National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2135

TDMS Study 05075-01 Pathology Tables

NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97
Route: DOSED FEED                                                                                                 Time: 06:58:25




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57-41-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|             
                                           | 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X           X     X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                 X   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                       X  X                       X           X     X   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                              +         |             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X           X     X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                          X           X     X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |       X                                      X                           |             
      Leukemia Mononuclear                 |                            X                       X           X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                       X           X         |             
      Pheochromocytoma Benign              |                                           X                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X           X  X     X  X  X  X  X     X        X     X  X  X     X   |             
      Pars Distalis, Carcinoma             |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|             
                                           | 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                             X            |             
      C-Cell, Adenoma                      |             X                 X  X  X        X                           |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenocarcinoma      |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Adenoma                              |                               X                                          |             
      Carcinoma                            |                                                             X            |             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                                                 X                        |             
      Leukemia Mononuclear                 |                                                    X                 X   |             
      Polyp Stromal                        |                            X           X                                 |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                                                X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                      X   |             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                    X                     |             
      Inguinal, Leukemia Mononuclear       |                                                                      X   |             
      Mandibular, Leukemia Mononuclear     |                            X                       X           X     X   |             
      Mediastinal, Leukemia Mononuclear    |                         X                                      X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                +         |             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                       X  X                       X           X     X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                                                    X           X         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                              X     X           X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|             
                                           | 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |          X     X     X        X           X                 X        X   |             
      Fibroadenoma, Multiple               |                                                                          |             
      Leukemia Mononuclear                 |                                                    X           X     X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                      X   |             
      Squamous Cell Carcinoma              |                                                                          |             
      Trichoepithelioma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                            +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X           X         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |                         X  X                       X           X     X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nares, Leukemia Mononuclear          |                                                                      X   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                          +     +         |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                    +  +                                             |             
      Lids, Fibrosarcoma                   |    X                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                          X           X     X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X           X     X   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                       X  X                       X           X     X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3|            |
                                           | 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X  X        X        X        X  X  X                  |         13 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   3        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                    X                     |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          2 |
      Leukemia Mononuclear                 |                               X                 X  X                     |          6 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                 X  X                     |          5 |
      Pheochromocytoma Benign              |                               X        X  X                              |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   5                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3|            |
                                           | 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |       X     X  X     X  X  X  X        X  X  X                 X         |         25 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |       X        X                 X              X  X           X        X|         12 |
      C-Cell, Carcinoma                    |                                           X           X                  |          2 |
      Follicular Cell, Adenocarcinoma      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Adenoma                              |             X                 X                                X         |          4 |
      Carcinoma                            |                   X                                                      |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leiomyosarcoma                       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Polyp Stromal                        |             X                 X     X                             X      |          6 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |          +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Leukemia Mononuclear        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |            |
           Thyroid Gland                   |                                                       X                  |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |                   X  X        X        X        X                        |          9 |
      Mediastinal, Leukemia Mononuclear    |                                                 X  X                     |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3|            |
                                           | 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X  X        X        X        X  X  X                  |         13 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Leukemia Mononuclear                 |                   X                             X  X                     |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                                                          |          3 |
      Adenoma                              |                X                                                         |          1 |
      Fibroadenoma                         | X  X  X                    X     X     X              X        X  X      |         16 |
      Fibroadenoma, Multiple               |                                                                         X|          1 |
      Leukemia Mononuclear                 |                                                 X                        |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Keratoacanthoma                      |                            X                                             |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                          X               |          1 |
      Trichoepithelioma                    |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                X         |          1 |
      Leukemia Mononuclear                 |                   X  X        X        X        X  X                     |         11 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nares, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +                                                               |   3        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3|            |
                                           | 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +  +                    +     +                    +              +|   9        |
      Lids, Fibrosarcoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                 +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                 X                        |          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X  X        X        X        X  X  X                  |         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|             
                                           | 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X           X                          X  X  X  X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Carcinoma, Metastatic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Adenoma                              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +        +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
      Pars Distalis, Adenoma               | X  X     X  X  X  X  X  X  X  X     X  X  X  X              X        X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                        X     X  X           X        X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|             
                                           | 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +     +     +        +  +     M     +  +  +  +           +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +     +     +        +  +  +  +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +     +  +  +  +  +     +     +  +  +  +           +        +   |             
      Polyp Stromal                        |    X  X           X                                                      |             
      Polyp Stromal, Multiple              |                                                                          |             
      Sarcoma Stromal                      |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +  +        +  +     +     +  +  +  +           +        +   |             
      Deep Cervical, Leukemia Mononuclear  |    X                                                                     |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mandibular, Leukemia Mononuclear     |    X        X                                               X            |             
      Mediastinal, Leukemia Mononuclear    |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             +            |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +        +  +     +     +  +  +  +  +     +  +        +   |             
      Leukemia Mononuclear                 |    X     X  X           X                 X        X     X  X            |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +     +        I  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +        +  +  +  +     +  +  +  +           +        +   |             
      Adenocarcinoma                       | X                                                           X            |             
      Adenoma                              |             X                                                            |             
      Fibroadenoma                         |          X     X        X     X  X     X  X                          X   |             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |       X                                                                  |             
      Subcutaneous Tissue, Fibrosarcoma    |                            X                                             |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +     +        +  +     +     +  +  +  +           +        +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +     +        +  +     +     +  +  +  +           +        +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|             
                                           | 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +     +        +  +     +     +  +  +  +           +  +     +   |             
      Leukemia Mononuclear                 |    X     X                                X                 X            |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +     +        +  +     +     +  +  +  +           +        +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +              +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +     +        +  +     +  +  +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X           X                 X        X  X  X  X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1|            |
                                           | 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                   +  +  +           +  +     +           +     +        +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                   +  +  +           +  +     +           +     A        +|  20        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Leukemia Mononuclear                 |                   X                 X        X                    X  X  X|         14 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                 +     +  +  +                                         +|   6        |
      Leukemia Mononuclear                 |                   X                                                     X|          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                   +  +  +           +  +     +           +     A        +|  20        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                   +  +  +           +  +     +           +     +        +|  21        |
      Carcinoma, Metastatic                |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                   +  +  +           +  +     +           +     A        +|  20        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                   +  +  +           +  +     +           +     +        +|  21        |
      Leukemia Mononuclear                 |                   X                 X                                   X|          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                   +  +  +           +  +     +        +  +     A        +|  21        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                   +  +  +           +  +     +        +  +     A        +|  21        |
      Leukemia Mononuclear                 |                   X                 X                                   X|          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                   +  +  +           +  +     +        +  +     A        +|  21        |
      Leukemia Mononuclear                 |                   X                 X                                   X|          4 |
      Pheochromocytoma Malignant           |                                                       X                  |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                   +  +  +           +  +     +           +     A        +|  20        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                   M  +  +           +  +     +           +     M        +|  18        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +     +|  41        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1|            |
                                           | 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                   X                                                     X|          3 |
      Pars Distalis, Adenoma               |             X  X  X        X  X        X           X  X           X      |         26 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                   +  +  +           +  +     +           +     A        +|  20        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
      C-Cell, Adenoma                      |                                        X                                X|          7 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                   +  +  +           +  +     I           +     +        +|  21        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                 +  +  +           +  +     +           +     +        +|  23        |
      Leukemia Mononuclear                 |                   X                                                     X|          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                +  +  +  +           +  +     +     +     +     +        +|  26        |
      Polyp Stromal                        |                                     X                                    |          4 |
      Polyp Stromal, Multiple              |                                              X                           |          1 |
      Sarcoma Stromal                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                   +  +  +           +  +     +           +     +        +|  21        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +  +  +           +  +     +           +     A        +|  21        |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                                         X|          1 |
      Mandibular, Leukemia Mononuclear     |                   X                 X        X                          X|          7 |
      Mediastinal, Leukemia Mononuclear    |                   X                 X        X                          X|          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                   +  +  +           +  +     +           +     +  +  +  +|  26        |
      Leukemia Mononuclear                 |                   X                 X        X                 X  X  X  X|         15 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                   +  +  +           M  +     +           I     +        +|  18        |
      Leukemia Mononuclear                 |                                              X                 X        X|          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                   +  +  +           +  +     +           +  +  A        +|  24        |
      Adenocarcinoma                       |                         X                                                |          3 |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                                                             X            |          9 |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1|            |
                                           | 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                   +  +  +           +  +     +           +     +        +|  22        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                   +  +  +           +  +     +           +     +        +|  21        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                   +  +  +           +  +     +           +     +        +|  21        |
      Leukemia Mononuclear                 |                                                                X         |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                   +  +  +           +  +     +           +     +        +|  22        |
      Leukemia Mononuclear                 |                   X                 X        X                 X        X|          9 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                   +  +  +           +  +     +           +     +        +|  21        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                   +  +  +           +  +     +           +     +        +|  21        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                      +  +                 +   |   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   1        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                          +               |   1        |
      Carcinoma                            |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                   +  +  +           +  +     +           +     +        +|  21        |
      Leukemia Mononuclear                 |                   X                          X                          X|          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                   +  +  +           +  +     +           +     A        +|  21        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                 X        X                 X  X  X  X|         16 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|             
                                           | 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                   +     +        +  +  +     A  +        +  +     +     +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                   +     +        +  +  +     A  +        +  +     +     +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                   +     +        +  +  +     A  +        +  +     +     +|             
      Leukemia Mononuclear                 |                         X              X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X  X           X        X              X        X|             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                   +     +  +     +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                         X                                               X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                   +     +        +  +  +     +  +        +  +     +     +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      Pars Distalis, Adenoma               | X                 X  X     X                 X                       X   |             
      Pars Distalis, Leukemia Mononuclear  |                         X              X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                   +     +        +  +  +     A  +        +  +     +     +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                   X              X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|             
                                           | 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                   +     +  +     +  +  +     +  +        +  +     +     +|             
