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TDMS Study 05079-02 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                                TALC


NTP Experiment-Test: 05079-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:51




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  14807966

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05079-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTOL       CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           39           50           40           50           40           
  Scheduled Sacrifice                                              30                        30                        29           
  Early Deaths                                                                                                                      
    Natural Death                                     17            7           21            5           21           10           
    Moribund Sacrifice                                 2            2            4            5            4            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                30                        23                        25                        
  Missing                                              1                         1                                                  
  Culled                                                                         1                                                  
  Animals Examined Microscopically                    46           11           49           12           50           12           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (35)         (11)         (30)         (12)         (34)         (12)         
      Hyperplasia, Lymphoid                                                                                1 (3%)                   
      Serosa, Inflammation, Suppurative                                          1 (3%)                                             
   Intestine Large, Colon                             (38)         (11)         (34)         (12)         (32)         (12)         
      Serosa, Inflammation, Suppurative                                          2 (6%)                                             
   Intestine Small, Duodenum                          (27)         (11)         (26)         (12)         (27)         (12)         
      Ulcer, Focal                                     1 (4%)                                                                       
      Mucosa, Atrophy                                  2 (7%)                    6 (23%)                   4 (15%)                  
      Serosa, Inflammation, Suppurative                                          2 (8%)                                             
   Intestine Small, Ileum                             (33)         (11)         (28)         (12)         (31)         (12)         
      Hyperplasia, Lymphoid                            1 (3%)                    1 (4%)                                             
      Mucosa, Atrophy                                  4 (12%)                   6 (21%)                   6 (19%)                  
      Peyer's Patch, Necrosis                                                                              1 (3%)                   
      Serosa, Inflammation, Suppurative                                          2 (7%)                    1 (3%)                   
   Intestine Small, Jejunum                           (33)         (11)         (29)         (12)         (31)         (12)         
      Mucosa, Atrophy                                  2 (6%)                    7 (24%)                   3 (10%)                  
      Serosa, Inflammation, Suppurative                                          2 (7%)                    1 (3%)                   
   Liver                                              (46)         (11)         (47)         (12)         (50)         (12)         
      Clear Cell Focus                                              1 (9%)                                                          
      Eosinophilic Focus                                                         1 (2%)                                             
      Fibrosis, Focal                                                            1 (2%)                                             
      Focal Cellular Change                            2 (4%)                    3 (6%)                    1 (2%)                   
      Hematopoietic Cell Proliferation                 1 (2%)                    2 (4%)                    2 (4%)       1 (8%)      
      Inflammation, Focal                              1 (2%)       1 (9%)       2 (4%)       1 (8%)       1 (2%)                   
      Necrosis, Focal                                  1 (2%)                    2 (4%)                    2 (4%)                   
      Pigmentation, Focal, Hemosiderin                                           1 (2%)                                             
      Centrilobular, Degeneration                                                1 (2%)                                             
      Centrilobular, Necrosis, Coagulative                                       1 (2%)                                             
      Serosa, Inflammation, Suppurative                4 (9%)                    7 (15%)                   5 (10%)                  
      Sinusoid, Inflammation                           2 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05079-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTOL       CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (42)         (11)         (40)         (11)         (44)         (12)         
      Inflammation, Focal                                                                                  2 (5%)                   
      Acinus, Hyperplasia, Focal                       1 (2%)                                                                       
      Serosa, Inflammation, Suppurative                1 (2%)                    5 (13%)                   4 (9%)                   
   Salivary Glands                                    (46)         (11)         (49)         (12)         (50)         (12)         
      Inflammation, Acute                                                        1 (2%)                    1 (2%)                   
      Inflammation, Chronic                                         1 (9%)                    2 (17%)                               
      Duct, Hyperplasia                                             1 (9%)                                                          
   Stomach                                            (45)         (11)         (46)         (12)         (50)         (12)         
      Serosa, Inflammation, Granulomatous                                                                  1 (2%)                   
