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TDMS Study 05070-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           VINYL TOLUENE


NTP Experiment-Test: 05070-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:04




       Facility:  Midwest Research Institute

       Chemical CAS #:  25013154

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05070-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           21           18                                                  
    Natural Death                                      3            1            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           28           26                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (5)          (46)                                                
   Intestine Large, Colon                             (50)         (10)         (49)                                                
   Intestine Large, Rectum                            (46)         (9)          (46)                                                
   Intestine Small, Duodenum                          (50)         (9)          (50)                                                
   Intestine Small, Ileum                             (48)         (7)          (48)                                                
   Intestine Small, Jejunum                           (48)         (7)          (49)                                                
   Liver                                              (50)         (33)         (50)                                                
   Mesentery                                          (4)          (2)          (5)                                                 
      Fibrosarcoma, Metastatic, Skin                                1 (50%)                                                         
      Fat, Lipoma                                      1 (25%)                                                                      
   Pancreas                                           (50)         (13)         (49)                                                
      Carcinoma                                        1 (2%)                                                                       
   Salivary Glands                                    (50)         (9)          (47)                                                
   Stomach, Forestomach                               (49)         (11)         (49)                                                
   Stomach, Glandular                                 (50)         (11)         (50)                                                
   Tongue                                                                       (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (50)                                                
      Hemangiosarcoma, Metastatic, Uncertain                                                                                        
          Primary Site                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (14)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (48)         (14)         (45)                                                
      Pheochromocytoma Malignant                       2 (4%)                    1 (2%)                                             
      Pheochromocytoma Benign                          5 (10%)                   3 (7%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 05070-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Islets, Pancreatic                                 (50)         (12)         (49)                                                
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Carcinoma                                        1 (2%)       1 (8%)       2 (4%)                                             
   Pituitary Gland                                    (50)         (43)         (50)                                                
      Pars Distalis, Adenoma                          25 (50%)     24 (56%)     24 (48%)                                            
      Pars Distalis, Adenoma, Multiple                              1 (2%)       1 (2%)                                             
      Pars Distalis, Adenoma, Two                      3 (6%)       1 (2%)       4 (8%)                                             
      Pars Distalis, Carcinoma                         4 (8%)       2 (5%)       1 (2%)                                             
   Thyroid Gland                                      (50)         (10)         (50)                                                
      Carcinoma                                                                  1 (2%)                                             
      C-Cell, Adenoma                                  7 (14%)                   2 (4%)                                             
      C-Cell, Carcinoma                                                          2 (4%)                                             
      Follicular Cell, Adenoma, Papillary                                        1 (2%)                                             
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (11)         (46)                                                
      Adenoma                                          1 (2%)       2 (18%)      2 (4%)                                             
      Carcinoma                                                     2 (18%)                                                         
      Duct, Squamous Cell Papilloma                    1 (2%)                                                                       
   Ovary                                              (50)         (18)         (50)                                                
   Uterus                                             (50)         (18)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Leiomyoma                                                     1 (6%)       1 (2%)                                             
      Leiomyosarcoma                                   1 (2%)       1 (6%)                                                          
      Polyp Stromal                                    7 (14%)      6 (33%)      5 (10%)                                            
      Sarcoma Stromal                                  1 (2%)                                                                       
   Vagina                                             (1)                       (1)                                                 
      Schwannoma Malignant                                                       1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (9)          (50)                                                
   Lymph Node                                         (50)         (17)         (50)                                                
   Lymph Node, Mandibular                             (47)         (11)         (47)                                                
   Lymph Node, Mesenteric                             (47)         (12)         (46)                                                
   Spleen                                             (50)         (19)         (50)                                                
   Thymus                                             (38)         (6)          (37)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05070-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (29)         (49)                                                
      Adenocarcinoma                                   3 (6%)                    2 (4%)                                             
      Adenoma                                                       1 (3%)       1 (2%)                                             
      Carcinoma                                                     1 (3%)                                                          
      Fibroadenoma                                    13 (27%)      8 (28%)      9 (18%)                                            
      Fibroadenoma, Multiple                           1 (2%)                                                                       
      Fibroadenoma, Two                                2 (4%)                                                                       
   Skin                                               (50)         (13)         (50)                                                