      Adenoma                              |                            X                    X                 X      |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +  +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Uterus                                  |                   +     +        +  +  +  +  +  +        +  +     +     +|             
      Leiomyosarcoma                       |                                           X                              |             
      Polyp Stromal                        |                   X                                                      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                   +     +        +  +  +     +  +        +  +     +     I|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +     +        +  +  +     +  +        +  +     +     +|             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                         X              X                                X|             
      Mediastinal, Leukemia Mononuclear    |                         X                                               X|             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +                                                      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +     +        +  +  +     A  +     +  +  +     +     +|             
      Hemangioma                           |                                                                          |             
      Leukemia Mononuclear                 |                X        X              X        X     X                 X|             
                                            __________________________________________________________________________|             
   Thymus                                  |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +                 +     +  +     +  +  +  +  +  +        +  +  +  +  +  +|             
      Fibroadenoma                         | X                 X        X              X  X              X  X     X   |             
                                            __________________________________________________________________________|             
   Skin                                    |                   +     +        +  +  +     +  +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                   +     +        +  +  +     +  +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                         X              X        X                       X|             
                                            __________________________________________________________________________|             
   Nose                                    |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |                   +     +        +  +  +     +  +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +     +     +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +              +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|             
                                           | 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                                    |             
      Carcinoma                            |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                         X                                               X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                   +     +        +  +  +     A  +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X  X           X        X     X        X        X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3|            |
                                           | 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +        +  +  +  +  +     +  +           +           +     +         |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
      Leukemia Mononuclear                 |                               X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X     X  X  X  X           X           X     X  X     X        X  X  X|         20 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +  +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Leukemia Mononuclear                 |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +           +  +  +  +     +  +           +  +        +     +         |  22        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +        +  +  +  +  +     +  +           +  +        +     +         |  24        |
      Leukemia Mononuclear                 |    X        X                                   X        X               |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Leukemia Mononuclear                 |                   X           X                 X                        |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Leukemia Mononuclear                 |                   X                             X                        |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Adenoma                              |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M        +  +  +  +  +     +  +           +  M        +     +         |  21        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |  43        |
      Leukemia Mononuclear                 |                                                                   X      |          2 |
      Pars Distalis, Adenoma               | X                       X           X  X  X              X  X  X     X   |         15 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3|            |
                                           | 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +        +  A  +  +  +     +  +           +  +        A     A         |  19        |
      Bilateral, C-Cell, Adenoma           |                                              X                           |          1 |
      C-Cell, Adenoma                      |                   X           X                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +        +  +  +  +  +     +  +           +  +        +     +         |  24        |
      Adenoma                              |                      X                                                   |          4 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +        +  +  +  +  +     +  +  +        +  +        +  +  +         |  26        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +     +  +  +  +  +  +     +  +        +  +  +        +     +         |  26        |
      Leiomyosarcoma                       |                                                                          |          1 |
      Polyp Stromal                        |          X           X        X           X  X                           |          6 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +        +  +  +  +  +     +  +           +  +        +     +         |  22        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +        +  +  +  +  +     +  +        +  +  +        +     +  +  +   |  26        |
      Deep Cervical, Leukemia Mononuclear  |    X                                                                     |          1 |
      Mandibular, Leukemia Mononuclear     |    X        X  X  X           X                 X        X        X      |         11 |
      Mediastinal, Leukemia Mononuclear    |             X  X              X                 X                        |          6 |
      Pancreatic, Leukemia Mononuclear     |                X              X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                               +           +                          +   |   4        |
      Leukemia Mononuclear                 |                               X           X                          X   |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +  +  +  +  +  +     +  +        +  +  +  +     +     +  +  +   |  29        |
      Hemangioma                           |                                                                X         |          1 |
      Leukemia Mononuclear                 |    X     X  X  X  X           X           X     X  X     X        X  X   |         18 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +        +  M  +  +  +     +              +  +        +     +         |  21        |
      Leukemia Mononuclear                 |    X        X                 X                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +        +  +  +  +  +     +  +        +  +  +        +  +  +     +   |  31        |
      Fibroadenoma                         |                      X  X        X        X                 X        X   |         14 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +        +  +  +  +  +     +  +           +  +        +     +         |  24        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3|            |
                                           | 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Leukemia Mononuclear                 |                X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +        +  +  +  +  +     +  +           +  +        +     +  +      |  24        |
      Leukemia Mononuclear                 |    X        X  X  X           X                          X        X      |         11 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +        +  +  +  +  +     +              +  +        +     +         |  22        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +        +                                               +            |   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   3        |
      Leukemia Mononuclear                 |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Leukemia Mononuclear                 |                X              X                 X        X               |          6 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +        +  +  +  +  +     +              +  +        +     A         |  20        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X     X  X  X  X           X           X     X  X     X        X  X  X|         21 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +                    +  +           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +                    +  A           A  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +                    +  A           +  +     +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +                    +  A           A  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +                    +  A           A  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +                    +  A           A  +     +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |    X                                                                     |             
      Leukemia Mononuclear                 |                      X     X  X                 X  X              X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Stomach                                 |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +                    +  A           +  +     +                    +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +                    +  +           +  +     +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +                    +  +           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +                    +  +           +  +     +                    +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +                    +  +           +  +     +                    +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +                    +  A           +  +     +                    +|             
      Adenoma                              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +     +  +        +  +  +  +     +  +     +  +              +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Pars Distalis, Adenoma               | X     X        X  X        X     X  X        X     X  X                  |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +                    +  A           A  +     +                    +|             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       M           +        +  +           +  +     +                    +|             
      Adenoma                              |                                                                          |             
      Squamous Cell Papilloma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +                    +  +           +  +     +  +           +     +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +           +        +  +        +  +  +     +  +              +  +|             
      Polyp Stromal                        | X                                      X  X           X              X   |             
      Sarcoma Stromal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                    +  A           +  +     +                    +|             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                            X                                             |             
      Mediastinal, Leukemia Mononuclear    |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +              +     +  +           +  +  +  +                 +  +|             
      Leukemia Mononuclear                 |                      X     X  X                 X                    X   |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +                    +  A           +  +     +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +           +        +  +           +  +     +                    +|             
      Adenocarcinoma                       |       X                                                                  |             
      Fibroadenoma                         |    X              X                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    |       +                    +  +           +  +     +              +     +|             
      Squamous Cell Papilloma              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +                    +  +           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +                    +  +           +  +     +                    +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +                    +  +           +  +     +                    +|             
      Leukemia Mononuclear                 |                            X  X                    X                     |             
                                            __________________________________________________________________________|             
   Nose                                    |       +                    +  +           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +                    +  +           +  +     +                    +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Sarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                         +  +        +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                         +|             
      Carcinoma                            |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +                    +  +           +  +     +                    +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +                    +  A           +  +     +                    +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X  X                 X  X              X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +           +                       +                       +      |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A           +                       A                       +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A           +                       A                       +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A           +                       A                       +      |  10        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A           +                       A                       +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A           +                       A                       +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A           +                       A                       +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A           +                       A                       +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A           +                       A                       +      |   9        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |                   X                    X                 X               |         10 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A           +                       A                       +      |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +           +                       +                       +      |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  A  +        +                       +                       +      |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  A           +                       +                       +      |  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +        +                       A                       +      |  11        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +           +                       +                       +      |  13        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +           +                       +                       +      |  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +           +                       +                       +      |  13        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +           +                       +                       +      |  13        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A           +                       +                       +      |  11        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +           +                       +                       +      |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +        +  +     +        +     +  +  +  +  +        +  +  +  +|  32        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               | X  X     X                          X        X  X     X        X     X   |         19 |
      Pars Distalis, Carcinoma             |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  A           +                       A                       +      |   9        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Adenoma                      |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +           +        +           +  M                       +      |  14        |
      Adenoma                              |                            X                                      X      |          2 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +           +     +        +  +     +                       +      |  19        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +     +  +  +     +  +        +        +     +        +      |  25        |
      Polyp Stromal                        |             X     X  X  X        X                       X               |         11 |
      Sarcoma Stromal                      | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                          +               |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +           +                       +                       +      |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +           +                       +                       +      |  12        |
      Inguinal, Leukemia Mononuclear       |                   X                                                      |          1 |
      Mandibular, Leukemia Mononuclear     |                   X                                                      |          2 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  A           +                       +              +        +  +   |  17        |
      Leukemia Mononuclear                 |                   X                                      X               |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +           +                       +                       +      |  12        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +           +        +           +  +     +           +     +      |  19        |
      Adenocarcinoma                       |                                                 X                        |          2 |
      Fibroadenoma                         |                   X        X           X                    X            |          6 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +           +                       +                       +      |  14        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +           +                       +                       +      |  13        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +           +                       +                       +      |  13        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +           +                       +                       +      |  13        |
      Leukemia Mononuclear                 |                   X                                                      |          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +           +                       +                       +      |  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +              +                       +                       +      |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                                                   |   1        |
      Pinna, Sarcoma                       |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +  +                                         +                  |   7        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  A           +                       +           +           +      |  13        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A           +                       +                       +      |  11        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                    X                 X               |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|             
                                           | 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Submucosa, Leukemia Mononuclear      |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma, Multiple     |                                                                X         |             
      Leukemia Mononuclear                 |                X                          X                       X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +        +  +                 +  +        +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Endocardium, Schwannoma Benign       |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +        +  +  +              +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +        +  +  +              +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Pheochromocytoma Benign              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +        +  +                 +  +        A        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|             
                                           | 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +        +  +                 +  +        +        +  +     +     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | A  +  +  +  +  +  +        +  +  +  +  +        +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |    X     X  X     X                 X           X           X        X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                                          X              X|             
      Follicular Cell, Adenocarcinoma      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +     +        +  +     +           +  +        +        +  +     +     M|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +     +  +     +           +  +        +        +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +     +  +  +     +        +  +  +  +  +        +  +  +  +  +  +|             