      Serosa, Inflammation, Suppurative                1 (2%)                    2 (4%)                    1 (2%)                   
   Stomach, Forestomach                               (45)         (11)         (46)         (12)         (50)         (12)         
      Hyperplasia, Focal, Mast Cell                                                                        1 (2%)                   
      Hyperplasia, Focal, Squamous                     2 (4%)                    4 (9%)       1 (8%)       2 (4%)                   
      Ulcer, Focal                                     1 (2%)                    3 (7%)                                             
      Glandular, Inflammation, Focal                                             1 (2%)                    2 (4%)                   
   Stomach, Glandular                                 (45)         (10)         (40)         (12)         (46)         (12)         
      Inflammation, Suppurative                                                                            1 (2%)                   
      Ulcer, Focal                                     1 (2%)                    1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (46)         (11)         (49)         (11)         (50)         (12)         
      Myocardium, Degeneration, Focal                  1 (2%)                                                                       
      Myocardium, Inflammation, Focal                                            1 (2%)                                             
      Myocardium, Mineralization, Focal                1 (2%)                                                                       
      Pericardium, Inflammation, Suppurative           1 (2%)                    2 (4%)                    4 (8%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (46)         (11)         (46)         (12)         (50)         (12)         
      Capsule, Inflammation, Suppurative               4 (9%)                    7 (15%)                   5 (10%)                  
      Corticomedullary Junction, Hemorrhage            2 (4%)                    3 (7%)                    1 (2%)                   
      Spindle Cell, Hyperplasia                       46 (100%)     4 (36%)     46 (100%)     4 (33%)     47 (94%)      4 (33%)     
   Adrenal Gland, Cortex                              (46)         (11)         (45)         (11)         (50)         (12)         
      Cyst                                             2 (4%)                    3 (7%)                                             
      Inflammation, Focal, Suppurative                                                                     1 (2%)                   
      Vacuolization Cytoplasmic, Focal                 3 (7%)                                                                       
   Adrenal Gland, Medulla                             (41)         (10)         (44)         (10)         (45)         (11)         
      Hyperplasia, Focal                               2 (5%)                                                                       
   Parathyroid Gland                                  (23)         (5)          (19)         (3)          (25)         (8)          
      Hyperplasia                                      1 (4%)                                                                       
   Pituitary Gland                                    (42)         (10)         (43)         (8)          (48)         (12)         
      Cyst                                             2 (5%)                                                                       
      Hemorrhage, Focal                                2 (5%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05079-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTOL       CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia, Focal                               2 (5%)                                                                       
      Pigmentation, Lipofuscin                         1 (2%)                                                                       
   Thyroid Gland                                      (43)         (9)          (48)         (9)          (49)         (11)         
      Cyst                                             2 (5%)                                                                       
      Inflammation, Acute, Focal                                                                           2 (4%)                   
      C-Cell, Hyperplasia                              1 (2%)                                              1 (2%)                   
      Follicular Cell, Hyperplasia                     9 (21%)                  12 (25%)                  10 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (4)          (3)          (1)          (4)          (2)          (4)          
      Thrombosis, Chronic                              1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (38)         (11)         (43)         (11)         (46)         (12)         
      Abscess                                          4 (11%)                  10 (23%)                   7 (15%)                  
      Cyst                                             6 (16%)                  11 (26%)                  10 (22%)                  
      Thrombosis                                       1 (3%)                    2 (5%)                                             
   Uterus                                             (44)         (11)         (46)         (12)         (49)         (12)         
      Angiectasis                                                                                          1 (2%)                   
      Hyperplasia, Focal, Histiocytic                                                                      1 (2%)                   
      Metaplasia, Squamous                                                       1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Endometrium, Cyst                                                                                                 1 (8%)      
      Endometrium, Hyperplasia, Cystic                34 (77%)      4 (36%)     30 (65%)      5 (42%)     35 (71%)      5 (42%)     
      Mucosa, Inflammation, Suppurative                3 (7%)                    7 (15%)                   4 (8%)       1 (8%)      
      Serosa, Inflammation, Suppurative                1 (2%)                    4 (9%)                    2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (41)         (11)         (44)         (12)         (45)         (11)         
      Hyperplasia                                      1 (2%)                    4 (9%)                    5 (11%)                  
      Myelofibrosis                                   28 (68%)                  23 (52%)      2 (17%)     27 (60%)      1 (9%)      
      Myeloid Cell, Hyperplasia                        1 (2%)                    6 (14%)                   3 (7%)       1 (9%)      
