National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2141

TDMS Study 05075-01 Pathology Tables

NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97
Route: DOSED FEED                                                                                                 Time: 07:20:16




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57-41-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|             
                                           | 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Chronic Active, Focal  |                                                                          |             
      Ulcer                                |                                                                          |             
      Submucosa, Edema                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X        X  X  X  X  X  X  X     X  X  X  X  X     X|             
      Clear Cell Focus                     |                                                                          |             
      Fatty Change                         |    1                       4                       3           4         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Regeneration, Focal                  |                                                                          |             
      Sinusoid, Angiectasis                |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                              +         |             
      Inflammation, Chronic                | 3                                                                        |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Fat, Necrosis                        | 4                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2        3     2  2     3  2           1           1  2           1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Parotid Gland, Atrophy       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Submucosa, Edema                     |                            2                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Inflammation, Chronic, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Myocardium, Degeneration, Multifocal |          2  2     1  2  1     1     3     2  1  2     3     2     2      |             
      Myocardium, Fibrosis, Focal          |                                                                         2|             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|             
                                           | 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
           Multifocal                      | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular, Focal               |                                                                          |             
      Congestion                           |                                                 4                        |             
      Hyperplasia, Nodular                 | 2           1        2  4     1     1              2        3     2      |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 | 2              1        1                             1                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Nodular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  | X           X                                                            |             
      Pars Distalis, Hyperplasia, Nodular  |                                        1        2                       2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 4  2  2  2     2  2  2  4  2           2  4     3  3  2        4  3  2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Hyperplasia                          |                                     2                                    |             
      Inflammation, Chronic                |                   1                 1     1  1                           |             
      Inflammation, Chronic Active         |       2     3                                                            |             
      Duct, Dilatation                     |             3                                                            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             1                 2     2                                   1|             
      Corpus Luteum, Congestion            |                                                 3                        |             
      Follicle, Cyst                       |                                  X                                       |             
      Periovarian Tissue, Cyst             |                               X  X              X     X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prolapse                             |                                        X           X                 X   |             
      Endometrium, Bacterium               |                                        X                                 |             
      Endometrium, Hyperplasia, Cystic     |                   1           1                    2                     |             
      Endometrium, Necrosis, Coagulative   |                                                                          |             
      Wall, Inflammation, Chronic Active   |                                                    3                 3   |             
      Wall, Inflammation, Necrotizing      |                                        4                                 |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                        +                                 |             
      Lamina Propria, Inflammation,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|             
                                           | 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Necrotizing                      |                                                                          |             
      Wall, Edema                          |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Polychromasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Angiectasis                 |                                                 4                        |             
      Femoral, Hyperplasia                 |                            2           2           1                     |             
      Femoral, Hyperplasia, Re Cell        |                                     4                                    |             
      Femoral, Hypoplasia                  |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                +         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma, Single                    |                   1                                                      |             
      Hematopoietic Cell Proliferation     |                                     3  3        2                        |             
      Necrosis, Coagulative                |                                                                2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Arteriole, Inflammation, Chronic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                1        2  2  3  3  2  1  3        2  1  1  2  2     3   |             
      Duct, Inflammation, Chronic Active   |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                       4                  |             
      Hyperkeratosis                       |                                                       4                  |             
      Inflammation, Chronic                |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                         3                                                |             
      Femur, Osteopetrosis                 |                                                 2                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                            +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |    4           3        1  3     3  2              2     2  2  3     3   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          4               |             
      Alveolar Epithelium, Hyperplasia     |                                              2                           |             
      Bronchus, Foreign Body               |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|             
                                           | 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                                                       1                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lamina Propria, Inflammation, Chronic|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                          +     +         |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                    +  +                                             |             
      Lens Crystalline, Cataract           |                         4  3                                             |             
      Lids, Inflammation, Suppurative      |    1                                                                     |             
      Retina, Atrophy                      |                         4  3                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
      Inflammation, Chronic, Multifocal    | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Multifocal, Necrotizing|                                                                          |             
      Nephropathy, Multifocal              | 1  2  1  1     3  1     2  1  2  1              1     1  1  1  1        1|             
      Pelvis, Renal Tubule, Bacterium      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Diffuse                         |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3|            |
                                           | 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active, Focal  |    3                                                                     |      1  3.0|
      Ulcer                                |                                                             4            |      1  4.0|
      Submucosa, Edema                     |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                               X                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X     X  1     X     X  X  X  X  X  X  X        X  X     X  X  X  X|     40  1.0|
      Clear Cell Focus                     |       X                                                                  |      1     |
      Fatty Change                         |                                        1                                 |      5  2.6|
      Mixed Cell Focus                     |       X                                                                  |      1     |
      Necrosis, Coagulative, Multifocal    |                   2                                                      |      1  2.0|
      Regeneration, Focal                  |                   2                                2                     |      2  2.0|
      Sinusoid, Angiectasis                |                2                             2                          1|      3  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   3        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |    2                                                                     |      1  2.0|
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      | 1     2           1  2     1                       3     2     1  1  1  1|     21  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Parotid Gland, Atrophy       |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Submucosa, Edema                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                                     |   1        |
      Aorta, Inflammation, Chronic, Focal  |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3|            |
                                           | 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |    3                                                                     |      1  3.0|
      Myocardium, Degeneration, Multifocal | 2  2  1     2  2  2  1     1  2  1  1  1  2  1        1  1        1  1  1|     32  1.6|
      Myocardium, Fibrosis, Focal          |                                                                          |      1  2.0|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                        1                                 |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular, Focal               |                      1                                                   |      1  1.0|
      Congestion                           |                                                                          |      1  4.0|
      Hyperplasia, Nodular                 |       1        1  1     1  1              2        2     1     1        1|     19  1.6|
      Hypertrophy, Focal                   |                                        2                       2        1|      3  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Nodular                 |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia, Diffuse                 |                                                             3            |      1  3.0|
      Hyperplasia, Nodular                 |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                                          X               |      3     |
      Pars Distalis, Hyperplasia, Nodular  |    2                                                                     |      4  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  | 2  2        2     4  2  2  2  3     2  2     3           3  1     2  1   |     33  2.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |                      3                                                   |      2  2.5|
      Inflammation, Chronic                |    1                                                                 1   |      6  1.0|
      Inflammation, Chronic Active         |                            2                                             |      3  2.3|
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                | 1                                                                        |      5  1.4|
      Corpus Luteum, Congestion            |                                                                          |      1  3.0|
      Follicle, Cyst                       |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3|            |
                                           | 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Periovarian Tissue, Cyst             |                   X                                                      |      5     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Prolapse                             |                                                                          |      3     |
      Endometrium, Bacterium               |                                                                          |      1     |
      Endometrium, Hyperplasia, Cystic     |    1  1                    2  2           2                             2|      9  1.6|
      Endometrium, Necrosis, Coagulative   |             4                                                            |      1  4.0|
      Wall, Inflammation, Chronic Active   |                                                                          |      2  3.0|
      Wall, Inflammation, Necrotizing      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |          +                                                               |   2        |
      Lamina Propria, Inflammation,        |                                                                          |            |
          Necrotizing                      |          4                                                               |      1  4.0|
      Wall, Edema                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                    +                     |   1        |
      Polychromasia                        |                                                    X                     |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Angiectasis                 |                                                                          |      1  4.0|
      Femoral, Hyperplasia                 |                               2                 3  2           1         |      7  1.9|
      Femoral, Hyperplasia, Re Cell        |                                                                          |      1  4.0|
      Femoral, Hypoplasia                  |       4                                                                  |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma, Single                    |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.7|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Arteriole, Inflammation, Chronic     |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 1     1     3  3  3     3  1  2  2        2  3     1  1  3     3  1  2  1|     32  2.0|
      Duct, Inflammation, Chronic Active   |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  4.0|
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3|            |
                                           | 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                                                          |      1  3.0|
      Femur, Osteopetrosis                 |       3                                                                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypothalamus, Compression            |                         4  3                 4     2                     |     15  2.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Bronchus, Foreign Body               |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                      1                             1                     |      3  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lamina Propria, Inflammation, Chronic|                                           1                              |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +                                                               |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +  +                    +     +                    +              +|   9        |
      Lens Crystalline, Cataract           |       3                       4     1                    3              4|      7  3.1|
      Lids, Inflammation, Suppurative      |                                                                          |      1  1.0|
      Retina, Atrophy                      |       4                       4     3                    4              4|      7  3.7|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                 +                                             |   3        |
      Inflammation, Chronic, Multifocal    |                            2                                             |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                             4            |      1  4.0|
      Inflammation, Multifocal, Necrotizing|          3                                                               |      1  3.0|
      Nephropathy, Multifocal              | 1  1  1     2  2     1        1  2  1  2  3  3     2           1  1     1|     32  1.4|
      Pelvis, Renal Tubule, Bacterium      |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Hemorrhage                    |          3                                                               |      1  3.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Diffuse                         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|             
                                           | 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X        X  X  X  X  X  X     X  X  X     X  X  X        X  X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |             X                                                            |             
      Fatty Change                         |                         3                                                |             
      Granuloma, Multiple                  |                   2                                                      |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                                  1                    1                  |             
      Necrosis, Caseous                    |                                  1                                       |             
      Regeneration, Focal                  |                                                                          |             
      Sinusoid, Angiectasis                |                                                                1         |             
      Sinusoid, Angiectasis, Multifocal    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Acinus, Atrophy                      |                                  1        2                 1        1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Inflammation, Subacute               |                                  2                                       |             
      Mucosa, Proliferation, Focal         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Myocardium, Degeneration, Multifocal |    1     2              1  1     1           1  2           1        1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Hyperplasia, Nodular                 |                1                                            2            |             
      Hypertrophy, Focal                   |                                           1                              |             
      Vacuolization Cytoplasmic, Focal     |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|             
                                           | 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Hyperplasia, Nodular                 |                1                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +        +  +|             
      Pars Distalis, Angiectasis, Focal    |                                                 1                        |             
      Pars Distalis, Cyst                  |       X                                                                  |             
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      C-Cell, Hyperplasia                  |    1     3     2        2  3     2        3  1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +     +     +        +  +     M     +  +  +  +           +  +  +  +   |             
      Hyperplasia                          |                                                                   3      |             
      Inflammation, Chronic                |                1           1           1     1                           |             
      Inflammation, Chronic Active         |                                                                3  2      |             
      Duct, Dilatation                     |                                                                3         |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +     +     +        +  +  +  +     +  +  +  +           +        +   |             
      Inflammation, Chronic                |                               3                                          |             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                               X                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +     +  +  +  +  +     +     +  +  +  +           +        +   |             
      Dilatation                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Femoral, Hyperplasia                 |    1     1                 2                                1            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +  +        +  +     +     +  +  +  +           +        +   |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             +            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +        +  +     +     +  +  +  +  +     +  +        +   |             
      Hematopoietic Cell Proliferation     |                                                 3                        |             
      Capsule, Hemorrhage                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +     +        I  +     +     +  +  +  +           +        +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +        +  +  +  +     +  +  +  +           +        +   |             
      Hyperplasia, Cystic                  |    2     3     2        4  3  3        3  4  4                       3   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +        +  +     +     +  +  +  +           +        +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|             
                                           | 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Acanthosis                           |                                              1                           |             
      Hyperkeratosis                       |                                              2                           |             
      Inflammation, Chronic                |                3                                                         |             
      Inflammation, Necrotizing            |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +     +        +  +     +     +  +  +  +           +        +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Infarct                              |                                                                          |             
      Inflammation, Multifocal, Necrotizing|                                                                          |             
      Hypothalamus, Compression            |          1     4        4              3  4  2                       3   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +     +        +  +     +     +  +  +  +           +  +     +   |             
      Alveolus, Hemorrhage                 |                3                                               1         |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                                                 1                        |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Sinus, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +     +        +  +     +     +  +  +  +           +        +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +              +                              |             
      Lens Crystalline, Cataract           |                                           3                              |             
      Posterior Chamber, Inflammation,     |                                                                          |             
           Chronic                         |                                           3                              |             
      Retina, Atrophy                      |                                                                          |             
      Sclera, Mineralization, Multifocal   |                            2                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Inflammation, Multifocal, Necrotizing|                                                                          |             
      Nephropathy, Multifocal              |                2        3              1  1  1                       2   |             
      Papilla, Bacterium                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +     +        +  +     +  +  +  +  +  +           +        +   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |          1                                                               |             
      Mucosa, Hyperplasia, Papillary       |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1|            |
                                           | 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                   +  +  +           +  +     +           +     +        +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                   +  +  +           +  +     +           +     A        +|  20        |
      Edema                                |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Basophilic Focus                     | X  X  X  X  X  X           X  X  X        X     X  X  X  X  X     X  X   |     35     |
      Clear Cell Focus                     |       X                                         X                        |      2     |
      Cyst                                 |                                                                          |      1     |
      Fatty Change                         |                                        1                 2               |      3  2.0|
      Granuloma, Multiple                  |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                         X|      1     |
      Necrosis, Coagulative, Multifocal    |                                                                          |      2  1.0|
      Necrosis, Caseous                    |                                                                          |      1  1.0|
      Regeneration, Focal                  |                                                                   2      |      1  2.0|
      Sinusoid, Angiectasis                |                                                                          |      1  1.0|
      Sinusoid, Angiectasis, Multifocal    |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                 +     +  +  +                                         +|   6        |
      Inflammation, Chronic                |                         2                                                |      1  2.0|
      Fat, Necrosis                        | 4                          4  4                                          |      3  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                   +  +  +           +  +     +           +     A        +|  20        |
      Acinus, Atrophy                      |                                     1  1                                2|      7  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                   +  +  +           +  +     +           +     +        +|  21        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                   +  +  +           +  +     +           +     A        +|  20        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Mucosa, Proliferation, Focal         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                   +  +  +           +  +     +           +     +        +|  21        |
      Myocardium, Degeneration, Multifocal |                   1                 1  1                       4         |     13  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1|            |
                                           | 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                   +  +  +           +  +     +        +  +     A        +|  21        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                   +  +  +           +  +     +        +  +     A        +|  21        |
      Hyperplasia, Nodular                 |                   1                                                      |      3  1.3|
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                   +  +  +           +  +     +        +  +     A        +|  21        |
      Hyperplasia, Nodular                 |                                     1                                   1|      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                   M  +  +           +  +     +           +     M        +|  18        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +     +|  41        |
      Pars Distalis, Angiectasis, Focal    |                                           2                              |      2  1.5|
      Pars Distalis, Cyst                  |                                  X  X     X                              |      4     |
      Pars Distalis, Hyperplasia, Nodular  |    1     3                                   2                           |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                   +  +  +           +  +     +           +     A        +|  20        |
      C-Cell, Hyperplasia                  |                   3  1  2           3        2           2               |     14  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                   +  +  +           +  +     I           +     +        +|  21        |
      Hyperplasia                          |                                                                3         |      2  3.0|
      Inflammation, Chronic                |                                                                          |      4  1.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                 +  +  +           +  +     +           +     +        +|  23        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Follicle, Cyst                       |                                                          X               |      1     |