      Adenocarcinoma                       |                                        X                                 |             
      Leiomyoma                            |                                                                X         |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        | X        X        X        X                             X              X|             
      Sarcoma Stromal                      |                      X                                                   |             
      Cervix, Carcinoma Adenosquamous      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                                      +           +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +        +  +                 +  +        +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +        +  +  +              +  +        +        +  +     +     +|             
      Deep Cervical, Leukemia Mononuclear  |                X                                                         |             
      Mandibular, Leukemia Mononuclear     |                X                                                  X     X|             
      Mediastinal, Leukemia Mononuclear    |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +     +                                                  +|             
      Leukemia Mononuclear                 |                X                                                        X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                X                                                  X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +        +  M                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +        +  +                 +  +        +        +  +     +  +  +|             
      Adenoma                              |                                                                      X   |             
      Fibroadenoma                         |                   X                                                     X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +              +  +     +  +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|             
                                           | 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Keratoacanthoma                      |                X                                                         |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |    X                                         X                           |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +        +  +                 +  +        +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                X                                                  X     X|             
                                            __________________________________________________________________________|             
   Nose                                    | +     +        +  +                 +  +        +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Sarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +        +                          +           +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                X                                                        X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                          X                       X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3|            |
                                           | 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +                       +  +  +        +  +     +        +  +     +   |  19        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 | X                                         X                              |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
      Submucosa, Leukemia Mononuclear      | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Leukemia Mononuclear                 | X                             X           X  X           X     X         |         10 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   1        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +                       +  +  +        +  +     +        +  +     +   |  21        |
      Leukemia Mononuclear                 | X                                         X  X                           |          4 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 | X                                            X                           |          3 |
      Endocardium, Schwannoma Benign       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +                       +  +  +        +  +              +  +     +   |  20        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3|            |
                                           | 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 |                                              X                 X         |          3 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +                       +  +  +        +  +     +        +  +     +   |  21        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +                       +  +  M        +  +     +        +  M     +   |  19        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +     +  +        +  +  +        +  M  +  +  +     +  +     +  +|  35        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
      Pars Distalis, Adenoma               |          X     X  X        X                       X                 X  X|         15 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
      C-Cell, Adenoma                      |                                                                      X   |          3 |
      Follicular Cell, Adenocarcinoma      | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +        +              +  +  +     +  +  +     +        +  +     +   |  24        |
      Adenoma                              |             X                    X     X                    X            |          4 |
      Leukemia Mononuclear                 | X                                         X                              |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +        +              +  +  +        +  +     +        +  +     +   |  26        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +              +  +  +  +     +  +  +  +     +  +  +     +   |  35        |
      Adenocarcinoma                       |                                                                          |          1 |
      Leiomyoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                           X                              |          1 |
      Polyp Stromal                        |    X  X     X                 X                 X  X        X            |         13 |
      Sarcoma Stromal                      |                                                                          |          1 |
      Cervix, Carcinoma Adenosquamous      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                      +   |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +                       +  +  +        +  +     +        +  +     +   |  23        |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     | X                             X           X  X                 X         |          8 |
      Mediastinal, Leukemia Mononuclear    |                               X           X  X                 X         |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                               +           +  +                           |   6        |
      Leukemia Mononuclear                 |                               X           X  X                           |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3|            |
                                           | 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +                       +  +  +        +  +     +     +  +  +     +   |  22        |
      Leukemia Mononuclear                 | X                             X           X  X           X     X         |          9 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M                       +  +  +        +  +     +           +     +   |  19        |
      Leukemia Mononuclear                 | X                             X           X  X                           |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +              +  +     +  +  +        +  +     +        +  +     +   |  25        |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                   X  X     X                       X                     |          6 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                       +  +  +  +     +  +     +        +  +     +   |  26        |
      Keratoacanthoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 | X                                                                        |          1 |
      Squamous Cell Papilloma              |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         |                                              X                           |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 | X                                         X                              |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                    +  +  +  +        +  +     +        +  +     +   |  23        |
      Leukemia Mononuclear                 | X                             X           X  X                 X         |          8 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                               +                                          |   1        |
      Pinna, Sarcoma                       |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                         +        +            |   7        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 |                                           X  X                 X         |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3|            |
                                           | 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 | X                                         X                              |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                             X           X  X           X     X         |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|             
                                           | 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +  A        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +  A        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +  A        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                           X           X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +  A        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +  A        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +  A        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +  A        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +  A        +           +     +  +     +  +     +  +         |             
      Adenocarcinoma                       |                                                                          |             
      Leukemia Mononuclear                 |                                     X     X           X                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X              X     X     X           X     X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Pancreas                                |             A  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                     X     X           X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                     X     X                              |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
      Squamous Cell Carcinoma              |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |             X                       X     X           X     X            |             
      Pericardium, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +  +        +           +     +  +     +  +     +  +         |             
      Carcinoma                            |                                              X                           |             
      Leukemia Mononuclear                 |                                     X                 X     X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                     X                 X     X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|             
                                           | 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             A  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +  +  +     +  +  +        +     +  +  +  +  +  +  +  +     +   |             
      Leukemia Mononuclear                 |                                           X           X                  |             
      Pars Distalis, Adenoma               |          X           X  X  X              X              X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +  A        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                     X                                    |             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |          +  +  +        +     +     +     +  +     +  +  +  +  +         |             
      Carcinoma                            |          X                                                               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +  +     +  +     +     +     +  +     +  +        +     +   |             
      Leukemia Mononuclear                 |                                           X           X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +        +  +  +  +  +        +  +  +  +  +     +  +     +  +  +      |             
      Adenocarcinoma                       |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        | X                 X  X                 X                    X     X      |             
      Sarcoma Stromal                      |                                                    X                     |             
      Wall, Leukemia Mononuclear           |                                           X                              |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                 +                    +                    +  +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +  +        +     +     +     +  +     +  +     +  +        +|             
      Deep Cervical, Leukemia Mononuclear  |                                                       X                  |             
      Inguinal, Leukemia Mononuclear       |                                           X                              |             
      Lumbar, Leukemia Mononuclear         |                                                       X                  |             
      Mandibular, Leukemia Mononuclear     |             X                       X     X           X     X            |             
      Mediastinal, Leukemia Mononuclear    |             X                             X           X                  |             
      Renal, Leukemia Mononuclear          |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +                       +           +           +        +         |             
      Leukemia Mononuclear                 |                                           X           X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +  +        +     +     +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |             X  X              X     X     X           X     X            |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |             X                       X     X           X     X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|             
                                           | 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +  +        +           +     +  +  +  +  +     +  +         |             
      Fibroadenoma                         |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Skin                                    |             +  +        +        +  +     +  +     +  +     +  +         |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +  +        +           +     +  +     +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +  +        +           +     +  +     +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +  +        +           +     +  +     +  +     +  +         |             
      Alveolar/Bronchiolar Carcinoma       |                                                                X         |             
      Carcinoma, Metastatic, Adrenal Gland |                                              X                           |             
      Leukemia Mononuclear                 |             X  X                    X     X           X     X            |             
      Sarcoma, Metastatic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +  +        +           +     +  +     +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |    +  +                       +                    +     +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |             X                       X     X           X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +  +        +           +     +  +     +  +     M  +         |             
      Leukemia Mononuclear                 |                                     X                 X                  |             
      Wall, Leukemia Mononuclear           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X              X     X     X           X     X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3|            |
                                           | 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +     +                                +     +           +  +  +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +     +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +     +     +                          +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +     +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +     +                                +     +           +  +  A      |  15        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +     +     +                          +     +           +  +  +      |  17        |
      Adenocarcinoma                       |                X                                                         |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X  X  X                          X              X  X           X|         14 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                             +            |   2        |
      Leukemia Mononuclear                 |                                                             X            |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                             X            |          4 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +     +                                +     +           +  +  +      |  17        |
      Leukemia Mononuclear                 |                                                             X            |          6 |
      Pericardium, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +                                +     +           +  +  +      |  17        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3|            |
                                           | 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +     +                                +     +           +  +  +      |  17        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                             X            |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +     +                                +     +           +  +  +      |  17        |
      Leukemia Mononuclear                 |                                                             X            |          4 |
      Pheochromocytoma Benign              |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +     +                                +     +           +  +  +      |  16        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +              +  +     +  +     +     +  +  +  +  +  +  +  +   |  33        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pars Distalis, Adenoma               |    X     X              X           X              X           X     X   |         13 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +     +                                +     +           +  +  +     +|  17        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                           X                             X|          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +     +                                +     +           +  +  +      |  20        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +           +                    +     +           +  +  +      |  21        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +     +  +     +     +        +  +     +           +  +  +     +|  31        |
      Adenocarcinoma                       |                                                 X                        |          1 |
      Leukemia Mononuclear                 |                                                                         X|          1 |
      Polyp Stromal                        |                X  X     X     X                 X                        |         11 |
      Sarcoma Stromal                      |                                                                          |          1 |
      Wall, Leukemia Mononuclear           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                               +                                         +|   7        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +     +                          +     +           +  +  +     +|  22        |
      Deep Cervical, Leukemia Mononuclear  |                                                                         X|          2 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |                                           X                 X           X|          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3|            |
                                           | 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Leukemia Mononuclear    |                                           X                 X           X|          6 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                         +|   6        |
      Leukemia Mononuclear                 |                                                                         X|          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +  +  +                          +     +           +  +  +     +|  21        |
      Leukemia Mononuclear                 |          X  X  X                          X                 X           X|         13 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +     +                                +     +           +  +  +     M|  17        |
      Leukemia Mononuclear                 |                                                             X            |          6 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +     +     +  +  +     +        +     +     +           +  +  +      |  23        |
      Fibroadenoma                         |                X  X  X                                         X         |          6 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +                                +     +           +  +  +      |  18        |
      Squamous Cell Papilloma              |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +                                +     +           +  +  +      |  17        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +     +                                +     +           +  +  +      |  17        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +                                +     +           +  +  +     +|  18        |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Adrenal Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |                                           X                 X           X|          9 |