   Lymph Node                                         (46)         (11)         (47)         (12)         (49)         (12)         
      Iliac, Hyperplasia, Lymphoid                                                                         1 (2%)                   
      Iliac, Inflammation                              1 (2%)                                              1 (2%)                   
      Pancreatic, Hyperplasia, Lymphoid                1 (2%)                                              1 (2%)                   
      Pancreatic, Infiltration Cellular, Mixed Cell                                                        1 (2%)                   
      Pancreatic, Follicular, Necrosis                                                                     1 (2%)                   
      Renal, Hyperplasia, Lymphoid                                               2 (4%)                    2 (4%)                   
      Renal, Infiltration Cellular, Mixed Cell                                                             1 (2%)                   
      Renal, Inflammation                              1 (2%)                    1 (2%)                    1 (2%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05079-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTOL       CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Renal, Follicular, Necrosis                                                2 (4%)                    1 (2%)                   
   Lymph Node, Bronchial                              (38)         (9)          (37)         (6)          (43)         (11)         
      Hyperplasia, Histiocytic                                                  25 (68%)      2 (33%)     39 (91%)      8 (73%)     
      Hyperplasia, Lymphoid                                                     16 (43%)                  20 (47%)                  
      Infiltration Cellular, Mixed Cell                1 (3%)                                                                       
      Inflammation, Acute                              1 (3%)                    1 (3%)                    1 (2%)                   
   Lymph Node, Mandibular                             (35)         (7)          (38)         (11)         (36)         (11)         
      Cyst                                                                                                 1 (3%)                   
      Depletion Lymphoid                               1 (3%)                                                                       
      Hyperplasia, Histiocytic                         1 (3%)                                                           1 (9%)      
      Hyperplasia, Lymphoid                                                      1 (3%)                    3 (8%)       1 (9%)      
      Hyperplasia, Plasma Cell                         1 (3%)                                 1 (9%)                                
      Infiltration Cellular, Mixed Cell                                          1 (3%)                                             
      Inflammation                                                               1 (3%)                    1 (3%)                   
      Follicular, Necrosis                                                       1 (3%)                                             
   Lymph Node, Mediastinal                            (13)         (5)          (17)         (5)          (14)                      
      Hyperplasia, Histiocytic                         1 (8%)                    3 (18%)                   2 (14%)                  
      Hyperplasia, Lymphoid                                                      1 (6%)                    2 (14%)                  
      Infiltration Cellular, Mixed Cell                1 (8%)                                                                       
   Lymph Node, Mesenteric                             (35)         (11)         (32)         (11)         (37)         (10)         
      Depletion Lymphoid                                                         1 (3%)                    2 (5%)                   
      Hematocyst                                                                                           1 (3%)                   
      Hyperplasia, Histiocytic                                                   1 (3%)       1 (9%)       1 (3%)       1 (10%)     
      Hyperplasia, Lymphoid                                                      2 (6%)                    2 (5%)                   
      Hyperplasia, Plasma Cell                                                                             1 (3%)                   
      Infiltration Cellular, Mixed Cell                5 (14%)                   5 (16%)                   5 (14%)                  
      Inflammation                                                               2 (6%)                    1 (3%)                   
      Follicular, Necrosis                             3 (9%)                   12 (38%)                   7 (19%)                  
   Spleen                                             (45)         (11)         (45)         (12)         (50)         (12)         
      Congestion                                       2 (4%)                                                                       
      Hematopoietic Cell Proliferation                 8 (18%)                  12 (27%)                  10 (20%)      1 (8%)      
      Hyperplasia, Lymphoid                            5 (11%)                   8 (18%)                   6 (12%)                  
      Inflammation, Suppurative                        2 (4%)                                              1 (2%)                   
      Capsule, Inflammation, Suppurative               2 (4%)                    3 (7%)                    3 (6%)                   
      Lymphoid Follicle, Depletion Lymphoid            2 (4%)                    3 (7%)                    5 (10%)                  
      Lymphoid Follicle, Necrosis                      2 (4%)                    4 (9%)                    2 (4%)                   
   Thymus                                             (40)         (11)         (41)         (12)         (41)         (12)         
      Cyst                                             2 (5%)                    2 (5%)                                             
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                    1 (2%)                   
      Necrosis                                         3 (8%)                    5 (12%)                                            
      Cortex, Depletion Lymphoid                       8 (20%)      1 (9%)      12 (29%)                  15 (37%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05079-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTOL       CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (41)         (10)         (45)         (12)         (48)         (12)         
      Abscess                                                                                              1 (2%)                   