      Periovarian Tissue, Cyst             | X                                      X                       X         |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                +  +  +  +           +  +     +     +     +     +        +|  26        |
      Dilatation                           |                4                    3                                    |      2  3.5|
      Endometrium, Hyperplasia, Cystic     |                                                    1                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                   +  +  +           +  +     +           +     +        +|  21        |
      Femoral, Hyperplasia                 |                   3                 2        3                          3|      8  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +  +  +           +  +     +           +     A        +|  21        |
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1|            |
                                           | 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                   +  +  +           +  +     +           +     +  +  +  +|  26        |
      Hematopoietic Cell Proliferation     |                         3                                                |      2  3.0|
      Capsule, Hemorrhage                  |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                   +  +  +           M  +     +           I     +        +|  18        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                   +  +  +           +  +     +           +  +  A        +|  24        |
      Hyperplasia, Cystic                  |                   4                 3  3                 1              2|     15  2.9|
                                            __________________________________________________________________________|____________|
   Skin                                    |                   +  +  +           +  +     +           +     +        +|  22        |
      Acanthosis                           |                                                                          |      1  1.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Necrotizing            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                   +  +  +           +  +     +           +     +        +|  21        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                   +  +  +           +  +     +           +     +        +|  21        |
      Infarct                              |                                                                3         |      1  3.0|
      Inflammation, Multifocal, Necrotizing|                      1                                                   |      1  1.0|
      Hypothalamus, Compression            |                   1                                                      |      8  2.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                   +  +  +           +  +     +           +     +        +|  22        |
      Alveolus, Hemorrhage                 |                   1                                                      |      3  1.7|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                         1                                                |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                   +  +  +           +  +     +           +     +        +|  21        |
      Sinus, Inflammation, Chronic Active  |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                   +  +  +           +  +     +           +     +        +|  21        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                      +  +                 +   |   6        |
      Lens Crystalline, Cataract           |          3                                      4  4                 2   |      5  3.2|
      Posterior Chamber, Inflammation,     |                                                                          |            |
           Chronic                         |          3                                         3                     |      3  3.0|
      Retina, Atrophy                      |                                                 4                    4   |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1|            |
                                           | 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Sclera, Mineralization, Multifocal   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                   +  +  +           +  +     +           +     +        +|  21        |
      Inflammation, Multifocal, Necrotizing|                      4                                                   |      1  4.0|
      Nephropathy, Multifocal              |                                     1  2     1           1              1|     11  1.5|
      Papilla, Bacterium                   |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                   +  +  +           +  +     +           +     A        +|  21        |
      Inflammation, Acute                  |                      4                                                   |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Mucosa, Hyperplasia, Papillary       |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|             
                                           | 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                   +     +        +  +  +     A  +        +  +     +     +|             
      Ulcer                                |                                  2                                       |             
      Submucosa, Edema                     |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                   +     +        +  +  +     A  +        +  +     +     +|             
      Parasite Metazoan                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X     X  X  X     X  X  X        X  X     X  X  X        X  X   |             
      Cyst                                 |                                  X                                       |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change                         |                                     3                       3            |             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Mixed Cell Focus                     |                X                                                         |             
      Regeneration, Focal                  |                                                                3         |             
      Centrilobular, Cytomegaly            | 1                             1           1           1                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Fat, Necrosis                        |          4                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                |                   +     +        +  +  +     +  +        +  +     +     +|             
      Fibrosis, Focal                      |                                  2                                       |             
      Acinus, Atrophy                      |                   2              3  2  1     1           2        2     4|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                   +     +        +  +  +     A  +        +  +     +     +|             
      Inflammation, Subacute               |                         2                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                             +            |             
      Gingiva, Inflammation, Chronic       |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                   +     +  +     +  +  +     +  +        +  +     +     +|             
      Autolysis                            |                                              2                           |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                   2                                                      |             
      Myocardium, Degeneration, Multifocal |                   1                 2  1     2  2        1        3      |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                   1                                                      |             
      Valve, Inflammation, Chronic         |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|             
                                           | 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                   +     +        +  +  +     +  +        +  +     +     +|             
      Hyperplasia, Nodular                 |                         1        1                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                   +     +        +  +  +     +  +        +  +     +     +|             
      Hyperplasia, Nodular                 |                   2              1     2                    1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                   +     +        +  +  +     +  +        +  +     +     +|             
      Hyperplasia, Diffuse                 |                                  3                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Pars Distalis, Angiectasis, Focal    |          2                                2                              |             
      Pars Distalis, Angiectasis,          |                                                                          |             
          Multifocal                       |                                     3                                    |             
      Pars Distalis, Cyst                  |                               X                       X                  |             
      Pars Distalis, Hyperplasia, Nodular  |       2     2                             2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                   +     +        +  +  +     A  +        +  +     +     +|             
      C-Cell, Hyperplasia                  |                         2           2  3        3        3  3     4     3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                   +     +  +     +  +  +     +  +        +  +     +     +|             
      Autolysis                            |                                              1                           |             
      Inflammation, Chronic                |                   1                          1                           |             
      Duct, Dilatation                     |                                                                   2      |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +  +     +        +  +  +     +  +        +  +     +     +|             
      Periovarian Tissue, Cyst             |                X                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  |                   +     +        +  +  +  +  +  +        +  +     +     +|             
      Dilatation                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Prolapse                             |                                                          X               |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
      Wall, Bacterium                      |                                                          X               |             
      Wall, Inflammation, Necrotizing      |                                                          3               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                   +     +        +  +  +     +  +        +  +     +     I|             
      Femoral, Hyperplasia                 |                         2              2                 3        3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +     +        +  +  +     +  +        +  +     +     +|             
      Mandibular, Inflammation, Chronic    |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|             
                                           | 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Hemosiderin                      |                                                 2                        |             
      Sinus, Ectasia                       |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +                                                      |             
      Sinus, Ectasia                       |                   3                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +     +        +  +  +     A  +     +  +  +     +     +|             
      Fibrosis, Focal                      |                                        1                                 |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Necrosis, Coagulative                |                                                                          |             
      Capsule, Inflammation, Focal,        |                                                                          |             
          Subacute                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                   +     +        +  +  +     +  +        +  +     +     +|             
      Hemorrhage, Multifocal               |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +                 +     +  +     +  +  +  +  +  +        +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                   4                 2  2     2  1           3           2|             
                                            __________________________________________________________________________|             
   Skin                                    |                   +     +        +  +  +     +  +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                   +     +        +  +  +     +  +        +  +  +  +     +|             
      Tibia, Proliferation                 |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                   +     +        +  +  +     +  +        +  +     +     +|             
      Infarct                              |                                                                          |             
      Infarct, Multiple                    |                                                 3                        |             
      Hypothalamus, Compression            |                   4     3                    3                           |             
      Hypothalamus, Hemorrhage, Multifocal |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                   +     +        +  +  +     +  +        +  +     +     +|             
      Alveolus, Hemorrhage, Multifocal     |                                              3                           |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                  1                                       |             
                                            __________________________________________________________________________|             
   Nose                                    |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |                   +     +        +  +  +     +  +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +     +     +                                                         |             
      Lens Crystalline, Cataract           |    4     2     3                                                         |             
      Posterior Chamber, Inflammation,     |                                                                          |             
           Chronic                         |    3           3                                                         |             
      Retina, Atrophy                      |          3                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +              +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|             
                                           | 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                          2              1|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                   +     +        +  +  +     +  +        +  +     +     +|             
      Nephropathy, Multifocal              |                   2     1        4  1           1           2     2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                   +     +        +  +  +     A  +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3|            |
                                           | 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +        +  +  +  +  +     +  +           +           +     +         |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
      Ulcer                                |                                                                          |      1  2.0|
      Submucosa, Edema                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X              X  X  X     X  X  X     X        X        X  X     X|     30     |
      Cyst                                 |                                                                          |      1     |
      Fatty Change, Diffuse                |             2                                   3                        |      2  2.5|
      Fatty Change                         |                                                          2               |      3  2.7|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Regeneration, Focal                  |                                                 3                        |      2  3.0|
      Centrilobular, Cytomegaly            | 1                                                     1     1            |      7  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +  +                                                         |   3        |
      Fat, Necrosis                        |             4  4                                                         |      3  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                   2     1     3                 2        1               |     13  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +           +  +  +  +     +  +           +  +        +     +         |  22        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Gingiva, Inflammation, Chronic       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +        +  +  +  +  +     +  +           +  +        +     +         |  24        |
      Autolysis                            |                                                                          |      1  2.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3|            |
                                           | 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Myocardium, Degeneration, Multifocal |                1                 1           1  2        1     1         |     13  1.5|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Valve, Inflammation, Chronic         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Hyperplasia, Nodular                 |             2        1        1  2              2                        |      7  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Hyperplasia, Nodular                 |             1     2                                                      |      6  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M        +  +  +  +  +     +  +           +  M        +     +         |  21        |
      Hyperplasia, Diffuse                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |  43        |
      Pars Distalis, Angiectasis, Focal    |          2                                   4     2                     |      5  2.4|
      Pars Distalis, Angiectasis,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |             X              X                    X                        |      5     |
      Pars Distalis, Hyperplasia, Nodular  |             2        1        1                    1                     |      7  1.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +        +  A  +  +  +     +  +           +  +        A     A         |  19        |
      C-Cell, Hyperplasia                  |    2        3        2  3        2              2                        |     14  2.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +        +  +  +  +  +     +  +           +  +        +     +         |  24        |
      Autolysis                            |                                                                          |      1  1.0|
      Inflammation, Chronic                |                         1     1                                          |      4  1.0|
      Duct, Dilatation                     |                                                 2                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +        +  +  +  +  +     +  +  +        +  +        +  +  +         |  26        |
      Periovarian Tissue, Cyst             |                X              X     X                       X            |      5     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +     +  +  +  +  +  +     +  +        +  +  +        +     +         |  26        |
      Dilatation                           |                                              3                           |      1  3.0|
      Hyperplasia                          |                3                                                         |      1  3.0|
      Prolapse                             |                                                                          |      1     |
      Cervix, Inflammation, Suppurative    |                               3                                          |      1  3.0|
      Wall, Bacterium                      |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3|            |
                                           | 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Wall, Inflammation, Necrotizing      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                               +                                          |   1        |
      Cyst                                 |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +        +  +  +  +  +     +  +           +  +        +     +         |  22        |
      Femoral, Hyperplasia                 |    1        3  2  3           2                 2        1               |     11  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +        +  +  +  +  +     +  +        +  +  +        +     +  +  +   |  26        |
      Mandibular, Inflammation, Chronic    |                                              3                           |      1  3.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  2.0|
      Sinus, Ectasia                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                               +           +                          +   |   4        |
      Sinus, Ectasia                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +  +  +  +  +  +     +  +        +  +  +  +     +     +  +  +   |  29        |
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                2                                                         |      1  2.0|
      Capsule, Inflammation, Focal,        |                                                                          |            |
          Subacute                         |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +        +  M  +  +  +     +              +  +        +     +         |  21        |
      Hemorrhage, Multifocal               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +        +  +  +  +  +     +  +        +  +  +        +  +  +     +   |  31        |
      Hyperplasia, Cystic                  |             2  1     1                          2              2         |     12  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +        +  +  +  +  +     +  +           +  +        +     +         |  24        |
      Tibia, Proliferation                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Infarct                              |                2                                                         |      1  2.0|
      Infarct, Multiple                    |                                                                          |      1  3.0|
      Hypothalamus, Compression            |                         2                                1               |      5  2.6|
      Hypothalamus, Hemorrhage, Multifocal |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3|            |
                                           | 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +        +  +  +  +  +     +  +           +  +        +     +  +      |  24        |
      Alveolus, Hemorrhage, Multifocal     |                         3                                                |      2  3.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +        +  +  +  +  +     +              +  +        +     +         |  22        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +        +                                               +            |   6        |
      Lens Crystalline, Cataract           |    2        4                                               3            |      6  3.0|
      Posterior Chamber, Inflammation,     |                                                                          |            |
           Chronic                         |             2                                               3            |      4  2.8|
      Retina, Atrophy                      |    4        4                                                            |      3  3.7|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   3        |
      Inflammation, Chronic, Multifocal    |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Nephropathy, Multifocal              |                   1           1  1                                       |     10  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +        +  +  +  +  +     +              +  +        +     A         |  20        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +                    +  +           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +                    +  A           A  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +                    +  A           A  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +                    +  A           A  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +                    +  A           A  +     +                    +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X     X  X     X     X        X  X     X     X     X  X  X  X  X      |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |    X              X              X                                       |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                                                    1                     |             
      Necrosis, Caseous, Multifocal        |                                           1                              |             
      Centrilobular, Cytomegaly            |    1        1  1                 1  1  1              1  1  1  1        1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
      Fat, Necrosis                        |                            4                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +                    +  A           +  +     +                    +|             
      Acinus, Atrophy                      |                            3                 1     1                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Stomach                                 |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +                    +  A           +  +     +                    +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +                    +  +           +  +     +                    +|             
      Myocardium, Degeneration, Multifocal |       1                                   2  1                          1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +                    +  +           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +                    +  +           +  +     +                    +|             
      Hyperplasia, Nodular                 |                                           2                              |             
      Vacuolization Cytoplasmic, Focal     |                            1                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +                    +  +           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +     +  +        +  +  +  +     +  +     +  +              +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Autolysis                            |                               3                                          |             
      Pars Distalis, Angiectasis, Focal    |          2                                                               |             
      Pars Distalis, Cyst                  |                               X                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia, Nodular  |                                                                         1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +                    +  A           A  +     +                    +|             
      C-Cell, Hyperplasia                  |       3                    1                 4     2                    2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       M           +        +  +           +  +     +                    +|             
      Inflammation, Chronic                |                            1                                            1|             
      Duct, Dilatation                     |                   3                                                     2|             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +                    +  +           +  +     +  +           +     +|             
      Inflammation, Chronic                |                                                                          |             
      Periovarian Tissue, Cyst             | X     X                                               X           X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +           +        +  +        +  +  +     +  +              +  +|             
      Dilatation                           |                   1                       4                              |             
      Endometrium, Hyperplasia, Cystic     |                                                                      3   |             
      Wall, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                                                      |             
      Cyst                                 |                                                                          |             
      Lumen, Exudate                       |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +                    +  A           +  +     +                    +|             
      Femoral, Hyperplasia                 |                            2                                            2|             
      Femoral, Myelofibrosis               |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +              +     +  +           +  +  +  +                 +  +|             
      Autolysis                            |                               3                                          |             
      Fibrosis, Diffuse                    |                                                    4                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Capsule, Cyst                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +                    +  A           +  +     +                    +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +           +        +  +           +  +     +                    +|             
      Hyperplasia, Cystic                  |       4                    1                 2     4                     |             
                                            __________________________________________________________________________|             
   Skin                                    |       +                    +  +           +  +     +              +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +                    +  +           +  +     +                    +|             
      Femur, Osteopetrosis                 |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +                    +  +           +  +     +                    +|             
      Hypothalamus, Compression            |       3                                      3                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +                    +  +           +  +     +                    +|             
      Alveolus, Inflammation, Multifocal,  |                                                                          |             
           Suppurative                     |                                                                          |             
      Bronchus, Foreign Body               |                                                                          |             
      Bronchus, Inflammation, Multifocal,  |                                                                          |             