      Sarcoma, Metastatic                  |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +     +                                +     +           +  +  +      |  17        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +        +                 +                                   +|   9        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +                                +     +           +  +  +      |  17        |
      Leukemia Mononuclear                 |                                                             X            |          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Wall, Leukemia Mononuclear           |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3|            |
                                           | 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |          X  X  X                          X              X  X           X|         14 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|             
                                           | 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |    X                                                                     |             
      Leukemia Mononuclear                 |          X                 X                    X              X  X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X  X  X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X  X   |             
      Endocardium, Schwannoma Benign       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|             
                                           | 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                X     X           X     X  X     X     X  X  X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                         X           X                       X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                                                          X               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Polyp Stromal                        |                   X        X  X                 X  X                 X   |             
      Endometrium, Adenoma                 |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mandibular, Leukemia Mononuclear     |          X           X     X                    X              X  X  X   |             
      Mediastinal, Leukemia Mononuclear    |          X           X     X                    X                 X  X   |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                       +           +      |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X                    X              X  X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                 X  X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                  X              X                        |             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|             
                                           | 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
      Abdominal, Ventral, Leukemia         |                                                                          |             
          Mononuclear                      |                                                                      X   |             
      Head, Leukemia Mononuclear           |                                                                      X   |             
      Neck, Leukemia Mononuclear           |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                       X                  |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                             X            |             
      Leukemia Mononuclear                 |          X           X     X                    X              X  X  X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nerve, Leukemia Mononuclear          |                                                                      X   |             
      Sinus, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                    +     +              +        +  +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +     +              +     +        +   |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                             +            |             
      Carcinoma                            |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X     X   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X           X     X                    X              X  X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X  X                                X        X  X               |         12 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          4 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                              +              +            |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                         X  X               |          5 |
      Endocardium, Schwannoma Benign       |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                         X  X               |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |             X                                         X  X               |          4 |
      Pheochromocytoma Benign              |                                                    X                    X|          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |                      X        X     X     X                              |         13 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
      Bilateral, C-Cell, Adenoma           |                   X                                                      |          1 |
      C-Cell, Adenoma                      |                                                    X                     |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              | X                                                                        |          1 |
      Carcinoma                            |                                  X                                       |          1 |
      Leukemia Mononuclear                 |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                              X        X  X               |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X  X               |          3 |
      Polyp Stromal                        |             X  X              X     X           X                 X      |         12 |
      Endometrium, Adenoma                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                      +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Leukemia Mononuclear        |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Deep Cervical, Leukemia Mononuclear  |                                                       X                  |          1 |
      Inguinal, Leukemia Mononuclear       |                                              X                           |          1 |
      Mandibular, Leukemia Mononuclear     |       X  X  X                                X        X  X               |         13 |
      Mediastinal, Leukemia Mononuclear    |          X  X                                X        X  X               |         11 |
      Pancreatic, Leukemia Mononuclear     |                                              X        X                  |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                              +           +               |   4        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                              X           X               |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X  X  X                                X        X  X               |         12 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Leukemia Mononuclear                 |          X  X                                X        X  X               |          8 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibroadenoma                         |                   X                    X                                 |          4 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Papilloma              |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Abdominal, Ventral, Leukemia         |                                                                          |            |
          Mononuclear                      |                                                                          |          1 |
      Head, Leukemia Mononuclear           |                                                                          |          1 |
      Neck, Leukemia Mononuclear           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X  X                                X        X  X               |         13 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Nerve, Leukemia Mononuclear          |                                                                          |          1 |
      Sinus, Leukemia Mononuclear          |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                    +                                       |   8        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                +               |   7        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X  X                                X        X  X               |          7 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X  X  X                                X        X  X               |         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|             
                                           | 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Pheochromocytoma Benign              |    X                          X                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X        X                                X        X           X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                               X                                   X  X   |             
      Follicular Cell, Adenocarcinoma      |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|             
                                           | 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |       X  X                                            X              X   |             
      Sarcoma Stromal                      |                               X                                          |             
      Endometrium, Adenocarcinoma          |                                                                          |             
      Endometrium, Sarcoma Stromal         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                   +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Leukemia Mononuclear     |                                                       X              X   |             
      Mediastinal, Leukemia Mononuclear    |                                                       X              X   |             
      Pancreatic, Leukemia Mononuclear     |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                                       X              X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Spinal, Schwannoma Malignant         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|             
                                           | 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                      +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X              X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8|            |
                                           | 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X  X        X  X                       X           X         |          8 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   1        |
      Leukemia Mononuclear                 |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X              X                                   X         |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                      X                     |          3 |
      Pheochromocytoma Benign              |                               X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |                         X     X     X           X  X                 X  X|         13 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, C-Cell, Adenoma           |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8|            |
                                           | 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Adenoma                      |                                                                      X   |          4 |
      Follicular Cell, Adenocarcinoma      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Carcinoma                            |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Polyp Stromal                        |          X                                      X                        |          6 |
      Sarcoma Stromal                      |                                                                          |          1 |
      Endometrium, Adenocarcinoma          |                                  X                                       |          1 |
      Endometrium, Sarcoma Stromal         |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                     +                                    |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mandibular, Leukemia Mononuclear     |             X  X           X                       X           X         |          7 |
      Mediastinal, Leukemia Mononuclear    |             X  X                                   X                     |          5 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +  +                                               +         |   3        |
      Leukemia Mononuclear                 |             X  X                                               X         |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X  X        X  X                       X           X         |          8 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |             X  X                                   X                     |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibroadenoma                         |                                                                X  X      |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8|            |
                                           | 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                         +|   1        |
      Spinal, Schwannoma Malignant         |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X  X        X  X                       X           X         |          8 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                       +        +        +|   4        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                    +                                 |   4        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                                +                                    |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X  X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X  X        X  X                       X           X         |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|             
                                           | 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|             
      Leukemia Mononuclear                 |                                     X                 X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                             X            |             
      Leukemia Mononuclear                 | X     X              X           X  X  X        X     X           X  X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                        +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Squamous Cell Carcinoma              |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X              X           X  X                 X           X      |             
      Schwannoma Benign                    |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Capsule, Mesothelioma     |                                                                          |             
          Malignant                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|             
                                           | 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                  X  X  X              X           X  X  X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X  X                 X           X  X  X|             
      Pheochromocytoma Benign              |    X     X     X  X        X     X  X     X                              |             
      Bilateral, Pheochromocytoma Benign   | X                    X                       X                 X     X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X  X     X  X     X                    X  X                    X         |             
      Pars Nervosa, Histiocytic Sarcoma    |                                                             X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, C-Cell, Adenoma           |                      X     X                    X                        |             
      C-Cell, Adenoma                      |       X                       X  X                 X        X        X   |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenocarcinoma      |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Mesothelioma Malignant    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                         X                                                |             
      Carcinoma                            |                                                    X                     |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +                                         +                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|    X  X        X  X  X  X  X  X  X  X     X  X  X  X  X     X  X  X  X  X|             
      Bilateral, Tunic, Mesothelioma       |                                                                          |             
          Malignant                        |                                                                          |             
      Interstitial Cell, Adenoma           |          X  X                                            X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|             
                                           | 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Histiocytic Sarcoma         |                                                             X            |             
      Femoral, Leukemia Mononuclear        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Mandibular, Histiocytic Sarcoma      |                                                             X            |             
      Mandibular, Leukemia Mononuclear     | X     X                          X  X  X        X     X           X     X|             
      Mediastinal, Leukemia Mononuclear    | X     X              X              X  X        X     X           X      |             
      Pancreatic, Leukemia Mononuclear     |       X                                                                 X|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                             +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             +            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X     X              X           X  X  X        X     X           X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  M  M  +  +  +|             
      Leukemia Mononuclear                 |       X                          X  X  X        X     X           X  X  X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +                 +  +     +           +  +  +  +  +  +  +      |             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |                            X                             X               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                      X   |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Benign                   |                                                       X                  |             
      Histiocytic Sarcoma                  |                                                             X            |             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma                            |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|             
                                           | 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                             X            |             
      Leukemia Mononuclear                 | X     X              X           X  X  X        X     X           X  X  X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp                                |                                                                          |             
      Nares, Leukemia Mononuclear          |                                                                          |             
      Nasolacrimal Duct, Histiocytic       |                                                                          |             
          Sarcoma                          |                                                             X            |             
      Sinus, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +              +                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X              X           X  X  X        X     X              X  X|             
      Sarcoma                              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                             +            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                             X            |             
      Leukemia Mononuclear                 | X     X              X           X  X  X        X     X           X  X  X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Mesothelioma Malignant               |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                X     X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +  +|  46        |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X  X  X  X     X     X  X     X        X     X           X  X  X   |         25 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +              +                       +  +              +   |   7        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
      Mesothelioma Malignant               |                            X                          X                  |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X                       X                           |          3 |
      Mesothelioma Malignant               |                            X                          X                  |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X  X     X     X        X              X     X                 X   |         14 |
      Schwannoma Benign                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Capsule, Mesothelioma     |                                                                          |            |
          Malignant                        |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X  X  X  X     X     X  X     X              X                 X   |         18 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X     X  X  X     X     X  X     X              X                 X   |         16 |
      Pheochromocytoma Benign              |       X                             X     X              X              X|         13 |
      Bilateral, Pheochromocytoma Benign   |                                                 X                        |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |          X                          X        X                           |          3 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X     X     X                                                   |          3 |
      Pars Distalis, Adenoma               | X     X                          X     X        X     X                  |         14 |