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     3 (6%)       2 (15%)      1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (8%)       1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Myxoma                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (9)          (50)                                                
      Sternum, Osteosarcoma                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
   Trachea                                            (50)         (8)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05070-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (14)         (50)                                                
   Urinary Bladder                                    (49)         (9)          (46)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            20 (40%)     16 (32%)     25 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05070-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          41          46                                                   
     Total Primary Neoplasms                          108          70          97                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 44          34          39                                                   
     Total Benign Neoplasms                            73          46          57                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          23          31                                                   
     Total Malignant Neoplasms                         35          24          40                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           2                                                   
     Total Metastatic Neoplasm                                      1           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05070-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                24           29           28                                                  
    Natural Death                                      6            4            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                19           17           19                                                  
  Wrong Sex                                            1                                                                            
  Animals Examined Microscopically                    49           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (43)         (9)          (47)                                                
   Intestine Large, Colon                             (46)         (13)         (49)                                                
      Serosa, Carcinoma, Metastatic, Intestine                                                                                      
          Small                                        1 (2%)                                                                       
   Intestine Small, Ileum                             (44)         (12)         (44)                                                
      Jejunum, Adenocarcinoma, Mucinous                                          1 (2%)                                             
   Intestine Small, Jejunum                           (45)         (13)         (47)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (49)         (42)         (50)                                                
      Fibrosarcoma, Metastatic                         1 (2%)                                                                       
      Neoplastic Nodule                                2 (4%)       2 (5%)       1 (2%)                                             
   Mesentery                                          (8)          (4)          (6)                                                 
      Fat, Adenocarcinoma, Metastatic, Intestine                                                                                    
          Small                                        1 (13%)                                                                      
   Pancreas                                           (46)         (19)         (49)                                                
   Pharynx                                            (1)          (1)          (1)                                                 
      Palate, Squamous Cell Papilloma                  1 (100%)     1 (100%)                                                        
   Salivary Glands                                    (48)         (18)         (50)                                                
      Fibrosarcoma                                                  1 (6%)                                                          
   Stomach, Forestomach                               (48)         (13)         (49)                                                
   Stomach, Glandular                                 (47)         (14)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (14)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05070-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (24)         (50)                                                
   Adrenal Gland, Cortex                              (49)         (20)         (50)                                                
      Adenoma                                          2 (4%)                                                                       
      Carcinoma                                                                  1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (21)         (46)                                                
      Pheochromocytoma Malignant                       1 (2%)       3 (14%)      2 (4%)                                             
      Pheochromocytoma Complex                         3 (6%)                    1 (2%)                                             
      Pheochromocytoma Benign                         11 (22%)      6 (29%)     11 (24%)                                            
      Pheochromocytoma Benign, Multiple                3 (6%)                    3 (7%)                                             
   Islets, Pancreatic                                 (46)         (16)         (49)                                                
      Adenoma                                          5 (11%)      3 (19%)      5 (10%)                                            
      Adenoma, Two                                     1 (2%)                                                                       
      Carcinoma                                                                  1 (2%)                                             
   Parathyroid Gland                                  (45)         (14)         (45)                                                
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (49)         (35)         (50)                                                
      Pars Distalis, Adenoma                          27 (55%)     20 (57%)     28 (56%)                                            
      Pars Distalis, Adenoma, Multiple                 1 (2%)                    1 (2%)                                             
      Pars Distalis, Adenoma, Two                      3 (6%)       1 (3%)       1 (2%)                                             
      Pars Distalis, Carcinoma                         3 (6%)       1 (3%)       1 (2%)                                             
   Thyroid Gland                                      (49)         (20)         (50)                                                
      Bilateral, C-Cell, Adenoma                                                 1 (2%)                                             
      C-Cell, Adenoma                                  7 (14%)      2 (10%)      6 (12%)                                            
      C-Cell, Carcinoma                                1 (2%)       1 (5%)       1 (2%)                                             
      Follicular Cell, Carcinoma                                    2 (10%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                       (1)                                                 
      Lipoma                                           1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (47)         (16)         (50)                                                
   Preputial Gland                                    (46)         (18)         (48)                                                