           Suppurative                     |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                         1|             
                                            __________________________________________________________________________|             
   Nose                                    |       +                    +  +           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +                    +  +           +  +     +                    +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                         +  +        +   |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Lens Crystalline, Cataract           |                2                                         3  4        3   |             
      Posterior Chamber, Inflammation,     |                                                                          |             
           Chronic                         |                3                                         3  3        3   |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
      Inflammation, Chronic, Multifocal    |                                              1                           |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +                    +  +           +  +     +                    +|             
      Nephropathy, Multifocal              |                            1                       1                     |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +                    +  A           +  +     +                    +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +           +                       +                       +      |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A           +                       A                       +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A           +                       A                       +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A           +                       A                       +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A           +                       A                       +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A           +                       A                       +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A           +                       A                       +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A           +                       A                       +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A           +                       A                       +      |   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X     X  X  X     X  X  X  X  X  X  X     X  X  X        X  X     X  X|     33     |
      Cyst                                 |                               X                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      3     |
      Mixed Cell Focus                     |    X                                                                     |      1     |
      Necrosis, Coagulative, Multifocal    |                                                                          |      1  1.0|
      Necrosis, Caseous, Multifocal        |                                                                          |      1  1.0|
      Centrilobular, Cytomegaly            |             1  1     1        1  1  1  1           1  1              1  1|     22  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A           +                       A                       +      |  10        |
      Acinus, Atrophy                      |    1              3                                                      |      5  1.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +           +                       +                       +      |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  A  +        +                       +                       +      |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  A           +                       +                       +      |  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +        +                       A                       +      |  11        |
      Ulcer                                |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +           +                       +                       +      |  13        |
      Myocardium, Degeneration, Multifocal |    1                                                              1      |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +           +                       +                       +      |  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +           +                       +                       +      |  13        |
      Hyperplasia, Nodular                 |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                   2      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +           +                       +                       +      |  13        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A           +                       +                       +      |  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +           +                       +                       +      |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +        +  +     +        +     +  +  +  +  +        +  +  +  +|  32        |
      Angiectasis, Focal                   |                                                                         1|      1  1.0|
      Autolysis                            |                                                                          |      1  3.0|
      Pars Distalis, Angiectasis, Focal    |                            1                                             |      2  1.5|
      Pars Distalis, Cyst                  |                   X  X     X                       X                     |      6     |
      Pars Distalis, Hyperplasia, Nodular  |                   2  3                                                   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  A           +                       A                       +      |   9        |
      C-Cell, Hyperplasia                  | 2  2              3                                                      |      8  2.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +           +        +           +  M                       +      |  14        |
      Inflammation, Chronic                | 1                                      1                                 |      4  1.0|
      Duct, Dilatation                     |                                        3                                 |      3  2.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +           +     +        +  +     +                       +      |  19        |
      Inflammation, Chronic                |                                  2                                       |      1  2.0|
      Periovarian Tissue, Cyst             |                         X        X  X                                    |      7     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +     +  +  +     +  +        +        +     +        +      |  25        |
      Dilatation                           |                      3                                                   |      3  2.7|
      Endometrium, Hyperplasia, Cystic     |             4        2        2  2                                       |      5  2.6|
      Wall, Cyst                           |                                                    X                     |      1     |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                          +               |   2        |
      Cyst                                 |                                                          4               |      1  4.0|
      Lumen, Exudate                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +           +                       +                       +      |  12        |
      Femoral, Hyperplasia                 | 2                 3                                                      |      4  2.3|
      Femoral, Myelofibrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +           +                       +                       +      |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  A           +                       +              +        +  +   |  17        |
      Autolysis                            |                                                                          |      1  3.0|
      Fibrosis, Diffuse                    |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     | 3                                                                        |      1  3.0|
      Capsule, Cyst                        |                                                                      X   |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +           +                       +                       +      |  12        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +           +        +           +  +     +           +     +      |  19        |
      Hyperplasia, Cystic                  |    1                                                              3      |      6  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +           +                       +                       +      |  14        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +           +                       +                       +      |  13        |
      Femur, Osteopetrosis                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +           +                       +                       +      |  13        |
      Hypothalamus, Compression            |    3                                                              4      |      4  3.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +           +                       +                       +      |  13        |
      Alveolus, Inflammation, Multifocal,  |                                                                          |            |
           Suppurative                     |                                           3                              |      1  3.0|
      Bronchus, Foreign Body               |                                           3                              |      1  3.0|
      Bronchus, Inflammation, Multifocal,  |                                                                          |            |
           Suppurative                     |                                           3                              |      1  3.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                   1      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +           +                       +                       +      |  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +              +                       +                       +      |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +  +                                         +                  |   7        |
      Cornea, Inflammation, Suppurative    |                                                       3                  |      1  3.0|
      Lens Crystalline, Cataract           |          3  4                                                            |      6  3.2|
      Posterior Chamber, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      4  3.0|
      Retina, Atrophy                      |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic, Multifocal    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  A           +                       +           +           +      |  13        |
      Nephropathy, Multifocal              |    3                                                  3           2      |      5  2.0|
      Thrombosis                           | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A           +                       +                       +      |  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|             
                                           | 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +        +  +                 +  +        +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X  X  X     X  X  X     X  X  X  X  X  X  X  X  X     X        X   |             
      Clear Cell Focus                     |                                                    X                     |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Necrosis, Coagulative, Focal         |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Necrosis, Caseous, Multifocal        |                                                          1               |             
      Centrilobular, Cytomegaly            |    2  1     1              1  1     1  2     1     1  1        1     1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +        +  +                 +  +        A        +  +     +     +|             
      Acinus, Atrophy                      |                   2                    2                 1               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +        +  +                 +  +        +        +  +     +     +|             
      Ectopic Tissue                       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +        +  +                 +  +        +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +        +  +                 +  +        +        +  +     +     +|             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Acanthosis, Diffuse      |                                                                          |             
      Epithelium, Hyperkeratosis, Diffuse  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A     +        +  +                 +  +        A        +  +     +     +|             
      Inflammation, Chronic                |                                                                          |             
      Mucosa, Inflammation, Multifocal,    |                                                                          |             
           Necrotizing                     |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +        +  +                 +  +        +        +  +     +     +|             
      Myocardium, Degeneration, Diffuse    |                                                                          |             
      Myocardium, Degeneration, Multifocal |                1                    1           2           2            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +        +  +  +              +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +        +  +                 +  +        A        +  +     +     +|             
      Hyperplasia, Nodular                 |       1        3  2                 2  1                                1|             
      Hypertrophy, Multifocal              |                                                                          |             
      Necrosis, Coagulative                |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|             
                                           | 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +        +  +  +              +  +        A        +  +     +     +|             
      Hyperplasia, Nodular                 |       1           1                 1                                   1|             
      Necrosis, Coagulative                |                                                          4               |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +        +  +                 +  +        +        +  +     +     M|             
      Hyperplasia, Diffuse                 |                                                          2               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | A  +  +  +  +  +  +        +  +  +  +  +        +     +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                                  2                    4        1         |             
      Pars Distalis, Cyst                  |                            X  X                                          |             
      Pars Distalis, Hyperplasia, Nodular  |                2                       3                 2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | A     +        +  +                 +  +        A        +  +     +     +|             
      Cyst                                 |                                                                         X|             
      C-Cell, Hyperplasia                  |       2        2  2                 3  2                    3     2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +     +        +  +     +           +  +        +        +  +     +     M|             
      Inflammation, Chronic                |                                                                          |             
      Duct, Dilatation                     |                         2                                                |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +     +  +     +           +  +        +        +  +     +  +  +|             
      Bilateral, Periovarian Tissue, Cyst  |                                                                      X   |             
      Periovarian Tissue, Cyst             |          X        X     X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +     +  +  +     +        +  +  +  +  +        +  +  +  +  +  +|             
      Dilatation                           |                                           2                              |             
      Hemorrhage                           |                                                                          |             
      Cervix, Inflammation, Suppurative    |                                                                      2   |             
      Endometrium, Hyperplasia, Cystic     |       3                                   2                             3|             
      Endometrium, Hyperplasia, Nodular    |                                              2                           |             
      Lumen, Hemorrhage                    |                                     4                                    |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                                      +           +   |             
      Cyst                                 |                   3                                      4           3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +        +  +                 +  +        +        +  +     +     +|             
      Femoral, Hyperplasia                 |                1  2                 3  2                 1        3     3|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +        +  +  +              +  +        +        +  +     +     +|             
      Mandibular, Hemorrhage, Focal        |                                                                          |             
      Sinus, Mandibular, Ectasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +     +                                                  +|             
      Sinus, Ectasia                       |                      1                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +        +  +                 +  +        A        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|             
                                           | 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +        +  M                 +  +        +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +        +  +                 +  +        +        +  +     +  +  +|             
      Hyperplasia, Cystic                  | 2              3  2                 3  1        2        2  2        3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +              +  +     +  +        +  +     +     +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Tail, Acanthosis, Focal              |                      3                                                   |             
      Tail, Hyperkeratosis, Focal          |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +        +  +                 +  +        +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +        +  +                 +  +        +        +  +     +     +|             
      Hypothalamus, Compression            |                                                 3           2            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +        +  +                 +  +        +        +  +     +     +|             
      Congestion                           |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                        1                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +        +  +                 +  +        +        +  +     +     +|             
      Nares, Inflammation, Chronic Active  |                   2                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +        +  +                 +  +        +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +        +                          +           +                  |             
      Anterior, Synechia                   |       2                                                                  |             
      Lens Crystalline, Cataract           |                                                       4                  |             
      Posterior Chamber, Inflammation,     |                                                                          |             
           Chronic                         |                                           3           3                  |             
      Retina, Atrophy                      |       3                                                                  |             
      Sclera, Mineralization, Multifocal   |                2                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                             +            |             
      Inflammation, Chronic, Multifocal    |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +        +  +                 +  +        +        +  +     +     +|             
      Nephropathy, Multifocal              |                   1                 1  1                 2               |             
      Glomerulus, Inflammation,            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|             
                                           | 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Membranoproliferative            |                                                          3               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A     +        +  +                 +  +        A        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3|            |
                                           | 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +                       +  +  +        +  +     +        +  +     +   |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X  X  X  X  X  X  X  X     X  X  X        X  X  X     X     X  X  X|     35     |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |       X                                                                  |      1     |
      Fatty Change                         |    3                                                                     |      1  3.0|
      Necrosis, Coagulative, Focal         |                                           1                              |      1  1.0|
      Necrosis, Coagulative, Multifocal    | 2                                                                        |      1  2.0|
      Necrosis, Caseous, Multifocal        |                                                                          |      1  1.0|
      Centrilobular, Cytomegaly            |       1  1  1  1  1  1  1           1  1        1     1           1      |     24  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +                       +  +  +        +  +     +        +  +     +   |  21        |
      Acinus, Atrophy                      |    1                                                                 2   |      5  1.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Ectopic Tissue                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Inflammation, Chronic                |    3                                                                     |      1  3.0|
      Epithelium, Acanthosis, Diffuse      | 2                                                                        |      1  2.0|
      Epithelium, Hyperkeratosis, Diffuse  | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Inflammation, Chronic                |    3                                                                     |      1  3.0|
      Mucosa, Inflammation, Multifocal,    |                                                                          |            |
           Necrotizing                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Myocardium, Degeneration, Diffuse    |    1                                                                     |      1  1.0|
      Myocardium, Degeneration, Multifocal |                            1  1                    2                 1   |      8  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3|            |
                                           | 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +                       +  +  +        +  +              +  +     +   |  20        |
      Hyperplasia, Nodular                 | 2  2                          2                                          |      9  1.8|
      Hypertrophy, Multifocal              |                                                             2            |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Hyperplasia, Nodular                 |    1                       1  1                                          |      7  1.0|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic, Focal     |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +                       +  +  +        +  +     +        +  +     +   |  21        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +                       +  +  M        +  +     +        +  M     +   |  19        |
      Hyperplasia, Diffuse                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +     +  +        +  +  +        +  M  +  +  +     +  +     +  +|  35        |
      Pars Distalis, Angiectasis, Focal    | 2                                                                        |      4  2.3|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia, Nodular  | 2                                               2     1                  |      6  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Cyst                                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |    3                       2  2  2        2  4     2        2  2         |     16  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +        +              +  +  +     +  +  +     +        +  +     +   |  24        |
      Inflammation, Chronic                | 1                                            1                           |      2  1.0|
      Duct, Dilatation                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +        +              +  +  +        +  +     +        +  +     +   |  26        |
      Bilateral, Periovarian Tissue, Cyst  |                                                                          |      1     |
      Periovarian Tissue, Cyst             |             X                                                            |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +              +  +  +  +     +  +  +  +     +  +  +     +   |  35        |
      Dilatation                           |                                                          4               |      2  3.0|
      Hemorrhage                           |                                                                      3   |      1  3.0|
      Cervix, Inflammation, Suppurative    |                                                                      4   |      2  3.0|
      Endometrium, Hyperplasia, Cystic     |          2                          1                    1               |      6  2.0|
      Endometrium, Hyperplasia, Nodular    |                                                                          |      1  2.0|
      Lumen, Hemorrhage                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                      +   |   4        |
      Cyst                                 |                                                                      3   |      4  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3|            |
                                           | 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Femoral, Hyperplasia                 | 3                             2  4        3  2                 3     1   |     14  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +                       +  +  +        +  +     +        +  +     +   |  23        |
      Mandibular, Hemorrhage, Focal        |                                                             1            |      1  1.0|
      Sinus, Mandibular, Ectasia           |                                                    1                 1   |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                               +           +  +                           |   6        |
      Sinus, Ectasia                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +                       +  +  +        +  +     +     +  +  +     +   |  22        |
      Hematopoietic Cell Proliferation     |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M                       +  +  +        +  +     +           +     +   |  19        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +              +  +     +  +  +        +  +     +        +  +     +   |  25        |
      Hyperplasia, Cystic                  |                            4  1           3  3     4                 3   |     15  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                       +  +  +  +     +  +     +        +  +     +   |  26        |
      Acanthosis                           |                                     3                                    |      1  3.0|
      Hyperkeratosis                       |                                     4                                    |      1  4.0|
      Tail, Acanthosis, Focal              |                                                                          |      1  3.0|
      Tail, Hyperkeratosis, Focal          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Hypothalamus, Compression            |                            4                       2                     |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                    +  +  +  +        +  +     +        +  +     +   |  23        |
      Congestion                           |                         1                                                |      1  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Nares, Inflammation, Chronic Active  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3|            |
                                           | 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                         +        +            |   7        |
      Anterior, Synechia                   |                                                                          |      1  2.0|
      Lens Crystalline, Cataract           |          4                                         4        1            |      4  3.3|
      Posterior Chamber, Inflammation,     |                                                                          |            |
           Chronic                         |          3                                         3        1            |      5  2.6|
      Retina, Atrophy                      |                                                                          |      1  3.0|
      Sclera, Mineralization, Multifocal   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic, Multifocal    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Nephropathy, Multifocal              |    4                       2              1        1           1         |      9  1.6|
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|             
                                           | 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +  A        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +  A        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +  A        +           +     +  +     +  +     +  +         |             
      Parasite Metazoan                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +  A        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +  A        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +  A        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +  A        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +  A        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X        X  X     X     X     X     X  X        X        X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                           3                              |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                2                                                         |             