      Pars Nervosa, Histiocytic Sarcoma    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
      Bilateral, C-Cell, Adenoma           |                                                                          |          3 |
      C-Cell, Adenoma                      |                                           X                       X      |          8 |
      C-Cell, Carcinoma                    | X                                                                        |          1 |
      Follicular Cell, Adenocarcinoma      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mesothelioma Malignant               |                                                       X                  |          1 |
      Bilateral, Mesothelioma Malignant    |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                      X   |          2 |
      Carcinoma                            |                                                             X            |          2 |
      Leukemia Mononuclear                 |             X        X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                      +   |   3        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X     X     X  X  X  X  X  X  X  X     X  X|         42 |
      Bilateral, Tunic, Mesothelioma       |                                                                          |            |
          Malignant                        |                            X                          X                  |          2 |
      Interstitial Cell, Adenoma           |                                                                   X      |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Histiocytic Sarcoma         |                                                                          |          1 |
      Femoral, Leukemia Mononuclear        |          X           X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Deep Cervical, Leukemia Mononuclear  |             X        X                                                   |          2 |
      Inguinal, Leukemia Mononuclear       |    X                                                                     |          1 |
      Lumbar, Leukemia Mononuclear         |                      X                                                   |          1 |
      Mandibular, Histiocytic Sarcoma      |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |    X     X  X  X     X     X  X     X        X     X              X  X   |         21 |
      Mediastinal, Leukemia Mononuclear    |    X  X  X  X  X     X     X  X              X     X                 X   |         19 |
      Pancreatic, Leukemia Mononuclear     |    X                       X        X                                    |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +                                   +  +        +                     |   5        |
      Leukemia Mononuclear                 |    X                                               X                     |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |    X  X  X  X  X     X     X  X     X        X     X           X  X  X   |         25 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M|  40        |
      Leukemia Mononuclear                 |    X     X     X           X  X     X        X     X                 X   |         18 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +           +     +     +  +     +  +           +           +  +     +|  23        |
      Adenocarcinoma                       |                            X                                             |          1 |
      Fibroadenoma                         |                                                                X         |          3 |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Keratoacanthoma                      |                               X                                          |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Squamous Cell Carcinoma              |                                        X                                 |          2 |
      Subcutaneous Tissue, Fibroma         |                         X                                                |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Benign                   |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |             X  X                                                         |          3 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                 X                        |          1 |
      Carcinoma                            |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X  X  X  X     X     X  X     X        X     X                 X   |         23 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Polyp                                |                                                                         X|          1 |
      Nares, Leukemia Mononuclear          |                      X                                                   |          1 |
      Nasolacrimal Duct, Histiocytic       |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
      Sinus, Leukemia Mononuclear          |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                +         |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +        +  +  +                          +           +        +         |   9        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                                               +   |   2        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X  X  X  X     X     X  X     X        X     X                 X   |         21 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
      Mesothelioma Malignant               |                                                       X                  |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X  X  X  X     X     X  X     X        X     X           X  X  X   |         25 |
      Mesothelioma Malignant               |                            X                          X                  |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|             
                                           | 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +           +  +  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +           +  A  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +           +  +  +     A     +  +  +     A     +              +  +  +  +|             
      Lymphoid Nodule, Leukemia Mononuclear|                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +           +  A  +     A     +  +  +     A     +              +  +  +  +|             
      Lymphoid Nodule, Leukemia Mononuclear|                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +           +  +  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +           +  +  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +  A  +     A     +  +  +     A     +              +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Peyer's Patch, Leukemia Mononuclear  |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +  A  +     A     +  +  +     A     +              +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               | X                                                                        |             
      Leukemia Mononuclear                 | X                 X     X  X     X  X           X  X                 X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +  +      |             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +           +  +  +     +     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +           +  +        +     +  +  +     A     +              +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +           +  A        +     +  +  +     A     +              +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +           +  +  +     +     +  +  +     +  +  +              +  +  +  +|             
      Leukemia Mononuclear                 | X                       X                       X                    X  X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X        X  X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X  X                                    |             
      Pheochromocytoma Malignant           |                X                                                         |             
      Pheochromocytoma Benign              |    X     X                 X                       X           X  X      |             
      Bilateral, Pheochromocytoma Benign   |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|             
                                           | 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +           +  +  +     +     +  +  +     +     +     +        +  +  +  +|             
      Pars Distalis, Adenoma               |             X                                                            |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +  A  +     A     +  +  +     A  +  +              +  +  +  +|             
      C-Cell, Adenoma                      |                   X           X     X           X                    X   |             
      C-Cell, Carcinoma                    |                                              X                           |             
      Follicular Cell, Adenocarcinoma      |          X                                                        X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +           +  +  +     +  +  +  +  +     +     +              +  M  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Adenoma                              |                               X                                          |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                         X           X                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                            +                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X   |             
      Interstitial Cell, Adenoma           |                                           X                             X|             
      Tunic, Mesothelioma Malignant        |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +           +  +  +     A     +  +  +     +     +              +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Lumbar, Leukemia Mononuclear         |                                     X                                    |             
      Mandibular, Leukemia Mononuclear     |                         X        X  X           X                    X  X|             
      Mediastinal, Leukemia Mononuclear    |                                  X  X           X                       X|             
      Pancreatic, Leukemia Mononuclear     |                                     X                                    |             
      Renal, Leukemia Mononuclear          |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                               +                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                         +     +  +                                +      |             
      Leukemia Mononuclear                 |                         X        X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +  +  +     +  +  +  +  +  +  +     +              +  +  +  +|             
      Leukemia Mononuclear                 | X                 X     X  X     X  X  X        X                    X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|             
                                           | 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Capsule, Mesothelioma Malignant      |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +           +  +  +     +     +  +  +     +     +              +  +  M  +|             
      Leukemia Mononuclear                 |                         X        X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +     +           +                 +                    +   |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Osteosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Astrocytoma Malignant                | X                                                                        |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |             
      Leukemia Mononuclear                 |                   X     X        X  X           X                    X  X|             
                                            __________________________________________________________________________|             
   Nose                                    | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X        X  X           X                    X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +           +  +  +     A     +  +  +     +     +              +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|             
                                           | 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 | X                 X     X  X     X  X  X        X  X                 X  X|             
      Mesothelioma Malignant               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6|            |
                                           | 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  25        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +        +  A  +              +     +     +  +  A        +  +  +|  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +        +  +  +              M     +     +  +  +        +  +  +|  24        |
      Lymphoid Nodule, Leukemia Mononuclear|                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +        +  +  +              +     +     +  +  +        +  +  +|  24        |
      Lymphoid Nodule, Leukemia Mononuclear|                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +        +  +  +              +     +     +  +  +        +  +  +|  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  +        +  A  +              +     +     +  +  A        +  +  +|  22        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Peyer's Patch, Leukemia Mononuclear  |                                                       X           X      |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +  +        +  +  +              +     +     +  +  +        +  +  +|  24        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Peyer's Patch, Leukemia Mononuclear  |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X  X     X  X  X  X              X           X  X  X        X  X   |         23 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                                          |   3        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +        +  +  +  +           +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +        +  +  +  +           +     +     +  +  +        +  +  +|  26        |
      Squamous Cell Papilloma              |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +        +  +  +  +           +     +     +  +  +        +  +  +|  25        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +        +  +  +              +     +     +  +  +        +  +  +|  28        |
      Leukemia Mononuclear                 |          X        X  X  X              X           X     X           X   |         13 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X        X  X                 X           X  X  X           X   |         11 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  67                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6|            |
                                           | 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X        X  X                             X  X              X   |          8 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |          X     X     X                       X                          X|         11 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Adenoma                              |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +        +  M  +              +     +     +  +  +        +  +  +|  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +  +  +  +     +        +  +  +     +  +  +  +     +  +  +|  34        |
      Pars Distalis, Adenoma               |             X  X              X        X  X  X     X  X     X            |         10 |
      Pars Distalis, Leukemia Mononuclear  |                   X     X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +        +  +  +              +     +     +  +  +        +  +  +|  26        |
      C-Cell, Adenoma                      |                      X                 X     X     X              X     X|         11 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenocarcinoma      |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                       X                  |          1 |
      Leukemia Mononuclear                 |       X  X           X                 X                 X               |          7 |
                                            __________________________________________________________________________|____________|
   Prostate                                |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X     X  X  X  X  X  X  X  X  X     X  X  X  X     X  X  X  X  X  X|         45 |
      Interstitial Cell, Adenoma           |          X                             X              X                  |          5 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +        +  +  +              +     +     +  +  +        +  +  +|  26        |
      Femoral, Leukemia Mononuclear        |                      X                                   X               |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Inguinal, Leukemia Mononuclear       |                                                       X                  |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  68                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6|            |
                                           | 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |       X  X        X  X  X              X           X  X  X        X  X   |         17 |
      Mediastinal, Leukemia Mononuclear    |       X  X        X  X                 X              X  X        X  X   |         13 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +                                         +                     |   7        |
      Leukemia Mononuclear                 |       X  X                                         X                     |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +     +  +  +  +              +     +     +  +  +  +     +  +  +|  33        |
      Leukemia Mononuclear                 | X     X  X     X  X  X  X              X           X  X  X  X     X  X   |         24 |
      Capsule, Mesothelioma Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  M        M  +  +              +     +     +  +  M        +  +  +|  23        |
      Leukemia Mononuclear                 |       X              X                                X                  |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +     +        +     +                    +     +  +                  |  12        |
      Fibroadenoma                         |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +     +  +  +  +              +     +     +  +  +        +  +  +|  29        |
      Keratoacanthoma                      |                                                                         X|          1 |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Squamous Cell Papilloma              |                X                                                         |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                         X|          1 |
      Subcutaneous Tissue, Osteosarcoma    | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |          X           X                 X                 X        X      |          5 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                              +                           |   1        |
      Schwannoma Malignant                 |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X        X  X  X              X           X  X  X        X  X   |         18 |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6|            |
                                           | 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                   +                              |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   1        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +        +  +  +  +           +     +     +  +  +        +  +  +|  28        |
      Leukemia Mononuclear                 |       X  X           X  X              X           X  X  X        X  X   |         16 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  26        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X  X     X  X  X  X              X           X  X  X  X     X  X   |         25 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|             
                                           | 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +           +        +  +  +        +           +        +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    A           +        +  +  +        A           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    A           +        +  +  +        A           +        +     +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    A           +        M  +  +        A           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    A           +        +  +  +        A           +        +     +  A  +|             
      Lymphoid Nodule, Leukemia Mononuclear|                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A           +        +  +  +        A           +        +     +  A  A|             
      Peyer's Patch, Leukemia Mononuclear  |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A           +        +  +  +        A           +        +     +  A  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                    X                     |             
      Hepatocellular Adenoma               |                X                                                         |             
      Hepatocellular Adenoma, Multiple     |                      X                                                   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |          X     X  X  X  X  X     X  X        X     X     X  X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +              +      |             
      Leukemia Mononuclear                 |                                                    X                     |             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    A  +        +        +  +  +        +           +        +     +  A  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    A           +        +  +  +        +           +        +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    A           +        +  +  +        +           +        +     +  A  +|             
      Serosa, Mesothelioma Malignant       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +           +        +  +  +        +           +        +     +  +  +|             
      Leukemia Mononuclear                 |                         X                          X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                          X                     |             
      Pheochromocytoma Malignant           |    X                                   X                                 |             
      Pheochromocytoma Benign              |             X  X  X     X           X                 X  X               |             
      Bilateral, Pheochromocytoma Benign   |          X                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +           +        +  +  +        +           +        +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|             