      Adenoma                                          1 (2%)                    2 (4%)                                             
      Carcinoma                                        1 (2%)       2 (11%)      1 (2%)                                             
   Prostate                                           (49)         (18)         (49)                                                
      Adenoma                                          1 (2%)                                                                       
   Seminal Vesicle                                    (41)         (13)         (43)                                                
      Adenocarcinoma, Metastatic, Intestine Small      1 (2%)                                                                       
   Testes                                             (49)         (42)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           25 (51%)     21 (50%)     33 (66%)                                            
      Interstitial Cell, Adenoma                      10 (20%)     10 (24%)      8 (16%)                                            
                                                             Page   8                                                               
NTP Experiment-Test: 05070-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (15)         (50)                                                
   Lymph Node                                         (49)         (27)         (50)                                                
      Inguinal, Renal, Adenocarcinoma, Metastatic,                                                                                  
           Intestine Small                             1 (2%)                                                                       
      Mediastinal, Pheochromocytoma Malignant,                                                                                      
           Metastatic, Adrenal Gland                                1 (4%)                                                          
   Lymph Node, Mandibular                             (44)         (14)         (48)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
   Lymph Node, Mesenteric                             (44)         (17)         (48)                                                
   Spleen                                             (49)         (35)         (49)                                                
   Thymus                                             (38)         (14)         (38)                                                
      Thymoma Malignant                                                          1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (38)         (20)         (46)                                                
      Adenocarcinoma                                                1 (5%)       1 (2%)                                             
      Fibroadenoma                                     1 (3%)                    1 (2%)                                             
   Skin                                               (49)         (23)         (50)                                                
      Basosquamous Tumor Benign                                     1 (4%)                                                          
      Keratoacanthoma                                  2 (4%)       3 (13%)      5 (10%)                                            
      Keratoacanthoma, Two                                          1 (4%)                                                          
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
      Trichoepithelioma                                                          1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     2 (4%)       1 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                3 (6%)       1 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Neurofibroma                                          1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)       1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (4)          (1)                                                 
      Hindlimb, Rhabdomyosarcoma                                    1 (25%)                                                         
      Intercostal, Fibroma                                          1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (15)         (50)                                                
      Astrocytoma NOS                                  1 (2%)                                                                       
      Carcinoma, Early Invasion                        1 (2%)                                                                       
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
                                                             Page   9                                                               
NTP Experiment-Test: 05070-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - cont                                                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (37)         (5)          (41)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (3%)                                                                       
   Lung                                               (49)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                    1 (2%)                                             
      Fibrosarcoma, Metastatic                         1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                             1 (2%)                                                          
      Pheochromocytoma Complex, Metastatic             1 (2%)                                                                       
   Trachea                                            (48)         (14)         (50)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Right, Carcinoma                                              1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (35)         (50)                                                
      Lipoma                                                                     2 (4%)                                             
      Sarcoma                                                                    1 (2%)                                             
   Urinary Bladder                                    (48)         (12)         (49)                                                
      Transitional Epithelium, Papilloma                                         2 (4%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(49)        *(50)        *(50)                                                
      Leukemia Mononuclear                            25 (51%)     26 (52%)     20 (40%)                                            
      Mesothelioma Benign                                                        1 (2%)                                             
      Mesothelioma Malignant                           3 (6%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05070-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          50          50                                                   
     Total Primary Neoplasms                          152         116         149                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          45          49                                                   
     Total Benign Neoplasms                           108          73         115                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              38          37          29                                                   
     Total Malignant Neoplasms                         43          43          34                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           1           1                                                   
     Total Metastatic Neoplasm                         12           2           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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                             ----------              END OF REPORT             ----------                                           
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--multipart-boundary
Content-type: text/plain
Range: bytes 64858-64858/64858


--multipart-boundary--