      Regeneration, Focal                  |                3                                                         |             
      Centrilobular, Cytomegaly            | 1  1  1  1        1  1     1     1     1        1        1     1  1  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |             A  +        +           +     +  +     +  +     +  +         |             
      Acinus, Atrophy                      |                         1                 1                 1            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +  +        +           +     +  +     +  +     +  +         |             
      Parotid Gland, Inflammation, Chronic |                1                                                         |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +  +        +           +     +  +     +  +     +  +         |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +  +        +           +     +  +     +  +     +  +         |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Myocardium, Degeneration, Multifocal |                1                             1                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +  +        +           +     +  +     +  +     +  +         |             
      Atrophy                              |                                              3                           |             
      Hyperplasia, Nodular                 |                                     3                                    |             
      Hypertrophy, Focal                   |                                           2                              |             
      Vacuolization Cytoplasmic, Focal     |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|             
                                           | 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +  +        +           +     +  +     +  +     +  +         |             
      Hyperplasia, Nodular                 |                1        1                                      2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             A  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +  +  +     +  +  +        +     +  +  +  +  +  +  +  +     +   |             
      Pars Distalis, Angiectasis, Focal    |                                     3           2                        |             
      Pars Distalis, Cyst                  |                                     X                 X              X   |             
      Pars Distalis, Hyperplasia, Nodular  |                2                                            1            |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +  A        +           +     +  +     +  +     +  +         |             
      C-Cell, Hyperplasia                  |             3           2           2     3  3     1  1     3  3         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |          +  +  +        +     +     +     +  +     +  +  +  +  +         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Dilatation                     |                               3                          2               |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +  +     +  +     +     +     +  +     +  +        +     +   |             
      Periovarian Tissue, Cyst             |                      X        X                                      X   |             
      Periovarian Tissue, Necrosis, Caseous|                                           1                              |             
      Vein, Congestion                     |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +        +  +  +  +  +        +  +  +  +  +     +  +     +  +  +      |             
      Dilatation                           |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
      Cervix, Inflammation, Suppurative    |    2                 3                                            3      |             
      Endometrium, Hyperplasia, Cystic     |                                  3                                       |             
      Endometrium, Necrosis, Coagulative   |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                 +                    +                    +  +      |             
      Cyst                                 |    3                 4                    2                    3  3      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +  +        +           +     +  +     +  +     +  +         |             
      Femoral, Hyperplasia                 |             2                       1     2        2  3     2            |             
      Femoral, Myelofibrosis               |             2  4                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +  +        +     +     +     +  +     +  +     +  +        +|             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Polymorphonuclear               |                2                                                         |             
      Renal, Necrosis, Caseous             |                                           2                              |             
      Sinus, Mandibular, Ectasia           |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +                       +           +           +        +         |             
      Sinus, Ectasia                       |       3                       4                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|             
                                           | 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +  +        +     +     +     +  +     +  +     +  +         |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +  +        +           +     +  +     +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +  +        +           +     +  +  +  +  +     +  +         |             
      Hyperplasia, Cystic                  |             2  2        3           2     1  2                           |             
                                            __________________________________________________________________________|             
   Skin                                    |             +  +        +        +  +     +  +     +  +     +  +         |             
      Acanthosis                           |                                  2                                       |             
      Hyperkeratosis                       |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +  +        +           +     +  +     +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +  +        +           +     +  +     +  +     +  +         |             
      Hypothalamus, Compression            |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +  +        +           +     +  +     +  +     +  +         |             
      Alveolus, Hemorrhage                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +  +        +           +     +  +     +  +     +  +         |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
      Middle Ear, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                       3                  |             
                                            __________________________________________________________________________|             
   Eye                                     |    +  +                       +                    +     +               |             
      Bilateral, Lens Crystalline, Cataract|                                                                          |             
      Lens Crystalline, Cataract           |    4  4                       2                    4     2               |             
      Posterior Chamber, Inflammation,     |                                                                          |             
           Chronic                         |    2  2                       3                    3     3               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +  +        +           +     +  +     +  +     +  +         |             
      Nephropathy, Multifocal              |                                     1                 1                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +  +        +           +     +  +     +  +     M  +         |             
      Ectasia                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3|            |
                                           | 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +     +                                +     +           +  +  +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +     +                                +     +           +  +  +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +                                +     +           +  +  +      |  16        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     +                                +     +           +  +  +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +     +     +                          +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +     +                                +     +           +  +  +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +     +                                +     +           +  +  A      |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +     +     +                          +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X        X  X  X  X  X  X  X  X  X     X  X  X  X  X           X   |     31     |
      Clear Cell Focus                     |                                                                      X   |      1     |
      Eosinophilic Focus                   |                                     X                                    |      1     |
      Fatty Change                         |                                                             4            |      2  3.5|
      Mixed Cell Focus                     |                            X        X                                    |      2     |
      Necrosis, Coagulative, Multifocal    |                                                                          |      1  2.0|
      Regeneration, Focal                  |                                                                          |      1  3.0|
      Centrilobular, Cytomegaly            | 1     1        1     1     1  1  1  1  1     1     1  1  1           1   |     29  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                             +            |   2        |
      Fat, Necrosis                        |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +                                +     +           +  +  +      |  16        |
      Acinus, Atrophy                      |                                           1                       3      |      5  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +     +                                +     +           +  +  +      |  17        |
      Parotid Gland, Inflammation, Chronic |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +                                +     +           +  +  +      |  16        |
      Edema                                |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +                                +     +           +  +  +      |  16        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +     +                                +     +           +  +  +      |  17        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |          2                                                               |      1  2.0|
      Myocardium, Degeneration, Multifocal |                                                 1              2  1      |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +                                +     +           +  +  +      |  17        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3|            |
                                           | 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +     +                                +     +           +  +  +      |  17        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia, Nodular                 |          2                                2     1              2         |      5  2.0|
      Hypertrophy, Focal                   |                                                                1         |      2  1.5|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +     +                                +     +           +  +  +      |  17        |
      Hyperplasia, Nodular                 |                                                             1            |      4  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +     +                                +     +           +  +  +      |  16        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +              +  +     +  +     +     +  +  +  +  +  +  +  +   |  33        |
      Pars Distalis, Angiectasis, Focal    | 2                                                     2  2        4      |      6  2.5|
      Pars Distalis, Cyst                  |       X                          X                                       |      5     |
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |      2  1.5|
      Pars Intermedia, Cyst                |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +     +                                +     +           +  +  +     +|  17        |
      C-Cell, Hyperplasia                  |    2     2                                2     4           3  3  1      |     16  2.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +     +                                +     +           +  +  +      |  20        |
      Inflammation, Chronic                |    1                                      1                 1  1         |      4  1.0|
      Inflammation, Chronic Active         |          2                                                               |      1  2.0|
      Duct, Dilatation                     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +           +                    +     +           +  +  +      |  21        |
      Periovarian Tissue, Cyst             | X                    X                                                   |      5     |
      Periovarian Tissue, Necrosis, Caseous|                                                                          |      1  1.0|
      Vein, Congestion                     |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +     +  +     +     +        +  +     +           +  +  +     +|  31        |
      Dilatation                           | 3                                                                        |      1  3.0|
      Hyperplasia, Cystic                  |                                                 3                        |      1  3.0|
      Cervix, Inflammation, Suppurative    |                               3                                         2|      5  2.6|
      Endometrium, Hyperplasia, Cystic     |                                        3                                 |      2  3.0|
      Endometrium, Necrosis, Coagulative   |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                               +                                         +|   7        |
      Cyst                                 |                               3                                         2|      7  2.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3|            |
                                           | 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +     +                                +     +           +  +  +      |  17        |
      Femoral, Hyperplasia                 |                                           2                 3            |      8  2.1|
      Femoral, Myelofibrosis               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +     +                          +     +           +  +  +     +|  22        |
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Polymorphonuclear               |                                                                          |      1  2.0|
      Renal, Necrosis, Caseous             |                                                                          |      1  2.0|
      Sinus, Mandibular, Ectasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                         +|   6        |
      Sinus, Ectasia                       |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +  +  +                          +     +           +  +  +     +|  21        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +     +                                +     +           +  +  +     M|  17        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +     +     +  +  +     +        +     +     +           +  +  +      |  23        |
      Hyperplasia, Cystic                  |    3     4                 4        4     2                    2         |     12  2.6|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +                                +     +           +  +  +      |  18        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +                                +     +           +  +  +      |  17        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +     +                                +     +           +  +  +      |  17        |
      Hypothalamus, Compression            |    4     4                                                     4  4      |      5  3.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +                                +     +           +  +  +     +|  18        |
      Alveolus, Hemorrhage                 |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +     +                                +     +           +  +  +      |  17        |
      Inflammation, Subacute               |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Middle Ear, Inflammation, Chronic    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3|            |
                                           | 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |          +        +                 +                                   +|   9        |
      Bilateral, Lens Crystalline, Cataract|          3                                                               |      1  3.0|
      Lens Crystalline, Cataract           |                   1                 3                                   4|      8  3.0|
      Posterior Chamber, Inflammation,     |                                                                          |            |
           Chronic                         |          2        3                 3                                    |      8  2.6|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +                                +     +           +  +  +      |  17        |
      Nephropathy, Multifocal              |    2     2                                                     1  1      |      6  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +                                +     +           +  +  +      |  16        |
      Ectasia                              |                                                 3                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|             
                                           | 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                                 X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Inflammation, Chronic Active, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X              X                                                  X|             
      Clear Cell Focus                     |             X                                                            |             
      Eosinophilic Focus                   |                   X  X  X                                                |             
      Mixed Cell Focus                     |                               X                                          |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Centrilobular, Cytomegaly            | 1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1        1|             
      Sinusoid, Angiectasis                |                                                                      4   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    1     2        1  1     1     1           1     1  1        1     1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Parotid Gland, Atrophy       |                                           1                              |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Proliferation, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
      Dysplasia                            |                                                    2                     |             
      Gingiva, Inflammation, Chronic Active|                                                                          |             
      Gingiva, Inflammation, Suppurative   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium Left, Thrombosis              |                         X                                                |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                    1                     |             
      Endocardium, Proliferation           |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
      Myocardium, Degeneration, Multifocal | 1  3  2  2     1        1     1  1  1  1  1     1                 1     1|             
      Myocardium, Fibrosis, Focal          |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|             
                                           | 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                2              1  2  1     1  1     1  1     1  2     1  1|             
      Hypertrophy, Focal                   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                  2                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |       1  1  2        1  3  1     2                 2              1     1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Pars Distalis, Angiectasis, Focal    |                         3                                                |             
      Pars Distalis, Hyperplasia, Nodular  |    1  1           2                                1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  3  2  3  2  3  3  1     2  2  1     3  1  2  1  2  2  1     2  3     2|             
      Follicle, Dilatation, Focal          |                                                    1                     |             
      Follicle, Dilatation, Multifocal     |                   2  1                                                   |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
      Inflammation, Chronic                |       1                                                           1      |             
      Inflammation, Chronic Active         |                2                          2                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                            X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prolapse                             |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |          2        3                                            2         |             
      Endometrium, Necrosis, Coagulative   |                                                    4                     |             
      Wall, Inflammation, Chronic Active   |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                              +                           |             
      Cyst                                 |                                              4                           |             
      Prolapse                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia                 |                            2                                      2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|             
                                           | 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sinus, Mandibular, Ectasia           |                                                    3        2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                       +           +      |             
      Sinus, Ectasia                       |                                                       3                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                      3  3  3     1        1     2     2  1  2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis, Focal                       |                                                                      1   |             
      Infarct                              |                                                                          |             
      Hypothalamus, Compression            |                                  3        4           3                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolus, Hemorrhage                 |             2                                                            |             
      Artery, Mineralization               |                                              1                           |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                         1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                    +     +              +        +  +            |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                             4            |             
      Lens Crystalline, Cataract           |       3                    4     3              4        2               |             
      Posterior Chamber, Inflammation,     |                                                                          |             
           Chronic                         |                                  3                       2               |             
      Retina, Atrophy                      |       4                    3     4              4        4               |             
      Sclera, Mineralization, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +     +              +     +        +   |             
      Inflammation, Chronic, Multifocal    |                                  1     1              1     2            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|             
                                           | 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Multifocal              |             1                 1  1        1           2  1              2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                1         |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                   X                                                      |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active, Focal  |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                   X                       X                       X      |      6     |
      Clear Cell Focus                     |                         X                                                |      2     |
      Eosinophilic Focus                   |          X                          X                                    |      5     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Coagulative, Multifocal    |                                                       1                  |      1  1.0|
      Centrilobular, Cytomegaly            | 1  1  2        1  1  2  1  1  1  2  1  1  1     2  1        1  1  1  1  1|     42  1.1|
      Sinusoid, Angiectasis                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |    1  1     2  1        1  1        1  4           1  3              1   |     22  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Parotid Gland, Atrophy       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |    2                                                                     |      1  2.0|
      Inflammation, Suppurative            |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Proliferation, Focal         |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                              +              +            |   3        |
      Dysplasia                            |                                                                          |      1  2.0|
      Gingiva, Inflammation, Chronic Active|                                                             4            |      1  4.0|
      Gingiva, Inflammation, Suppurative   |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium Left, Thrombosis              |                                                                          |      1     |
      Coronary Artery, Inflammation,       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
          Chronic                          |                                                                          |      1  1.0|
      Endocardium, Proliferation           |                                           2                              |      1  2.0|
      Epicardium, Inflammation, Chronic    |                                                             1     1      |      2  1.0|
      Myocardium, Degeneration, Multifocal | 1  2  1  1     1     1        1        1        1  1  2        1        1|     27  1.2|
      Myocardium, Fibrosis, Focal          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Nodular                 | 1  1  1                       1     2           2           2     2  2  2|     22  1.4|
      Hypertrophy, Focal                   |                            1     1                                       |      2  1.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Nodular                 |       1                    2  1  1        1  1     1        1            |     18  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |          2                                                               |      1  2.0|
      Pars Distalis, Angiectasis, Focal    |                                        2                 3               |      3  2.7|
      Pars Distalis, Hyperplasia, Nodular  |    1           2                 2                 3              3     2|     10  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 2  3  2  1  2  2     1  2  3  3  1  3  3  2  2  3     1     2  2  3  2  2|     43  2.1|
      Follicle, Dilatation, Focal          |                                                                         1|      2  1.0|
      Follicle, Dilatation, Multifocal     |                                                                          |      2  1.5|
      Follicular Cell, Hyperplasia, Focal  |                                           1                              |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                2                                            2            |      3  2.0|
      Inflammation, Chronic                |             2                                   1           1  1        1|      7  1.1|
      Inflammation, Chronic Active         |                   3                                   2                  |      4  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Cyst                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Prolapse                             |                      X                                                   |      1     |
      Endometrium, Hyperplasia, Cystic     |                                        3                       1     4   |      6  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Necrosis, Coagulative   |                               4                                          |      2  4.0|
      Wall, Inflammation, Chronic Active   |                      3                 3                                 |      2  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                      +                                                   |   2        |
      Cyst                                 |                                                                          |      1  4.0|
      Prolapse                             |                      X                                                   |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hyperplasia                 |          3  3                    2           3        1                  |      8  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Sinus, Mandibular, Ectasia           |                                                             2            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                              +           +               |   4        |
      Sinus, Ectasia                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |       3           3                                                      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |          1        1  3     2        2     2              3               |     16  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gliosis, Focal                       |                                                                          |      1  1.0|