                                           | 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +     +        +  +  +        +        +  +     +  I     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                X           X                    X        X           X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  A           +        +  +  +        A           +        +     +  A  A|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      | X                       X  X                                      X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
      Chemodectoma Benign                  |                                                                          |             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +           +        +  +  +        +           +        +     +  +  +|             
      Bilateral, Mesothelioma Malignant    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +           +        +     +        +           +        +     +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                         X                                   X            |             
                                            __________________________________________________________________________|             
   Prostate                                |    +           +        +  +  +        +           +        +     +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X     X  X  X  X  X  X  X     X  X  X  X  X  X     X     X     X  X      |             
      Bilateral, Tunic, Mesothelioma       |                                                                          |             
          Malignant                        |                                                                   X      |             
      Interstitial Cell, Adenoma           |                            X                    X     X     X            |             
      Interstitial Cell, Carcinoma         |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +           +        +  +  +        +           +        +     +  A  +|             
      Femoral, Histiocytic Sarcoma         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +        +  +  +        +     +     +        +     +  +  +|             
      Inguinal, Leukemia Mononuclear       |                         X                                   X            |             
      Mandibular, Histiocytic Sarcoma      |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                X        X  X                 X     X        X            |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                X        X                                   X            |             
      Renal, Leukemia Mononuclear          |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                         +     +                                          |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  |    A           +  +  +  +  +  +  +  +  +  +  +     +        +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                X  X  X  X  X     X  X        X     X        X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|             
                                           | 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +           +        +  +  +        +           +        +     +  +  +|             
      Leukemia Mononuclear                 |                         X                          X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +           +                                         +   |             
      Fibroadenoma                         |                            X                                             |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +        +  +  +        +        +  +  +     +     M  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +     +        +  +  +        +           +        +     +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +           +        +  +  +        +           +        +     +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +           +        +  +  +        +           +        +     +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic                |                                                                      X   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                X        X  X                       X        X            |             
                                            __________________________________________________________________________|             
   Nose                                    |    +           +        +  +  +        +           +        +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +           +        +  +  +        +           +        +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
      Leukemia Mononuclear                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +           +        +  +  +        +           +        +     +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    A           +        +  +  +        +           +        +     +  A  +|             
      Leukemia Mononuclear                 |                         X                          X                     |             
      Mesothelioma Malignant               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |          X     X  X  X  X  X     X  X        X     X     X  X            |             
      Mesothelioma Malignant               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5|            |
                                           | 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +  +  +                                   +           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +           +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +  +  +                                   +           +  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +           +  +  +                                   +           +  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +  +  +                                   +           +  +|  14        |
      Lymphoid Nodule, Leukemia Mononuclear|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +  +  +                                   +           +  +|  13        |
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +  +  +                                   +           +  +|  13        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |          X     X           X  X  X                    X  X        X  X  X|         22 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   3        |
      Leukemia Mononuclear                 |                X                                                         |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +  +  +                                   +           +  +|  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +  +  +                                   +           +  +|  16        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +  +                                   +           +  +|  15        |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +           +  +  +                                   +           +  +|  18        |
      Leukemia Mononuclear                 |                X                                                     X   |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |          X     X           X                                         X   |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X     X           X                                             |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  74                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5|            |
                                           | 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              |             X                 X           X  X                           |         11 |
      Bilateral, Pheochromocytoma Benign   |                         X              X                 X     X         |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +  +  +                                   +           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +  +  +              +                    +           +  +|  20        |
      Leukemia Mononuclear                 |                X                                                         |          1 |
      Pars Distalis, Adenoma               |                                     X                                    |          6 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +  +                                   +           +  +|  14        |
      Bilateral, C-Cell, Adenoma           |                                                          X               |          1 |
      C-Cell, Adenoma                      |                   X                                                     X|          6 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                  +                                       |   2        |
      Chemodectoma Benign                  |                                  X                                       |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                +  +  +                                   +           +  +|  17        |
      Bilateral, Mesothelioma Malignant    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +  +  +           +                       +        +  +  +|  18        |
      Adenoma                              |                                  X                                       |          1 |
      Leukemia Mononuclear                 |                X                                                     X   |          4 |
                                            __________________________________________________________________________|____________|
   Prostate                                |                +  +  +                                   +           +  +|  17        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X|         42 |
      Bilateral, Tunic, Mesothelioma       |                                                                          |            |
          Malignant                        |                                                                          |          1 |
      Interstitial Cell, Adenoma           |                                                                      X   |          5 |
      Interstitial Cell, Carcinoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +  +  +                                   +           +  +|  16        |
      Femoral, Histiocytic Sarcoma         |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +     +  +  +                                   +           +  +|  19        |
      Inguinal, Leukemia Mononuclear       |                                                                          |          2 |
      Mandibular, Histiocytic Sarcoma      |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  75                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5|            |
                                           | 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mandibular, Leukemia Mononuclear     |          X     X                                                     X   |          9 |
      Mediastinal, Histiocytic Sarcoma     |                      X                                                   |          1 |
      Mediastinal, Leukemia Mononuclear    |                X                                                     X   |          5 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                      +                                   +               |   4        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +     +  +  +     +  +  +           +        +  +        +  +  +|  29        |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |          X     X           X  X  X                    X  X        X  X   |         19 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +  +  M                                   +           +  M|  15        |
      Leukemia Mononuclear                 |                X                                                     X   |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +  +                          +     +                 +   |   8        |
      Fibroadenoma                         |                   X                          X     X                     |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +                                +     +     +  +|  20        |
      Leukemia Mononuclear                 |                X                                                         |          1 |
      Subcutaneous Tissue, Fibroma         |                         X                                      X        X|          4 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +  +                                   +           +  +|  18        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +  +  +                                   +           +  +|  17        |
      Leukemia Mononuclear                 |                X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +  +  +                                   +  +        +  +|  18        |
      Alveolar/Bronchiolar Carcinoma       |                                                             X            |          1 |
      Carcinoma, Metastatic                |                                                                          |          1 |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |                X                                                     X   |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                +  +  +                                   +           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +  +  +                                   +           +  +|  17        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                    +     +  +                          +         |   6        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  76                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5|            |
                                           | 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +     +  +  +                                   +  +  +     +  +|  21        |
      Leukemia Mononuclear                 |          X     X                                                     X   |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +  +  +                                   +           +  +|  15        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |          X     X           X  X  X                    X  X        X  X  X|         22 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  77                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|             
                                           | 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     M  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +  +              +  +        +        +  +  +        A        +|             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +  +              +  +        +        +  +  +        A        +|             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +  +              +  +        +        +  +  +        A        +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                     X                                    |             
      Leukemia Mononuclear                 |    X  X                       X  X  X  X     X  X  X     X  X  X         |             
      Serosa, Mesothelioma Malignant       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +           +                     |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                        X           X                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +  +              +  +        +     +  +  +  +        A        +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Mesothelioma Malignant               |                                        X           X                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +  +              +  +        +        +  +  +        +        +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +  +              +  +        +  +     +  +  +        +        +|             
      Leukemia Mononuclear                 |    X                          X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Leukemia Mononuclear        |       X                                                                  |             
      Capsule, Mesothelioma Malignant      |                                        X           X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |    X                          X              X                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |    X                          X              X                           |             
      Pheochromocytoma Malignant           |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|             
                                           | 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              |                X     X           X           X        X  X        X  X  X|             
      Bilateral, Pheochromocytoma Benign   |                                           X                 X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +     +        +  +        +        +  +  +     +  +     +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
      Pars Distalis, Adenoma               |       X           X        X                                             |             
      Pars Intermedia, Adenoma             |                                                                         X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +  +              +  +        +        +  +  +        A        +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abdominal, Mesothelioma Malignant    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +     +  +              +  +        +        +  +  +        +        +|             
      Mesothelioma Malignant               |                                        X           X                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     M  +        +     +  +        +        +  +  +        +        +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |    X                          X        X           X                     |             
                                            __________________________________________________________________________|             
   Prostate                                |    +     +  +              +  +        +        +  +  +        +        +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X     X  X|             
      Bilateral, Tunic, Mesothelioma       |                                                                          |             
          Malignant                        |                                        X           X                     |             
      Interstitial Cell, Adenoma           |                                  X                                X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +              +  +        +        +  +  +        A        +|             
      Femoral, Leukemia Mononuclear        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +              +  +        +        +  +  +        +        +|             
      Deep Cervical, Leukemia Mononuclear  |    X                                                                     |             
      Mandibular, Leukemia Mononuclear     |    X                          X        X        X  X                     |             
      Mediastinal, Leukemia Mononuclear    |    X                          X        X                                 |             
      Mediastinal, Mesothelioma Malignant  |                                        X                                 |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                        +                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                        +                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +              +  +  +  +  +        +  +  +  +  +  +        +|             
      Leukemia Mononuclear                 |    X                       X  X  X  X  X        X  X     X  X  X        X|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +              +  +        +        +  +  +        +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|             
                                           | 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |    X                          X        X                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +        +                 +                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +           +  +  +     +        +  +  +  +     +        +|             
      Basal Cell Adenoma                   |                                                          X               |             
      Keratoacanthoma                      |                X                                                         |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                            X                                             |             
      Subcutaneous Tissue, Fibrosarcoma    |          X  X                                                            |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +              +  +        +        +  +  +        +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +  +              +  +        +        +  +  +        +        +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +  +              +  +        +        +  +  +        +        +|             
      Leukemia Mononuclear                 |    X                          X        X        X  X                     |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +  +              +  +        +  +     +  +  +        +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                            +                        |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                               |             
      Carcinoma                            |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +  +              +  +        +  +  +  +  +  +  +     +        +|             
      Leukemia Mononuclear                 |    X                       X  X        X     X  X  X     X               |             
      Capsule, Mesothelioma Malignant      |                                                    X                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +  +              +  +        +        +  +  +        A        +|             
      Mesothelioma Malignant               |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                    X  X  X  X  X     X  X  X     X  X  X        X|             
      Mesothelioma Malignant               |                                        X           X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4|            |
                                           | 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                               X                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 | X        X  X  X           X  X  X                 X  X     X            |         22 |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   3        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +  +                    +  +     +  +     +  +        +  +  +   |  23        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                  +                                       |   1        |
      Squamous Cell Papilloma              |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  25        |
      Leukemia Mononuclear                 |             X                                      X                     |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Leukemia Mononuclear        |                                                                          |          1 |
      Capsule, Mesothelioma Malignant      |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  81                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4|            |