      Edema                                            1 (2%)                                                                       
   Skin                                               (46)         (11)         (47)         (12)         (50)         (12)         
      Alopecia                                         2 (4%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (46)         (11)         (49)         (12)         (50)         (12)         
      Periosteum, Femur, Proliferation Connective                                                                                   
          Tissue                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (46)         (11)         (49)         (12)         (50)         (12)         
      Hydrocephalus                                                              2 (4%)                                             
      Mineralization, Focal                           36 (78%)      5 (45%)     33 (67%)      6 (50%)     29 (58%)      4 (33%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (42)         (11)         (44)         (12)         (48)         (12)         
      Inflammation, Acute                              1 (2%)                                                                       
   Lung                                               (46)         (11)         (49)         (12)         (50)         (12)         
      Congestion                                       1 (2%)                    3 (6%)                                             
      Hyperplasia, Histiocytic                                                                             1 (2%)                   
      Hyperplasia, Macrophage                          2 (4%)                   45 (92%)      8 (67%)     43 (86%)     12 (100%)    
      Inflammation, Chronic Active                                              25 (51%)                  38 (76%)      1 (8%)      
      Metaplasia, Focal, Osseous                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal                                                              1 (2%)                   
      Perivascular, Inflammation, Suppurative                                    3 (6%)                    1 (2%)                   
      Pleura, Inflammation, Suppurative                1 (2%)                    2 (4%)                    5 (10%)                  
   Nose                                               (46)         (11)         (47)         (12)         (50)         (12)         
      Cytoplasmic Alteration                                                                                            2 (17%)     
      Cytoplasmic Alteration, Focal                   29 (63%)                  37 (79%)      5 (42%)     40 (80%)      8 (67%)     
      Developmental Malformation                       1 (2%)                                                                       
      Erosion, Focal                                   3 (7%)                                              1 (2%)                   
      Inflammation, Acute                              6 (13%)                   4 (9%)                    5 (10%)                  
      Ulcer, Focal                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05079-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTOL       CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)          (1)                                    
      Inflammation, Suppurative                                                  1 (100%)                                           
   Harderian Gland                                    (2)                       (2)                       (1)                       
      Inflammation, Suppurative                                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (46)         (11)         (47)         (12)         (50)         (12)         
      Casts Protein                                                              2 (4%)                                             
      Infarct                                          1 (2%)                    1 (2%)                                             
      Inflammation, Focal                              1 (2%)       3 (27%)      1 (2%)       1 (8%)       1 (2%)                   
      Metaplasia, Focal, Osseous                       1 (2%)                                              2 (4%)                   
      Nephropathy, Chronic                             1 (2%)                    1 (2%)                                             
      Capsule, Inflammation, Suppurative               3 (7%)                    6 (13%)                   5 (10%)                  
      Renal Tubule, Hyperplasia, Focal                                           1 (2%)                                             
   Urinary Bladder                                    (44)         (11)         (41)         (12)         (41)         (12)         
      Serosa, Inflammation, Suppurative                                          3 (7%)                    3 (7%)                   
      Submucosa, Hyperplasia, Lymphoid                 1 (2%)                                                                       
      Submucosa, Inflammation, Suppurative                                                                 1 (2%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05079-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          49           39           49           40           50           40           
  Scheduled Sacrifice                                              35                        33                        31           
  Early Deaths                                                                                                                      
    Natural Death                                     16            4           18            5           14            7           
    Moribund Sacrifice                                 1                         2            1            3            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                30                        28                        32                        
  Missing                                              1                                                                            
  Animals Examined Microscopically                    46           12           47           12           49           12           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (31)         (12)         (29)         (11)         (35)         (11)         
      Dilatation                                                                                           1 (3%)                   
      Epithelium, Hyperplasia, Papillary                                                                   1 (3%)                   
   Intestine Large, Cecum                             (34)         (12)         (35)         (12)         (37)         (12)         
      Hyperplasia, Lymphoid                                                      1 (3%)                    3 (8%)                   
   Intestine Large, Colon                             (36)         (12)         (38)         (12)         (39)         (12)         
      Hyperplasia, Lymphoid                            1 (3%)                                                                       
   Intestine Large, Rectum                            (32)         (10)         (32)         (12)         (31)         (10)         
      Serosa, Inflammation, Suppurative                                          1 (3%)                                             
   Intestine Small, Duodenum                          (32)         (12)         (30)         (12)         (34)         (12)         
      Hyperplasia, Lymphoid                                                                                1 (3%)                   
      Mucosa, Atrophy                                  3 (9%)                    7 (23%)                   3 (9%)                   
   Intestine Small, Ileum                             (33)         (12)         (32)         (11)         (35)         (12)         
      Hyperplasia, Lymphoid                            5 (15%)                   3 (9%)                    5 (14%)                  
      Mucosa, Atrophy                                  3 (9%)                    5 (16%)                   4 (11%)                  
      Peyer's Patch, Necrosis                          1 (3%)                                                                       
   Intestine Small, Jejunum                           (32)         (12)         (31)         (12)         (36)         (12)         
      Hyperplasia, Lymphoid                                                                                1 (3%)                   
      Mucosa, Atrophy                                  3 (9%)                    3 (10%)                   2 (6%)                   
   Liver                                              (45)         (12)         (47)         (12)         (48)         (12)         
      Abscess                                          1 (2%)                                              1 (2%)                   
      Focal Cellular Change                            4 (9%)                    3 (6%)                    5 (10%)      1 (8%)      
      Hematocyst                                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)                    2 (4%)                                             
      Infarct                                          2 (4%)                                                                       
      Inflammation, Focal                                                        3 (6%)                    1 (2%)                   
      Mineralization, Focal                                                      1 (2%)                                             
      Necrosis, Focal                                  4 (9%)                    5 (11%)                   4 (8%)                   
      Pigmentation, Focal, Hemosiderin                                                                     1 (2%)                   
      Bile Duct, Hyperplasia, Focal                                                                        1 (2%)                   
      Serosa, Inflammation, Suppurative                                                                    1 (2%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05079-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (42)         (12)         (39)         (12)         (42)         (12)         
      Serosa, Inflammation, Suppurative                                                                    1 (2%)                   
   Salivary Glands                                    (45)         (12)         (46)         (12)         (47)         (12)         
      Inflammation, Chronic                                         1 (8%)                                                          
   Stomach, Forestomach                               (43)         (12)         (41)         (12)         (46)         (12)         
      Hyperplasia, Focal, Squamous                                               1 (2%)                    1 (2%)                   
   Tooth                                                                        (3)                                                 
      Dysplasia                                                                  3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (45)         (12)         (46)         (12)         (49)         (12)         
      Thrombosis                                                                 1 (2%)                    1 (2%)                   
      Coronary Artery, Mineralization                                            1 (2%)                                             
      Myocardium, Degeneration, Focal                  1 (2%)                                                                       
      Myocardium, Fibrosis, Focal                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (43)         (12)         (46)         (10)         (47)         (12)         
      Spindle Cell, Hyperplasia                       38 (88%)                  37 (80%)      2 (20%)     35 (74%)      2 (17%)     
   Adrenal Gland, Cortex                              (43)         (11)         (46)         (10)         (47)         (11)         
      Atrophy                                          1 (2%)                                                                       
      Hyperplasia, Focal                                                         1 (2%)       1 (10%)                               
      Vacuolization Cytoplasmic, Focal                                           3 (7%)                    4 (9%)                   
   Parathyroid Gland                                  (25)         (6)          (21)         (6)          (26)         (4)          
      Cyst                                             3 (12%)                   1 (5%)                                             
   Pituitary Gland                                    (44)         (11)         (44)         (9)          (46)         (11)         
      Cyst                                             1 (2%)                                              1 (2%)                   
      Pigmentation, Lipofuscin                         1 (2%)                                                                       
   Thyroid Gland                                      (45)         (11)         (46)         (12)         (45)         (11)         
      Cyst                                             2 (4%)                    1 (2%)                    1 (2%)                   
      Follicular Cell, Hyperplasia                     4 (9%)                    8 (17%)                   8 (18%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05079-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (39)         (12)         (39)         (12)         (42)         (12)         