      Infarct                              |                                                       4                  |      1  4.0|
      Hypothalamus, Compression            |                      3                                                   |      4  3.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolus, Hemorrhage                 |                                                       1                  |      2  1.5|
      Artery, Mineralization               |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                    +                                       |   8        |
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  4.0|
      Lens Crystalline, Cataract           |                                  3                                       |      6  3.2|
      Posterior Chamber, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      2  2.5|
      Retina, Atrophy                      |                                  4                                       |      6  3.8|
      Sclera, Mineralization, Multifocal   |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                +               |   7        |
      Inflammation, Chronic, Multifocal    |                         1                                                |      5  1.2|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Multifocal              |                1     1  1  1  1     1              1              1      |     15  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                1         |      2  1.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                                                         2|      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|             
                                           | 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic, Focal         |                                                       1                  |             
      Parasite Metazoan                    |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X                                   X                              |             
      Clear Cell Focus                     |                                                    X                     |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X                             X                     |             
      Mixed Cell Focus                     |             X                                                            |             
      Regeneration, Focal                  |                                                                          |             
      Centrilobular, Cytomegaly            |    1     1  1  1  1  1  1  1     1  1  1        1  1     1  1  1  1     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Acinus, Atrophy                      |    2                             1  1                    2               |             
      Acinus, Hypertrophy, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Gingiva, Inflammation, Chronic Active|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium Left, Thrombosis              |                               X                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Epicardium, Inflammation, Chronic    |       1                                                                  |             
      Myocardium, Degeneration, Multifocal |    1     1                       2  3     1     1     1     1  2         |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                         1                                                |             
      Valve, Inflammation, Chronic         |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|             
                                           | 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |          2                             2        2        3  1     1      |             
      Mineralization, Focal                |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |    1  3  2  1                 1              1  1  1  2  1              1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |       3  3                                                               |             
      Pars Distalis, Cyst                  |                                  X                                       |             
      Pars Distalis, Hyperplasia, Nodular  |                                           1                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  1  1  2                       2  2  1  2  2  1  2  1  2  1  2  3     2|             
      Follicle, Hyperplasia, Focal         |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
      Inflammation, Chronic                |                                  1  1           2           1            |             
      Inflammation, Chronic Active         |                                           2                              |             
      Duct, Dilatation                     |                                                 3                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Cyst                       |                                                    X                     |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prolapse                             |                                              X                           |             
      Endometrium, Hyperplasia, Cystic     |    1                             2                          4            |             
      Endometrium, Necrosis, Coagulative   |                                                                          |             
      Wall, Bacterium                      |                                              X                           |             
      Wall, Inflammation, Chronic Active   |                                              3                    2      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                   +     +|             
      Cyst                                 |                                                                   4     4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia                 |          2                                            3              3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|             
                                           | 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    2        2                                3     2  2  1        1      |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               3                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                2  1  2                                                   |             
      Artery, Mineralization               |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                         1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lamina Propria, Inflammation, Chronic|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                                                        |             
      Canal, External Ear, Exudate,        |                                                                          |             
          Subacute                         | 2                                                                        |             
      Middle Ear, Inflammation, Chronic    |                                                                          |             
      Middle Ear, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
      Middle Ear, Inflammation, Subacute   |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                      +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|             
                                           | 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lens Crystalline, Cataract           |                                  1                                      3|             
      Retina, Atrophy                      |                                                                         4|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Inflammation, Multifocal, Necrotizing| 4                                                                        |             
      Nephropathy, Multifocal              |             1                 1     1                       1     1  1  1|             
      Pelvis, Renal Tubule, Bacterium      | X                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  | 2                                                                        |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Diffuse                         | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8|            |
                                           | 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                           4                              |      1  4.0|
      Inflammation, Chronic, Focal         |                1                                                         |      2  1.0|
      Parasite Metazoan                    |                   X                                                      |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                      X   |      3     |
      Clear Cell Focus                     | X                                            X                           |      3     |
      Eosinophilic Focus                   |                                  X                                X      |      2     |
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Mixed Cell Focus                     |                      X  X        X                                       |      4     |
      Regeneration, Focal                  |                                                    2                     |      1  2.0|
      Centrilobular, Cytomegaly            | 1  1  1  1     1  2  1  1  1  2  1  1  1  1  2  1     1  1        1  1   |     38  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectopic Tissue                       |                            X                                             |      1     |
      Acinus, Atrophy                      | 1  1           2  1     3  1           1           2  1        1         |     14  1.4|
      Acinus, Hypertrophy, Focal           |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Subacute               |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                       +                  |   1        |
      Gingiva, Inflammation, Chronic Active|                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium Left, Thrombosis              |                                                                          |      1     |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                  2                                       |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8|            |
                                           | 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Epicardium, Inflammation, Chronic    |                                        1                                 |      2  1.0|
      Myocardium, Degeneration, Multifocal |    1     1              1  1  2        1           1     1  1        1  2|     20  1.3|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                      1                 1        1                 1      |      5  1.0|
      Valve, Inflammation, Chronic         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Nodular                 |          1        3  1  1           1              1  1     2     2      |     15  1.6|
      Mineralization, Focal                |                         1                                                |      1  1.0|
      Vacuolization Cytoplasmic, Focal     |                                                                         1|      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Nodular                 |                         2           2              2                    1|     15  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis, Focal    |                                                                          |      2  3.0|
      Pars Distalis, Cyst                  | X                                            X                 X         |      4     |
      Pars Distalis, Hyperplasia, Nodular  |                   1                                                      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 3        4  2  1  2  2  1  2  1  3  1  3  2  1  2  2  1  1  1  2  2     2|     39  1.8|
      Follicle, Hyperplasia, Focal         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                | 1     1  1                                            1  1               |      9  1.1|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Duct, Dilatation                     | 3                                                     2                  |      3  2.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                      1  3|      2  2.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Periovarian Tissue, Cyst             |                                  X                 X                     |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Prolapse                             |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8|            |
                                           | 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Hyperplasia, Cystic     |                      4              2     3  2     2              3  4   |     10  2.7|
      Endometrium, Necrosis, Coagulative   |                                                 4                        |      1  4.0|
      Wall, Bacterium                      |                                                                          |      1     |
      Wall, Inflammation, Chronic Active   |                                                                      4   |      3  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                     +                                    |   3        |
      Cyst                                 |                                     4                                    |      3  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hyperplasia                 |             2  2                             3     2           3     1   |      9  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +  +                                               +         |   3        |
      Sinus, Ectasia                       |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Cystic                  |       1  2     1        2     2     2  1  1     2  3        2     2  2  3|     21  1.9|
      Necrosis, Coagulative                |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                           3                              |      1  3.0|
      Inflammation, Chronic                |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypothalamus, Compression            |                               4                                         4|      2  4.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      3  1.7|
      Artery, Mineralization               |                      1                                                   |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8|            |
                                           | 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lamina Propria, Inflammation, Chronic|                         1                                1               |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                       +        +        +|   4        |
      Canal, External Ear, Exudate,        |                                                                          |            |
          Subacute                         |                                                                          |      1  2.0|
      Middle Ear, Inflammation, Chronic    |                                                       2                  |      1  2.0|
      Middle Ear, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                         2|      1  2.0|
      Middle Ear, Inflammation, Subacute   |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                    +                                 |   4        |
      Lens Crystalline, Cataract           |                   4                    4                                 |      4  3.0|
      Retina, Atrophy                      |                   4                    4                                 |      3  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                                +                                    |   2        |
      Inflammation, Chronic, Multifocal    |    1                                1                                    |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                               2                                          |      1  2.0|
      Inflammation, Multifocal, Necrotizing|                                                                          |      1  4.0|
      Nephropathy, Multifocal              |          1     1                 1  1        1  1           1        2   |     15  1.1|
      Pelvis, Renal Tubule, Bacterium      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Diffuse                         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|             
                                           | 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Arteriole, Inflammation, Chronic     |                               3                                          |             
      Arteriole, Thrombosis                |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A|             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|             
      Ulcer                                |                                                       1                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 1           X  X  X     X              X  X        X     X           X   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                      2              1                                    |             
      Eosinophilic Focus                   |                         X                    X        X                  |             
      Fatty Change                         |          2                             1                                 |             
      Mixed Cell Focus                     |                            X                                             |             
      Necrosis, Coagulative, Multifocal    |                   1  1           2                                       |             
      Necrosis, Caseous, Focal             |          1                                                               |             
      Sinusoid, Angiectasis                |                                                                          |             
      Sinusoid, Angiectasis, Multifocal    |                   2                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                        +|             
      Inflammation, Chronic                |                1                                                         |             
      Fat, Necrosis                        |                                                                         4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2  2  3  1                 1  3           3     1  1     1  2     1     2|             
      Artery, Inflammation, Chronic        |                               4                                          |             
      Duct, Concretion                     |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Submandibular Gland, Atrophy |    1                                                                     |             
      Parotid Gland, Inflammation, Chronic |                                     1                                    |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Ulcer                                |       3  4                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Ulcer                                |                                                             1            |             
      Arteriole, Submucosa, Thrombosis     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|             
                                           | 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium Left, Thrombosis              |                                                                   X      |             
      Myocardium, Degeneration, Multifocal | 1  1  2     3  3  3  3  3  2  2     3     3  3     1  2  1  2  2  2  3  2|             
      Myocardium, Fibrosis, Focal          |                   2                                                      |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                                                          |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                        1                                 |             
      Myocardium, Inflammation, Multifocal,|                                                                          |             
           Necrotizing                     |                                                                          |             
      Valve, Bacterium                     |                                  X                                       |             
      Valve, Inflammation, Chronic Active  |                                  3                                       |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 | 3     1  2  3     2     2                    1     4  3     1        1   |             
      Hypertrophy, Focal                   |                                           2                              |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |       1  1              2  1  2                    1  4  1        2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse                 |                               3                       2                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                                                    2                     |             
      Pars Distalis, Cyst                  |                                                    X                     |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Hyperplasia, Nodular  |                         1           1                                    |             
      Pars Nervosa, Inflammation,          |                                                                          |             
          Multifocal, Subacute             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Necrosis, Caseous, Focal             |                                                                          |             
      C-Cell, Hyperplasia                  | 3  2     2  3  3  3                 2  4  3  3        4  4     3  3      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +|             
      Granuloma Sperm                      |                                                             1            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|             
                                           | 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |    3  2     2           2  3        3  1                 1  1     1     1|             
      Inflammation, Chronic Active         |                                  1              3                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +                                         +                        |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                          1               |             
      Necrosis                             |                                                                          |             
      Artery, Inflammation, Chronic        |                               2                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |          4                                               4               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia                 |       3              3  2           2  3        2     2           3  1  1|             
      Femoral, Myelofibrosis               |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                 1                        |             
      Mediastinal, Medulla, Fibrosis       |                      2                                                   |             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
      Sinus, Mandibular, Ectasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                             +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             +            |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Fibrosis, Focal                      |       2                                      2                           |             
      Hematopoietic Cell Proliferation     |                                                             4            |             
      Capsule, Pigmentation, Focal,        |                                                                          |             
          Hemosiderin                      |                                                       1                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  M  M  +  +  +|             
      Ectopic Parathyroid Gland            |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +                 +  +     +           +  +  +  +  +  +  +      |             
      Granuloma                            |       1                                                                  |             
      Hyperplasia, Cystic                  |       3  3                    2     2           2  3  2  3  2  2  1      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                | 1                          1                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|             
                                           | 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                               4                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hindlimb, Inflammation, Subacute     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Hypothalamus, Compression            | 1        3  3                          2                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Mineralization               |                            1                 1                           |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |             1                                                            |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                               2                    1                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      External Ear, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +              +                                       |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
      Lens Crystalline, Cataract           |                   4              1                                       |             
      Posterior Chamber, Inflammation,     |                                                                          |             
           Chronic                         |                   3                                                      |             
      Retina, Atrophy                      |                                  4                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Multifocal              | 1  1  2  4  2  3  3  2  3  2  4  3  1  3  1  3  2  2  4  2  1  3  2  3  1|             
      Renal Tubule, Cytoplasmic Alteration |                      2                                                   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                             +            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Arteriole, Inflammation, Chronic     |                                                                          |      1  3.0|
      Arteriole, Thrombosis                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                               X                    X                     |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    | X  X                                                                     |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +  +|  46        |
      Ulcer                                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  48        |
      Inflammation, Chronic, Focal         |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X                 X                    X  X     X        X        X      |     17  1.0|
      Clear Cell Focus                     |                   X                                               X      |      2     |
      Degeneration, Cystic                 | 1  2                                               1                 1   |      6  1.3|
      Eosinophilic Focus                   |                               X        X                                 |      5     |
      Fatty Change                         |                                           1                              |      3  1.3|
      Mixed Cell Focus                     |                         X                                                |      2     |
      Necrosis, Coagulative, Multifocal    |             3                                                            |      4  1.8|
      Necrosis, Caseous, Focal             |                                                                          |      1  1.0|
      Sinusoid, Angiectasis                |                         2                                                |      1  2.0|
      Sinusoid, Angiectasis, Multifocal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +              +                       +  +              +   |   7        |
      Inflammation, Chronic                |                                                    2                     |      2  1.5|
      Fat, Necrosis                        |                                                                      4   |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      | 1  1              1  1  1        3  3  2  4        3  1  1  1  1         |     27  1.7|
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
      Duct, Concretion                     |                                           4                              |      1  4.0|
      Duct, Ectasia                        |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|  48        |
      Acinus, Submandibular Gland, Atrophy |                                                                          |      1  1.0|
      Parotid Gland, Inflammation, Chronic |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |             3                                      2                     |      3  2.0|
      Arteriole, Submucosa, Thrombosis     |             X                                                            |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium Left, Thrombosis              |                                                                          |      1     |
      Myocardium, Degeneration, Multifocal | 2  2  2  1     1  3     4  4  1  3  2  2  2     2        1  1  2  1      |     39  2.1|
      Myocardium, Fibrosis, Focal          |                                                                          |      1  2.0|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                                                                      1   |      1  1.0|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Myocardium, Inflammation, Multifocal,|                                                                          |            |
           Necrotizing                     |             3                                                            |      1  3.0|
      Valve, Bacterium                     |             X                                                            |      2     |
      Valve, Inflammation, Chronic Active  |             4                                                            |      2  3.5|
      Valve, Thrombosis                    |             X                                                            |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Nodular                 |          1     2        2        2     1        1     1              1  1|     20  1.8|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Nodular                 |             1           3  2                 1        1                  |     14  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Diffuse                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis, Focal    |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                           2                              |      1  2.0|