                                           | 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |             X  X                                                         |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |             X  X                                                         |          5 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |       X           X     X     X           X  X  X     X  X  X            |         19 |
      Bilateral, Pheochromocytoma Benign   |    X                             X                 X                 X  X|          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +  +  +                 +  +     +  +     +  +  +  +  +  +  +  +|  31        |
      Leukemia Mononuclear                 |             X  X                                                         |          3 |
      Pars Distalis, Adenoma               |                                                       X     X  X  X     X|          8 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | A        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
      Bilateral, C-Cell, Adenoma           |                                                                   X      |          1 |
      C-Cell, Adenoma                      |          X                          X                    X     X         |          5 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                          +               |   1        |
      Abdominal, Mesothelioma Malignant    |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Adenoma                              |                                           X              X               |          2 |
      Leukemia Mononuclear                 |          X  X                                      X                     |          7 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |  48        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X     X  X  X     X  X  X  X  X  X  X  X     X  X      |         43 |
      Bilateral, Tunic, Mesothelioma       |                                                                          |            |
          Malignant                        |                                                                          |          2 |
      Interstitial Cell, Adenoma           |                      X           X                                   X   |          5 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
      Femoral, Leukemia Mononuclear        |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +                 +  +     +  +     +  +  +     +  +  +   |  26        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  82                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4|            |
                                           | 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     | X        X  X  X                 X                 X  X                  |         12 |
      Mediastinal, Leukemia Mononuclear    | X           X                    X                 X                     |          7 |
      Mediastinal, Mesothelioma Malignant  |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                           +  +                           |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +                             +        +  +                           |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +  +              +  +  +     +  +     +  +  +  +  +  +  +   |  31        |
      Leukemia Mononuclear                 | X        X  X  X              X  X                 X  X     X            |         21 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +        +  +                    +  +     +  +     +  +  +     M  +  +   |  23        |
      Leukemia Mononuclear                 |          X  X                                      X                     |          6 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +                                +        +           +      |   7        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +  +     +     +  +     +  +     +  +     +  +  +     +  +  +   |  31        |
      Basal Cell Adenoma                   |                                              X                           |          2 |
      Keratoacanthoma                      |                   X                          X                           |          3 |
      Squamous Cell Papilloma              |                         X  X                                             |          2 |
      Subcutaneous Tissue, Fibroma         |                                                                      X   |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          2 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  25        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Leukemia Mononuclear                 | X        X  X                    X                 X  X                  |         11 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  25        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                       +|   4        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  83                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4|            |
                                           | 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +  +                    +  +     +  +  +  +  +  +     +  +  +   |  28        |
      Leukemia Mononuclear                 | X        X  X                    X                 X                     |         13 |
      Capsule, Mesothelioma Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X        X  X  X           X  X  X                 X  X     X            |         24 |
      Mesothelioma Malignant               |                                                          X               |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  84                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|             
                                           | 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X        X        X  X        X  X     X              X            |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                 +           +                          +               |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  A     +  +     +           +     +     +        +  +  A  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  M     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                        +              +                  |             
      Squamous Cell Papilloma              |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
      Leukemia Mononuclear                 |                         X           X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|             
                                           | 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Capsule, Leukemia Mononuclear        |                                                             X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Leukemia Mononuclear                 |       X                             X  X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Leukemia Mononuclear                 |       X                             X  X                                 |             
      Pheochromocytoma Malignant           |                            X                                             |             
      Pheochromocytoma Benign              |       X                             X                                    |             
      Bilateral, Pheochromocytoma Benign   |          X                                X        X                 X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  M     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |          X              X                       X                       X|             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  M     +  +     +  +  +     +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                     X                                    |             
      C-Cell, Carcinoma                    |                            X  X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +     +  +     +           +     +     +        M  +  A  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +     +  +     +           +     +  +  +     +  +  +  +  +     +|             
      Adenoma                              |                                              X                           |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                   X     X           X                       X            |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                   X                                         X            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X        X  X  X  X  X  X  X  X     X  X  X|             
      Bilateral, Tunic, Mesothelioma       |                                                                          |             
          Malignant                        |                                                          X               |             
      Interstitial Cell, Adenoma           |                                  X  X                          X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +     +  +     +           +     +     +        +  +  A  +     +|             
      Femoral, Histiocytic Sarcoma         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  M     +  +     +           +     +     +        +  +  A  +     +|             
      Inguinal, Leukemia Mononuclear       |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|             
                                           | 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mandibular, Histiocytic Sarcoma      |                                                                          |             
      Mandibular, Leukemia Mononuclear     |       X        X  X     X           X                       X            |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |       X           X     X           X                       X            |             
      Pancreatic, Leukemia Mononuclear     |                                                             X            |             
      Renal, Leukemia Mononuclear          |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +        +        +                                +               |             
      Leukemia Mononuclear                 |       X        X        X                                                |             
      Mediastinal, Mesothelioma Malignant, |                                                                          |             
           Metastatic, Mesentery           |                                                          X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +     +           +  +  +  +  +        +  +  A  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X        X        X           X  X     X              X        X   |             
      Capsule, Mesothelioma Malignant      |                                                          X               |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                   X     X           X                       X            |             
      Thymoma Benign                       |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +           +  +                 +           +           +           +|             
      Fibroadenoma                         |                                                                          |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
      Keratoacanthoma                      |                                           X                              |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Subcutaneous Tissue, Fibroma         |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
      Osteosarcoma                         |                                                                          |             
      Vertebra, Osteosarcoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
      Abdominal, Leukemia Mononuclear      |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +     +  +     +           +     +  +  +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|             
                                           | 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X        X  X     X           X        X              X            |             
      Osteosarcoma, Metastatic             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             
      Adenoma                              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +     +  +     +     +     +     +     +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |       X        X  X     X           X                       X            |             
      Transitional Epithelium, Carcinoma   |                                                                X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
      Mesothelioma Malignant               |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X        X  X     X  X        X  X     X              X        X   |             
      Mesothelioma Malignant               |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Leukemia Mononuclear                 |                      X                                   X               |          3 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocellular Adenoma               |       X                                                                  |          1 |
      Hepatocellular Adenoma, Multiple     |                                                                         X|          1 |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Leukemia Mononuclear                 |    X  X        X     X  X                 X           X  X     X  X  X  X|         20 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                 +                                   +               |   7        |
      Leukemia Mononuclear                 |    X                 X                                   X               |          4 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  89                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
      Leukemia Mononuclear                 |                                                          X        X      |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Capsule, Leukemia Mononuclear        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  47        |
      Leukemia Mononuclear                 |    X           X     X                                X  X        X      |          9 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |    X           X     X                                X  X        X      |          9 |
      Pheochromocytoma Malignant           |                                           X                              |          2 |
      Pheochromocytoma Benign              |       X           X                                                      |          4 |
      Bilateral, Pheochromocytoma Benign   |                      X                                         X        X|          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +        +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
      Carcinoma                            |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +              +  +  +  +        +  +  +  +  +     +  M        +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +              +  +  +  +     +  +  +  +  +  +     +  +  +     +  +   |  30        |
      Leukemia Mononuclear                 |                                                                   X      |          1 |
      Pars Distalis, Adenoma               | X                                X  X  X              X     X            |         10 |
      Pars Distalis, Leukemia Mononuclear  |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +              +  +  +  A        +  +  +  +  +     +  +        +  A   |  27        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      C-Cell, Adenoma                      |                         X              X              X  X               |          5 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +        +     +  +  +  +        +  +  +  +  +     +  +     +  +  +   |  33        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                X         |          1 |
      Leukemia Mononuclear                 |    X                 X                                   X        X  X   |          9 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
      Leukemia Mononuclear                 |                                                          X               |          3 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  90                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X     X  X  X  X  X     X  X  X  X  X  X  X  X           X|         42 |
      Bilateral, Tunic, Mesothelioma       |                                                                          |            |
          Malignant                        |                                                                          |          1 |
      Interstitial Cell, Adenoma           |                   X                 X                          X  X  X   |          8 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
      Femoral, Histiocytic Sarcoma         |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +              +  +  +  +     +  +  +  +  +  +     +  +     +  +  +   |  29        |
      Inguinal, Leukemia Mononuclear       |                                                                   X      |          2 |
      Mandibular, Histiocytic Sarcoma      |                                                 X                        |          1 |
      Mandibular, Leukemia Mononuclear     |    X                 X  X                 X           X  X        X  X   |         14 |
      Mediastinal, Histiocytic Sarcoma     |                                                 X                        |          1 |
      Mediastinal, Leukemia Mononuclear    |    X                 X  X                 X              X     X  X  X   |         13 |
      Pancreatic, Leukemia Mononuclear     |                                                          X               |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +  +                          +        +               |   8        |
      Leukemia Mononuclear                 |                      X                                   X               |          5 |
      Mediastinal, Mesothelioma Malignant, |                                                                          |            |
           Metastatic, Mesentery           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +  +  +        +  +  +  +  +     +  +     +  +  +   |  35        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Leukemia Mononuclear                 |    X  X        X     X  X                 X           X  X     X  X  X   |         19 |
      Capsule, Mesothelioma Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
      Leukemia Mononuclear                 |    X                 X                    X              X        X      |          9 |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                   +  +        +  +  +  +               |  14        |
      Fibroadenoma                         |                                                    X                     |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
      Keratoacanthoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  91                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
      Osteosarcoma                         |                            X                                             |          1 |
      Vertebra, Osteosarcoma               |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Abdominal, Leukemia Mononuclear      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
      Leukemia Mononuclear                 |    X                 X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                               +                                          |   1        |
      Schwannoma Malignant                 |                               X                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  30        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Leukemia Mononuclear                 |    X                 X  X                 X           X  X        X  X   |         15 |
      Osteosarcoma, Metastatic             |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +  +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  31        |
      Leukemia Mononuclear                 |    X                 X  X                 X              X        X      |         12 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Leukemia Mononuclear                 |    X  X        X     X  X                 X           X  X     X  X  X  X|         22 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  92                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  93                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|             
                                           | 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  A  A  +        +  +        +     A  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +  A  +        +  +        +     A  +  +  +     +  +  +     +|             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  A  A  +        +  +        +     A  +  +  +     +  +  +  +  +|             
      Peyer's Patch, Leukemia Mononuclear  |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +  A  +        +  +        +     A  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 | X                          X                                X  X  X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                X  X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                X            |             
      Pheochromocytoma Malignant           |                                           X  X                           |             
      Pheochromocytoma Benign              |       X        X  X     X  X     X  X  X                 X  X     X  X   |             
      Bilateral, Pheochromocytoma Benign   |                      X                                X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
      Adenoma                              |                            X                                             |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|             
                                           | 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  A  A  +        +  +        +     A  +  +  +     +  +  +     +|             
      Bilateral, C-Cell, Adenoma           |                               X                                          |             
      C-Cell, Adenoma                      |                                                 X              X         |             
      C-Cell, Carcinoma                    |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               | X                                      X                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Carcinoma                            |                               X                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X|             
      Bilateral, Tunic, Mesothelioma       |                                                                          |             
          Malignant                        |                                        X                                 |             
      Interstitial Cell, Adenoma           |                                        X                                 |             
      Tunic, Mesothelioma Malignant        | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  A  +        +  +        +        +  +  +  +  +  +  +  +  +|             
