2/41 (5%)      |     1/36 (3%)       2/37 (5%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      529             731 (T)         731 (T)       |      731 (T)         582             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.449         P=0.747         P=0.548        |     P=0.348N        P=0.119         P=0.511N       |
|INCIDENTAL TUMOR       |     P=0.312         P=0.750         P=0.287        |     P=0.419N        P=0.084         P=0.511N       |
|LOGISTIC REGRESSION    |     P=0.387         P=0.748N        P=0.508        |     P=0.297N        P=0.098         P=0.511N       |
|COCHRAN-ARMITAGE       |     P=0.387                                        |     P=0.292N                                       |
|FISHER EXACT           |                     P=0.753N        P=0.500        |                     P=0.107         P=0.490N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/50 (14%)      3/50 (6%)       0/50 (0%)      |    16/48 (33%)      9/49 (18%)      8/50 (16%)     |
|ADJUSTED (b)           |     20.2%            9.1%            0.0%          |     37.0%           21.2%           20.8%          |
|TERMINAL (d)           |     6/33 (18%)      2/30 (7%)       0/41 (0%)      |     9/36 (25%)      4/37 (11%)      4/34 (12%)     |
|FIRST INCIDENCE (DAYS) |      670             632             ---           |      672             665             603           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.003N**      P=0.203N        P=0.004N**     |     P=0.095N        P=0.101N        P=0.105N       |
|INCIDENTAL TUMOR       |     P=0.004N**      P=0.166N        P=0.006N**     |     P=0.170N        P=0.026N*       P=0.198N       |
|LOGISTIC REGRESSION    |     P=0.005N**      P=0.186N        P=0.006N**     |     P=0.076N        P=0.029N*       P=0.089N       |
|COCHRAN-ARMITAGE       |     P=0.006N**                                     |     P=0.037N*                                      |
|FISHER EXACT           |                     P=0.159N        P=0.006N**     |                     P=0.073N        P=0.039N*      |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE  12
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         10 PPM          25 PPM        |      CONTROL         10 PPM          25 PPM        |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/50 (14%)      3/50 (6%)       0/50 (0%)      |    16/48 (33%)      9/49 (18%)      8/50 (16%)     |
|ADJUSTED (b)           |     20.2%            9.1%            0.0%          |     37.0%           21.2%           20.8%          |
|TERMINAL (d)           |     6/33 (18%)      2/30 (7%)       0/41 (0%)      |     9/36 (25%)      4/37 (11%)      4/34 (12%)     |
|FIRST INCIDENCE (DAYS) |      670             632             ---           |      672             665             603           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.003N**      P=0.203N        P=0.004N**     |     P=0.095N        P=0.101N        P=0.105N       |
|INCIDENTAL TUMOR       |     P=0.004N**      P=0.166N        P=0.006N**     |     P=0.170N        P=0.026N*       P=0.198N       |
|LOGISTIC REGRESSION    |     P=0.005N**      P=0.186N        P=0.006N**     |     P=0.076N        P=0.029N*       P=0.089N       |
|COCHRAN-ARMITAGE       |     P=0.006N**                                     |     P=0.037N*                                      |
|FISHER EXACT           |                     P=0.159N        P=0.006N**     |                     P=0.073N        P=0.039N*      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    21/50 (42%)      7/50 (14%)     10/50 (20%)     |    16/48 (33%)     11/49 (22%)      7/50 (14%)     |
|ADJUSTED (b)           |     54.8%           22.4%           24.4%          |     40.6%           28.5%           19.3%          |
|TERMINAL (d)           |    16/33 (48%)      6/30 (20%)     10/41 (24%)     |    13/36 (36%)     10/37 (27%)      6/34 (18%)     |
|FIRST INCIDENCE (DAYS) |      588             695             731 (T)       |      692             582              42           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.003N**      P=0.005N**      P=0.003N**     |     P=0.036N*       P=0.169N        P=0.045N*      |
|INCIDENTAL TUMOR       |     P=0.007N**      P=0.004N**      P=0.008N**     |     P=0.023N*       P=0.173N        P=0.032N*      |
|LOGISTIC REGRESSION    |     P=0.006N**      P=0.003N**      P=0.007N**     |     P=0.034N*       P=0.160N        P=0.041N*      |
|COCHRAN-ARMITAGE       |     P=0.017N*                                      |     P=0.018N*                                      |
|FISHER EXACT           |                     P=0.002N**      P=0.015N*      |                     P=0.166N        P=0.021N*      |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE  13
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         10 PPM          25 PPM        |      CONTROL         10 PPM          25 PPM        |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    18/50 (36%)     16/50 (32%)     13/50 (26%)     |    22/48 (46%)     18/49 (37%)     12/50 (24%)     |
|ADJUSTED (b)           |     42.2%           38.5%           30.2%          |     50.0%           39.0%           29.9%          |
|TERMINAL (d)           |    10/33 (30%)      7/30 (23%)     11/41 (27%)     |    14/36 (39%)      9/37 (24%)      6/34 (18%)     |
|FIRST INCIDENCE (DAYS) |      514             358             702           |      672             657             464           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.082N        P=0.525N        P=0.091N       |     P=0.075N        P=0.282N        P=0.080N       |
|INCIDENTAL TUMOR       |     P=0.327N        P=0.317N        P=0.404N       |     P=0.133N        P=0.103N        P=0.149N       |
|LOGISTIC REGRESSION    |     P=0.388N        P=0.340N        P=0.194N       |     P=0.074N        P=0.236N        P=0.059N       |
|COCHRAN-ARMITAGE       |     P=0.169N                                       |     P=0.016N*                                      |
|FISHER EXACT           |                     P=0.417N        P=0.194N       |                     P=0.241N        P=0.019N*      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    33/50 (66%)     23/50 (46%)     20/50 (40%)     |    29/48 (60%)     27/49 (55%)     17/50 (34%)     |
|ADJUSTED (b)           |     73.0%           56.0%           46.5%          |     65.9%           57.3%           41.1%          |
|TERMINAL (d)           |    21/33 (64%)     13/30 (43%)     18/41 (44%)     |    21/36 (58%)     17/37 (46%)     10/34 (29%)     |
|FIRST INCIDENCE (DAYS) |      514             358             702           |      672             582              42           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.002N**      P=0.142N        P=0.001N**     |     P=0.047N*       P=0.399N        P=0.053N       |
|INCIDENTAL TUMOR       |     P=0.017N*       P=0.039N*       P=0.021N*      |     P=0.050N*       P=0.259N        P=0.059N       |
|LOGISTIC REGRESSION    |     P=0.009N**      P=0.034N*       P=0.007N**     |     P=0.019N*       P=0.211N        P=0.028N*      |
|COCHRAN-ARMITAGE       |     P=0.009N**                                     |     P=0.005N**                                     |
|FISHER EXACT           |                     P=0.035N*       P=0.008N**     |                     P=0.373N        P=0.008N**     |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 02                                                 PAGE  14
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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