      Pars Distalis, Hyperplasia, Nodular  |                   1        4                                      2     1|      6  1.7|
      Pars Nervosa, Inflammation,          |                                                                          |            |
          Multifocal, Subacute             |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Necrosis, Caseous, Focal             |             1                                                            |      1  1.0|
      C-Cell, Hyperplasia                  |    2  1  3  3  3  3  2  2  3  2  2  2  3  2  2  2  3  2  3  2  1     1  2|     37  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Granuloma Sperm                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                 3                        |      1  3.0|
      Inflammation, Chronic                |    2        2     1     2  1     2  1  1  2  1  1  2     1     2  1  1  1|     28  1.6|
      Inflammation, Chronic Active         |          3                    3                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Granuloma                            |                                                                   4      |      1  4.0|
      Hemorrhage                           |                                                                      4   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                      +   |   3        |
      Hemorrhage                           |                                                                      4   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  1.0|
      Necrosis                             |                4                                                     4   |      2  4.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |                                  1                                       |      1  1.0|
      Seminiferous Tubule, Atrophy         |                                        4                          4      |      4  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hyperplasia                 |    3  3     4  2              2        4           3        2  1  1  2   |     21  2.3|
      Femoral, Myelofibrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                                                                          |      1  1.0|
      Mediastinal, Medulla, Fibrosis       |                                                                          |      1  2.0|
      Mediastinal, Sinus, Ectasia          |    3                                                                     |      1  3.0|
      Sinus, Mandibular, Ectasia           |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +                                   +  +        +                     |   5        |
      Sinus, Ectasia                       |                                        4  3                              |      2  3.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis, Focal                      |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                        2              1                  |      3  2.3|
      Capsule, Pigmentation, Focal,        |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M|  40        |
      Ectopic Parathyroid Gland            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +           +     +     +  +     +  +           +           +  +     +|  23        |
      Granuloma                            |                                                                          |      1  1.0|
      Hyperplasia, Cystic                  |    2           1     2        1     1  2           2              1     1|     20  1.9|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperkeratosis                       | 2                                                                        |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femur, Fibrous Osteodystrophy        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                      +   |   1        |
      Hindlimb, Inflammation, Subacute     |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |             3  2                                                         |      2  2.5|
      Mineralization, Focal                |    1                                                                     |      1  1.0|
      Hypothalamus, Compression            |       1                          3     1        2                        |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Mineralization               |                                                                          |      2  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                        1                                 |      2  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                +         |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      External Ear, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Eye                                     | +        +  +  +                          +           +        +         |   9        |
      Anterior Chamber, Hemorrhage         |             4                                                            |      1  4.0|
      Lens Crystalline, Cataract           | 1        2  3  3                          4           3        2         |      9  2.6|
      Posterior Chamber, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
      Retina, Atrophy                      | 4        4  4  4                                      4        4         |      7  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                                               +   |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Multifocal              | 3  1  2  1  3  1  2  1  2  2  1  3  3  1  3  2  3  1  1  1  1  1  2  1  2|     50  2.0|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|             
                                           | 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +           +  +  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +           +  A  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +           +  +  +     A     +  +  +     A     +              +  +  +  +|             
      Parasite Metazoan                    |                                                 X                       X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +           +  A  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +           +  +  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +           +  +  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +  A  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +  A  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X           X                 X     X              X     X      |             
      Clear Cell Focus                     |                                              X           X               |             
      Degeneration, Cystic                 |          1                             1                 1               |             
      Eosinophilic Focus                   |          X                                                               |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                  X                                       |             
      Necrosis, Coagulative, Focal         |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                         2     2  2                                       |             
      Centrilobular, Necrosis, Coagulative |                2                                                         |             
      Periportal, Vacuolization Cytoplasmic|             2                                                            |             
      Sinusoid, Angiectasis, Focal         |                                     1                                    |             
      Sinusoid, Angiectasis                |                            1                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +  +      |             
      Fat, Necrosis                        |                                                                4         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Autolysis                            |                                           3                              |             
      Acinus, Atrophy                      | 2              2                 1  2           2                    3  1|             
      Duct, Ectasia                        |                                                 1                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Acinus, Submandibular Gland, Atrophy |                3                                                         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +           +  +  +     +     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +           +  +        +     +  +  +     A     +              +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +           +  A        +     +  +  +     A     +              +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +           +  +  +     +     +  +  +     +  +  +              +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|             
                                           | 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium Left, Thrombosis              |                                              X                           |             
      Myocardium, Degeneration, Multifocal | 2           2  2  1     2     2  2  2     1     3              2  2  3  3|             
      Myocardium, Mineralization, Focal    |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 | 1                    1     2                 3        1                 2|             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   4      |             
      Hyperplasia, Nodular                 |                      2     3     1     2     1  3     1  2     4     1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +           +  +  +     +     +  +  +     +     +     +        +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                                                                          |             
      Pars Distalis, Hyperplasia, Nodular  |                                                       1                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +  A  +     A     +  +  +     A  +  +              +  +  +  +|             
      C-Cell, Hyperplasia                  | 3           1                    3                             2  2     1|             
      Follicle, Dilatation, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +           +  +  +     +  +  +  +  +     +     +              +  M  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 3              2  2     1        1  1           1              2     1  1|             
      Inflammation, Chronic Active         |             2                                                     4      |             
                                            __________________________________________________________________________|             
   Prostate                                | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                            +                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                           3                              |             
      Seminiferous Tubule, Atrophy         |                            2                                         4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +           +  +  +     A     +  +  +     +     +              +  +  +  +|             
      Femoral, Hyperplasia                 | 4              3  2           2  2  3           3                 3  3  3|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Lumbar, Sinus, Ectasia               |                                     4                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|             
                                           | 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                         +     +  +                                +      |             
      Infiltration Cellular, Histiocyte    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +  +  +     +  +  +  +  +  +  +     +              +  +  +  +|             
      Fibrosis, Focal                      |                                                 3                        |             
      Hematopoietic Cell Proliferation     |                               4                                          |             
      Capsule, Fibrosis, Focal             |                                                                          |             
      Red Pulp, Pigmentation, Diffuse,     |                                                                          |             
           Hemosiderin                     |                                           3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +           +  +  +     +     +  +  +     +     +              +  +  M  +|             
      Mediastinum, Inflammation, Chronic,  |                                                                          |             
           Multifocal                      |                                                                2         |             
      Vein, Congestion                     |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +     +           +                 +                    +   |             
      Hyperplasia, Cystic                  |             3     1           2                 2                    2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Hyperkeratosis                       |                1                                                         |             
      Inflammation, Necrotizing            |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Cranium, Inflammation, Chronic, Focal|                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Hemorrhage                           |                                                                   1      |             
      Infarct                              |                                                                          |             
      Hypothalamus, Compression            |             4                                                            |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Congestion                           |                3                          3                              |             
      Alveolus, Hemorrhage                 |                                                                      3   |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                   2                                                      |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|             
                                           | 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Pinna, Inflammation, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Lens Crystalline, Cataract           |             3                                                            |             
      Posterior Chamber, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Retina, Atrophy                      |             4                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Infarct                              |                                                                          |             
      Nephropathy, Multifocal              | 3           3  3  2     1     1  1  1           1              2  1  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +           +  +  +     A     +  +  +     +     +              +  +  +  +|             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6|            |
                                           | 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  25        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +        +  A  +              +     +     +  +  A        +  +  +|  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +        +  +  +              M     +     +  +  +        +  +  +|  24        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +        +  +  +              +     +     +  +  +        +  +  +|  24        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +        +  +  +              +     +     +  +  +        +  +  +|  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  +        +  A  +              +     +     +  +  A        +  +  +|  22        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +  +        +  +  +              +     +     +  +  +        +  +  +|  24        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X        X              X     X  X     X     X           X           X|     17     |
      Clear Cell Focus                     |    X                       X        X                                    |      5     |
      Degeneration, Cystic                 |          2                          1                                    |      5  1.2|
      Eosinophilic Focus                   |                                           X                              |      2     |
      Fatty Change                         | 1                                                                        |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Necrosis, Coagulative, Focal         |                   1                                                      |      1  1.0|
      Necrosis, Coagulative, Multifocal    |                      2                                   1               |      5  1.8|
      Centrilobular, Necrosis, Coagulative |                                                                          |      1  2.0|
      Periportal, Vacuolization Cytoplasmic|                                                                          |      1  2.0|
      Sinusoid, Angiectasis, Focal         |                                                                          |      1  1.0|
      Sinusoid, Angiectasis                |             1                 1  1                                       |      4  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                                          |   3        |
      Fat, Necrosis                        |                               4                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Autolysis                            |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                   1  1  2              2              1  1           2   |     14  1.6|
      Duct, Ectasia                        |                                              2                           |      2  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Acinus, Submandibular Gland, Atrophy |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +        +  +  +  +           +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +        +  +  +  +           +     +     +  +  +        +  +  +|  26        |
      Edema                                |                                              3                           |      1  3.0|
      Ulcer                                |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +        +  +  +  +           +     +     +  +  +        +  +  +|  25        |
      Edema                                |                                              3                           |      1  3.0|
      Ulcer                                |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6|            |
                                           | 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +        +  +  +              +     +     +  +  +        +  +  +|  28        |
      Atrium Left, Thrombosis              |                                                                          |      1     |
      Myocardium, Degeneration, Multifocal |       2              3  1                    3           1        1  3  3|     22  2.1|
      Myocardium, Mineralization, Focal    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Nodular                 |                         1                    1  2     4                  |     10  1.8|
      Hypertrophy, Focal                   |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  4.0|
      Hyperplasia, Nodular                 | 2     1              3     1     1  3  1  1  1     3  1     1  1     1  1|     25  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +        +  M  +              +     +     +  +  +        +  +  +|  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +  +  +  +     +        +  +  +     +  +  +  +     +  +  +|  34        |
      Pars Distalis, Angiectasis, Focal    |    3                                                                     |      1  3.0|
      Pars Distalis, Hyperplasia, Nodular  |                                                                         2|      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +        +  +  +              +     +     +  +  +        +  +  +|  26        |
      C-Cell, Hyperplasia                  |       2  2        3     2                             2  1           2   |     13  2.0|
      Follicle, Dilatation, Focal          |                                                          1               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Hyperplasia                          |                      4                                                   |      1  4.0|
      Inflammation, Chronic                |       2                 1              1           1     1        1  2  1|     18  1.4|
      Inflammation, Chronic Active         |          1           3                       3                           |      5  2.6|
                                            __________________________________________________________________________|____________|
   Prostate                                |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6|            |
                                           | 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  3.0|
      Seminiferous Tubule, Atrophy         |          4                    4     4        4  4           4     4      |      9  3.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +        +  +  +              +     +     +  +  +        +  +  +|  26        |
      Femoral, Hyperplasia                 |       2  2        2     2              2           3  4           2  2  2|     20  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Lumbar, Sinus, Ectasia               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +                                         +                     |   7        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +     +  +  +  +              +     +     +  +  +  +     +  +  +|  33        |
      Fibrosis, Focal                      | 3                                                                        |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Capsule, Fibrosis, Focal             |                                                          3               |      1  3.0|
      Red Pulp, Pigmentation, Diffuse,     |                                                                          |            |
           Hemosiderin                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  M        M  +  +              +     +     +  +  M        +  +  +|  23        |
      Mediastinum, Inflammation, Chronic,  |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Vein, Congestion                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +     +        +     +                    +     +  +                  |  12        |
      Hyperplasia, Cystic                  |          3        3     3                    4     4  1                  |     11  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +     +  +  +  +              +     +     +  +  +        +  +  +|  29        |
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Inflammation, Necrotizing            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Cranium, Inflammation, Chronic, Focal|                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Infarct                              |                      4                 4                 4        3      |      4  3.8|
      Hypothalamus, Compression            |                         1                    4     3                     |      4  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6|            |
                                           | 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Congestion                           |                                                                          |      2  3.0|
      Alveolus, Hemorrhage                 |                                                                          |      1  3.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                         2                             2              1   |      3  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                    +                     |   1        |
      Pinna, Inflammation, Necrotizing     |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                   +                              |   3        |
      Lens Crystalline, Cataract           |                                           4                              |      2  3.5|
      Posterior Chamber, Inflammation,     |                                                                          |            |
           Chronic                         |       4                                   3                              |      2  3.5|
      Retina, Atrophy                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +        +  +  +  +           +     +     +  +  +        +  +  +|  28        |
      Infarct                              |          3                                                               |      1  3.0|
      Nephropathy, Multifocal              |       1  1        1  2  2  3                 3     3  1  1        1  1  2|     26  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  26        |
      Dilatation                           |                                                          4               |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|             
                                           | 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +           +        +  +  +        +           +        +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    A           +        +  +  +        A           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    A           +        +  +  +        A           +        +     +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    A           +        M  +  +        A           +        +     +  A  +|             
      Diverticulum                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    A           +        +  +  +        A           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A           +        +  +  +        A           +        +     +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A           +        +  +  +        A           +        +     +  A  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X                 X  X     X     X  X        X  X     X  X      |             
      Clear Cell Focus                     | X           X                    X  X     X  X           X     X         |             
      Degeneration, Cystic                 |          2     1                                1        1               |             
      Eosinophilic Focus                   |          X                                      X     X                  |             
      Fatty Change                         |                                                                          |             
      Necrosis, Coagulative, Focal         |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Regeneration, Focal                  |                                                                          |             
      Centrilobular, Cytomegaly            |       1                          1        1  1        1  1     1  1      |             
      Centrilobular, Necrosis, Coagulative |                                        3                                 |             
      Sinusoid, Angiectasis, Focal         |                               1                                          |             
      Sinusoid, Angiectasis                | 1                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +              +      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    A  +        +        +  +  +        +           +        +     +  A  +|             
      Acinus, Atrophy                      |                3        2  3           1                    2            |             
      Acinus, Hypertrophy, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    A           +        +  +  +        +           +        +     +  +  +|             
      Autolysis                            |                                                                      4   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    A           +        +  +  +        +           +        +     +  A  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +           +        +  +  +        +           +        +     +  +  +|             
      Dilatation                           |                                                                          |             
      Atrium, Dilatation                   |                               3        4                                 |             
      Atrium Left, Thrombosis              |                X                                                         |             
      Myocardium, Degeneration, Multifocal |    2           3           2  2        2                    2        2  2|             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                                             2            |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|             
                                           | 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia, Nodular                 | 3     1              1     2  4  2                                       |             
      Hypertrophy, Focal                   |                                                 1                        |             
      Mineralization, Multifocal           |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |       2        1  2  1     1  2  2  3     2     1  2        2     1  3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +           +        +  +  +        +           +        +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +     +        +  +  +        +        +  +     +  I     +  +  +|             
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  A           +        +  +  +        A           +        +     +  A  A|             
      C-Cell, Hyperplasia                  |                2              1                    1        3            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +           +        +  +  +        +           +        +     +  +  +|             
      Inflammation, Chronic                |                                                    2                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +           +        +     +        +           +        +     +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |    2           1        3              2           1        2     1  2  3|             
      Inflammation, Chronic Active         |                               3                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +           +        +  +  +        +           +        +     +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                                      1  1|             
      Seminiferous Tubule, Atrophy         |          4           4                          4     4  4     4     4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +           +        +  +  +        +           +        +     +  A  +|             
      Femoral, Hyperplasia                 |                4        3  2                       3        3     1      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +        +  +  +        +     +     +        +     +  +  +|             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
      Sinus, Mandibular, Ectasia           |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                         +     +                                          |             
      Sinus, Ectasia                       |                               1                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    A           +  +  +  +  +  +  +  +  +  +  +     +        +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|             
                                           | 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis, Focal                      |                                  1        3  3                           |             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +           +        +  +  +        +           +        +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +           +                                         +   |             