      Mandibular, Leukemia Mononuclear     |                            X                                X     X      |             
      Mediastinal, Leukemia Mononuclear    |                            X                                X     X      |             
      Pancreatic, Leukemia Mononuclear     |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                               +                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +                                      +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Hemangiosarcoma                      |                                                    X                     |             
      Leukemia Mononuclear                 | X                          X                                X  X  X      |             
      Sarcoma                              |                                                                          |             
      Capsule, Mesothelioma Malignant      |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +  +  +        +  +        +     +  M  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|             
                                           | 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +                    +                 +                           |             
      Fibroadenoma                         |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |                            X                                X  X  X      |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                              X                           |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +        +               |             
      Pinna, Basosquamous Tumor Benign     |                                                          X               |             
      Pinna, Fibrosarcoma                  |                                                 X                        |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                  +               |             
      Squamous Cell Carcinoma              |                                                          X               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +  +        +  +        +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                X     X      |             
      Transitional Epithelium, Carcinoma   |                               X                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  M  A  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                          X                                X  X  X      |             
      Mesothelioma Malignant               | X                                      X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4|            |
                                           | 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +     +  +  +  +              +     +        +     +     +  +      |  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  21        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  23        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  22        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    A  +     +  +  +  A           A  +     A        +     +     +  +      |  23        |
      Peyer's Patch, Leukemia Mononuclear  |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    A  +        +  +  A           A  +     A        +     +     +  +      |  22        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocellular Adenoma               |                                                             X            |          1 |
      Leukemia Mononuclear                 |                X  X                                               X  X   |          9 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   2        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  25        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  28        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    A  +     +  +  +  +           A  +     +        +     +     +  +      |  26        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    A  +     +  +  +  +           A  +     +        +     +     +  +      |  26        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  23        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Leukemia Mononuclear                 |                X  X                                               X      |          6 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                   X                                               X      |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                   X                                               X      |          4 |
      Pheochromocytoma Malignant           |       X        X                                                         |          4 |
      Pheochromocytoma Benign              |                X                    X        X                    X      |         16 |
      Bilateral, Pheochromocytoma Benign   |                               X                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  97                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4|            |
                                           | 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  25        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    M  +     +  +  +  +           +  +     +        +     +     M  +     +|  27        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
      Pars Distalis, Adenoma               |             X                                      X     X              X|          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    A  +     +  +  +  A              +     +        +     +     +  +      |  23        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |                                           X        X     X               |          5 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  30        |
      Leukemia Mononuclear                 |                X                                                         |          1 |
      Mesothelioma Malignant               |                                  X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                X  X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X  X  X  X        X  X  X  X  X     X     X        X  X|         41 |
      Bilateral, Tunic, Mesothelioma       |                                                                          |            |
          Malignant                        |                                  X                                       |          2 |
      Interstitial Cell, Adenoma           |                               X                    X     X        X      |          5 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Mandibular, Leukemia Mononuclear     |                X  X                                                      |          5 |
      Mediastinal, Leukemia Mononuclear    |                X  X                                                      |          5 |
      Pancreatic, Leukemia Mononuclear     |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                          +               |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                      +               |   4        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  98                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4|            |
                                           | 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    A  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                X  X                                               X      |          8 |
      Sarcoma                              |                                  X                                       |          1 |
      Capsule, Mesothelioma Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +     +  +  +  +              +     M        +     M     +  +      |  25        |
      Leukemia Mononuclear                 |                X  X                                                      |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +     +                                +     +               |   7        |
      Fibroadenoma                         |                                                          X               |          1 |
      Sarcoma                              |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +     +  +  +  +           +  +     +        +  +  +     +  +      |  30        |
      Keratoacanthoma                      |                                                    X                     |          1 |
      Squamous Cell Carcinoma              |                                                       X                  |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +        +  +  +  +           +  +     +        +     +     +  +      |  27        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Alveolar/Bronchiolar Adenoma         |                                           X                              |          1 |
      Leukemia Mononuclear                 |                X  X                                               X      |          7 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +     +  +     +           +  +     +        +     +     +  +      |  28        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +                                             |   3        |
      Pinna, Basosquamous Tumor Benign     |                                                                          |          1 |
      Pinna, Fibrosarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                          +                       +     +            |   6        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  99                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4|            |
                                           | 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                +                    +                                    |   2        |
      Carcinoma                            |                X                    X                                    |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    A  +     +  +  +  +           +  +     +        +     +     +  +      |  30        |
      Leukemia Mononuclear                 |                X  X                                               X      |          6 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  24        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                X  X                                               X  X   |          9 |
      Mesothelioma Malignant               |                                  X                                       |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 100                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|             
                                           | 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                              X                           |             
      Hepatocellular Adenoma, Multiple     |                                                    X                     |             
      Leukemia Mononuclear                 | X  X  X                                            X        X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                      +            |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                        X            |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                                         |             
      Molar, Adamantinoma Benign           |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic                |                   X                                                      |             
      Leukemia Mononuclear                 |       X                                                     X            |             
      Ventricle Left, Schwannoma Benign    |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Capsule, Leukemia Mononuclear        |    X                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|             
                                           | 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                   X                                                      |             
      Leukemia Mononuclear                 | X                                                           X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 | X                                                           X            |             
      Pheochromocytoma Benign              |    X  X  X     X  X           X        X     X                 X  X     X|             
      Bilateral, Pheochromocytoma Benign   |                         X        X                       X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                X     X        X                    X           X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                     X            |             
      C-Cell, Adenoma                      |       X                          X                 X     X     X         |             
      C-Cell, Carcinoma                    |                   X                                                      |             
      Follicular Cell, Adenocarcinoma      |                                                                          |             
      Follicular Cell, Adenoma             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Bilateral, Mesothelioma Malignant    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                     X            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                     X            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X     X  X  X  X  X  X     X  X  X  X  X     X  X  X  X|             
      Interstitial Cell, Adenoma           |                                                             X            |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deep Cervical, Leukemia Mononuclear  |       X                                                                  |             
      Deep Cervical, Mediastinal,          |                                                                          |             
          Mandibular, Carcinoma,           |                                                                          |             
          Metastatic, Thyroid Gland        |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|             
                                           | 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                             X            |             
      Mandibular, Carcinoma, Metastatic,   |                                                                          |             
           Skin                            |                                                                          |             
      Mandibular, Leukemia Mononuclear     | X  X  X                                                     X            |             
      Mediastinal, Leukemia Mononuclear    |    X  X                                            X        X            |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +           +     +                                   +            |             
      Leukemia Mononuclear                 |    X  X                                                     X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X                                            X        X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  M  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  M  M  M  +  M|             
      Leukemia Mononuclear                 | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +           +  +  +     +                                   +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |    X                                                        X            |             
      Squamous Cell Carcinoma              |                                                          X               |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Left, Femur, Osteosarcoma            |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
      Abdominal, Leukemia Mononuclear      |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                   X                                                      |             
      Leukemia Mononuclear                 | X  X  X                                            X        X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lamina Propria, Carcinoma,           |                                                                          |             
          Metastatic, Thyroid Gland        |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|             
                                           | 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                             +                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +     +           +                        |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X                                                     X            |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X                                            X        X            |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3|            |
                                           | 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  47        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  A|  46        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  47        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  48        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  47        |
      Leukemia Mononuclear                 |                                                       X                  |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  48        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma               |                   X                                         X            |          3 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Leukemia Mononuclear                 |          X        X     X     X     X  X     X  X  X  X  X        X  X  X|         19 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +  +     +     +      |   6        |
      Leukemia Mononuclear                 |                                                    X  X           X      |          4 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A|  48        |
      Leukemia Mononuclear                 |          X              X                          X                     |          5 |
      Mesothelioma Malignant               |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Leukemia Mononuclear                 |                                                 X     X                  |          4 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Leukemia Mononuclear                 |                                                       X           X      |          4 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Molar, Adamantinoma Benign           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic                |                                                                          |          1 |
      Leukemia Mononuclear                 |          X        X     X     X                 X  X  X  X        X  X  X|         13 |
      Ventricle Left, Schwannoma Benign    |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 105                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3|            |
                                           | 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Leukemia Mononuclear        |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |          X        X     X           X              X              X      |          8 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |          X        X                 X              X  X           X      |          8 |
      Pheochromocytoma Benign              |                X  X                       X                       X  X   |         16 |
      Bilateral, Pheochromocytoma Benign   |    X  X                             X              X  X     X            |          9 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Adenoma               |    X                       X                 X                    X  X   |         10 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  48        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      C-Cell, Adenoma                      |                X                       X              X     X     X      |         10 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenocarcinoma      |                                                             X            |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   1        |
      Carcinoma                            |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
      Bilateral, Mesothelioma Malignant    |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |          X                                   X     X  X              X  X|          9 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                     X                 X              X   |          6 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X        X  X  X  X  X  X     X  X     X  X  X  X     X  X        X|         40 |
      Interstitial Cell, Adenoma           |          X  X                             X              X        X      |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 106                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3|            |
                                           | 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Tunic, Mesothelioma Malignant        |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Femoral, Leukemia Mononuclear        |          X              X                             X                  |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Deep Cervical, Mediastinal,          |                                                                          |            |
          Mandibular, Carcinoma,           |                                                                          |            |
          Metastatic, Thyroid Gland        |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Mandibular, Carcinoma, Metastatic,   |                                                                          |            |
           Skin                            |                      X                                                   |          1 |
      Mandibular, Leukemia Mononuclear     |          X        X     X     X     X  X     X  X  X  X  X        X  X  X|         18 |
      Mediastinal, Leukemia Mononuclear    |          X              X                    X  X  X  X  X        X  X  X|         14 |
      Pancreatic, Leukemia Mononuclear     |          X                                   X        X                  |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +           +                          +                        |   8        |
      Leukemia Mononuclear                 |          X                                      X                        |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X        X     X     X     X  X     X  X  X  X  X        X  X  X|         19 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  35        |
      Leukemia Mononuclear                 |          X        X     X           X  X        X  X  X  X        X  X  X|         13 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +           +     +        +  +  +        +           +  +   |  19        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibroma                              |                                                                X         |          1 |
      Keratoacanthoma                      |                                                       X                  |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |