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https://ntp.niehs.nih.gov/go/2439

TDMS Study 05077-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL


NTP Experiment-Test: 05077-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: DOSED FEED                                                                                                 Time: 09:16:34




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  67774327

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            3            5            2            4            8           
    Natural Death                                      4            2           13           10           13           25           
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           45           32           38           33           17           
  Animals Examined Microscopically                    50           50           50           50           50           50           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (50)         (45)         (46)         (38)         (45)         
      Hemorrhage                                                                                                        1 (2%)      
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Epithelium, Inclusion Body Intracytoplasmic                                1 (2%)                    1 (3%)                   
   Intestine Large, Cecum                             (47)         (50)         (49)         (50)         (46)         (50)         
      Parasite Metazoan                                             1 (2%)                    2 (4%)       2 (4%)       5 (10%)     
      Mucosa, Hyperplasia                                                                                  1 (2%)                   
   Intestine Large, Colon                             (48)         (50)         (49)         (49)         (47)         (50)         
      Parasite Metazoan                                2 (4%)       2 (4%)       1 (2%)       2 (4%)       5 (11%)      7 (14%)     
   Intestine Large, Rectum                            (49)         (50)         (48)         (50)         (46)         (50)         
      Parasite Metazoan                                1 (2%)       1 (2%)                    3 (6%)       2 (4%)       4 (8%)      
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Duodenum                          (48)         (50)         (49)         (50)         (50)         (47)         
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)       1 (2%)       1 (2%)                   
      Ulcer                                                                      2 (4%)                    1 (2%)                   
      Peyer's Patch, Infiltration Cellular,                                                                                         
          Histiocyte                                                             1 (2%)                                             
   Intestine Small, Ileum                             (46)         (50)         (46)         (50)         (47)         (45)         
      Hyperplasia                                      1 (2%)                                                                       
      Parasite Metazoan                                                                                                 1 (2%)      
   Intestine Small, Jejunum                           (47)         (50)         (47)         (49)         (47)         (44)         
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic Active                                                                         1 (2%)                   
      Parasite Metazoan                                                                       1 (2%)                                
      Ulcer                                            1 (2%)                    1 (2%)                    1 (2%)                   
   Liver                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Angiectasis                                      1 (2%)                                              1 (2%)       1 (2%)      
      Basophilic Focus                                 1 (2%)                                 2 (4%)       8 (16%)      3 (6%)      
      Clear Cell Focus                                 2 (4%)       5 (10%)                  22 (44%)     13 (26%)      4 (8%)      
      Cytomegaly                                                    6 (12%)     14 (28%)     49 (98%)     49 (98%)     50 (100%)    
      Cytoplasmic Alteration                                        1 (2%)                                                          
      Eosinophilic Focus                               1 (2%)       3 (6%)       2 (4%)      18 (36%)     16 (32%)      4 (8%)      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fatty Change                                                               2 (4%)      39 (78%)     44 (88%)     43 (86%)     
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)       3 (6%)       1 (2%)       1 (2%)      
      Infiltration Cellular, Mixed Cell                1 (2%)                                                                       
      Necrosis, Coagulative                            1 (2%)       2 (4%)       5 (10%)     18 (36%)      9 (18%)     31 (62%)     
      Thrombosis                                                    1 (2%)                    1 (2%)       1 (2%)       7 (14%)     
      Bile Duct, Cyst                                                                                      1 (2%)                   
      Bile Duct, Hyperplasia                                                                  9 (18%)      9 (18%)      6 (12%)     
      Hepatocyte, Necrosis                                                       2 (4%)      23 (46%)     15 (30%)      4 (8%)      
      Sinusoid, Congestion                                                                    1 (2%)                                
   Mesentery                                          (2)          (1)          (4)          (3)          (2)          (1)          
      Hyperplasia, Lymphoid                            1 (50%)                                                                      
      Inflammation, Chronic                                                                   2 (67%)      1 (50%)                  
      Inflammation, Necrotizing                        1 (50%)                   2 (50%)      1 (33%)                               
   Pancreas                                           (48)         (50)         (49)         (50)         (50)         (48)         
      Hemorrhage                                                                                                        1 (2%)      
      Hypoplasia                                       1 (2%)                                 1 (2%)                                
      Necrosis                                                                                2 (4%)                                
      Acinus, Atrophy                                  1 (2%)       3 (6%)       2 (4%)       1 (2%)       2 (4%)                   
      Artery, Inflammation, Chronic                                                           1 (2%)       2 (4%)       6 (13%)     
      Duct, Ectasia                                                 3 (6%)       1 (2%)       4 (8%)                    2 (4%)      
      Interlobular, Inflammation, Chronic                                        1 (2%)       1 (2%)       2 (4%)       1 (2%)      
   Salivary Glands                                    (50)         (49)         (49)         (49)         (48)         (47)         
      Abscess                                          2 (4%)                    1 (2%)       1 (2%)                                
      Bacterium                                        2 (4%)                    1 (2%)                                             
      Mucocele                                                                                1 (2%)                                
   Stomach, Forestomach                               (49)         (50)         (47)         (50)         (50)         (50)         
      Cyst Epithelial Inclusion                                     1 (2%)                                 1 (2%)       1 (2%)      
      Hyperplasia                                                                                          1 (2%)                   
      Inflammation, Chronic                                                                   1 (2%)       1 (2%)                   
      Ulcer                                                                                                2 (4%)                   
   Stomach, Glandular                                 (47)         (49)         (48)         (50)         (49)         (50)         
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic                                                                                1 (2%)                   
      Ulcer                                                                                   1 (2%)                                
      Epithelium, Metaplasia, Squamous                                                                     1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (1)          (1)          (2)                       
      Aorta, Inflammation, Chronic Active                                                     1 (100%)     2 (100%)                 
      Pulmonary Artery, Inflammation, Chronic                                    1 (100%)                                           
   Heart                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Coronary Artery, Inflammation, Chronic           1 (2%)                    1 (2%)                    2 (4%)                   
      Myocardium, Inflammation, Acute, Multifocal                                             2 (4%)                                
      Myocardium, Inflammation, Chronic, Multifocal    1 (2%)                    1 (2%)                                 1 (2%)      
      Myocardium, Mineralization, Multifocal                                                  1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Valve, Bacterium                                 1 (2%)                                                                       
      Valve, Inflammation, Chronic Active                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (50)         (50)         (50)         (50)         
      Subcapsular, Hyperplasia                         4 (8%)       5 (10%)                   1 (2%)                                
   Adrenal Gland, Cortex                              (50)         (49)         (50)         (49)         (50)         (50)         
      Cyst                                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                                           3 (6%)       3 (6%)                                
      Hyperplasia                                      1 (2%)       2 (4%)       3 (6%)                    1 (2%)                   
      Zona Reticularis, Vacuolization Cytoplasmic      1 (2%)       2 (4%)       4 (8%)       1 (2%)       3 (6%)                   
   Adrenal Gland, Medulla                             (50)         (49)         (50)         (49)         (50)         (49)         
      Hyperplasia                                      2 (4%)                    2 (4%)                    2 (4%)       1 (2%)      
   Pituitary Gland                                    (48)         (47)         (49)         (48)         (47)         (44)         
      Angiectasis                                      1 (2%)                                                                       
      Pars Distalis, Angiectasis                                                 1 (2%)                                             
      Pars Distalis, Cyst                                           1 (2%)                                                          
      Pars Distalis, Hyperplasia, Nodular             12 (25%)     16 (34%)      9 (18%)      7 (15%)      8 (17%)      4 (9%)      
   Thyroid Gland                                      (49)         (50)         (50)         (50)         (50)         (50)         
      Inflammation, Chronic                                         2 (4%)       1 (2%)                    1 (2%)                   
      Inflammation, Subacute                                        1 (2%)                                                          
      Follicle, Hyperplasia, Nodular                   2 (4%)       5 (10%)      3 (6%)       6 (12%)     11 (22%)     15 (30%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                               (2)                                    (1)          
      Abscess                                                                    1 (50%)                                            
   Ovary                                              (47)         (49)         (48)         (48)         (49)         (49)         
      Angiectasis                                                                1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic Active                                               3 (6%)       1 (2%)                                
      Mineralization                                                1 (2%)                    1 (2%)                    1 (2%)      
      Thrombosis                                                                 1 (2%)                    1 (2%)                   
      Bilateral, Periovarian Tissue, Cyst                           2 (4%)                                                          
      Follicle, Cyst                                   3 (6%)       3 (6%)       2 (4%)       6 (13%)      4 (8%)       2 (4%)      
      Periovarian Tissue, Cyst                        11 (23%)     12 (24%)      8 (17%)      4 (8%)       9 (18%)      4 (8%)      
      Rete Ovarii, Cyst                                1 (2%)       1 (2%)       3 (6%)                    2 (4%)       2 (4%)      
   Uterus                                             (49)         (50)         (49)         (50)         (49)         (49)         
      Angiectasis                                                                1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Dilatation                                                    6 (12%)                                                         
      Inflammation, Acute                                                        2 (4%)                                             
      Inflammation, Chronic                                                                                1 (2%)                   
      Inflammation, Granulomatous                                                1 (2%)                                             
      Inflammation, Suppurative                                                               1 (2%)                                
      Thrombosis                                                                                           1 (2%)                   
      Endometrium, Hyperplasia, Cystic                46 (94%)     42 (84%)     38 (78%)     32 (64%)     24 (49%)     11 (22%)     
      Endometrium, Endothelium, Metaplasia,                                                                                         
          Squamous                                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)         (50)         
      Calvarium, Myelofibrosis                         6 (12%)     21 (42%)     13 (26%)      5 (10%)                               
      Femoral, Myelofibrosis                          13 (26%)     21 (42%)     13 (26%)      9 (18%)      5 (10%)      1 (2%)      
      Myeloid Cell, Hyperplasia                                     1 (2%)                                                          
      Sternal, Myelofibrosis                          42 (84%)      1 (2%)       1 (2%)      11 (22%)     11 (22%)      2 (4%)      
   Lymph Node                                         (48)         (49)         (48)         (50)         (49)         (47)         
      Lumbar, Hyperplasia, Plasma Cell                                           1 (2%)                                             
      Lumbar, Infiltration Cellular, Histiocyte        1 (2%)                    1 (2%)                                             
      Mandibular, Abscess                                                                     1 (2%)                                
      Mandibular, Bacterium                                                                   1 (2%)                                
      Mandibular, Hyperplasia, Lymphoid                             1 (2%)                    1 (2%)                                
      Mandibular, Infiltration Cellular, Histiocyte    1 (2%)                                                                       
      Mediastinal, Hematopoietic Cell Proliferation                 1 (2%)                                                          
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)                                                                       
      Mediastinal, Hyperplasia, Plasma Cell            1 (2%)                                                                       
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   1 (2%)                                                                       
      Renal, Infiltration Cellular, Histiocyte                                                1 (2%)                                
      Sinus, Mandibular, Ectasia                                    2 (4%)       3 (6%)                    1 (2%)                   
   Lymph Node, Mesenteric                             (8)          (21)         (15)         (21)         (23)         (20)         
      Hematopoietic Cell Proliferation                              2 (10%)      4 (27%)      5 (24%)      8 (35%)      7 (35%)     
      Hyperplasia, Lymphoid                            2 (25%)      3 (14%)                   5 (24%)      3 (13%)      3 (15%)     
      Hyperplasia, Plasma Cell                                                   1 (7%)       2 (10%)                   1 (5%)      
      Infiltration Cellular, Histiocyte                1 (13%)                   1 (7%)       1 (5%)       4 (17%)                  
      Inflammation, Granulomatous                                                                          1 (4%)                   
      Sinus, Ectasia                                   4 (50%)     10 (48%)      7 (47%)      6 (29%)     15 (65%)     13 (65%)     
   Spleen                                             (48)         (50)         (50)         (50)         (50)         (50)         
      Depletion Lymphoid                                                                                   1 (2%)                   
      Granuloma                                                                                            1 (2%)                   
      Hematopoietic Cell Proliferation                 4 (8%)       2 (4%)       9 (18%)      5 (10%)      8 (16%)     23 (46%)     
      Hyperplasia, Lymphoid                           14 (29%)      9 (18%)      2 (4%)       3 (6%)       2 (4%)                   
      Necrosis, Acute                                                            1 (2%)                                             
      Pigmentation                                                  2 (4%)                                                          
   Thymus                                             (43)         (43)         (31)         (38)         (29)         (27)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Amyloid Deposition                                                         1 (3%)                                             
      Atrophy                                                       1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (50)         (49)         (49)         (50)         (50)         
      Acanthosis                                      31 (63%)     37 (74%)     28 (57%)     44 (90%)     44 (88%)     43 (86%)     
      Hyperkeratosis                                  23 (47%)     29 (58%)     28 (57%)     46 (94%)     42 (84%)     46 (92%)     
      Infiltration Cellular, Mast Cell                                                                                  1 (2%)      
      Inflammation, Necrotizing                                     2 (4%)       1 (2%)       1 (2%)       1 (2%)                   
      Parasite Metazoan                               24 (49%)     28 (56%)     26 (53%)     43 (88%)     38 (76%)     41 (82%)     
      Subcutaneous Tissue, Granuloma                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)         (50)         (50)         
      Tarsal, Hyperostosis                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Cyst Epithelial Inclusion                        1 (2%)       1 (2%)                                                          
      Infarct                                          1 (2%)                                                                       
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Artery, Necrosis, Fibrinoid                                                1 (2%)                                             
      Cerebrum, Compression                                                                   2 (4%)                                
      Hypothalamus, Compression                        1 (2%)       1 (2%)       1 (2%)       2 (4%)       3 (6%)                   
   Peripheral Nerve                                   (1)                                                                           
      Sciatic, Degeneration                            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)         (50)         
      Hemorrhage                                                                              1 (2%)                                
      Alveolar Epithelium, Hyperplasia                                                                                  1 (2%)      
      Alveolus, Infiltration Cellular, Histiocyte                                                          1 (2%)       1 (2%)      
      Alveolus, Inflammation, Acute                                                           1 (2%)                                
      Artery, Thrombosis                                                                                   1 (2%)       2 (4%)      
      Bronchus, Granuloma                                                        1 (2%)                                             
      Interstitium, Inflammation, Chronic              1 (2%)                                 1 (2%)       1 (2%)                   
      Lymphatic, Infiltration Cellular,                                                                                             
          Polymorphonuclear                                                                                             1 (2%)      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Vein, Thrombosis                                                                                                  1 (2%)      
   Nose                                               (50)         (50)         (50)         (50)         (49)         (50)         
      Nerve, Inflammation, Chronic Active                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                                    (1)                       
      Middle Ear, Abscess                                                                                  1 (100%)                 
      Middle Ear, Bacterium                                                                                1 (100%)                 
   Harderian Gland                                    (6)          (1)          (6)          (2)          (2)          (1)          
      Atrophy                                                                    1 (17%)                                            
      Hyperplasia, Nodular                             2 (33%)                   1 (17%)                                1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (50)         (50)         
      Cyst                                                                       1 (2%)                                             
      Infarct                                                       1 (2%)       1 (2%)                                             
      Infiltration Cellular, Lymphocyte                2 (4%)                                                                       
      Infiltration Cellular, Mixed Cell                1 (2%)                                                                       
      Inflammation, Chronic                                                                                1 (2%)                   
      Metaplasia, Osseous                                                        2 (4%)       1 (2%)                    1 (2%)      
      Mineralization                                                                          2 (4%)                                
      Nephropathy, Chronic                                                       3 (6%)       3 (6%)       6 (12%)      5 (10%)     
      Glomerulus, Inflammation,                                                                                                     
          Membranoproliferative                                                                                         2 (4%)      
      Renal Tubule, Casts Protein                                                                                       1 (2%)      
   Urinary Bladder                                    (48)         (50)         (49)         (48)         (49)         (49)         
      Inflammation, Acute                                                                                  1 (2%)                   
      Inflammation, Chronic Active                                                            1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Natural Death                                     34           35                                                               
    Moribund Sacrifice                                16           15                                                               
  Survivors                                                                                                                         
  Animals Examined Microscopically                    49           49                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (45)         (45)                                                             
      Parasite Metazoan                                2 (4%)       5 (11%)                                                         
   Intestine Large, Colon                             (44)         (45)                                                             
      Parasite Metazoan                               22 (50%)     17 (38%)                                                         
   Intestine Large, Rectum                            (45)         (46)                                                             
      Parasite Metazoan                                2 (4%)       2 (4%)                                                          
   Intestine Small, Ileum                             (39)         (41)                                                             
      Parasite Metazoan                                2 (5%)       2 (5%)                                                          
   Liver                                              (48)         (47)                                                             
      Clear Cell Focus                                 1 (2%)       3 (6%)                                                          
      Cyst                                             2 (4%)                                                                       
      Cytomegaly                                      48 (100%)    47 (100%)                                                        
      Eosinophilic Focus                               4 (8%)       8 (17%)                                                         
      Fatty Change                                    46 (96%)     47 (100%)                                                        
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)                                                          
      Necrosis, Coagulative                           34 (71%)     20 (43%)                                                         
      Thrombosis                                       6 (13%)      6 (13%)                                                         
      Bile Duct, Cyst                                  1 (2%)                                                                       
      Bile Duct, Hyperplasia                          40 (83%)     37 (79%)                                                         
      Hepatocyte, Necrosis                            10 (21%)      3 (6%)                                                          
   Mesentery                                          (1)                                                                           
      Inflammation, Chronic                            1 (100%)                                                                     
   Pancreas                                           (41)         (47)                                                             
      Hemorrhage                                                    1 (2%)                                                          
      Infarct                                          1 (2%)                                                                       
      Artery, Inflammation, Chronic                    8 (20%)      4 (9%)                                                          
      Interlobular, Inflammation, Chronic                           1 (2%)                                                          
   Stomach, Forestomach                               (45)         (46)                                                             
      Acanthosis                                                    1 (2%)                                                          
      Hyperkeratosis                                   1 (2%)       1 (2%)                                                          
   Stomach, Glandular                                 (44)         (45)                                                             
      Ulcer                                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Aorta, Inflammation, Chronic Active              1 (100%)                                                                     
   Heart                                              (45)         (45)                                                             
      Atrium, Dilatation                               1 (2%)                                                                       
      Coronary Artery, Inflammation, Chronic           1 (2%)                                                                       
      Myocardium, Inflammation, Chronic, Multifocal    2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (44)         (47)                                                             
      Subcapsular, Hyperplasia                         3 (7%)       4 (9%)                                                          
   Adrenal Gland, Cortex                              (43)         (47)                                                             
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)                                                          
      Infarct                                          1 (2%)                                                                       
   Thyroid Gland                                      (43)         (44)                                                             
      Follicle, Hyperplasia, Nodular                   4 (9%)       9 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (45)         (46)                                                             
      Mineralization                                   1 (2%)                                                                       
      Follicle, Cyst                                   1 (2%)                                                                       
      Periovarian Tissue, Cyst                         1 (2%)       1 (2%)                                                          
      Rete Ovarii, Cyst                                2 (4%)                                                                       
   Uterus                                             (48)         (48)                                                             
      Pigmentation                                     1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                 2 (4%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)                                                             
      Myeloid Cell, Hyperplasia                                     1 (2%)                                                          
   Lymph Node                                         (42)         (41)                                                             
      Mandibular, Hematopoietic Cell Proliferation                  1 (2%)                                                          
      Mandibular, Hyperplasia, Lymphoid                1 (2%)       1 (2%)                                                          
      Pancreatic, Sinus, Ectasia                       1 (2%)                                                                       
      Sinus, Mandibular, Ectasia                       1 (2%)       1 (2%)                                                          
   Lymph Node, Mesenteric                             (7)          (10)                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                 2 (29%)      8 (80%)                                                         
      Infiltration Cellular, Histiocyte                1 (14%)                                                                      
      Sinus, Ectasia                                   5 (71%)      2 (20%)                                                         
   Spleen                                             (44)         (47)                                                             
      Hematopoietic Cell Proliferation                37 (84%)     29 (62%)                                                         
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Pigmentation                                     1 (2%)                                                                       
   Thymus                                             (20)         (32)                                                             
      Ectopic Parathyroid Gland                        1 (5%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (47)                                                             
      Acanthosis                                      38 (78%)     30 (64%)                                                         
      Hyperkeratosis                                  39 (80%)     33 (70%)                                                         
      Parasite Metazoan                               33 (67%)     31 (66%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (46)         (44)                                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)                                                                       
      Interstitium, Inflammation, Chronic              1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                                                                           
      Hyperplasia, Nodular                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (46)         (49)                                                             
      Metaplasia, Osseous                              1 (2%)                                                                       
      Nephropathy, Chronic                            16 (35%)     29 (59%)                                                         
      Glomerulus, Inflammation,                                                                                                     
          Membranoproliferative                        1 (2%)                                                                       
      Glomerulus, Nephropathy, Chronic                 2 (4%)                                                                       
   Urinary Bladder                                    (45)         (47)                                                             
      Parasite Metazoan                                1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           49           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9            5            2            5            2            3           
    Natural Death                                     10           13            5           11           14           18           
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           32           41           34           33           27           
    Natural Death                                                                1                         1            2           
  Animals Examined Microscopically                    50           50           49           50           50           50           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (38)         (43)         (45)         (43)         (39)         (36)         
      Epithelium, Hyperplasia                          1 (3%)       1 (2%)                                                          
      Epithelium, Inclusion Body Intracytoplasmic                   2 (5%)       1 (2%)                                             
      Lumen, Crystals                                               1 (2%)                                                          
   Intestine Large, Cecum                             (47)         (49)         (44)         (49)         (49)         (48)         
      Parasite Metazoan                                             1 (2%)       1 (2%)       1 (2%)                    1 (2%)      
      Ulcer                                            1 (2%)                                 2 (4%)                                
   Intestine Large, Colon                             (47)         (49)         (46)         (49)         (50)         (49)         
      Parasite Metazoan                                1 (2%)       2 (4%)       2 (4%)       4 (8%)       9 (18%)     14 (29%)     
   Intestine Large, Rectum                            (50)         (49)         (44)         (48)         (48)         (47)         
      Parasite Metazoan                                3 (6%)       4 (8%)       1 (2%)       4 (8%)       5 (10%)      2 (4%)      
   Intestine Small, Duodenum                          (49)         (49)         (45)         (49)         (49)         (47)         
      Inflammation, Chronic Active                                                                         1 (2%)                   
   Intestine Small, Ileum                             (47)         (47)         (45)         (46)         (49)         (43)         
      Parasite Metazoan                                             2 (4%)                    2 (4%)                    2 (5%)      
      Ulcer                                            1 (2%)                                 2 (4%)                                
   Intestine Small, Jejunum                           (48)         (45)         (47)         (46)         (48)         (47)         
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Parasite Metazoan                                                                                    1 (2%)                   
      Ulcer                                                         1 (2%)       1 (2%)       1 (2%)       1 (2%)       1 (2%)      
   Liver                                              (50)         (50)         (48)         (49)         (49)         (50)         
      Abscess                                                                    1 (2%)                                             
      Amyloid Deposition                                            1 (2%)                                                          
      Bacterium                                                                  1 (2%)                                             
      Basophilic Focus                                 2 (4%)       6 (12%)      1 (2%)       3 (6%)       7 (14%)      8 (16%)     
      Clear Cell Focus                                             13 (26%)     15 (31%)      8 (16%)      8 (16%)      5 (10%)     
      Cyst                                             1 (2%)       1 (2%)                    1 (2%)                                
      Cytologic Alterations                                        21 (42%)                                                         
      Cytomegaly                                                   36 (72%)     44 (92%)     49 (100%)    48 (98%)     48 (96%)     
      Eosinophilic Focus                               3 (6%)      20 (40%)      8 (17%)     16 (33%)      4 (8%)                   
      Fatty Change                                     2 (4%)       2 (4%)       4 (8%)      45 (92%)     43 (88%)     40 (80%)     
      Granuloma                                        1 (2%)                                                           1 (2%)      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)                                                          
      Necrosis, Coagulative                            1 (2%)       9 (18%)      5 (10%)     17 (35%)     16 (33%)     23 (46%)     
      Parasite Metazoan                                                                                                 1 (2%)      
      Thrombosis                                                    6 (12%)      1 (2%)       3 (6%)       1 (2%)       6 (12%)     
      Bile Duct, Dilatation                                                      1 (2%)                                             
      Bile Duct, Hyperplasia                                                                                            8 (16%)     
      Hepatocyte, Necrosis                                          3 (6%)       3 (6%)       4 (8%)       1 (2%)       4 (8%)      
      Oval Cell, Hyperplasia                                                                               2 (4%)                   
      Oval Cell, Proliferation                                                                                          1 (2%)      
   Mesentery                                          (5)          (3)                                                 (2)          
      Inflammation, Acute                              1 (20%)                                                                      
      Inflammation, Chronic                            1 (20%)      1 (33%)                                             2 (100%)    
      Inflammation, Necrotizing                        2 (40%)                                                                      
   Pancreas                                           (50)         (50)         (47)         (49)         (49)         (48)         
      Necrosis                                         1 (2%)                                                                       
      Acinus, Atrophy                                                                                      1 (2%)       2 (4%)      
      Artery, Inflammation, Chronic                    1 (2%)                                 2 (4%)                    2 (4%)      
      Duct, Ectasia                                                                                        1 (2%)       1 (2%)      
      Interlobular, Inflammation, Chronic              1 (2%)       1 (2%)                                                          
   Salivary Glands                                    (50)         (49)         (49)         (49)         (50)         (49)         
      Abscess                                                                                              1 (2%)                   
      Bacterium                                                                                            1 (2%)                   
      Duct, Fibrosis                                                             1 (2%)                                             
   Stomach, Forestomach                               (48)         (49)         (47)         (50)         (49)         (47)         
      Acanthosis                                       2 (4%)       1 (2%)                                                          
      Cyst Epithelial Inclusion                                                                                         1 (2%)      
      Hyperkeratosis                                   2 (4%)       1 (2%)                                                          
      Inflammation, Chronic                                                                                             1 (2%)      
      Inflammation, Necrotizing                        1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
   Stomach, Glandular                                 (48)         (48)         (47)         (50)         (49)         (47)         
      Ectopic Tissue                                   1 (2%)                                                                       
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                              1 (2%)                   
      Ulcer                                                                                                1 (2%)                   
      Mucosa, Hyperplasia                                                        1 (2%)                                             
      Mucosa, Mineralization                                                                                            1 (2%)      
   Tooth                                                           (4)          (4)          (3)          (6)          (1)          
      Gingiva, Inflammation, Chronic Active                         2 (50%)      2 (50%)                   1 (17%)                  
      Pulp, Inflammation, Chronic Active                            2 (50%)      2 (50%)      2 (67%)      4 (67%)      1 (100%)    
      Pulp, Inflammation, Suppurative                                                         1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (49)         (50)         (50)         (50)         
      Ectopic Tissue                                                                                                    1 (2%)      
      Coronary Artery, Inflammation, Chronic           2 (4%)       1 (2%)                    1 (2%)       1 (2%)                   
      Epicardium, Inflammation, Chronic                2 (4%)                                                                       
      Myocardium, Inflammation, Chronic, Multifocal    1 (2%)       2 (4%)       1 (2%)       2 (4%)       3 (6%)       2 (4%)      
      Myocardium, Mineralization, Multifocal                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (39)         (50)         (48)         (49)         (50)         (50)         
      Subcapsular, Hyperplasia                         4 (10%)      3 (6%)                    1 (2%)       1 (2%)                   
   Adrenal Gland, Cortex                              (39)         (50)         (47)         (49)         (50)         (50)         
      Amyloid Deposition                                            1 (2%)                                                          
      Hyperplasia                                      1 (3%)       3 (6%)                                 1 (2%)       2 (4%)      
      Hypertrophy                                                   1 (2%)                                                          
      Infarct                                          1 (3%)                                                                       
      Zona Glomerulosa, Cytoplasmic Alteration         1 (3%)                                                                       
   Adrenal Gland, Medulla                             (38)         (50)         (47)         (49)         (49)         (50)         
      Hyperplasia                                      2 (5%)       2 (4%)       2 (4%)                                 1 (2%)      
   Islets, Pancreatic                                 (48)         (49)         (46)         (48)         (48)         (45)         
      Hyperplasia                                                   1 (2%)       1 (2%)                    1 (2%)                   
   Pituitary Gland                                    (44)         (44)         (45)         (46)         (44)         (41)         
      Pars Distalis, Hyperplasia, Nodular                                                                  2 (5%)                   
   Thyroid Gland                                      (50)         (49)         (47)         (49)         (48)         (48)         
      Inflammation, Chronic                            1 (2%)                                                                       
      Follicle, Hyperplasia, Nodular                                                                       3 (6%)      16 (33%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (48)         (50)         (49)         (50)         
      Granuloma Sperm                                               1 (2%)                                 1 (2%)                   
      Inflammation, Chronic                                                                                             2 (4%)      
      Inflammation, Chronic Active                                                                         1 (2%)                   
   Preputial Gland                                    (3)          (1)                       (1)          (2)                       
      Abscess                                          2 (67%)                                1 (100%)     2 (100%)                 
      Duct, Dilatation                                 1 (33%)      1 (100%)                                                        
   Prostate                                           (50)         (50)         (48)         (49)         (49)         (49)         
      Inflammation, Chronic Active                                  1 (2%)                                 1 (2%)       1 (2%)      
      Inflammation, Suppurative                                                               1 (2%)       3 (6%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Serosa, Inflammation, Necrotizing                1 (2%)                                                                       
   Testes                                             (50)         (50)         (49)         (50)         (49)         (50)         
      Seminiferous Tubule, Atrophy                                  1 (2%)       1 (2%)                                 1 (2%)      
      Seminiferous Tubule, Hypospermia                                                                                  1 (2%)      
      Tunic, Inflammation, Necrotizing                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (49)         (50)         (49)         
      Myeloid Cell, Hyperplasia                                     1 (2%)                                                          
   Lymph Node                                         (48)         (50)         (48)         (48)         (48)         (46)         
      Deep Cervical, Hyperplasia, Plasma Cell                       1 (2%)                                                          
      Deep Cervical, Sinus, Ectasia                    1 (2%)                                                                       
      Lumbar, Hyperplasia, Plasma Cell                                                                     1 (2%)                   
      Mandibular, Abscess                              1 (2%)       1 (2%)                    1 (2%)                                
      Mandibular, Bacterium                            1 (2%)                                 1 (2%)                                
      Mandibular, Hyperplasia, Lymphoid                             2 (4%)       1 (2%)       1 (2%)                                
      Mandibular, Hyperplasia, Plasma Cell                                                    1 (2%)       1 (2%)                   
      Mandibular, Infiltration Cellular, Histiocyte                 1 (2%)                    1 (2%)                                
      Mediastinal, Hematopoietic Cell Proliferation    1 (2%)                                                                       
      Mediastinal, Hyperplasia, Plasma Cell            1 (2%)                                                                       
      Mediastinal, Sinus, Ectasia                                                                                       1 (2%)      
      Pancreatic, Hematopoietic Cell Proliferation                                                         1 (2%)                   
      Pancreatic, Hyperplasia, Lymphoid                                                       1 (2%)                                
      Renal, Hyperplasia, Lymphoid                                                            1 (2%)                                
      Sinus, Mandibular, Ectasia                       1 (2%)                                                           1 (2%)      
   Lymph Node, Mesenteric                             (32)         (34)         (34)         (37)         (35)         (31)         
      Angiectasis                                                   1 (3%)                                                          
      Hematopoietic Cell Proliferation                13 (41%)     12 (35%)     14 (41%)     20 (54%)     13 (37%)     14 (45%)     
      Hyperplasia, Lymphoid                            1 (3%)                    8 (24%)      8 (22%)      5 (14%)      2 (6%)      
      Hyperplasia, Plasma Cell                         1 (3%)                                                           1 (3%)      
      Infiltration Cellular, Histiocyte                             4 (12%)      6 (18%)      8 (22%)      9 (26%)      2 (6%)      
      Inflammation, Granulomatous                      1 (3%)       1 (3%)                                                          
      Artery, Thrombosis                                                         1 (3%)                                             
      Sinus, Ectasia                                   9 (28%)     18 (53%)     16 (47%)     14 (38%)     19 (54%)     24 (77%)     
   Spleen                                             (50)         (50)         (47)         (49)         (50)         (48)         
      Amyloid Deposition                                            1 (2%)                    1 (2%)                                
      Depletion Lymphoid                               1 (2%)                                 2 (4%)                                
      Fibrosis                                                                                                          1 (2%)      
      Hematopoietic Cell Proliferation                10 (20%)      9 (18%)      1 (2%)       8 (16%)      8 (16%)     11 (23%)     
      Hyperplasia, Lymphoid                            3 (6%)       2 (4%)       7 (15%)      5 (10%)      2 (4%)                   
      Infiltration Cellular, Plasma Cell               1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                                                (2)                                    (1)          
      Duct, Ectasia                                                              1 (50%)                                            
   Skin                                               (50)         (50)         (49)         (49)         (50)         (49)         
      Abscess                                                       1 (2%)                                                          
      Acanthosis                                      29 (58%)     35 (70%)     32 (65%)     38 (78%)     38 (76%)     31 (63%)     
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Hyperkeratosis                                  24 (48%)     35 (70%)     29 (59%)     37 (76%)     38 (76%)     33 (67%)     
      Inflammation, Chronic                                         1 (2%)                                              1 (2%)      
      Inflammation, Necrotizing                                     2 (4%)                                                          
      Parasite Metazoan                               23 (46%)     35 (70%)     29 (59%)     36 (73%)     36 (72%)     29 (59%)     
      Ulcer                                                         1 (2%)                                                          
      Dermis, Metaplasia, Osseous                                   1 (2%)                                                          
      Sebaceous Gland, Ectasia                                                                1 (2%)                                
      Subcutaneous Tissue, Fat, Necrosis               2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (49)         (50)         (50)         (50)         
      Coccygeal, Fracture Healed                                                 1 (2%)                                             
      Femur, Osteopetrosis                                                       1 (2%)                                             
      Tarsal, Hyperostosis                             5 (10%)      5 (10%)     10 (20%)                   1 (2%)       2 (4%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)         (50)         (49)         
      Bacterium                                                                  1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Hypothalamus, Compression                                                                                         1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)         (50)         (50)         
      Abscess                                                       1 (2%)                                                          
      Bacterium                                                     1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 3 (6%)                    1 (2%)       1 (2%)       2 (4%)       2 (4%)      
      Alveolus, Infiltration Cellular, Histiocyte      2 (4%)       2 (4%)       2 (4%)       1 (2%)       1 (2%)       1 (2%)      
      Alveolus, Inflammation, Acute                                                                                     2 (4%)      
      Artery, Thrombosis                               1 (2%)                                 1 (2%)       1 (2%)       1 (2%)      
      Bronchus, Foreign Body                           1 (2%)                                                                       
      Interstitium, Inflammation, Chronic              2 (4%)       1 (2%)                    2 (4%)       1 (2%)                   
      Mediastinum, Inflammation, Chronic Active        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (1)                                                 
      Synechia                                                                   1 (100%)                                           
      Anterior Chamber, Inflammation, Suppurative                   1 (100%)                                                        
   Harderian Gland                                    (3)          (4)          (5)          (1)          (1)          (3)          
      Hyperplasia, Nodular                                                                    1 (100%)                              
      Inflammation, Necrotizing                        1 (33%)                                                                      
      Duct, Dilatation                                                                        1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)         (49)         (48)         
      Abscess                                                       1 (2%)                                                          
      Bacterium                                                                               1 (2%)                                
      Cyst                                                          6 (12%)      3 (6%)       1 (2%)       4 (8%)                   
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                          1 (2%)       1 (2%)                                 1 (2%)       1 (2%)      
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation, Acute                                                                     1 (2%)                                
      Metaplasia, Osseous                                                                                  2 (4%)       3 (6%)      
      Nephropathy, Chronic                             9 (18%)      8 (16%)      8 (16%)     10 (20%)     11 (22%)      5 (10%)     
      Artery, Inflammation, Subacute                   1 (2%)                                                                       
      Glomerulus, Amyloid Deposition                                1 (2%)                                                          
      Glomerulus, Inflammation,                                                                                                     
          Membranoproliferative                                                                            1 (2%)       2 (4%)      
      Glomerulus, Nephropathy, Chronic                                                                     1 (2%)                   
   Urinary Bladder                                    (49)         (50)         (48)         (48)         (48)         (50)         
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       1 (2%)                                 1 (2%)      
      Parasite Metazoan                                1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Natural Death                                     34           29                                                               
    Moribund Sacrifice                                16           21                                                               
  Survivors                                                                                                                         
  Animals Examined Microscopically                    50           50                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (41)         (32)                                                             
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Intestine Large, Cecum                             (43)         (49)                                                             
      Cyst                                             1 (2%)                                                                       
      Parasite Metazoan                                2 (5%)       1 (2%)                                                          
   Intestine Large, Colon                             (50)         (49)                                                             
      Parasite Metazoan                               23 (46%)     20 (41%)                                                         
      Ulcer                                                         1 (2%)                                                          
   Intestine Large, Rectum                            (47)         (49)                                                             
      Parasite Metazoan                                3 (6%)       3 (6%)                                                          
   Intestine Small, Duodenum                          (50)         (47)                                                             
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Metaplasia, Squamous                              1 (2%)                                                          
   Intestine Small, Ileum                             (39)         (40)                                                             
      Parasite Metazoan                                3 (8%)       1 (3%)                                                          
   Intestine Small, Jejunum                           (43)         (47)                                                             
      Parasite Metazoan                                1 (2%)                                                                       
   Liver                                              (50)         (50)                                                             
      Basophilic Focus                                 1 (2%)       7 (14%)                                                         
      Clear Cell Focus                                 1 (2%)       2 (4%)                                                          
      Cytomegaly                                      50 (100%)    50 (100%)                                                        
      Eosinophilic Focus                               6 (12%)      4 (8%)                                                          
      Fatty Change                                    50 (100%)    48 (96%)                                                         
      Hematopoietic Cell Proliferation                 2 (4%)       3 (6%)                                                          
      Infiltration Cellular, Mononuclear Cell                       1 (2%)                                                          
      Infiltration Cellular, Mixed Cell                             1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Necrosis, Coagulative                           24 (48%)     29 (58%)                                                         
      Thrombosis                                       8 (16%)      7 (14%)                                                         
      Bile Duct, Hyperplasia                          34 (68%)     26 (52%)                                                         
      Hepatocyte, Necrosis                             2 (4%)       3 (6%)                                                          
      Vein, Inflammation, Subacute                     1 (2%)                                                                       
   Pancreas                                           (49)         (49)                                                             
      Hemorrhage                                       1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infarct                                          3 (6%)       1 (2%)                                                          
      Acinus, Atrophy                                               1 (2%)                                                          
      Artery, Inflammation, Chronic                    8 (16%)      1 (2%)                                                          
      Duct, Ectasia                                    1 (2%)                                                                       
   Salivary Glands                                    (46)         (47)                                                             
      Abscess                                          1 (2%)                                                                       
      Bacterium                                        1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)                                                             
      Acanthosis                                                    2 (4%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hyperkeratosis                                                2 (4%)                                                          
   Stomach, Glandular                                 (50)         (50)                                                             
      Hemorrhage                                       1 (2%)                                                                       
      Mucosa, Hyperplasia                              2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (3)          (2)                                                              
      Aorta, Inflammation, Chronic Active              2 (67%)      2 (100%)                                                        
      Aorta, Thrombosis                                1 (33%)                                                                      
   Heart                                              (50)         (46)                                                             
      Necrosis                                         1 (2%)                                                                       
      Coronary Artery, Inflammation, Chronic           1 (2%)                                                                       
      Myocardium, Inflammation, Chronic, Multifocal    3 (6%)                                                                       
      Valve, Inflammation, Chronic Active              1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (46)                                                             
      Subcapsular, Hyperplasia                         1 (2%)                                                                       
   Adrenal Gland, Cortex                              (48)         (46)                                                             
      Hyperplasia                                                   1 (2%)                                                          
      Infarct                                          1 (2%)       1 (2%)                                                          
   Adrenal Gland, Medulla                             (49)         (46)                                                             
      Hyperplasia                                      3 (6%)                                                                       
      Infarct                                                       1 (2%)                                                          
   Thyroid Gland                                      (46)         (45)                                                             
      Follicle, Hyperplasia                            1 (2%)                                                                       
      Follicle, Hyperplasia, Nodular                   8 (17%)      9 (20%)                                                         
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)                                                             
      Granuloma Sperm                                  1 (2%)                                                                       
   Preputial Gland                                                 (1)                                                              
      Duct, Dilatation                                              1 (100%)                                                        
   Prostate                                           (50)         (47)                                                             
      Inflammation, Suppurative                        2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)                                                             
      Femoral, Myelofibrosis                                        2 (4%)                                                          
      Myeloid Cell, Hyperplasia                        3 (6%)       1 (2%)                                                          
   Lymph Node                                         (44)         (42)                                                             
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Mandibular, Abscess                              1 (2%)                                                                       
      Mandibular, Fibrosis                             1 (2%)                                                                       
      Mandibular, Hyperplasia, Lymphoid                1 (2%)                                                                       
      Mandibular, Infiltration Cellular, Histiocyte    1 (2%)                                                                       
      Pancreatic, Hematopoietic Cell Proliferation                  1 (2%)                                                          
      Sinus, Mandibular, Ectasia                                    1 (2%)                                                          
   Lymph Node, Mesenteric                             (11)         (10)                                                             
      Hematopoietic Cell Proliferation                 3 (27%)      4 (40%)                                                         
      Sinus, Ectasia                                   7 (64%)      6 (60%)                                                         
   Spleen                                             (49)         (48)                                                             
      Hematopoietic Cell Proliferation                41 (84%)     32 (67%)                                                         
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (49)                                                             
      Acanthosis                                      26 (52%)     31 (63%)                                                         
      Erosion                                                       1 (2%)                                                          
      Hyperkeratosis                                  29 (58%)     34 (69%)                                                         
      Parasite Metazoan                               18 (36%)     21 (43%)                                                         
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
NTP Experiment-Test: 05077-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:34  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (46)                                                             
      Alveolus, Infiltration Cellular, Histiocyte                   1 (2%)                                                          
      Alveolus, Inflammation, Acute                    1 (2%)                                                                       
      Bronchus, Metaplasia, Squamous                   1 (2%)                                                                       
      Mediastinum, Inflammation, Chronic Active        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)                                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Nephropathy, Chronic                            44 (88%)     29 (59%)                                                         
      Artery, Inflammation, Subacute                                2 (4%)                                                          
      Fat, Necrosis                                    1 (2%)                                                                       
      Glomerulus, Infiltration Cellular,                                                                                            
          Mononuclear Cell                                          1 (2%)                                                          
      Glomerulus, Inflammation,                                                                                                     
          Membranoproliferative                        1 (2%)       1 (2%)                                                          
   Urinary Bladder                                    (47)         (47)                                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mucosa, Hyperplasia                              1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   21                                                              
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                             ----------              END OF REPORT             ----------                                           
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