      Hyperplasia, Cystic                  |                3           1                                         1   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +        +  +  +        +        +  +  +     +     M  +  +|             
      Cyst Epithelial Inclusion            |                               X                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                                                       3                  |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +     +        +  +  +        +           +        +     +  +  +|             
      Tibia, Fracture Healed               |          X                                                               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +           +        +  +  +        +           +        +     +  +  +|             
      Infarct                              |                                                    1                     |             
      Hypothalamus, Compression            |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +           +        +  +  +        +           +        +     +  +  +|             
      Bacterium                            |    X                                                                     |             
      Congestion                           |    3                                   2                                 |             
      Alveolus, Hemorrhage                 |    3           2        1                          1                     |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                                                                   1      |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +           +        +  +  +        +           +        +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +           +        +  +  +        +           +        +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Anterior, Synechia                   |                                                                          |             
      Lens Crystalline, Cataract           |                4                                                         |             
      Retina, Atrophy                      |                4                                                         |             
      Sclera, Mineralization, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|             
                                           | 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +           +        +  +  +        +           +        +     +  +  +|             
      Nephropathy, Multifocal              |                2        1  3  2        2           2        2     1  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    A           +        +  +  +        +           +        +     +  A  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5|            |
                                           | 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +  +  +                                   +           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +           +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +  +  +                                   +           +  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +           +  +  +                                   +           +  +|  14        |
      Diverticulum                         |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +  +  +                                   +           +  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +  +  +                                   +           +  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +  +  +                                   +           +  +|  13        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |    X  X     X     X     X        X     X  X  X     X     X  X  X  X      |     24     |
      Clear Cell Focus                     |                               X        X                                 |     10     |
      Degeneration, Cystic                 |       1  1                 1                 1                 2         |      9  1.2|
      Eosinophilic Focus                   |                                                       X     X            |      5     |
      Fatty Change                         |                                                                      3   |      1  3.0|
      Necrosis, Coagulative, Focal         |          1                                                  1            |      2  1.0|
      Necrosis, Coagulative, Multifocal    |                                                          1               |      1  1.0|
      Regeneration, Focal                  |                            3                                             |      1  3.0|
      Centrilobular, Cytomegaly            | 1  1  1     1     1     1     1  1  1  1  1  1  1     1     1           1|     24  1.0|
      Centrilobular, Necrosis, Coagulative |                                                                2         |      2  2.5|
      Sinusoid, Angiectasis, Focal         |                                                                          |      1  1.0|
      Sinusoid, Angiectasis                |                            3                                   2         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +  +  +                                   +           +  +|  16        |
      Acinus, Atrophy                      |                2  3  2                                   1           2  2|     11  2.1|
      Acinus, Hypertrophy, Focal           |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +  +  +                                   +           +  +|  16        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +  +                                   +           +  +|  15        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +           +  +  +                                   +           +  +|  18        |
      Dilatation                           |                                                          3               |      1  3.0|
      Atrium, Dilatation                   |                                                                          |      2  3.5|
      Atrium Left, Thrombosis              |                                                                          |      1     |
      Myocardium, Degeneration, Multifocal |    1           2  3  3                                               2  3|     14  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5|            |
                                           | 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                   1                                                      |      2  1.5|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                          2               |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Nodular                 |                   3              4  3              3        2        1  1|     13  2.3|
      Hypertrophy, Focal                   |    1                                                                     |      2  1.0|
      Mineralization, Multifocal           |                                     1                                    |      1  1.0|
      Vacuolization Cytoplasmic, Focal     |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Nodular                 | 1     1  3        1        2        1           1  1  2     2     2     1|     26  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +  +  +                                   +           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +  +  +              +                    +           +  +|  20        |
      Pars Distalis, Hyperplasia, Nodular  |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +  +                                   +           +  +|  14        |
      C-Cell, Hyperplasia                  |                3     1                                               2   |      7  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                  +                                       |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                +  +  +                                   +           +  +|  17        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +  +  +           +                       +        +  +  +|  18        |
      Hyperplasia                          |                                                                   3      |      1  3.0|
      Inflammation, Chronic                |                1  1  3                                   1           2  3|     15  1.9|
      Inflammation, Chronic Active         |                                                                   2      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                |                +  +  +                                   +           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |                                                                          |      2  1.0|
      Seminiferous Tubule, Atrophy         | 4        4              4  3  4     4                 4     4            |     15  3.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +  +  +                                   +           +  +|  16        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5|            |
                                           | 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Femoral, Hyperplasia                 |                4  2                                      3           3  2|     11  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +     +  +  +                                   +           +  +|  19        |
      Mandibular, Hyperplasia, Lymphoid    |                   4                                                      |      1  4.0|
      Mediastinal, Hyperplasia, Lymphoid   |                   4                                                      |      1  4.0|
      Mediastinal, Sinus, Ectasia          |                                                          2               |      1  2.0|
      Sinus, Mandibular, Ectasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                      +                                   +               |   4        |
      Sinus, Ectasia                       |                                                          3               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +     +  +  +     +  +  +           +        +  +        +  +  +|  29        |
      Fibrosis, Focal                      |                                                                          |      3  2.3|
      Hematopoietic Cell Proliferation     |                      4                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +  +  M                                   +           +  M|  15        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +  +                          +     +                 +   |   8        |
      Hyperplasia, Cystic                  |                2                                                     3   |      5  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +                                +     +     +  +|  20        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Chronic                |                                                          2               |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Thrombosis                           |                                                          X               |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +  +                                   +           +  +|  18        |
      Tibia, Fracture Healed               |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +  +  +                                   +           +  +|  17        |
      Infarct                              |                4                                                         |      2  2.5|
      Hypothalamus, Compression            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +  +  +                                   +  +        +  +|  18        |
      Bacterium                            |                                                                          |      1     |
      Congestion                           |                                                                          |      2  2.5|
      Alveolus, Hemorrhage                 |                                                                          |      4  1.8|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5|            |
                                           | 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Focal                           |                1                                                         |      2  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +  +  +                                   +           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +  +  +                                   +           +  +|  17        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                    +     +  +                          +         |   6        |
      Anterior, Synechia                   |                                  3                                       |      1  3.0|
      Lens Crystalline, Cataract           |       4                    3     3  2                          1         |      6  2.8|
      Retina, Atrophy                      |       4                    4     4  3                          3         |      6  3.7|
      Sclera, Mineralization, Multifocal   |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +     +  +  +                                   +  +  +     +  +|  21        |
      Nephropathy, Multifocal              |       4  3     2  1  1                                   2  3  4     1  3|     20  2.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +  +  +                                   +           +  +|  15        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|             
                                           | 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +  +              +  +        +        +  +  +        A        +|             
      Inflammation, Chronic, Focal         |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     M  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +  +              +  +        +        +  +  +        A        +|             
      Parasite Metazoan                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +  +              +  +        +        +  +  +        A        +|             
      Inflammation, Necrotizing            |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X     X     X        X     X        X              X        X  X   |             
      Clear Cell Focus                     |                X     X  X  X              X                              |             
      Degeneration, Cystic                 |             1                                                            |             
      Eosinophilic Focus                   | X                                                                 X  X   |             
      Fatty Change                         |                                                                2         |             
      Necrosis, Coagulative, Multifocal    |                                                                          |             
      Centrilobular, Cytomegaly            |       1  1              2  1     2                 1              1  1   |             
      Centrilobular, Hemorrhage            |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                                                                3         |             
      Centrilobular, Necrosis, Caseous     |                                                       3                  |             
      Sinusoid, Angiectasis                |             1                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +           +                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +  +              +  +        +     +  +  +  +        A        +|             
      Acinus, Atrophy                      |    2        1              2                    3     1                  |             
      Acinus, Hyperplasia                  |                                                 3                        |             
      Artery, Inflammation, Chronic        |                                              4                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +  +              +  +        +        +  +  +        +        +|             
      Ulcer                                |                                                                         4|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +  +              +  +        +  +     +  +  +        +        +|             
      Atrium Left, Thrombosis              |                                                                         X|             
      Mitral Valve, Thrombosis             |    X                                                                     |             
      Myocardium, Degeneration, Multifocal |    3     1  2              3           1        2  2           2        1|             
      Myocardium, Inflammation, Chronic    |                                                                          |             
          Active, Multifocal               |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|             
                                           | 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                                       1                  |             
      Hyperplasia, Nodular                 |    2  1     2     2  1  2  1  3  1  1  1     1  1  1     2              2|             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +     +        +  +        +        +  +  +     +  +     +  +|             
      Pars Distalis, Cyst                  |                                                             X        X   |             
      Pars Distalis, Hyperplasia, Nodular  |    1                                                                    1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +  +              +  +        +        +  +  +        A        +|             
      C-Cell, Hyperplasia                  |    2     3  1              2           2        2  4  4                 3|             
      Follicle, Dilatation, Multifocal     |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     M  +        +     +  +        +        +  +  +        +        +|             
      Inflammation, Chronic                |    1                 3     2  2        2        2  2  3        1         |             
      Inflammation, Chronic Active         |             2                                                           3|             
      Duct, Ectasia                        |                      3                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                4     4           4              4        4     2        4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +              +  +        +        +  +  +        A        +|             
      Femoral, Hyperplasia                 |    2     3  1                 3        3        2  3                    2|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +              +  +        +        +  +  +        +        +|             
      Mandibular, Inflammation, Necrotizing|                                                                          |             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                        +                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                        +                                 |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +              +  +  +  +  +        +  +  +  +  +  +        +|             
      Fibrosis, Diffuse                    |                                                       2                  |             
      Fibrosis, Focal                      |                                                          2               |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +              +  +        +        +  +  +        +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|             
                                           | 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +        +                 +                                          |             
      Hyperplasia, Cystic                  |    2                          2                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +           +  +  +     +        +  +  +  +     +        +|             
      Acanthosis                           |                                  3                                       |             
      Fungus                               |                                  X                                       |             
      Hyperkeratosis                       |       1                                                                  |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +              +  +        +        +  +  +        +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +  +              +  +        +        +  +  +        +        +|             
      Hypothalamus, Compression            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +  +              +  +        +        +  +  +        +        +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Artery, Mineralization               |          1                                            1                  |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                 1     2                  |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +  +              +  +        +  +     +  +  +        +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                            +                        |             
      Lens Crystalline, Cataract           |    2                                            3                        |             
      Posterior Chamber, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Retina, Atrophy                      |    3                                            4                        |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +  +              +  +        +  +  +  +  +  +  +     +        +|             
      Nephropathy, Multifocal              |    2     2  3              2  2        2  3  3  2  1  1        1        4|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +  +              +  +        +        +  +  +        A        +|             
      Mucosa, Inflammation, Proliferative  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4|            |
                                           | 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
      Inflammation, Necrotizing            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X  X                                      X  X                       X|     15     |
      Clear Cell Focus                     |                      X  X              X                                 |      8     |
      Degeneration, Cystic                 |                               2           1                              |      3  1.3|
      Eosinophilic Focus                   |                   X                       X                          X   |      6     |
      Fatty Change                         |                                                                          |      1  2.0|
      Necrosis, Coagulative, Multifocal    |                1                                                         |      1  1.0|
      Centrilobular, Cytomegaly            |    1  2           1                    1  1                              |     13  1.2|
      Centrilobular, Hemorrhage            |                                     4                                    |      1  4.0|
      Centrilobular, Necrosis, Coagulative |                                                          1               |      2  2.0|
      Centrilobular, Necrosis, Caseous     |                                                                          |      1  3.0|
      Sinusoid, Angiectasis                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +  +                    +  +     +  +     +  +        +  +  +   |  23        |
      Acinus, Atrophy                      | 2                                2  3     1  2     2           2     1   |     13  1.8|
      Acinus, Hyperplasia                  |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Ulcer                                |                                                                4         |      2  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  25        |
      Atrium Left, Thrombosis              |                                  X                       X               |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4|            |
                                           | 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Mitral Valve, Thrombosis             |                                                                          |      1     |
      Myocardium, Degeneration, Multifocal | 3        1                          4     2           2        2     2   |     16  2.1|
      Myocardium, Inflammation, Chronic    |                                                                          |            |
          Active, Multifocal               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Nodular                 |       1        1  1                                   1     1     3  1  2|      8  1.4|
      Inflammation, Necrotizing            |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Hyperplasia, Nodular                 |       1           1  2              3     2     2           1  1         |     24  1.5|
      Inflammation, Necrotizing            |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +  +  +                 +  +     +  +     +  +  +  +  +  +  +  +|  31        |
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia, Nodular  |             1                                      2                     |      4  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | A        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
      C-Cell, Hyperplasia                  |             3                    3        2  4     3  2           2  2   |     17  2.6|
      Follicle, Dilatation, Multifocal     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Inflammation, Chronic                | 1        2  3                    2  2        1     3  2  2     1  2  1   |     21  1.9|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |  48        |
      Seminiferous Tubule, Atrophy         |       4        4  4  4                 3                                 |     12  3.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
      Femoral, Hyperplasia                 | 4                                4        3  3     3  2  2               |     15  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4|            |
                                           | 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +                 +  +     +  +     +  +  +     +  +  +   |  26        |
      Mandibular, Inflammation, Necrotizing|                                     2                                    |      1  2.0|
      Mediastinal, Sinus, Ectasia          |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                           +  +                           |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +                             +        +  +                           |   5        |
      Sinus, Ectasia                       |    4                             2                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +  +              +  +  +     +  +     +  +  +  +  +  +  +   |  31        |
      Fibrosis, Diffuse                    |                                                                          |      1  2.0|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +        +  +                    +  +     +  +     +  +  +     M  +  +   |  23        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +                                +        +           +      |   7        |
      Hyperplasia, Cystic                  |             1                                         4           2      |      5  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +  +     +     +  +     +  +     +  +     +  +  +     +  +  +   |  31        |
      Acanthosis                           |                                                                          |      1  3.0|
      Fungus                               |                                                                          |      1     |
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                      2   |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  25        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Hypothalamus, Compression            |                                                       4        2  4      |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Alveolar Epithelium, Hyperplasia     |                                                                2         |      1  2.0|
      Alveolus, Hemorrhage                 |                                  2  3              2                     |      3  2.3|
      Artery, Mineralization               |                                                                          |      2  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  25        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4|            |
                                           | 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                       +|   4        |
      Lens Crystalline, Cataract           | 4                                                                       4|      4  3.3|
      Posterior Chamber, Inflammation,     |                                                                          |            |
           Chronic                         | 3                                                                       3|      2  3.0|
      Retina, Atrophy                      |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +  +                    +  +     +  +  +  +  +  +     +  +  +   |  28        |
      Nephropathy, Multifocal              | 1           2                    4  2     2  2  3  2  3  2     3  3  1   |     26  2.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
      Mucosa, Inflammation, Proliferative  |                                                                   3      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|             
                                           | 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Parasite Metazoan                    |                         X                       X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Peyer's Patch, Inflammation,         |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Basophilic Focus                     |    X        X        X        X           X        X     X           X  X|             
      Clear Cell Focus                     |             X                 X  X        X                              |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   | X  X        X        X     X                                         X   |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Mixed Cell Focus                     |                                                    X                     |             
      Regeneration, Focal                  |                                                                          |             
      Regeneration, Multifocal             |                                                                          |             
      Centrilobular, Cytomegaly            | 1           1     1        1     1        1           1  1               |             
      Centrilobular, Necrosis, Coagulative |          4                                                               |             
      Sinusoid, Angiectasis                |                                                    2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                 +           +                          +               |             
      Fat, Necrosis                        | 4                             4                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  A     +  +     +           +     +     +        +  +  A  +  +  +|             
      Acinus, Atrophy                      |       3        1        1                       2           1           2|             