      Inflammation, Suppurative                        1 (3%)                    1 (3%)                                             
   Preputial Gland                                    (8)                       (6)                       (8)                       
      Dilatation                                       7 (88%)                   6 (100%)                  8 (100%)                 
      Inflammation                                     3 (38%)                                             1 (13%)                  
   Prostate                                           (40)         (12)         (43)         (12)         (44)         (12)         
      Inflammation, Suppurative                        3 (8%)                    7 (16%)                   4 (9%)                   
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Seminal Vesicle                                    (41)         (8)          (43)         (8)          (39)         (8)          
      Inflammation, Suppurative                                                  2 (5%)                    1 (3%)                   
   Testes                                             (43)         (12)         (44)         (12)         (45)         (12)         
      Aspermatogenesis, Diffuse                                                                            1 (2%)                   
      Atrophy, Diffuse                                                                                     1 (2%)                   
      Hypospermia                                      1 (2%)                    2 (5%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Seminiferous Tubule, Degeneration, Focal         3 (7%)                    4 (9%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (40)         (12)         (42)         (12)         (43)         (12)         
      Hyperplasia                                      4 (10%)                   1 (2%)                    1 (2%)                   
      Myelofibrosis                                    2 (5%)                    2 (5%)       1 (8%)                                
      Myeloid Cell, Hyperplasia                        4 (10%)                   7 (17%)                   1 (2%)                   
   Lymph Node                                         (45)         (12)         (46)         (12)         (48)         (12)         
      Iliac, Hyperplasia, Lymphoid                     1 (2%)                                                                       
      Iliac, Hyperplasia, Plasma Cell                  1 (2%)                                                                       
      Lumbar, Hyperplasia, Lymphoid                    1 (2%)                    1 (2%)                                             
      Lumbar, Hyperplasia, Plasma Cell                                           1 (2%)                                             
      Pancreatic, Inflammation, Granulomatous                                    1 (2%)                                             
      Renal, Depletion Lymphoid                                                                            1 (2%)                   
      Renal, Hyperplasia, Lymphoid                                                                         1 (2%)                   
   Lymph Node, Bronchial                              (32)         (9)          (39)         (9)          (44)         (10)         
      Abscess                                                                                              1 (2%)                   
      Hyperplasia, Histiocytic                         1 (3%)                   32 (82%)      4 (44%)     42 (95%)      7 (70%)     
      Hyperplasia, Histiocytic, Lymphoid                                         1 (3%)                                             
      Hyperplasia, Lymphoid                            3 (9%)                   10 (26%)                  23 (52%)                  
      Infiltration Cellular, Mixed Cell                3 (9%)                    1 (3%)                    3 (7%)                   
      Inflammation, Acute                              1 (3%)                                                                       
      Follicular, Necrosis                             1 (3%)                                                                       
   Lymph Node, Mandibular                             (23)         (6)          (23)         (9)          (19)         (4)          
      Hyperplasia, Histiocytic                                                   1 (4%)       1 (11%)                               
      Hyperplasia, Lymphoid                                         1 (17%)                   1 (11%)      1 (5%)                   
      Follicular, Necrosis                                                                                 1 (5%)                   
   Lymph Node, Mediastinal                            (9)          (5)          (10)         (4)          (7)          (3)          
      Hyperplasia, Histiocytic                         1 (11%)                   1 (10%)                   2 (29%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05079-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                                                      2 (20%)                                            
   Lymph Node, Mesenteric                             (36)         (10)         (39)         (9)          (40)         (10)         
      Depletion Lymphoid                               1 (3%)                                              2 (5%)                   
      Hyperplasia, Histiocytic                                                                2 (22%)                               
      Hyperplasia, Lymphoid                            4 (11%)      1 (10%)      3 (8%)                    6 (15%)      1 (10%)     
      Infiltration Cellular, Mixed Cell               18 (50%)                  20 (51%)                  13 (33%)                  
      Inflammation, Granulomatous                                                1 (3%)                                             
      Thrombosis                                                                                           1 (3%)                   
      Follicular, Necrosis                                                       6 (15%)                   2 (5%)                   
   Spleen                                             (44)         (12)         (44)         (12)         (47)         (11)         
      Hematocyst                                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                 6 (14%)                   7 (16%)                  10 (21%)                  
      Hyperplasia, Lymphoid                            3 (7%)                    2 (5%)       1 (8%)       3 (6%)                   
      Hyperplasia, Mast Cell                                                                               1 (2%)                   
      Inflammation, Granulomatous                                                1 (2%)                                             
      Lymphoid Follicle, Depletion Lymphoid                                      2 (5%)                    5 (11%)                  
      Lymphoid Follicle, Necrosis                      2 (5%)                    5 (11%)                   1 (2%)                   
   Thymus                                             (34)         (11)         (33)         (11)         (40)         (12)         
      Cyst                                             3 (9%)                    2 (6%)                    1 (3%)                   
      Hyperplasia, Lymphoid                                                                                1 (3%)                   
      Inflammation, Granulomatous                                                1 (3%)                                             
      Necrosis                                         1 (3%)                                              2 (5%)                   
      Cortex, Depletion Lymphoid                       6 (18%)                  10 (30%)                   8 (20%)                  
      Epithelial Cell, Hyperplasia, Focal              1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (44)         (12)         (45)         (12)         (48)         (12)         
      Abscess                                                                    1 (2%)                                             
      Alopecia                                         1 (2%)                                              1 (2%)                   
      Inflammation, Acute                                                        2 (4%)                                             
      Ulcer, Focal                                                               2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (46)         (12)         (47)         (12)         (49)         (12)         
      Rib, Cartilage, Fracture Healed                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (46)         (12)         (47)         (12)         (48)         (12)         
      Mineralization, Focal                           37 (80%)      5 (42%)     39 (83%)      2 (17%)     38 (79%)      5 (42%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05079-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (42)         (12)         (41)         (12)         (46)         (12)         
      Inflammation, Acute                              1 (2%)                                              1 (2%)                   
   Lung                                               (45)         (12)         (47)         (12)         (48)         (12)         
      Congestion                                       3 (7%)                    1 (2%)                    1 (2%)                   
      Hyperplasia, Macrophage                          3 (7%)                   46 (98%)     11 (92%)     48 (100%)    12 (100%)    
      Inflammation, Chronic Active                                              16 (34%)                  40 (83%)      5 (42%)     
      Thrombosis                                                                                           1 (2%)                   
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)                                                                       
      Alveolus, Mineralization, Focal                                                         1 (8%)                                
      Peribronchiolar, Inflammation, Chronic Active                              1 (2%)                                             
      Perivascular, Inflammation, Suppurative          1 (2%)                                                                       
   Nose                                               (45)         (12)         (46)         (12)         (47)         (12)         
      Cytoplasmic Alteration                                                                                            1 (8%)      
      Cytoplasmic Alteration, Focal                    5 (11%)                  23 (50%)      2 (17%)     40 (85%)      6 (50%)     
      Erosion, Focal                                   1 (2%)                    1 (2%)                    2 (4%)                   
      Inflammation, Acute                              4 (9%)                    4 (9%)                    7 (15%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Inflammation, Granulomatous                      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (45)         (12)         (46)         (12)         (48)         (12)         
      Casts Protein                                    1 (2%)                                                                       
      Cyst                                             2 (4%)                                                                       
      Hydronephrosis                                   3 (7%)                    1 (2%)                                             
      Inflammation, Chronic Active, Focal                           1 (8%)                    1 (8%)                                
      Inflammation, Focal, Suppurative                 3 (7%)                    5 (11%)                   3 (6%)                   
      Metaplasia, Focal, Osseous                                                 3 (7%)                                             
      Nephropathy, Chronic                             3 (7%)                                              2 (4%)                   
      Capsule, Inflammation, Suppurative                                                                   1 (2%)                   
      Cortex, Cyst                                                  1 (8%)                                                          
      Pelvis, Inflammation, Suppurative                2 (4%)                    5 (11%)                   1 (2%)                   
   Urinary Bladder                                    (43)         (12)         (38)         (12)         (43)         (12)         
      Dysplasia, Focal                                 1 (2%)                                                                       
      Inflammation, Chronic Active                     6 (14%)                   5 (13%)                   2 (5%)                   
      Ulcer, Focal                                                                                         1 (2%)                   
      Lumen, Calculus Micro Observation Only                                                                            1 (8%)
      Transitional Epithelium, Hyperplasia                                       1 (3%)      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                   
                             ----------              END OF REPORT             ----------                  
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