      Artery, Inflammation, Chronic        |                         2                                            2   |             
      Duct, Ectasia                        |                                                                      4   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  M     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Ulcer                                |                                                                          |             
      Mucosa, Mineralization, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                        +              +                  |             
      Cyst                                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
      Infarct                              |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|             
                                           | 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Dilatation                   |                                                                          |             
      Atrium Left, Thrombosis              |    X              X                                                      |             
      Endocardium, Proliferation           |                                                                          |             
      Myocardium, Degeneration, Multifocal |    2  1  3     2  1                       2     2        1  1  2  2     2|             
      Valve, Bacterium                     |          X                                                               |             
      Valve, Thrombosis                    |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Nodular                 |          2                 2     1     1        1                    2   |             
      Hypertrophy, Focal                   |                      1        3                                          |             
      Necrosis, Coagulative, Diffuse       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Nodular                 | 1  1  3     2  2        1     1     1        2  1        2  2     1      |             
      Necrosis, Coagulative, Diffuse       |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  M     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +     +  +     +           +     +     +        +  +  A  +     +|             
      Pars Distalis, Angiectasis, Focal    |                   2                                                      |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Nodular  |                   1                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  M     +  +     +  +  +     +     +     +        +  +  A  +     +|             
      C-Cell, Hyperplasia                  |    3  2        2  3     2                 2     3        2  2     2     3|             
      Follicle, Dilatation, Multifocal     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +     +  +     +           +     +     +        M  +  A  +     +|             
      Granuloma Sperm                      |                         1                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +     +  +     +           +     +  +  +     +  +  +  +  +     +|             
      Autolysis, Diffuse                   |                                                                3         |             
      Inflammation, Chronic                |    1     2     1  2                 1     1     3     2     2  2  1     2|             
      Inflammation, Chronic Active         |       3                                                                  |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis, Diffuse                   |                                                                3         |             
      Seminiferous Tubule, Atrophy         |    4  4                 3  4                 3     4                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +     +  +     +           +     +     +        +  +  A  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|             
                                           | 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Hyperplasia                 |       3        4        3           3     1              3  3     2      |             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  M     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +        +        +                                +               |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +     +           +  +  +  +  +        +  +  A  +  +  +|             
      Fibrosis, Focal                      | 1  2                                                                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +     +  +     +           +     +     +        +  +  A  +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +           +  +                 +           +           +           +|             
      Hyperplasia, Cystic                  |    3           2                    1           2           1           4|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Tail, Necrosis, Coagulative, Diffuse |                                     4                                    |             
      Tail, Dermis, Epidermis, Bacterium   |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
      Femur, Osteopetrosis                 |                                     3                                    |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
      Abscess                              |                                                                   3      |             
      Artery, Bacterium                    |          X                                                               |             
      Cerebellum, Neuron, Necrosis, Focal  |                                                                          |             
      Hypothalamus, Compression            |                                                 4                       3|             
      Ventricle, Hydrocephalus             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +     +  +     +           +     +  +  +        +  +  +  +     +|             
      Alveolus, Hemorrhage                 |                                                 2                        |             
      Alveolus, Hemorrhage, Multifocal     |                                              1                           |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |    1                                                                     |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|             
                                           | 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
      Middle Ear, Inflammation, Chronic    |                                                                          |             
      Pinna, Inflammation, Necrotizing     |                                                    4                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Lens Capsule, Cataract               |                                                                          |             
      Lens Crystalline, Cataract           |                      4                                                   |             
      Posterior Chamber, Inflammation,     |                                                                          |             
           Chronic                         |                      3                                                   |             
      Sclera, Mineralization, Multifocal   |                      2                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
      Inflammation, Chronic, Multifocal    |                                                                   1      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +     +  +     +     +     +     +     +  +     +  +  +  +     +|             
      Hemorrhage, Focal                    |                                                                4         |             
      Inflammation, Multifocal, Necrotizing|          4                                                               |             
      Nephropathy, Multifocal              |    2  3        2  1     2     4     2     4     3  3        1     2     1|             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
      Renal Tubule, Bacterium              |          X                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Inflammation, Acute                  |                                                                          |             
      Lamina Propria, Edema                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Parasite Metazoan                    |                         X                                                |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Peyer's Patch, Inflammation,         |                                                                          |            |
          Suppurative                      |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |             X                 X  X                                       |     12     |
      Clear Cell Focus                     |             X                                      X                     |      6     |
      Degeneration, Cystic                 |       1        2              1           1           1                  |      5  1.2|
      Eosinophilic Focus                   |                            X  X                                          |      8     |
      Fatty Change                         | 3                                   3  3                                 |      3  3.0|
      Hepatodiaphragmatic Nodule           |                                                                   X      |      1     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Regeneration, Focal                  |                                                       1        2         |      2  1.5|
      Regeneration, Multifocal             |                                                          4               |      1  4.0|
      Centrilobular, Cytomegaly            |          1  1                 1  1                 2        1            |     14  1.1|
      Centrilobular, Necrosis, Coagulative |                                                                          |      1  4.0|
      Sinusoid, Angiectasis                |                                                                1        1|      3  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                 +                                   +               |   7        |
      Fat, Necrosis                        |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
      Acinus, Atrophy                      | 2  3                    1  1        1  1  1  1  2        2        1      |     17  1.5|
      Artery, Inflammation, Chronic        |                                                                          |      2  2.0|
      Duct, Ectasia                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
      Ulcer                                | 4                                   4  4                                 |      3  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Ulcer                                |                      2                                                   |      1  2.0|
      Mucosa, Mineralization, Multifocal   |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
      Infarct                              |                                                                          |      1  2.0|
      Atrium, Dilatation                   |                   4                                                      |      1  4.0|
      Atrium Left, Thrombosis              |                                                                          |      2     |
      Endocardium, Proliferation           |                                                                   1      |      1  1.0|
      Myocardium, Degeneration, Multifocal | 2  1              2  1     1        1  1  2  2  2     1  3           1   |     25  1.6|
      Valve, Bacterium                     |                                                                          |      1     |
      Valve, Thrombosis                    |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  47        |
      Hyperplasia, Nodular                 |          1     2                 1                       3               |     10  1.6|
      Hypertrophy, Focal                   |                                                             2            |      3  2.0|
      Necrosis, Coagulative, Diffuse       |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Nodular                 | 1     2  2  2  2        1  1  2  2     3  2     1  1  2  2        4  1   |     30  1.7|
      Necrosis, Coagulative, Diffuse       |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +        +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +              +  +  +  +        +  +  +  +  +     +  M        +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +              +  +  +  +     +  +  +  +  +  +     +  +  +     +  +   |  30        |
      Pars Distalis, Angiectasis, Focal    |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |    X                                                                     |      1     |
      Pars Distalis, Hyperplasia, Nodular  |                                              1                    2      |      3  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +              +  +  +  A        +  +  +  +  +     +  +        +  A   |  27        |
      C-Cell, Hyperplasia                  |    2              2  2              4     2  2  2                 4      |     19  2.4|
      Follicle, Dilatation, Multifocal     |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
      Granuloma Sperm                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +        +     +  +  +  +        +  +  +  +  +     +  +     +  +  +   |  33        |
      Autolysis, Diffuse                   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                | 3  2        4     2  2  1  2        1     2  1           2        1  2   |     25  1.8|
      Inflammation, Chronic Active         |                                        4        3     2                  |      4  3.0|
      Duct, Ectasia                        |             4                          4                                 |      2  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Autolysis, Diffuse                   |                                                                          |      1  3.0|
      Seminiferous Tubule, Atrophy         |             3     4              4           4     4     4     4         |     13  3.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
      Femoral, Hyperplasia                 |    3                 4  4  2              3           3  3        3      |     16  2.9|
      Femoral, Myelofibrosis               |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +              +  +  +  +     +  +  +  +  +  +     +  +     +  +  +   |  29        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +  +                          +        +               |   8        |
      Sinus, Ectasia                       |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +  +  +        +  +  +  +  +     +  +     +  +  +   |  35        |
      Fibrosis, Focal                      |                   3                                                      |      3  2.0|
      Hematopoietic Cell Proliferation     |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                   +  +        +  +  +  +               |  14        |
      Hyperplasia, Cystic                  | 4                                   2  2        1     3  2               |     12  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
      Subcutaneous Tissue, Edema           |                                                 4                        |      1  4.0|
      Tail, Necrosis, Coagulative, Diffuse |                                                                          |      1  4.0|
      Tail, Dermis, Epidermis, Bacterium   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
      Femur, Osteopetrosis                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
      Abscess                              |                                                                          |      1  3.0|
      Artery, Bacterium                    |                                                                          |      1     |
      Cerebellum, Neuron, Necrosis, Focal  |                   1                                                      |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hypothalamus, Compression            | 3                                   4  3                                 |      5  3.4|
      Ventricle, Hydrocephalus             |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  30        |
      Alveolus, Hemorrhage                 |                                                                          |      1  2.0|
      Alveolus, Hemorrhage, Multifocal     |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +                                             |   2        |
      Middle Ear, Inflammation, Chronic    |                            2                                             |      1  2.0|
      Pinna, Inflammation, Necrotizing     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |             +  +                                                         |   3        |
      Lens Capsule, Cataract               |                2                                                         |      1  2.0|
      Lens Crystalline, Cataract           |             3                                                            |      2  3.5|
      Posterior Chamber, Inflammation,     |                                                                          |            |
           Chronic                         |             3                                                            |      2  3.0|
      Sclera, Mineralization, Multifocal   |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic, Multifocal    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  31        |
      Hemorrhage, Focal                    |                                                                          |      1  4.0|
      Inflammation, Multifocal, Necrotizing|                                                                          |      1  4.0|
      Nephropathy, Multifocal              | 4  1              1  4  2  2        3  4  4  1  1     3  1        2  1   |     28  2.3|
      Pelvis, Inflammation, Suppurative    |                   3                                                      |      1  3.0|
      Renal Tubule, Bacterium              |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
      Inflammation, Acute                  |                                                                      3   |      1  3.0|
      Lamina Propria, Edema                |                   2                                                      |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|             
                                           | 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  A  A  +        +  +        +     A  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
      Parasite Metazoan                    |       X                                            X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +  A  +        +  +        +     A  +  +  +     +  +  +     +|             
      Ulcer                                |                                                                   1      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  A  A  +        +  +        +     A  +  +  +     +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
      Ulcer                                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +  A  +        +  +        +     A  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X              X  X        X  X  X        X     X  X           X  X|             
      Clear Cell Focus                     |    X  X                                                                  |             
      Congestion                           |                                              2                           |             
      Degeneration, Cystic                 | 1                                                                        |             
      Eosinophilic Focus                   |                               X     X     X           X                  |             
      Fatty Change                         |             1                                                     2      |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Mixed Cell Focus                     |                                     X     X           X                  |             
      Necrosis, Coagulative, Focal         |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                2                                                         |             
      Regeneration, Focal                  | 2                                                                        |             
      Centrilobular, Cytomegaly            |    1     1        1  1  1     1  1  1  1  1        1  1  1           1  1|             
      Sinusoid, Angiectasis                |                                  1                    1                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
      Acinus, Atrophy                      |       1           1        2                 2     2  1        2  1      |             
      Artery, Inflammation, Acute          |                                                       2                  |             
      Artery, Inflammation, Chronic        |                                              1     3                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
      Epithelium, Acanthosis, Diffuse      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Atrium Left, Thrombosis              |                                                       X           X      |             
      Myocardium, Degeneration, Multifocal |       3  3  1  2  3           2        2     3  3  2  3     1  3  2     2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|             
                                           | 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |          1                    3                 2  2     2               |             
      Hypertrophy, Focal                   |                                  2                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 | 3  1                    2  1     2              2  2        2  2  2     1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
      Pars Distalis, Hyperplasia, Nodular  |                   1                                   1                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  A  A  +        +  +        +     A  +  +  +     +  +  +     +|             
      C-Cell, Hyperplasia                  |       3  3        2        2           2           2  2     2     1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Hyperplasia                          |                                                    3                     |             
      Inflammation, Chronic                |       1  2     1  3        1           1     1  2     2     2  2         |             
      Inflammation, Chronic Active         |             1                                      3              3     2|             
      Duct, Ectasia                        |                                                                         2|             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Granuloma                            |                               2                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |       4                          4                    2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Femoral, Hyperplasia                 |          2                 3  2        2        2  3  2     4     4     2|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  A  +        +  +        +        +  +  +  +  +  +  +  +  +|             
      Mandibular, Hyperplasia, Plasma Cell |                                                          3               |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Sinus, Ectasia          |                                                                2         |             
      Sinus, Mandibular, Ectasia           |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                               +                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +                                      +   |             
      Sinus, Ectasia                       |                                                                      2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|             
                                           | 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                               1                                          |             
      Necrosis, Focal                      |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +  +  +        +  +        +     +  M  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +                    +                 +                           |             
      Hyperplasia, Cystic                  |       2                    1                 1                           |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Hypothalamus, Compression            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Congestion                           |             4                                3                           |             
      Interstitium, Hemorrhage, Chronic,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                        1                    2            |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Sinus, Inflammation, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +        +               |             
      Pinna, Acanthosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                  +               |             
      Lens Crystalline, Cataract           |       3                                                                  |             
      Posterior Chamber, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Retina, Atrophy                      |       3                                                                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +  +        +  +        +     +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Multifocal              |       2  2     1  2        3  2              1  1  2  3  3  2  2  3  3  1|             
      Renal Tubule, Cyst                   |                                                          X               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  M  A  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|             
                                           | 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Focal, Squamous                 |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4|            |
                                           | 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +     +  +  +  +              +     +        +     +     +  +      |  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  23        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  22        |
      Ulcer                                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    A  +     +  +  +  A           A  +     A        +     +     +  +      |  23        |
      Inflammation, Necrotizing            |             4                                                            |      1  4.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    A  +        +  +  A           A  +     A        +     +     +  +      |  22        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     | X        X     X        X  X  X        X  X  X  X  X  X  X  X            |     26     |
      Clear Cell Focus                     |                               X                                          |      3     |
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                1                                                         |      2  1.0|
      Eosinophilic Focus                   |                X        X                    X  X        X  X           X|     11     |
      Fatty Change                         |                      1                                                   |      3  1.3|
      Hepatodiaphragmatic Nodule           |             X                                                            |      1     |
      Mixed Cell Focus                     | X        X                                                               |      5     |
      Necrosis, Coagulative, Focal         |                                                                   1      |      1  1.0|
      Necrosis, Coagulative, Multifocal    |                                                                          |      1  2.0|
      Regeneration, Focal                  |                   1                                                      |      2  1.5|
      Centrilobular, Cytomegaly            | 1     1  1     1        1  1  1     1  1     1  1  1                 1  1|     29  1.0|
      Sinusoid, Angiectasis                |                            1                                1           1|      5  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   2        |
      Fat, Necrosis                        |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  25        |
      Acinus, Atrophy                      |       2     1     3                 3              1              3      |     14  1.8|
      Artery, Inflammation, Acute          |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  28        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    A  +     +  +  +  +           A  +     +        +     +     +  +      |  26        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    A  +     +  +  +  +           A  +     +        +     +     +  +      |  26        |
      Epithelium, Acanthosis, Diffuse      |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  23        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 107                                                               
NTP Experiment-Test: 05075-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4|            |
                                           | 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Atrium Left, Thrombosis              |                                                                          |      2     |
      Myocardium, Degeneration, Multifocal |    2  2     3  2  2  2           2  1     3        3     3        2      |     27  2.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Nodular                 | 1     1  2  2              1  3     3  1        1  1  1  1     2        2|     19  1.7|
      Hypertrophy, Focal                   |                         1                             1                  |      3  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Nodular                 | 1           2                       2  2     1  1     1           1  2  2|     21  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  25        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    M  +     +  +  +  +           +  +     +        +     +     M  +     +|  27        |
      Pars Distalis, Hyperplasia, Nodular  |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    A  +     +  +  +  A              +     +        +     +     +  +      |  23        |
      C-Cell, Hyperplasia                  |       1     3  3  1                 2                          3  1      |     16  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  30        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |    1           2  1  1           2  3     1        2     2     1         |     21  1.6|
      Inflammation, Chronic Active         |       2     1                                                     2      |      7  2.0|
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Granuloma                            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Interstitial Cell, Hyperplasia       |                                  2                                       |      1  2.0|
      Seminiferous Tubule, Atrophy         |                   2           2              4  4        4  4            |      9  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Femoral, Hyperplasia                 |             2  2  2                 2                    3        3      |     16  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as: